KR102636484B1 - Formalin uniform fixation frame for surgical specimens - Google Patents

Abstract

The present invention includes a main body unit formed to have a predetermined internal space, a support part installed in the internal space to support the specimen, and a support part installed in the main body unit to prevent corruption of the specimen. It is characterized by a management unit that supplies the formalin solution to the internal space so that it can be immersed in the solution.
According to the present invention, the temperature and pH of the formalin solution for fixing the specimen collected for biopsy are kept constant, thereby shortening the specimen fixation time and minimizing the impact on protein DNA detection to improve the reliability of biopsy. The purpose is to do it.

Description

Formalin uniform fixation frame for surgical specimens}

The present invention relates to a formalin uniform fixation frame for surgical specimens, and more specifically, to a formalin uniform fixation frame for surgical specimens for fixing the specimen by filling and discharging the formalin solution and allowing the formalin solution to penetrate into the surgical specimen.

In research or medical institutions, biopsy is used as basic data for surgical procedures or as research data by using tissue cells or organs cut from patients as test resection specimens.

The process of making a general test resection specimen involves the following steps: sample collection, fixation, washing, embedding, sectioning, flattening, staining, and mounting. It consists of In this process, the fixation step is performed by exposing the tissue cells or organs collected from the patient to room temperature for a certain period of time to prevent self-decomposition of the tissue cells or organs due to cellular changes inside the human body. This refers to the process of creating and storing an environment similar to that of .

Fixative solutions used to store tissue cells or organs in the fixation stage include acetic alcohol, Bouin's solution, Carnoy solution, formalin paraformaldehyde, or Tsunkel's solution. (Zenker's solution) is mainly used.

Among the above fixatives, formalin is a colorless hazardous chemical with toxicity and is the brand name of an aqueous solution containing 37% (±0.5%) formaldehyde (HCHO). The formalin is known to be about 5 times more toxic than phenol, a toxic aromatic compound, and is mainly used in anesthetics, pesticides, disinfectants, and preservatives. If a person is exposed to formalin for a long time, it can cause central nervous system disorders, shock and coma, and can even lead to death.

Related prior technologies have been proposed to solve this problem.

The proposed prior art sample container with a rupture member (Korean Patent No. 10-2432136) is a container with an open top and a bottom to form a storage space for storing the sample, and is coupled to the open top of the container so that formalin is released. A lid having a sealing material that airtightly seals the stored storage space and the lower part of the storage space, and a pressing film that airtightly seals the upper part of the storage space, and the sealing material is ruptured by pressing the pressing film of the lid into the storage space of the container. It includes a rupturing member capable of being lowered in the storage space to discharge formalin and a filtering member coupled to the lower part of the lid to filter the sealant ruptured by the rupturing member, wherein the rupturing member is adjacent to the bottom of the pressing membrane. A push rod, a plurality of locking pieces radially connected to the push rod, a plurality of connecting rods connected from the locking piece to be close to a lower portion of the inner diameter of the lid, a support ring connecting lower ends of the plurality of connecting rods, and a lower end of the support ring. It includes a blade formed in a ring shape to rupture the edge of the sealing material, the bottom of the container is formed in a hemispherical shape, and an annular support is formed on the inner surface of the bottom.

In the conventionally developed technology, the sample is placed in a storage container containing a formalin solution and stored at room temperature for a certain period of time while the formalin solution permeates the sample. At this time, the PH of the formalin solution changes due to substances released from the sample, and the sample's There are problems that reduce the reliability of biopsy by slowing down the fixation time or affecting protein DNA detection.

Korean Patent No. 10-2432136: Sample container with rupture member

The present invention was proposed to solve the problems of the prior art as described above. By maintaining the temperature and PH of the formalin solution for fixing the specimen at a constant level, the time for specimen fixation is shortened and the reliability of biopsy is improved. The purpose is to do it.

In order to achieve the above object, the formalin uniform fixation frame for surgical specimens according to the present invention includes a main body unit formed to have a predetermined inner space, a support part installed in the inner space, a support part for supporting the specimen, and a support part installed in the main unit to hold the specimen. It is provided with a management unit that supplies the formalin solution to the internal space so that the specimen supported on the support can be submerged in the formalin solution to prevent decay.

The management unit includes a first supply unit connected to the main unit to supply the formalin solution to the internal space, a second supply unit connected to the main unit to supply water to the internal space, and the formalin solution to the internal space. It is provided with a supply control unit that controls the first and second supply units to selectively supply either a solution or water.

The main unit further includes a flow rotation unit installed inside the main unit to force the formalin solution to flow toward the specimen so that the formalin solution flowing into the internal space can easily penetrate into the specimen.

The support portion includes a plurality of support plates stacked on each other so that the sample is seated in the space between the support plates, a coupling portion for coupling the support plates to each other, and a connection portion for attaching the sample to the support plate so that the formalin solution can flow between the support plate and the sample. are provided with a plurality of support protrusions that protrude a predetermined length from one side of the support plate and are spaced apart from each other toward the sample.

