KR102577026B1 - Skin anti-pollution composition comprising cocoon extract - Google Patents

Abstract

The present invention relates to a composition for skin anti-pollution containing silkworm cocoon extract. A composition for skin anti-pollution according to an embodiment of the present invention may include silkworm cocoon extract.
The composition for skin anti-pollution according to an embodiment of the present invention may have a skin anti-pollution effect against fine dust, organic or inorganic pollutants, etc. In addition, it is possible to manufacture functional cosmetics with desirable applicability due to excellent skin applicability and absorption.

Description

Composition for skin anti-pollution containing silkworm cocoon extract {SKIN ANTI-POLLUTION COMPOSITION COMPRISING COCOON EXTRACT}

The present invention relates to a composition for skin anti-pollution containing silkworm cocoon extract. More specifically, the object is to provide a composition for skin anti-pollution containing a silkworm cocoon extract that can have an anti-pollution effect on the skin against fine dust, organic or inorganic pollutants, etc.

The skin is a thin membrane surrounding the outside of the body, and its function is to protect the human body from physical and chemical stimuli from the external environment. It suppresses evaporation of moisture in the body and prevents excessive penetration of pollutants from the outside. Recently, as the use of chemicals has increased, the skin is exposed to environmental pollutants such as polycyclic aromatic hydrocarbons, aldehydes, nitrogen oxides, nitrates, and fine dust generated during the manufacturing, use, and disposal process, resulting in erythema, swelling, The incidence of mild skin problems such as itching, hives, and inflammation, and skin diseases such as atopy, psoriasis, and skin cancer is increasing.

On the other hand, as we enter modern society, environmental pollution becomes severe and the concentration of pollutants around the living radius increases, emerging as a social problem. These pollutants enter the body and accumulate, causing many problems, such as causing various diseases.

The above-mentioned pollutants not only penetrate into the body but also adversely affect the skin when they come into direct contact with the skin, such as dermatitis, skin rash, and skin necrosis. Therefore, the demand for cosmetics that can protect the skin not only from ultraviolet rays but also from pollutants is increasing.

An example of one of the above-mentioned pollutants is benzopyrene. The benzopyrene is produced due to incomplete combustion such as automobile exhaust gas or cigarette smoke, and is a toxic substance that causes cell damage through metabolic conversion to epoxide and reaction with DNA. Recently, as the news that it causes atopic dermatitis is encountered, adverse effects on the skin are revealed, and it is one of the dangerous substances that can cause skin deterioration due to problems such as cell mutation and cell damage.

Additionally, nitrogen oxides belong to the above-mentioned pollutants. The nitrogen oxide is a compound composed of nitrogen and oxygen and includes nitrogen monoxide, nitrogen dioxide, dinitrogen monoxide, dinitrogen trioxide, dinitrogen tetroxide, dinitrogen pentoxide, and their ionized products. In general, nitrogen gas is stable and it is difficult for the atoms constituting it to be split into two, but the bond can be broken when a very high temperature is applied. Often, high temperatures are formed inside a car's engine, and the car's exhaust gases contain a large amount of nitrogen oxides.

The above-described nitrogen oxides may include ammonium or its salt. Nitric acid, another form of nitrogen oxide, reacts with water to form nitric acid and can cause acid rain. The nitric acid combines with ammonium, an alkaline substance in the air, to produce ammonium nitrate. The ammonium nitrate is a particulate matter in the air that is secondary fine dust and has a negative effect on the human body. When the ammonium nitrate comes into contact with the human body, it causes inflammation in the eyes, nasal mucosa, and skin.

In addition, formaldehyde is one of the above-mentioned pollutants. The formaldehyde is a colorless gas with a strong irritating odor at room temperature and is also called methanal. The formaldehyde is easily created when materials containing carbon undergo incomplete combustion, and is synthesized in the air when sunlight and oxygen are added to hydrocarbons such as methane. The formaldehyde is a skin allergen, and when it comes into contact with the skin, it can cause problems such as skin rash, skin, and dermatitis.

The above-described contaminants cause direct inflammation or necrosis when in contact with the skin at high concentrations, and even residual amounts in the air cause continuous stress on the skin when continuously contacted, thus acting as a cause of skin aging.

