KR19990087441A - 트레오-메틸페니데이트의 분리방법 - Google Patents
트레오-메틸페니데이트의 분리방법 Download PDFInfo
- Publication number
- KR19990087441A KR19990087441A KR1019980706863A KR19980706863A KR19990087441A KR 19990087441 A KR19990087441 A KR 19990087441A KR 1019980706863 A KR1019980706863 A KR 1019980706863A KR 19980706863 A KR19980706863 A KR 19980706863A KR 19990087441 A KR19990087441 A KR 19990087441A
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- KR
- South Korea
- Prior art keywords
- methylphenidate
- threo
- separation method
- separation
- acid
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Thermal Sciences (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Electrophonic Musical Instruments (AREA)
- Read Only Memory (AREA)
Abstract
본 발명은 (-)-멘톡시아세트산을 사용하여 통상의 염분해를 이용해서 실질적으로 단일한 거울상 이성질체 d-트레오-메틸페니데이트를 제조하는 방법에 관한 것이다.
Description
메틸페니데이트는 처음에 에리트로와 트레오 라세미체의 혼합물로서 제조되었다. 미국특허 제2957880호에는 치료학적 활성이 트레오 부분입체 이성질체에 있음을 밝히는 2개의 라세미 혼합물에 관한 연구가 기재되어 있다.
트레오 메틸페니데이트의 분리는 고가의 분리제인 1,1'-비나프틸-2,2'-디일히드로겐 포스페이트를 사용함으로써 얻어질 수 있으며, 이는 패트릭(Patrick) 등에 의해 처음으로 보고되었으며(The Journal of Pharmacology and Experimental Therapeutics, 241:152-158(1987)) 그 후로 이 분야의 다른 연구가들에 의해서도 사용된 방법이다(예를 들면, 아오야마 등, Journal of Chromatography, 494:420(1989)). 이것은 미국특허 제2957880호에 기재된, 에리트로 메틸페니데이트의 해당 아미드가(즉, R-CON2Me 보다는 R-CONR2), 아미드 가수분해와 벤질 중심에서의 평형보다 먼저 타르타르산과 용해되어 그 결과로 생성된 트레오 산의 에스테르화로 이어지는 방법보다 더 효율적인 방법으로 여겨진다.
개선된 분리 방법은 PCT/GB97/00185에 기재되어 있다. 이러한 분리는 PCT/GB97/00281에 기재된 라세미화와 결합될 수 있다.
본 발명은 부분입체 이성질체 염의 결정화를 통한 트레오 메틸페니데이트의 분리에 관한 것이다.
본 발명은 라세미 트레오 메틸페니데이트가 저가의 (-)-멘톡시아세트산을 사용함으로써 분리될 수 있다는 발견에 기초하고 있다.
본 발명은 통상의 염분해 방법의 기술에서 숙련자들에게 일반적으로 알려져 있는 조건하에서 수행될 수 있다. 예를 들어, 비활성 유기 용매 내에서 트레오 메틸페니데이트 유리 염기와 1몰 당량의 (-)-멘톡시아세트산의 혼합물을 가열하고 이어서 냉각시킨다; 생성된 침전물을 여과하고, 적당한 용매로 세척하고 건조하여 98% ee d-트레오 메틸페니데이트로 농축된 염을 직접 제공한다. 이것은 상기 패트릭 등에 의해 설명된, 1,1'-비나프틸-2,2'-디일히드로겐 포스페이트를 사용한 문헌 방법, 즉 첫번째 결정화로 85 내지 90% ee물질에 해당하는 염을 제공하고, 이 물질의 추가 재결정화가 ee를 95 내지 97%로 상승시키는데 필요한 방법에 대한 굉장한 진보이다. 광학 순도의 후자의 수준은 본 발명에서 전반적으로 더 높은 수득률로 한번의 결정화로 이루어진다. 따라서, 본 발명의 방법은 패트릭 등에 의해 설명된 것보다 더 효율적이며 더 경제적이다.
다음의 실시예는 (-)-멘톡시아세트산을 사용한 트레오 메틸페니데이트의 분리를 보여준다.
dl-트레오 메틸페니데이트(1.0g, 3.7mmol)를 수중에서(20㎖) 현탁하고 가성 용액으로 처리하였다. 유리된 유리 염기를 MTBE로 추출하고(3×25㎖), MgSO4로 건조하고, 경유로 증발시켰다. 이것을 IPA(15㎖)에서 용해하고 60℃로 가열하였다. IPA(5㎖) 내의 (-)-멘톡시아세트산(0.79g, 3.79mmol)을 첨가하였다. 30분 동안 더 가열하고, 혼합물을 10℃까지 점차적으로 냉각시켰다. 생성된 백색의 결정체를 여과하고, 차가운 IPA로 세척하고, 건조하였다(0.85g, 47 중량%, 98% ee d-트레오 메틸페니데이트에 해당, 염분해 후 키랄 HPLC로 결정함).
