KR20010022924A - 페네틸아민 유도체 - Google Patents

페네틸아민 유도체 Download PDF

Info

Publication number
KR20010022924A
KR20010022924A KR1020007001529A KR20007001529A KR20010022924A KR 20010022924 A KR20010022924 A KR 20010022924A KR 1020007001529 A KR1020007001529 A KR 1020007001529A KR 20007001529 A KR20007001529 A KR 20007001529A KR 20010022924 A KR20010022924 A KR 20010022924A
Authority
KR
South Korea
Prior art keywords
group
tbu
tyr
phe
mmol
Prior art date
Application number
KR1020007001529A
Other languages
English (en)
Korean (ko)
Inventor
고따께겐-이찌로
고조노도시로
사또쯔또무
다까나시히사노리
Original Assignee
나가야마 오사무
쥬가이 세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 나가야마 오사무, 쥬가이 세이야쿠 가부시키가이샤 filed Critical 나가야마 오사무
Publication of KR20010022924A publication Critical patent/KR20010022924A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
KR1020007001529A 1997-08-15 1998-08-14 페네틸아민 유도체 KR20010022924A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP25587997 1997-08-15
JP97-255879 1997-08-15
JP98-186802 1998-05-28
JP18680298 1998-05-28
PCT/JP1998/003627 WO1999009053A1 (fr) 1997-08-15 1998-08-14 Derives de phenylethylamine

Publications (1)

Publication Number Publication Date
KR20010022924A true KR20010022924A (ko) 2001-03-26

Family

ID=26503986

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007001529A KR20010022924A (ko) 1997-08-15 1998-08-14 페네틸아민 유도체

Country Status (10)

Country Link
US (1) US6255285B1 (US06255285-20010703-C00106.png)
EP (1) EP1006122B1 (US06255285-20010703-C00106.png)
KR (1) KR20010022924A (US06255285-20010703-C00106.png)
CN (1) CN1272114A (US06255285-20010703-C00106.png)
AT (1) ATE416186T1 (US06255285-20010703-C00106.png)
AU (1) AU741216B2 (US06255285-20010703-C00106.png)
CA (1) CA2301687A1 (US06255285-20010703-C00106.png)
DE (1) DE69840296D1 (US06255285-20010703-C00106.png)
TW (1) TW460478B (US06255285-20010703-C00106.png)
WO (1) WO1999009053A1 (US06255285-20010703-C00106.png)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0639374T3 (da) * 1993-06-28 2002-05-06 American Home Prod Nye behandlingsmetoder ved anvendelse af phenethylderivater
US6329372B1 (en) * 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
TW509699B (en) * 1998-09-24 2002-11-11 Chugau Pharmaceutical Co Ltd Ethylamine derivatives
WO2000044770A1 (fr) * 1999-01-28 2000-08-03 Chugai Seiyaku Kabushiki Kaisha Derives phenethylamine substitues
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6511980B2 (en) 2000-05-05 2003-01-28 Ortho Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
GB0030304D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
EP1312612A4 (en) * 2000-08-24 2004-09-22 Chugai Pharmaceutical Co Ltd CYCLIC PEPTIDE DERIVATIVE
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
WO2002057791A2 (en) * 2000-11-29 2002-07-25 Lifespan Biosciences, Inc. Diagnostic and therapeutic compositions and methods related to grp 38
WO2002059141A1 (fr) * 2001-01-25 2002-08-01 Chugai Seiyaku Kabushiki Kaisha Derives peptidiques
CA2442654A1 (en) * 2001-04-10 2002-10-10 Transtech Pharma, Inc. Probes, systems, and methods for drug discovery
TNSN03146A1 (fr) * 2001-06-28 2005-12-23 Pfizer Prod Inc Indoles, benzofurannes et benzothiophenes a substituant triamide, utiles comme inhibiteurs de secretion de la proteine de transfert des triglycerides microsomaux et/ou de l'apolipo-proteine b (apo b).
US7338939B2 (en) * 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
US7375082B2 (en) * 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US20070066537A1 (en) * 2002-02-22 2007-03-22 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
CN1939529A (zh) * 2002-01-29 2007-04-04 Wyeth公司 用于调节连接蛋白半通道的组合物和方法
CA2477004C (en) * 2002-02-22 2011-05-10 Thomas Piccariello Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
US7659253B2 (en) 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
EP1481078A4 (en) * 2002-02-22 2006-08-16 New River Pharmaceuticals Inc USE OF A PEPTIDE DRUG CONJUGATION TO REDUCE VARIABILITY OF MEDICAMENT SERUM MIRRORS BETWEEN PATIENTS
SI1644019T2 (en) * 2003-05-29 2018-04-30 Shire Llc AMPHETAMINE COMPOUNDS COMPOUNDS TO ABUSE
JP4928261B2 (ja) 2003-06-18 2012-05-09 トランザイム・ファーマ・インコーポレイテッド モチリン受容体の大環状拮抗薬
BRPI0414876A (pt) * 2003-09-30 2006-11-21 New River Pharmaceuticals Inc compostos e composições farmcêuticas para prevenção de overdose ou abuso e respectivos usos
EP2431380A3 (en) 2006-09-11 2013-07-03 Tranzyme Pharma, Inc. Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
KR20180084782A (ko) 2015-10-14 2018-07-25 엑스-써마 인코포레이티드 얼음 결정 형성을 감소시키기 위한 조성물 및 방법
CN112812334B (zh) * 2021-01-11 2022-06-17 浙江博菲电气股份有限公司 一种新能源电机用阻燃槽楔的制备工艺及阻燃槽楔

