KR102523186B1 - Composition for animal-based chewable soft capsule and animal-based chewable soft capsule using the same - Google Patents
Composition for animal-based chewable soft capsule and animal-based chewable soft capsule using the same Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/34—Sugar alcohols
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/25—Exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
- A23L29/281—Proteins, e.g. gelatin or collagen
- A23L29/284—Gelatin; Collagen
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Abstract
본 발명은 동물성 츄어블 연질캡슐용 조성물에 관한 것으로, 더욱 상세하게는 물 없이 섭취할 수 있으면서도, 저작감이 우수하고, 입에 넣고 씹을 때 치아에 부착하지 않을 뿐만 아니라, 피막 리본 형성성 저하에 따른 내부 충진물의 누액이나 백화현상 또는 연질캡슐 간의 부착 등의 불량이 발생하지 않는 동물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 동물성 츄어블 연질캡슐에 관한 것이다.The present invention relates to a composition for animal-based chewable soft capsules, and more specifically, to a composition that can be ingested without water, has excellent chewing sensation, does not adhere to teeth when chewed in the mouth, and also reduces the formation of a film ribbon. The present invention relates to a composition for animal-based chewable soft capsules that does not cause defects such as leakage or whitening of an internal filler or adhesion between soft capsules, and animal-based chewable soft capsules formed through the composition.
Description
본 발명은 동물성 츄어블 연질캡슐용 조성물에 관한 것으로, 더욱 상세하게는 물 없이 섭취할 수 있으면서도, 저작감이 우수하고, 입에 넣고 씹을 때 치아에 부착하지 않을 뿐만 아니라, 피막 리본 형성성 저하에 따른 내부 충진물의 누액이나 백화현상 또는 연질캡슐 간의 부착 등의 불량이 발생하지 않는 동물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 동물성 츄어블 연질캡슐에 관한 것이다.The present invention relates to a composition for animal-based chewable soft capsules, and more specifically, to a composition that can be ingested without water, has excellent chewing sensation, does not adhere to teeth when chewed in the mouth, and also reduces the formation of a film ribbon. The present invention relates to a composition for animal-based chewable soft capsules that does not cause defects such as leakage or whitening of an internal filler or adhesion between soft capsules, and animal-based chewable soft capsules formed through the composition.
최근 건강기능식품의 시장은 꾸준한 성장을 기록하고 있다. 종래에는 중장년층의 건강보조식품으로 주로 소비되었으나 현재는 어린아이부터 노인용까지 다양한 제품들이 판매되고 있다. 건강기능식품의 제형 또한 캡슐제, 정제, 분말제 등이 주를 이루었으나 액제, 환, 젤리, 구미젤리 등의 새로운 제형이 추가되어 다양한 제형의 제품들이 판매되고 있으며 또한 점점 복용이 편리한 제형으로 개발되고 있는 추세이다.Recently, the health functional food market has recorded steady growth. In the past, it was mainly consumed as a health supplement for middle-aged and elderly people, but now various products from children to the elderly are sold. As for the formulation of health functional foods, capsules, tablets, powders, etc. were the main ones, but new formulations such as liquids, pills, jellies, and gummy jellies were added, and products of various formulations were sold, and more and more convenient formulations were developed. It is a trend that is becoming
현재 캡슐제의 대표적인 제형으로는 경질 캡슐제와 연질 캡슐제가 있다. 연질 캡슐은 1종 이상의 약리학적 유효성분 또는 기능성 식품의 성분을 1종 이상의 액상(또는 반고상)의 부형제(excipients)에 용해 또는 현탁시켜, 액상 또는 페이스트 상의 물질을 제조하여 젤라틴 피막에 충전하는 제형이다.Currently, representative formulations of capsules include hard capsules and soft capsules. Soft capsules are formulations in which one or more pharmacologically active ingredients or functional food ingredients are dissolved or suspended in one or more liquid (or semi-solid) excipients to prepare a liquid or paste-like substance and fill the gelatin shell. am.
일반적으로 연질 캡슐은 물과 함께 기도구강 내로 삼키는 방식으로 섭취한다. 그러나, 연질 캡슐은 어린이나 노약자 또는 개인적인 취향에 따라 불편함을 야기할 수 있고, 물이 없으면 섭취할 수 없다는 단점이 있다.In general, soft capsules are ingested by swallowing into the airway orally with water. However, the soft capsule may cause discomfort depending on children, the elderly, or personal taste, and has a disadvantage in that it cannot be ingested without water.
이에 따라, 물 없이 섭취할 수 있으면서도, 저작감이 우수하고, 입에 넣고 씹을 때 치아에 부착하지 않을 뿐만 아니라, 피막 리본 형성성 저하에 따른 내부 충진물의 누액이나 백화현상 또는 연질캡슐 간의 부착 등의 불량이 발생하지 않는 츄어블 연질캡슐에 대한 개발이 필요한 실정이다.As a result, it can be ingested without water, has excellent chewing sensation, does not adhere to teeth when put in the mouth and chewed, and leaks or whitening of the inner filling due to the decrease in film ribbon formation or adhesion between soft capsules There is a need to develop a chewable soft capsule that does not cause defects.