Claims (1)
- (-)-멘톡시아세트산을 사용하여 통상의 염분해를 이용해서 실질적으로 단일한 거울상 이성질체 d-트레오-메틸페니데이트를 제조하는 방법.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9604943.2 | 1996-03-08 | ||
GBGB9604943.2A GB9604943D0 (en) | 1996-03-08 | 1996-03-08 | Resolution |
US1698696P | 1996-05-07 | 1996-05-07 | |
US60/016,986 | 1996-05-07 | ||
PCT/GB1997/000643 WO1997032851A1 (en) | 1996-03-08 | 1997-03-07 | Resolution of threo-methylphenidate |
Publications (2)
Publication Number | Publication Date |
---|---|
KR19990087441A true KR19990087441A (ko) | 1999-12-27 |
KR100459149B1 KR100459149B1 (ko) | 2005-06-10 |
Family
ID=26308891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR19980706863A KR100459149B1 (ko) | 1996-03-08 | 1997-03-07 | 트레오-메틸페니데이트의분리방법 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0885191B1 (ko) |
JP (1) | JP4138005B2 (ko) |
KR (1) | KR100459149B1 (ko) |
AT (1) | ATE212336T1 (ko) |
AU (1) | AU700836B2 (ko) |
CA (1) | CA2243542C (ko) |
DE (1) | DE69710051T2 (ko) |
DK (1) | DK0885191T3 (ko) |
ES (1) | ES2173422T3 (ko) |
PT (1) | PT885191E (ko) |
WO (1) | WO1997032851A1 (ko) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
US6486177B2 (en) | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
GB9700912D0 (en) | 1997-01-17 | 1997-03-05 | Chiroscience Ltd | Resolution |
US6962997B1 (en) | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
US6100401A (en) * | 1998-04-20 | 2000-08-08 | Novartris Ag | Process for preparing the d-threo isomer of methylphenidate hydrochloride |
US6162919A (en) * | 1998-12-03 | 2000-12-19 | Novartis Ag | Process for preparing the d-threo isomer of methylphenidate hydrochloride |
US7229557B2 (en) | 2004-02-04 | 2007-06-12 | Konec, Inc. | Method to separate stereoisomers |
WO2010128517A1 (en) | 2009-05-07 | 2010-11-11 | Malladi Drugs & Pharmaceuticals Ltd. | Improved process for the preparation of d-threo-ritalinic acid hydrochloride by resolution of dl-threo-ritalinic acid using chiral carboxylic acid |
US9283214B2 (en) | 2011-03-23 | 2016-03-15 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
EP4011364B1 (en) | 2011-03-23 | 2023-12-13 | Ironshore Pharmaceuticals & Development, Inc. | Methods and compositions for treatment of attention deficit disorder |
US8916588B2 (en) | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US10292937B2 (en) | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US8927010B2 (en) | 2011-03-23 | 2015-01-06 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2957880A (en) * | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
US4196303A (en) * | 1978-03-20 | 1980-04-01 | Scm Corporation | d-Isomenthoxyacetic acid |
JPS5538363A (en) * | 1978-09-13 | 1980-03-17 | Yoshitomi Pharmaceut Ind Ltd | Preparation of optically active n-mercaptoacyl-imino acid |
-
1997
- 1997-03-07 DK DK97906283T patent/DK0885191T3/da active
- 1997-03-07 AT AT97906283T patent/ATE212336T1/de not_active IP Right Cessation
- 1997-03-07 EP EP97906283A patent/EP0885191B1/en not_active Expired - Lifetime
- 1997-03-07 PT PT97906283T patent/PT885191E/pt unknown
- 1997-03-07 KR KR19980706863A patent/KR100459149B1/ko not_active IP Right Cessation
- 1997-03-07 CA CA002243542A patent/CA2243542C/en not_active Expired - Fee Related
- 1997-03-07 DE DE69710051T patent/DE69710051T2/de not_active Expired - Fee Related
- 1997-03-07 WO PCT/GB1997/000643 patent/WO1997032851A1/en active IP Right Grant
- 1997-03-07 ES ES97906283T patent/ES2173422T3/es not_active Expired - Lifetime
- 1997-03-07 JP JP53159297A patent/JP4138005B2/ja not_active Expired - Fee Related
- 1997-03-07 AU AU21024/97A patent/AU700836B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0885191B1 (en) | 2002-01-23 |
DE69710051D1 (de) | 2002-03-14 |
AU700836B2 (en) | 1999-01-14 |
CA2243542C (en) | 2003-02-18 |
PT885191E (pt) | 2002-06-28 |
DK0885191T3 (da) | 2002-05-06 |
MX202728B (ko) | 2001-06-29 |
JP2000506162A (ja) | 2000-05-23 |
DE69710051T2 (de) | 2002-08-14 |
ATE212336T1 (de) | 2002-02-15 |
AU2102497A (en) | 1997-09-22 |
EP0885191A1 (en) | 1998-12-23 |
JP4138005B2 (ja) | 2008-08-20 |
WO1997032851A1 (en) | 1997-09-12 |
KR100459149B1 (ko) | 2005-06-10 |
CA2243542A1 (en) | 1997-09-12 |
MX9807266A (ko) | 1999-08-31 |
ES2173422T3 (es) | 2002-10-16 |
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