KR102568238B1 - 시험관내 용혈 검출 및 전혈 샘플에서 적어도 하나의 혈액 파라미터의 교정 - Google Patents
시험관내 용혈 검출 및 전혈 샘플에서 적어도 하나의 혈액 파라미터의 교정 Download PDFInfo
- Publication number
- KR102568238B1 KR102568238B1 KR1020207020265A KR20207020265A KR102568238B1 KR 102568238 B1 KR102568238 B1 KR 102568238B1 KR 1020207020265 A KR1020207020265 A KR 1020207020265A KR 20207020265 A KR20207020265 A KR 20207020265A KR 102568238 B1 KR102568238 B1 KR 102568238B1
- Authority
- KR
- South Korea
- Prior art keywords
- hemolysis
- whole blood
- blood sample
- data
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 275
- 239000008280 blood Substances 0.000 title claims abstract description 274
- 206010018910 Haemolysis Diseases 0.000 title claims abstract description 231
- 230000008588 hemolysis Effects 0.000 title claims abstract description 230
- 238000000338 in vitro Methods 0.000 title claims abstract description 57
- 238000001514 detection method Methods 0.000 title description 15
- 238000001727 in vivo Methods 0.000 claims abstract description 91
- 238000004458 analytical method Methods 0.000 claims abstract description 46
- 238000000034 method Methods 0.000 claims abstract description 41
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000011591 potassium Substances 0.000 claims abstract description 28
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 28
- 238000004590 computer program Methods 0.000 claims abstract description 12
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims abstract description 6
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims abstract description 6
- 238000012545 processing Methods 0.000 claims description 37
- 238000005259 measurement Methods 0.000 claims description 16
- 238000004364 calculation method Methods 0.000 claims description 11
- 239000011575 calcium Substances 0.000 claims description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 8
- 229910052791 calcium Inorganic materials 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 230000002949 hemolytic effect Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 127
- 108010054147 Hemoglobins Proteins 0.000 description 18
- 102000001554 Hemoglobins Human genes 0.000 description 18
- 210000003743 erythrocyte Anatomy 0.000 description 12
- 239000007789 gas Substances 0.000 description 11
- 210000002381 plasma Anatomy 0.000 description 10
- 230000003287 optical effect Effects 0.000 description 9
- 238000003556 assay Methods 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 239000012491 analyte Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 108010061951 Methemoglobin Proteins 0.000 description 4
- 239000003146 anticoagulant agent Substances 0.000 description 4
- 229940127219 anticoagulant drug Drugs 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000015271 coagulation Effects 0.000 description 4
- 238000005345 coagulation Methods 0.000 description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 230000002503 metabolic effect Effects 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000004973 liquid crystal related substance Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 2
- 108010082126 Alanine transaminase Proteins 0.000 description 2
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 2
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 238000007813 chromatographic assay Methods 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 238000004868 gas analysis Methods 0.000 description 2
- 230000002489 hematologic effect Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- VVJYUAYZJAKGRQ-UHFFFAOYSA-N 1-[4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C(O)C1 VVJYUAYZJAKGRQ-UHFFFAOYSA-N 0.000 description 1
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 1
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 1
- 102000013563 Acid Phosphatase Human genes 0.000 description 1
- 108010051457 Acid Phosphatase Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000003846 Carbonic anhydrases Human genes 0.000 description 1
- 108090000209 Carbonic anhydrases Proteins 0.000 description 1
- 108010003320 Carboxyhemoglobin Proteins 0.000 description 1
- 102000004420 Creatine Kinase Human genes 0.000 description 1
