CN220380810U - Blood sample adding device capable of being plugged and cell enrichment and dyeing integrated equipment - Google Patents
Blood sample adding device capable of being plugged and cell enrichment and dyeing integrated equipment Download PDFInfo
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- CN220380810U CN220380810U CN202321918528.8U CN202321918528U CN220380810U CN 220380810 U CN220380810 U CN 220380810U CN 202321918528 U CN202321918528 U CN 202321918528U CN 220380810 U CN220380810 U CN 220380810U
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Abstract
The utility model discloses a blood sample adding device capable of plugging and a cell enrichment dyeing integrated device, which comprises a blood feeding component used for feeding a blood sample, a pressure generator used for providing positive pressure for the blood feeding component, and a blood discharging tube communicated with the blood feeding component and used for discharging blood outwards, wherein a plugging structure is arranged on the blood discharging tube, the plugging structure conducts the blood discharging tube when the blood sample enters the blood discharging tube, and cuts off the blood discharging tube after the blood sample in the blood discharging tube is discharged. In the utility model, the pressure generator is used for introducing positive pressure into the blood feeding component to discharge the blood sample in the blood feeding component through the blood discharge tube, the blocking structure cuts off the blood discharge tube after the blood sample in the blood feeding component is discharged, and the positive pressure in the blood feeding component cannot flow to the outside through the blood discharge tube, so that the pressure leakage after the blood sample in the blood feeding component is discharged is effectively avoided.
Description
Technical Field
The utility model belongs to the field of medical detection equipment, and particularly relates to a plugging blood sample adding device and cell enrichment and dyeing integrated equipment.
Background
Currently, in the fields of clinical detection and biomedical technology, detection of components such as cells and biological macromolecules in biological fluids (e.g., human blood) is increasingly emphasized and developed. The biological fluid is detected, the trauma to a patient can be avoided, the test sample is convenient to obtain, and the method can be widely applied to immunological research detection, gene research detection or microorganism detection, and even applied to biological chips and organoid research and development.
Before detecting the components such as cells and biomacromolecules in the biological fluid, the collected biological fluid needs to be removed from the storage container, and the target cells or biomacromolecules are filtered and stained for further detection.
Taking the example of detecting circulating tumor cells, circulating tumor cells are produced in the peripheral blood of a patient before a solid tumor is formed in the patient. Early screening and diagnosis of malignant tumors can be accomplished by detecting circulating tumor cells. The method can complete tumor diagnosis before solid tumor formation, has less damage to patients, has good effects on prognosis of malignant tumor, disease progress monitoring, recurrence prediction, tiny focus monitoring after malignant tumor operation and design and treatment effect monitoring of targeted drug treatment, and is widely used.
Since the circulating tumor cells are present in the peripheral blood in small amounts, it is necessary to enrich the circulating tumor cells in the blood sample drawn from the patient for further detection.
In enriching for circulating tumor cells, a patient's blood sample needs to be transferred from a blood collection tube to a specific device for filtration and staining. It is common practice to pressurize a blood collection tube using a pressure generating device, to express a blood sample from the blood collection tube out of the blood collection tube, and to expel the blood sample through a blood evacuation tube.
When the positive pressure is used for discharging the blood sample, once the blood sample is discharged, the blood discharge tube is communicated with the inside and the outside, so that pressure leakage is caused, the positive pressure generated by the pressure generator is wasted, and the operation of adding the blood sample is influenced.
In view of this, the present utility model has been made.
Disclosure of Invention
The utility model provides a plugging blood sample adding device and cell enrichment and dyeing integrated equipment, and aims to solve the problem of pressure leakage after blood sample is discharged.
In order to solve the technical problems, the utility model adopts the basic conception of the technical scheme that:
a closable blood sample application device comprising a blood supply assembly for supplying a blood sample and a pressure generator for providing a positive pressure to the blood supply assembly,
the blood discharging device is characterized by further comprising a blood discharging tube which is communicated with the blood feeding assembly and used for discharging blood outwards, wherein a blocking structure is arranged on the blood discharging tube, the blocking structure conducts the blood discharging tube when blood samples enter the blood discharging tube, and the blood discharging tube is cut off after the blood samples in the blood discharging tube are discharged.
