KR20000061633A - A cosmetic having hydrogel matrix adsheive sheet type - Google Patents

Abstract

PURPOSE: A hydrogel matrix adhesive sheath-type cosmetic stuff is provided, which makes the skin-effective beauty ingredients to be absorbed continuously through skin without skin-irritation, so enhances beauty effect of the ingredients. CONSTITUTION: A process for the preparation of hydrogel matrix adhesive sheath-type cosmetic stuff comprises of: adding water-soluble adhesive material to a solvent(e.g., distilled water); dissolving evenly while heating and shaking(A); dispersing beauty ingredient, emulsifier, stabilizer, antioxidant, and perfume into distilled water(B); mixing A with B; adding bridging agent dispersed in distilled water to the compound, and shaking till even state; making the compound to be vacuumed, and cooling; spreading the compound on the film-typed adhesive part protection layer in the 100-150micrometer thickness using coating machine; drying by passing tunnel with a fan at room temperature; combining with the exposed part protection layer to get the hydrogel matrix adhesive sheath type cosmetic composition.

Description

A cosmetic having hydrogel matrix adsheive sheet type

The present invention relates to a hydrogel matrix pressure-sensitive adhesive sheet-type cosmetics that can increase the cosmetic effect by allowing the skin to be absorbed continuously through the skin without the skin stimulation effective cosmetic ingredients. More specifically, the present invention is a hydrogel matrix comprising at least one hydrogel matrix layer containing an exposed site protective layer, an adhesion site protective layer and a cosmetic ingredient capable of imparting an effective cosmetic effect to the skin between the two layers. It relates to an adhesive sheet type cosmetics.

Generally, in order to give skin's beauty effects such as whitening, anti-wrinkle, moisturizing, elasticity, suppleness, supple cosmetics, astringent cosmetics, nourishing cosmetics, nutrition cream, massage cream, essence, eye cream, eye essence, pack, cleansing cream After cosmetic ingredients such as cleansing foam, cleansing water and powder have been used, they have been used.

However, the cosmetics applied to such existing skins have a disadvantage in that foreign matters are mixed during use or may be buried outside in contact with surrounding objects even after application. In addition, the unstable cosmetic ingredients that can be easily rancid in contact with the air has a disadvantage that it can not be added to the formulation at a high concentration in the existing cosmetics.

Therefore, conventional formulations using techniques such as microemulsion, multi-emulsification, microcapsules and the like have been actively researched and developed to solve these problems, but these formulations also come into contact with air when applied to the skin, thereby stabilizing the contents after application. There was a limit.

In addition, the method of destroying the lipid lamellae layer between the keratinocytes in the stratum corneum by using an excessive amount of a chemical skin absorption enhancer such as alcohol or a surfactant in order to absorb the cosmetic ingredients useful in the skin in effective concentrations on the skin. This method has been used, this method not only causes skin irritation but also difficult to quickly restore the original skin to its original state, there is a problem that may leave a scar on the skin in severe cases. In addition, the existing cosmetics have a problem to feel the skin abnormality after use, even when the user removes the contents have to be washed off.

In recent years, sheet cosmetics have been developed, not cosmetics applied. However, in the case of the formulations in which the nonwoven fabric of the sheet cosmetics is soaked in the cosmetic liquid to induce continuous absorption of the cosmetic liquid, the adhesion to the skin is low, and the cosmetic liquid is exposed to the air. It is difficult to avoid the degeneration of the cosmetic ingredients caused due to, there is a disadvantage that the occurrence of skin irritation due to the high concentration of cosmetic ingredients in contact with the skin is initially high.

Therefore, in order to overcome the shortcomings of such conventional cosmetics in Japan and abroad, research and development on the hydrogel matrix adhesive sheet-type preparations have been actively performed, and specific examples thereof are as follows.

That is, Japanese Patent Laid-Open No. 63-78199 discloses a preparation made by crosslinking an acrylic polymer with a metal salt, which has weak skin adhesion due to the property that the adhesive layer adhered to the skin is too hard and moisture easily evaporates. Has its drawbacks.

In addition, Japanese Patent Application Laid-Open No. 61-236600 discloses a formulation made of gelatin as a hydrogel matrix adhesive sheet type formulation having excellent prosthetic power and a feeling of ease of use, which has a low heat stability and a weak adhesive force. There is this.

In addition, Japanese Patent Application Laid-Open No. 58-167510 discloses a formulation using maleic anhydride as a formulation having excellent skin adhesion, and this formulation has a disadvantage in that it is too dry to be used as a cosmetic.

