KR102450970B1 - Glaucoma drainage device and method for manufacturing thereof - Google Patents

Abstract

The present invention relates to a waterproof outflow device and a manufacturing method thereof, wherein the waterproof outflow device according to an embodiment of the present invention is disposed on the sclera under the conjunctiva, and temporarily stores aqueous humor leaked from the eyeball therein, Formed in a plate shape, the body 10 is curved inwardly so that the lower surface in contact with the sclera corresponds to the outer surface of the sclera, and a waterproof outlet 21 is provided at one end, and a waterproof inlet 23 at the other end ) is formed in the form of a hollow tube with both ends open, the waterproof outlet 21 is connected to the main body 10, and the waterproof inlet 23 is inserted into the anterior chamber to provide the waterproofing housed in the front inside. and an outlet tube 20 for outflow.

Description

Waterproof outflow device and manufacturing method thereof

The present invention relates to a waterproof outflow device and a method for manufacturing the same, and more particularly, to a glaucoma implant technology for controlling intraocular pressure by outflowing aqueous humor.

As a treatment method for glaucoma in which the optic nerve damage progresses and the visual field defect appears, there are mainly three methods used: drug treatment, laser treatment, and surgical treatment. Drug treatment is a method of lowering intraocular pressure or increasing ocular blood flow by instilling a drug directly into the eye. Trabeculectomy and insertion of an aqueous outflow device are commonly performed on the principle of creating a passage for intraocular aqueous humor to pass through the outer ocular wall to an appropriate degree. Referring to Figure 1, the conventional waterproof outflow device used for surgical treatment is mainly connected to a silicone tube (2) to a plate (1) made of silicone or polypropylene (polypropylene), to reduce the possibility of low intraocular pressure after surgery, Between the tube (2) and the plate (1), a waterproof backflow shutoff valve is built in. The procedure of the aqueous drainage device insertion procedure is slightly different for each ophthalmologist, but in general, the aqueous drainage device is inserted under the conjunctiva by incision of the conjunctiva, and after fixing the plate (1) and sclera with sutures, the tube (2) is A hole is made in the passing sclera region and the tube 2 is inserted into the anterior chamber, and the conjunctiva is sutured. When the waterproof outflow device is inserted in this way, the aqueous humor in the anterior chamber sequentially passes through the tube 2 and the plate 1 and spreads to the surrounding space under the conjunctiva, so that the intraocular pressure is controlled.

However, since the conventional waterproof outflow device is manufactured with a uniform design without considering individual patients, various problems occur when applied to eyes of different shapes for each patient. The tube 2 placed in the anterior chamber is not oriented correctly, so the tube 2 may touch or puncture the cornea, causing corneal edema. The patient may complain of discomfort because it does not fit well into the eyeball of the patient. In addition, since the tube 2 is formed in a straight shape, the tube 2 also does not fit well in the spherical eye, which may cause complications such as tube exposure.

Accordingly, there is an urgent need for a method to solve the problems of the conventional waterproof outflow device.

US 10-0323807 B1

SUMMARY OF THE INVENTION The present invention is to solve the problems of the prior art described above, and an aspect of the present invention is to provide a waterproof outflow device in which a tube and/or a body for draining water are curved to correspond to the shape of an individual eyeball.

In addition, an object of the present invention is to provide a method for manufacturing a waterproof outflow device that matches an individual's OCT and MRI images and manufactures a personalized waterproofing outflow device based on the measured eye curvature.

The waterproof outflow device according to an embodiment of the present invention is disposed on the sclera under the conjunctiva, temporarily stores aqueous humor leaked from the eyeball therein, and is formed in a plate shape, which is in contact with the sclera. The body is curved inwardly so that the lower surface corresponds to the outer surface of the sclera; And a waterproof outlet is provided at one end, and is formed in the form of a hollow tube having both ends open so that a waterproof inlet is provided at the other end, the waterproof outlet is connected to the main body, and the waterproof inlet is inserted into the anterior chamber , an outlet tube for discharging the water-repellent accommodated in the front interior; includes.

In addition, in the waterproof outflow device according to the embodiment of the present invention, the lower surface of the main body may be curved based on the curvature of the eyeball for each individual glaucoma patient.

