KR102490474B1 - Paste for producing biodegradable electroceutical, electric device and method of manufacturing the same - Google Patents

Abstract

The present invention is a biodegradable electronic medicine manufacturing paste that can implement light, thin, short and small by integrating electronic circuits, and can simply and easily implement the manufacture of electronic medicine that is decomposed in the body after a certain period of time and does not require additional surgery. It is to provide a formed biodegradable electronic device and a manufacturing method thereof. According to one embodiment of the present invention, the biodegradable electronic pharmaceutical preparation paste, a functional inorganic powder that provides conductivity, semiconductor, dielectric, or insulating; humectants; matrix polymer; and an organic solvent;

Description

Paste for producing biodegradable electroceutical, electric device and method of manufacturing the same}

The technical idea of the present invention relates to an electronic drug, and more particularly, to a biodegradable electronic drug manufacturing paste that is self-degradable in the body, a biodegradable electronic device formed using the same, and a manufacturing method thereof.

In recent years, life expectancy has increased and medical technology has been remarkably developed. In particular, research on new electronic medicines is increasing. Electroceutical is a compound word of electronic and pharmaceutical, and can generate therapeutic effects by controlling nerve functions using electrical energy. Since conventional drugs flow along blood vessels, there is a risk of side effects in areas where treatment is not desired, but electronic drugs are relatively safe because they select a specific area requiring treatment.

Conventional electronic medicines or nerve stimulators have the following limitations. First, it is made of a semi-permanent material and requires additional surgery to remove it from the human body after treatment is completed. Second, it has a complex wiring configuration for electronic circuit configuration, which causes great inconvenience when inserted into the human body. Third, complex in the body. Manufacturing of electronic devices corresponding to one shape is complicated and there is a risk of functional deterioration. Fourth, a wide invasion space is required by electrodes and nerve stimulators disposed in the body.

US Patent Publication No. 2018/0305569

The technical problem to be achieved by the technical idea of the present invention is to overcome the above-mentioned limitations, to implement a light, thin and small device by integrating an electronic circuit, and to manufacture an electronic medicine that is decomposed in the body after a certain period of time and does not require additional surgery. It is to provide a paste for preparing biodegradable electronic medicines that can be simply and easily implemented.

A technical problem to be achieved by the technical idea of the present invention is to provide a biodegradable electronic device formed using the biodegradable electronic pharmaceutical manufacturing paste and a manufacturing method thereof.

However, these tasks are exemplary, and the technical spirit of the present invention is not limited thereto.

According to one aspect of the present invention, a paste for preparing a biodegradable electronic medicine, a biodegradable electronic device, and a method for manufacturing the same, which can simply and easily manufacture the electronic medicine, are provided.

In one embodiment of the present invention, the biodegradable paste for preparing electronic medicine may include a functional inorganic powder providing conductivity, semiconductivity, dielectricity, or insulation; humectants; matrix polymer; And an organic solvent; may include.

According to one embodiment of the present invention, the functional inorganic powder provides a conductive function, and the functional inorganic powder is magnesium (Mg), iron (Fe), zinc (Zn), molybdenum (Mo), tungsten (W) , calcium (Ca), potassium (K), sodium (Na), silicon (Si), a-IGZO, germanium (Ge), and may include one or more selected from the group consisting of alloys thereof.

According to one embodiment of the present invention, the functional inorganic powder provides a conductive function, and the volume fraction of the functional inorganic powder with respect to the total volume of the paste may be in the range of 0.35 to 0.41.

According to one embodiment of the present invention, the functional inorganic powder provides a conductive function, and the biodegradable electronic pharmaceutical preparation paste includes: the functional inorganic powder in the range of 1 g to 15 g, based on 1 ml of the organic solvent; said humectant in the range of 0.1 ml to 1 ml; and an organic solvent containing the matrix polymer in the range of 0.05 g to 1 g.

According to one embodiment of the present invention, the functional inorganic powder provides a semiconductor function, and the functional inorganic powder includes silicon (Si), germanium (Ge), zinc oxide (ZnO), and aluminum-doped zinc oxide ( AZO) may include one or more selected from the group consisting of.

According to one embodiment of the present invention, the functional inorganic powder provides a semiconductor function, and the volume fraction of the functional inorganic powder with respect to the total volume of the paste may be in the range of 0.17 to 0.23.

According to one embodiment of the present invention, the functional inorganic powder provides a semiconductor function, and the biodegradable paste for preparing electronic medicine comprises: the functional inorganic powder in a range of 1 g to 5 g, based on 1 ml of the organic solvent; said humectant in the range of 0.1 ml to 1 ml; And it may include the matrix polymer in the range of 0.05 g to 1 g.

According to one embodiment of the present invention, the functional inorganic powder provides a dielectric function or an insulating function, and the functional inorganic powder includes magnesium oxide, iron oxide, zinc oxide, molybdenum oxide, tungsten oxide, calcium oxide, and potassium oxide. , sodium oxide, silicon oxide, germanium oxide, magnesium nitride, iron nitride, zinc nitride, molybdenum nitride, tungsten nitride, calcium nitride, potassium nitride, sodium nitride, silicon nitride, germanium nitride, and one selected from the group consisting of a-IGZO may contain more than

According to one embodiment of the present invention, the functional inorganic powder provides a dielectric function or an insulating function, and the volume fraction of the functional inorganic powder with respect to the total volume of the paste may be in the range of 0.05 to 0.08.

According to one embodiment of the present invention, the functional inorganic powder provides a dielectric function or an insulating function, and the biodegradable electronic medicine manufacturing paste is prepared in an amount of 0.1 g to 2 g of the functional paste, based on 1 ml of the organic solvent. inorganic powder; said humectant in the range of 0.1 ml to 1 ml; And it may include the matrix polymer in the range of 0.05 g to 1 g.

According to an embodiment of the present invention, the wetting agent is tetraglycol (Tetraglycol, TG), ethylene glycol, and N-methyl-2-pyrrolidone (N-Methyl-2-pyrrolidone, NMP). It may include one or more selected from the group consisting of.

According to one embodiment of the present invention, the matrix polymer is polycaprolactone (Polycaprolactone, PCL), silk fibroin, sodium carboxymethyl cellulose (Na-CMC), polyvinyl alcohol , PVA), polyvinyl pyrrolidone (PVP), poly lactic-co-glycolic acid (PLGA), poly lactic acid (PLA), polyglycerol It may include at least one selected from the group consisting of polyglycerol sebacate (PGS) and polybutylene adipate terephthalate (PBAT).