Accordingly, the present inventors have conducted a study to solve the problems of the existing cosmetics and problems of known hydrogel matrix adhesive sheet-type formulation, as a result, the hydrogel matrix adhesive sheet-type cosmetics exposed area protective layer, adhesion site protective layer And when the hydrogel matrix layer containing various cosmetic ingredients, water-soluble adhesives, crosslinking agents, emulsifiers and stabilizers is present between the two layers, the cosmetic ingredients effective for the skin can be blocked from the outside air. Lipid lamellar layer of the stratum corneum of the skin can be improved, and the adhesion to the skin is excellent because the water-soluble adhesive used in the general transdermal patch is used, and the cosmetics used contain a large amount of moisture. Is effectively absorbed into the skin It can be absorbed in, minimize the skin irritation and can continuously absorb the skin cosmetic ingredients to increase the cosmetic effect has been found to complete the present invention.

Therefore, an object of the present invention can increase the stability of the beauty ingredient effective on the skin, excellent adhesion to the skin, and can continuously absorb the beauty ingredient to the skin without skin irritation can achieve an increase in the beauty effect To provide a new hydrogel matrix adhesive sheet type cosmetics.

Figure 1 shows an example of a hydrogel matrix adhesive sheet type cosmetic according to the present invention.

〈Drawing code〉

1. Protective layer of exposed area 2. Hydrogel matrix layer 3. Protective layer of adhesion site

Figure 2 is a graph showing the guinea pig skin penetration of the retinol-containing hydrogel matrix adhesive sheet type cosmetics according to the present invention.

In order to achieve the above object, the hydrogel matrix adhesive sheet type cosmetic according to the present invention is composed of an exposed portion protective layer, an attachment portion protective layer and at least one hydrogel matrix layer formed between the two layers, the hydrogel matrix layer 0.01 to 30.0 wt% cosmetic ingredient, 0.01 to 70.0 wt% water soluble adhesive, 0.01 to 5.0 wt% crosslinking agent, 0.1 to 5.0 wt% emulsifier and 0.01 to 1.0 wt% stabilizer based on the total weight of the silver hydrogel matrix layer It is characterized by containing.

Hereinafter, the present invention will be described in more detail.

In the present invention, the hydrogel matrix layer is a cosmetic ingredient-containing layer that can be attached to the skin and delivers a cosmetic ingredient that can be applied to the skin to enhance the skin-cosmetic effect, and consists of a cosmetic ingredient, a water-soluble adhesive, a crosslinking agent, an emulsifier and a stabilizer. As used herein, the water-soluble pressure-sensitive adhesive is intended to enhance the adhesion of the skin, gelatin, water-soluble polyacrylate, polyvinyl alcohol, xanthan gum, gellan gum, sodium alginate, polyvinylpyrrolidone, polyvinylformamide or carboxymethyl At least one selected from the group consisting of cellulose is used. The amount of the water-soluble adhesive is 1.0 to 70.0% by weight based on the total weight of the hydrogel matrix layer.

Another component of the hydrogel matrix layer of the pressure-sensitive adhesive sheet-type cosmetics of the present invention is a crosslinking agent glyoxal; Zinc salts such as zinc oxide and zinc chloride; Aluminum salts such as aluminum glycinate and aluminum sulfate; Calcium salts such as calcium chloride and calcium oxide; Or one or more selected from the group consisting of magnesium salts such as magnesium chloride and magnesium oxide, and used in an amount of 0.01 to 5.0% by weight based on the total weight of the hydrogel matrix layer.

The emulsifier, another component of the hydrogel matrix layer, is to uniformly emulsify the components contained in the matrix layer and to enhance the skin absorption of the effective beauty ingredients. The polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyglycerol At least one selected from the group consisting of aryl fatty acids or fatty acid sugar esters is used. The amount of the emulsifier is 0.1 to 5.0% by weight based on the total weight of the hydrogel matrix layer.

Another component of the hydrogel matrix layer is a stabilizer for stabilizing the active cosmetic ingredients, at least one selected from the group consisting of citric acid, succinic acid, oxalic acid or formic acid. The amount of stabilizer used is 0.01 to 1.0% by weight based on the total weight of the hydrogel matrix layer.

Hydrogel matrix layer of the pressure-sensitive adhesive sheet-type cosmetics of the present invention may further contain an antioxidant to prevent the oxidation of the active cosmetic ingredients in addition to the above-described composition. Although the kind of antioxidant is not specifically limited, For example, the amount of butylhydroxytoluene (BHT), butylhydroxyanison (BHA) or a mixture thereof is 0.01 to 1.0% by weight relative to the total weight of the hydrogel matrix layer. It contains.

