KR20010044514A - Hand cleanser containing alcoholic gel and preparation the same - Google Patents

Abstract

PURPOSE: Provided is a gelated hand cleaning agent of lotion type or paper towel type, which contains alcohol, triclosan, and para-chloro-meta-xylenol(PCMX) for sterilization and antimicrobial action. CONSTITUTION: The hand cleaning agent comprises 60-68 volume% of ethanol; 2-5 volume% of isopropanol; 0.1-0.3 wt.% of carbomer as a gelating agent; 0.2-0.3 wt.% of the triclosan; 1-3 volume% of the PCMX; 0.1-0.15 volume% of amino methyl propanol for producing the gelated cleaning agent having a viscosity of 10,000-15,000 CPS controlled by neutralizing and curing carboxyl groups in the acrylic acid of the carbomer; and at least one auxiliary agent selected from the group consisting of 2-4 volume% of glycerin, 2-4 volume% of propylene glycol, 0.5-1 volume% of isopropyl myristate, 0.1-0.3 volume% of tocopherol, and 0.1-0.3 volume% of polysorbate 20 as a surfactant.

Description

HAND CLEANSER CONTAINING ALCOHOLIC GEL AND PREPARATION THE SAME}

The present invention is convenient to use without water, soap and towel, while gelling the liquid while maintaining the disinfecting power of the alcohol and the antibacterial properties of triclosan and PCMX so as to be convenient to carry and use, regardless of time and place. Start hand cleaner. It also provides a method for preparing this hand cleaner.

The cause of microbial contamination of food may be environmental factors, contamination by food workers, contamination by raw materials and food itself. Food workers and improper hand washing often contaminate food or other raw materials and utensils.

Therefore, as a hand washing method to minimize microbial contamination of foods by hand, gelling liquids while maintaining the antimicrobial power of alcohol and triclosan and PCMX, efficient hand sterilization which is convenient to carry and use anywhere, anytime without water, soap and towel You must maintain the health of yourself and others.

Conventionally, hand sanitizers contain antibiotics in soap-like preparations to disinfect hands when washing, and detergents, water, towels, paper towels, etc. must always be present. Often used.

Bacteria are usually classified into resident bacteria and transient bacteria in the skin, and about 90% of them are Gram-negative bacteria. On the other hand, non-existent microorganisms are the most problematic microorganisms in food and are easily removed by hand washing using soap and water or by disinfectant.

Hand washing detergents and disinfectants are generally known as soaps, especially antibacterial soaps with antibacterial effects, chlorhexidine, alcohols, iodine fungicides, para-chloro- meta-xylenol (PCMX) and triclosan.

In this background, one example of a known technique for hand sanitizing detergent is a volatilizing detergent disclosed in Korean Patent Laid-Open No. 2000-64060. It contains 60-73% ethyl alcohol, 0.1-0.24% acrylic acid, 4.0-5.0% triethanolamine, 0.01-0.02% carbomer, 1-3% PCMX and 2.5-3.5% aloe vera. It is a homogeneously mixed composition, diluted to 10-15% by volume of purified water, and used as a gel or lotion type. The complex toxic compound of ethyl alcohol and PCMX not only has excellent sterilizing effect, but also because of the volatilization of alcohol, it does not need to be cleaned naturally with towels or paper towels after washing because it is naturally dried in a few seconds, and it can also prevent skin drying with aloe vera ingredients. It is a detergent.

Another known technique is the antimicrobial alcohol gel disclosed in US Pat. No. 4,956,170. It is a high alcohol content antimicrobial gel composition, based on the total weight, ethanol 60-75%, thickener 0.4-2%, diisopropanol neutralizer 15-100%, hydrocarbon emollient 0.5-2.5% and other fatty acid esters, fatty alcohols And a gel-like composition having a viscosity of about 10,000-100,000 CPs as a composition comprising polyhydric alcohol and the like and containing at least 20% water as the remainder. The composition has an antimicrobial effect, which is useful for use as a hand cleaner in a hospital, and is also easily dried due to the volatility of the alcohol contained therein, while the skin lubricating ingredient remains on the skin to prevent roughness.

Based on the above known technology, the present invention adds another specific compound or co-additive in addition to utilizing the volatility and sterilizing power of alcohol to improve the gelling action of the liquid composition and to have a proper viscosity, so that a lotion or cream form hand A composition suitable for producing a detergent product or a product in the form of mineral oil and a hand cleaner containing the composition.

1 is a microscopic picture of a sample taken from a hand immediately after washing with a hand cleaner composition of the present invention (about 15 seconds after washing);

2 is a microscopic picture of a sample taken from a hand after 30 seconds of rinsing and without wiping with the hand cleaner composition of the present invention;

3 is a micrograph showing the results after 1 minute has elapsed under the same conditions as FIG. 2;

4 is a micrograph showing the result after 5 minutes in the same conditions as in FIG. 2;

Figure 5 is a microscopic picture of a sample taken from the hand before washing as carried out for the purpose of comparing with the bactericidal effect of the hand cleaner of the present invention; And

6 is a microscopic picture of a sample taken from a hand immediately after washing with a towel after washing hands with water and soap as another comparative example.