According to an embodiment of the present invention, the organic solvent is tetrahydrofuran (THF), dichloromethane (DCM), chloroform, dimethylformamide (DMF), acetone, And it may include one or more selected from the group consisting of ethyl acetate (ethylacetate).

According to an embodiment of the present invention, the biodegradable paste for preparing electronic drugs has a viscosity in the range of 50 Pa s to 1000 Pa s at a shear rate in the range of 1 s ^-1 to 100 / s ^-1 , and 0.01% With respect to a shear strain in the range of 10% to 10%, it may have a yield shear stress in the range of 10 ² Pa to 10 ³ Pa.

According to one embodiment of the present invention, at least one of the functional inorganic powder, the wetting agent, the matrix polymer, and the organic solvent may be composed of a biodegradable material that is degraded in vivo.

According to an embodiment of the present invention, as a method for manufacturing a biodegradable electronic device using a paste for preparing a biodegradable electronic medicine, the method for manufacturing the biodegradable electronic device has at least one of conductivity, semiconductivity, dielectricity, and insulation. providing the paste for preparing the biodegradable electronic medicine comprising; forming an electronic device structure using the biodegradable electronic pharmaceutical paste; and forming a biodegradable electronic device by sintering the electronic device structure to provide conductivity.

According to one embodiment of the present invention, the step of providing the paste for preparing biodegradable electronic medicine may include a functional inorganic powder providing conductivity, semiconductivity, dielectricity, or insulation; humectants; matrix polymer; and forming the paste for preparing the biodegradable electronic medicine by mixing the organic solvent according to the above-described ratio.

According to an embodiment of the present invention, the forming of the electronic device structure may be performed by 3D printing the paste for preparing the biodegradable electronic medicine.

According to an embodiment of the present invention, the forming of the biodegradable electronic device may be performed by heat treatment, light irradiation treatment, chemical treatment, or sintering by electrochemical treatment.

According to an embodiment of the present invention, a biodegradable electronic device formed using the above-described method for manufacturing a biodegradable electronic device, wherein the biodegradable electronic device includes a diode device, a capacitor device, an inductor device, a resistor device, and a transistor device. , an electrode element, a rectification element, a switching element, a memory element, a power storage element, and a vibration element.

According to the technical idea of the present invention, the biodegradable electronic medicine manufacturing paste is a paste that provides conductivity, semiconductor, dielectric, or insulation to form a biodegradable structure using a 3-dimensional printing method, and sintering it to improve conductivity By adding, biodegradable electronic devices and biodegradable electronic medicines can be simply and easily manufactured.

A biodegradable electronic medicine formed using the paste for preparing a biodegradable electronic medicine can overcome the limitations of conventional implantable electronic medicine. Conventional implantable electronic medicines require removal of the body after use due to the use of permanent materials, the need for complex wiring connections between electronic devices, the need to manufacture electronic devices according to the complex shape of the body, and the efficient use of space in the body for placement of electrodes and devices There are limitations such as the need for use. Therefore, the biodegradable electronic medicine according to the technical idea of the present invention is composed of biodegradable materials, which induces natural extinction after use, and is manufactured using a 3D printer method, thereby simplifying the complex shape and configuration and manufacturing method. It can be done simply.

The effects of the present invention described above have been described by way of example, and the scope of the present invention is not limited by these effects.

1 is a schematic diagram showing a biodegradable electronic medicine formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
2 is a graph showing viscosity versus shear rate of a biodegradable electronic pharmaceutical paste according to an embodiment of the present invention.
3 is a graph showing the modulus of elasticity against shear stress of a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
Figure 4 is a schematic diagram showing the sintering principle of the conductive structure formed by using a biodegradable electronic pharmaceutical manufacturing paste according to an embodiment of the present invention.
5 are scanning electron microscope images showing microstructures before and after sintering of a conductive structure formed using a biodegradable electronic pharmaceutical paste according to an embodiment of the present invention.
Figure 6 is a graph showing the change in resistance according to the sintering time of the conductive structure formed using the biodegradable electronic pharmaceutical manufacturing paste according to an embodiment of the present invention.
7 are photographs showing a linear structure formed using a biodegradable electronic medicine manufacturing paste according to an embodiment of the present invention.
8 is a flowchart illustrating a method of manufacturing a biodegradable electronic device manufactured using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
9 is a photograph showing various biodegradable electronic devices formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
10 is a graph showing the resistance value versus the length of a resistance element, which is a biodegradable electronic element formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
11 is a graph showing the capacitance value versus the number of layers of a capacitor element, which is a biodegradable electronic element formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
12 is a graph showing the inductance value versus the number of layers of an inductor element, which is a biodegradable electronic element formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
13 is a graph showing rectification characteristics of a diode device, which is a biodegradable electronic device formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
14 is a photograph showing a transistor element, which is a biodegradable electronic element, formed using a biodegradable electronic medicine manufacturing paste according to an embodiment of the present invention.
15 is a graph showing a change in drain current versus drain voltage of a transistor element, which is a biodegradable electronic element formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
16 is a schematic diagram illustrating a biodegradable electronic device or a 3D printing device for manufacturing a biodegradable electronic device using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.
17 are photographs showing a laminated structure formed by using a 3D printing device with a biodegradable electronic pharmaceutical paste according to an embodiment of the present invention.
18 are photographs showing a 3D biodegradable electronic medicine obtained by using a 3D printing device to form a biodegradable electronic medicine paste according to an embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. The embodiments of the present invention are provided to more completely explain the technical idea of the present invention to those skilled in the art, and the following examples may be modified in many different forms, The scope of the technical idea is not limited to the following examples. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the spirit of the invention to those skilled in the art. Like reference numerals throughout this specification mean like elements. Further, various elements and areas in the drawings are schematically drawn. Therefore, the technical spirit of the present invention is not limited by the relative size or spacing drawn in the accompanying drawings.

Electronic drugs, unlike general medicines made of chemical substances, refer to medical devices that generate a drug-like effect on the human body by stimulating the central peripheral nervous system using electronic devices that generate electrical signals. The range to which the electronic medicine can be applied may include all diseases for which treatment using electrical stimulation is possible, for example, chronic intractable diseases such as diabetes, asthma, chronic airway obstruction, arthritis, high blood pressure, gastrointestinal disorder, and the like. The electronic medicine is classified into a non-wearable type (grade 1), a wearable type (grade 2), and an insertion type (grade 3 and 4). In the United States, Europe, etc., licenses and success cases for these electronic medicines are increasing, and continuous investment is being made.

