KR20010091059A - Insulin pump with blood glucose tester - Google Patents

Abstract

PURPOSE: An automatic injector for measuring blood sugar is provided in order that a doctor can measure blood sugar while watching the displaying condition with an extra measurement by displaying the blood sugar level and the injected quantity of an insulin injector in a display portion. CONSTITUTION: The automatic injector for measuring blood sugar includes a pipe(1), a connecting tool(2), a cover(110), a housing(120), a piston(122), a piston pushing instrument(150), an electric power supplying instrument(130), a rotary axis(131), a control button portion(123), a display portion(124), a battery cover(125), a reset button(121) and a bottom cover(140). The injector using the pipe(1) and the connecting tool(2) is connected through the cover(110). The cover(110) is connected to the upper part of the housing(120). The electric power is supplied to the housing(120) through the piston(122), the piston pushing instrument(150) and the electric power supplying instrument(130). The control button portion(123) conveys the order to the control portion and the display portion(124) displays the control condition. The battery cover(125) fixes the battery for supplying the power and the reset button(121) carries out the function of reset.

Description

Insulin pump with blood glucose tester

The present invention relates to a self-injector for automatically injecting insulin and the automatic injection device to simultaneously display the injection amount and blood glucose measurement results, in particular, the blood glucose meter is integrally formed in the housing of the autoinjector for automatically injecting insulin for a long time. And it comprises a control unit for controlling to display the blood glucose measurement result and the insulin injection amount at the same time, and the measurement result of the blood glucose measurement unit relates to an insulin auto-injector capable of blood glucose measurement configured to provide the control to determine.

Diabetes, a representative civilization disease of the 20th century, suffers from more than 100 million of the world's population of about 6 billion people. In Korea, about 2 million people are estimated to be diabetic, and about 10% of medical patients are diabetic. Until now, diabetes is recognized as a controlled disease, not a cure. Failure to control will result in loss of life due to various complications. The domestic mortality rate from diabetes has risen to 11.5 per 100,000 population (1990 statistics), bringing fears.

Diabetes mellitus is a disease in which blood glucose levels exceed 140 mg / dl on an empty stomach or 200 mg / dl after 2 hours of meal time. The exact cause of this high blood sugar level is not yet known. Insulin abnormalities are caused by the lack of insulin by the pancreatic beta cells that produce insulin, which is insufficient for insulin, or by the pancreatic beta cells, which secrete insulin normally. So-called insulin resistance does not raise blood sugar. Diabetes, which is absolutely lacking in insulin, is called insulin-dependent diabetes, and diabetes, which is secreted but insufficient in action, is called insulin-independent diabetes. It is not easy to distinguish diabetics from these insulin-dependent or non-dependent forms. Current methods of treating diabetes are divided into diet, exercise, drug therapy, and insulin injection. Pancreas transplantation is also being attempted.

Insulin injection is the treatment used in insulin-dependent diabetics, but it can also be effective in insulin-independent patients. Insulin injection is a common method of receiving insulin injections 1-2 times a day, but the amount of insulin secreted in the human body is not constant, so a large amount is secreted three times before and after meals and less at other times. Injecting an average of 2 to 2 injections with low insulin after meals, high blood sugar on the contrary, the amount of insulin at night is low blood sugar is high. That is, there is a disadvantage that the body is abnormal because the insulin supply is abnormal. Therefore, the reason why the conventional insulin injection method did not help prevent the complications of diabetes is because it did not provide a change in insulin secretion of normal people. Therefore, a more improved treatment method is a so-called insulin pump (mechanical artificial pancreas) and pancreatic beta-cell transplantation method that control the amount of insulin injected by computer to make it close to normal insulin secretion in the human body. Pancreatic beta cell transplantation involves diabetic patients transplanting normal beta cells of the pancreas to secrete the appropriate insulin to control blood sugar. Research was conducted in the United States in 1974 to overcome the problems of immunological rejection and pancreas transplantation. It was put to practical use by Professor Temberane of Yale University.

