KR19980068393A - Whitening Soap Composition - Google Patents
Whitening Soap Composition Download PDFInfo
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- KR19980068393A KR19980068393A KR1019970004952A KR19970004952A KR19980068393A KR 19980068393 A KR19980068393 A KR 19980068393A KR 1019970004952 A KR1019970004952 A KR 1019970004952A KR 19970004952 A KR19970004952 A KR 19970004952A KR 19980068393 A KR19980068393 A KR 19980068393A
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- South Korea
- Prior art keywords
- soap
- whitening
- soap composition
- golden extract
- inhibitory effect
- Prior art date
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- 239000000344 soap Substances 0.000 title claims abstract description 37
- 230000002087 whitening effect Effects 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 title claims abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 9
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229940058015 1,3-butylene glycol Drugs 0.000 claims abstract description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 claims abstract description 3
- 239000003960 organic solvent Substances 0.000 claims abstract description 3
- 239000002537 cosmetic Substances 0.000 claims description 3
- 239000003205 fragrance Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 abstract description 22
- 102000003425 Tyrosinase Human genes 0.000 abstract description 13
- 108060008724 Tyrosinase Proteins 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 5
- 230000008099 melanin synthesis Effects 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 description 9
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 8
- 208000012641 Pigmentation disease Diseases 0.000 description 8
- 230000019612 pigmentation Effects 0.000 description 8
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- 239000002585 base Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 239000010931 gold Substances 0.000 description 4
- 229910052737 gold Inorganic materials 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 208000001382 Experimental Melanoma Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- QUAPPCXFYKSDSV-LBPRGKRZSA-N (2s)-5,7-dihydroxy-6-methoxy-2-phenyl-2,3-dihydrochromen-4-one Chemical compound C1([C@H]2OC3=CC(O)=C(C(=C3C(=O)C2)O)OC)=CC=CC=C1 QUAPPCXFYKSDSV-LBPRGKRZSA-N 0.000 description 2
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 235000019482 Palm oil Nutrition 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- -1 alkylbenzene sulfonates Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- RTIXKCRFFJGDFG-UHFFFAOYSA-N chrysin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- LKOJGSWUMISDOF-UHFFFAOYSA-N oroxylin A Chemical compound C=1C(=O)C2=C(O)C(OC)=C(O)C=C2OC=1C1=CC=CC=C1 LKOJGSWUMISDOF-UHFFFAOYSA-N 0.000 description 2
- 239000002540 palm oil Substances 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- YTAQZPGBTPDBPW-UHFFFAOYSA-N 2-phenylchromene-3,4-dione Chemical compound O1C2=CC=CC=C2C(=O)C(=O)C1C1=CC=CC=C1 YTAQZPGBTPDBPW-UHFFFAOYSA-N 0.000 description 1
- NYCXYKOXLNBYID-UHFFFAOYSA-N 5,7-Dihydroxychromone Natural products O1C=CC(=O)C=2C1=CC(O)=CC=2O NYCXYKOXLNBYID-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- FXNFHKRTJBSTCS-UHFFFAOYSA-N Baicalein Natural products C=1C(=O)C=2C(O)=C(O)C(O)=CC=2OC=1C1=CC=CC=C1 FXNFHKRTJBSTCS-UHFFFAOYSA-N 0.000 description 1
- 229930191995 Dihydrooroxylin Natural products 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- BJBKXYIIWYIZCX-UHFFFAOYSA-N Trigraecum Natural products C1=C(O)C(OC)=CC(C(C=2)=O)=C1OC=2C1=CC=CC=C1 BJBKXYIIWYIZCX-UHFFFAOYSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- LNOHXHDWGCMVCO-UHFFFAOYSA-N Wogonoside Natural products C1=C(O)C(C(C=C(O2)C=3C=CC=CC=3)=O)=C2C(OC)=C1OC1OC(C(O)=O)C(O)C(O)C1O LNOHXHDWGCMVCO-UHFFFAOYSA-N 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- UDFLTIRFTXWNJO-UHFFFAOYSA-N baicalein Chemical compound O1C2=CC(=O)C(O)=C(O)C2=C(O)C=C1C1=CC=CC=C1 UDFLTIRFTXWNJO-UHFFFAOYSA-N 0.000 description 1