The technical idea of the present invention is to provide a biodegradable electronic medicine manufacturing paste that can easily and simply manufacture the electronic medicine, is capable of three-dimensional printing, and can be biodegraded in the human body.

The paste for preparing biodegradable electronic medicine according to the technical concept of the present invention may provide conductivity, semiconductivity, dielectricity, or insulation, depending on the purpose. A biodegradable electronic device may be formed using a method such as lamination using the paste for preparing a biodegradable electronic medicine. The biodegradable electronic device may include, for example, an active device or a passive device, and may include, for example, a diode device, a capacitor device and an inductor device, a resistance device, a transistor device, an electrode device, a rectification device, a switching device, and a memory device. , a power storage element, a vibration element, and the like can be formed, and furthermore, an integrated circuit can be formed. The biodegradable electronic device may be activated through post-processing such as heat treatment, sintering, and drying.

By manufacturing a biodegradable electronic medicine using the biodegradable electronic medicine manufacturing paste according to the technical idea of the present invention, the biodegradable electronic device can be applied to the medical device industry, such as a patient-customized implantable neuroelectric stimulator. Furthermore, the technology related to the biodegradable electronic device can be used in various fields such as food industry such as food packaging, smart farm industry such as soil/plant/illuminance sensor, and fashion clothing industry.

1 is a schematic diagram showing a biodegradable electronic drug 100 formed using a paste for preparing a biodegradable electronic drug according to an embodiment of the present invention.

Referring to FIG. 1, the biodegradable electronic medicine 100 has a through hollow part 190 therein. A treatment target nerve cell (NC) requiring treatment may be inserted into the penetrating hollow part 190 . For example, nodes of nerve cells (NC) to be treated in the cut or damaged region (CR) to be treated may be respectively inserted from the upper and lower sides of the through-hole 190 and connected to each other. Subsequently, the biodegradable electronic device provided in the biodegradable electronic device 100 transmits an electrical signal to the target nerve cell (NC), thereby bonding and treating the target nerve cell (NC). In addition, the biodegradable electronic drug 100 may be formed as a biodegradable or biodegradable material, and thus may be decomposed and absorbed in the human body after treatment is finished or after a certain period of time, and thus does not require a separate removal operation. will not be

A paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention includes functional inorganic powder; humectants; matrix polymer; and an organic solvent; The paste for preparing the biodegradable electronic medicine includes a mixture of the above materials. The biodegradable electronic medicine manufacturing paste may be implemented in a form having fluidity, and may be implemented in various forms such as liquid, suspension, sol, gel, and the like.

At least one of the functional inorganic powder, the wetting agent, the matrix polymer, and the organic solvent may be composed of a biodegradable material that is degraded in vivo. The meaning of the biodegradable means a material that can be absorbed in the human body and is harmless after absorption.

The functional inorganic powder may provide different functions depending on the material it contains, and may provide, for example, conductivity, semiconductivity, dielectricity, or insulation.

When the functional inorganic powder provides a conductive function, the functional inorganic powder may include a conductive material. The functional inorganic powder may be, for example, magnesium (Mg), iron (Fe), zinc (Zn), molybdenum (Mo), tungsten (W), calcium (Ca), potassium (K), sodium (Na), silicon It may include one or more selected from the group consisting of (Si), a-IGZO, germanium (Ge), and alloys thereof.

In the paste for preparing biodegradable electronic medicine, when the functional inorganic powder provides a conductive function, the volume fraction of the functional inorganic powder relative to the total volume of the paste may be, for example, in the range of 0.35 to 0.41. The volume fraction of the functional inorganic powder may vary depending on the size of the functional inorganic powder, and for example, the above-described volume fraction is such that the functional inorganic powder having conductivity has a size of 10 μm or less, for example, For example, it can be derived from a size ranging from 0.5 μm to 10 μm.

In addition, when the functional inorganic powder provides a conductive function, the biodegradable electronic pharmaceutical manufacturing paste may include, for example, the functional inorganic powder in the range of 1 g to 15 g based on 1 ml of the organic solvent; said humectant in the range of 0.1 ml to 1 ml; and 0.05 g to 1 g of the matrix polymer.

When the functional inorganic powder provides a semiconductor function, the functional inorganic powder may include a semiconductor material. The functional inorganic powder may include, for example, at least one selected from the group consisting of silicon (Si), germanium (Ge), zinc oxide (ZnO), and aluminum-doped zinc oxide (AZO). When the functional inorganic powder provides a semiconducting function, it may have p-type or n-type characteristics by doping.

In the paste for preparing biodegradable electronic medicine, when the functional inorganic powder provides a semiconductor function, the volume fraction of the functional inorganic powder relative to the total volume of the paste may be, for example, in the range of 0.17 to 0.23. The volume fraction of the functional inorganic powder may change depending on the size of the functional inorganic powder, and for example, the above-mentioned functional inorganic powder having a semiconducting property has a size of 400 nm or less, for example, For example, it may be derived from a size ranging from 200 nm to 400 nm.

In addition, when the functional inorganic powder provides a semiconductor function, the biodegradable electronic pharmaceutical manufacturing paste may include, for example, the functional inorganic powder in the range of 1 g to 5 g based on 1 ml of the organic solvent; said humectant in the range of 0.1 ml to 1 ml; and 0.05 g to 1 g of the matrix polymer.

When the functional inorganic powder provides a dielectric function or an insulating function, the functional inorganic powder may include a dielectric material or an insulating material. The functional inorganic powder, for example, magnesium oxide, iron oxide, zinc oxide, molybdenum oxide, tungsten oxide, calcium oxide, potassium oxide, sodium oxide, silicon oxide, germanium oxide, magnesium nitride, iron nitride, zinc nitride, molybdenum nitride, tungsten nitride, calcium nitride, potassium nitride, It may include at least one selected from the group consisting of sodium nitride, silicon nitride, germanium nitride, and a-IGZO For example, the functional inorganic powder may include SiO ₂ , MgO, Si ₃ N ₄ , etc. .

In the biodegradable electronic medicine manufacturing paste, when the functional inorganic powder provides a dielectric function or an insulating function, the volume fraction of the functional inorganic powder relative to the total volume of the paste is, for example, in the range of 0.05 to 0.08. can The volume fraction of the functional inorganic powder may vary depending on the size of the functional inorganic powder, and for example, the above-described functional inorganic powder having dielectric or insulating properties may have a size of 40 nm or less, for example, For example, it can be derived from a size ranging from 30 nm to 40 nm.