In general, a long-term injection auto-injector (called an insulin pump, insulin syringe, insulin auto-injector, etc.) has a structure in which a push means for pushing a syringe piston into a housing for receiving an injection syringe is coupled. This can exemplify JP-A-52-3292 and US Pat. No. 4,417,889. Since the Japanese Laid-Open Fire No. 52-3293 has a structure in which a syringe injector is installed outside the basic case, it requires a double case, which is inconvenient to carry. In this regard, a syringe having a dual case type was developed. The output of the oscillator A1 is provided to the timer A2, and the timer A2 output and the switch A4 output are the digital comparators, as shown in FIG. Is applied to (A3). The output of the digital comparator A3 is connected to the counter A6 and the flip-flop A9. The output of the other oscillator A5 is provided to the counter A6, the AND gate A10 (A11) and the counter A13. The digital comparator A7 output resets flip-flop A9, and the digital comparator A14 output resets flip-flop A16. The control unit A17 is connected to operate the counter A13 by the operation of a manual infusion switch A12. The output of the control unit A17 is provided to the counters A13, A16 and A21. The digital comparator A22 output is connected to the step motor driver A19 to stop the step motor A20. The output of the flip-flop A16 is connected to one input terminal of the OR gate A18 and the other input terminal of the AND gate A11 to which the output is connected. The step motor driver A19 is used to drive the step motor A20. Each fixed number of switches A4, A8, A15 and A25 have five protruding insert bars and provide reference values for the corresponding respective digital comparators A3, A7, A14 and A22. It performs the function. The light source A24 and the photo sensor A23 are configured to provide the sensing result to the counter A21, which is provided with the light source A24 and the photo sensor A23. In Fig. 3, several holes A26 are formed at regular intervals in the gear plate. The gear shaft A27 is fitted and fixed to the gear plate. The piston plate A28 is screwed with the gear shaft A27 so as to be movable. The light source A24 and the photo sensor A23 are installed on separate fixing plates at intervals from the gear plate at upper and lower vertical portions of the hole A26. An example of the structure including all of these configurations can be shown as shown in FIG. On the horizontal line between the gear mechanism (G) is installed, the gear mechanism (G) is driven by the motor (M). The driving of the motor M is controlled by the driving of the counter A21, the digital comparator A22, the switch A25 and the motor driver A19. The piston shaft A27 of the gear mechanism G is screwed to the piston plate A28 in the form of a nut, and the injection liquid (insulin) of the syringe I is moved to the needle N by the action of the piston plate A28. It is made to be injected. However, such a structure is easily infiltrated with water or moisture because the syringe is in conduction with the outside air. Accordingly, in order to take a shower during injection, it is inconvenient to take a shower after storing the housing in a separate sealing case.

For this purpose a sealable syringe has been proposed by the applicant, Figure 4 is a front view of the autoinjector illustrating this example, the top of the housing 20 with the lid 10, the bottom is sealed with the bottom cover 40 The coupling 10 is screwed to the cover 10, the connector (2) integral with the conduit (1). The connector 2 engages with the syringe syringe 21, which is coupled to the piston 22 inside the housing 20 to receive the injection liquid. On the bottom surface of the housing 20, a power supply means 30 is accommodated, and a disk-shaped push means 50 that rotates and drives the piston 22 upwardly by rotating on the rotation shaft 31 of the power supply means 30 is screwed. To be combined.

FIG. 5 is a plan view of FIG. 4, in which a cover 10 is installed on the left side of the surface of the housing 20, and a battery cover 24 is installed on the right side. The cover 10 is connected to a connector 2 connected to the conduit 1.

6 is a cross-sectional exploded view taken along line AA of FIG. 5, in the center of the cover 10, a connector 2 and a screw groove 11 for screwing are connected, and a bolt screw part for sealing and coupling the syringe holder 23 to the outer circumference thereof. 12) and packing (13) are installed. A push means guide protrusion 51 of the push means 50 is fitted below the syringe holder 23 to form a push means guide groove 25 for guiding the rising and falling of the push means 50, and FIG. 4. A piston guide groove 27 for guiding the rise of the piston 22 shown in the drawing is formed.

FIG. 7 shows the power supply means 30 fitted in the syringe holder 23 shown in FIG. 6 and the push means 50 on a disc screwed to the rotary shaft 31 thereof. Push means 50 is fitted to the push means guide groove 25 shown in Figure 6 on the outer periphery, the lower disk 54 with the push means guide protrusion 51 to move vertically, and the piston 22 There is a concave-convex means 52 which supports and rests the piston 22 and consists of an upper disc 55 which is integral with the lower disc 54. The power supply means 30 includes a deceleration mechanism 33 that decelerates the rotational force of the motor and provides it to the rotation shaft 31. A jig fitting groove (not shown) is formed in the upper disk 55 or the lower disk 54, and the push means guide protrusion 51 enters the center when the jig is fitted in the jig fitting groove.

When using this, in the state of FIG. 7 (assuming that the housing 20 is omitted), the piston 22 is inserted into the syringe 21 shown in FIG. 8, and a separate disposable needle (shown in the syringe 21) is shown. Insert a syringe (eg, insulin) in the vial and pull the piston 22 to store the syringe 21 in the syringe 21.

In this state, the piston 22 is placed in the push means 50 (of course, into the syringe holder 23 of FIGS. 6 and 4, and the piston guide groove 27 shown in FIG. 6 guides the piston shown in FIG. 8). The protrusions 26 are coupled to guide, and the push means guide protrusions 51 shown in FIG. 8 are coupled to guide along the push means guide grooves 25), and the lid 10 with the upper end of the syringe holder 23. Screw in. In this state, when the connector 2 is screwed with the cover, the connector 2 is naturally engaged with the syringe tip 21-1. Thus, the contents of the syringe 21 in the sealed state are automatically scanned in accordance with the operation of the push means 50. At this time, the push means 50, the push means guide protrusion 51 is coupled to the push means guide groove 25 of the syringe holder 23 so that it can be raised to the right position, the piston guide protrusion 26 shown in FIG. Along the piston guide groove 27 shown in Figure 6 allows the piston 22 to rise to the right position.