- 229940015301 baicalein Drugs 0.000 description 1
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 description 1
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 description 1
- 229960003321 baicalin Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229940043370 chrysin Drugs 0.000 description 1
- 235000015838 chrysin Nutrition 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- VJNCICVKUHKIIV-UHFFFAOYSA-N dopachrome Chemical compound O=C1C(=O)C=C2NC(C(=O)O)CC2=C1 VJNCICVKUHKIIV-UHFFFAOYSA-N 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229960004337 hydroquinone Drugs 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- JDWYRSDDJVCWPB-LURJTMIESA-N leucodopachrome Chemical compound OC1=C(O)C=C2N[C@H](C(=O)O)CC2=C1 JDWYRSDDJVCWPB-LURJTMIESA-N 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 230000003061 melanogenesis Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000024181 negative regulation of developmental pigmentation Effects 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 229940079776 sodium cocoyl isethionate Drugs 0.000 description 1
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 230000000007 visual effect Effects 0.000 description 1
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- XLTFNNCXVBYBSX-UHFFFAOYSA-N wogonin Chemical compound COC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=CC=C1 XLTFNNCXVBYBSX-UHFFFAOYSA-N 0.000 description 1
- LNOHXHDWGCMVCO-NTKSAMNMSA-N wogonin 7-O-beta-D-glucuronide Chemical compound C1=C(O)C(C(C=C(O2)C=3C=CC=CC=3)=O)=C2C(OC)=C1O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LNOHXHDWGCMVCO-NTKSAMNMSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
본 발명은 메탄올, 에탄올, 아세톤, 에틸렌글리콜, 프로필렌글리콜, 1,3-부틸렌글리콜 또는 에틸 아세테이트와 같은 유기 용매를 사용하여 추출한 황금 추출물을 0.01중량% 내지 15.0중량%로 함유함을 특징으로 하여 티로시나제의 활성 저해 및 멜라닌 생성억제 효과가 우수한 미백비누 조성물에 관한 것이다.The present invention is characterized by containing from 0.01% to 15.0% by weight of the golden extract extracted using an organic solvent such as methanol, ethanol, acetone, ethylene glycol, propylene glycol, 1,3-butylene glycol or ethyl acetate The present invention relates to a whitening soap composition excellent in inhibiting tyrosinase activity and inhibiting melanin production.
Description
본 발명은 황금 추출물을 함유하는 것을 특징으로 하는 미백비누 조성물에 관한 것으로, 티로시나제의 저해 및 멜라닌 생성 억제효과가 우수하며, 비누 제조시 작업성과 상온 및 40℃에서의 경시 안정성이 우수한 미백비누 조성물에 관한 것이다.The present invention relates to a whitening soap composition comprising a golden extract, excellent in inhibiting tyrosinase and inhibiting melanin production, excellent in workability at the time of soap production and stability at room temperature and 40 ℃ over time to whitening soap composition It is about.
일반적으로, 사람의 피부가 검게 변하는 것은, 피부의 기저층에 존재하는 멜라노사이트(Melanocyte)라는 세포에서 생체 구성 아미노산의 하나인 티로신(Tyrosine)이 티로시나제(Tyrosinase)라는 효소의 작용에 의하여 도파(DOPA, Dihydroxy phenylafanine)가 되고, 다시 티로시나제의 작용에 의하여 도파퀴논(Dopaquinone)이 된다. 계속해서 류코도파크롬(Leucodopachrome)이 생성되고, 다시 도파크롬(Dopachrome)에서 효소 및 비효소적 산화반응에 의하여 유멜라닌(Eumelanin)이라는 흑색의 색소가 형성되어, 이것이 피부를 이루고 있는 세포(Keratinocyte)로 전달되어 피부의 색을 검게 나타내게 된다. 이처럼 티로시나제가 피부 흑색화에 중요한 역할을 하고 있다.In general, the darkening of human skin is caused by the action of an enzyme called tyrosinase, tyrosine, which is one of the biological amino acids in the cells of melanocytes (Melanocyte) in the base layer of the skin. Dihydroxy phenylafanine), and then dopaquinone (Dopaquinone) by the action of tyrosinase. Leucodopachrome is then produced, and a black pigment called eumelanin is formed by enzymatic and non-enzymatic oxidation in Dopachrome, which forms the skin cells (Keratinocyte). The color of skin is blackened. As such, tyrosinase plays an important role in skin blackening.