Compared to the effects of the above pollutants on the skin, the public's awareness of the risks is still low, but as issues such as fine dust have recently emerged, the risks are gradually attracting attention, and the number of people who are gradually aware of the dangers of pollutants is increasing. It is increasing.

In addition, demand for the term Anti-pollution and these functional products is increasing as a compound word meaning a product that protects the skin from external harmful environments such as fine dust due to various pollutants and fine dust warnings. Especially in the cosmetics field, anti-pollution cosmetics are attracting attention. According to the Chinese market research company QY Research report, the anti-pollution skin care market for harmful environments including fine dust is expected to expand to 10 billion dollars by 2025. Interest is growing day by day.

On the other hand, compositions capable of protecting the skin from these contaminants have been studied, but so far, their diversity is lacking, the effect is not clear, and they are often made of difficult-to-manufacture or difficult-to-obtain materials, so they can be easily obtained from the surroundings. There is a need for the development of new compositions.

KR 10-2017-0053388 A KR 10-2018-0031487 A

The purpose of the present invention is to provide a composition for skin anti-pollution containing silkworm cocoon extract that has an anti-pollution effect on the skin against fine dust, organic or inorganic pollutants, etc.

An object of the present invention is to improve problems such as skin irritation and skin trouble caused by pollutants by protecting the skin from pollutants while minimizing skin irritation.

The purpose of the present invention is to provide a composition for skin anti-pollution containing silkworm cocoon extract in a formulation that is highly preferred due to its excellent skin applicability and absorption.

In order to achieve the above object, the composition for skin anti-pollution according to an embodiment of the present invention may include a silkworm cocoon extract.

A composition for skin anti-pollution according to another embodiment of the present invention may include silk fibroin.

A composition for skin anti-pollution according to another embodiment of the present invention may include silk sericin.

In the skin anti-pollution composition, the silkworm cocoon extract is water or alcohol having 1 to 10 carbon atoms; It may be extracted using any one selected from the group consisting of proteolytic enzymes and mixtures thereof.

In the skin anti-pollution composition, the silk fibroin may be hydrolyzed with a hydrolase.

In the skin anti-pollution composition, the silk sericin may be hydrolyzed with a hydrolytic enzyme.

A functional cosmetic according to another embodiment of the present invention may include the skin anti-pollution composition.

Cosmetics according to another embodiment of the present invention include a composition for skin anti-pollution, ointment, solution, suspension, emulsion, paste, gel, cream, lotion, serum, powder, soap, surfactant-containing cleansing , oil, powder foundation, emulsion foundation, wax foundation and spray formulations.

Hereinafter, the present invention will be described in more detail.

A composition for skin anti-pollution according to an embodiment of the present invention may include silkworm cocoon extract.

In the present invention, a 'cocoon' refers to a house that a silkworm makes by spewing out its own thread to cover its body. The cocoon is also composed of fibroin, a fibrous protein, and sericin, a rubbery protein surrounding it. Therefore, the term 'silk cocoon' as used in the present invention refers, on the other hand, to one containing silk fibroin or sericin.

'Silkworm cocoon extract' as used in the present invention shall include all hydrolysates hydrolyzed using proteolytic enzymes, extracts extracted using pulverized products as solvents, and extracts hydrolyzed with hydrolytic enzymes and extracted with solvents. .

In the present invention, 'skin anti-pollution' refers to improving skin contamination by pollutants such as fine dust, organic pollutants or inorganic pollutants, skin cell death or inhibition of skin cell proliferation, or skin condition deterioration.

In the present invention, pollutants may include fine dust, polycyclic aromatic hydrocarbons, aldehydes, and nitrogen oxides.

When using the skin anti-pollution composition containing the silkworm cocoon extract, anti-fouling activity against the pollutants can be exhibited.

A composition for skin anti-pollution according to another embodiment of the present invention may include silk fibroin.

Amino acids of silk protein are glycine, alanine, sericine, and tyrosine, and the main amino acids account for more than 90%. These silk proteins can be prepared as amino acid compositions with a certain sequence using hydrolytic enzymes.