본 발명은 상술한 문제점을 해결하기 위해 안출된 것으로, 물 없이 섭취할 수 있으면서도, 저작감이 우수하고, 입에 넣고 씹을 때 치아에 부착하지 않을 뿐만 아니라, 피막 리본 형성성 저하에 따른 내부 충진물의 누액이나 백화현상 또는 연질캡슐 간의 부착 등의 불량이 발생하지 않는 동물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 동물성 츄어블 연질캡슐을 제공하는데 목적이 있다.The present invention has been made to solve the above-mentioned problems, and can be ingested without water, has excellent chewing sensation, does not adhere to teeth when chewing in the mouth, and provides an internal filling material due to a decrease in film ribbon formation. An object of the present invention is to provide a composition for animal-based chewable soft capsules that does not cause defects such as leakage, whitening, or adhesion between soft capsules, and animal-based chewable soft capsules formed through the composition.
상술한 과제를 해결하기 위해 본 발명은, 감자전분, 상기 감자전분 100 중량부에 대하여 아라비아검을 0.5 ~ 10 중량부 및 젤라틴을 150 ~ 270 중량부로 포함하는 동물성 츄어블 연질캡슐용 조성물을 제공한다.In order to solve the above problems, the present invention provides a composition for animal-based chewable soft capsules comprising potato starch, 0.5 to 10 parts by weight of gum arabic and 150 to 270 parts by weight of gelatin based on 100 parts by weight of the potato starch.
본 발명의 일 실시예에 의하면, 상기 감자전분 100 중량부에 대하여 상기 아라비아검을 0.8 ~ 8.5 중량부 및 상기 젤라틴을 160 ~ 250 중량부로 포함할 수 있다.According to one embodiment of the present invention, 0.8 to 8.5 parts by weight of the gum arabic and 160 to 250 parts by weight of the gelatin may be included with respect to 100 parts by weight of the potato starch.
또한, 상기 동물성 츄어블 연질캡슐용 조성물은 글리세린을 더 포함할 수 있고, 상기 젤라틴 및 글리세린은 중량비가 1 : 0.6 ~ 2.8일 수 있다.In addition, the animal-based chewable soft capsule composition may further include glycerin, and the weight ratio of the gelatin and glycerin may be 1:0.6 to 2.8.
또한, 상기 감자전분 100 중량부에 대하여 글리세린을 190 ~ 400 중량부로 더 포함할 수 있다.In addition, 190 to 400 parts by weight of glycerin may be further included based on 100 parts by weight of the potato starch.
또한, 상기 감자전분 100 중량부에 대하여 에리스리톨을 30 ~ 80 중량부로 더 포함할 수 있다.In addition, 30 to 80 parts by weight of erythritol may be further included based on 100 parts by weight of the potato starch.
또한, 상기 감자전분은 감자 유래의 변성전분일 수 있다.In addition, the potato starch may be potato-derived modified starch.
또한, 상기 감자 유래의 변성전분은, 산화전분(Oxidized Starch), 아세틸아디프산이전분(Acetylated Distarch Adipate), 아세틸인산이전분(Acetylated Distarch Phosphate), 옥테닐호박산나트륨전분(Starch Sodium Octenyl Succinate), 인산이전분(Distarch Phosphate), 인산일전분(Monostarch Phosphate), 인산화인산이전분(Phosphated Distarch Phosphate), 초산전분(Starch Acetate), 히드록시프로필인산이전분(Hydroxypropyl Distarch Phosphate) 및 히드록시프로필전분(Hydroxypropyl Starch)로 이루어진 군에서 선택된 1종 이상을 포함할 수 있다.In addition, the potato-derived modified starch includes oxidized starch, acetylated distarch adipate, acetylated distarch phosphate, starch sodium octenyl succinate, Distarch Phosphate, Monostarch Phosphate, Phosphated Distarch Phosphate, Starch Acetate, Hydroxypropyl Distarch Phosphate and Hydroxypropyl Starch ( Hydroxypropyl Starch) may include one or more selected from the group consisting of.
또한, 상기 감자전분은 아세틸아디프산이전분(Acetylated Distarch Adipate)을 포함하는 감자 유래의 변성전분일 수 있다.In addition, the potato starch may be potato-derived modified starch containing acetylated distarch adipate.
또한, 상기 젤라틴은 강도가 150 ~ 250 Bloom일 수 있다.In addition, the gelatin may have a strength of 150 to 250 Bloom.
또한, 상기 동물성 츄어블 연질캡슐용 조성물은, 상기 감자전분 100 중량부에 대하여 물을 150 ~ 300 중량부로 더 포함할 수 있다.In addition, the animal-based chewable soft capsule composition may further include 150 to 300 parts by weight of water based on 100 parts by weight of the potato starch.
또한, 본 발명은 감자전분, 상기 감자전분 100 중량부에 대하여 아라비아검을 0.5 ~ 10 중량부 및 젤라틴을 150 ~ 270 중량부로 포함하며, 내부에 충진물을 수용하기 위한 수용부를 포함하는 동물성 츄어블 연질캡슐을 제공한다.In addition, the present invention contains potato starch, 0.5 to 10 parts by weight of gum arabic and 150 to 270 parts by weight of gelatin with respect to 100 parts by weight of the potato starch, animal chewable soft capsules containing a receptacle for accommodating a filling therein to provide.