In addition, in the waterproof outflow device according to the embodiment of the present invention, the main body may be arranged in a region 5 to 30 mm away from the corneal limbus.

In addition, in the waterproof outflow device according to an embodiment of the present invention, the outlet tube may be curved to correspond to the outer surface of the sclera along the longitudinal direction.

In addition, in the waterproof outflow device according to an embodiment of the present invention, the outflow tube may be curved based on the curvature of the eyeball for each individual glaucoma patient.

In addition, in the waterproof outflow device according to the embodiment of the present invention, the waterproof inlet may be inserted into the anterior chamber through a region of the sclera that is 2 to 4 mm away from the corneal limbus.

In addition, in the waterproof outflow device according to an embodiment of the present invention, the other end of the outlet tube may be formed obliquely so that the length of the lower part facing the sclera is longer than the length of the upper part facing the conjunctiva. have.

In addition, in the waterproof outflow device according to the embodiment of the present invention, the outflow tube, along the longitudinal direction, may be provided with at least one or more perforated lines.

In addition, in the waterproof outflow device according to an embodiment of the present invention, the lower surface of the outlet tube facing the sclera may be curved inward to correspond to the outer surface of the sclera along the width direction.

In addition, in the waterproof outflow device according to an embodiment of the present invention, the other end of the outflow tube is inclined at a predetermined angle with respect to the center of the outflow tube so as to be disposed between the cornea and the iris when inserted in the front. can

In addition, in the waterproof outflow device according to an embodiment of the present invention, at least one auxiliary inlet penetrating through the outer surface of the outflow tube so that the waterproof is introduced into the inside is formed on the outer circumferential surface of the region inserted into the front inside. can

On the other hand, the method of manufacturing a waterproofing outflow device according to an embodiment of the present invention comprises the steps of: (a) generating a matched image by matching the OCT image and the MRI image obtained by photographing the individual eyes of the glaucoma patient; (b) obtaining a super-temporal image of the eyeball from the generated matched image; (c) measuring the curvature of the eyeball from the acquired disparity image; and (d) manufacturing the lower surface of the body to correspond to the measured curvature of the eyeball.

In addition, in the method for manufacturing a waterproofing outflow device according to an embodiment of the present invention, in step (a), the matched image may be generated by matching the OCT image and the MRI image with respect to the corneal limbus. have.

In addition, in the method for manufacturing a waterproofing outflow device according to an embodiment of the present invention, in the step (c), the curvature of the eyeball is a region from the corneal limbus to a distance of 30 mm from the upper-parietal image. It may be a curvature measured in .

In addition, in the method for manufacturing a waterproofing outflow device according to an embodiment of the present invention, both ends are in the form of a hollow tube, and when one end is connected to the main body, the other end of the sclera is 2 to 4 mm away from the corneal limbus. Cutting the length so as to be inserted into the front (anterior chamber) through the region, manufacturing the outlet tube; may further include.

The features and advantages of the present invention will become more apparent from the following detailed description taken in conjunction with the accompanying drawings.

Prior to this, the terms or words used in the present specification and claims should not be construed in a conventional and dictionary meaning, and the inventor may properly define the concept of the term to describe his invention in the best way. Based on the principle that there is, it should be interpreted as meaning and concept consistent with the technical idea of the present invention.

According to the present invention, since the tube and/or the body that drains the aqueous humor is curved to correspond to the shape of the individual eyeball, the tube and/or the body fits the eye well, thereby reducing complications such as corneal contact or tube exposure, and the patient It can reduce the feeling of discomfort.

In addition, personalized waterproofing implemented with a structure optimized for the patient's eye by matching the OCT and MRI images taken for each patient, measuring the eye curvature from it, and designing the tube and/or body based on the eye curvature. It is possible to build an outflow device.