- 108010042126 Creatine kinase Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000017011 Glycated Hemoglobin A Human genes 0.000 description 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000002682 Hyperkalemia Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 108010002255 deoxyhemoglobin Proteins 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000012953 feeding on blood of other organism Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000012520 frozen sample Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 102000018146 globin Human genes 0.000 description 1
- 108060003196 globin Proteins 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 108091005995 glycated hemoglobin Proteins 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 208000034737 hemoglobinopathy Diseases 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000000968 medical method and process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
- G01N33/48792—Data management, e.g. communication with processing unit
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Ecology (AREA)
- Human Computer Interaction (AREA)
- Optics & Photonics (AREA)
- Databases & Information Systems (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201700728 | 2017-12-20 | ||
| DKPA201700728 | 2017-12-20 | ||
| PCT/EP2018/085124 WO2019121459A1 (en) | 2017-12-20 | 2018-12-17 | In-vitro hemolysis detection and correction of at least one blood parameter in a whole blood sample |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20200098628A KR20200098628A (ko) | 2020-08-20 |
| KR102568238B1 true KR102568238B1 (ko) | 2023-08-17 |
Family
ID=64744735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207020265A Active KR102568238B1 (ko) | 2017-12-20 | 2018-12-17 | 시험관내 용혈 검출 및 전혈 샘플에서 적어도 하나의 혈액 파라미터의 교정 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20210088502A1 (https=) |
| EP (1) | EP3729078B1 (https=) |
| JP (3) | JP6941237B2 (https=) |
| KR (1) | KR102568238B1 (https=) |
| CN (2) | CN111386464B (https=) |
| WO (1) | WO2019121459A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3969901A1 (en) | 2019-05-14 | 2022-03-23 | Radiometer Medical ApS | Methods for determining blood gas or metabolic parameters |
| WO2023099752A1 (en) | 2021-12-03 | 2023-06-08 | Radiometer Medical Aps | Method to determine impact on analytes due to cytolysis in a sample |
| CN114707407B (zh) * | 2022-03-29 | 2024-12-27 | 攀钢集团总医院 | 一种血气分析仪所测钾离子结果的校正方法 |
| IT202200022275A1 (it) * | 2022-10-28 | 2024-04-28 | Datamed S R L | Dispositivo e metodo per misurare una pluralità di parametri del sangue mediante intelligenza artificiale |
| CN116298328A (zh) * | 2022-12-06 | 2023-06-23 | 北京大学第三医院（北京大学第三临床医学院） | 一种用于测定溶血标本血钾浓度的试剂盒 |
| CA3278465A1 (en) * | 2023-01-30 | 2024-08-08 | Siemens Healthcare Diagnostics Inc. | METHODS AND APPARATUS FOR DETECTING HEMOLYSIS |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170248618A1 (en) | 2014-09-30 | 2017-08-31 | Siemens Healthcare Diagnostics Inc. | Hemolysis detection device, system and method |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6350743A (ja) * | 1986-08-20 | 1988-03-03 | Hitachi Ltd | 溶血のある血液試料の分析方法 |
| SE530596C2 (sv) * | 2006-10-13 | 2008-07-15 | Mathias Karlsson | Metod att fastställa syrebrist i blod från skalpen under förlossning |
| KR101423770B1 (ko) * | 2008-01-08 | 2014-07-25 | 엘지전자 주식회사 | 전혈과 용혈에 의한 헤모글로빈의 정량적 측정 방법 및측정 장치 |
| SE536634C2 (sv) * | 2011-12-09 | 2014-04-15 | Hemcheck Sweden Ab | Anordning för detektion av hemolys |
| US20130274148A1 (en) * | 2012-04-11 | 2013-10-17 | Illumina, Inc. | Portable genetic detection and analysis system and method |
| RU2682324C2 (ru) * | 2014-05-23 | 2019-03-19 | Нова Биомедикэл Корпорэйшн | Система и способ определения гемолиза |
| JP6670830B2 (ja) * | 2014-06-13 | 2020-03-25 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | クロマトグラフ検出パッドを使用する溶血検出 |
| US9547899B1 (en) * | 2014-10-07 | 2017-01-17 | University Of South Florida | Mobile hemolysis detection in whole blood samples |
| DK3234570T3 (da) * | 2014-12-19 | 2022-11-28 | Siemens Healthcare Diagnostics Inc | Hemolysedetektion ved anvendelse af intracellulære analytkoncentrationer |
| JP2021143309A (ja) * | 2020-03-13 | 2021-09-24 | Ｅｍｇルブリカンツ合同会社 | 潤滑油組成物 |
-
2018
- 2018-12-17 KR KR1020207020265A patent/KR102568238B1/ko active Active