현재, 피부 흑색화나 기미, 주근깨 등의 방지 및 치료에 티로시나제 저해활성에 효과가 우수하다고 알려진 물질, 즉 코지산, 글루타치온, 히드로퀴논 등이 사용되고 있는데, 이들 물질들은 피부에 대한 안전성 및 제품에 적용시 장기 안정성 면에서 문제점이 있어 사용이 제한되어 오고 있다.Currently, substances known to be excellent in tyrosinase inhibitory activity for the prevention and treatment of skin blackening, blemishes, and freckles, such as kojic acid, glutathione, and hydroquinone, are used. There is a problem in terms of stability has been limited use.
따라서, 본 발명자들은 이러한 문제점을 해결하기 위하여, 천연물 중에서 미백효과가 우수한 물질을 탐색·연구하던 중, 황금 추출물이 티로시나제의 활성을 저해시키고 멜라닌의 생성을 억제하는데 효과가 있는 것을 발견하여 본 발명을 완성하게 되었다.Accordingly, the present inventors, while searching for and researching substances excellent in whitening effect in natural products, in order to solve this problem, the inventors found that the golden extract is effective in inhibiting the activity of tyrosinase and inhibiting the production of melanin. It was completed.
황금은 꿀풀과에 속하는 식물로, 이 식물에 함유되어 있는 성분은 플라보노이드류인 워고닌(Wogonin), 워고노사이드(Wogonoside), 바이칼린(Baicalin), 바이칼레인(Baicalein), 네오바이칼레인(Neobaicalein), 오록실린(Oroxylin) A, 스쿨캅플라본(Skullcapflavone) I, II, 2(S),2,5,6,7-테트라하이드록시 플라보논, 크리신(Chrysin), 디하이드로오록실린(Dihydrooroxylin) A와 유리 아미노산 등이 함유되어 있는 것으로 알려져 있는데, 본 발명에서는 황금을 메탄올, 에탄올, 아세톤, 에틸렌글리콜, 프로필렌글리콜, 1,3-부틸렌글리콜 또는 에틸아세테이트 등과 같은 유기용매를 사용하여 추출하였다.Gold is a plant belonging to the Lamiaceae family, and its components include the flavonoids: Wagonin, Wogonoside, Baicalin, Baicalein, and Neobaiicalein. , Oroxylin A, Schoolcapflavone I, II, 2 (S), 2,5,6,7-tetrahydroxy flavonone, Chrysin, Dihydrooroxylin It is known that A and free amino acids are contained. In the present invention, gold was extracted using an organic solvent such as methanol, ethanol, acetone, ethylene glycol, propylene glycol, 1,3-butylene glycol or ethyl acetate.