Specifically, the production technologies for silk amino acids include largely known acid hydrolysis methods and enzyme decomposition methods. In addition, this silk protein can be decomposed into low-molecular peptides or amino acids through acid, alkali, or enzymatic hydrolysis to make it easy to digest and absorb. Among them, the enzymatic degradation method is involved in the specific binding of enzymes to proteins and cuts the linkage, so the degradation rate of protein decomposition to amino acids is very low, whereas acid hydrolysis method decomposes most of them to amino acids or peptides. In terms of the actual mass production process, the enzymatic decomposition method is simple, but the decomposition rate is low, the yield is low, and the human body absorption rate is low. It is composed of and contains more functional amino acids that have physiological activities useful to the human body.

The acid hydrolysis method of silk protein presented in the present invention can produce a product that is superior in amino acid composition and content of functional components showing physiological activity in the acid hydrolyzate.

In the case of using the silk fibroin composition, antifouling activity against the contaminant may be more excellent.

A composition for skin anti-pollution according to another embodiment of the present invention may include silk sericin.

In the case of using the silk fibroin composition, the antifouling activity against the pollutants including fine dust is more excellent and the effect of alleviating skin irritation can be doubled.

In the skin anti-pollution composition, the silkworm cocoon extract is water or alcohol having 1 to 10 carbon atoms; It may be extracted using any one selected from the group consisting of proteolytic enzymes and mixtures thereof.

In the skin anti-pollution composition, the silk fibroin may be hydrolyzed with a hydrolase.

Hydrolytic enzymes for the silk fibroin include Flavorzyme, Sumizyme, Protamex, Alcalase, Kojizyme, Zingibain, Bromela It may be any one selected from the group consisting of bromelain, papain, umamizyme, and mixtures thereof. In the case of the above range, an active ingredient for anti-fouling activity can be selectively obtained to improve the skin anti-pollution effect.

Preferably, the hydrolytic enzyme contains bromelain and is a mixed enzyme mixed with 5 to 30 parts by weight of Zingibain and 1 to 20 parts by weight of Umamizyme based on 100 parts by weight of bromelain. It can be. In the case of using the mixed enzyme, the antifouling activity of the obtained amino acid composition is greatly enhanced, so that the skin antipollution effect is improved. Therefore, it is possible to exhibit a higher skin anti-pollution effect even when a relatively small amount of silk fibroin hydrolyzate is included.

In the skin anti-pollution composition, the silk sericin may be hydrolyzed with a hydrolytic enzyme.

The hydrolytic enzymes for silk fibroin are Flavozyme, Sumizyme, Protamex, Alcalase, Kojizyme, Calpain, and Actini. It may be any one selected from the group consisting of Actinidin, Callupulin, and mixtures thereof. In the case of hydrolysis with a hydrolytic enzyme according to the above range, antifouling activity can be increased, and the effect of alleviating skin irritation caused by fine dust can be improved.

Preferably, the hydrolytic enzyme contains calpain and is a mixed enzyme containing 1 to 5 parts by weight of actinidin and 1 to 5 parts by weight of callupulin based on 100 parts by weight of calpain. It can be. If it is within the above range, the skin anti-pollution effect of the obtained amino acid composition can be increased and the effect of relieving skin irritation and skin trouble can be greatly increased. Therefore, when sericin hydrolyzed using the above mixed enzyme is included, the skin anti-pollution effect can be increased with a smaller amount, while the effect of alleviating skin irritation and skin trouble can be doubled.

The composition for skin anti-pollution may further include natural free plant extract. Through this, improvement effects such as whitening and wrinkle improvement can be provided as a functional cosmetic composition that provides the skin anti-pollution effect.

Preferably, the composition for skin anti-pollution includes a tangerine peel extract, and contains 1 to 10 parts by weight of cucumber extract, 1 to 10 parts by weight of walnut tree extract, and 1 to 5 parts by weight of glycolic flower extract, based on 100 parts by weight of the tangerine peel extract. , a mixed extract containing 1 to 5 parts by weight of Quercus extract and 1 to 5 parts by weight of dandelion extract may be further included.

When the mixed extract is further included, the skin soothing effect is enhanced, thereby improving skin irritation and improving skin trouble prevention activity.

A functional cosmetic according to another embodiment of the present invention may include the skin anti-pollution composition.

When the skin anti-pollution composition is prepared as a cosmetic composition or a functional cosmetic table, softening lotion, nutrient lotion, toner, mist, lotion, cream, essence, serum, pack, face wash (cleansing Cream, cleansing foam, cleansing water, cleansing powder), powder, foundation, lipstick, mascara, makeup base, eyeliner, eye shadow, blush, shampoo, conditioner, conditioner, hair gel, hair serum, hair essence, body lotion, body wash It can be manufactured in the form of poetry, body spray, etc.