The management unit is installed in the main unit, measures the temperature of the formalin solution flowing into the internal space, and maintains the temperature of the formalin solution at a preset reference temperature based on the measured temperature information, A PH measuring unit installed in the main unit to measure the hydrogen ion concentration of the formalin solution flowing into the internal space, a time measuring unit counting the elapsed time during which the formalin solution was supplied to the internal space, and measured by the temperature control unit. A display unit installed in the main unit allows the user to visually identify the temperature information of the formalin solution, the PH concentration of the formalin solution measured by the PH measuring unit, and the elapsed time counted by the time measuring unit. do.

The support plate is formed with a plurality of drainage holes penetrating at positions adjacent to the support protrusions to allow the formalin solution to flow into the specimen between the support plates, and the support portion allows a portion of the tissue fallen from the specimen to pass through the drain holes. A brush is provided including a plurality of protruding protrusions extending from the inner peripheral surface of the drain hole toward the center of the drain hole to prevent it from being lost through the drain hole.

The support portion is provided with a plurality of wires each of which is connected to ends of the support protrusions at both ends of which are adjacent to each other to prevent loss of a portion of the tissue that has fallen off from the specimen.

The main body unit has the inner space inside, a body formed with a through hole communicating with the outside so that the support part can be introduced into the inner space, supports the lower surface of the support part, and extends the inside of the body through the through hole. It extends toward and includes a pivoting rod rotatably installed on the inner wall of the body, and when the support portion is immersed in the formalin solution so that the formalin solution flowing into the internal space penetrates into the specimen, the support portion is tilted at a predetermined angle. It is further provided with a rotating part that rotates the rotating rod so that it rotates back and forth.

It further includes an expansion unit installed in the main body unit to pressurize the formalin solution that expands in the inner space and flows into the inner space.

The expansion unit has a first filling space inside which air is filled, a first expansion tube installed on the inner wall of the inner space, and expands to increase in volume when air is filled, and air is supplied to the first expansion tube. and a first air supply unit that supplies air, and a first air control unit that controls the first air supply unit to supply air to the first expansion tube to expand it when the formalin solution is injected into the internal space.

The internal space of the main unit is divided into a plurality of insertion slots into which the plurality of support parts are respectively inserted, the expansion unit is installed in each of the insertion slots, and a second filling space is filled with air therein. It is provided with a second expansion tube that expands to increase in volume when filled with air, a second air supply unit that supplies air to the second expansion tube, and is installed in the insertion slots to detect the support part inserted into the corresponding insertion slot. When the formalin solution is injected into the internal space based on the detection information provided by the detection sensor, the second expansion tube installed in the insertion slot where the support part is not inserted among the second expansion tubes It is provided with a second air control unit that controls the second air supply unit to inject air into the second expansion tube to enable expansion.

The formalin uniform fixation frame for surgical specimens of the present invention maintains a constant temperature and pH of the formalin solution for fixing specimens collected for biopsy, shortens the specimen fixation time, and minimizes the impact on protein DNA detection. A more accurate biopsy can be performed.

Figure 1 is a perspective view of a first embodiment of a formalin uniform fixation frame for surgical specimens according to the present invention;
Figure 2 is a cross-sectional view of the body unit of Figure 1,
Figure 3 is a perspective view showing a state in which a plurality of body units of Figure 1 are stacked;
Figure 4 is a block diagram showing the management unit of Figure 1,
Figure 5 is a partial cross-sectional view showing a support portion according to a second embodiment of the formalin uniform fixation frame for surgical specimens according to the present invention;
Figure 6 is a partial cross-sectional view showing the support portion according to a third embodiment of the formalin uniform fixation frame for surgical specimens according to the present invention;
Figures 7 and 8 are cross-sectional views showing the rotating portion according to the fourth embodiment of the formalin uniform fixation frame for surgical specimens according to the present invention;
Figures 9 and 10 are cross-sectional views showing the expansion unit according to the fifth embodiment of the formalin uniform fixation frame for surgical specimens according to the present invention;
Figures 11 and 12 are cross-sectional views showing the expansion unit according to the sixth embodiment of the formalin uniform fixation frame for surgical specimens according to the present invention.

Hereinafter, a formalin uniform fixation frame for surgical specimens according to an embodiment of the present invention will be described in detail with reference to the attached drawings. Since the present invention can make various changes and take various forms, specific embodiments will be illustrated in the drawings and described in detail in the text. However, this is not intended to limit the present invention to a specific disclosed form, and should be understood to include all changes, equivalents, and substitutes included in the spirit and technical scope of the present invention. While describing each drawing, similar reference numerals are used for similar components. In the attached drawings, the dimensions of the structures are enlarged from the actual size for clarity of the present invention.

Terms such as first, second, etc. may be used to describe various components, but the components should not be limited by the terms. The above terms are used only for the purpose of distinguishing one component from another. For example, a first component may be named a second component, and similarly, the second component may also be named a first component without departing from the scope of the present invention.

