KR102884331B1 - 플라즈미노겐 활성인자 억제제 1 (pai-1) 억제제 및 이의 용도 - Google Patents

플라즈미노겐 활성인자 억제제 1 (pai-1) 억제제 및 이의 용도

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Publication number
KR102884331B1
KR102884331B1 KR1020217010851A KR20217010851A KR102884331B1 KR 102884331 B1 KR102884331 B1 KR 102884331B1 KR 1020217010851 A KR1020217010851 A KR 1020217010851A KR 20217010851 A KR20217010851 A KR 20217010851A KR 102884331 B1 KR102884331 B1 KR 102884331B1
Authority
KR
South Korea
Prior art keywords
delete delete
pai
inhibitor
administration
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
KR1020217010851A
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English (en)
Korean (ko)
Other versions
KR20210057141A (ko
Inventor
조나단 에델슨
Original Assignee
에이리온 테라퓨틱스, 인코포레이티드
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Application filed by 에이리온 테라퓨틱스, 인코포레이티드 filed Critical 에이리온 테라퓨틱스, 인코포레이티드
Priority to KR1020257037244A priority Critical patent/KR20250163416A/ko
Publication of KR20210057141A publication Critical patent/KR20210057141A/ko
Application granted granted Critical
Publication of KR102884331B1 publication Critical patent/KR102884331B1/ko
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dispersion Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Biophysics (AREA)
KR1020217010851A 2018-09-13 2019-09-12 플라즈미노겐 활성인자 억제제 1 (pai-1) 억제제 및 이의 용도 Active KR102884331B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257037244A KR20250163416A (ko) 2018-09-13 2019-09-12 플라즈미노겐 활성인자 억제제 1 (pai-1) 억제제 및 이의 용도

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862731074P 2018-09-13 2018-09-13
US62/731,074 2018-09-13
PCT/US2019/050849 WO2020056160A1 (en) 2018-09-13 2019-09-12 Plasminogen activator inhibitor 1 (pai-1) inhibitors and uses therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257037244A Division KR20250163416A (ko) 2018-09-13 2019-09-12 플라즈미노겐 활성인자 억제제 1 (pai-1) 억제제 및 이의 용도

Publications (2)

Publication Number Publication Date
KR20210057141A KR20210057141A (ko) 2021-05-20
KR102884331B1 true KR102884331B1 (ko) 2025-11-13

Family

ID=68052024

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020217010851A Active KR102884331B1 (ko) 2018-09-13 2019-09-12 플라즈미노겐 활성인자 억제제 1 (pai-1) 억제제 및 이의 용도
KR1020257037244A Pending KR20250163416A (ko) 2018-09-13 2019-09-12 플라즈미노겐 활성인자 억제제 1 (pai-1) 억제제 및 이의 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020257037244A Pending KR20250163416A (ko) 2018-09-13 2019-09-12 플라즈미노겐 활성인자 억제제 1 (pai-1) 억제제 및 이의 용도

Country Status (14)

Country Link
US (1) US20220105068A1 (cg-RX-API-DMAC7.html)
EP (1) EP3849539B1 (cg-RX-API-DMAC7.html)
JP (2) JP2021535925A (cg-RX-API-DMAC7.html)
KR (2) KR102884331B1 (cg-RX-API-DMAC7.html)
CN (2) CN113056268A (cg-RX-API-DMAC7.html)
AU (1) AU2019338459B2 (cg-RX-API-DMAC7.html)
BR (1) BR112021004542A2 (cg-RX-API-DMAC7.html)
CA (1) CA3112558A1 (cg-RX-API-DMAC7.html)
DK (1) DK3849539T3 (cg-RX-API-DMAC7.html)
ES (1) ES3076115T3 (cg-RX-API-DMAC7.html)
IL (1) IL281450A (cg-RX-API-DMAC7.html)
MX (2) MX2021002995A (cg-RX-API-DMAC7.html)
SG (1) SG11202102478SA (cg-RX-API-DMAC7.html)
WO (1) WO2020056160A1 (cg-RX-API-DMAC7.html)

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EP3541358A1 (en) 2016-11-21 2019-09-25 Eirion Therapeutics, Inc. Transdermal delivery of large agents
WO2020056191A1 (en) 2018-09-13 2020-03-19 Eirion Therapeutics, Inc. Uses of plasminogen activator inhibitor 1 (pai-1) inhibitors
CN113155987B (zh) * 2020-12-28 2023-06-06 浙江工商大学 一种微针贴片及其制备方法、应用
IL327134A (en) 2023-09-18 2026-05-01 Eirion Therapeutics Inc Topical formulations and uses of PAI-1 inhibitors
WO2026090113A1 (en) * 2024-10-21 2026-04-30 Versiti Blood Research Institute Foundation, Inc. Modifying transplantable organs ex vivo with rna lipid nanoparticle perfusion
WO2026147911A1 (en) * 2024-12-30 2026-07-09 Eirion Therapeutics, Inc. Topical compositions and regimens

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WO2009123241A1 (ja) * 2008-03-31 2009-10-08 株式会社レナサイエンス プラスミノーゲンアクチベーターインヒビター－１阻害剤

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WO2020056191A1 (en) * 2018-09-13 2020-03-19 Eirion Therapeutics, Inc. Uses of plasminogen activator inhibitor 1 (pai-1) inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040043026A1 (en) * 2002-05-13 2004-03-04 Tai-Lan Tuan Treatment and prevention of abnormal scar formation in keloids and other cutaneous or internal wounds or lesions
WO2009123241A1 (ja) * 2008-03-31 2009-10-08 株式会社レナサイエンス プラスミノーゲンアクチベーターインヒビター－１阻害剤

Also Published As

Publication number Publication date
MX2021002995A (es) 2021-07-15
IL281450A (en) 2021-04-29
US20220105068A1 (en) 2022-04-07
EP3849539A1 (en) 2021-07-21
DK3849539T3 (da) 2026-07-27
ES3076115T3 (en) 2026-08-12
CN113056268A (zh) 2021-06-29
MX2025004193A (es) 2025-05-02
BR112021004542A2 (pt) 2021-06-08
WO2020056160A1 (en) 2020-03-19
KR20210057141A (ko) 2021-05-20
JP2021535925A (ja) 2021-12-23
JP2025011085A (ja) 2025-01-23
SG11202102478SA (en) 2021-04-29
AU2019338459A1 (en) 2021-04-08
CN120983628A (zh) 2025-11-21
KR20250163416A (ko) 2025-11-20
EP3849539B1 (en) 2026-07-01
AU2019338459B2 (en) 2025-07-10
CA3112558A1 (en) 2020-03-19

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