In addition, the hydrogel matrix layer of the pressure-sensitive adhesive sheet-type cosmetics of the present invention may further contain a fragrance in an amount of 0.001 to 1.0% by weight in addition to the above-described composition.

In order to keep the adhesive sheet-type cosmetics adhered to the skin for a long time and prevent foreign substances from adhering to the cosmetics, an exposed part protective layer is required. In the present invention, as the exposed site protective layer, any one used in the general transdermal patch application field may be used without limitation. That is, a woven fabric, a nonwoven fabric, or a polymer film is used as the exposed portion protective layer.

In the adhesive sheet-type cosmetics of the present invention, the adhesive layer protective layer may also be used without limitation to those used in the general transdermal administration patch. That is, a polypropylene film, polyethylene terephthalate film, polyvinyl chloride film or the like treated with fluorine or silicon can be used.

Hydrogel matrix adhesive sheet type cosmetic of the present invention is prepared by the following method. In other words. A water-soluble adhesive is added to a solvent, for example, purified water, heated and stirred to be uniformly dissolved, and then mixed with a dispersion of cosmetic ingredients, emulsifiers, stabilizers, antioxidants and fragrances in purified water. Then, when the dispersion of the crosslinking agent is dispersed in purified water, the stirring is stopped and vacuum degassed when the mixed solution is uniform, followed by cooling. It is applied to the protective layer on the film-like adhesive layer with a uniform thickness of 100 to 500 μm using a coating machine, and then dried at room temperature by passing through a tunnel equipped with a ventilation facility, and laminated with an exposed portion protective layer to form a hydrogel matrix adhesive sheet type cosmetic. Get

At this time, as needed, the hydrogel matrix layer having different kinds of beauty ingredients may be laminated in a multi-layered structure to adjust the skin absorption rate of the beauty ingredients useful for the skin.

The adhesive sheet-like cosmetics of the present invention prepared by the above method is aged for 12 to 48 hours in a room temperature or 37 ℃ thermostat and then cut into a shape that is easy to stick to the application site for final formulation.

As a cosmetic ingredient that can provide an effective beauty effect on the skin, the following may be applied to the adhesive sheet-type cosmetics.

Namely, retinol derivatives such as retinol and retinyl palmitate, retinyl acetate, retinoic acid and the like which are known as substances capable of inhibiting skin wrinkles; Polyhydric alcohols such as glycerin, butylene glycol, and propylene glycol, hyaluronic acid, sodium chondroitin sulfate, natto gum, skirt mushroom extract, various polysaccharides, natural amino acids, natural ceramides, and similar ceramides. Moisturizing ingredients; Natural plant extract components such as caffeine, hamamelis extract, and cornus extract known as substances which promote skin blood circulation; Ingredients such as carrot extract, marine collagen, vegetable collagen, and the like, which are known to improve skin elasticity; Vegetable oils such as vegetable squalene, meadowfoam oil, macadamia oil and olive oil known as substances having excellent skin softening effect, and synthetic oils such as mineral oil, silicone oil and ester oil; Ascorbic acid, ascorbic acid palmitate, ascorbic acid phosphate magnesium salt, a derivative of kojic acid and an alkyl group having 5 to 20 carbon atoms, and hydroquinone and its derivatives are known as substances having excellent skin whitening effect.

The amount of these cosmetic ingredients varies depending on the type of ingredients and the time of attachment of the cosmetics, but may be used in an amount of 0.01 to 30.0% by weight.

Hereinafter, although an Example and a test example are described in detail of this invention, this invention is not limited only to these examples.

<Examples 1 to 4>

Furtherance Example 1 Example 2 Example 3 Example 4 Ionized water 79.8 79.8 79.8 79.8 gelatin 2.0 2.0 2.5 2.5 Polyvinyl alcohol 3.0 - - - Polyvinylpyrrolidone - 3.0 3.0 3.0 Polyvinylformamide 2.0 2.0 2.0 2.0 Sodium alginate 1.0 - - - Carboxymethyl Cellulose - 1.0 - - glycerin 3.0 5.0 5.0 3.0 Guerlain Gum - - 1.0 - Retinol 2.0 - - - Hyaluronic acid 1.0 1.0 1.0 1.0 Ceramide 1.0 1.0 1.0 1.0 Caffeine 1.0 1.0 1.0 1.0 Carrot Extract - 3.0 3.0 3.0 Squalene 3.0 5.0 5.0 5.0 Kojic acid - 2.0 - - Polyoxyethylene (20) sorbitan stearate 1.0 1.0 1.0 1.0 Citric acid 0.1 0.1 0.1 0.1 Zinc oxide 0.1 0.1 0.1 0.1