본 발명의 일 실시예에 의하면, 상기 충진물은 약리학적 유효 성분 및 기능성 원료 중 어느 하나 이상을 포함할 수 있다.According to one embodiment of the present invention, the filler may include any one or more of pharmacologically active ingredients and functional raw materials.
본 발명의 동물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 동물성 츄어블 연질캡슐은 물 없이 섭취할 수 있으면서도, 저작감이 우수하고, 입에 넣고 씹을 때 치아에 부착하지 않을 뿐만 아니라, 피막 리본 형성성 저하에 따른 내부 충진물의 누액이나 백화현상 또는 연질캡슐 간의 부착 등의 불량이 발생하지 않는 효과가 있다.The composition for animal-based chewable soft capsules of the present invention and animal-based chewable soft capsules formed thereby can be ingested without water, have excellent chewing sensation, do not adhere to teeth when chewed in the mouth, and reduce film ribbon formation. There is an effect of not causing defects such as leakage or whitening of the inner filling according to the method or adhesion between soft capsules.
이하 본 발명의 실시예에 대하여 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 상세히 설명한다. 본 발명은 여러 가지 상이한 형태로 구현될 수 있으며 여기에서 설명하는 실시예에 한정되지 않는다.Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. This invention may be embodied in many different forms and is not limited to the embodiments set forth herein.
본 발명의 일 실시예에 따른 동물성 츄어블 연질캡슐용 조성물은, 감자전분, 아라비아검 및 젤라틴을 포함하여 구현된다.A composition for animal-based chewable soft capsules according to an embodiment of the present invention is implemented by including potato starch, gum arabic, and gelatin.
먼저, 상기 감자전분에 대하여 설명한다.First, the potato starch will be described.
상기 감자전분은 연질캡슐의 저작감이 우수하고 피막 리본 형성성 저하에 따른 내부 충진물의 누액 등의 불량이 발생하지 않도록 하는 기능을 수행한다.The potato starch has an excellent chewing sensation of the soft capsule and functions to prevent defects such as leakage of the internal filling due to a decrease in film ribbon formation.
상기 감자전분은 당업계에서 통상적으로 사용할 수 있는 천연전분 및 변성전분이라면 제한 없이 사용할 수 있으나, 바람직하게는 감자 유래의 변성전분일 수 있고, 보다 바람직하게는 산화전분(Oxidized Starch), 아세틸아디프산이전분(Acetylated Distarch Adipate), 아세틸인산이전분(Acetylated Distarch Phosphate), 옥테닐호박산나트륨전분(Starch Sodium Octenyl Succinate), 인산이전분(Distarch Phosphate), 인산일전분(Monostarch Phosphate), 인산화인산이전분(Phosphated Distarch Phosphate), 초산전분(Starch Acetate), 히드록시프로필인산이전분(Hydroxypropyl Distarch Phosphate) 및 히드록시프로필전분(Hydroxypropyl Starch)로 이루어진 군에서 선택된 1종 이상을 포함하는 감자 유래의 변성전분일 수 있으며, 더욱 바람직하게는 아세틸아디프산이전분(Acetylated Distarch Adipate)을 포함하는 감자 유래의 변성전분인 것이, 연질캡슐의 저작감이 우수하고 피막 리본 형성성 저하에 따른 내부 충진물의 누액 등의 불량이 발생하지 않도록 하는 측면에서 더욱 유리할 수 있다.The potato starch can be used without limitation as long as it is a natural starch or modified starch commonly used in the art, but it may be preferably potato-derived modified starch, more preferably oxidized starch, acetyl adip Acetylated Distarch Adipate, Acetylated Distarch Phosphate, Starch Sodium Octenyl Succinate, Distarch Phosphate, Monostarch Phosphate, Phosphated Distarch Phosphate Potato-derived modified starch containing at least one selected from the group consisting of (Phosphated Distarch Phosphate), Starch Acetate, Hydroxypropyl Distarch Phosphate, and Hydroxypropyl Starch It can be, more preferably potato-derived modified starch containing acetyladipic acid distarch adipate, the chewing sensation of the soft capsule is excellent and defects such as leakage of the internal filling due to the decrease in film ribbon formation It may be more advantageous in terms of preventing this from occurring.
다음, 상기 아라비아검에 대하여 설명한다.Next, the gum arabic will be described.
상기 아라비아검은 피막 리본 형성성 저하에 따른 내부 충진물의 누액 등의 불량 발생을 방지하는 기능을 수행한다.The gum arabic performs a function of preventing the occurrence of defects such as leakage of the inner filling material due to a decrease in film ribbon formation.
상기 아라비아검은 콩과 아라비아고무나무(Acacia senegal WILLDENOW) 또는 그 밖의 동속식물의 분비액을 건조시킨 것이나 또는 이를 탈염하여 얻어지는 것으로, 분쇄하지 않은 것은 백색-황백색의 다양한 크기를 가진 둥근 모양의 덩어리이거나 각을 가지는 조각 또는 백-황백색의 박편, 과립 또는 분말이다. It is obtained by drying the secretion of the black arabic bean and the arabic tree (Acacia senegal WILLDENOW) or other plants of the same genus or by desalting it, and the non-pulverized white-yellow white round lumps with various sizes or angles Eggplants are pieces or whitish-yellowish-white flakes, granules or powder.