The terms used in this application are only used to describe specific embodiments and are not intended to limit the invention. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this application, terms such as “comprise” or “have” are intended to designate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, but are not intended to indicate the presence of one or more other features. It should be understood that this does not exclude in advance the possibility of the existence or addition of elements, numbers, steps, operations, components, parts, or combinations thereof.

Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as generally understood by a person of ordinary skill in the technical field to which the present invention pertains. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related technology, and should not be interpreted in an ideal or excessively formal sense unless explicitly defined in the present application. No.

1 to 4 show a first embodiment of a formalin uniform fixation frame 10 for surgical specimens according to the present invention.

The formalin uniform fixation frame 10 for a surgical specimen of the present invention includes a main body unit 100 formed with a predetermined internal space 101, a support part 200 installed in the internal space 101, and supporting the specimen 1. ) and the formalin is installed in the main unit 100 into the internal space 101 so that the specimen 1 supported on the support part 200 can be immersed in the formalin solution to prevent corruption of the specimen 1. It is provided with a management unit 300 that supplies a solution.

The specimen (1) is a tissue cell or organ cut from a patient for a biopsy performed at a research institution or medical institution for treatment and diagnosis of the disease, such as determining the malignancy of the tumor, determining the extent of the lesion, and determining whether resection was successful.

At this time, in order to prevent the sample 1 from self-decomposing, the process of infiltrating the sample 1 with a formalin solution to create an environment similar to the environment inside the human body and storing it is called fixation, and is a fixation step. The formalin solution used in is a fixative used to store the specimen (1), and acetic alcohol, Bouin's solution, Carnoy solution, Zenker's solution, etc. can also be applied. You can.

The main body unit 100 has an internal space 101 inside, and a body 110 formed with a through hole 102 communicating with the outside so that the support part 200 can be introduced into the internal space 101. and a door 120 installed on the body 110 to open and close the through hole 102, and a formalin solution so that the formalin solution flowing into the internal space 101 can easily penetrate into the specimen 1. It is provided with a flow rotation unit 130 installed inside the body 1 to force the sample 1 to flow.

The body 110 is formed as a hexahedron with an internal space 101 on the inside, and a through hole 102 communicating with the outside is formed at the front. The body 110 is connected to the first and second supply parts 310 and 320 of the management unit 300, which will be described later, and has an inlet 103 formed on the outer circumferential surface through which the formalin solution or water can be supplied. An outlet 104 communicating with the outside is formed on the outer peripheral surface of the body 110 opposite the inlet 103 to discharge the formalin solution or water flowing into the internal space 101 to the outside. .

In addition, referring to Figure 4, the body 110 is installed on the upper and lower parts of the body 110 so that a plurality of them can be stacked in the vertical direction, and the upper and lower surfaces of the adjacent bodies 110 are magnetically coupled to generate magnetic force. It includes a magnetic coupling part (not shown).

The door 120 is made of a square plate with a larger area than the through hole 102 and is rotatably installed on the front of the body 110 by a rotating member 121 to open and close the through hole 102. Since the pivoting member 121 can be applied to any conventionally developed pivoting technology for pivoting the door 120, additional technologies are omitted. The door 120 is provided with a sealing member (not shown) on the contact surface corresponding to the body 110 so that the internal space 102 can be sealed when the through hole 102 is closed.

The flow rotation unit 130 is connected to a propeller 131 installed on the inner lower surface of the body 110 to flow the formalin solution introduced into the internal space 101 and the propeller 131. It includes a motor 132 that rotates 131. The motor 132 is a DC motor that receives electrical energy and converts it into rotational power.

The flow rotation unit 130 is not limited to the above-described technology, and any conventionally developed fluid flow technology that can flow the formalin solution flowing into the internal space 101 can be applied.

The main unit 100 is configured to filter foreign substances in the formalin solution or water or part of the tissue removed from the specimen 1 on the inner wall of the body 110 adjacent to the inlet 103 to the outlet 104. A filter (not shown) is installed.

The support part 200 is installed in the internal space 101 and is made of a material that is not corroded by the formalin solution to support the specimen 1, and includes a support plate 210, a support protrusion 220, and a coupling part. (230) and a support rod (240).

The support plates 210 are spaced apart from each other in the vertical direction and are rectangular plates with a predetermined thickness that are stacked so that the specimen 1 is seated between the support plates 210. So that the support plate 210 can be inserted into the body 110, the length and width of the support plate 210 correspond to or are smaller than the inner width and insertion depth of the body 110.

The support protrusion 220 separates the sample 1 from the support plate 210 so that the formalin solution can flow between the support plate 210 and the sample 1, so that the formalin solution flows into the support plate ( To enlarge the contact surface between the support plates 210 and the sample 1, a plurality of plates protrude from the upper and lower surfaces of the support plate 210 at a predetermined length, respectively, toward the sample 1.

The shape of the support protrusion 220 is preferably formed to have an oval cross-section as shown in the drawing, but a pillar shape with a circular or polygonal cross-section protruding toward the specimen 1 may also be applied. Alternatively, the support protrusion 220 may have a circular or polygonal cross-section and may be installed on the support plate 210 by extending along the length or width direction of the support plate 210 .