On the other hand, an example of a portable automatic needle unit for long-term injection is, as shown in Fig. 9, a horizontal needle member (aka, straight butterfly needle) 3 having a “-” shape, a conveying pipe (conduit) 1, and a housing. It consists of the connector 2 connected with the connector part 20-5 of (20).

However, since the needle of the above-described method is composed of a straight butterfly needle member (3) is very painful to be inserted when the user inserts directly into his skin tissue. In other words, insulin, which is mainly used as a syringe injection for a long time, is injected by a diabetic patient by injecting a needle directly into the body, but a straight butterfly needle needs to be inserted into the body (skin tissue) at an angle so that it is directly inserted when inserting it. Check with your eyes. In this case, the user who injects the needle into his body is very painful. In addition, since the straight butterfly needle member 3 is inserted into the skin tissue at an angle, the flow becomes easy, so that the skin tissue is damaged and the pain is severely generated as the blood flows out.

Since the needle unit having the straight butterfly needle member 3 is inserted into the skin tissue at an angle as mentioned above, the needle is easily blocked by the cell tissue, and the injection of insulin is not smoothed. The diameter is bound to be thick. In this case, excessive insulin injection may occur, and expensive insulin waste may be caused. For example, the air in the delivery tube 1 and the needle member 3 must be completely removed before inserting the needle to supply insulin. To this end, the insulin is sent out by pumping of the automatic insulin injector to remove the air by discharging it out of the housing 20 through the transfer pipe 1 and the needle member 3, wherein the diameter of the transfer pipe 1 is large Positive insulin is thrown away.

To this end, a needle unit has been developed that can be bent directly into the skin to be used in a-shape, as shown in FIGS. 10 and 11, consisting of a needle member 3, a transfer pipe 1, and a connector 2.

The needle member 3 forms the shape of the needle 3-11 in the shape of “a”, and the needle 3-11 is inserted into the connection rib 3-12 and is connected to the connection rib 3. -12) to form the transfer pipe (1) integrally connected. The needle 3-11 inserted into the connecting rib 3-12 is formed such that the bent portion 3-13 is formed as shown in FIG. 11, and can be pushed when the needle 3-11 is inserted. The pressing piece 3-14 is integrally formed. The bacterial infection prevention member 3-14-1 made of the nonwoven fabric which has been sterilized in the forward direction is adhered to the pressing piece 3-14. The material of the bacterial infection prevention member 3-14-1 is used as natural wood pulp. The diameter of the feed pipe 1 is made thin, and the length is formed longer. The connector 2 is formed to connect to the lower end of the transfer pipe 1, forming a male screw portion (2-15) in the connector (2) having a protective cap (2--16) having a female screw portion (2-16) 17). In addition, the connector 2 is coupled to the connector portion 20-5 of the housing 20 of the automatic insulin injector, which connector portion 20-5 is coupled to form a female screw portion 20-5a. In FIG. 10, reference numerals 3-18 denote needle protection caps.

To receive insulin through the housing 20 of the automatic insulin injector using the syringe unit configured as described above, first, remove the protective cap (2-17) coupled to the connector (2) and the connector portion 20-5 ) And screw. Next, the needle protective cap 3-18 inserted in the needle 3-11 is removed. Then, the pressing piece (3-14) is inserted into the skin tissue of the user while pushing the fingertips. At this time, since the needle (11) is composed of a "b" type can be inserted into the skin tissue vertically so that the user can be instantaneously inserted without the need to visually confirm that the needle is inserted. Accordingly, the user can safely eliminate the pain that follows when the needle is inserted into his or her body, and can be conveniently used as shown in FIG. 13. There is no fear that the inlet of the needle 3-11 by the layered skin tissue will be blocked because it is inserted. Therefore, the supply of insulin can be facilitated. As the insulin can be smoothly supplied as described above, the diameter of the delivery pipe 1 can be reduced, and the length thereof can be increased. Since the diameter of the delivery pipe 1 can be reduced, the waste of insulin can be minimized and the cost can be reduced when the air in the delivery pipe 1 and the needle 3-11 is removed. As it can be lengthened, the width of the portion that can be inserted when used as shown in Figs. 12 and 13 can be widened for ease of use. As the natural nonwoven fabric sterilized in front of the pressing piece (3-14) is fixed, the pressing piece (3-14) made of synthetic resin is directly applied to the skin when the needle (3-11) is inserted into the skin tissue to supply insulin. We can prevent contact and can prevent bacterial infection. As the shape of the needle 3-11 is “a”, it is vertically inserted when used by injecting into the skin tissue. Thus, even when an external force is applied, the flow of the needle 3-11 does not easily occur, thereby causing tissue damage. Prevents blood flow and does not cause pain.

