KR102621217B1 - Compositon for improving joint function - Google Patents

Abstract

The present invention provides turmeric extract; and magnesium, amino acids, or combinations thereof; and provides a composition for improving joint function containing as an active ingredient.

Description

Composition for improving joint function {COMPOSITON FOR IMPROVING JOINT FUNCTION}

The present invention relates to a composition for improving joint function.

This application claims the benefit of the filing date of Korean Patent Application No. 10-2015-0067697 filed with the Korean Intellectual Property Office on May 14, 2015, the entire contents of which are incorporated into this specification.

Joints are parts where two or more bones come into contact with each other and are connected, and they exist throughout the human body, including knees, elbows, waist, and shoulders. Joints contain synovial fluid that acts as a lubricant between two bones, and the joints are connected by muscles and ligaments between the bones, and can bend due to the traction force of these muscles and ligaments. Since the range of movement direction and size of a joint is set to a certain range, if bending or rotation exceeding this range occurs, or if bending or rotation exceeding a certain level occurs repeatedly, a disorder occurs in the joint.

In the case of substances known to be effective in arthritis and joint function, they only provide the effect of improving joint inflammation and relieving pain through this, but there is no known substance that improves joint function by strengthening joint muscles.
There are many prior arts regarding compositions for improving joint function containing the turmeric extract, minerals, or amino acids of the present invention (Patent Document 1-2).

Japanese Patent Publication No. 2014-507437 (2014.03.27.) US Patent Publication US8962045 (2015.02.24.)

The present invention seeks to provide a composition that not only improves joint inflammation and suppresses pain, but also improves the function of joint muscles.

The present invention provides turmeric extract; and magnesium, amino acids, or combinations thereof; and provides a composition for improving joint function containing as an active ingredient.

The present invention provides a composition that not only improves joint inflammation and relieves joint pain, but also improves joint function by strengthening the joint muscles surrounding the joint. Specifically, it provides a composition that improves joint function by reducing the weight load on the joint when the joint moves. By reducing it, physical damage to cartilage can be prevented, excessive rotation of the joint can be prevented, and joint stability can be maintained.

Hereinafter, the composition for improving joint function according to the present invention will be described in detail.

In this specification, turmeric ( Curcuma longa L. rhizome ) refers to a perennial plant of the ginger family.

The composition according to the present invention can improve joint inflammation and relieve joint pain by containing turmeric extract as an active ingredient.

In one embodiment of the present invention, the content of the turmeric extract is 10% by weight to 80% by weight based on the total weight of the composition.

In one embodiment of the present invention, magnesium is contained as an active ingredient along with the turmeric extract, which not only improves joint inflammation and relieves joint pain, but also strengthens joint muscles.

In one embodiment of the present invention, the content of magnesium is 2% by weight to 20% by weight based on the total weight of the composition.

In one embodiment of the present invention, amino acids are contained as active ingredients along with the turmeric extract, which not only improves joint inflammation and relieves joint pain, but also strengthens joint muscles.

In one embodiment of the present invention, the content of the amino acid is 0.1% by weight to 10% by weight based on the total weight of the composition.

In one embodiment of the present invention, the amino acid is one or more selected from the group consisting of valine, leucine, isoleucine, glutamine, arginine, methionine, threonine, lysine, phenylalanine, and tryptophan.

In one embodiment of the present invention, the amino acid is at least one selected from the group consisting of valine, leucine, isoleucine, glutamine, and arginine.

In one embodiment of the present invention, the amino acid is one or more selected from the group consisting of methionine, threonine, lysine, phenylalanine, and tryptophan.

In one embodiment of the present invention, ginger extract, willow extract, or a mixture thereof is further included as an auxiliary ingredient.

In one embodiment of the present invention, the content of the auxiliary ingredient is 3% to 90% by weight based on the total weight of the composition.

In one embodiment of the present invention, magnesium and amino acids are contained as active ingredients along with the turmeric extract, which not only improves joint inflammation and relieves joint pain, but also has a synergistic effect of strengthening joint muscles. can be further improved.

In one embodiment of the present invention, the composition is for suppressing joint pain or strengthening joint muscles. The composition can not only improve joint inflammation and relieve joint pain, but also strengthen joint muscles.

In one embodiment of the present invention, the composition is for strengthening knee joint function. The composition according to the present invention is particularly effective in strengthening the function of the knee joint, which is one of the joints that bear the most load in the human body, by strengthening the joint muscles.

The composition according to the present invention may be a topical skin preparation, but is preferably an oral composition.