1 is a perspective view of a conventional waterproof outflow device.
2 is a perspective view of a waterproof outflow device according to a first embodiment of the present invention.
FIG. 3 is a cross-sectional view taken along line AA′ of FIG. 2 .
Figure 4 is a cross-sectional view taken along the line BB' of Figure 3 of the outlet tube of the waterproof outflow device according to the second embodiment of the present invention.
5 is a side view showing an outlet tube of a waterproof outflow device according to a third embodiment of the present invention.
6 is a perspective view showing an outlet tube of a waterproof outflow device according to a fourth embodiment of the present invention.
7 is a side view showing an outlet tube of a waterproof outflow device according to a fifth embodiment of the present invention.
8 is a perspective view showing an outlet tube of a waterproof outflow device according to a fifth embodiment of the present invention.
9 is a flowchart of a method for manufacturing a waterproof outflow device according to an embodiment of the present invention.
10 is a diagram illustrating a step of generating a matched image in a method for manufacturing a waterproof outflow device according to an embodiment of the present invention.

The objects, specific advantages and novel features of the present invention will become more apparent from the following detailed description taken in conjunction with the accompanying drawings and preferred embodiments. In the present specification, in adding reference numbers to the components of each drawing, it should be noted that only the same components are given the same number as possible even though they are indicated on different drawings. In addition, terms such as “first” and “second” are used to distinguish one component from another, and the component is not limited by the terms. Hereinafter, in describing the present invention, detailed descriptions of related known technologies that may unnecessarily obscure the subject matter of the present invention will be omitted.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 2 is a perspective view of a waterproof outflow device according to a first embodiment of the present invention, and FIG. 3 is a cross-sectional view taken along line A-A' of FIG. 2 .

2 to 3, the waterproof outflow device according to the first embodiment of the present invention is disposed on the sclera under the conjunctiva, and temporarily stores aqueous humor leaked from the eyeball therein, and a plate Formed in a (plate) shape, the body 10 is curved inwardly so that the lower surface in contact with the sclera corresponds to the outer surface of the sclera, and a waterproof outlet 21 is provided at one end, and a waterproof inlet 23 at the other end. is formed in the form of a hollow tube with both ends open so as to be provided, the waterproof outlet 21 is connected to the main body 10, and the waterproof inlet 23 is inserted into the anterior chamber to drain the waterproofing received in the front interior and an outlet tube (20).

The present invention relates to an aqueous humor outflow device for lowering intraocular pressure by draining the aqueous humor of the eyeball for the treatment of glaucoma. The waterproof outflow device generally used for surgical treatment of glaucoma has a tube connected to one side of a plate that is sutured to the sclera under the conjunctiva, and the tube is inserted into the anterior chamber to drain the aqueous humor. The plate is flat and the tube is designed in a straight line without considering the different eye shapes. Therefore, the plate and tube do not fit well with the spherical eyeball, causing discomfort to the patient and complications such as corneal contact or tube exposure. Accordingly, the present invention has been devised to solve the problems of the conventional waterproof outflow device.

Specifically, the waterproof outflow device according to an embodiment of the present invention includes a body 10 and an outflow tube 20 .

The body 10 is a plate-shaped member, and has an accommodation space therein so that aqueous humor leaked from the eyeball is temporarily stored. This body 10 is disposed on the sclera under the conjunctiva, and can discharge temporarily stored aqueous humor into the surrounding space under the conjunctiva. Here, the lower surface of the body 10 is disposed in contact with the outer surface of the sclera, the lower surface is formed in a curved (curved) form inward to correspond to the outer surface of the sclera. That is, the lower surface of the main body 10 is formed in a concave recessed form so as to correspond to the shape of the region in which the main body 10 is disposed among the convex outer surfaces of the spherical sclera. The main body 10 may be disposed within a region 5 to 30 mm away from the corneal limbus, which is the boundary between the cornea and the sclera. Accordingly, the lower surface of the main body 10 may be formed to correspond to the shape of the ocular curved surface within the region connecting the point 5 mm away from the corneal limbus and the point 30 mm away. Here, the lower surface of the main body 10 may be manufactured based on the curvature of the eyeball measured for each individual glaucoma patient. The curvature of the individual eyeball may be measured using an image photographed using an ophthalmic imaging device. For example, an OCT image or an MRI image, or an OCT image and an MRI image may be measured from a matched image. When the main body 10 is manufactured based on the curvature of the individual eyeballs, a personalized waterproof outflow device optimized for the patient's individual eyes can be implemented.

