KR102476915B1 - 생물학적 서열의 자동화된 주석달기 및 스크리닝을 위한 시스템 및 방법 - Google Patents

생물학적 서열의 자동화된 주석달기 및 스크리닝을 위한 시스템 및 방법 Download PDF

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KR102476915B1
KR102476915B1 KR1020197000811A KR20197000811A KR102476915B1 KR 102476915 B1 KR102476915 B1 KR 102476915B1 KR 1020197000811 A KR1020197000811 A KR 1020197000811A KR 20197000811 A KR20197000811 A KR 20197000811A KR 102476915 B1 KR102476915 B1 KR 102476915B1
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제임스 디갠스
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트위스트 바이오사이언스 코포레이션
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    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
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KR1020197000811A 2016-06-10 2017-06-09 생물학적 서열의 자동화된 주석달기 및 스크리닝을 위한 시스템 및 방법 Active KR102476915B1 (ko)

Applications Claiming Priority (5)

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US201662348786P 2016-06-10 2016-06-10
US62/348,786 2016-06-10
US201662375858P 2016-08-16 2016-08-16
US62/375,858 2016-08-16
PCT/US2017/036868 WO2017214574A1 (en) 2016-06-10 2017-06-09 Systems and methods for automated annotation and screening of biological sequences

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KR20190017932A KR20190017932A (ko) 2019-02-20
KR102476915B1 true KR102476915B1 (ko) 2022-12-12

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US (1) US20170357752A1 (https=)
EP (1) EP3469499A4 (https=)
JP (2) JP2019523940A (https=)
KR (1) KR102476915B1 (https=)
CN (1) CN109564769A (https=)
CA (1) CA3027127A1 (https=)
SG (1) SG11201811025VA (https=)
WO (1) WO2017214574A1 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201600853UA (en) 2013-08-05 2016-03-30 Twist Bioscience Corp De novo synthesized gene libraries
US10669304B2 (en) 2015-02-04 2020-06-02 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3350314A4 (en) 2015-09-18 2019-02-06 Twist Bioscience Corporation OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF
KR102794025B1 (ko) 2015-09-22 2025-04-09 트위스트 바이오사이언스 코포레이션 핵산 합성을 위한 가요성 기판
CN115920796A (zh) 2015-12-01 2023-04-07 特韦斯特生物科学公司 功能化表面及其制备
EP3500672A4 (en) 2016-08-22 2020-05-20 Twist Bioscience Corporation DE NOVO SYNTHETIZED NUCLEIC ACID LIBRARIES
US10417457B2 (en) 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
GB2573069A (en) 2016-12-16 2019-10-23 Twist Bioscience Corp Variant libraries of the immunological synapse and synthesis thereof
EP4556433A3 (en) 2017-02-22 2025-08-06 Twist Bioscience Corporation Nucleic acid based data storage
WO2018170169A1 (en) 2017-03-15 2018-09-20 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
WO2018231872A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
US11407837B2 (en) 2017-09-11 2022-08-09 Twist Bioscience Corporation GPCR binding proteins and synthesis thereof
CN111565834B (zh) 2017-10-20 2022-08-26 特韦斯特生物科学公司 用于多核苷酸合成的加热的纳米孔
KR102804057B1 (ko) 2018-01-04 2025-05-07 트위스트 바이오사이언스 코포레이션 Dna 기반 디지털 정보 저장
CA3100739A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
WO2020118121A1 (en) 2018-12-06 2020-06-11 Battelle Memorial Institute Technologies for nucleotide sequence screening
WO2020139871A1 (en) 2018-12-26 2020-07-02 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
CN113766930B (zh) 2019-02-26 2025-07-22 特韦斯特生物科学公司 Glp1受体的变异核酸文库
JP2022522668A (ja) 2019-02-26 2022-04-20 ツイスト バイオサイエンス コーポレーション 抗体を最適化するための変異体核酸ライブラリ
US11332738B2 (en) 2019-06-21 2022-05-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
EP4034566A4 (en) 2019-09-23 2024-01-24 Twist Bioscience Corporation VARIANT NUCLEIC ACID BANKS FOR CRTH2
JP2022548783A (ja) 2019-09-23 2022-11-21 ツイスト バイオサイエンス コーポレーション 単一ドメイン抗体のバリアント核酸ライブラリー
BR112022011235A2 (pt) 2019-12-09 2022-12-13 Twist Bioscience Corp Bibliotecas de variantes de ácido nucleico para receptores de adenosina
US20230154569A1 (en) * 2020-01-23 2023-05-18 Massachusetts Institute Of Technology Methods of functionality screening biological sequence fragments
MX2022013499A (es) 2020-04-27 2023-01-16 Twist Bioscience Corp Bibliotecas de ácidos nucleicos variantes para coronavirus.
EP4204460A4 (en) 2020-08-26 2024-09-25 Twist Bioscience Corporation METHODS AND COMPOSITIONS RELATING TO GLP1R VARIANTS
CN117043171A (zh) 2020-08-28 2023-11-10 特韦斯特生物科学公司 用于合成的装置和方法
EP4229210A4 (en) 2020-10-19 2025-01-08 Twist Bioscience Corporation METHOD FOR THE SYNTHESIS OF OLIGONUCLEOTIDES USING BOUND NUCLEOTIDES
EP4213158A1 (en) * 2020-11-13 2023-07-19 Ahead Biocomputing, Co. Ltd Information processing device, information processing method, recording medium recording information processing program, and information processing system
KR20230147617A (ko) 2021-01-21 2023-10-23 트위스트 바이오사이언스 코포레이션 아데노신 수용체에 관한 방법 및 조성물
EP4314075A4 (en) 2021-03-24 2025-04-09 Twist Bioscience Corporation VARIANT NUCLEIC ACID BANKS FOR CD3
WO2022235584A1 (en) 2021-05-03 2022-11-10 Twist Bioscience Corporation Variant nucleic acid libraries for glycans
US12201857B2 (en) 2021-06-22 2025-01-21 Twist Bioscience Corporation Methods and compositions relating to covid antibody epitopes
WO2023023285A2 (en) 2021-08-19 2023-02-23 Twist Bioscience Corporation Methods and compositions relating to covalently closed nucleic acids
WO2023069985A1 (en) * 2021-10-19 2023-04-27 Battelle Memorial Institute Technologies for genetic engineering detection
US12134656B2 (en) 2021-11-18 2024-11-05 Twist Bioscience Corporation Dickkopf-1 variant antibodies and methods of use
EP4460516A2 (en) 2022-01-03 2024-11-13 Twist Bioscience Corporation Bispecific sars-cov-2 antibodies and methods of use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170802A1 (en) 1999-02-19 2009-07-02 Febit Holding Gmbh Method for producing polymers
US20100292102A1 (en) 2009-05-14 2010-11-18 Ali Nouri System and Method For Preventing Synthesis of Dangerous Biological Sequences
US20110172127A1 (en) 2008-08-27 2011-07-14 Westemd Asset Clearinghouse Company, LLC Methods and Devices for High Fidelity Polynucleotide Synthesis
US20150120265A1 (en) * 2011-09-01 2015-04-30 Genome Compiler Corporation System for polynucleotide construct design, visualization and transactions to manufacture the same
US20160096160A1 (en) 2013-08-05 2016-04-07 Twist Bioscience Corporation De novo synthesized gene libraries