Further, the plugging structure comprises a pressure stabilizing bin communicated with the blood drainage tube and a floating block arranged in the pressure stabilizing bin, wherein the floating block can shade a liquid outlet of the pressure stabilizing bin.
Further, the liquid outlet of the voltage stabilizing bin is arranged at the bottom of the voltage stabilizing bin.
Further, the floating block is spherical, and the liquid outlet of the pressure stabilizing bin is circular with the diameter smaller than that of the floating block.
Further, the lower part of the pressure stabilizing bin is provided with a funnel-shaped structure with the diameter gradually reduced from top to bottom, and a liquid outlet of the pressure stabilizing bin is positioned at the bottom of the funnel-shaped structure.
Further, the blood sample adding device comprises a plurality of blood feeding components and blood discharging pipes correspondingly communicated with the blood feeding components, each blood feeding component is communicated with the same pressure generator, and each blood discharging pipe is provided with a plugging structure.
Further, the blood sample adding device further comprises a sampling fixing table, a plurality of clamping positions are arranged on the sampling fixing table, and the voltage stabilizing bin can be matched and clamped with the clamping positions.
Further, the blood feeding assembly comprises a blood collection tube for containing a blood sample, an intermediate sealing tube, a blood suction tube communicated with the intermediate sealing tube and the blood collection tube, and a blood discharge tube communicated with the inside and the outside of the intermediate sealing tube, wherein the pressure generator is communicated with the intermediate sealing tube and used for pressurizing and/or depressurizing the intermediate sealing tube, and the blood discharge tube is used for discharging the blood sample in the intermediate sealing tube outwards.
Further, the blood feeding assembly comprises a sealed blood collection tube with a sealing cover, the pressure generator is communicated with the sealed blood collection tube, the sealed blood collection tube is provided with a blood discharge tube communicated with the outside, and the pressure generator is used for pressurizing the sealed blood collection tube.
A cell enrichment staining integrated device comprising any one of the above-described sealable blood sample adding devices.
By adopting the technical scheme, compared with the prior art, the utility model has the following beneficial effects.
1. The pressure stabilizing bin with the plugging structure is arranged on the blood discharging tube, so that the blood discharging tube can be blocked after the blood sample in the blood feeding assembly is discharged, and the pressure leakage provided by the pressure generator is prevented, so that the normal operation of the blood feeding device is influenced.
2. The same pressure generator is used for introducing positive pressure into the blood feeding components, the pressure stabilizing bin on the blood discharging tube corresponding to the blood feeding component for discharging the blood sample is blocked by the blocking structure, the positive pressure introduced into the blood feeding component by the pressure generator cannot leak from the pressure stabilizing bin, the positive pressure in other blood feeding components is ensured to be sufficient, and the blood sample can be discharged normally.
The following describes the embodiments of the present utility model in further detail with reference to the accompanying drawings.
Drawings
The accompanying drawings, which are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate embodiments of the utility model and together with the description serve to explain the utility model. It is evident that the drawings in the following description are only examples, from which other drawings can be obtained by a person skilled in the art without the inventive effort. In the drawings:
FIG. 1 is a front view of a closable blood sample application device of the present utility model;
FIG. 2 is a schematic illustration of another occluded blood sample application device of the present utility model;
FIG. 3 is a front view of another occluded blood sample application device of the present utility model;
FIG. 4 is a top view of another occluded blood sample application device of the present utility model;
fig. 5 is an enlarged view of the utility model at a in fig. 1, 3.
In the figure: 410. sealing the blood collection tube; 411. a blood collection tube; 412. sealing cover; 415. drawing blood vessels; 421. a pressure generator; 422. a voltage divider; 430. discharging blood vessels; 431. an intermediate seal tube; 432. a middle tube; 433. an intermediate sealing cover; 437. a pressure stabilizing bin; 438. a floating block; 439. a funnel-shaped structure; 440. a pressurizing tube; 450. a sampling fixing table; 457. and positioning holes.