In one embodiment of the present invention, the composition further includes an excipient and a coating agent. The excipient and coating agent may be any one or more selected from the group consisting of crystalline cellulose, dibasic calcium phosphate, carboxymethyl cellulose, silicon dioxide, magnesium stearate, and hypromellose.

In one embodiment of the present invention, the composition may further include appropriate carriers, excipients, and diluents commonly used in the preparation of the composition.

In one embodiment of the present invention, the composition may have various oral dosage forms that are convenient for ingestion, for example, tablets, capsules, soft capsules, pills, granules, drinks, etc.

In one embodiment of the present invention, the composition is a health food composition.

In one embodiment of the present invention, the preferred intake amount of the composition varies depending on the body's health status, body weight, degree of disease, etc., but can be appropriately selected by a person skilled in the art.

Hereinafter, a method for improving joint function, a method for strengthening joint muscles, a method for suppressing joint pain, and a method for strengthening knee joint function according to the present invention will be described in detail.

The present invention provides a method for improving joint function comprising the step of orally administering the composition for improving joint function.

The present invention provides a method of strengthening joint muscles comprising the step of orally administering the composition for improving joint function.

The present invention provides a method for suppressing joint pain comprising the step of orally administering the composition for improving joint function.

The present invention provides a method for enhancing joint function comprising the step of orally administering the composition for improving joint function.

The present invention provides a method for enhancing knee joint function comprising the step of orally administering the composition for improving joint function.

In the method for improving joint function, the method for strengthening joint muscles, the method for suppressing joint pain, and the method for strengthening knee joint function, all descriptions of the composition for improving joint function described above may be applied to the composition for improving joint function.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention, and it will be obvious to those skilled in the art that the scope of the present invention is not to be construed as limited by these examples.

<Preparation Example 1> Preparation of turmeric extract

Natural Remides PVT.LTD. Turmeric obtained from (Location: India, Plot No.5B Veerasandra Indl. Area, 19th K.M. Stone, Hosur Road, Electronic City Post, Bangalore-560 100) was mixed with distilled water and filtered four times, and the filtered extract was concentrated and purified. By spray drying, a turmeric hot water extract was obtained. A turmeric extract was prepared by mixing the obtained turmeric hot water extract and turmeric derived oil (Curcuma oil) at a weight ratio of 99:1 (turmeric hot water extract: turmeric derived oil).

<Test Example 1> Tablet taking test

The compositions of Comparative Example 1, Comparative Example 2, and Example 1 were prepared using the compositions shown in Table 1 below, and each was prepared in the form of 700 mg tablets.

ingredient Comparative Example 1 Comparative Example 2 Comparative example 3 Comparative example 4 Example 1 Example 2 Turmeric extract ¹⁾ - 1000 1000 1000 850 850 magnesium - 0 100 0 100 100 amino acid - 0 0 50 ²⁾ 50 ²⁾ 50 ³⁾ Auxiliary ingredients ⁴⁾ 70 70 70 70 70 70 Hyaluronic acid 10 10 10 10 10 10 Excipients and Coatings 2020 1020 920 970 1020 1020 total 2100 2100 2100 2100 2100 2100 Unit: mg
1) Turmeric extract: extract obtained in Preparation Example 1 above
2) Composition of amino acids: valine - 10 mg, leucine - 10 mg, isoleucine - 10 mg, glutamine - 10 mg and arginine - 10 mg.
3) Composition of amino acids: Methionine - 10mg, Threonine - 10mg, Lysine - 10mg, Phenylalanine - 10mg, Tryptophan - 10mg
4) Auxiliary ingredient: A mixture of 28 mg of willow extract obtained from Samyoung Food Ingredients Co., Ltd. and 42 mg of ginger extract obtained from Samyoung Food Ingredients Co., Ltd.

120 adult men and women with knee pain or knee function abnormalities were divided into 6 groups, the tablets of Comparative Example 1 were given to 20 adult men and women in Comparative Example 1 group, and the tablets of Comparative Example 2 were given to 20 adult men and women. To Group 2, the tablets of Comparative Example 3 were administered to Group 3 of 20 adult men and women, the tablets of Comparative Example 4 were administered to Group 4 of Comparative Example 20 adult men and women, and the tablets of Example 1 were administered to Group 1 of Comparative Example 1 of 20 adult men and women. The tablets of Example 2 were provided to adult male and female Example 2 groups, and the experimental subjects of Comparative Example groups 1 to 4 and Example 1 and Group 2 took the provided tablets three times a day, a total of 2,100 mg. The test was conducted for 28 days.

In the tablet taking test of Test Example 1, the subjects were asked to record the degree of knee pain felt in daily life using a VAS (visual analogue scale) questionnaire immediately before the start of Test Example 1 and 28 days after Test Example 1. , this was scored.