However, this type of syringe unit is used by installing a syringe protective cap (3-18) as shown in Figure 14, the syringe protective cap (3-18) is a diameter of the same diameter as the needle (3-11) (3-18) -1) and an insertion diameter 3-18-2 which is an inner diameter of a diameter larger than the diameter of the needle 3-11. Therefore, when inserting the syringe protective cap (3-18) to the needle (3-11), there is a problem that the needle (3-11) is fitted to the inner wall of the insertion diameter (3-18-1), etc. ), The diameter of the fitting diameter is small, and the injection liquid penetrates into the bacterial infection prevention member (3-14-1) due to capillary phenomenon when the injection liquid flows to remove the initial air, causing discomfort to the patient at the time of injection. . In addition, there is a sharp bent portion (3-11-1) between the vertical portion and the bent portion (3-13) of the needle (3-11), if the movement is severe during use as shown in Figure 15 (movement or work a lot, or use If the user intentionally moves the vertical tip position to the dashed state by necessity, excessive stress is applied to the bent portion 3-11-1, resulting in a problem in reliability of the product.

In order to solve this problem, a portable auto-injector was developed in which the rotating shaft was detached from the housing when the syringe was refilled with the syringe, and the position was easily set by looking at the position. 16 shows an example of such an automatic syringe, in which a syringe using a conduit 1 connected to a connector 2 is connected through a cover 110, and the cover 110 is sealed at the top of the housing 120. Combined as much as possible. The housing 120 corresponding to the cover 110 includes a syringe 21, a piston 122, a piston push means 150, and a rotation shaft 131 for providing power through the power providing means 130. The housing 120 includes a control button 123 for commanding a control board (not shown), a display unit 124 such as an LCD for displaying a control state, and a battery cover 125 for fixing a battery for supplying power. And a reset button 121 for performing a reset function. 140 is a bottom cover.

FIG. 17 is a plan view of FIG. 16. The upper surface of the housing 120 includes a battery cover 125, a reset button 121, a cover 110, and a connector 2 connected to the cover 110. 2) has a configuration in connection with the conduit (1).

FIG. 18 is a plan view showing a structure in which the piston 122 and the push means 150 are placed and the power transmission means with the cover 110 of FIG. 17 omitted, and FIG. 19 is a sectional view taken along line VII-VII of FIG. In the lower center of the syringe holder 126 of the housing 120, a locking rotator 132 connected to the power supply unit 130, and a push means guide groove 25 for guiding the push means 150 to rise. And a piston guide groove 27 for guiding the linear vertical movement of the piston 122. The power providing means 130 and the locking rotator 132 are installed in the power providing means housing 130-1, and the power providing means housing 130-1 is coupled to the lower end of the housing 120.

FIG. 20 is an enlarged partial perspective view illustrating a coupling structure between the locking rotary hole 132 formed in the syringe holder 126 of the housing 120 and the rotating shaft 131 that is powered through the housing 120. A power supply means housing 130-1 is detachably coupled; A cross groove formed to be detachably coupled to the gear 132-3 coupled to the output end of the power providing means 130 and the coupling pin 133 of the rotary shaft 131 which is integrally formed with the gear 132-3. A locking rotor 132 having a 132-1; A rotating shaft (131) having a coupling pin (133) coupled to and separated from the cross groove (132-1) at a lower portion to linearly move the push plate (154) of the push means (150); A piston edge protrusion 122-2 which is screwed with the rotary shaft 131 and guides the push plate 154 along the push means guide groove 25 so as to be movable; and a piston edge integral with the piston 122 ( A piston edge having a push plate engaging projection 151-1 engaging with the push plate engaging groove 122-3 of 122-1 and a piston edge protrusion 122-2 guided along the piston guide groove 27. A piston 122 having a 122-1; It consists of a syringe 21 for supplying the injection liquid received along the piston 122 to the conduit 1 shown in FIG. The locking rotary ball 132 and the coupling pin 133 forms a coupling means. The power providing means (130-1) forms a guide ring plate (130-2) on a ring with an open top, and the guide ring plate (130-2) is a cross-shaped groove (132-) forming a locking rotary hole (132). Rotating shaft coupler 132-4 forming 1) is coupled.