It should be noted that these drawings and the written description are not intended to limit the scope of the inventive concept in any way, but to illustrate the inventive concept to those skilled in the art by referring to the specific embodiments.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions in the embodiments will be clearly and completely described with reference to the accompanying drawings in the embodiments of the present utility model, and the following embodiments are used to illustrate the present utility model, but are not intended to limit the scope of the present utility model.
In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
The utility model provides a plugging blood sample adding device and a cell enrichment and staining integrated device as shown in figures 1 to 5, wherein the cell enrichment and staining refers to filtering cells to be detected from a blood sample to be detected, and staining the cells by using a reagent so as to facilitate observation and detection.
The blood sample adding device pumps the blood sample in the blood sampling tube 411 from the blood sampling tube 411 to a specified position for filtration and staining.
The present utility model provides a closable blood sample applying device, as shown in fig. 1 to 5, comprising a blood feeding assembly for feeding a blood sample, which is in communication with a blood discharge vessel 430 for discharging blood out of the blood feeding assembly, and a pressure generator 421 for providing a positive pressure to the blood feeding assembly.
The blood feeding assembly is internally provided with a blood sample collected from the patient, the blood feeding assembly is communicated with the pressure generator 421, the pressure generator 421 is used for introducing positive pressure into the blood feeding assembly, and the blood sample in the blood feeding assembly is extruded out through the blood discharge tube 430.
The blood drainage tube 430 is provided with a blocking structure, the blocking structure conducts the blood drainage tube 430 when blood sample enters the blood drainage tube 430, and cuts off the blood drainage tube 430 after the blood sample in the blood drainage tube 430 is discharged.
In the present utility model, when there is a blood sample in the blood drain 430, the occlusion structure conducts the blood drain 430, and the pressure generator 421 applies positive pressure to the blood feeding set to drain the blood sample from the blood feeding set through the blood drain 430. When the blood sample in the blood feeding assembly is discharged, no blood sample exists in the blood discharging tube 430, the blocking structure cuts off the blood discharging tube 430, and the circulation in the blood discharging tube 430 is blocked, so that the positive pressure fed into the blood feeding assembly by the pressure generator 421 cannot circulate to the outside through the blood discharging tube 430, and the pressure leakage is avoided.
As an embodiment of the present utility model, the plugging structure includes a pressure stabilizing bin 437 in communication with the drainage tube 430 and a floating block 438 disposed in the pressure stabilizing bin 437, where the floating block 438 can block the liquid outlet of the pressure stabilizing bin 437.
The central axis of the pressure stabilizing chamber 437 extends in the same direction as the blood drain tube 430. The radius of the pressure stabilizing bin 437 is greater than the radius of the drainage tube 430.
The pressure stabilizing bin 437 comprises a liquid inlet end for inflow of blood supply samples and a liquid outlet end for outflow of the blood supply samples. The pressure stabilizing bin 437 can be arranged in the middle of the blood discharging tube 430, and the liquid inlet end and the liquid outlet end of the pressure stabilizing bin 437 are respectively communicated with the blood discharging tubes 430 at two sides of the pressure stabilizing bin 437; the pressure stabilizing chamber 437 may be provided at an end of the blood discharge tube 430 remote from the blood feeding unit, and only the liquid inlet end of the pressure stabilizing chamber 437 may be connected to the blood discharge tube 430.
In this embodiment, when there is a blood sample in the blood feeding assembly, the floating block 438 in the pressure stabilizing chamber 437 is floated to avoid the liquid outlet of the pressure stabilizing chamber 437, and the pressure generator 421 introduces positive pressure into the blood feeding assembly to discharge the blood sample from the blood feeding assembly via the blood discharge tube 430. When the blood sample in the blood feeding component is discharged, the floating block 438 in the pressure stabilizing bin 437 seals the liquid outlet of the pressure stabilizing bin 437, and the circulation in the blood discharging tube 430 is blocked, so that the positive pressure fed into the blood feeding component by the pressure generator 421 cannot circulate to the outside through the blood discharging tube 430, and the pressure leakage is avoided.