The VAS questionnaire used for the experimental subjects was expressed on a 10-point scale from the starting point on the left (no pain) to the end on the right (severe pain), as follows.

[VAS survey]

Regarding the measurement results of the VAS questionnaire, the average scores of Comparative Example Groups 1 to 4 and Example Groups 1 and 2 are shown in Table 2 below.

VAS measurement results Comparative Example Group 1 Comparative Example Group 2 Comparative Example Group 3 Comparative Example Group 4 Example Group 1 Example Group 2 Test Example 1 Before Start 8.36 8.51 8.40 8.35 8.27 8.39 28 days after test example 1 8.01 6.30 4.95 5.02 3.31 4.80

As shown in Table 1, the test subjects in Comparative Example Groups 1 to 4 and Example Groups 1 and 2 all showed scores close to extreme pain before the start of Test Example 1, but after 28 days of Test Example 1, Afterwards, groups 1 to 4 of Comparative Examples showed a slight improvement in knee pain, while test subjects in groups 1 and 2 of Examples showed scores close to the pain-free state, confirming a significant improvement in knee pain.

<Test Example 2> Measurement of osteoarthritis index

In the test of taking the tablet of Test Example 1, the subjects were asked to use the Osteoarthritis Measurement Index Questionnaire (WOMAC, Western Ontario and McMaster Universities Osteoarthritis) on knee joint pain, stiffness, and knee joint function, immediately before and after the start of Test Example 1. After 28 days of Test Example 1, each was recorded and scored.

The osteoarthritis measurement index questionnaire used for the experimental subjects used a 4-point scale, and the specific contents of the questionnaire are as follows.

Regarding the measurement results of the osteoarthritis measurement index questionnaire, the scores corresponding to each item were summed (0 to 96 points), and the average scores of Comparative Example Groups 1 to 4 and Example Groups 1 and 2 for these summed scores were is shown in Table 3 below.

Osteoarthritis measurement index measurement results Comparative Example Group 1 Comparative Example Group 2 Comparative Example Group 3 Comparative Example Group 4 Example Group 1 Example Group 2 Test Example 1 Before Start 55.23 56.37 56.91 55.83 57.13 56.67 28 days after test example 1 52.14 42.13 36.97 37.84 23.08 34.55

As shown in Table 3, the test subjects in Comparative Example Groups 1 to 4 and Example Groups 1 and 2 all showed similar levels of osteoarthritis measurement scores before the start of Test Example 1, but after 28 days of Test Example 1, , Comparative Example groups 1 to 4 showed a slight improvement in osteoarthritis, while test subjects in Example groups 1 and 2 showed an improvement in scores of more than 50%, confirming a significant improvement in osteoarthritis.

<Test Example 3> Measurement of isokinetic muscle strength of lower limbs

In the tablet taking test of Test Example 1, lower limb muscle strength was measured on the test subjects immediately before the start of Test Example 1 and 28 days after Test Example 1.

To measure lower extremity muscle strength performed on test subjects, the angular velocity (speed selector) was set at 60°/sec using a measuring device on both legs of the test subject, and the test subject practiced with the device 3 times, and then performed the measurement exercise 5 times. Among the five measurements performed, the highest force values measured during extension and flexion were recorded, and the total amount of exercise measured during five times during extension and flexion was recorded, respectively. .

Regarding the highest force value and total momentum recorded in the lower limb muscle strength measurement, the average values of Comparative Example Groups 1 to 4 and Example 1 and Group 2 are shown in Table 4 below.

Results when stretching Comparative Example Group 1
(peak force/total momentum) Comparative Example Group 2
(peak force/total momentum) Comparative Example Group 3
(peak force/total momentum) Comparative Example Group 4
(peak force/total momentum) Example Group 1
(peak force/total momentum) Example Group 1
(peak force/total momentum) Test Example 1 Before Start 69.6/340.1 70.1/341.6 70.9/342.7 69.4/341.6 68.2/349.4 68.9/345.7 28 days after test example 1 68.7/341.6 71.5/348.1 77.51/362.9 76.29/358.3 82.1/389.7 78.3/369.5 Results when bending Comparative Example Group 1
(peak force/total momentum) Comparative Example Group 2
(peak force/total momentum) Comparative Example Group 3
(peak force/total momentum) Comparative Example Group 4
(peak force/total momentum) Example Group 1
(peak force/total momentum) Example Group 2
(peak force/total momentum) Test Example 1 Before Start 30.5/150 29.4/149.6 30.6/148.9 31.0/149.2 31.4/150.1 31.2/151.1 28 days after test example 1 29.8/149.4 30.3/150.1 38.6/188.6 36.8/185.8 45.2/215.5 40.9/190.5