The coupling portion 230 includes a coupling body 231 extending in the height direction of the support plate 210, and a predetermined length extending along the upper surface of the support plate 210 located at the upper portion of the side of the coupling body 231. It is provided with an upper protrusion 232 and a lower protrusion 233 extending a predetermined length along the lower surface of the support plate 210 located below. At this time, the upper protrusion 232 and the lower protrusion 233 are spaced a predetermined distance apart in the vertical direction so that the support plates 210 stacked in the vertical direction are inserted between the upper protrusion 232 and the lower protrusion 233. It is formed to protrude from the outer peripheral surface of the coupling body 231. And the coupling body 231 can press the upper and lower surfaces of the support plate 210, where the upper and lower protrusions 232 and 233 are located at the top and bottom, respectively, so that the support plates 210 can maintain the stacked state. It is preferable that it is made of an elastic body that applies a predetermined elastic force.

A plurality of coupling parts 230 are installed along the outer peripheral surface of the support plate 210, but are not limited to four as shown in the drawing, and the number of installation units can be selectively adjusted by the user.

The support rods 240 support the coupling portion 230, and the support plate 210 slides into the inner space 101 from both inner walls of the body 110. It is in the form of a pillar with a square cross-section that protrudes a predetermined length and extends in the width direction of the body 110. The support rod 240 is formed on both inner walls of the body at a position spaced a predetermined distance upward from the floating rotating part 130. Alternatively, a plurality of the support rods 240 may be installed on the inner wall of the body 110 at a predetermined distance apart from each other in the vertical direction.

The management unit 300 is installed on the body 110 and is installed in the internal space 101 so that the specimen 1 supported on the support part 200 can be immersed in a formalin solution to prevent corruption of the specimen 1. ) by supplying the formalin solution or water to the first supply unit 310, the second supply unit 320, the discharge unit 330, the supply control unit 340, the temperature control unit 350, and the PH measurement unit 360. , a time measuring unit 370, and a display unit 380.

The first supply unit 310 has one end connected to a formalin container (not shown) containing the formalin solution so as to supply the formalin solution to the internal space 101, and the other end connected to the inlet 103. It is installed in the supply pipe 311 and the first supply pipe 311 so that the formalin solution contained in the formalin container can flow into the internal space 101 through the first supply pipe 311. It is provided with a first pump (not shown) that pumps the formalin solution.

The second supply unit 320 has one end connected to a water tank (not shown) containing water so as to supply water to the internal space 101, and the other end is connected to the inlet 103. ) and a second pump (not shown) installed in the second supply pipe 321 to pump water so that water can flow into the internal space 101 through the second supply pipe 321. do. The second supply pipe 321 is not limited to having one end connected to the water tank, and may also be connected to an existing water pipe.

Other ends of the first to second supply pipes 311 and 321 are combined into one pipe and connected to the inlet 103. The first to second supply pipes (311, 321) are hollow pipes, preferably made of polyvinyl chloride (PVC), and hollow pipes with a square, pentagonal, or hexagonal cross section are made of nylon. ), a soft tube made of polyurethane, polyethylene, natural rubber, or synthetic rubber may be applied.

Since the first and second pumps apply water pump technology that moves fluid using mechanical kinetic energy developed in the past, additional descriptions are omitted.

The discharge portion 330 has one end connected to the outlet 104 and the other end passing through the formalin receiving passage so as to discharge the formalin solution or water flowing into the internal space 101 to the outside of the body 110. A discharge pipe 331 connected to a water tank, respectively, and a discharge pipe connected to the discharge pipe 331 to selectively flow the formalin solution and water flowing into the discharge pipe 331 into the formalin receiving tank and the water tank. An open/close valve (not shown) that selectively opens and closes the furnace 331, and a third pump (not shown) installed in the discharge pipe 331 to pressurize the formalin solution and water flowing into the discharge pipe 331. is provided.

The discharge pipe 331 is a hollow pipe, preferably made of polyvinyl chloride (PVC). The hollow pipe with a square, pentagonal, or hexagonal cross-section is made of nylon, polyurethane, A soft tube made of polyethylene, natural rubber, or synthetic rubber may be used.

The open/close valve is a solenoid valve that can control the flow of fluid through remote control.

Since the third pump uses previously developed water pump technology to move fluid using mechanical kinetic energy, additional technology is omitted.

The supply control unit 340 controls the first supply unit 310 and the second supply unit 320 to selectively supply either the formalin solution or water to the internal space 101.

More specifically, the supply control unit 340 controls the first pump to operate and the second pump to not operate when the user inputs an operation signal for supplying the formalin solution to the internal space 101. Thus, the formalin solution is supplied to the internal space 101 through the first supply pipe 311, and the opening/closing valve is controlled to close the discharge pipe 331 to supply the formalin solution to the discharge pipe 331. Make sure this is not released. Subsequently, the supply control unit 340 controls the first pump and the second pump not to operate when the user inputs an operation signal for discharging the formalin solution flowing into the internal space 101, The opening/closing valve is controlled to open the discharge pipe 331 so that the formalin solution is discharged into the discharge pipe 331.