Further, as shown in fig. 1 to 5, the pressure generator 421 is a peristaltic pump capable of providing positive pressure and negative pressure, and the peristaltic pump includes a driver, a pump head and a pressurizing tube 440, wherein the driver drives the pump head to squeeze the pressurizing tube 440, and a unidirectional air flow is formed in the pressurizing tube 440, and flows into the blood feeding assembly through the pressurizing tube 440, so as to pressurize the blood feeding assembly. During this pressurization, the gas flowing into the blood feeding set passes through only the pressurization tube 440 and does not contact the internal structure of the peristaltic pump itself, without fear of contaminating the blood sample with the peristaltic pump.
Further, as shown in fig. 5, the density of the floating block 438 is smaller than that of the blood sample, when the blood sample exists in the pressure stabilizing bin 437, the floating block 438 floats along with the blood sample, and a gap exists between the floating block 438 and the liquid outlet of the pressure stabilizing bin 437; when no blood sample exists in the pressure stabilizing bin 437, the floating block 438 sinks to seal the liquid outlet of the pressure stabilizing bin 437.
In this technical scheme, the floating block 438 floats with the increase or decrease of the blood sample in the pressure stabilizing bin 437, when the blood sample enters the pressure stabilizing bin 437, the floating block 438 floats by the buoyancy of the blood sample, a gap is formed between the floating block 438 and the liquid outlet of the pressure stabilizing bin 437, and the blood sample is discharged from the gap. When the blood sample in the blood feeding assembly is discharged, the blood sample in the pressure stabilizing bin 437 flows completely, the floating block 438 falls under the action of self gravity, the liquid outlet of the pressure stabilizing bin 437 is pressed and covered, a sealing effect is formed on the pressure stabilizing bin 437, and positive-pressure resistance air flow passes through the pressure stabilizing bin, so that positive-pressure leakage is avoided.
The floating block 438 is matched with the pressure stabilizing bin 437 to serve as a plugging structure, the lifting of the floating block 438 is controlled by the buoyancy of the blood sample, manual intervention is not needed, and the automation of the on-off control of the blood drainage tube 430 is realized.
As an embodiment of the present utility model, as shown in fig. 5, the liquid outlet of the pressure stabilizing bin 437 is disposed at the bottom of the pressure stabilizing bin 437.
Further, a liquid outlet of the pressure stabilizing bin 437 is disposed at a center position of the bottom of the pressure stabilizing bin 437.
In this embodiment, the liquid outlet of the pressure stabilizing bin 437 is arranged at the bottom of the pressure stabilizing bin 437, and the blood sample entering the pressure stabilizing bin 437 can be completely discharged from the liquid outlet of the pressure stabilizing bin 437 at the bottom under the action of gravity, so that the residual blood sample is avoided, and the quantity of the collected cells in the filtering and collecting device can be increased.
As an implementation manner of this embodiment, as shown in fig. 5, the floating block 438 is spherical, the liquid outlet of the pressure stabilizing bin 437 is circular with a diameter smaller than that of the floating block 438, the pressure stabilizing bin 437 is barrel-shaped, and the height of the pressure stabilizing bin 437 along the central axis direction is larger than that of the floating block 438, and the floating block 438 has a space floating along the central axis direction in the pressure stabilizing bin 437.
Further, the pressure stabilizing bin 437 is a cylindrical pressure stabilizing bin 437, the diameter of the axial section of the pressure stabilizing bin 437 is larger than that of the floating block 438, and the floating block 438 can move in the pressure stabilizing bin 437 without being limited by the inner side wall of the pressure stabilizing bin 437.