FIG. 21 is an exploded perspective view illustrating the separated rotating shaft 131, the push means 150 coupled thereto, the piston 122, and the syringe 21, and FIG. 22 is a cross-sectional view illustrating a coupled state. 131 is made of a screw rod, the lower end of the rotary shaft 131 is formed integrally with the coupling pin 133 is coupled to the cross-shaped groove (132-1), the upper end of the cap screw for screwing the rotary shaft 131 (cap type) The head 131-1 is coupled. Push means 150 is screwed to the rotating shaft 131 to be movable. Push means 150 is a push plate 154 for screwing in the form of a nut and the rotating shaft 131, and a horizontal protrusion on the push plate 154 to engage with the push means guide groove 25 shown in FIG. Push plate guide protrusion 151, push plate coupling protrusion (151-1) coupled with the push plate coupling groove (122-3), the insertion protrusion (155) for fitting the piston 122, the insertion projection ( And a snap ring groove 156 on the ring formed in 155. A piston ring 122-4 is formed in the piston 122 corresponding to the snap ring groove 156. The piston 122 is coupled to the piston 122 for discharging the contents of the syringe 21 by a piston action, the piston edge 122-1 is formed at the lower end of the piston 122, the piston edge 122- Piston edge protrusion 122-2 is protruded in 1). The piston edge 122-1 also forms a push plate engaging groove 122-3 engaged with the push plate engaging protrusion 151-1.

23 is a cross-sectional view showing an example of the installation state of the reset button 121, the reset button 121 is coupled to the housing 120, at least one of the reset button 121 and the housing 120 for sealing The packing 121-1 is installed.

24 is a block diagram showing an example of the control circuit of the syringe, the control button unit 123 for controlling the control, the control unit 170 of the microcomputer function for recognizing the operation of the control button unit 123, and the recognized A display unit 124 for outputting and displaying data, a ROM 165 for storing various data and programs, a motor driver 167 for driving the motor 168 by the control output of the controller 170, A motor 168 whose rotational force is controlled by the motor driver 167 and a photo coupler 169 sensing the rotational force of the motor 168 may be illustrated. As a preferable example of the control unit 170, the first and second control units 171 and 172 having the same function may be configured so that the function can be continued even if at least one occurs. Terminals P1-P5 and P1 ′ -P2 ′ shown in the controllers 171 and 172 are ports connected to data and / or bus lines. The motor 68 may exemplify a stepping motor, a servo motor, or the like.

The syringe constructed as described above is first screwed into the insertion protrusion 155 and the push plate 154, the upper portion of the rotating shaft 131 is screwed inside, and then the lower portion is fitted with a coupling pin 133. And the upper end of the rotating shaft 131 is screwed to the head (131-1). Subsequently, the rotation shaft 131 and the insertion protrusion 155 of the push means 150 are integrally coupled to the push plate coupling groove 122-3 of the piston 122, and the push plate coupling protrusion 151-1 is provided. Fit to be coupled to the push plate coupling groove (122-3). In this case, the push plate coupling groove 122-3 is formed in a plurality of small pitch intervals in the form of a gear, and the coupling protrusions 151-1 for coupling thereto are easily assembled when formed intermittently. In order to obtain such convenience, if the push plate guide protrusion 151 is removed, the reference position is lost, so assembly is easy. Of course, if there is a guide protrusion (122-2) has the advantage of operating in the correct position. Then, the needle is inserted into a separate injection vial, and the syringe 122 is filled with the syringe 21 using the piston 122 and the rotating shaft 131 together. If the piston 122 in the pre-fill state is a dashed-dotted state in FIG. 22, the filled state may be represented by the solid line state in FIG. 22. In this case, check the sign (not shown) marked on the housing 120 so that the length of the rotating shaft 131 forms a set length (the length that can be coupled to the cross groove 132-1 of the locking rotator 132). Or, if you use a separate length check jig can conveniently adjust the exact capacity and the initial rotation axis 131 position. In such a state, when the coupling pin 133 enlarged as shown in FIG. 20 is lowered as shown by an arrow to be coupled to the cross groove 132-1 of the locking rotator 132, rotational force through the power providing means 130 is obtained. The rotating shaft 131 integrated with the coupling pin 133 rotates when the locking rotary ball 132 rotated by the gear 132-3 rotates. In this case, the rotational force is also transmitted to the screw-coupled push plate 154, but the push plate 154 has a push plate guide protrusion 151 to be supported along the push means guide groove 27, so that the push plate 154 has the rotation shaft 131. ) Is provided with up and down movement force without rotation.