Meanwhile, when the user inputs an operation signal to supply water to the internal space 101, the supply control unit 340 operates the second pump and controls the first pump not to operate, The formalin solution is supplied to the internal space 101 through the first supply pipe 311, and the opening/closing valve is controlled to close the discharge pipe 331 to prevent the formalin solution from being discharged through the discharge pipe 331. Avoid doing so. Subsequently, the supply control unit 340 controls the first pump and the second pump to not operate when the user inputs an operation signal for discharging the water flowing into the internal space 101, and the discharge pipe The on-off valve is controlled to open the discharge pipe 331 so that water is discharged into the furnace 331.

The temperature control unit 350 is installed in the body 110 to measure the temperature of the formalin solution flowing into the internal space 101, and adjusts the temperature of the formalin solution to a preset standard based on the measured temperature information. Maintain at temperature.

The temperature control unit 350 includes a temperature measuring sensor (not shown) that measures the temperature of the formalin solution, and a temperature control unit (not shown) that can maintain the temperature of the formalin solution at 40 degrees, which is a preset reference temperature. Equipped with Since the temperature measurement sensor applies conventionally developed temperature measurement technology, additional technology is omitted. In addition, the temperature control unit can be applied to any cooling or heating technology that can heat or cool the formalin solution and maintain it at the standard temperature, so additional technology is omitted.

The temperature information of the formalin solution measured by the temperature control unit 350 is transmitted to the display unit 380, which will be described later.

The PH measuring unit 360 is installed in the body 110 and measures the hydrogen ion concentration of the formalin solution flowing into the internal space 101. The PH measuring unit 360 is a PH meter that measures the PH concentration of the formalin solution using an electrochemical method, but is not limited to this and is a conventional technology capable of measuring the hydrogen ion concentration of the formalin solution. Anything can be applied. The PH measurement unit 360 transmits the measured PH concentration of the formalin solution to the display unit 380 in order for the user to constantly manage the PH concentration of the formalin solution.

The time measuring unit 370 counts the elapsed time during which the formalin solution is supplied to the internal space 101.

The time measuring unit 370 is connected to the supply control unit 340 at the supply point when the user inputs an operation signal for supplying the formalin solution to the internal space 101. The elapsed time until the time of discharge when the operation signal for discharging the introduced formalin solution is input is counted and transmitted to the display unit 180.

The display unit 370 displays the temperature information of the formalin solution measured by the temperature control unit 350, the hydrogen ion concentration of the formalin solution measured by the PH measurement unit 360, and the time measuring unit 370. It is installed on the front of the door 120 so that the user can visually identify the counted elapsed time. Various conventional display technologies may be applied to the display unit 370, but in this embodiment, it is preferable to use a liquid crystal display (LCD) that is more durable than an LED (Light Emitting Diode) and has a high refresh rate.

The management unit 300 of the formalin uniform fixation frame 10 for surgical specimens of the present invention described above is provided with a PH measuring unit 360 that measures the PH of the formalin solution supplied to the internal space, and the formalin Since the user can consistently manage the PH concentration of the solution, the reliability of the biopsy can be improved.

Meanwhile, Figure 5 shows a second embodiment of a formalin uniform fixation frame 20 for surgical specimens.

The support plate 210 of the formalin uniform fixation frame 20 for a surgical specimen according to the present invention is adjacent to the support protrusion 220 so that the formalin solution can flow into the specimen 1 between the support plates 210. A plurality of drain holes 211 are formed through the position. Although not shown in the drawing, the drain hole 211 may penetrate the outer peripheral surface of the support protrusion 220 in the vertical direction.

The support part 200 of this embodiment further includes a brush 400.

The brush 400 is directed from the inner peripheral surface of the drain hole 211 toward the center of the drain hole 211 to prevent part of the tissue removed from the specimen 1 from being lost through the drain hole 211. It is provided with a brush 400 including a plurality of extended protruding protrusions 410.

Although not shown in the drawing, the brush 400 may be installed on the outer peripheral surface of the support plate 210 adjacent to the drain hole 211 to extend toward the specimen 1.

The formalin uniform fixation frame 20 for a surgical specimen of the present invention described above is provided with a plurality of protruding protrusions 410 extending toward the center of the drainage hole 211, so that a portion of the tissue removed from the specimen is Separation between the support plates 210 can be prevented.

Meanwhile, Figure 6 shows a third embodiment of a formalin uniform fixation frame 30 for surgical specimens.

The support portion 200 of the formalin uniform fixation frame 20 for a surgical specimen according to the present invention is provided at the upper end of the support protrusion 220 with both ends adjacent to each other to prevent loss of a portion of the tissue that has fallen off from the specimen 1. It is provided with a plurality of wires 500 each connected to.

The wire 500 is connected to the upper ends of the adjacent support protrusions 220 so as to cross each other to form a net shape. The wire 500 is preferably screwed to the support protrusion 220, but although not shown in the drawing, it may be coupled to a ring formed on the support protrusion 220 by a knot.