In this embodiment, when the blood sample is discharged, the spherical floating block 438 falls back to the bottom of the pressure stabilizing chamber 437, and the outer wall of the spherical floating block is abutted against the liquid outlet of the pressure stabilizing chamber 437, and forms a seal under the action of the gravity of the floating block 438. Further, the spherical floating blocks 438 are identical in shape in all directions, so that the phenomenon that the spherical floating blocks are not tightly sealed with a liquid outlet of the pressure stabilizing bin 437 due to movement and rolling in the pressure stabilizing bin 437 is avoided, and the reliability of automatic opening and closing of the pressure stabilizing bin 437 is improved.
As another implementation manner of this embodiment, as shown in fig. 5, the lower portion of the pressure stabilizing bin 437 has a funnel-shaped structure 439 with a gradually decreasing diameter from top to bottom, and the liquid outlet of the pressure stabilizing bin 437 is located at the bottom of the funnel-shaped structure 439.
Further, the upper edge of the funnel-shaped structure 439 is connected with the inner wall of the cylindrical pressure stabilizing bin 437, that is, the maximum diameter of the funnel-shaped structure 439 is the same as the diameter of the pressure stabilizing bin 437, and the minimum diameter of the funnel-shaped structure 439 is the same as the diameter of the liquid outlet of the pressure stabilizing bin 437.
In this embodiment, when the floating block 438 is sunk, the floating block 438 will sink to the liquid outlet position of the pressure stabilizing bin 437 along the peripheral inner wall of the funnel-shaped structure 439, so that the phenomenon that the liquid outlet of the pressure stabilizing bin 437 cannot be completely blocked and positive pressure is leaked due to deviation of the falling point when the floating block 438 is sunk is avoided.
As another embodiment of the present utility model, as shown in fig. 1 to 4, the blood feeding device includes a plurality of blood feeding units, and a blood discharge tube 430 correspondingly connected to the blood feeding units, wherein each blood feeding unit is connected to the same pressure generator 421, and a blocking structure is disposed on each blood discharge tube 430.
Further, the blood sample adding device further comprises a voltage divider 422, the voltage divider 422 comprises an air inlet end and an air outlet end, the air outlet end comprises a plurality of air outlets, and each air outlet is respectively communicated with the air inlet end. Each blood feeding component is communicated with the air outlets in a one-to-one correspondence manner.
In this embodiment, the same pressure generator 421 provides positive pressure to several blood feeding units simultaneously through the pressure divider 422, so that when blood samples are pressed out from the blood discharge tubes 430 corresponding to the blood feeding units, the volumes of the blood samples in the blood feeding units may not be the same, and the viscosity of the blood samples may also be different, resulting in a sequential difference in the time for discharging the blood samples in the blood feeding units. The pressure stabilizing bin 437 with the plugging structure can automatically plug the blood drainage tube 430 corresponding to the blood feeding assembly which is drained completely, and prevent the blood drainage tube 430 from leaking positive pressure introduced by the air pressure generator.
As another embodiment of the present utility model, as shown in fig. 1 to 4, the blood sample adding device further includes a sampling fixing table 450, a plurality of positioning holes 457 are provided on the sampling fixing table 450, and the pressure stabilizing bin 437 can be clamped with the positioning holes 457 in a matching manner.
Further, the positioning hole 457 is a through hole with a large top and a small bottom formed on the sampling fixing table 450, and the pressure stabilizing bin 437 is inserted into the through hole with a large top and a small bottom from top to bottom.
Further, the pressure stabilizing chamber 437 is disposed at the liquid outlet of the blood drain tube 430, only the liquid inlet end of the pressure stabilizing chamber 437 is connected to the liquid outlet of the blood drain tube 430, and the blood sample is directly discharged from the liquid outlet end of the pressure stabilizing chamber 437 to a designated position.
Alternatively, the pressure stabilizing chamber 437 may be disposed in the middle of the blood discharging tube 430, and the blood discharging tube 430 connected to the liquid outlet end of the pressure stabilizing chamber 437 is shorter, so that the accurate discharge of the blood sample to the designated position via the sampling fixing table 450 is not affected.