Meanwhile, the coupling pin 133 is coupled to the cross groove 132-1 shown in FIG. 20 in a state where the length of the push means 150 and the rotation shaft 131 are screwed to form an initial position in advance. In this state, when the rotary shaft 131 rotates in the counterclockwise direction in FIG. 12, the rotary shaft 131 rotates and thus the push plate 154 supported by the push means guide groove 25 is raised, and the push plate ( The piston 122 coupled to the 154 is to inject the injection liquid held in the syringe 21 into the needle unit through the connector 2 for a long time. This supplies the injection liquid through the conduit 1 shown in FIG. 16, which provides the injection liquid to the human body through the needle (called the human body) of the needle unit. When the injection solution is provided for a long time, the piston 122 rises to the initial two-dot chain position, and the user detaches the needle unit from the body and stops using the syringe. That is, after use, the needle connected to the conduit is detached from the body, the connector 2 is also separated from the cover 110, the screwed cover 110 is loosened, and then the syringe 21 and the procedure of FIG. In the reverse order, the coupling pin 133 is separated from the cross groove 132-1, and then the syringe 21, the piston 122, the push means 150, and the rotating shaft 131 are integrally separated from the syringe holder 126. Let's do it. In the case of reuse, the injection liquid is injected by the action of a piston, and then rotated by hand to return the rotary shaft 131 to the original position as described above, so that the rotary shaft 131 enters the piston 122 as shown in FIG. 22 (solid state). . The adjustment may be indicated by a predetermined reference position anywhere on the housing 120, or may be provided with a separate reference position for displaying the reference position. In this case, the head 131-1 is screwed to the top of the rotating shaft 131 in the form of a cap, and once the push plate 154 and the rotating shaft 131 are screwed together, the rotating shaft 131 is formed by the head 131-1. Function to be separated from the push plate 154 to improve the durability of the product. Coupling pin 133 is adjusted to a predetermined position (length) in the above coupling so that the coupling pin 133 is inserted into the cross-shaped groove (132-1) of the locking rotator 132. In order to facilitate the coupling, the coupling position of the rotation shaft 131 and the push means 150 is adjusted in advance. The use of the separate rotating shaft 131 is a push means 150 is raised in accordance with the rotation of the rotating shaft 131 once the injection liquid is supplied due to the characteristics of the auto-injector, but should be returned to the initial position again when supplying the injection liquid. Due to the nature of supplying the injection solution for a long time, the rotational speed of the rotating shaft is extremely low, so that the rotational shaft 131 can be detachably detached in order to eliminate the return time, which is about 5-10 minutes. The rotary shaft 131 is rotated in only one direction to simplify the control function. In particular, the cover 110, the battery cover 125, the reset button 121 and the bottom cover 140 are all configured to seal, so that the injection liquid in the syringe 21 is supplied to the body, and thus the inside of the housing 120 If the reset button 121 coupled to the housing 120 is made of a known semi-permeable material having the characteristics of blocking water and releasing air, to prevent the overload of the piston 122 action due to the vacuum of the external air, The inflow is possible and the moisture infiltration is prevented to allow the ingress of moisture into the housing 120 and allow the inflow of external air to prevent the interior of the housing 120 from becoming a vacuum. This increases manufacturing costs when the entire housing 120 is made of a known semi-permeable material, but makes a part of the semi-permeable material to minimize the cost for this part, thereby maintaining the semi-permeable function and contributing to the advantage of installation and cost reduction. . In this case, the packing 121-1 is preferably provided at at least one of the reset button 121 and the housing 120 to maintain the sealing characteristics.

However, such an autoinjector performs an inherent function of performing an automatic syringe function, and a diabetic patient has a hassle to measure blood glucose levels separately, and a doctor records it over time through a separate blood glucose meter and based on this. It is inconvenient to adjust the degree of insulin injection amount, there is an error of time for each glucose measuring device used, it is difficult to accurately contrast the measurement of time.

The present invention aims to solve this problem, and an object of the present invention is to provide an autoinjector which displays the intrinsic function of an autoinjector which automatically injects insulin, and simultaneously shows an injection amount and a blood glucose measurement result.

To this end, the present invention includes a control unit for integrally forming a blood glucose meter in the housing of the autoinjector for automatically injecting insulin for a long time, and to display the blood glucose measurement result and the insulin injection amount at the same time, the measurement result of the blood glucose measurement unit Provided by the configuration.

1 is a control block diagram of a conventional portable automatic syringe,

2 is a perspective view illustrating an installation example of the photo sensor of FIG. 1;

3 is a cross-sectional view of a conventional syringe in a state in which the configuration of FIG. 1 is used in combination;

4 is a front view showing another example of a conventional portable auto-injector,

5 is a plan view of FIG. 4;

6 is an exploded view taken along the line A-A of FIG.

7 is a front view showing an example of a conventional power supply means;

8 is an exploded view of a use state showing an example of a conventional push means,

9 is a perspective view showing an example of a conventional needle unit,

10 is a perspective view showing another example of a conventional needle unit;

11 is a partial cross-sectional view showing an example of the needle unit of FIG. 10;

12 is a partially enlarged view showing a state of use of the needle unit of FIG. 10;

13 is a perspective view showing a state of use of the needle unit of FIG.

14 is an enlarged cross-sectional view of a main portion of the needle unit of FIG. 10;

15 is an explanatory diagram showing a disadvantage in use of FIG. 14;

16 is a schematic configuration diagram of another needle unit;

17 is a plan view showing a planar state of FIG.

18 is a plan view showing a state in which the cover is removed in the plane state of FIG.