In this way, when the lower surface of the main body 10 is formed in a shape corresponding to the outer surface of the sclera, the spaced space between the main body 10 and the sclera is minimized or does not exist, so that the main body 10 is fixed in close contact with the sclera This reduces the discomfort felt by the patient.

On the other hand, the water temporarily stored in the body 10 and discharged around the conjunctiva flows into the body 10 by inserting the outflow tube 20 into the anterior chamber, which is the space between the cornea and the iris of the eyeball.

The outlet tube 20 is a fine conduit in the form of a hollow tube having both ends open. The opening opened at one end of the outlet tube 20 becomes the waterproof outlet 21 , and the opening at the other end of the outlet tube 20 becomes the waterproof inlet 23 . One end of the outlet tube 20 having the waterproof outlet 21 formed thereon is connected to the body 10, but the other end of the outlet tube 20 having the waterproof inlet 23 formed thereon is a free end that does not receive any support or restraint. ) becomes The other end of the outlet tube 20 passes through the sclera and is inserted into the anterior chamber. Here, the waterproof inlet 23 may be inserted into the anterior chamber through the sclera 2 to 4 mm away from the corneal limbus. As the waterproof inlet 23 is inserted into the front in this way, the water received in the front is introduced into the hollow of the outlet tube 20 through the waterproof inlet 23, and through the waterproof outlet 21 of the body 10 After it has flowed inside, it can spread to the space below the conjunctiva.

On the other hand, one end of the outlet tube 20 is connected to the body 10, and the other end of the outlet tube 20 is inserted in the front, but the center of the outlet tube 20 connecting the one end and the other end is between the conjunctiva and the sclera. will be located in Accordingly, in order to prevent exposure of the conjunctiva of the outlet tube 20, the outlet tube 20 may be curved in a shape corresponding to the outer surface of the sclera along the longitudinal direction. That is, when the direction looking at the conjunctiva with the outflow tube 20 as the center is upward and the direction looking at the sclera is downward, the outflow tube 20 viewed from the side is curved in a bow shape. can Here, the degree of curvature of the outlet tube 20 may be curved to correspond to the shape of the region in which the center of the outlet tube 20 is disposed among the convex outer surfaces of the spherical sclera. The outflow tube 20 curved in the longitudinal direction in this way may be manufactured based on the curvature of the eyeball measured for each individual glaucoma patient. As described above, the curvature of the individual eyeball can be measured from an OCT image or an MRI image, or an image obtained by matching the OCT image and the MRI image, and the outflow tube 20 is made to be curved based on the curvature of the individual eyeball. A waterproof outflow device can be implemented.

Overall, according to the present invention, since the lower surface of the main body 10 is curved inwardly in a form corresponding to the outer surface region of the sclera in which the main body 10 is disposed, the main body 10 is formed to fit the eyeball well and the patient feels It can reduce discomfort. In addition, since the outlet tube 20 can also be curved to correspond to the area of the outer surface of the sclera in which it is located, complications such as corneal contact or tube exposure can be reduced.

Figure 4 is a cross-sectional view taken along the line B-B' of Figure 3 of the outlet tube of the waterproof outflow device according to the second embodiment of the present invention.

Referring to FIG. 4 , the lower surface of the outlet tube 20 of the waterproof outflow device according to the second embodiment of the present invention may be curved inwardly to correspond to the outer surface of the sclera along the width direction. Here, the lower surface of the outlet tube 20 means a surface facing the sclera among the outer surfaces of the outlet tube 20 , and the width direction of the outlet tube 20 is a longitudinal direction connecting one end and the other end of the outlet tube 20 . lateral direction perpendicular to Thus, even along the width direction, the lower surface of the outlet tube 20 is concave to correspond to the convex outer surface of the sclera, so that the area of the outlet tube 20 in contact with the sclera is widened and can be stably fixed to the sclera . However, the lower surface of the outlet tube 20 does not necessarily have to be formed in a concave concave shape, but may be formed flat. On the other hand, the hollow cross-section of the outlet tube 20 may be circular, but is not necessarily limited to a circular cross-section.