In this embodiment, the pressure stabilizing cabin 437 is used as a structure for being engaged with the sampling fixing table 450, so that the blood drainage tube 430 can be effectively fixed, and a special engaging structure is not required to be arranged on the blood drainage tube 430, so that the structure of the blood drainage tube 430 is simpler.
As another embodiment of the present utility model, as shown in fig. 1 and 2, the blood feeding unit includes a blood sampling tube 411 for containing a blood sample, an intermediate sealing tube 431, a blood sampling tube 415 communicating the intermediate sealing tube 431 with the blood sampling tube 411, a blood discharge tube 430 communicating the inside and outside of the intermediate sealing tube 431, the pressure generator 421 communicating with the intermediate sealing tube 431 and for pressurizing and/or depressurizing the intermediate sealing tube 431, and the blood discharge tube 430 for discharging the blood sample in the intermediate sealing tube 431 to the outside.
The intermediate sealing tube 431 is used for temporarily storing the blood sample drawn from the blood sampling tube 411. The middle sealing pipe 431 is sealed and isolated from the outside to form an airtight structure.
Further, the middle sealing pipe 431 includes an intermediate pipe 432 and an intermediate sealing cover 433 that are disposed in an open manner, and the intermediate sealing cover 433 may have a cover structure that can wrap the pipe orifice of the intermediate pipe 432 and the outer wall adjacent to the pipe orifice, or may have a plug structure that can be plugged into the pipe orifice and tightly abutted against the inner wall of the pipe orifice.
Preferably, the middle sealing cover 433 has a cover structure.
In this embodiment, the pressure generator 421 firstly pumps air from the middle sealing tube 431 to reduce pressure, so that the air pressure in the middle sealing tube 431 is lower than the atmospheric pressure, and the blood sample in the opened blood sampling tube 411 is pressed into the middle sealing tube 431 by the atmospheric pressure through the blood sampling tube 415. After the blood drawing is completed, the pressure generator 421 introduces positive pressure into the middle sealing tube 431, so that the air pressure in the middle sealing tube 431 is greater than the atmospheric pressure, and the blood sample in the middle sealing tube 431 is extruded out through the blood discharge tube 430.
The negative pressure is used for pumping the blood sample in the blood sampling tube 411 into the middle sealing tube 431, and compared with the design that the positive pressure is used for extruding the blood sample from the blood sampling tube 411, the blood sampling tube 411 is arranged in the design in an open way, and the sealing is not required to be covered, so that the use procedure of a user is simplified, and the work load is reduced. In this process, the pressure generator 421 only provides the air flow having the positive pressure and the negative pressure, the blood sample itself does not flow through the pressure generator 421, the risk of the blood sample contaminating the pressure generator 421 is avoided, and the pressure generator 421 does not need to be cleaned even after repeated use, so that maintenance is facilitated.
Further, the blood adding device comprises a plurality of middle sealing pipes 431, a blood drawing pipe 415 and a blood drawing pipe 411 which are communicated with each middle sealing pipe 431, and the plurality of rows of blood vessels 430 are also communicated with the plurality of middle sealing pipes 431 in a one-to-one correspondence manner.
Further, the pressure generator 421 communicates with each intermediate sealed tube 431 via a pressure divider 422, providing positive and/or negative pressure into each intermediate sealed tube 431.
When a pressure generator 421 is used to provide positive pressure to each middle sealing tube 431 to discharge blood samples, when a certain middle sealing tube 431 is used to discharge blood samples first, the blocking structure in the pressure stabilizing bin 437 corresponding to the middle sealing tube 431 can block the pressure stabilizing bin 437, so that the positive pressure introduced into the pressure generator 421 cannot leak, the condition that the positive pressure in other middle sealing tubes 431 is sufficient is ensured, and the blood samples can be effectively pressed into the blood discharge tube 430 to be discharged.
As another embodiment of the present utility model, as shown in fig. 3 and 4, the blood feeding unit includes a sealed blood collection tube 410 having a sealing cover, the pressure generator 421 is in communication with the sealed blood collection tube 410, the sealed blood collection tube 410 is provided with a blood discharge tube 430 in communication with the outside, and the pressure generator 421 is used to pressurize the sealed blood collection tube 410.