한편, 본 발명에 따른 동물성 츄어블 연질캡슐용 조성물은, 상기 감자전분 100 중량부에 대하여 상기 아라비아검을 0.5 ~ 10 중량부로 포함하고, 바람직하게는 상기 아라비아검을 0.8 ~ 8.5 중량부로 포함할 수 있다. 만일 상기 감자전분 100 중량부에 대하여 상기 아라비아검이 0.5 중량부 미만이면 피막 리본 형성성 저하에 따른 내부 충진물의 누액 등의 불량이 발생할 수 있고, 상기 감자전분 100 중량부에 대하여 상기 아라비아검이 10 중량부를 초과하면 치아부착성이 증가할 수 있으며, 상대적으로 저작감이 저하되거나 불량 발생이 증가할 수 있다.Meanwhile, the composition for animal chewable soft capsules according to the present invention may include 0.5 to 10 parts by weight of the gum arabic, preferably 0.8 to 8.5 parts by weight of the gum arabic, based on 100 parts by weight of the potato starch. If the amount of gum arabic is less than 0.5 parts by weight with respect to 100 parts by weight of the potato starch, defects such as leakage of the inner filler may occur due to a decrease in film ribbon formation, and the gum arabic is 10 parts by weight with respect to 100 parts by weight of the potato starch If the weight part is exceeded, tooth adhesion may increase, and the chewing sensation may be relatively reduced or the occurrence of defects may increase.
다음, 상기 젤라틴에 대하여 설명한다.Next, the gelatin will be described.
상기 젤라틴은 피막 리본 형성성 저하에 따른 내부 충진물의 누액 등의 불량을 방지하는 기능을 수행한다.The gelatin performs a function of preventing defects such as leakage of the inner filling material due to a decrease in film ribbon formation.
상기 젤라틴은 동물의 가죽, 힘줄, 연골 등을 구성하는 천연 단백질인 콜라겐을 뜨거운 물로 처리하면 얻어지는 유도 단백질의 일종으로, 소, 돼지, 닭, 생선 등의 동물에서 유래된 것일 수 있으며, 공지된 콜라겐을 사용할 수 있음에 따라, 본 발명에서는 이를 특별히 한정하지 않는다.The gelatin is a type of induced protein obtained by treating collagen, which is a natural protein constituting animal skin, tendon, cartilage, etc., with hot water, and may be derived from animals such as cows, pigs, chickens, and fish. As it can be used, it is not particularly limited in the present invention.
한편, 상기 젤라틴은 강도가 150 ~ 250 Bloom일 수 있고, 바람직하게는 강도가 170 ~ 230 Bloom일 수 있다. 만일 상기 젤라틴의 강도가 150 Bloom 미만이면 피막 리본 형성성 저하에 따른 내부 충진물의 누액 등의 불량이 발생할 수 있고, 젤라틴의 강도가 250 Bloom을 초과하면 저작감이 저하될 수 있다.Meanwhile, the gelatin may have a strength of 150 to 250 Bloom, preferably a strength of 170 to 230 Bloom. If the strength of the gelatin is less than 150 Bloom, defects such as leakage of the inner filling may occur due to a decrease in film ribbon formation, and if the strength of the gelatin exceeds 250 Bloom, chewing sensation may be reduced.
또한, 본 발명에 따른 동물성 츄어블 연질캡슐용 조성물은, 상기 감자전분 100 중량부에 대하여 상기 젤라틴을 150 ~ 270 중량부로 포함하고, 바람직하게는 상기 젤라틴을 160 ~ 250 중량부로 포함할 수 있다. 만일 상기 감자전분 100 중량부에 대하여 상기 젤라틴이 150 중량부 미만이면 피막 리본 형성성 저하에 따른 내부 충진물의 누액 등의 불량이 발생할 수 있고, 상기 감자전분 100 중량부에 대하여 상기 젤라틴이 270 중량부를 초과하면 저작감이 저하될 수 있다.In addition, the composition for animal chewable soft capsules according to the present invention may contain 150 to 270 parts by weight of the gelatin, preferably 160 to 250 parts by weight of the gelatin, based on 100 parts by weight of the potato starch. If the amount of the gelatin is less than 150 parts by weight based on 100 parts by weight of the potato starch, defects such as leakage of the inner filler may occur due to a decrease in film ribbon formation, and 270 parts by weight of the gelatin based on 100 parts by weight of the potato starch If it is exceeded, the chewing sensation may deteriorate.
한편 본 발명의 일 실시예에 따르면, 상기 동물성 츄어블 연질캡슐용 조성물은 글리세린을 더 포함할 수 있다.Meanwhile, according to one embodiment of the present invention, the animal-based chewable soft capsule composition may further include glycerin.
상기 글리세린은 연질캡슐의 소프트함을 향상시킴으로써 저작감을 향상시키는 기능을 수행한다.The glycerin improves the softness of the soft capsule, thereby improving the chewing sensation.