In addition, when the functional inorganic powder provides a dielectric function or an insulating function, the biodegradable electronic medicine manufacturing paste is, for example, based on 1 ml of the organic solvent, the functional inorganic powder in the range of 0.1 g to 2 g. ; said humectant in the range of 0.1 ml to 1 ml; and 0.05 g to 1 g of the matrix polymer.

The wetting agent may perform a function of suppressing rapid evaporation of the organic solvent. For example, in the case where the wetting agent is not present, the organic solvent evaporates rapidly during printing of the paste, and thus printing may be difficult. In addition, after 3D printing, the organic solvent evaporates rapidly, resulting in severe volume change of the printed solid structure. Therefore, by including the wetting agent, unwanted solidification of the paste can be prevented, and the shape of the printed structure can be maintained without being damaged.

The wetting agent is, for example, one selected from the group consisting of tetraglycol (TG), ethylene glycol, and N-Methyl-2-pyrrolidone (NMP) may contain more than

The matrix polymer may function as a matrix material after the biodegradable electronic pharmaceutical preparation paste is changed into a solid material. The matrix polymer may have stable characteristics against heating, light irradiation, or chemical treatment.

The matrix polymer is, for example, polycaprolactone (PCL), silk fibroin, sodium carboxymethyl cellulose (Na-CMC), polyvinyl alcohol (PVA), polyvinyl Polyvinyl pyrrolidone (PVP), poly lactic-co-glycolic acid (PLGA), poly lactic acid (PLA), polyglycerol sebacate, PGS) and polybutylene adipate terephthalate (Polybutylene adipate terephthalate, PBAT).

The organic solvent may serve as a solvent for dissolving or dispersing other constituents of the paste, and may also perform a function for providing fluidity to the paste. The organic solvent may include a liquid material. The organic solvent may be removed when the paste becomes a solid state to form a biodegradable electronic device, and thus may have volatility or a relatively low vaporization temperature compared to other components. The organic solvent can be easily removed by heating, light irradiation, or chemical treatment.

The organic solvent is, for example, tetrahydrofuran (THF), dichloromethane (DCM), chloroform, dimethylformamide (DMF), acetone, and ethyl acetate (ethylacetate) It may include one or more selected from the group consisting of.

Even when the biodegradable electronic medicine manufacturing paste has other functions such as conductivity, semiconductor, dielectric, or insulating properties, the biodegradable electronic medicine manufacturing paste can be ejected by one 3D printer device, and one Since it can constitute a biodegradable electronic device of, it is preferable that the viscosity and elastic modulus are similar. The viscosity and modulus of elasticity of the biodegradable electronic medicine paste may be changed according to the volume fraction of the functional inorganic powder.

Hereinafter, the viscosity and modulus of elasticity for the shear rate of the biodegradable electronic pharmaceutical preparation paste will be reviewed. Hereinafter, zinc powder is used when the functional inorganic powder is conductive, aluminum-doped zinc oxide powder is used when the functional inorganic powder is conductive, and a mixture of silicon oxide and magnesium oxide is used when the functional inorganic powder is dielectric/insulating. However, this is exemplary and the technical spirit of the present invention is not limited thereto.

For reference, the experiments for the viscosity and the elastic modulus described below are performed with a volume fraction of the zinc powder in the range of 0.35 to 0.41, a volume fraction of the aluminum-doped zinc oxide powder in the range of 0.17 to 0.23, and a volume fraction of the aluminum-doped zinc oxide powder in the range of 0.05 to 0.08 It was performed for the volume fraction of the mixture of the silicon oxide and magnesium oxide in the range. In the above range, it only means that the volume fraction shown in FIGS. 2 and 3 can be selected as the optimal volume fraction, and other volume fractions within the described range can also be selected as the biodegradable electronic pharmaceutical preparation paste. . In addition, these volume fractions are exemplary, and the technical spirit of the present invention is not limited thereto.

2 is a graph showing viscosity versus shear rate of a biodegradable electronic pharmaceutical paste according to an embodiment of the present invention.

Referring to FIG. 2, in a shear rate range of 1 s ^-1 to 100 / s ^-1 , the volume fraction of the zinc (Zn) powder relative to the total volume of the paste is 0.38, the aluminum-doped zinc oxide ( When the volume fraction of the AZO) powder was 0.2 and the volume fraction of the mixture of silicon oxide and magnesium oxide (SiO ₂ /MgO) was 0.08, the behavior of the viscosity of the three pastes having different functions was almost similar. .

From these results, the paste for preparing the biodegradable electronic medicine may have a viscosity in the range of, for example, 50 Pa s to 1000 Pa s at a shear rate in the range of 1 s ^-1 to 100 / s ^-1 . Specifically, the paste for preparing the biodegradable electronic medicine may have a viscosity of, for example, 50 Pa s to 1000 Pa s at a shear rate of 10 s ^-1 .

3 is a graph showing the modulus of elasticity against shear stress of a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.

Referring to FIG. 3, at a shear stress in the range of 1 Pa to 1000 Pa, the volume fraction of the zinc (Zn) powder is 0.38, the volume fraction of the aluminum-doped zinc oxide (AZO) powder is 0.2, and the volume fraction of the When the volume fraction of the mixture of silicon oxide and magnesium oxide (SiO ₂ /MgO) was 0.08, the behavior of the elastic modulus of the three pastes with different functions was almost similar. The elastic modulus was calculated by measuring the shear stress after applying a shear strain in the range of 0.01% to 10%, and calculating the relationship between the shear strain and the shear stress.

From these results, the paste for preparing biodegradable electronic drugs may also have an elastic modulus in the range of, for example, 10 ² Pa to 10 ⁶ Pa with respect to shear stress in the range of 1 Pa to 1000 Pa. The biodegradable paste for preparing electronic drugs may have a modulus of elasticity in the range of, for example, 10 ² Pa to 10 ⁶ Pa, with respect to a shear strain in the range of 0.01% to 10%.

In the elastic modulus graph, yield shear stress can be calculated for a shear stress point where the elastic modulus rapidly decreases. Accordingly, the biodegradable paste for preparing electronic medicine may have a yield shear stress in the range of 10 ² Pa to 10 ³ Pa with respect to a shear strain in the range of 0.01% to 10%.

From the above results, it is possible to set an appropriate fraction of the functional inorganic powder so that the paste for preparing biodegradable electronic medicine is suitable for manufacturing a biodegradable electronic device or a biodegradable electronic device when used for 3D printing or the like. Also, fractions of other components can be accounted for. The fraction of the components is as described above.