The pressure generator 421 is communicated with the sealed blood collection tube 410 through a pressurizing tube 440.
The sealed blood collection tube 410 comprises a blood collection tube 411 and a sealing cover 412, wherein the sealing cover 412 can adopt a cover type structure capable of wrapping a tube orifice and an outer tube wall adjacent to the tube orifice, and can also adopt a plug type structure plugged into the tube orifice and tightly abutted against an inner tube wall adjacent to the tube orifice. After the blood sample is collected, the blood sample is temporarily stored in the blood collection tube 411, and at this time, the sealing cover 412 is matched with the blood collection tube 411, so that the blood collection tube 411 and the outside form a sealed blood collection tube 410 with an airtight structure.
In this embodiment, a pressure generator 421 is simultaneously connected to a plurality of the sealed blood collection tubes 410, and the positive pressure generated by the pressure generator 421 is introduced into the sealed blood collection tubes 410 to press the blood sample in the sealed blood collection tubes 410 out of the blood discharge tube 430. The scheme does not need to separately arrange the pressure generators 421 for each sealed blood collection tube 410, so that the number of the pressure generators 421 is reduced, the cost is reduced, the structure of the blood sample adding device is simplified, and the difficulty of maintenance is reduced.
As shown in fig. 1 and 2, the blood sample adding device includes a plurality of sealed blood collection tubes 410 and a blood discharge tube 430 respectively connected to each sealed blood collection tube 410, and the pressure generator 421 is connected to each sealed blood collection tube 410 via a pressure divider 422 and introduces positive pressure into the pressure generator. Each row of blood vessels 430 is provided with a pressure stabilizing bin 437 with a plugging structure.
In this embodiment, the pressure generator 421 supplies positive pressure to each sealed blood collection tube 410 to push the blood sample therein into the blood discharge tube 430 to be discharged. The blood samples in each sealed blood collection tube 410 are different in volume and viscosity, and the blood samples in part of the sealed blood collection tubes 410 are discharged first. The pressure stabilizing bin 437 on the corresponding blood discharge tube 430 of the sealed blood collection tube 410 is blocked by the blocking structure, so that the positive pressure leakage of the pressure generator 421 into the sealed blood collection tube 410 is avoided, and the normal discharge of blood samples in other sealed blood collection tubes 410 is ensured.
The utility model also provides a cell enrichment and dyeing integrated device which comprises the plugging blood sample adding device and a device for filtering and dyeing. The blood sample adding device and the device for filtering and dyeing are all arranged on the same fixed frame to form an integrated device for enriching and dyeing cells.
In the present utility model, the blocking structure in the surge tank 437 can block the drainage tube 430 when the blood sample in the blood feeding set is drained, preventing positive pressure leakage in the blood feeding set.
Further, the closable blood adding component of the integrated device comprises a plurality of blood sending components, a pressure stabilizing bin 437 with a plugging structure is arranged on a blood discharging tube 430 communicated with each blood sending component, and one pressure generator 421 is simultaneously communicated with each blood sending component.
When the blood sample in the blood feeding component is discharged first, the pressure stabilizing bin 437 on the blood discharging tube 430 communicated with the blood feeding component is blocked by the blocking structure, so that the pressure in the blood feeding component is prevented from leaking, and the normal discharge of the blood sample in other blood feeding components is ensured.
The foregoing description is only a preferred embodiment of the present utility model, and the present utility model is not limited to the above-mentioned embodiment, but is not limited to the above-mentioned embodiment, and any simple modification, equivalent change and modification made by the technical matter of the present utility model can be further combined or replaced by the equivalent embodiment without departing from the scope of the technical solution of the present utility model.
Claims (10)
1. A closable blood sample application device comprising a blood supply assembly for supplying a blood sample and a pressure generator (421) for providing a positive pressure to the blood supply assembly, characterized in that:
the blood collection device further comprises a blood discharge vessel (430) which is communicated with the blood feeding assembly and used for discharging blood outwards, wherein a blocking structure is arranged on the blood discharge vessel (430), the blocking structure conducts the blood discharge vessel (430) when blood samples enter the blood discharge vessel (430), and the blood discharge vessel (430) is cut off after the blood samples in the blood discharge vessel (430) are discharged.