본 발명에 따른 동물성 츄어블 연질캡슐용 조성물에 구비되는 젤라틴 및 글리세린은 중량비가 1 : 0.6 ~ 2.8일 수 있고, 바람직하게는 중량비가 1 : 0.8 ~ 2.3일 수 있다. 만일 상기 젤라틴 및 글리세린의 중량비가 1 : 0.6 미만이면 저작감이 저하될 수 있고, 젤라틴 및 글리세린의 중량비가 1 : 2.8을 초과하면 치아부착성이 증가할 수 있으며, 피막 리본 형성성 저하에 따른 내부 충진물의 누액 또는 연질캡슐 간의 부착 등의 불량이 발생할 수 있다.The weight ratio of gelatin and glycerin provided in the composition for animal chewable soft capsules according to the present invention may be 1:0.6 to 2.8, preferably 1:0.8 to 2.3. If the weight ratio of gelatin and glycerin is less than 1: 0.6, chewing sensation may be reduced, and if the weight ratio of gelatin and glycerin exceeds 1: 2.8, tooth adhesion may increase, and internal Defects such as leakage of filling or adhesion between soft capsules may occur.
한편, 본 발명에 따른 동물성 츄어블 연질캡슐용 조성물은, 상기 감자전분 100 중량부에 대하여 상기 글리세린을 190 ~ 400 중량부로, 바람직하게는 205 ~ 375 중량부로 포함할 수 있다. 만일 상기 감자전분 100 중량부에 대하여 상기 글리세린이 190 중량부 미만이면 저작감이 저하될 수 있고, 상기 감자전분 100 중량부에 대하여 상기 글리세린이 400 중량부를 초과하면 치아부착성이 증가할 수 있으며, 연질캡슐 간의 부착 등의 불량이 발생할 수 있다.Meanwhile, the composition for animal chewable soft capsules according to the present invention may include 190 to 400 parts by weight of the glycerin, preferably 205 to 375 parts by weight, based on 100 parts by weight of the potato starch. If the glycerin is less than 190 parts by weight with respect to 100 parts by weight of the potato starch, chewing sensation may be reduced, and if the glycerin is greater than 400 parts by weight with respect to 100 parts by weight of the potato starch, tooth adhesion may increase, Defects such as adhesion between soft capsules may occur.
한편 본 발명의 일 실시예에 따르면, 상기 동물성 츄어블 연질캡슐용 조성물은 에리스리톨을 더 포함할 수 있다.Meanwhile, according to one embodiment of the present invention, the animal-based chewable soft capsule composition may further include erythritol.
상기 에리스리톨은 연질캡슐 간의 부착 등의 불량을 방지하는 기능을 수행한다.The erythritol performs a function of preventing defects such as adhesion between soft capsules.
본 발명에 따른 동물성 츄어블 연질캡슐용 조성물은, 상기 감자전분 100 중량부에 대하여 상기 에리스리톨을 30 ~ 80 중량부로, 바람직하게는 상기 에리스리톨을 40 ~ 70 중량부로 포함할 수 있다. 만일 상기 감자전분 100 중량부에 대하여 상기 에리스리톨이 30 중량부 미만이면 연질캡슐 간의 부착 등의 불량이 발생할 수 있고, 상기 감자전분 100 중량부에 대하여 상기 에리스리톨이 80 중량부를 초과하면 백화현상 등의 불량이 발생할 수 있다.The animal chewable soft capsule composition according to the present invention may include 30 to 80 parts by weight of the erythritol, preferably 40 to 70 parts by weight, based on 100 parts by weight of the potato starch. If the erythritol is less than 30 parts by weight based on 100 parts by weight of the potato starch, defects such as adhesion between soft capsules may occur, and if the erythritol exceeds 80 parts by weight based on 100 parts by weight of the potato starch, defects such as whitening this can happen
한편 본 발명의 일 실시예에 따르면, 상기 동물성 츄어블 연질캡슐용 조성물은 물을 더 포함할 수 있다.Meanwhile, according to one embodiment of the present invention, the composition for animal-based chewable soft capsules may further contain water.
상기 물은 동물성 츄어블 연질캡슐용 조성물에 구비되는 상술한 물질들을 균일하게 분산시키는 기능을 수행한다.The water performs a function of uniformly dispersing the above-mentioned materials provided in the composition for animal chewable soft capsules.
상기 물은 상기 감자전분 100 중량부에 대하여 150 ~ 300 중량부로, 바람직하게는 170 ~ 280 중량부로 더 포함될 수 있다. 만일 상기 감자전분 100 중량부에 대하여 물이 150 중량부 미만이면 상술한 물질들의 분산성이 저하될 수 있고, 저작감이 저하될 수 있으며, 300 중량부를 초과하면 연질캡슐 제조가 매우 용이하지 않고, 제조되더라도 불량률이 현격히 높아질 수 있다.The water may be further included in 150 to 300 parts by weight, preferably 170 to 280 parts by weight, based on 100 parts by weight of the potato starch. If the amount of water is less than 150 parts by weight based on 100 parts by weight of the potato starch, the dispersibility of the above-mentioned materials and the chewing sensation may be reduced, and if it exceeds 300 parts by weight, it is not very easy to prepare soft capsules, Even if it is manufactured, the defect rate can be significantly increased.
또한, 본 발명은 상술한 동물성 츄어블 연질캡슐용 조성물을 통해 형성된 동물성 츄어블 연질캡슐을 제공한다.In addition, the present invention provides an animal-based chewable soft capsule formed through the above-described composition for animal-based chewable soft capsules.
이때, 본 발명에 따른 상기 동물성 츄어블 연질캡슐은 내부에 충진물을 수용하기 위한 수용부를 포함하며, 상기 수용부에 충진된 충진물을 포함할 수 있다.At this time, the animal-based chewable soft capsule according to the present invention includes a receiving part for accommodating a filling therein, and may include a filling filled in the containing part.