5 is a side view showing an outlet tube of a waterproof outflow device according to a third embodiment of the present invention.

5, the other end of the outflow tube 20 of the waterproof outflow device according to the third embodiment of the present invention is predetermined with respect to the center of the outflow tube 20 so as to be positioned between the cornea and the iris when inserted in the front. It may be formed to be inclined at an angle of . When the other end of the outlet tube 20 inserted in the front touches or punctures the cornea, complications such as corneal edema may occur, so that the angle of the other end of the outlet tube 20 may be adjusted so as not to touch the cornea. For example, using the OCT image of the patient, the angle of the other end of the outlet tube 20 may be adjusted to be parallel to the iris as much as possible without touching the cornea.

6 is a perspective view showing an outlet tube of a waterproof outflow device according to a fourth embodiment of the present invention.

6, the other end of the outflow tube 20 of the waterproof outflow device according to the fourth embodiment of the present invention is inclined so that the length of the lower part facing the sclera is longer than the length of the upper part facing the conjunctiva. can be formed. When the other end of the outlet tube 20 is formed with a sharp lower portion in this way, it is easy to insert into the anterior chamber through the sclera, and even if the other end of the outlet tube 20 is straightened toward the cornea, the outlet tube 20 is relatively short. Since the upper part of the other end faces the cornea, contact with the cornea can be prevented as much as possible.

7 is a side view showing an outlet tube of a waterproof outflow device according to a fifth embodiment of the present invention.

Referring to FIG. 7 , the outlet tube 20 of the waterproof outflow device according to the fifth embodiment of the present invention may include one or more perforated lines 25 . The perforated line 25 may be formed as a groove in the form of at least one or more dots or grooves arranged in the circumferential direction on the outer surface of the outlet tube 20 . At this time, the groove of the perforated line 25 may be formed in the form of a blind hole rather than a through-hole form so that the waterproofing flowing along the inner hollow of the outlet tube 20 does not leak through the perforated line 25 . . Since the perforated line 25 is formed along the circumferential direction on the outer surface of the outlet tube 20 , when the outlet tube 20 is cut along the perforated line 25 , the length of the outlet tube 20 can be adjusted. Since the shape of the eye for each patient, the position where the main body 10 is disposed, the position where the outlet tube 20 is inserted, etc. are different from each other, it is necessary to adjust the length of the outlet tube 20, and the perforated line 25 is provided. and its length can be easily adjusted. Here, the perforated line 25 may be formed to be cut perpendicularly to the longitudinal direction of the outlet tube 20 . Alternatively, as shown in FIG. 6 , the perforated line 25 may be formed to be diagonally cut with respect to the longitudinal direction of the outlet tube 20 so that the other end of the outlet tube 20 is formed obliquely. However, since the perforated line 25 is not necessarily formed to be cut perpendicularly or obliquely to the longitudinal direction of the outlet tube 20, the scope of rights should not be limited thereby.

8 is a perspective view showing an outlet tube of a waterproof outflow device according to a fifth embodiment of the present invention.

As shown in FIG. 8 , at least one auxiliary inlet 27 may be formed in the outlet tube 20 of the waterproof outflow device according to the fifth embodiment of the present invention. Here, the auxiliary inlet 27 is an opening for introducing water into the inside of the outlet tube 20 in addition to the waterproof inlet 23 . The auxiliary inlet 27 may be implemented in the form of a through-hole penetrating the outer circumferential surface of the region to be inserted into the front of the outer surface of the outlet tube 20 . One or two or more auxiliary inlets 27 may be formed, and a plurality of auxiliary inlets 27 may be formed on the outer surface of the outlet tube 20 along the circumferential direction.

Hereinafter, a method for manufacturing a waterproof outflow device according to the present invention will be described. As described above for the waterproof outflow device according to the present invention, the overlapping contents will be omitted or simply described.

9 is a flowchart of a method for manufacturing a waterproofing outflow device according to an embodiment of the present invention, and FIG.