따라서, 본 발명을 상세하게 설명하면, 황금 추출물을 함유하는 미백비누 조성물로서, 미백비누를 제조하는데 필요한 베이스는 통상적인 고급 지방산의 알칼리염을 기제로 사용하는 일반 지방산계 비누와 합성 계면활성제를 기제로 사용하는 합성 계면활성제 비누 또는 일반 지방산계 비누와 합성 계면활성제를 주기제 또는 보조기제로 혼합 사용하는 복합비누를 의미하며, 이때 사용되는 지방산계 비누는 탄소수가 8 내지 20인 지방산의 나트륨염 또는 칼륨염이며, 지방산은 야자유, 팜유, 대두유, 피마자유, 올리브유 및 팜핵유 등의 식물유와 우지, 돈지, 어유 등의 동물유로 부터 얻어지며, 단독 또는 혼합하여 사용할 수 있다. 합성 계면활성제 비누의 경우, 소디움 라우릴 설포네이트, 알킬벤젠 설포네이트의 소디움염, 소디움 코코일 이세티오네이트, 아실글루타메이트의 알칼리 금속염 등과 같은 비누에 통상적으로 사용되는 계면활성제를 모두 사용할 수 있다. 또한 복합비누의 경우, 상기의 일반 지방산계 비누 및 합성 계면활성제 비누에 사용되는 원료를 주기제 또는 보조기제로 혼합하여 사용할 수 있다.Therefore, when the present invention is described in detail, as a whitening soap composition containing a golden extract, the base required to prepare the whitening soap is based on general fatty acid soaps and synthetic surfactants using alkali salts of conventional higher fatty acids as a base. Synthetic surfactant soap or composite soap using a general fatty acid soap and a synthetic surfactant as a periodic agent or auxiliary base, used as the soap, the fatty acid soap used is sodium salt or potassium of fatty acids having 8 to 20 carbon atoms It is a salt, fatty acid is obtained from vegetable oils, such as palm oil, palm oil, soybean oil, castor oil, olive oil, and palm kernel oil, and animal oils, such as a tallow, pork, and fish oil, and can be used individually or in mixture. In the case of synthetic surfactant soaps, all surfactants commonly used in soaps such as sodium lauryl sulfonate, sodium salts of alkylbenzene sulfonates, sodium cocoyl isethionate, alkali metal salts of acylglutamate, and the like can be used. In addition, in the case of the complex soap, the raw materials used in the general fatty acid soap and synthetic surfactant soap can be mixed and used as a periodic agent or auxiliary base.
본 발명은 황금 추출물을 함유하는 미백비누 조성물에 관한 것으로, 황금 추출물을 0.01중량% 내지 15.0중량%로 함유함을 특징으로 한다.The present invention relates to a whitening soap composition containing a golden extract, characterized in that it contains 0.01 to 15.0% by weight of the golden extract.
실시예 1 : 티로시나제 활성저해 효과Example 1 Tyrosinase Inhibitory Effect
본 발명에 사용된 황금 추출물에 대한 티로시나제의 활성저해 및 멜라닌 생성 억제 효과를 확인하기 위하여 다음과 같은 실험을 실시하였다.In order to confirm the inhibitory effect of tyrosinase activity and melanin production on the golden extract used in the present invention, the following experiment was conducted.
티로시나제는 버섯류(Mushroom)로 부터 추출한 것으로 시그마(Sigma)사의 것을 사용하였다. 먼저 황산 나트륨 완충액(0.5mol 농도, pH 6.8) 중의 1.5mM 농도의 티로신 용액을 분광광도계(Spectrophotometer, Beckman DU-7500) 큐벳(Cuvette)에 0.1㎖를 넣고, 코펙터(Cofactor)인 도파(DOPA)를 0.6mM의 농도로 만들어 0.01㎖씩 첨가하였다. 여기에 황금 추출물을 각각 0㎖, 0.0003㎖, 0.003㎖, 0.015㎖, 0.03㎖, 0.15㎖, 0.3㎖ 및 0.45㎖씩 첨가하고, 황산 나트륨 완충액을 첨가하여 반응을 진행시켰다. 여기에서 황금 추출물을 넣지 않은 것을 대조군으로 하였다. 반응은 분광광도계를 이용하여 37℃에서 진행시켰으며, 30초마다 385나노미터에서의 흡광도의 변화를 10분간 측정하였다.Tyrosinase was extracted from mushrooms and used by Sigma. First, 0.1 ml of a tyrosine solution at a concentration of 1.5 mM in sodium sulfate buffer (0.5 mol concentration, pH 6.8) was placed in a cuvette of a spectrophotometer (Beckman DU-7500), and a cofactor (DOPA) was used. Was added at a concentration of 0.6 mM in 0.01 ml increments. To this, 0 ml, 0.0003 ml, 0.003 ml, 0.015 ml, 0.03 ml, 0.15 ml, 0.3 ml and 0.45 ml of gold extracts were added, and sodium sulfate buffer was added to proceed with the reaction. No golden extract was added here as a control. The reaction was carried out at 37 ° C. using a spectrophotometer, and the change in absorbance at 385 nanometers was measured every 30 seconds for 10 minutes.