FIG. 19 is a cross-sectional view showing a sectional view taken along line XVIII of FIG.

20 is an enlarged partially cutaway exploded perspective view of the main portion of FIG. 16;

21 is an exploded perspective view of the main portion of FIG. 16;

FIG. 22 is a cross-sectional view illustrating a coupling state of FIG. 16; FIG.

FIG. 23 is an enlarged cross-sectional view showing the configuration of the reset button shown in FIG.

24 is a block diagram showing an example of a control configuration of the insulin pump shown in FIG. 16;

25 is a perspective view of an insulin pump showing an example of the present invention,

26 is a cross-sectional view showing an example of a blood sugar measuring means of the present invention;

27 is a block diagram of the present invention;

28 is a configuration example showing an example of a control panel of the present invention;

29 is a graph showing an example in which blood glucose and insulin levels are displayed simultaneously by the present invention.

Explanation of symbols for the main parts of the drawings

1; conduit 2; connector 2-15; male threaded portion

2-16; Female thread 2-17; Protective cap 3; Needle member

3-11; needle 3-11-1; bend 3-12; connecting rib

3-13; Bend 3-14; Push piece 3-14-1; Bacterial infection prevention member

3-18; protective cap 3-18-1; fitting diameter 3-18-2; insertion diameter

10; cover 11; screw groove 12; bolt thread

13; packing 20; housing 20-5; connector

21; syringe 22; piston 23; syringe repairer

24; battery cover 25; push means guide groove 26; piston guide protrusion

27; piston guide groove 30; power supply means 31; rotating shaft

32; motor 33; deceleration mechanism 40; bottom cover

50; push means 51; push means guide protrusion 52; uneven means

54; lower disc 55; upper disc 110; cover

120; housing 121; reset button 122; piston

122-1; piston edge 122-2 piston edge protrusion 122-3; push plate coupling groove

123; control button unit 124; display unit 125; battery cover

126; syringe repair 130; power supply means 131; rotating shaft

131-1; head 132; locking rotator 132-1; cross recess

133; coupling pin 140; bottom cover 150; push means

151; push plate guide protrusion 151-1; push plate coupling protrusion 154; push plate

155; insertion protrusion 156; snap ring groove 163; display unit

165; Rom 167; Motor drive 168; Motor

169; photocoupler 170; controller 171; first controller

172; second control unit 200; blood glucose measurement unit 210; control panel

211; measuring lamp 221; measuring lamp hole 222; insertion hole

223; measuring housing 224; fixing protrusion 230; measuring probe

That is, the present invention provides a blood glucose measurement unit integrally formed on one side of the syringe housing, a control unit for simultaneously controlling the output of the blood glucose measurement unit and the autoinjector, and the state and measurement of the syringe in the autoinjector capable of long-term injection. The present invention is to provide an insulin injector capable of measuring blood glucose, including a display unit for simultaneously outputting blood sugar.

The blood glucose measurement unit has a control housing for converting the measurement value through the measurement lamp so that the control unit recognizes, a measurement housing having a measurement hole is placed so that the measurement lamp is exposed through the measurement lamp hole and fitting the measurement probe, and the fitting of the measurement probe It is preferable to include a fixing protrusion which is installed in the measuring housing to be fixed so as to fix the coupling state.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

25 is a perspective view of the present invention, the syringe using the conduit 1 connected to the connector 2 is connected through the cover 110, the cover 110 is coupled to seal the upper end of the housing 120, The housing 120 corresponding to the cover 110 includes a syringe 21, a piston 122, a piston push means 150, and a rotation shaft 131 for providing power through the power providing means 130. The housing 120 includes a control button 123 for transmitting a command to the control unit, a display unit 124 such as an LCD for displaying a control state, a battery cover 125 for fixing a battery for supplying power, and a reset. In the insulin syringe containing a reset button 121 and the bottom cover 140 to perform a function,

The blood glucose measurement unit 200 including the measurement housing 223 is installed on at least one side of the housing 120. The measurement housing 223 has an insertion hole 222 into which the measurement probe 230 described below is inserted.

FIG. 26 is an exploded cross-sectional view illustrating the blood glucose measurement unit 200 according to the present invention. The blood glucose measurement unit 200 controls the measurement lamp 211 and allows the controller 170 to recognize the measurement value through the measurement lamp 211. Measuring housing 223 having a control panel 210 for converting, the measuring lamp 211 is placed so as to be exposed through the measuring lamp hole 221 and the insertion hole 222 to fit the measuring probe 230, and the It is configured to include a fixing projection 224 that is installed in the measuring housing 223 in order to fix the fitting state of the measurement probe 230. The measuring probe 230 is formed in the position corresponding to the measuring lamp 211 when fitting the fitting hole 231 and the measuring probe 230 to the insertion hole 230, the fitting fitting to the fixing protrusion 224 It comprises a light transmission hole 233 and a measuring plate 235 covering the light transmission hole 233.

