KR100755528B1 - Insulin pump with intelligent sensor - Google Patents

Abstract

In the present invention, a syringe in the housing, coupled to the syringe for receiving the automatic injection piston, the piston is operated in the insulin auto-injector made through the power supply means driven by the control unit,

A pressure sensor for recognizing the downward pressure of the rotating shaft is placed in the lower part of the rotating shaft which is powered by the power supply means of the insulin auto-injector to make the piston move vertically.

The operation of the pressure sensor is recognized by the control unit that controls the automatic scanning, and when excessive pressure is generated, it alerts that the injection liquid is blocked.

The lower part of the rotating shaft 131 is coupled to the output side gear 132-3 constituting the power providing means 130, and the lower side of the rotating shaft 131 at the lower end of the output gear shaft 132-5 of the output side gear 132-3. It is an automatic syringe capable of detecting the clogging of the injection liquid, characterized in that the pressure sensor 200 for recognizing the pressure is installed.

Automatic syringe, clogging prevention, pressure sensor

Description

Injection syringe capable of detecting clogging of injection liquid {Insulin pump with intelligent sensor}

1 is a perspective view of an autoinjector,

2 is a plan view showing a planar state of FIG.

3 is a plan view showing a state in which the cover is removed in the planar state of FIG.

4 is a cross-sectional view showing a cross-sectional view taken along line VII-VII of FIG. 3;

5 is an enlarged exploded perspective view of the main portion of FIG. 1;

6 is an exploded perspective view of the main part of FIG. 1;

7 is a cross-sectional view illustrating a coupling state of FIG. 6;

8 is a sectional view of an output shaft portion through a general power supply means;

9 is a block diagram showing an example of a control configuration of an insulin pump;

10 is a graph showing the blood glucose level with respect to the amount of insulin of the insulin pump,

11 is a sectional view showing the main parts of the present invention;

12 is a block diagram of the present invention.

Explanation of symbols for the main parts of the drawings

21; syringe 120; housing 130; power supply means 130-1; power supply means housing 130-3; gear box lower plate 130-5; shaft hole 131; rotary shaft 132-3; gear 132-4; rotary shaft coupler 132-5; Gear shaft 140; bottom cover 150; push means 170, 171, 172; controller 200; pressure sensor 210; buzzer

Patent Registration No. 10-0353229

Japanese public utility fire fighting 52-3292

U.S. Patent 4,417,889

The present invention relates to an automatic syringe capable of detecting injection liquid clogging, and when the injection liquid is blocked, by placing a pressure sensor under the syringe piston drive rotary shaft under overload, it is determined that the pressure sensor senses when the pressure sensor is sensed and alerts the user. The present invention relates to an auto-injector capable of detecting clogging of injection liquid, which improves stability by giving.

Diabetes, a representative civilization disease of the 20th century, suffers from over 100 million of the world's population of about 6 billion people. In Korea, about 2 million people are estimated to be diabetic, and about 10% of medical patients are diabetic. Until now, diabetes is recognized as a controlled disease, not a cure. Failure to control will result in loss of life due to various complications. The domestic mortality rate from diabetes has risen to 11.5 per 100,000 population (1990 statistics), bringing fears.

Diabetes mellitus is a disease in which blood glucose levels exceed 140 mg / dl on an empty stomach or 200 mg / dl after 2 hours of meal time. The exact cause of the rise in blood sugar levels is not yet known. The reason that has been identified so far is that there is an abnormality in insulin assimilating sugar. Insulin abnormalities are caused by the lack of insulin by the pancreatic beta cells that produce insulin, which is insufficient for insulin, or by the pancreatic beta cells, which secrete insulin normally. So-called insulin resistance does not raise blood sugar. Diabetes, which is absolutely lacking in insulin, is called insulin-dependent diabetes, and diabetes, which is secreted but insufficient in action, is called insulin-independent diabetes. It is not easy to distinguish diabetics from these insulin-dependent or non-dependent forms. Current methods of treating diabetes are divided into diet, exercise, drug therapy, and insulin injection. Pancreas transplantation is also being attempted.