The biodegradable electronic medicine manufacturing paste may form various biodegradable electronic devices or biodegradable electronic medicines. For example, a biodegradable electronic device may be formed by a 3D printing method using a 3D printing device described below with reference to FIG. 16 .

In order to form a biodegradable electronic device or a biodegradable electronic medicine from the paste for preparing a biodegradable electronic medicine, activation of an electrical function is required in some cases. That is, when the paste for preparing biodegradable electronic medicine has conductivity or semiconductivity, activation of electrical conductivity is required.

In the case where a conductive function is required, the paste for preparing a biodegradable electronic medicine according to the technical concept of the present invention is mixed with a conductive powder with a matrix polymer having low conductivity, so that the conductivity is lowered than that of a pure conductor. Therefore, it is necessary to increase conductivity by sintering and aggregating the conductive powder. This need is also required when performing a semiconducting function.

Various methods such as light, heat, or chemical methods may be used for the sintering. By way of example, sintering will be described in an electrochemical method.

Figure 4 is a schematic diagram showing the sintering principle of the conductive structure formed by using a biodegradable electronic pharmaceutical manufacturing paste according to an embodiment of the present invention.

Referring to FIG. 4 , after forming a conductive structure using the biodegradable electronic pharmaceutical preparation paste, the organic solvent and wetting agent included in the paste may be removed by drying. Accordingly, only the conductive functional inorganic powder 1 and the matrix polymer 2 are shown. An initial surface layer 3 may be formed on the surface of the functional inorganic powder 1 .

When the structure is treated with an acid such as acetic acid, the initial surface layer 3 is removed by combining with hydrogen ions (H ⁺ ) contained in the acid, and the functional inorganic powder 1 is exposed. In addition, a part of the inorganic powder 1 may be ionized and discharged to the outside or may be reduced again and attached to the inorganic powder 1 . The exposed functional inorganic powders 1 may be connected to each other and aggregated together. Then, when dried, the final surface layer 4 is formed on the surface of the aggregated functional inorganic powder 1. Accordingly, the functional inorganic powders 1 may form a network connected to each other, and conductivity may be increased.

Here, the initial surface layer 3 and the final surface layer 4 may be composed of, for example, an oxide layer or a hydroxide layer, for example, a zinc oxide layer (ZnO) or a zinc hydroxide layer (Zn(OH) ₂ ). It can be.

The acid treatment may be performed using an acidic solution containing various acidic substances, for example, hydrochloric acid, nitric acid, sulfuric acid, acetic acid, phosphoric acid, and the like. The acidic solution may include an acidic material and water in a ratio of, for example, 1:10 to 10:1.

The acid treatment is performed by immersing the structure formed of the biodegradable electronic medicine paste in the acidic solution for, for example, 1 minute to 60 minutes, for example, 10 minutes, followed by nitrogen gas or argon. It can be finished by drying using an inert gas such as gas.

Experimental example

Hereinafter, a preferred experimental example is presented to aid understanding of the present invention. However, the following experimental examples are only for helping understanding of the present invention, and the present invention is not limited by the following experimental examples.

Preparation of conductive paste

A paste for preparing a biodegradable electronic medicine having the conductivity was prepared with the following composition.

Functional inorganic powder: zinc powder 7.2 g;

Humectant: tetraglycol 0.5 ml;

Matrix polymer: 0.15 g of polycaprolactone; and

Organic solvent: 1 ml of tetrahydrofuran;

The above materials were mixed using revolution mixing and rotation mixing to prepare a uniformly mixed conductive paste. In the conductive paste, the volume fraction of the zinc powder with respect to the total volume of the paste was about 0.38.

Manufacture of semiconducting paste

A biodegradable electronic pharmaceutical preparation paste having the semiconductor property was prepared with the following composition.

Functional inorganic powder: 2.3 g of aluminum-doped zinc oxide powder;

Humectant: tetraglycol 0.5 ml;

Matrix polymer: 0.15 g of polycaprolactone; and

Organic solvent: 1 ml of tetrahydrofuran;

The above materials were mixed using revolution mixing and rotation mixing to prepare a uniformly mixed semiconducting paste. In the semiconducting paste, the volume fraction of the aluminum-doped zinc oxide powder relative to the total volume of the paste was about 0.2.

Manufacture of dielectric or insulating pastes

A biodegradable electronic medicine paste having the dielectric or insulating properties was prepared with the following composition.

Functional inorganic powder: silicon oxide powder 0.18 g and magnesium oxide 0.269 g;

Humectant: tetraglycol 0.5 ml;

Matrix polymer: 0.15 g of polycaprolactone; and

Organic solvent: 1 ml of tetrahydrofuran;

The above materials were mixed using static mixing and autorotation mixing to prepare a uniformly mixed dielectric or insulating paste. In the dielectric or insulating paste, the volume fraction of the silicon oxide powder with respect to the total volume of the paste was about 0.04, and the volume fraction of the magnesium oxide powder was about 0.04. Therefore, the volume fraction of their sum is 0.08.

5 are scanning electron microscope images showing microstructures before and after sintering of a conductive structure formed using a biodegradable electronic pharmaceutical paste according to an embodiment of the present invention.

Referring to FIG. 5 , the paste for preparing biodegradable electronic medicine is a case in which zinc is included as a functional inorganic powder, and thus, a conductive function can be provided. The microstructure of the conductive structure formed using the paste was observed before and after sintering.

Before sintering, spherical zinc particles have individually separated microstructures, and a connection structure between particles is hardly observed.

On the other hand, after sintering, a network structure connecting the zinc particles was observed. In addition, since the adjacent particles are closely connected to each other and formed, a sintered shape other than the original individual spherical shape was exhibited. Conductivity can be increased by this network and sintered shape. This sintering result can also be applied to a semiconductor structure.

Figure 6 is a graph showing the change in resistance according to the sintering time of the conductive structure formed using the biodegradable electronic pharmaceutical manufacturing paste according to an embodiment of the present invention.

Referring to FIG. 6, it is a result of the conductive structure of FIG. 5. Before sintering, the conductive structure exhibited a relatively high resistance value of about 0.55 Ω, which is analyzed to indicate high resistance, that is, low conductivity, because the conductive zinc particles are separated from each other and not electrically connected. When sintering proceeded, the resistance value rapidly decreased. This rapid decrease appeared in the initial time within 1 minute. It showed 0.2 Ω at 5 minutes of sintering time, and thereafter, it hardly changed even if the sintering time was increased. Therefore, the conductive structure body can provide an excellent conductive function by the above-described electrochemical sintering.

7 are photographs showing a linear structure formed using a biodegradable electronic medicine manufacturing paste according to an embodiment of the present invention.

Referring to FIG. 7 , linear structures of various sizes formed by using 3D printing from the paste for preparing biodegradable electronic medicine in which the functional inorganic powder includes zinc are shown. The linear structure may have various line width sizes according to nozzles of a 3D printer. The linear structure had, for example, a line width in the range of 150 μm to 1000 μm, and defects such as line breakage, contraction, and expansion were not found in the range, and it was formed to have significantly high uniformity.

These results were the same even when the biodegradable electronic medicine manufacturing paste had semiconductor, dielectric, or insulating properties. Therefore, the biodegradable electronic medicine manufacturing paste can be applied to a 3D printing method to manufacture a biodegradable electronic device and a biodegradable electronic device.

8 is a flowchart illustrating a method (S10) of manufacturing a biodegradable electronic device manufactured using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.

Referring to FIG. 8, the method of manufacturing a biodegradable electronic device (S10) is a method of manufacturing a biodegradable electronic device using a paste for preparing a biodegradable electronic medicine, wherein at least one of conductivity, semiconductivity, dielectricity, and insulation is used. providing the paste for preparing the biodegradable electronic medicine comprising (S11); Forming an electronic device structure using the biodegradable electronic medicine paste (S12); and forming a biodegradable electronic device by sintering the electronic device structure to provide conductivity (S13).

In the step of providing the biodegradable electronic medicine paste (S11), the biodegradable electronic medicine preparation pastes having conductivity, semiconductor, dielectric, or insulating properties are formed according to the above-described method. The biodegradable paste for preparing electronic medicine may include a functional inorganic powder providing conductivity, semiconductivity, dielectricity, or insulation; humectants; matrix polymer; and forming the paste for preparing the biodegradable electronic medicine by mixing the organic solvent according to the above-described ratio.

Forming the electronic device structure (S12) may be performed by 3D printing the paste for preparing the biodegradable electronic medicine. Specifically, the electronic device structure may be formed by discharging the biodegradable electronic medicine paste according to the design of the electronic device using a 3D printer device.

Forming the biodegradable electronic device (S13) may be performed by electrochemical sintering as described above. However, this is exemplary and the sintering may be performed by heat treatment, light irradiation treatment, chemical treatment, or electrochemical treatment.

A biodegradable electronic device formed using the method for manufacturing a biodegradable electronic device as described above, wherein the biodegradable electronic device includes a diode device, a capacitor device and an inductor device, a resistance device, a transistor device, an electrode device, a rectifier device, It may include at least one of a switching element, a memory element, a power storage element, and a vibration element.

9 is a photograph showing various biodegradable electronic devices formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.

Referring to FIG. 9 , various biodegradable electronic devices were formed using the biodegradable electronic pharmaceutical preparation paste. The biodegradable electronic device formed, for example, a resistor (5), a capacitor (6), an inductor (7), and a diode (8). The biodegradable electronic devices were used to form structures using a 3D printing method, and if necessary, conductivity could be secured by electrochemical sintering. In addition, when performing the 3D printing, the biodegradable electronic devices can be formed in one process by alternately discharging conductive paste, semiconducting paste, dielectric paste, and insulating paste using a plurality of nozzles. there was.

10 is a graph showing the resistance value versus the length of a resistance element, which is a biodegradable electronic element formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.

Referring to FIG. 10 , the resistance value increased linearly as the length of the resistance element increased. The conductivity (σ) of the resistance element was about 740 S/m. Therefore, since the resistance element can effectively perform a resistance function, the resistance element can be effectively formed using the biodegradable electronic medicine manufacturing paste.

11 is a graph showing the capacitance value versus the number of layers of a capacitor element, which is a biodegradable electronic element formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.

Referring to FIG. 11 , the capacitance value increased almost linearly as the number of layers of the capacitor element increased. Since the capacitor element can effectively perform a capacitor function, the capacitor element can be effectively formed using the biodegradable electronic medicine manufacturing paste.

12 is a graph showing the inductance value versus the number of layers of an inductor element, which is a biodegradable electronic element formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.

Referring to FIG. 12 , the inductance value increased almost linearly as the number of layers of the inductance element increased. Since the inductance element can effectively perform an inductance function, the inductance element can be effectively formed using the biodegradable electronic medicine paste.

13 is a graph showing rectification characteristics of a diode device, which is a biodegradable electronic device formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.

Referring to FIG. 13 , the current of the diode device linearly increased with an increase in voltage at a positive voltage. At negative voltage, the current was 0A. I _on /I _off of the diode device was found to be about 47.2. Since the diode element can effectively perform a rectification function, the diode element can be effectively formed using the biodegradable electronic medicine manufacturing paste.

In addition, an active device such as a transistor device may be implemented using the biodegradable electronic medicine manufacturing paste.

14 is a photograph showing a transistor element, which is a biodegradable electronic element, formed using a biodegradable electronic medicine manufacturing paste according to an embodiment of the present invention.

Referring to FIG. 14, in the transistor device, which is a biodegradable electronic device, a conductive biodegradable electronic medicine manufacturing paste was used to form a source electrode, a drain electrode, and a gate electrode made of zinc. . In addition, a channel layer (Active) composed of AZO was formed using a semiconductor biodegradable electronic medicine manufacturing paste. The transistor was formed on a dielectric material of biodegradable material agarose and NaCl gel.

15 is a graph showing a change in drain current versus drain voltage of a transistor element, which is a biodegradable electronic element formed using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.

Referring to FIG. 15 , the drain current of the transistor device increased almost linearly as the drain voltage increased. This linear increase trend was the same at various gate voltages. As the gate voltage increases, the slope becomes smaller. Since the transistor element can effectively perform a transistor function, the transistor element can be effectively formed using the biodegradable electronic medicine manufacturing paste.

Hereinafter, a 3D printing method capable of forming a biodegradable structure such as a biodegradable electronic device or a biodegradable electronic medicine using the paste for preparing a biodegradable electronic medicine will be described.

16 is a schematic diagram showing a biodegradable electronic device or a 3D printing apparatus 900 for manufacturing a biodegradable electronic device using a paste for preparing a biodegradable electronic medicine according to an embodiment of the present invention.

Referring to FIG. 16, the 3D printing device 900 includes a spinning solution tank 910, a spinning nozzle 920, a spinning nozzle tip 930, and a collector 950.

The 3D printing device 900 is a method of directly forming and stacking layers of a spinning solution 960 in a direct ink writing (DIW) method. In the direct ink writing method, when a spinning solution 960 such as ink or paste is pushed using a screw, a piston or pressure, the spinning solution 960 is discharged to the outside through a spinning nozzle 920. Subsequently, the discharged spinning solution 960 is solidified on the collector 950. When one layer is solidified, another layer of layers may then be stacked and solidified to form a three-dimensional structure. At this time, as a method of solidifying, it may be due to external stimuli such as reaction with ultraviolet rays or CaCl ₂ , or by characteristics such as rapid evaporation of the solvent or formation of an oxide layer on the surface, or by the characteristics of the spinning solution 960 itself. The biodegradable electronic medicine according to an embodiment of the present invention may use a solidification method using the self-characteristics of the spinning solution 960 by pushing the spinning solution 960 with pressure. However, this is exemplary and the technical spirit of the present invention is not limited thereto.

The spinning solution tank 910 may store the spinning solution 960. The spinning solution tank 910 may provide the spinning solution 960 to the spinning nozzle 920 by pressurizing the spinning solution 960 using a built-in pump (not shown). The spinning nozzle 920 may receive the spinning solution 960 from the spinning solution tank 910 and emit the spinning solution 960 through the spinning nozzle tip 930 located at one end. Spinning nozzle tip 930 After the spinning solution 960 is pressurized by the pump to fill the inner nozzle tube, the spinning solution 960 can be spun by the voltage applied by the power source 940. The collector 950 is a spinning nozzle It is located on the lower side of 920 and accommodates the spinning solution 960 to be spun.

The positional relationship between the collector 950 and the spinneret 920 is exemplary, and the technical spirit of the present invention is not limited thereto. For example, the case where the collector 950 is positioned above the spinning nozzle 920 and the spinning solution 960 emitted from the spinning nozzle 920 is spun upward is also included in the technical concept of the present invention. For example, a case in which the collector 950 is positioned horizontally with respect to the spinning nozzle 920 and the spinning solution 960 emitted from the spinning nozzle 920 is spun in a horizontal direction is also included in the technical concept of the present invention. The collector 950 may be located horizontally or on the same spatial axis as the spinneret 920.

Conditions for 3D printing the spinning solution 960 in a pneumatic manner are as follows. The spinning solution 960 should be discharged in the form of a filament through the spinning nozzle 920. In addition, the stacking of the layer formed of the spinning solution 960 should be easy. When the shear stress applied to the spinning solution 960 is increased, the shear modulus of the spinning solution 960 must have viscoelastic properties that are reduced while being maintained. As the shear rate of the spinning solution 960 increases, the viscosity of the spinning solution 960 should have a shear thinning characteristic that decreases.

The spinning solution 960 may vary according to a material for which spinning is desired, and may include, for example, materials constituting the above-described conductor region, insulator region, and semiconductor region, respectively. The spinning solution 960 may form ink or paste by mixing polymer and conductive particles. Therefore, the conductivity of the conductor region may be reduced compared to the case where only the pure conductor is formed.

In order to increase the conductivity of the conductor region, a conductive network of conductive particles included in the conductor region may be formed through sintering using light irradiation, heating, or a chemical reaction. For example, in the present invention, a method of sintering through an electrochemical method may be used. For example, after an oxide film formed on the surface of the conductive particles is removed using an acid, the ionized conductive atoms are reduced again, and then a conductive network between the conductive particles may be formed.

17 are photographs showing a laminated structure formed by using a 3D printing device with a biodegradable electronic pharmaceutical paste according to an embodiment of the present invention.

Referring to FIG. 17, (a) is a zinc (Zn) layered structure constituting a conductor region of a biodegradable electronic medicine, and (b) is an aluminum-doped zinc oxide (AZO) constituting a semiconductor region. It is a layered structure, and (c) is a layered structure of silicon oxide/magnesium oxide (SiO ₂ /MgO) capable of constituting an insulator region. The laminated structures are formed by stacking layers of each layer formed by irradiating from a 3D printing device. In all cases, it can be confirmed that the formation of the laminated structure is easy and there is a possibility of freely changing the shape. For reference, internal photos show examples of layers formed by radiating from a 3D printing device for each case.

18 are photographs showing a 3D biodegradable electronic medicine obtained by using a 3D printing device to form a biodegradable electronic medicine paste according to an embodiment of the present invention.

Referring to FIG. 18 , zinc (Zn) may constitute a conductor region, aluminum doped zinc oxide (AZO) may constitute a semiconductor region, and silicon oxide (SiO ₂ ) or silicon oxide may constitute an insulator region. / Biodegradable electronics stacked including magnesium oxide (SiO ₂ /MgO) and the like are shown. In the biodegradable electronic medicines, according to the manufacturing method of the present invention, it can be confirmed that the stacking of materials having different characteristics of conductors, semiconductors, and insulators is easily formed. It was confirmed that the size of the biodegradable electronic medicine can be formed in various sizes ranging from 5 mm to 15 mm in diameter. However, these sizes are exemplary, and the technical spirit of the present invention is not limited thereto.

According to the technical concept of the present invention, the biodegradable electronic medicine forms an electrical circuit as a biodegradable conductive, semiconducting, dielectric, or insulating paste through 3D printing in the medical industry, and can be embedded therein. Accordingly, it is possible to actively control a structure that can be controlled only passively by adding electronic engineering functions such as wireless communication and electrical stimulation to a simple structure. For example, an implantable biodegradable electronic medicine with built-in circuits and electrodes capable of providing electric stimulation wirelessly accelerates the healing and regeneration of cells in a living body, or forms a pressure sensor or a tension sensor in the biodegradable electronic medicine. Therefore, it is possible to open up a new field of monitoring the pressure or stress applied while inserted into the body. In addition, the biodegradable electronic medicine can be applied to biotechnology such as food and agriculture. Specifically, the biodegradable electronic medicine is an implantable medical device that accelerates peripheral nerve regeneration using a biodegradable electrical stimulator tailored to the body structure, and accelerates differentiation through electrical stimulation by putting stem cells in a biodegradable scaffold with built-in electrodes. can be done

In addition, the method of forming a biodegradable electronic medicine according to the technical idea of the present invention, specifically, the 3-dimensional stacking method using a 3-dimensional printer, etc., is applied to food smart packaging, and the sensor for measuring the internal humidity, temperature, and impact of fruit packaging etc. can be used. In addition, biodegradable electronic drugs can be applied to smart farms and used as pH, moisture, and temperature sensors in the soil and temperature, humidity, and fine dust sensors in the air.