Hand cleaner according to the present invention contains triclosan and PCMX for antimicrobial effect, and also gelled liquid by volatility of alcohol component, so it is convenient to use without water, soap, towel.

The triclosan is known to have a wide and rapid bactericidal effect on gram-positive and most gram-negative bacteria and is hardly affected by organic matter. In particular, 1.5% triclosan has a sustained bactericidal effect against non-existent bacteria.

On the other hand, PCMX is known to be effective against Gram-positive microorganisms but less effective to Gram-negative bacteria. It has a particularly good effect on viruses, some fungi and Mycobacterium tuberculosis, and lasts for several hours without being affected by organic matter.

The hand cleaner composition of the present invention will be described in more detail as follows.

end. The bactericidal power of alcohol is maximum when it is 70 vol% aqueous solution, and it is known that the disinfection or sterilization power is little at 60 vol% or less and 80 vol% or more. Thus, the present invention contains 60-70% of the total content of ethanol and isopropanol.

I. On the other hand, 0.2.-0.3% by weight of "carbomer" (trade name "Carbopol Ultrez 10" RFGoodrich) is added for the gelling reaction of the composition.

All. It is also more effective than simple alkaline components to add amine compounds such as triethanolamine, aminomethyl propanol, aminomethyl propanediol to neutralize the acrylic acid carboxyl groups. However, in the case of triethanolamine, to obtain the desired viscosity, the amount of the total composition ratio needs to be changed to some extent.Aminomethyl propanediol has a higher molecular weight than aminomethyl propanol and has a melting point of 110 ° C. Very high in comparison, not suitable for use.

Therefore, preferably 0.1-0.15% by volume of aminomethyl propanol, which is a curing accelerator used to impart a suitable viscosity to make products of the general cream or lotion type or mineral oil type using the composition of the present invention, is added.

la. Add 0.2-0.3% by weight triclosan: As mentioned earlier, triclosan has a sustained bactericidal effect against non-existent bacteria. Until recently, home care products such as toothpaste, deodorant soaps, deodorants, antiperspirants, body washes, detergents, dishwashing agents, cosmetics, antibacterial creams and lotions, wash soaps It is contained in a lot. As another component, PCMX can be added by volume by 1-3 vol%. In addition, it is also possible to use other known alternative antibiotic components that can obtain the antimicrobial effect as described above.

hemp. 70% by volume of alcohol prevents the skin from roughening due to the reduction of various alcohol decomposing components and moisture in the skin and adds the components necessary for homogenization of the composition. Examples of such components include the following. The composition of each component is based on volume:

-Moisturizer: 1-2% glycerin, 1-2% propylene glycol

Ester oil: 0.5-1% isopropyl myristate

Vitamin: 0.01-0.02% Tocopherol

Surfactant: 0.1-0.3% Polysorbate 20

The hand washing composition prepared as described above may be manufactured and applied to various products, and some specific examples are as follows.

A) Portable product: Prepared at 0.2-0.25% by weight carbomer concentration to maintain a viscosity of more than moderate, and put in a 50-60ml container. The container is equipped with a 'one-touch' lid, which is convenient for carrying and when and wherever.

B) Table top product: Manufactured in a concentration of 0.15-0.2% by weight carbomer to maintain a viscosity of less than or equal to and contained in a 400-500 ml container. The container is equipped with a pump-type lid and placed on a table at home or a restaurant for convenient use.

C) For wall mounting: Maintain high viscosity at 0.25-0.3 wt% carbomer concentration and place in 800ml wall-mounted container (water soap container, etc.) so that it does not flow down despite the nozzle mounted downward at the bottom of this container.

D) For Body Wash: 0.1-0.15% carbomer and 60% by volume ethanol to weaken the viscosity and alcohol odor, soaked in paper towels and packed in plastic packs for people with chronic diseases and behavioral delays. Clean your body easily and comfortably without soap, towels, etc.

Table 1 comparing the composition and composition of the composition of the present invention as described above and the known composition according to the conventional literature is listed as follows.

TABLE 1

Composition 1 = U.S. Patent 4,956,170 (September 11, 1990)

Composition 2 = Korean Patent Publication No. 2000-64060 (November 6, 2000)

Composition 3 = a composition of the present invention.

TABLE 1

division Composition 1 Composition 2 Composition 3 Remarks Alcohol 60-75 60-73 60-70 Water composition should be 25-28% Carbomer 0.4-2 0.01-0.02 0.1-0.3 Carbomer is a polymer that combines allyl ester of acrylic acid and allyl sucrose or pentaerythritol. Acrylic acid - 0.1-0.24 - corrector Diisopropanol amine Triethanolamine Aminomethyl propanol Diisopropanolamine and aminomethyl propanol are the same compound. Antibiotic - 1-3 PCMX 0.2-0.3 Triclosan 1-3 PCMX PCMX: Effective for Gram-positive bacteria. Triclosan: Effective for Gram-positive and negative bacteria. Moisturizer 1-6 glycerin or propylene glycol 2.5-3.5 aloe 1-2 glycerin and 1-2 propylene glycol Composition 1 is either glycerin or propylene glycol, but composition 3 adds both. Surfactants 0.05-1 - 0.1-0.3 polysorbate Composition 1 refers to all general nonionic surfactants. Ester oil 0.5-2 0.5-1 isopropyl myristate Composition 1 refers to the overall fatty acid ester. vitamin - - 0.1-0.3 Vitamin E (Tocopherol)

* Composition is volume% for liquid and weight% for solid.