Insulin injection is the treatment used in insulin-dependent diabetics, but it can also be effective in insulin-independent patients. Insulin injection is a common method of receiving insulin injections 1-2 times a day, but the amount of insulin secreted in the human body is not constant, so a large amount is secreted three times before and after meals and less at other times. Injecting an average of 2 to 2 injections with low insulin after meals, high blood sugar on the contrary, the amount of insulin at night is low blood sugar is high. That is, there is a disadvantage that the body is abnormal because the insulin supply is abnormal. Therefore, the reason why the conventional insulin injection method did not help in preventing the diabetic complications was because it did not provide the change of insulin secretion of normal people. Therefore, a more improved treatment method is a so-called insulin pump (mechanical artificial pancreas) and pancreatic beta-cell transplantation method that control the amount of insulin injected by computer to make it close to normal insulin secretion in the human body.

In general, a long-term injection auto-injector (called an insulin pump, insulin syringe, insulin auto-injector, etc.) has a structure in which a push means for pushing a syringe piston into a housing for receiving an injection syringe is coupled. This can exemplify JP-A-52-3292 and US Pat. No. 4,417,889.

Taking the recently developed domestic patent registration No. 10-0353229, for example, when refilling the injection liquid in the syringe after use, the rotating shaft is separated from the housing, and the position is easily set by visually setting the position. As a portable auto-injector, the syringe using the conduit 1 connected to the connector 2 as shown in FIG. 1 is connected through the cover 110, and the cover 110 is sealed to the upper end of the housing 120. Combined. The housing 120 corresponding to the cover 110 includes a syringe 21, a piston 122, a piston push means 150, and a rotation shaft 131 for providing power through the power providing means 130. The housing 120 has a control button 123 for commanding a control board (not shown), a display unit 124 such as an LCD for displaying a control state, and a battery cover 125 for fixing a battery for supplying power. ) And a reset button 121 for performing a reset function. 140 is a bottom cover.

FIG. 2 is a plan view of FIG. 1 and has a battery cover 125, a reset button 121, a cover 110, and a connector 2 connected to the cover 110 on a top surface of the housing 120. 2) has a configuration in connection with the conduit (1).

FIG. 3 is a plan view showing a structure in which the piston 122 and the push means 150 are placed and the power transmission means with the cover 110 of FIG. 2 omitted, and FIG. 4 is a cross-sectional view taken along line VII-X of FIG. In the lower center of the syringe holder 126 of the housing 120, a locking rotator 132 connected to the power supply unit 130, and a push means guide groove 25 for guiding the push means 150 to rise. And a piston guide groove 27 for guiding the linear vertical movement of the piston 122. The power providing means 130 and the locking rotator 132 are installed in the power providing means housing 130-1, and the power providing means housing 130-1 is coupled to the lower end of the housing 120.

FIG. 5 is an enlarged partial perspective view illustrating a coupling structure between a locking rotor 132 formed in the syringe holder 126 of the housing 120 and a rotating shaft 131 that is powered through the housing 120. A power supply means housing 130-1 is detachably coupled; A cross groove formed to be detachably coupled to the gear 132-3 coupled to the output end of the power providing means 130 and the coupling pin 133 of the rotary shaft 131 which is integrally formed with the gear 132-3. A locking rotor 132 having a 132-1; A rotating shaft (131) having a coupling pin (133) coupled to and separated from the cross groove (132-1) at a lower portion to linearly move the push plate (154) of the push means (150); A piston edge protrusion 122-2 which is screwed with the rotary shaft 131 and guides the push plate 154 along the push means guide groove 25 so as to be movable; and a piston edge integral with the piston 122 ( A piston edge having a push plate engaging projection 151-1 engaging with the push plate engaging groove 122-3 of 122-1 and a piston edge protrusion 122-2 guided along the piston guide groove 27. A piston 122 having a 122-1; It consists of a syringe 21 for supplying the injection liquid received along the piston 122 to the conduit 1 shown in FIG. The locking rotary ball 132 and the coupling pin 133 forms a coupling means. The power providing means (130-1) forms a guide ring plate (130-2) on a ring with an open top, and the guide ring plate (130-2) is a cross-shaped groove (132-) forming a locking rotary hole (132). Rotating shaft coupler 132-4 forming 1) is coupled.