The excipient is not limited thereto, but may include, for example, a skin softener, a skin penetration enhancer, a colorant, a fragrance, an emulsifier, a thickening agent, and a solvent. In addition, it may additionally contain fragrances, pigments, disinfectants, antioxidants, preservatives, and moisturizers, and may include thickeners, inorganic salts, synthetic polymer materials, etc. for the purpose of improving physical properties. For example, when preparing a face wash or soap using the cosmetic composition of the present invention, it can be easily produced by adding the biarylamide derivative of the present invention to a regular face wash or soap base. When preparing a cream, it can be produced by adding the biarylamide derivative of the present invention to a general oil-in-water (O/W) cream base. Here, synthetic or natural materials such as proteins, minerals, and vitamins can be added for the purpose of improving physical properties, such as fragrances, chelating agents, pigments, antioxidants, and preservatives.

Cosmetics according to another embodiment of the present invention include a composition for skin anti-pollution, ointment, solution, suspension, emulsion, paste, gel, cream, lotion, serum, powder, soap, surfactant-containing cleansing , may be manufactured in one of oil, powder foundation, emulsion foundation, wax foundation, and spray formulations.

The present invention is to provide a composition for skin anti-pollution comprising a silkworm cocoon extract capable of having a skin anti-fouling effect against fine dust, organic or inorganic pollutants, and the like.

The present invention is intended to improve problems such as skin irritation and skin trouble caused by pollutants by protecting the skin from pollutants while minimizing skin irritation.

The present invention is to provide a composition for skin anti-pollution comprising a silkworm cocoon extract composed of a highly preferred formulation due to its excellent skin applicability and absorption.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in many different forms and is not limited to the embodiments described herein.

[Preparation Example 1: Preparation of silkworm cocoon extract]

1. Preparation of silkworm cocoon extract (E1)

The cocoon powder was dried, extracted at high temperature and high pressure with alcohol, filtered, and concentrated in vacuum to prepare a powdery cocoon extract (E1).

2. Preparation of fibroin extract (E2)

Silk fibroin was mixed with purified water and hydrolyzed by treating it with 1w% Flavozyme. Afterwards, it was heat treated for 10 minutes to remove enzyme activity and then freeze-dried to prepare a powdery extract (E2).

3. Preparation of sericin extract (E3)

Silk sericin was mixed with purified water and hydrolyzed by treating it with 1w% Flavozyme. Afterwards, it was heat treated for 10 minutes to remove enzyme activity and then freeze-dried to prepare a powdery extract (E3).

[Experimental Example 1: Skin anti-pollution evaluation of silkworm cocoon extract]

1. Skin stability evaluation

As an MTT assay experiment for melanocytes (B16F10) and keratinocytes (HaCaT), cell viability was measured after each suspension in purified water at each concentration (50 mg/L) based on E1 to E3.

Cytotoxicity was performed by modifying Mosmann's method of measuring cell viability using the MTT {3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide} reagent. Fibroblasts (HDF), melanocytes (B16F10), and keratinocytes (HaCaT) were each distributed in a 96-well plate at a concentration of 1×10 ⁴ cells/well and cultured at 37°C and 5% CO ₂ for 48 hours. did.

The culture medium was removed, and the samples were cultured in medium treated at different concentrations for 48 hours, then the medium was removed and washed repeatedly with PBS (Phosphate buffered saline).

MTT was dissolved in PBS at 5 mg/mL, 50 L was added, and cultured at 37°C and 5% CO ₂ for 24 hours. 100L of DMSO (dimethyl sulfoxide) was added per well, stirred for 10 minutes, and absorbance was measured at 540 nm.

As a result, cell survival rates of more than 80% were confirmed for both E1 to E3 compared to the control treated with purified water. Therefore, it was confirmed that neither E1 to E3 had problems such as cytotoxicity.

Control E1 E2 E3 Cell survival rate (%) 100 >80 >80 >80

2. Evaluation of resistance activity to aromatic compounds

After washing the silicon (1cm x 1cm) specimen, it is divided into a purified water treatment group (control) and a treatment group by applying E1 to E3 mixed with purified water, and naphthalene and acenaphthylene are applied to each specimen. , Acenaphthene, Fluorene, and Benzopyrene were immersed in a solution containing 600 ppm for 1 hour or more, and then dried at room temperature.

Afterwards, each specimen was washed with phosphate-buffered saline solution, the contents of naphthalene, acenathylene, acenaphthene, fluorene, and benzopyrene remaining in the specimen were analyzed, the value of the control was fixed at 10, and the results were compared with the control results. The results of each example were evaluated on an index of 1 to 10. The lower the index number, the better the resistance to aromatic compounds.

The results are shown in [Table 2] below.

Control E1 E2 E3 Resistance to aromatic compounds 10 8.5 7.3 8.7

(Unit: index)

Referring to [Table 2], it can be confirmed that resistance to anti-aromatic compounds is improved in the case of E1 to E3 according to the present invention.

3. Evaluation of resistance activity to formaldehyde

Human keratinocytes HaCaT were cultured in a 96-well plate at a concentration of 1 × 10 ⁴ cells/ml, treated with formaldehyde (1 μg/mL), and divided into an untreated group (control) and a group treated with E1 to E3. They were differentiated and cultured for 24 hours. After that, MTT solution at a concentration of 5 mg/mL was added and cultured for 3 hours, the medium was removed, 150 ㎕ of dimethyl sulfoxide (DMSO) was added to each well, shaken for 10 minutes, and the absorbance was measured at 570 nm (reference 655 nm). For comparison, cell viability was compared with the control results and evaluated on an index of 1 to 10. The higher the index number, the better the resistance to formaldehyde.

The results are shown in [Table 3].

Control E1 E2 E3 Resistance to formaldehyde One 1.7 2.8 3.4

(Unit: index)

Referring to [Table 3], it can be confirmed that resistance to formaldehyde is improved in the case of E1 to E3 according to the present invention.

4. Evaluation of resistance activity against fine dust

After washing and drying the silicon (1 cm x 1 cm) specimen, the same amount of fine dust mimetic was applied, and then purified water (control) and E1 to E3 mixed with purified water were flowed to wash. After drying each specimen, the specimen was photographed, and the fine dust removal activity was evaluated through related analysis of the enlarged image. For objective evaluation, it was compared with the control and evaluated on an index of 1 to 10. The lower the index number, the better the resistance to fine dust.

The results are shown in [Table 4] below.

Control E1 E2 E3 Resistance to fine dust simulants 10 8.1 7.2 8.6

(Unit: index)

Referring to [Table 4], it can be confirmed that resistance to fine dust mimics is improved in the case of E1 to E3 according to the present invention.

[Preparation Example 2: Preparation of extract by mixed hydrolysis enzyme]

1. Silk fibroin extract hydrolyzed with mixed hydrolytic enzyme

Fibroin extracts P1 to P6 were prepared in the same manner as in E2 using mixed hydrolases as shown in [Table 5] below.

P1 P2 P3 P4 P5 P6 Bromelain 100 100 100 100 100 100 Zingibane 2 2 5 20 30 40 Umamizyme - 0.5 One 10 20 30

(Unit: parts by weight)

2. Silk sericin extract hydrolyzed with mixed hydrolase

Sericin extracts C1 to C5 were prepared in the same manner as E3, using mixed hydrolases as shown in Table 6 below.

C1 C2 C3 C4 C5 Calpain 100 100 100 100 100 Actinidin 0.1 One 3 5 10 Callupulin 0.1 One 3 5 10

(Unit: parts by weight)

[Experimental Example 2: Skin anti-pollution evaluation for each extract]

The anti-pollution effects of P1 to P6 and C1 to C5 were evaluated in the same manner as in Experimental Example 1, and the results are shown in Table 7 and Table 8 below.

P1 P2 P3 P4 P5 P6 Resistance to aromatic compounds 8.1 7.6 6.4 6.8 7.4 7.4 Resistance to formaldehyde 2.2 2.7 4.2 4.2 3.9 3.0 Resistance to fine dust simulants 8.4 8.1 6.1 6.7 6.4 7.7

(Unit: index)

C1 C2 C3 C4 C5 Resistance to aromatic compounds 9.1 8.8 8.1 7.9 8.6 Resistance to formaldehyde 3.1 5.6 5.3 5.7 3.3 Resistance to fine dust simulants 8.5 8.2 7.9 7.7 7.9

(Unit: index)

Referring to [Table 7], it can be seen that the overall skin anti-pollution effect is improved in the case of P3 to P5 compared to E2. Therefore, it can be seen that when the silk fibroin extract prepared using the mixed hydrolytic enzyme in the above range is included, it can exhibit better resistance activity against contaminants with a lower content.

Also, referring to [Table 8], it can be seen that the overall skin anti-pollution effect is improved in the case of C2 to C4 compared to E3. In particular, it can be seen that resistance to formaldehyde is greatly improved. Therefore, it can be seen that when the silk sericin extract prepared using the mixed hydrolase in the above range is included, it can exhibit better resistance activity against pollutants with a lower content.

Furthermore, referring to [Table 7] and [Table 8], it can be seen that when combining P3 to P5 and C2 to C4, resistance activity against various pollutants can be increased. Therefore, when P3 to P5 and C2 to C4 are combined with each other, a cosmetic composition with excellent resistance to various pollutants can be provided.

[Preparation Example 3: Preparation of plant extract]

1. Preparation of plant extract

Each plant material is dried and pulverized and then subjected to hot water extraction to produce tangerine peel extract (H1), cucumber extract (H2), walnut tree extract (H3), glycolic flower extract (H4), Quercus tree extract (H5), and dandelion extract (H6). was manufactured.

2. Preparation of mixed composition of plant extracts

The mixed plant extract F1 was prepared by mixing H1 to H6 according to the composition shown in Table 9 below.

F1 F2 F3 F4 F5 F6 F7 F8 H1 100 100 100 100 100 100 100 100 H2 10 - - 0.1 One 5 10 20 H3 - 10 - 0.1 One 5 10 20 H4 - - - 0.1 One 3 5 10 H5 - - - 0.1 One 3 5 10 H6 - - 10 0.1 One 3 5 10

(Unit: parts by weight)

[Experimental Example 3: Skin soothing effect experiment]

In order to confirm the skin soothing effect of H1, F1 to F8, mask packs of H1, F1 to F8 were prepared, and 10 test subjects were asked to evaluate the moisturizing properties of each example. The results were evaluated on an index of 1 to 10. In addition, in order to test the skin soothing effect, ethanol was applied to the skin of 10 test subjects, wiped off, and then the skin soothing effect according to the use of the mask packs H1, F1 to F8 was evaluated, and the results were evaluated as an index of 1 to 10. evaluated.

The average values of each experiment result are shown in [Table 10] below. Meanwhile, the higher the number, the better the moisturizing and skin soothing effects.

H1 F1 F2 F3 F4 F5 F6 F7 F8 Moisturizing 5 4.7 4.8 4.7 4.9 6.8 7.4 7.2 5.7 Skin soothing effect 5 4.4 4.3 4.1 4.6 6.4 6.8 6.4 5.1

(Unit: index)

Referring to [Table 10], it can be seen that the mixed composition with a constant mixing ratio has superior moisturizing and skin soothing effects compared to the tangerine peel extract. In particular, it can be seen that F5 to F7 have a significant synergistic effect.

Therefore, when the mixture of the above plant extracts is further included, a functional cosmetic composition with doubled skin anti-pollution effect and skin moisturizing and skin irritation relieving effect can be provided.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements made by those skilled in the art using the basic concept of the present invention defined in the following claims are also possible. falls within the scope of rights.

Claims (8)

Contains silk fibroin or silk sericin,
The silk fibroin is hydrolyzed with a mixed enzyme mixed with 5 to 30 parts by weight of Zingibain and 1 to 20 parts by weight of Umamizyme based on 100 parts by weight of bromelain,
The silk sericin is hydrolyzed with a mixed enzyme containing 1 to 5 parts by weight of actinidin and 1 to 5 parts by weight of callupulin, based on 100 parts by weight of calpain.
Composition for skin anti-pollution. delete delete delete delete delete Containing the composition for skin anti-pollution according to claim 1
Functional cosmetics. Containing the composition for skin anti-pollution according to claim 1,
Manufactured in any of the following formulations: ointments, solutions, suspensions, emulsions, pastes, gels, creams, lotions, serums, powders, soaps, surfactant-containing cleansers, oils, powder foundations, emulsion foundations, wax foundations and spray formulations.
cosmetics.