- 2018-12-17 WO PCT/EP2018/085124 patent/WO2019121459A1/en not_active Ceased
- 2018-12-17 CN CN201880076071.6A patent/CN111386464B/zh active Active
- 2018-12-17 EP EP18822042.0A patent/EP3729078B1/en active Active
- 2018-12-17 JP JP2020533766A patent/JP6941237B2/ja active Active
- 2018-12-17 US US16/954,433 patent/US20210088502A1/en active Pending
- 2018-12-17 CN CN202310062926.2A patent/CN116087480A/zh active Pending
-
2021
- 2021-09-02 JP JP2021143309A patent/JP7253595B2/ja active Active
-
2023
- 2023-03-24 JP JP2023048691A patent/JP2023078412A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170248618A1 (en) | 2014-09-30 | 2017-08-31 | Siemens Healthcare Diagnostics Inc. | Hemolysis detection device, system and method |
Non-Patent Citations (3)
| Title |
|---|
| Ismail et al., BMJ, Vol. 330, No. 7497, 2005, pp. 949. |
| J.Vermeer et al., Clinical Chemicstry and Laboratory Medi, Vol. 45, No. 1, 2007, pp. 114-119. |
| Lippi et al., In Vitro and In Vivo Hemolysis - An Unresolved Dispute in Laboratory Medicine, 2012, pp. 35-37. |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3729078B1 (en) | 2024-08-21 |
| JP2023078412A (ja) | 2023-06-06 |
| JP7253595B2 (ja) | 2023-04-06 |
| CN111386464B (zh) | 2023-01-24 |
| WO2019121459A1 (en) | 2019-06-27 |
| JP6941237B2 (ja) | 2021-09-29 |
| US20210088502A1 (en) | 2021-03-25 |
| CN111386464A (zh) | 2020-07-07 |
| EP3729078A1 (en) | 2020-10-28 |
| JP2021192046A (ja) | 2021-12-16 |
| JP2021508048A (ja) | 2021-02-25 |
| CN116087480A (zh) | 2023-05-09 |
| KR20200098628A (ko) | 2020-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102568238B1 (ko) | 시험관내 용혈 검출 및 전혈 샘플에서 적어도 하나의 혈액 파라미터의 교정 | |
| Dukić et al. | Blood gas testing and related measurements: National recommendations on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine | |
| KR101136654B1 (ko) | 시료채취 및 분석 기구 | |
| JP6522556B2 (ja) | 血液検査キット、及びそれを用いた分析方法 | |
| KR102080417B1 (ko) | 혈액 검사 키트 및 혈액 분석 방법 | |
| EP1690088A1 (en) | Hematocrit and analyte concentration determination | |
| US20120295359A1 (en) | Automated method and apparatus for detecting erroneous sample collection in clinical assays | |
| WO2017006962A1 (ja) | 血液検査キット及び血液分析方法 | |
| EP3321372B1 (en) | Blood analysis method and blood test kit | |
| CN113330315A (zh) | 糖尿病的微量取样检测 | |
| Larsen et al. | Blood values of juvenile northern elephant seals (Mirounga angustirostris) obtained using a portable clinical analyzer | |
| Barbara et al. | Dacie & Lewis practical haematology | |
| Agarwal et al. | Evaluation of the analytical performance of the modified enterprise point-of-care blood gas and electrolyte analyzer in a pediatric hospital | |
| Whitsel et al. | Renal function | |
| Lemburg | Point-of-care hemoglobin testing: Methods and relevance to combat anemia. | |
| Carraro | Blood Gas Analysis | |
| Wennecke | Useful tips to avoid preanalytical errors in blood gas testing: electrolytes | |
| ES2751701T3 (es) | Procedimientos y sistemas para mejorar la precisión de las mediciones para volúmenes de muestra reducidos | |
| Wiener | Principles and problems of blood glucose measurement | |
| HK40048617A (en) | Microsampling detection in diabetes | |
| Pereira et al. | Validação do hemoglobinômetro portátil Hemo_Vet em cães | |
| Pereira et al. | A validation of Hemo_Vet, a portable hemoglobinometer, in dogs | |
| Washington et al. | The Role of Point-of-Care Testing in a Value-Based Healthcare Landscape |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20200713 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PA0201 | Request for examination | ||
| PG1501 | Laying open of application | ||
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20220125 Patent event code: PE09021S01D |
|
| E90F | Notification of reason for final refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Final Notice of Reason for Refusal Patent event date: 20220719 Patent event code: PE09021S02D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20230125 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20230512 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20230814 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20230814 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration |