KR102654033B1 - 가용성 유니버셜 adcc 증강 합성 융합 유전자 및 펩티드 기술 및 그 용도 - Google Patents
가용성 유니버셜 adcc 증강 합성 융합 유전자 및 펩티드 기술 및 그 용도 Download PDFInfo
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- KR102654033B1 KR102654033B1 KR1020177018958A KR20177018958A KR102654033B1 KR 102654033 B1 KR102654033 B1 KR 102654033B1 KR 1020177018958 A KR1020177018958 A KR 1020177018958A KR 20177018958 A KR20177018958 A KR 20177018958A KR 102654033 B1 KR102654033 B1 KR 102654033B1
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201462089097P | 2014-12-08 | 2014-12-08 | |
| US62/089,097 | 2014-12-08 | ||
| US201562200557P | 2015-08-03 | 2015-08-03 | |
| US62/200,557 | 2015-08-03 | ||
| PCT/US2015/064572 WO2016094456A1 (en) | 2014-12-08 | 2015-12-08 | Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof |
Publications (2)
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| KR20170089003A KR20170089003A (ko) | 2017-08-02 |
| KR102654033B1 true KR102654033B1 (ko) | 2024-04-02 |
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| KR102256152B1 (ko) | 2013-12-12 | 2021-05-27 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | Ｐｄ-1 항체, 이의 항원 결합 단편, 및 이의 의약 용도 |
| RU2725807C2 (ru) | 2014-12-08 | 2020-07-06 | 1Глоуб Байомедикал Ко., Лтд. | Растворимый универсальный усиливающий adcc синтетический слитный ген, пептидная технология и их применение |
| US12269863B2 (en) * | 2018-05-23 | 2025-04-08 | Manysmart Therapeutics, Inc. | Bispecific T cell engager and uses thereof |
| US11434291B2 (en) | 2019-05-14 | 2022-09-06 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| CA3182445A1 (en) | 2020-06-11 | 2021-12-16 | Francisco Leon | Methods and compositions for preventing type 1 diabetes |
| EP4173640A4 (en) * | 2020-06-30 | 2024-08-14 | GAIA BioMedicine Inc. | METHOD FOR STABILIZING THE BINDING OF AN ANTIBODY ON AN NK CELL AND ASSOCIATED USE |
Citations (1)
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| US20120294857A1 (en) | 2010-01-11 | 2012-11-22 | Trustees Of Dartmouth College | Monomeric Bi-Specific Fusion Protein |
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| US5223426A (en) * | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
| IE920716A1 (en) * | 1991-03-07 | 1992-09-09 | Gen Hospital Corp | Redirection of cellular immunity by receptor chimeras |
| DK0826696T3 (da) * | 1996-09-03 | 2002-09-23 | Gsf Forschungszentrum Umwelt | Anvendelse af bi- og trispecifikke antistoffer til inducering af en tumorimmunitet |
| US6455043B1 (en) * | 1998-08-11 | 2002-09-24 | Idec Pharmaceuticals Corporation | Combination therapies for B-cell lymphomas comprising administration of anti-CD20 antibody |
| ATE437891T1 (de) * | 2000-12-07 | 2009-08-15 | Lilly Co Eli | Glp-1 fusionsproteine |
| US7045605B2 (en) * | 2001-06-01 | 2006-05-16 | Cornell Research Foundation, Inc. | Modified antibodies to prostate-specific membrane antigen and uses thereof |
| EP1597350B1 (en) * | 2003-02-27 | 2015-04-08 | Yeda Research And Development Co., Ltd. | Nucleic acid molecules, and compositions containing same useful for treating and detecting influenza virus infection |
| AU2004245038A1 (en) | 2003-06-02 | 2004-12-16 | Alexion Pharmaceuticals, Inc. | De-immunized anti-CD3 antibody |
| DK1673398T3 (da) * | 2003-10-16 | 2011-04-18 | Micromet Ag | Multispecifikke, deimmuniserede CD3-bindere |
| MXPA06009253A (es) * | 2004-02-16 | 2007-04-18 | Micromet Ag | Moleculas de enlace menos inmunogenicas. |
| US20080003225A1 (en) | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
| EP2124994A2 (en) * | 2007-01-23 | 2009-12-02 | Zymogenetics, Inc. | Soluble fc gamma r1a for reducing inflammation |
| US8043621B2 (en) * | 2007-05-10 | 2011-10-25 | Ramot At Tel Aviv University Ltd. | Recombinant fusion protein and polynucleotide construct for immunotoxin production |
| MX2013007392A (es) | 2010-12-22 | 2013-11-01 | Cephalon Australia Pty Ltd | Anticuerpo modificado con vida media mejorada. |
| HK1202587A1 (en) * | 2011-12-15 | 2015-10-02 | The Royal Institution For The Advancement Of Learning/Mcgill University | Soluble igf receptor fc fusion proteins and uses thereof |
| CA2864177C (en) * | 2012-03-01 | 2019-11-26 | Amgen Research (Munich) Gmbh | Prolonged half-life albumin-binding protein fused bispecific antibodies |
| RU2725807C2 (ru) | 2014-12-08 | 2020-07-06 | 1Глоуб Байомедикал Ко., Лтд. | Растворимый универсальный усиливающий adcc синтетический слитный ген, пептидная технология и их применение |
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2015
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2022
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120294857A1 (en) | 2010-01-11 | 2012-11-22 | Trustees Of Dartmouth College | Monomeric Bi-Specific Fusion Protein |
Also Published As
| Publication number | Publication date |
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| NZ732073A (en) | 2019-04-26 |
| RU2017124141A (ru) | 2019-01-10 |
| WO2016094456A1 (en) | 2016-06-16 |
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| EP3230311A1 (en) | 2017-10-18 |
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| AU2015360642B2 (en) | 2019-04-04 |
| JP7095992B2 (ja) | 2022-07-05 |
| EP3230311A4 (en) | 2018-05-30 |
| JP2018502068A (ja) | 2018-01-25 |
| CA2968987C (en) | 2022-05-10 |
| US20220235115A1 (en) | 2022-07-28 |
| JP2021035994A (ja) | 2021-03-04 |
| KR20170089003A (ko) | 2017-08-02 |
| RU2725807C2 (ru) | 2020-07-06 |
| CA2968987A1 (en) | 2016-06-16 |
| CN107108718B (zh) | 2022-07-22 |
| US12247062B2 (en) | 2025-03-11 |
| SG11201704124YA (en) | 2017-06-29 |
| AU2015360642A1 (en) | 2017-06-08 |
| US20170362299A1 (en) | 2017-12-21 |
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