KR102649858B1 - 안질환의 치료를 위한 조성물 및 방법 - Google Patents

안질환의 치료를 위한 조성물 및 방법 Download PDF

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Publication number
KR102649858B1
KR102649858B1 KR1020217039722A KR20217039722A KR102649858B1 KR 102649858 B1 KR102649858 B1 KR 102649858B1 KR 1020217039722 A KR1020217039722 A KR 1020217039722A KR 20217039722 A KR20217039722 A KR 20217039722A KR 102649858 B1 KR102649858 B1 KR 102649858B1
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South Korea
Prior art keywords
ophthalmic composition
antibiotic
hydrogel
thiolated
concentration
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KR1020217039722A
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English (en)
Korean (ko)
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KR20220004753A (ko
Inventor
브렌다 케이. 맨
희경 이
Original Assignee
아이게이트 파마슈티칼스, 인코포레이티드
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Priority to KR1020247008519A priority Critical patent/KR20240038152A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020217039722A 2019-05-03 2020-04-30 안질환의 치료를 위한 조성물 및 방법 Active KR102649858B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247008519A KR20240038152A (ko) 2019-05-03 2020-04-30 안질환의 치료를 위한 조성물 및 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962842995P 2019-05-03 2019-05-03
US62/842,995 2019-05-03
PCT/US2020/030691 WO2020227002A1 (en) 2019-05-03 2020-04-30 Compositions and methods for treatment of ocular diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247008519A Division KR20240038152A (ko) 2019-05-03 2020-04-30 안질환의 치료를 위한 조성물 및 방법

Publications (2)

Publication Number Publication Date
KR20220004753A KR20220004753A (ko) 2022-01-11
KR102649858B1 true KR102649858B1 (ko) 2024-03-20

Family

ID=70861542

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020217039722A Active KR102649858B1 (ko) 2019-05-03 2020-04-30 안질환의 치료를 위한 조성물 및 방법
KR1020247008519A Pending KR20240038152A (ko) 2019-05-03 2020-04-30 안질환의 치료를 위한 조성물 및 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020247008519A Pending KR20240038152A (ko) 2019-05-03 2020-04-30 안질환의 치료를 위한 조성물 및 방법

Country Status (9)

Country Link
US (2) US11376214B2 (https=)
EP (1) EP3962452A1 (https=)
JP (1) JP7334266B2 (https=)
KR (2) KR102649858B1 (https=)
CN (1) CN114025742A (https=)
CA (1) CA3139060A1 (https=)
IL (1) IL287802B2 (https=)
MX (1) MX2021013447A (https=)
WO (1) WO2020227002A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10945858B2 (en) * 2010-09-03 2021-03-16 Globus Medical, Inc. Expandable interspinous process fixation device
GB202008857D0 (en) * 2020-06-11 2020-07-29 Univ Birmingham Fluid gel compositions
GB202008853D0 (en) * 2020-06-11 2020-07-29 Univ Birmingham Fluid gel compositions
CN112587475B (zh) * 2020-12-18 2022-09-13 华熙生物科技股份有限公司 一种载药凝胶及其制备方法
DE102023116924A1 (de) * 2023-06-27 2025-01-02 Carl Zeiss Meditec Ag Kit zur Verwendung in einer Augenoperation und ophthalmische viskoelastische Vorrichtung
WO2025155730A1 (en) * 2024-01-16 2025-07-24 Regents Of The University Of Minnesota Injectable hydrogel for embolization

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE312076T1 (de) * 2001-02-22 2005-12-15 Anika Therapeutics Inc Thiol-modifizierte hyaluronan-derivate
CA2703807C (en) * 2010-05-12 2017-10-24 Molly S. Shoichet Enhanced stability of inverse thermal gelling composite hydrogels
US10137199B2 (en) * 2013-05-14 2018-11-27 Biotime, Inc. Thiolated hyaluronan-based hydrogels cross-linked using oxidized glutathione
US9782345B2 (en) * 2013-10-17 2017-10-10 Jade Therapeutics, Inc. Ocular composition and method
EP3675873A4 (en) * 2017-09-01 2021-06-16 Pmidg, Llc Functionalized and crosslinked polymers
US12029753B2 (en) * 2017-09-19 2024-07-09 The Hong Kong University Of Science And Technology Biocompatible material and methods for making and using thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Shirley Luo et al., Proceedings of the National Conference on Undergraduate Research, University of North Carolina Asheville, 2016.4.7.-9.*

Also Published As

Publication number Publication date
IL287802B1 (en) 2024-05-01
MX2021013447A (es) 2022-02-11
KR20220004753A (ko) 2022-01-11
WO2020227002A1 (en) 2020-11-12
CA3139060A1 (en) 2020-11-12
JP7334266B2 (ja) 2023-08-28
IL287802A (en) 2022-01-01
CN114025742A (zh) 2022-02-08
US20200345634A1 (en) 2020-11-05
US11376214B2 (en) 2022-07-05
KR20240038152A (ko) 2024-03-22
JP2022530837A (ja) 2022-07-01
EP3962452A1 (en) 2022-03-09
IL287802B2 (en) 2024-09-01
US20220287961A1 (en) 2022-09-15

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