* Composition 1 is for additives except alcohol and carbomer (the cosmetic ingredients are all mentioned)

As can be seen from the table, the composition of the present invention contains carbomer in a specific composition, that is, 0.1-0.3%, contains triclosan and PCMX as antibiotics, and also contains compounds such as moisturizers, surfactants, and ester oils as adjuvants. Has characteristics.

In addition, it is easy to carry and use by maintaining the proper viscosity, you can feel the moisture and softness of the skin as a moisturizing and skin protection ingredient after use.

The bactericidal effect of the above-described hand cleaner composition of the present invention was tested as follows.

EXAMPLE

The bactericidal effect of the hand cleaner composition of the present invention was examined and measured over time, for example, immediately after washing (about 15 seconds after washing), 30 seconds, 1 minute, and 5 minutes after washing. . In addition, for the purpose of comparison with the results, the results shown immediately after washing with a towel after washing with water and soap before washing hands are summarized as shown in Table 2 below.

TABLE 2

Experimental condition drawing Bacterial colony Immediately after washing with the composition of the present invention (about 15 seconds elapsed) 1 none About 30 seconds after washing with the composition of the present invention 2 Generating 1-2 Small Clusters About 1 minute after washing with the composition of the present invention 3 Generating 3-7 Small Clusters About 5 minutes after washing with the composition of the present invention 4 Producing 1 large cluster and 10-17 small clusters Before washing your hands 5 Large community multiple beings After washing with soap and towel 6 Reduced to about a quarter of the number of bacteria in FIG.

Referring to the above experimental results and drawings, the composition of the present invention was found to be very effective, and in particular, a significant bactericidal effect was maintained from just after washing to 5 minutes. Furthermore, it is noted that the above bacterial colony count was measured using the hand as usual, that is, not in a clean state after washing with the composition of the present invention, but in a daily life. It is a result.

On the other hand, after washing 5 minutes after washing with water and soap as a result of the hand inspection, similar to the composition of the present invention, one large colony and 10-20 small populations, but after cleaning, observed This is the case where the clean state is maintained differently from the conditions of the present invention using the hand routinely. Therefore, when washed with soap and water and wiped with a towel, it is judged that it does not show the same effect as when using the composition of this invention.

The composition of the present invention prepared as described above contains 60-70% by volume of ethanol, 0.2-0.3% by weight of triclosan and 1-3% by volume of PCMX through the antibacterial activity of alcohol and the wide range of antibacterial activity of triclosan and PCMX, various bacterial contamination of the hands It can remove more than 99.99% and it is very convenient because it doesn't need water, soap, towel, etc. due to volatile ethanol.

Claims (5)

A high disinfectant composition comprising 60-68% ethanol and 2-5% isopropanol, 0.1-0.3% by weight carbomer as gelling agent. The method of claim 1, A high disinfectant composition, characterized in that 0.1-0.15% by volume aminomethyl propanol is added as an agent to neutralize and cure the acrylic acid carboxyl group of carbomer to prepare a gelate of 10,000-15,000 CPS viscosity. The method of claim 1, A high disinfectant composition, characterized by adding 0.2-0.3 wt% triclosan and 1-3 vol% PCMX. The method of claim 1, When the alcohol comes into contact with the skin, it reduces the roughening of the skin by reducing various alcohol decomposing components and moisture contained in the skin, and as a moisturizing agent, 2-4% by volume glycerin, 2-4% by volume propylene glycol, and 0.5- At least one adjuvant selected from the group consisting of 0.1-0.3 volume% polysorbate 20 as surfactant to maintain homogenization of 1 volume% isopropyl myristate, 0.1-0.3 volume% tocopherol and the composition High bactericidal composition. 60-68 vol% ethanol and 2-5 vol% isopropanol, 0.2-0.3 wt% carbomer, 0.2-0.3 wt% triclosan and 1-3 vol% PCMX, 10,000-15,000 CPS viscosity as gelling agent 0.1-0.2% by volume aminomethyl propanol for neutralizing and curing the acrylic acid carboxyl group of carbomer, 2-4% by volume glycerin, 2-4% by volume propylene glycol, 0.5-1%, which is a common moisturizer for preventing skin dryness Lotion and paper, characterized in that it comprises a high disinfectant composition containing at least one adjuvant selected from the group consisting of% isopropyl myristate, 0.1-0.3 volume% tocopherol and 0.1-0.3 volume% polysorbate 20 as a surfactant. Towel-type hand sanitizer.