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003483A1 (en) 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
US5470830A (en) 1993-08-06 1995-11-28 Ohmeda Pharmaceutical Products Division Inc. Motilin-like polypeptides that inhibit gastrointestinal motor activity
JP3449766B2 (ja) 1993-11-19 2003-09-22 中外製薬株式会社 モチリンアンタゴニスト
WO1996040208A1 (en) * 1995-06-07 1996-12-19 Torrey Pines Institute For Molecular Studies Novel mu opioid receptor ligands: agonists and antagonists
US5712253A (en) 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
US6013633A (en) * 1997-08-07 2000-01-11 University Of Cincinnati Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm
US5972939A (en) 1997-10-28 1999-10-26 Ortho-Mcneil Pharmaceutical, Inc. Cyclopentene derivatives useful as antagonists of the motilin receptor
WO2000044770A1 (fr) * 1999-01-28 2000-08-03 Chugai Seiyaku Kabushiki Kaisha Derives phenethylamine substitues

Also Published As

Publication number Publication date
EP1006122A4 (en) 2004-10-13
TW460478B (en) 2001-10-21
AU8649098A (en) 1999-03-08
EP1006122A1 (en) 2000-06-07
CN1272114A (zh) 2000-11-01
US6255285B1 (en) 2001-07-03
DE69840296D1 (de) 2009-01-15
ATE416186T1 (de) 2008-12-15
AU741216B2 (en) 2001-11-29
EP1006122B1 (en) 2008-12-03
WO1999009053A1 (fr) 1999-02-25
CA2301687A1 (en) 1999-02-25

Similar Documents

Publication Publication Date Title
KR20010022924A (ko) 페네틸아민 유도체
US7589170B1 (en) Synthesis of cyclic peptides
US7084244B2 (en) Conformationally constrained backbone cyclized peptide analogs
Rodriguez et al. Synthesis and biological activity of partially modified retro-inverso pseudopeptide derivatives of the C-terminal tetrapeptide of gastrin
EP0804468B1 (en) Method of making an omega-functionalized amino acid derivative
CA2515975C (en) Peptide derivatives having .beta.-secretase inhibitory activity
EP0535155B1 (en) Libraries of modified peptides with protease resistance
RU2246501C2 (ru) Лиганды меланокортиновых рецепторов
AU4017900A (en) Melanocortin receptor ligands
KR20050034716A (ko) 성장 호르몬 방출 펩타이드
US7214769B2 (en) Method for inverse solid phase synthesis of peptides
JPH10510814A (ja) ベタイドを製造するためのアミノ酸並びにベタイドライブラリーのスクリーニング方法及び製造方法
DK154437B (da) Fremgangsmaade til fremstilling af pentapeptidet h-arg-x-z-y-tyr-r ved oploesningssyntese
US6468974B1 (en) Compounds having growth hormone releasing activity
US6184345B1 (en) Branched building units for synthesizing cyclic peptides
NZ246815A (en) Phenylalanine analogs of bombesin and compositions thereof
Williams et al. Cyclic peptides as selective tachykinin antagonists
JP3583928B2 (ja) フェネチルアミン誘導体
JPH08500331A (ja) タキキニンアンタゴニスト三環式化合物、その製造法並びにそれを含む医薬組成物
JP2000501083A (ja) 改善された作用効果を有する新規ｌｈ―ｒｈ―拮抗剤
JP2010150253A (ja) 肝癌を治療するための薬剤
US3847892A (en) Octapeptide solid phase-fragment process and pentapeptide intermediates
Ligeti et al. Synthesis of enzymatically resistant nociceptin‐related peptides containing a carbamic acid residue
SK136596A3 (en) New opioid peptide analogs with mixed mu agonist/delta antagonist properties
Anselmi Peptidomimetic ligands for tuning integrin-mediated signalling: rational design, synthesis and theranostic applications

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E902 Notification of reason for refusal
E601 Decision to refuse application