FIG. 6 is an exploded perspective view illustrating the separated rotating shaft 131, the push means 150 coupled thereto, the piston 122, and the syringe 21, and FIG. 7 is a cross-sectional view illustrating a coupled state. 131 is made of a screw rod, the lower end of the rotary shaft 131 is formed integrally with the coupling pin 133 is coupled to the cross-shaped groove (132-1), the upper end of the cap screw for screwing the rotary shaft 131 (cap type) The head 131-1 is coupled. Push means 150 is screwed to the rotating shaft 131 to be movable. Push means 150 is a push plate 154 for screwing in the form of a nut and the rotating shaft 131, and a horizontal protrusion on the push plate 154 to engage with the push means guide groove 25 shown in FIG. Push plate guide protrusion 151, push plate coupling protrusion (151-1) coupled with the push plate coupling groove (122-3), the insertion protrusion (155) for fitting the piston 122, the insertion projection ( And a snap ring groove 156 on the ring formed in 155. A piston ring 122-4 is formed in the piston 122 corresponding to the snap ring groove 156. The piston 122 is coupled to the piston 122 for discharging the contents of the syringe 21 by a piston action, the piston edge 122-1 is formed at the lower end of the piston 122, the piston edge 122- Piston edge protrusion 122-2 is protruded in 1). The piston edge 122-1 also forms a push plate engaging groove 122-3 engaged with the push plate engaging protrusion 151-1.

8 shows that the lower gear shaft 132-5 of the reduction gear mechanism output side gear 132-3 constituting the power transmission means 130 is adhered to the gearbox lower plate 130-3 through the shaft hole 130-5. , Rotating shaft coupler 132-4 on the top of the gear 132-3 is integrally coupled with the rotating shaft 131. The gearbox lower plate 130-3 is integrally coupled with the power supply housing 130-1, and the lower gearbox lower plate 130-3 is coupled with the bottom cover 140, and the means for coupling the screw is coupled with the screw. It can be implemented in various ways such as hook or hook.

9 is a block diagram showing an example of the control circuit of the syringe, a control button unit 123 for controlling the control, a control unit 170 of the microcomputer function for recognizing the operation of the control button unit 123, and the recognized A display unit 124 for outputting and displaying data, a ROM 165 for storing various data and programs, a motor driver 167 for driving the motor 168 by the control output of the controller 170, The motor 168 in which the rotational force is controlled by the motor driver 167 and the photo coupler 169 sensing the rotational force of the motor 168 may be illustrated. As a preferable example of the control unit 170, the first and second control units 171 and 172 having the same function may be configured so that the function can be continued even if at least one occurs. Terminals P1-P5 and P1 ′ -P2 ′ shown in the controllers 171 and 172 are ports connected to data and / or bus lines. The motor 68 may exemplify a stepping motor, a servo motor, or the like. The control unit 170 shows a graph of injecting insulin to interlock with a blood glucose level that increases with meal time as shown in FIG. 10. Using this principle, the control unit 170 controls the supply of insulin injection solution.

However, these types of syringes function to allow the output shaft and the piston to work together after decelerating the power of the motor through a gear mechanism, so that when the syringe or syringe is moved, the injection fluid does not move and the load on the piston increases. In some cases, the gear mechanism may be damaged, and in reality, the catheter is blocked and the injection solution is not supplied. However, when the user or doctor judges that the injection solution is injected, the patient may cause a fatal danger to the patient.