The formalin uniform fixation frame 30 for a surgical specimen of the present invention described above is provided with a plurality of wires 500 each connected to the upper end of the supporting protrusion 220, so that a portion of the tissue removed from the specimen 1 It can be prevented from being separated between the support plates 210.

Meanwhile, Figures 7 and 8 show a fourth embodiment of the formalin uniform fixation frame 40 for surgical specimens.

The main body unit 100 of the formalin uniform fixation frame 40 for surgical specimens according to the present invention supports the lower surface of the coupling portion 230 and extends from the through hole 102 in the width direction of the body 110. It extends and further includes a pivoting rod 140 rotatably installed on the inner wall of the body 110.

The rotating rod 140 is a square plate installed at a predetermined distance upward from the floating rotating part 130, with both ends supported by the rotating part 600, which will be described later.

The formalin uniform fixation frame 40 for a surgical specimen according to the present invention corresponds to a case where the support part 200 is immersed in the formalin solution so that the formalin solution flowing into the internal space 101 penetrates into the specimen 1. The support unit 200 is further provided with a rotation unit 600 that rotates the rotation rod 140 so that the support unit 200 rotates back and forth at a predetermined angle.

The pivoting portion 600 includes first and second actuators 610 and 620 rotatably installed on both ends of the pivoting rod 140 to drive the support portion 200 in the up and down direction, and the pivoting rod. Both ends of 140 include a drive control unit (not shown) that controls the first and second actuators 601 and 620 to alternately drive in the up and down directions.

The first and second actuators 610 and 620 are preferably installed to support the front and rear sides of the support part 200, respectively. However, although not shown in the drawing, they may be installed to support the width direction of the support part 200. Also, multiple installations may be performed by the user. In addition, since the first and second actuators 610 and 620 are based on conventionally developed inflow cylinder technology, additional description will be omitted.

The formalin uniform fixation frame 40 for a surgical specimen of the present invention described above is provided with a rotating part 600 that rotates the support part 200 back and forth at a predetermined angle, so that the formalin solution is inside the specimen 1. The penetration time required for penetration can be shortened.

Meanwhile, Figures 9 and 10 show a fifth embodiment of the formalin uniform fixation frame 50 for surgical specimens.

The formalin uniform fixation frame 50 for a surgical specimen according to the present invention is an expansion unit installed in the main body unit 100 to expand in the internal space 101 and pressurize the formalin solution flowing into the internal space 101. (700) is further provided.

The expansion unit 700 is provided with a first filling space 701 in which air is filled, and is installed on the inner wall of the inner space 101. When air is filled, the expansion unit 700 increases in volume and ends at the support portion ( A first expansion tube 710 that expands toward 200, a first air supply unit 720 that supplies air to the first expansion tube 710, and the first expansion butt 710 expands to form the support portion. A touch sensor 730 installed on the first expansion tube 710 to detect contact with (200), and a touch received by the touch sensor 730 when the formalin solution is injected into the internal space 101. Based on the information, the first air supply unit 720 is controlled to supply air to the first expansion tube 710 so that the first expansion tube 710 expands to the point where it contacts the support part 200. 1 Equipped with an air control unit (not shown).

The first expansion tube 710 is installed at the top of the inner wall of the body 110 opposite the flow rotation unit 130. The first expansion tube 710 is provided with a first filling space 701 inside which air is filled, and when air is filled into the first filling space 701, the outer peripheral surface is in contact with the inner wall of the body 110. It expands toward the support portion 200 in a close contact state. That is, the first expansion tube 710 is expanded by air filled in the first filling space 701 to flow the formalin solution contained in the internal space 101 toward the support part 200.

The first expansion tube 710 supports both ends of the first expansion tube 710 so that it is fixed to the inner top of the body 110 in a state where it is not filled with air, and is attached to the inner top of the body 110. It is provided with a first tube fixing member 711 fixedly installed. In addition, the tube fixing member 221 penetrates the tube fixing member 711 to allow air supplied from the first air supply unit 720 to flow into the inside of the first expansion tube 710, thereby forming the filling space ( A first air hole 702 in communication with 701 is formed.

The first air supply unit 720 supplies air to the first expansion tube 710, and has one end connected to the first air hole 702 to supply air to the first filling space 701. It includes an air supply pipe 721 and a first compressor (not shown) formed at the other end of the first air supply pipe 721 to supply air to the first air supply pipe 721. In addition, the first air supply unit 720 is installed in the first air supply pipe 721, and air is injected into the first filling space 701, and the first air supply unit 720 is supplied from the first expansion tube 710. It is further provided with a first check valve 722 that prevents air from being discharged into the air supply pipe 721.

The contact sensor 730 is installed at the end of the first expansion tube 710 and detects contact between the first expansion tube 710 and the support portion 300. Since the contact sensor 730 can use previously developed sensor technology that can detect contact, additional technology is omitted.