<Examples 5 to 8>

Furtherance Example 1 Example 2 Example 3 Example 4 Ionized water 80.7 76.7 78.7 76.7 Polyvinyl alcohol 2.0 2.0 2.0 2.0 Polyvinylpyrrolidone 3.0 - - - Polyvinylformamide - 3.0 3.0 3.0 Sodium polyacrylic acid 3.0 5.0 3.0 5.0 Sodium alginate 1.0 - - - Carboxymethyl Cellulose - 1.0 - - Xanthan Gum - - 1.0 - Guerlain Gum - - - 1.0 Retinyl palmitate 1.0 1.0 1.0 1.0 Butylene glycol 3.0 5.0 5.0 5.0 Sodium Chondroitin Sulfate 1.0 1.0 1.0 1.0 Skirt Mushroom Extract 1.0 1.0 1.0 1.0 Meadowfoam oil 1.0 1.0 1.0 1.0 Macadamia Oil 1.0 1.0 - - Olive oil 1.0 1.0 - - Mineral oil - - 2.0 2.0 Polyoxyethylene (20) sorbitan stearate 1.0 1.0 1.0 1.0 Citric acid 0.1 0.1 0.1 0.1 Butylhydroxytoluene 0.1 0.1 0.1 0.1 Zinc oxide 0.1 - - Aluminum Glycinate - 0.1 - - Calcium chloride - - 0.1 - Magnesium chloride - - - 0.1

In the hydrogel matrix adhesive sheet type cosmetics prepared according to each example prescription, the skin absorption amount of the cosmetic composition of Example 1 containing retinol, the whitening effect of the cosmetic composition of Example 2 containing kojic acid, and the cosmetics of all the example prescriptions Examples of skin safety test for

<Test Example 1>

The abdominal hair of a male guinea pig, weighing about 350 g, was shaved with a hair clipper, and then cut at a portion and stored frozen at -20 ° C or lower. After installing the skin with the stratum corneum face up in the middle of the Franz type glass diffuser, 1.0% by weight of polyoxyethylene (60) cured castor oil and 50% by volume aqueous solution of glycerin are placed in the bottom space. The temperature of was maintained at 37 ° C. While the receptor solution was stirred at a constant speed (600 rpm), the hydrogel matrix adhesive sheet-like cosmetic of Example 1 was attached to the skin. At this time, the preparation is prepared in a circle so that the diameter is 2.5 cm 2. For comparison, another Franz-type glass diffuser was used to drop the cream containing 2% of retinol into the keratinized area through the diffuser lid by 1 ml with a pipette and seal the top of the lid.

After a certain time, the solution of the receptor portion was taken and supplemented with the buffered amount. The collected sample was measured by using high pressure liquid chromatography (HPLC) to measure the concentration of retinol, and from the measured data, the skin absorption of retinol was calculated and the results are shown in Table 1 and FIG. 2.

sample Skin absorption amount (㎍ / ㎠ / 3 hours) Skin absorption amount (㎍ / ㎠ / 3 hours) Retinol 2% cream 5.7 10.8 Example 1 (resinol 2% adhesive sheet type cosmetics) 2.7 13.6

From Table 1, the cream containing retinol 2% is initially absorbed by the excess retinol while the absorption tends to be lowered after 8 hours, which may cause skin side effects at the early stage, whereas the adhesion of Example 1 The sheet-like cosmetics are gradually absorbed into the skin from the beginning, so it is safe for the skin, and after 8 hours, the skin absorption amount is higher than that of the general coating cosmetics, and thus the effect can be further enhanced.

<Test Example 2>

Twenty healthy male and female experimenters were selected to select 2 × 2cm ² sites in the lower arm hips. Put aluminum foil on the arm so that ultraviolet rays are irradiated only on the test target area, and at the same time, 2 x 20 x FL 20S BLB lamps and FL 20S E-30 lamps manufactured by Toshiba, Japan, at a distance of 10 cm at the same time, 0.8 × 10 ⁷ erg / cm ³ Three consecutive surveys were conducted once daily. The area to be tested was well washed with 70% isopropyl alcohol solution before UV irradiation. After irradiation, the cream sample containing 2% kojic acid was applied evenly twice a day, 1 ml each, and the hydrogel matrix adhesive sheet type cosmetic of Example 2 was cut into a size of 2 × 2 cm ² and cut on the UV irradiation site for 1 day. Twice 3 hours twice.