상기 충진물을 당업계에서 통상적으로 연질캡슐에 충진할 수 있는 물질이라면 제한 없이 사용할 수 있으나, 바람직하게는 약리학적 유효 성분 및 기능성 원료 중 어느 하나 이상을 포함할 수 있고, 보다 바람직하게는 비타민을 포함할 수 있으나, 이에 제한되는 것은 아니다.Any material that can be filled in soft capsules conventionally in the art can be used without limitation, but preferably includes any one or more of pharmacologically active ingredients and functional raw materials, more preferably vitamins. It can be done, but is not limited thereto.
본 발명의 동물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 동물성 츄어블 연질캡슐은 물 없이 섭취할 수 있으면서도, 저작감이 우수하고, 입에 넣고 씹을 때 치아에 부착하지 않을 뿐만 아니라, 피막 리본 형성성 저하에 따른 내부 충진물의 누액이나 백화현상 또는 연질캡슐 간의 부착 등의 불량이 발생하지 않는 효과가 있다.The composition for animal-based chewable soft capsules of the present invention and animal-based chewable soft capsules formed thereby can be ingested without water, have excellent chewing sensation, do not adhere to teeth when chewed in the mouth, and reduce film ribbon formation. There is an effect of not causing defects such as leakage or whitening of the inner filling according to the method or adhesion between soft capsules.
하기의 실시예를 통하여 본 발명을 더욱 구체적으로 설명하기로 하지만, 하기 실시예가 본 발명의 범위를 제한하는 것은 아니며, 이는 본 발명의 이해를 돕기 위한 것으로 해석되어야 할 것이다.Although the present invention will be described in more detail through the following examples, the following examples are not intended to limit the scope of the present invention, which should be interpreted to aid understanding of the present invention.
<실시예 1><Example 1>
먼저, 감자전분으로 아세틸아디프산이전분(Acetylated Distarch Adipate)을 포함하는 감자 유래의 변성전분 100 중량부에 대하여, 에리스리톨 55 중량부, 아라비아검 5 중량부 및 물 233 중량부를 혼합하여 제1혼합물을 제조하였다. 그리고, 제1혼합물에 상기 감자전분 100 중량부에 대하여 글리세린을 300 중량부 투입하여 10분 동안 혼합한 후, 온도 80℃로 가열 혼합하여 감자전분을 호화시켜서 제2혼합물을 제조하였다. 그 후, 상기 제2혼합물에 상기 감자전분 100 중량부에 대하여 강도가 200 Bloom인 젤라틴 210 중량부를 투입하여 진공 탈기시킨 후 온도 80℃에서 30분 동안 혼합하고 제3혼합물을 제조하고 진공탈기 시켜서 동물성 츄어블 연질캡슐용 조성물을 제조하였다.First, a first mixture was prepared by mixing 55 parts by weight of erythritol, 5 parts by weight of gum arabic, and 233 parts by weight of water with respect to 100 parts by weight of potato-derived modified starch containing Acetylated Distarch Adipate as potato starch. manufactured. In addition, 300 parts by weight of glycerin was added to the first mixture based on 100 parts by weight of the potato starch, mixed for 10 minutes, and heated and mixed at a temperature of 80 ° C to gelatinize the potato starch to prepare a second mixture. Then, 210 parts by weight of gelatin having a strength of 200 Bloom was added to the second mixture with respect to 100 parts by weight of the potato starch, vacuum degassed, and then mixed at a temperature of 80 ° C for 30 minutes, and a third mixture was prepared and vacuum degassed to obtain animal A composition for chewable soft capsules was prepared.
이후, 로터리다이 연질캡슐 충전기로 동물성 츄어블 연질캡슐용 조성물을 통해 동물성 츄어블 연질캡슐을 제조하였다.Thereafter, animal chewable soft capsules were prepared using the composition for animal chewable soft capsules using a rotary die soft capsule filling machine.
이때, 로터리다이 연질캡슐 충전기는 동물성 츄어블 연질캡슐용 조성물을 연질캡슐 충전기에 부착된 스프레더박스를 통해 회전하는 캐스팅드럼(Casting Drum)에 전달하여 얇은 피막시트를 형성시키고, 양방향에서 만들어진 피막시트를 한 쌍의 다이롤에 통과시켜 캡슐 형상으로 접착하는 방법을 사용하는 기기로, 연질캡슐의 성형과 연질캡슐 내용물의 충전이 동시에 실시되는 방식이다.At this time, the rotary die soft capsule filling machine transfers the composition for animal-based chewable soft capsules to a rotating casting drum through a spreader box attached to the soft capsule filling machine to form a thin film sheet, and the film sheet made in both directions is one It is a device that uses a method of bonding into a capsule shape by passing it through a pair of die rolls, and it is a method in which the formation of soft capsules and the filling of soft capsule contents are carried out at the same time.