The technical spirit of the present invention described above is not limited to the foregoing embodiments and the accompanying drawings, and various substitutions, modifications and changes are possible within the scope of the technical spirit of the present invention. It will be clear to those skilled in the art to which it pertains.

Claims (20)

functional inorganic powders that provide conductivity, semiconducting, dielectric, or insulating properties;
humectants;
matrix polymer; and
A biodegradable electronic medicine manufacturing paste for 3-dimensional printing containing an organic solvent,
The biodegradable electronic medicine manufacturing paste for 3D printing,
Has a viscosity in the range of 50 Pa s to 1000 Pa s for shear rates in the range of 1 s ^-1 to 100 s ^-1 ,
For a shear strain in the range of 0.01% to 10%, having a yield shear stress in the range of 10 ² Pa to 10 ³ Pa,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The functional inorganic powder provides a conductive function,
The functional inorganic powder is magnesium (Mg), iron (Fe), zinc (Zn), molybdenum (Mo), tungsten (W), calcium (Ca), potassium (K), sodium (Na), silicon (Si) , a-IGZO, germanium (Ge), and containing at least one selected from the group consisting of alloys thereof,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The functional inorganic powder provides a conductive function,
The volume fraction of the functional inorganic powder relative to the total volume of the paste ranges from 0.35 to 0.41,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The functional inorganic powder provides a conductive function,
The biodegradable electronic medicine manufacturing paste,
For 1 ml of the organic solvent,
said functional inorganic powder in the range of 1 g to 15 g;
said humectant in the range of 0.1 ml to 1 ml; and
Comprising the matrix polymer in the range of 0.05 g to 1 g,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The functional inorganic powder provides a semiconducting function,
The functional inorganic powder includes at least one selected from the group consisting of silicon (Si), germanium (Ge), zinc oxide (ZnO), and aluminum-doped zinc oxide (AZO).
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The functional inorganic powder provides a semiconducting function,
The volume fraction of the functional inorganic powder relative to the total volume of the paste ranges from 0.17 to 0.23,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The functional inorganic powder provides a semiconducting function,
The biodegradable electronic medicine manufacturing paste,
For 1 ml of the organic solvent,
said functional inorganic powder in the range of 1 g to 5 g;
said humectant in the range of 0.1 ml to 1 ml; and
Comprising the matrix polymer in the range of 0.05 g to 1 g,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The functional inorganic powder provides a dielectric function or an insulating function,
The functional inorganic powder may include magnesium oxide, iron oxide, zinc oxide, molybdenum oxide, tungsten oxide, calcium oxide, potassium oxide, sodium oxide, silicon oxide, germanium oxide, magnesium nitride, iron nitride, zinc nitride, molybdenum nitride, and tungsten nitride. , including at least one selected from the group consisting of calcium nitride, potassium nitride, sodium nitride, silicon nitride, germanium nitride, and a-IGZO,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The functional inorganic powder provides a dielectric function or an insulating function,
The volume fraction of the functional inorganic powder relative to the total volume of the paste ranges from 0.05 to 0.08,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The functional inorganic powder provides a dielectric function or an insulating function,
The biodegradable electronic medicine manufacturing paste,
For 1 ml of the organic solvent,
said functional inorganic powder in the range of 0.1 g to 2 g;
said humectant in the range of 0.1 ml to 1 ml; and
Comprising the matrix polymer in the range of 0.05 g to 1 g,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The humectant is
Containing at least one selected from the group consisting of tetraglycol (Tetraglycol, TG), ethylene glycol, and N-methyl-2-pyrrolidone (NMP),
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The matrix polymer,
Polycaprolactone (PCL), silk fibroin, sodium carboxymethyl cellulose (Na-CMC), polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) ), polylactic-co-glycolic acid (PLGA), polylactic acid (PLA), polyglycerol sebacate (PGS) and polybutylene adipate Containing at least one selected from the group consisting of terephthalate (Polybutylene adipate terephthalate, PBAT),
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. According to claim 1,
The organic solvent,
At least one selected from the group consisting of tetrahydrofuran (THF), dichloromethane (DCM), chloroform, dimethylformamide (DMF), acetone, and ethyl acetate including,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. delete According to claim 1,
At least one of the functional inorganic powder, the wetting agent, the matrix polymer, and the organic solvent is composed of a biodegradable material that is degraded in vivo,
Biodegradable electronic pharmaceutical manufacturing paste for 3D printing. A method for manufacturing a biodegradable electronic device using a paste for manufacturing biodegradable electronic medicine for 3D printing,
The method of manufacturing the biodegradable electronic device,
Providing a biodegradable electronic medicine manufacturing paste for 3D printing comprising at least one of conductive, semiconductive, dielectric, and insulating properties;
Forming an electronic device structure using the biodegradable electronic medicine manufacturing paste for 3D printing; and
Including; forming a biodegradable electronic device by providing conductivity by sintering the electronic device structure,
Forming the electronic device structure,
It is performed by 3-dimensional printing the biodegradable electronic medicine manufacturing paste for 3-dimensional printing,
When performing the three-dimensional printing, using a plurality of nozzles to alternately discharge conductive paste, semiconducting paste, dielectric paste, and insulating paste,
Manufacturing method of biodegradable electronic device. 17. The method of claim 16,
The step of providing a biodegradable electronic medicine manufacturing paste for 3D printing
functional inorganic powders that provide conductivity, semiconducting, dielectric, or insulating properties; humectants; matrix polymer; And mixing an organic solvent according to the above-described fraction to form a paste for preparing a biodegradable electronic medicine for 3D printing.
Manufacturing method of biodegradable electronic device. delete 17. The method of claim 16,
Forming the biodegradable electronic device,
Performed by sintering by heat treatment, light irradiation treatment, chemical treatment, or electrochemical treatment,
Manufacturing method of biodegradable electronic device. A biodegradable electronic device formed using the method of manufacturing a biodegradable electronic device according to any one of claims 16, 17 or 19,
The biodegradable electronic device,
Including at least one of a diode element, a capacitor element and an inductor element, a resistance element, a transistor element, an electrode element, a rectification element, a switching element, a memory element, a storage element, and a vibration element,
Biodegradable electronic device.

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