(Unit: Peak force – N (kg·m/s ² ), Total momentum – J (N·m))

As shown in Table 4, the test subjects of Comparative Examples 1 to 4 and Examples 1 and 2 showed similar levels of peak force in extension and peak force in flexion before the start of Test Example 1. After 28 days of progress in 1, Comparative Example Groups 1 to 4 showed a slight improvement in the peak force during extension and peak force during flexion, while the test subjects in Example Groups 1 and 2 showed a slight improvement in peak force during extension and flexion. It showed an improvement of about 50% of the maximum strength, confirming a significant improvement in isokinetic strength.

<Test Example 4> Measurement of lower limb muscular endurance

In the tablet taking test of Test Example 1, muscle endurance was measured on the test subjects immediately before the start of Test Example 1 and 28 days after Test Example 1.

To measure lower extremity muscle strength performed on test subjects, the angular velocity (speed selector) was set at 180°/sec using a measuring device on both legs of the test subject, and the test subject was asked to perform 15 measurement exercises using the device. Measurements were performed 15 times. The highest force values measured during extension and flexion were recorded, and the total amount of exercise for five times measured during extension and flexion was recorded, respectively.

With respect to the highest force value and total exercise amount recorded in the lower limb muscle strength measurement, the average values of Comparative Example Groups 1 to 4 and Example 1 and Group 2 are shown in Table 5 below.

Results when stretching Comparative Example Group 1
(peak force/total momentum) Comparative Example Group 2
(peak force/total momentum) Comparative Example Group 3
(peak force/total momentum) Comparative Example Group 4
(peak force/total momentum) Example Group 1
(peak force/total momentum) Example Group 1
(peak force/total momentum) Test Example 1 Before Start 42/630 41.8/626 41.8/634 41/627.5 40/631 42.3/629.8 28 days after test example 1 41.1/624 42.5/624 50.7/711 50.1/708 58/760 52.8/742 Results when bending Comparative Example Group 1
(peak force/total momentum) Comparative Example Group 2
(peak force/total momentum) Comparative Example Group 3
(peak force/total momentum) Comparative Example Group 4
(peak force/total momentum) Example Group 1
(peak force/total momentum) Example Group 2
(peak force/total momentum) Test Example 1 Before Start 22.5/320 21.4/315 22.8/317 20.9/324 21.5/321 22.1/325 28 days after test example 1 23/317 22.1/324 30.8/397 30.4/382 35.1/430 31.5/418

(Unit: Peak force – N (kg·m/s ² ), Total momentum – J (N·m))

As shown in Table 5, the test subjects of Comparative Examples 1 to 4 and Examples 1 and 2 showed similar levels of total momentum during extension and total momentum during flexion before the start of Test Example 1. After 28 days of progress in 1, Comparative Example Groups 1 to 4 showed a slight improvement in peak force during extension and total momentum during flexion, while test subjects in Example Groups 1 and 2 showed peak force during extension and flexion. It showed an improvement of about 50% of the total exercise volume, confirming a significant improvement in muscular endurance.

Claims (12)

Contains turmeric extract, ginger extract, willow extract, magnesium and amino acids as active ingredients.
The content of the turmeric extract is 10% by weight to 80% by weight based on the total weight of the composition,
The content of magnesium is 2% to 20% by weight based on the total weight of the composition,
A composition for improving joint function, wherein the content of the amino acid is 0.1% to 10% by weight based on the total weight of the composition. delete delete delete According to paragraph 1,
A composition for improving joint function, wherein the amino acid is at least one selected from the group consisting of valine, leucine, isoleucine, glutamine, and arginine. According to clause 5,
A composition for improving joint function, characterized in that the amino acids are valine, leucine, isoleucine, glutamine and arginine. According to paragraph 1,
A composition for improving joint function, wherein the amino acid is at least one selected from the group consisting of methionine, threonine, lysine, phenylalanine, and tryptophan. In clause 7,
A composition for improving joint function, characterized in that the amino acids are methionine, threonine, lysine, phenylalanine and tryptophan. According to paragraph 1,
A composition for improving joint function, characterized in that the content of the ginger extract and willow extract is 3% by weight to 90% by weight based on the total weight of the composition. The composition for improving joint function according to any one of claims 1 and 5 to 9, wherein the composition is for suppressing joint pain. The composition for improving joint function according to any one of claims 1 and 5 to 9, wherein the composition is for strengthening joint muscles. The composition for improving joint function according to any one of claims 1 and 5 to 9, wherein the composition is used to enhance knee joint function.