구체적으로, 상기 제조된 동물성 츄어블 연질캡슐용 조성물을 20℃이하로 냉각된 한 쌍의 캐스팅드럼에 전달한 후, 이를 닫는 즉시 탄성이 있는 한 쌍의 얇은 피막시트가 형성되었으며, 형성된 피막시트는 연질캡슐 성형기의 이송롤러를 통과하여 상부에 배치되어 있는 인젝션 웨찌 및 다이 롤러를 통과시켰다.Specifically, after the above-prepared composition for animal-based chewable soft capsules was delivered to a pair of casting drums cooled to 20° C. or lower, a pair of elastic thin film sheets were formed as soon as they were closed, and the formed film sheets formed soft capsules After passing through the conveying roller of the molding machine, it passed through the injection wedge and die roller disposed at the top.
또한, 연질캡슐 충전기는 한 쌍의 캐스팅드럼과 스프레더박스가 설치되어 있음에 따라, 양쪽에서 만들어진 각각의 리본이 겹쳐져서 두 개의 다이 롤러 사이를 지나가게 하였고, 다이 롤러에 만들어진 한 쌍의 회전하는 금형에 통과하는 시점에서 인젝션 웨찌의 온도는 약 36℃로 가열되었으며, 다이 롤러의 압력과 온도에 의해서 연질캡슐이 완전히 접착됨으로써 동물성 츄어블 연질캡슐을 제조하였다. 이때, 연질캡슐이 접착되기 직전 인젝션 웨찌를 통과한 일정양의 충진물이 하단이 봉합된 연질캡슐에 인젝션되고, 즉시 상단이 봉합됨으로써 내부에 충진물이 수용되도록 동물성 츄어블 연질캡슐을 제조하였다.In addition, as a pair of casting drums and spreader boxes are installed in the soft capsule filling machine, each ribbon made on both sides overlaps and passes between the two die rollers, and a pair of rotating molds made on the die rollers At the time of passing through the injection wedge, the temperature of the injection wedge was heated to about 36° C., and the soft capsules were completely adhered by the pressure and temperature of the die roller, thereby preparing animal-based chewable soft capsules. At this time, a certain amount of filler passed through the injection wedge immediately before the soft capsule was attached was injected into the soft capsule sealed at the bottom, and immediately sealed at the top, thereby preparing animal-based chewable soft capsules to accommodate the filler therein.
<실시예 2 ~ 17 및 비교예 1 ~ 7> <Examples 2 to 17 and Comparative Examples 1 to 7>
실시예 1과 동일하게 실시하여 제조하되, 아라비아검, 젤라틴, 글리세린, 에라스리톨의 함량 및 포함여부 등을 변경하여 표 1 내지 표 4과 같은 동물성 츄어블 연질캡슐을 제조하였다.Animal chewable soft capsules as shown in Tables 1 to 4 were prepared in the same manner as in Example 1, except that the content and presence of gum arabic, gelatin, glycerin, and erasritol were changed.
<실험예><Experimental example>
실시예 및 비교예에서 제조된 동물성 츄어블 연질캡슐에 대하여 하기의 물성을 평가하여 하기 표 1 내지 표 4에 나타내었다.The following physical properties of the animal chewable soft capsules prepared in Examples and Comparative Examples were evaluated and are shown in Tables 1 to 4 below.
1. 저작감 평가1. Evaluation of authorship
상기 실시예 및 비교예에 따른 동물성 츄어블 연질캡슐에 대하여 100명의 훈련된 관능평가요원이 각각 시식하도록 하여, 7점법에 의한 쫀득함, 찰진 식감 및 질김을 복합적으로 평가하여 저작감을 평가하였다(1-매우 나쁘다, 2-나쁘다, 3-약간 나쁘다, 4-보통이다, 5-약간 좋다, 6-좋다, 7-매우 좋다).The animal chewable soft capsules according to the above Examples and Comparative Examples were tasted by 100 trained sensory evaluation personnel, and chewiness, chewy texture, and toughness were evaluated by a 7-point method to evaluate chewing sensation (1-very good). bad, 2 - bad, 3 - moderately bad, 4 - average, 5 - moderately good, 6 - good, 7 - very good).
2. 치아부착성 평가2. Evaluation of tooth adhesion
상기 실시예 및 비교예에 따른 동물성 츄어블 연질캡슐에 대하여 100명의 훈련된 관능평가요원이 각각 시식하도록 하여, 연질캡슐을 입에 넣고 씹을 때 치아에 부착되는 정도를 평가하여, 7점법으로 평가하였다(1-매우 나쁘다, 2-나쁘다, 3-약간 나쁘다, 4-보통이다, 5-약간 좋다, 6-좋다, 7-매우 좋다). 이때, 점수가 1점에 가까울수록 연질캡슐이 치아에 과도하게 부착되는 것을 나타내며, 점수가 7점에 가까울수록 연질캡슐이 치아에 부착되지 않고 깔끔하게 씹히는 것을 나타낸다.100 trained sensory evaluation personnel each tasted the animal-based chewable soft capsules according to Examples and Comparative Examples, and evaluated the degree of attachment to the teeth when chewing the soft capsules in the mouth, and evaluated using the 7-point method ( 1-very bad, 2-poor, 3-slightly bad, 4-average, 5-slightly good, 6-good, 7-very good). At this time, the closer the score is to 1, the soft capsules are excessively attached to the teeth, and the closer the score is to 7, the softer capsules are not attached to the teeth and chewed neatly.