여기서 얻어진 반응속도(시간에 따른 흡광도의 변화율, dA/min)의 차이로부터 다음 식에 의하여 티로시나제의 활성 저해율을 구하였으며 그 결과를 표1에 나타내었다.The inhibition rate of tyrosinase activity was calculated by the following equation from the difference of the reaction rate (the rate of change of absorbance with time, dA / min), and the results are shown in Table 1.
[수학식 1][Equation 1]
[표 1]TABLE 1
황금 추출물의 티로시나제 활성저해 효과Inhibitory Effect of Golden Extract on Tyrosinase Activity
위의 결과에서, 황금 추출물은 티로시나제에 대해 활성저해 효과가 우수함을 알 수 있었다.From the above results, it was found that the golden extract has an excellent inhibitory effect on tyrosinase.
실시예 2 :멜라닌 생성 억제Example 2 Melanin Production Inhibition
상기 황금 추출물을 쥐의 멜라노마 세포(B-16 mouse melanoma cell)의 배양액에 첨가하여 세포 수준에서의 미백효과를 실험하였다. 실시예 1 에서 사용한 농도의 추출물을 첨가한 배지에서 각각 B-16 멜라노마 세포를 3일간 배양한 후, 세포들을 트립신(Trypsin)으로 처리하고 난 후, 배양 용기로부터 떼어내 원심 분리한 후 멜라닌을 추출해내었다.The golden extract was added to the culture solution of mouse melanoma cells (B-16 mouse melanoma cells) to test the whitening effect at the cellular level. After culturing B-16 melanoma cells in the medium to which the extract of the concentration used in Example 1 was added for 3 days, the cells were treated with trypsin, and then separated from the culture vessel, centrifuged, and melanin. Extracted.
여기에 수산화나트륨 용액(1N 농도) 1㎖를 가하여 10분간 끓여 멜라닌을 녹이고, 분광광도계를 이용하여 385나노미터에서 흡광도를 측정하여 생성된 멜라닌의 양을 단위 세포수(106cell) 당 의 흡광도로 나타내는 방법으로 수행하였으며, 아래의 식으로 저해율을 구하여 그 결과를 표2에 나타내었다.Add 1 ml of sodium hydroxide solution (1N concentration), boil for 10 minutes to dissolve melanin, and measure the absorbance at 385 nanometer using a spectrophotometer to measure the amount of melanin produced per unit cell number (10 6 cells). The inhibition rate was calculated by the following equation, and the results are shown in Table 2.
[수학식 2][Equation 2]
[표 2]TABLE 2
황금 추출물의 B-16 멜라노마 세포에 대한 멜라닌 생성 저해효과Inhibitory Effects of Golden Extracts on Melonogenesis in B-16 Melanoma Cells
위의 결과에서, 황금 추출물은 배양된 쥐의 B-16 멜라노마 세포에 대하여 멜라닌 생성 억제 효과가 있음을 알 수 있었다.From the above results, it can be seen that the golden extract has an inhibitory effect on melanogenesis against B-16 melanoma cells in cultured mice.
실시예 3 : 미백비누의 제조 및 색소 침착 저해 실험Example 3 Preparation of Whitening Soap and Pigmentation Inhibition Experiment
황금 추출물을 함유하는 표 3과 같은 조성의 비누를 제조하였다. 이 때, 비누 제조시의 작업성을 성형, 압출 및 형타 과정에서 비누가 기계에 달라붙고 끈적거리는 이형성 상태를 5단계, 즉 매우 우수, 우수, 보통, 불량, 매우 불량으로 구분하여 평가하고 표 3에 나타내었다. 그리고, 각 제조예 및 비교예에서 제조한 비누를 상온 및 40℃의 항온항습기에 3개월 동안 보관시키고, 1주일 간격으로 색상변화를 육안으로 비교, 판정하고 그 결과를 역시 표 3에 나타내었다.Soap of the composition as shown in Table 3 containing the golden extract was prepared. At this time, the workability at the time of soap production was evaluated by classifying the soap release property on the machine during molding, extrusion, and mold-taking process into five stages, namely, very good, excellent, normal, bad, and very poor. Shown in In addition, the soaps prepared in each preparation example and comparative example were stored for 3 months in a constant temperature and humidity chamber at room temperature and 40 ℃, and visually compare and determine the color change at weekly intervals, and the results are also shown in Table 3.