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5701256A (en) * 1995-05-31 1997-12-23 Cold Spring Harbor Laboratory Method and apparatus for biological sequence comparison
CA2577741A1 (en) * 2004-08-18 2006-03-02 Abbott Molecular, Inc. Determining data quality and/or segmental aneusomy using a computer system
EP2718862B1 (en) * 2011-06-06 2018-10-31 Koninklijke Philips N.V. Method for assembly of nucleic acid sequence data
US10347361B2 (en) * 2012-10-24 2019-07-09 Nantomics, Llc Genome explorer system to process and present nucleotide variations in genome sequence data

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170802A1 (en) 1999-02-19 2009-07-02 Febit Holding Gmbh Method for producing polymers
US20110172127A1 (en) 2008-08-27 2011-07-14 Westemd Asset Clearinghouse Company, LLC Methods and Devices for High Fidelity Polynucleotide Synthesis
US20100292102A1 (en) 2009-05-14 2010-11-18 Ali Nouri System and Method For Preventing Synthesis of Dangerous Biological Sequences
US20150120265A1 (en) * 2011-09-01 2015-04-30 Genome Compiler Corporation System for polynucleotide construct design, visualization and transactions to manufacture the same
US20160096160A1 (en) 2013-08-05 2016-04-07 Twist Bioscience Corporation De novo synthesized gene libraries

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JP2019523940A (ja) 2019-08-29
WO2017214574A1 (en) 2017-12-14
US20170357752A1 (en) 2017-12-14
CN109564769A (zh) 2019-04-02
JP2022181213A (ja) 2022-12-07
EP3469499A4 (en) 2020-10-21
KR20190017932A (ko) 2019-02-20
CA3027127A1 (en) 2017-12-14
EP3469499A1 (en) 2019-04-17
SG11201811025VA (en) 2019-01-30

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