The present invention is to solve this, an object of the present invention is to provide a power to the rotary shaft, the rotary shaft to recognize the load applied to the rotary shaft when the piston does not rise below the rotary shaft of the insulin auto-injector for vertical movement of the piston The intent is to provide an auto-injector that can detect clogging of the fluid and stop it.

To this end, the present invention is to install a pressure sensor for recognizing the pressure fluctuations due to the lowering of the rotating shaft in the lower part of the rotary shaft to apply the rotary motion to the piston in a linear motion under the power of the insulin auto-injector, and when the injection fluid is clogged It can not recognize the clogging of the injection due to the generation of pressure applied to the lower end of the rotation axis relative to the upward movement.

In other words, the present invention is to receive a syringe in the housing, coupled to the syringe for receiving the automatic injection piston, the piston in the insulin auto-injector made to operate through the power supply means driven by the control unit,

A pressure sensor for recognizing the downward pressure of the rotating shaft is placed in the lower part of the rotating shaft which is powered by the power supply means of the insulin auto-injector to make the piston move vertically.

The operation of the pressure sensor is to be recognized by the control unit, and to provide an automatic syringe capable of detecting the clogging of the injection liquid to alert that the injection liquid is blocked when excessive pressure is generated.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

11 is a main configuration diagram of the present invention, the lower gear shaft 132-5 of the gear reduction gear output side gear 132-3 constituting the power transmission means 130 is the gearbox lower plate (through the shaft hole 130-5); 130-3, the rotary shaft coupler 132-4 on the top of the gear (132-3) is integrally coupled with the rotary shaft 131. The gearbox lower plate 130-3 is integrally coupled with the power supply housing 130-1, and the lower gearbox lower plate 130-3 is coupled with the bottom cover 140, and the means for coupling the screw is coupled with the screw. It can be implemented in various ways such as hook or hook. The pressure sensor 200 is installed between the gearbox lower plate 130-3 and the bottom cover 140, and the shaft hole 130-5 communicates with the pressure sensor 200, and the gear shaft 132-5. ) Is configured to reach the pressure sensor 200 through the shaft hole (130-5). It is preferable to form a jaw portion 132-6 that blocks the excessive lowering of the gear shaft 132-5 at the lower portion of the output side gear 132-5 and the gear shaft 132-5.

12 is a block diagram of the present invention, which includes a control button 123 for instructing control, a control unit 170 of a microcomputer function for recognizing operation of the control button 123, and outputting and displaying the recognized data. The display unit 124, the ROM 165 storing various data and programs, the motor driver 167 driving the motor 168 by the control output of the controller 170, and the motor driver 167. By way of example, the motor 168 in which the rotational force is controlled and the photo coupler 169 sensing the rotational force of the motor 168 may be illustrated. As a preferable example of the control unit 170, the first and second control units 171 and 172 having the same function may be configured so that the function can be continued even if at least one occurs. Terminals P1-P5 and P1 ′ -P2 ′ shown in the controllers 171 and 172 are ports connected to data and / or bus lines. The motor 68 may exemplify a stepping motor, a servo motor, or the like.

The first controller 171 is configured to receive the sensing value through the pressure sensor 200 through the terminal (P6). Reference numeral 210 is a buzzer that operates to know an alarm through the terminal P0 of the controller 171.