2. A device for adding a blood sample, which is capable of being plugged as claimed in claim 1, wherein: the plugging structure comprises a pressure stabilizing bin (437) communicated with the blood drainage tube (430) and a floating block (438) arranged in the pressure stabilizing bin (437), wherein the floating block (438) can plug a liquid outlet of the pressure stabilizing bin (437).
3. A device for adding a blood sample, which is capable of being plugged as claimed in claim 2, wherein: the liquid outlet of the pressure stabilizing bin (437) is arranged at the bottom of the pressure stabilizing bin (437).
4. A device for adding a blood sample, which is capable of being occluded according to claim 3, wherein: the floating blocks (438) are spherical, and the liquid outlet of the pressure stabilizing bin (437) is circular with the diameter smaller than that of the floating blocks (438).
5. The closable blood sample addition device of claim 4 wherein: the lower part of the pressure stabilizing bin (437) is provided with a funnel-shaped structure (439) with the diameter gradually reduced from top to bottom, and a liquid outlet of the pressure stabilizing bin (437) is positioned at the bottom of the funnel-shaped structure (439).
6. A device for adding a blood sample, which is capable of being plugged according to any one of claims 1-5, wherein: the blood sample adding device comprises a plurality of blood feeding components and a blood discharging tube (430) correspondingly communicated with the blood feeding components, each blood feeding component is communicated with the same pressure generator (421), and each blood discharging tube (430) is provided with a plugging structure.
7. A device for adding a blood sample, which is capable of being plugged according to any one of claims 2-5, wherein: the blood sample adding device further comprises a sampling fixing table (450), a plurality of locating holes (457) are formed in the sampling fixing table (450), and the pressure stabilizing bin (437) can be clamped with the locating holes (457) in a matching mode.
8. A device for adding a blood sample, which is capable of being plugged according to any one of claims 1-5, wherein:
the blood feeding assembly comprises a blood sampling tube (411) for containing a blood sample, an intermediate sealing tube (431), a blood drawing tube (415) communicated with the intermediate sealing tube (431) and the blood sampling tube (411), the intermediate sealing tube (431) is communicated with the blood discharging tube (430), the pressure generator (421) is communicated with the intermediate sealing tube (431) and used for pressurizing and/or depressurizing the intermediate sealing tube (431), and the blood discharging tube (430) is used for discharging the blood sample in the intermediate sealing tube (431) outwards.
9. A device for adding a blood sample, which is capable of being plugged according to any one of claims 1-5, wherein:
the blood feeding assembly comprises a sealed blood collection tube (410) with a sealing cover, the pressure generator (421) is communicated with the sealed blood collection tube (410), the sealed blood collection tube (410) is communicated with the blood discharge tube (430), and the pressure generator (421) is used for pressurizing the sealed blood collection tube (410).
10. The utility model provides a cell enrichment dyeing integration equipment which characterized in that: a blood sample adding device comprising a occluder as claimed in any one of claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321918528.8U CN220380810U (en) | 2023-07-20 | 2023-07-20 | Blood sample adding device capable of being plugged and cell enrichment and dyeing integrated equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321918528.8U CN220380810U (en) | 2023-07-20 | 2023-07-20 | Blood sample adding device capable of being plugged and cell enrichment and dyeing integrated equipment |
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| Publication Number | Publication Date |
|---|---|
| CN220380810U true CN220380810U (en) | 2024-01-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321918528.8U Active CN220380810U (en) | 2023-07-20 | 2023-07-20 | Blood sample adding device capable of being plugged and cell enrichment and dyeing integrated equipment |
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| Country | Link |
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| CN (1) | CN220380810U (en) |
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2023
- 2023-07-20 CN CN202321918528.8U patent/CN220380810U/en active Active
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