[표 3]TABLE 3
제조예 및 비교예의 미백비누 조성 및 경시 안정성, 작업성Whitening soap composition, stability and workability of the preparation and comparative examples
상기 제조예 및 비교예에서 제조한 미백비누 조성물에 대해 다음과 같은 방법으로 색소침착 저해 효과 실험을 실시하였다.Pigmentation inhibitory effect experiments were carried out on the whitening soap compositions prepared in Preparation Examples and Comparative Examples as follows.
색소 침착 저해 실험Pigmentation inhibition experiment
건강한 남자 10명을 실험 대상자로 선정하여 대상자의 등에 2cm × 2cm 크기의 27 부위 를 선정한 후, 이 부위만 남기고 나머지 부위는 알루미늄 호일로 덮은 후, 일광조사기(OREIL solar Simulator 1000W)를 이용하여 15cm 거리에서 60mJ/cm2의 광량을 조사하였다. 조사전 에탄올 70% 수용액으로 조사부위를 세척하였다. 자외선 조사후 조사 부위에 상기 실시예 및 비교예의 비누 수용액을 도포하고 1일 경과후 색소침착 저해 효과를 확인하였다. 평가방법은 육안 평가로 현저한 저해 효과, 약간의 저해 효과, 저해 효과 없슴의 3단계로 평가하였다. 그 결과는 표4와 같다.Ten healthy men were selected as the test subjects, and 27 areas of 2cm × 2cm size were selected.Then, this area was left and the remaining area was covered with aluminum foil, and then 15cm distance using a solar irradiator (OREIL solar Simulator 1000W) The amount of light at 60 mJ / cm 2 was investigated at. The irradiation site was washed with 70% aqueous ethanol solution before irradiation. After the UV irradiation, the aqueous solution of the soap of Examples and Comparative Examples was applied to the irradiated site, and after 1 day, the inhibition of pigmentation was confirmed. The evaluation method was evaluated by visual evaluation in three stages of significant inhibitory effect, slight inhibitory effect and no inhibitory effect. The results are shown in Table 4.
[표 4]TABLE 4
제조예 및 비교예의 미백비누의 색소침착 저해효과Pigmentation Inhibitory Effects of Whitening Soaps of Preparation and Comparative Examples
위의 결과에서 알 수 있듯이, 황금 추출물은 함유한 실시예의 미백비누가 비교예의 화장비누에 비해 색소침착 저해효과가 우수한 것으로 관찰되었으며, 황금 추출물이 0.01중량% 이하일 경우, 작업성 및 경시안정성은 우수하나 색소침착 저해효과가 나쁘며, 황금 추출물이 15.0 중량% 이상일 경우, 색소침착 저해효과는 우수하나 작업성이 나쁘며, 경시안정성에서 변색이 되는 것을 관찰하였다.As can be seen from the above results, it was observed that the whitening soap of the golden extract contained in the Example was superior to the pigmentation inhibitory effect compared to the cosmetic soap of the comparative example, when the golden extract is 0.01% by weight or less, the workability and time stability are excellent However, the pigmentation inhibitory effect is bad, when the gold extract is more than 15.0% by weight, the pigmentation inhibitory effect is excellent, but the workability is poor, it was observed that discoloration in time stability.
따라서, 본 발명자들은 통상적인 화장비누 베이스와 향료를 함유하는 미백비누 조성물에 대해 황금 추출물을 0.01 중량%에서 15.0 중량% 함유하여 색소침착 저해 효과 및 경시안정성, 작업성이 우수한 미백비누를 발명하게 되었다.Accordingly, the present inventors have invented a whitening soap having excellent pigmentation inhibitory effect, time stability, and workability by containing 0.01 to 15.0 wt% of a golden extract with respect to a whitening soap composition containing a conventional cosmetic soap base and a perfume. .
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| KR100842169B1 (en) * | 2007-05-10 | 2008-06-27 | 대구보건대학산학협력단 | Soap with Perilla and Golden and Sulfur Extracts and Manufacturing Method Thereof |
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