The present invention thus constructed has the same function as a general insulin autoinjector, but when used, the syringe 21 or the conduit 1 is clogged and the injection solution is theoretically supplied, but is not actually blocked. In this case, when the rotary shaft 131 receives the power through the power transmission means 130 and rotates, the piston 122 coupled with the push means 150 for converting the rotary motion of the rotary shaft 131 into the upward linear motion is raised. , But acts to supply the injection liquid of the syringe 21, for example, when the outlet of the syringe 21 is blocked, the rotary shaft 131 and the push means 150 is overloaded each other, which means that the rotary shaft 131 is push means ( The repulsive force of 150 causes a force below the gear shaft 132-5 of the gear 132-3 shown in FIG. 8 to form the power providing means 130. In this case, the shaft hole 130-5 to which the gear shaft 132-5 is rotatably coupled is made to penetrate the upper and lower surfaces thereof, and the pressure sensor 200 and the gear shaft placed on the bottom cover 140 at the lower portion of the penetrating shaft. The lower end of 132-5 is made to abut. By using the present invention, the pressure sensor 200 is installed at the lower end of the gear shaft 132-5 as shown in FIG. 11 so that the injection of the injection liquid can be determined by whether or not the pressure of the pressure sensor 200 is generated. Specifically, when the gear shaft 132-5 is overloaded (when the outlet of the injection liquid is blocked and the supply is blocked), pressure is generated by pressing the pressure sensor 200, which causes the terminal P6 of the control unit 171 to be closed. The control unit 171 recognizes and operates the buzzer 210 which is an alarm means through the terminal P0 and simultaneously displays the alarm contents on the display unit 124. Of course, the present invention can reduce the error by determining the abnormality by simultaneously recognizing the rotational speed of the motor 168 through the photocoupler 169 in order to reduce the operation error (if the output of the photocoupler is abnormal, this is the motor 168 Outputs the proper number of revolutions), but it does not rotate properly due to mechanical abnormalities (clogging of the injection solution, etc.). The user then recognizes and stops operation, replaces the injection conduit, checks the syringe, or replaces and repairs the blockage for normal use. Of course, the simple thing is the user, but if you do not know where the blockage, you can get the doctor or the manufacturer's Ace.

When the excessive pressure is generated in this case (in this case, when the pressure sensor 200 outputs an excessive pressure generation signal and recognizes it by the controller 171), the excessive pressure is generated so that the pressure sensor 200 may be damaged. In view of the fact that the present invention puts the jaw portion 132-6 on the gear shaft 132-5, the gearbox lower plate 130- 130 is placed on the jaw portion 132-6 even when the rotation shaft 131 falls when excessive pressure is generated. 3) It prevents further pressure from being applied to the pressure sensor 200 by touching the upper surface, and functions to operate stably.

As described above, the present invention supplies an injection liquid through a syringe, and in the insulin autoinjector supplying the injection liquid of the syringe to a piston moving vertically in conjunction with the rotating shaft, when pressure is generated at the bottom of the rotating shaft (the supply of the injection liquid is blocked. Since the block is overloaded, when the force is generated due to the overload of the rotating shaft), it is recognized by the controller through the pressure sensor that recognizes it, and the alarm is sounded. Allow the provision of a syringe.

In addition, the gear shaft that pressurizes the pressure sensor to actuate the jaw portion has a gearbox that provides a shaft hole in which the gear shaft rotates and abuts at high pressure to prevent damage of the pressure sensor, thereby improving durability of the pressure sensor.

Claims (3)

delete In the insulin auto-injector, which receives the syringe in the housing, couples the injection syringe to the injection syringe, and the piston is operated through a power supply means driven by the control unit. A pressure sensor for recognizing the downward pressure of the rotating shaft is placed in the lower part of the rotating shaft which is powered by the power supply means of the insulin auto-injector to make the piston move vertically. The operation of the pressure sensor is recognized by the control unit that controls the automatic scanning, and when excessive pressure is generated, it alerts that the injection liquid is blocked. The lower part of the rotating shaft 131 is coupled to the output side gear 132-3 constituting the power providing means 130, and the lower side of the rotating shaft 131 at the lower end of the output gear shaft 132-5 of the output side gear 132-3. Automatic injection syringe capable of detecting the clogging of the injection, characterized in that the pressure sensor 200 to recognize the pressure is installed. 3. The output gear shaft (132-5) below the output gear (132-3) has a jaw portion (132-6) for preventing excessive drop of the output gear shaft (132-5). Automatic syringe which can detect clogging of injection liquid.

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