When the formalin solution is injected into the internal space 101, the first air control unit (not shown) causes the first expansion tube 710 to operate the support portion ( The first air supply unit 720 is controlled to supply air to the first expansion tube 710 so that it expands until it contacts the 200. That is, the first air control unit expands the first expansion tube 710 to pressurize the formalin solution flowing into the internal space 101 and flow the first air supply unit 720 toward the support unit 200. ) is controlled.

The formalin uniform fixation frame 50 for a surgical specimen of the present invention described above is provided with the first expansion tube that expands to the point of contact with the support part 200, so that the formalin solution flowing into the internal space 101 Since this pressure can be applied, the penetration time required for the formalin solution to penetrate into the specimen 1 can be shortened.

Meanwhile, Figures 11 and 12 show a sixth embodiment of the formalin uniform fixation frame 60 for surgical specimens.

The main body unit 100 of the formalin uniform fixation frame 60 for surgical specimens according to the present invention has the internal space 101 with a plurality of insertion slots 105 into which the plurality of support parts 200 are respectively inserted. It is divided.

The insertion slot 105 divides the internal space 101 by a plurality of support rods 240 installed at a predetermined distance from each other in the vertical direction on the inner wall of the body 110.

The expansion unit 800 of the formalin uniform fixation frame 60 for surgical specimens according to the present invention is installed in each of the insertion slots 105, and a second filling space 801 filled with air is provided therein. , installed in the second expansion tube 810, which expands to increase in volume when filled with air, the second air supply unit 820 that supplies air to the second expansion tube 810, and the insertion slots 105. When the formalin solution is injected into the internal space 101, based on the detection sensor 830 that detects the support part 200 inserted into the insertion slot 105 and the detection information provided by the detection sensor 830, , to the corresponding second expansion tube 810 so that the second expansion tube 810 installed in the insertion slot 105 where the support part 200 is not inserted among the second expansion tubes 810 can be expanded. It is provided with a second air control unit (not shown) that controls the second air supply unit 820 to inject air.

The second expansion tube 810 is installed on the inner wall of the body 110 opposite the insertion slot 105. The second expansion tube 810 is provided with a second filling space 801 inside which air is filled, and when air is filled into the second filling space 801, the outer circumferential surface is moved to the body along the insertion slot 105. It expands in the width direction of (110). That is, the second expansion tube 810 is filled with air in the second filling space 801 so as to fill the corresponding insertion slot 105 where the support part 200 inserted into the internal space 101 is not inserted. expands by

The second expansion tube 810 supports both ends of the second expansion tube 810 so that it is fixed to the inner wall of the body 110 corresponding to the insertion slot 105 in a state in which the second expansion tube 810 is not filled with air. , and a second tube fixing member 811 is fixedly installed on the inner wall of the body 110. In addition, the tube fixing member 811 penetrates the tube fixing member 811 so that the air supplied from the second air supply unit 820 flows into the inside of the second expansion tube 710, thereby forming the filling space ( A second air hole 802 in communication with 801 is formed.

The second air supply unit 820 supplies air to the second expansion tube 810, and has one end connected to the second air hole 802 to supply air to the second filling space 701. It includes 2 air supply pipes 821 and a second compressor (not shown) formed at the other end of the second air supply pipe 821 to supply air to the second air supply pipe 821. In addition, the second air supply unit 820 is installed in the second air supply pipe 821, and air is injected into the second filling space 801, and the second air supply is supplied from the second expansion tube 810. It is further provided with a second check valve 822 that prevents air from being discharged into the air supply pipe 821.

The detection sensor 830 is installed at the end of the second expansion tube 810 and detects contact between the second expansion tube 810 and the inner wall surface of the body 110. Since the detection sensor 830 can apply conventionally developed contact sensor technology that can detect contact, additional technology is omitted.

When the formalin solution is injected into the internal space 101, the second air control unit (not shown) causes the second expansion tube 810 to expand the body ( The second air supply unit 820 is controlled to supply air to the second expansion tube 810 so that it expands to the point of contact with the inner wall surface of the tube 110. That is, the second air control unit expands the second expansion tube 810 to fill the insertion slot 105 where the support part 200 inserted into the internal space 101 is not inserted. Controls the supply unit 820.

The formalin uniform fixation frame 60 for the surgical specimen of the present invention described above includes the second expansion butt 810 that can fill the corresponding insertion slot 105 where the support part 200 inserted into the internal space 101 is not inserted. ), it is possible to save the formalin solution flowing into the internal space 101.

The description of the presented embodiments is provided to enable any person skilled in the art to use or practice the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be applied to other embodiments without departing from the scope of the invention. Thus, the present invention is not limited to the embodiments presented herein, but is to be construed in the broadest scope consistent with the principles and novel features presented herein.

