KR102831696B1 - Mhc ii/cii 복합체의 생산 - Google Patents

Mhc ii/cii 복합체의 생산 Download PDF

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KR102831696B1
KR102831696B1 KR1020217043364A KR20217043364A KR102831696B1 KR 102831696 B1 KR102831696 B1 KR 102831696B1 KR 1020217043364 A KR1020217043364 A KR 1020217043364A KR 20217043364 A KR20217043364 A KR 20217043364A KR 102831696 B1 KR102831696 B1 KR 102831696B1
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peptide
cii
mhc
drb1
domain
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KR20220044687A (ko
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슈나이더 나딘 닥터
빙스 슈
실비아 시엔시엘라
홈달 리카드 프로페서
닥터 브루크하르트 하랄트 프로페서
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프라운호퍼 게젤샤프트 쭈르 푀르데룽 데어 안겐반텐 포르슝 에. 베.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/385—Haptens or antigens, bound to carriers
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N9/1051—Hexosyltransferases (2.4.1)
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    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/605—MHC molecules or ligands thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
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  • Biotechnology (AREA)
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KR1020217043364A 2019-08-09 2020-08-07 Mhc ii/cii 복합체의 생산 Active KR102831696B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19191094.2 2019-08-09
EP19191094 2019-08-09
PCT/EP2020/072287 WO2021028350A1 (en) 2019-08-09 2020-08-07 Production of mhc ii/cii complexes

Publications (2)

Publication Number Publication Date
KR20220044687A KR20220044687A (ko) 2022-04-11
KR102831696B1 true KR102831696B1 (ko) 2025-07-07

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US (1) US20220288177A1 (https=)
EP (1) EP4010007B1 (https=)
JP (1) JP7492538B2 (https=)
KR (1) KR102831696B1 (https=)
CN (1) CN114206945B (https=)
CA (1) CA3137810A1 (https=)
ES (1) ES2971719T3 (https=)
PL (1) PL4010007T3 (https=)
WO (1) WO2021028350A1 (https=)

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JP2024537611A (ja) * 2021-08-30 2024-10-16 ジェネンテック， インコーポレイテッド Ｍｈｃｉｉペプチド結合の性質決定のためのアッセイおよび試薬
CN119630690A (zh) 2022-06-03 2025-03-14 豪夫迈·罗氏有限公司 改进的生产细胞
EP4378533A1 (en) 2022-11-29 2024-06-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Patient selection and therapy monitoring for autoimmune disorders
WO2024117967A1 (en) * 2022-12-01 2024-06-06 Dubnovitsky Anatoly Peptide mimics and their use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090227516A1 (en) * 2005-11-17 2009-09-10 Ahlstrom Corporation Compound comprising an autoantigenic peptide and a carrier with a mhc binding motif

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008116468A2 (en) * 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
EP3620465B1 (en) 2007-07-03 2025-02-19 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
US9695410B2 (en) * 2010-07-15 2017-07-04 Technion Research & Development Foundation Limited Isolated high affinity entities with T-cell receptor like specificity towards native complexes of MHC class II and glutamic acid decarboxylase (GAD) autoantigenic peptides
US20130309229A1 (en) 2011-01-28 2013-11-21 The United States Government As Represented By The Department Of Veterans Affairs Recombinant t cell ligands and antibodies that bind b cells for the treatment of autoimmune diseases
WO2017106684A2 (en) * 2015-12-17 2017-06-22 Janssen Biotech, Inc. Antibodies specifically binding hla-dr and their uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090227516A1 (en) * 2005-11-17 2009-09-10 Ahlstrom Corporation Compound comprising an autoantigenic peptide and a carrier with a mhc binding motif

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JP7492538B2 (ja) 2024-05-29
PL4010007T3 (pl) 2024-04-08
ES2971719T3 (es) 2024-06-06
EP4010007B1 (en) 2023-11-15
CN114206945A (zh) 2022-03-18
KR20220044687A (ko) 2022-04-11
EP4010007A1 (en) 2022-06-15
EP4010007C0 (en) 2023-11-15
CN114206945B (zh) 2025-11-04
US20220288177A1 (en) 2022-09-15
JP2022543960A (ja) 2022-10-17
WO2021028350A1 (en) 2021-02-18
CA3137810A1 (en) 2021-02-18

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