One month after the test, each test group evaluated how much pigmentation was inhibited by dividing into three steps, and the results are shown in Table 2.

sample Significant effect (persons) Valid (persons) Invalid (persons) Kojic acid 2% cream 3 11 6 Example 2 (2% kojic acid-containing adhesive sheet cosmetics) 7 13 0

From the above Table 2, it can be seen that the positive effect more than effective in the case of using the pressure-sensitive adhesive sheet-type cosmetics of Example 2 than the kojic acid 2% containing cream shows an excellent pigmentation inhibitory effect.

<Test Example 3>

Twenty healthy male and female experimenters fixed the adhesive chic cosmetics prepared by the prescription of each example to the lower arm of the arm for 1 time per day according to the patch test method, and then fixed them with tape, and then after 1 day, 3 days, and 7 days The degree of stimulation was observed according to the determination method of Table 3, and the average value thereof is shown in Table 4.

Judgment number Skin irritation degree 0 No irritation One Minimal irritation 2 Slight irritation (erythema) 3 Severe irritation (erythema, edema) 4 Severe irritation (erythema, edema)

sample Skin irritation degree (%) 1 day later 3 days later 7 days later Example 1 0.8 0.8 0.5 Example 2 0.8 1.0 1.0 Example 3 0.5 0.6 0.8 Example 4 0.4 0.6 0.5 Example 5 0.5 0.8 0.5 Example 6 0.5 0.6 0.3 Example 7 0.3 0.5 0.5 Example 8 0.4 0.8 1.0

From Table 4, after removing the hydrogel matrix adhesive sheet-type cosmetics, the moisture of the lamellar lipid layer, which was present in excess, is naturally volatilized out of the skin to maintain the original moisture content of the skin without leaving any damage to the skin and returning to the original state of the skin. As it restores the original, it can be seen that the skin irritation is low in the formulations of all the examples.

As is apparent from the above, the hydrogel matrix adhesive sheet-type cosmetics of the present invention can improve the stability of the beauty ingredients that can give an effective effect on the skin, and can continuously absorb the beauty ingredients to the skin, skin irritation It can be minimized, it is possible to increase the cosmetic effect than conventional cosmetics. In addition, the cosmetic of the present invention is excellent in adhesion to the skin.

Claims (8)

Consists of an exposed part protective layer, an adhesion part protective layer and at least one hydrogel matrix layer formed between the two layers, wherein the hydrogel matrix layer is 0.01 to 30.0% by weight of a cosmetic ingredient, 0.01 to the total weight of the hydrogel matrix layer. A hydrogel matrix pressure-sensitive adhesive sheet type cosmetic, comprising -70.0 wt% of a water-soluble adhesive, 0.01-5.0 wt% of a crosslinking agent, 0.1-5.0 wt% of an emulsifier, and 0.01-1.0 wt% of a stabilizer. According to claim 1, wherein the cosmetic ingredient is retinol, retinyl palmitate, retinyl acetate, retinoic acid, glycerin, butylene glycol, propylene glycol, hyaluronic acid, sodium chondroitin sulfate, natto gum, skirt mushroom extract, natural amino acids, natural Ceramide, pseudoceramide, caffeine, hamamelis extract, cornus extract, carrot extract, marine collagen, vegetable collagen, vegetable squalene, meadowfoam oil, macadamia oil, olive oil, mineral oil, silicone oil, ester oil, ascor Cosmetics characterized in that at least one member selected from the group consisting of hydrochloric acid and its derivatives added with vinic acid and ascorbic acid palmitate, ascorbic acid phosphate magnesium salt, kojic acid and an alkyl group having 5 to 20 carbon atoms. The method of claim 1, wherein the water-soluble pressure-sensitive adhesive is selected from the group consisting of gelatin, water-soluble polyacrylate, polyvinyl alcohol, xanthan gum, gellan gum, sodium alginate, polyvinylpyrrolidone, polyvinylformamide or carboxymethyl cellulose Cosmetics characterized in that at least one. The cosmetic according to claim 1, wherein the crosslinking agent is at least one selected from the group consisting of glyoxal, zinc salt, aluminum salt, calcium salt or magnesium salt. The cosmetic according to claim 1, wherein the stabilizer is at least one selected from the group consisting of citric acid, succinic acid, oxalic acid or formic acid. The cosmetic according to claim 1, wherein the emulsifier is at least one selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyglyceryl fatty acids or fatty acid sugar esters. The cosmetic according to claim 1, wherein the exposed part protective layer is a woven fabric, a nonwoven fabric or a polymer film. The cosmetic according to claim 1, wherein the adhesion part protective layer is a polypropylene film, polyethylene terephthalate film or polyvinyl chloride film treated with fluorine or silicone.