1: Sample
10 to 60: Formalin uniform fixation frame for surgical specimens
100: main unit 110: body
120: door 130: floating rotating part
200: support 210: support plate
220: support protrusion 230: coupling portion
240: support rod
300: management unit 310; first supply department
320: second supply unit 330; discharge part
340: supply control unit 350: temperature control unit
360: PH measurement unit 370: Time measurement unit
380: display unit
400: Brush 500: Wire
600: rotating part 610: first actuator
620: second actuator
700, 800: Expansion unit
710: first expansion tube 720: first air supply unit
730: Contact sensor
810: first expansion tube 820: second air supply unit
830: Detection sensor

Claims (11)

A main body unit formed to have a predetermined internal space;
A support part installed in the internal space and supporting the sample; and
A management unit installed in the main unit and supplying the formalin solution to the internal space so that the specimen supported on the support part can be submerged in the formalin solution to prevent corruption of the specimen,
The main unit is
A body having the internal space inside and a through hole communicating with the outside so that the support part can be introduced into the internal space; and
Supporting the lower surface of the support part, extending from the through hole toward the inside of the body, and comprising a rotating rod rotatably installed on the inner wall of the body,
Characterized by a rotating part that rotates the rotating rod so that the supporting part reciprocates at a predetermined angle when the supporting part is immersed in the formalin solution so that the formalin solution flowing into the internal space penetrates into the specimen.
Formalin uniform fixation frame for surgical specimens.
According to paragraph 1,
The management unit is
A first supply unit connected to the main unit to supply the formalin solution to the internal space,
A second supply unit connected to the main unit to supply water to the internal space, and
Characterized in that it has a supply control unit that controls the first and second supply units to selectively supply either the formalin solution or water to the internal space,
Formalin uniform fixation frame for surgical specimens.
According to paragraph 1,
The main unit is
Characterized by further comprising a flow rotation unit installed inside the main unit to force the formalin solution to flow toward the specimen so that the formalin solution flowing into the internal space can easily penetrate into the specimen.
Formalin uniform fixation frame for surgical specimens.
According to paragraph 1,
The support part
A plurality of support plates stacked on each other so that the sample is seated in the space between them,
A coupling part that connects the support plates to each other, and
Characterized in that the sample is spaced apart from the support plate so that the formalin solution can flow between the support plate and the sample, and a plurality of support protrusions protruding a predetermined length are provided on one side of the support plate toward the sample. ,
Formalin uniform fixation frame for surgical specimens.
According to paragraph 1,
The management unit is
A temperature controller installed in the main unit to measure the temperature of the formalin solution flowing into the internal space and maintain the temperature of the formalin solution at a preset reference temperature based on the measured temperature information,
A PH measuring unit installed in the main unit and measuring the hydrogen ion concentration of the formalin solution flowing into the internal space,
A time measuring unit that counts the elapsed time during which the formalin solution was supplied to the internal space, and
The temperature information of the formalin solution measured by the temperature control unit, the PH concentration of the formalin solution measured by the PH measuring unit, and the elapsed time counted by the time measuring unit are provided to the main unit so that the user can visually identify them. Characterized by having a display unit installed,
Formalin uniform fixation frame for surgical specimens.
According to paragraph 4,
The support plate is
A plurality of drainage holes are formed through a position adjacent to the support protrusion so that the formalin solution can flow into the specimen between the support plates,
The support part
Characterized in that it is provided with a brush including a plurality of protruding protrusions extending from the inner peripheral surface of the drain hole toward the center of the drain hole to prevent part of the tissue removed from the specimen from being lost through the drain hole.
Formalin uniform fixation frame for surgical specimens.
According to paragraph 4,
The support part
Characterized in that a plurality of wires are each connected to ends of the supporting protrusions at both ends adjacent to each other to prevent loss of a portion of the tissue that has fallen off from the specimen.
Formalin uniform fixation frame for surgical specimens.
delete A main body unit formed to have a predetermined internal space;
A support part installed in the internal space and supporting the sample; and
a management unit installed in the main unit and supplying the formalin solution to the internal space so that the specimen supported on the support portion can be submerged in the formalin solution to prevent corruption of the specimen;
characterized by comprising an expansion unit installed in the main body unit to pressurize the formalin solution that expands in the internal space and flows into the internal space.
Formalin uniform fixation frame for surgical specimens.
According to clause 9,
The expansion unit is
A first expansion tube is provided with a first filling space inside which air is filled, is installed on the inner wall of the inner space, and expands to increase its volume when filled with air;
A first air supply unit that supplies air to the first expansion tube, and
Characterized by a first air control unit that controls the first air supply unit to supply air to the first expansion tube to expand it when the formalin solution is injected into the internal space.
Formalin uniform fixation frame for surgical specimens.
According to clause 9,
The main unit is
The internal space is divided into a plurality of insertion slots into which the plurality of support parts are respectively inserted,
The expansion unit is
A second expansion tube is installed in each of the insertion slots, has a second filling space filled with air, and expands to increase its volume when filled with air;
A second air supply unit that supplies air to the second expansion tube,
A detection sensor installed in the insertion slots to detect the support part inserted into the insertion slot, and
Based on the detection information provided by the detection sensor, when the formalin solution is injected into the internal space, the second expansion tube installed in the insertion slot where the support part among the second expansion tubes is not inserted can be expanded. Characterized by a second air control unit that controls the second air supply unit to inject air into the second expansion tube.
Formalin uniform fixation frame for surgical specimens.

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