27 shows a control button 123 for instructing control, a control unit 170 of a microcomputer function for recognizing operation of the control button 123, a display unit 124 for outputting and displaying the recognized data; A ROM 165 storing various data and programs, a motor driver 167 driving the motor 168 by the control output of the controller 170, and a motor whose rotational force is controlled by the motor driver 167. 168 and a photo coupler 169 sensing the rotational force of the motor 168. The control unit 170 is also connected to the blood sugar measurement unit 200 to enable blood sugar measurement. As a preferable example of the control unit 170, the first and second control units 171 and 172 having the same function may be configured so that the function can be continued even if at least one occurs. The terminals P1-P6 and P1 ′ -P2 ′ shown in the controllers 171 and 172 are ports connected to data and / or bus lines. The motor 68 may exemplify a stepping motor, a servo motor, or the like.

28 is a block diagram showing an embodiment of the control panel 210 of the present invention, and shows a configuration of a control panel 210 having a function of receiving a command of the controller 170 and a measurement value of the measurement lamp 211. The control panel 210 emits a lamp 211 based on a digital-to-analog converter 212 for converting an output signal through one terminal P6 of the control unit 170 into an analog signal, and a conversion output of the digital-to-analog converter 212. Measurement comprising a lamp driver 213 for driving the lamp 211-1 and a light receiving lamp 211-2 for receiving light reflected through the measurement plate 235 for emitting light through the light emitting lamp 211-1. A lamp signal receiving unit 214 for receiving the light received through the lamp 211, the light lamp 211-2 of the measuring lamp 211, and a lamp signal receiving unit for amplifying the received signal of the lamp signal receiving unit 214 ( 214 and an analog-to-digital converter 215 that digitally converts the reception output of the ramp signal receiver 214 and provides it to the terminal P6 of the controller 170.

29 shows an example of a graph showing an example of the display unit shown by the present invention.

The present invention configured as described above is omitted mainly for the description of the infusion function of insulin, and will be described mainly on blood sugar measurement. In order to measure blood glucose, an autoinjector is used as shown in FIG. 25 and the injection amount used may indicate an output state as shown in FIG. 29. In addition, the blood glucose measurement can be easily measured using the blood sugar measurement unit 200 shown in FIG. The blood sugar measurement of the blood sugar measuring unit 200 functions as a connection configuration with the control unit 170 as shown in FIGS. 26 to 28. That is, in FIG. 28, when the setting signal for measurement is output through the terminal P6, the analog-to-digital converter 212 is converted into an analog signal, and the converted signal is driven to drive the lamp 211-1 for light emission. Amplified by the driving unit 213, the light emission of the lamp 211-1 is emitted from the measuring plate 235 is received by the lamp 211-2. The received signal is amplified by the ramp signal receiver 214 and then converted into a digital value by the analog-digital converter 215 and applied to the controller 170 through the terminal P6. The controller 170 recognizes this and outputs the recognized time and recognition value to the display unit 124, and outputs the blood glucose value at the corresponding time as a graph as shown in FIG. In this case, the blood glucose values are recorded for each corresponding time, and the recorded values are output such that the measured values recognized by the controller 170 are changed in the form of a graph in which the reference point changes for each measurement time. In this case, the graph shape can be varied or designed differently.

The present invention described above is not limited to the above-described embodiments and drawings, and various permutations, modifications, and changes can be made without departing from the technical spirit of the present invention. It will be apparent to those who have

As described above, the present invention measures the amount of insulin injected and the corresponding blood glucose level in the insulin autoinjector, and simultaneously displays the blood sugar level and the amount of the insulin injector displayed on the display. It can be measured conveniently while viewing the display status without having to measure it separately.

Claims (3)

In the auto-injector that can be injected for a long time, the blood sugar measurement unit 200 is formed integrally on one side of the syringe housing, the control unit 170 for controlling the output of the blood glucose measurement unit 200 and the auto-injector, and the syringe The insulin injection syringe capable of measuring blood glucose, characterized in that it comprises a display unit for outputting the state of the injection amount and the measured blood glucose at the same time. According to claim 1, wherein the blood sugar measuring unit 200 controls the measurement lamp 211 and converts the measurement value through the measurement lamp 211 so that the control unit 170 recognizes, and the measurement lamp 211 ) Is placed so as to be exposed through the measuring lamp hole 221 and the measuring housing 223 having an insertion hole 222 fitting the measuring probe 230, and fixing the fitting coupling state of the measuring probe 230 Insulin auto-injector capable of measuring blood glucose, characterized in that it comprises a fixed projection 224 installed in the measuring housing 223. According to claim 1, wherein the blood glucose measurement unit 200 is an insulin auto-injector capable of measuring blood glucose, characterized in that installed on the side of the insulin auto-injector housing (120).