3. 불량 평가3. Poor evaluation
실시예 및 비교예에 따라 제조된 동물성 츄어블 연질캡슐에 대하여, 각각의 실시예 및 비교예에 따른 동물성 츄어블 연질캡슐을 100개씩 제조하여 불량을 평가하였다.With respect to the animal-based chewable soft capsules prepared according to Examples and Comparative Examples, 100 animal-based chewable soft capsules according to each Example and Comparative Example were prepared and evaluated for defects.
구체적으로, 제조된 100개의 동물성 츄어블 연질캡슐에 피막형성성 저하에 따른 내부충진물 누액, 백화현상 및 연질캡슐 간의 부착 등의 문제 중 어떠한 이상이라도 발생하는 경우가 10개 미만인 경우 - ○, 피막형성성 저하에 따른 내부충진물 누액, 백화현상 및 연질캡슐 간의 부착 등의 문제 중 어떠한 이상이라도 발생하는 경우가 10개 이상 30개 미만인 경우 - △, 피막형성성 저하에 따른 내부충진물 누액, 백화현상 및 연질캡슐 간의 부착 등의 문제 중 어떠한 이상이라도 발생하는 경우가 30개 이상인 경우 - ×로 하여 불량을 평가하였다.Specifically, if there are less than 10 cases where any abnormalities such as internal filler leakage, whitening, and adhesion between soft capsules occur due to reduced film formation in 100 manufactured animal chewable soft capsules - ○, film formation If there are more than 10 cases and less than 30 problems such as leakage of internal filler due to degradation, whitening, and adhesion between soft capsules - △, leakage of internal filler due to decrease in film formation, whitening, and soft capsule When there were 30 or more cases in which any abnormality among problems such as adhesion to the liver occurred, defects were evaluated as - ×.
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상기 표 1 내지 표 4에서 알 수 있듯이, 본 발명에 따른 아라비아검, 젤라틴, 글리세린, 에라스리톨의 함량 및 포함여부 등을 모두 만족하는 실시예 1 ~ 실시예 5, 실시예 7, 실시예 8, 실시예 11, 실시예 12, 실시예 15 및 실시예 16이, 이 중에서 하나라도 누락된 실시예 6, 실시예 9, 실시예 10, 실시예 13, 실시예 14, 실시예 17 및 비교예 1 ~ 7에 비하여 저작감이 우수하고, 치아부착성이 적으며, 불량이 발생하지 않는 효과를 모두 동시에 발현한다는 것을 확인할 수 있다.As can be seen from Tables 1 to 4, Examples 1 to 5, Example 7, and Example 8 satisfying all of the content and inclusion of gum arabic, gelatin, glycerin, and erasritol according to the present invention , Example 11, Example 12, Example 15, and Example 16, Example 6, Example 9, Example 10, Example 13, Example 14, Example 17, and Comparative Example, in which any one of them is omitted. Compared to 1 to 7, it can be confirmed that the chewing feeling is excellent, the tooth adhesion is low, and the effects of not causing defects are all expressed at the same time.
이상에서 본 발명의 일 실시 예에 대하여 설명하였으나, 본 발명의 사상은 본 명세서에 제시되는 실시 예에 제한되지 아니하며, 본 발명의 사상을 이해하는 당업자는 동일한 사상의 범위 내에서, 구성요소의 부가, 변경, 삭제, 추가 등에 의해서 다른 실시 예를 용이하게 제안할 수 있을 것이나, 이 또한 본 발명의 사상범위 내에 든다고 할 것이다.Although one embodiment of the present invention has been described above, the spirit of the present invention is not limited to the embodiments presented herein, and those skilled in the art who understand the spirit of the present invention may add elements within the scope of the same spirit. However, other embodiments can be easily proposed by means of changes, deletions, additions, etc., but these will also fall within the scope of the present invention.
Claims (6)
상기 감자전분은 아세틸아디프산이전분(Acetylated Distarch Adipate)을 포함하는 감자 유래의 변성전분인 동물성 츄어블 연질캡슐의 피막시트용 조성물.According to claim 1,
The potato starch is a composition for film sheet of animal chewable soft capsules, which is a modified starch derived from potato containing acetylated distarch adipate.
상기 젤라틴은 강도가 150 ~ 250 Bloom인 동물성 츄어블 연질캡슐의 피막시트용 조성물.According to claim 1,
The gelatin is a composition for a film sheet of an animal chewable soft capsule having a strength of 150 to 250 Bloom.
상기 피막시트는 감자전분 100 중량부에 대하여 아라비아검 0.8 ~ 8.5 중량부, 젤라틴 160 ~ 250 중량부, 글리세린 190 ~ 400 중량부 및 에리스리톨 40 ~ 70중량부로 이루어지는, 동물성 츄어블 연질캡슐.A pair of film sheets including a filler containing at least one of a pharmacologically active ingredient and a functional raw material and a receiving portion for accommodating the filler therein,
The film sheet is composed of 0.8 to 8.5 parts by weight of gum arabic, 160 to 250 parts by weight of gelatin, 190 to 400 parts by weight of glycerin, and 40 to 70 parts by weight of erythritol based on 100 parts by weight of potato starch.
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| KR20090116897A (en) * | 2008-05-08 | 2009-11-12 | 주식회사 서흥캅셀 | Chewable soft gelatin capsule with shell blooming |
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| WO2005058242A2 (en) | 2003-12-17 | 2005-06-30 | R.P.Scherer Technologies, Inc. | Chewable soft capsules containing ungelatinized starch |
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