As shown in FIGS. 9 to 10 , the method for manufacturing a waterproofing outflow device according to an embodiment of the present invention includes the steps of generating a registered image by matching the OCT image and the MRI image obtained by photographing the individual eyeballs of the glaucoma patient (S100). ), acquiring a super-temporal image of the eyeball from the generated matched image (S200), measuring the curvature of the eyeball from the acquired super-temporal image (S300), and the measured curvature of the eyeball To correspond, including the step (S400) of manufacturing the lower surface of the body.

The waterproof outflow device manufacturing method according to an embodiment of the present invention is a method of manufacturing a personalized waterproofing outflow device based on an eye curvature measured for an individual patient, and includes a matching image generation step (S100), a disparity side image acquisition step ( S200), an eye curvature measurement step (S300), and a body manufacturing step (S400).

In the registration image generating step (S100), an OCT image and an MRI image obtained by photographing an individual eye of a glaucoma patient using OCT and MRI imaging equipment are prepared, and a registered image is generated by registering the OCT image and the MRI image. In this case, a registered image may be generated by combining the OCT image and the MRI image based on the corneal limbus.

In the disparity-side image acquisition step ( S200 ), a super-temporal 1/4 image of the individual eye may be acquired from the matched image.

The eye curvature measuring step S300 is a process of measuring the curvature of an individual eyeball. Here, in consideration of the location and the size (length) of the main body of the waterproof outflow device, the eye curvature may be measured from the superior side image. In this case, the curvature of the eye may be a curvature measured in a region up to a distance of 30 mm away from the limbus in the superior-side image. For example, if the front end of the main body is placed at a point 8 mm away from the limbus, and the length of the main body is 16 mm, the curvature in the region connecting the limbus of the quadrant of the superior image and the point 25 mm away from there can be measured.

In the body manufacturing step (S400), based on the measured curvature of the eyeball, the lower surface of the body is manufactured to correspond to the curvature. Here, the lower surface of the body is manufactured to be concavely curved according to the measured curvature.

On the other hand, the outlet tube is in the form of a hollow tube with both ends open, and when one end is connected to the main body, the other end penetrates the area of the sclera 2 to 4 mm away from the corneal limbus and is inserted into the anterior chamber. It can be manufactured by cutting. The outlet tube may be formed in a curved shape along the longitudinal direction, and the degree of the curvature may depend on the curvature measured in the eyeball curvature measuring step ( S300 ). In addition, it is curved inward to correspond to the outer surface of the sclera along the width direction, or may form a lower surface of the outlet tube in equilibrium. In addition, by using the patient's OCT image, the angle of the outflow tube can be adjusted as much as possible parallel to the iris without touching the cornea when inserted into the anterior chamber. In addition, the other end of the outlet tube may be formed obliquely so that the length of the lower part facing the sclera is longer than the length of the upper part facing the conjunctiva. In addition, at least one perforation line may be formed along the longitudinal direction of the outlet tube in the form of at least one dot or groove in the circumferential direction on the outer surface of the outlet tube. In addition, the auxiliary inlet may be formed in the form of a through hole penetrating the outer circumferential surface of the region to be inserted into the front of the outer surface of the outlet tube.

Such a body and outlet tube can be manufactured using a 3D printing process based on the measured curvature of the eyeball. However, the production of the body and the outlet tube is not necessarily limited to the 3D printing process.

Overall, according to the present invention, by matching OCT and MRI images taken for each patient, measuring the ocular curvature therefrom, and designing a tube and/or body based on the ocular curvature, a structure optimized for the patient's eye It is possible to manufacture a personalized waterproof outflow device implemented with

Although the present invention has been described in detail through specific examples, it is intended to describe the present invention in detail, and the present invention is not limited thereto, and by those of ordinary skill in the art within the technical spirit of the present invention. It is clear that the modification or improvement is possible.

All simple modifications and variations of the present invention belong to the scope of the present invention, and the specific protection scope of the present invention will be made clear by the appended claims.

1: Plate 2: Tube
10: body 20: outlet tube
21: waterproof outlet 23: waterproof inlet
25: perforated line 27: auxiliary inlet

Claims (15)

delete delete delete delete delete delete delete delete delete delete delete It is disposed on the sclera under the conjunctiva, temporarily stores aqueous humor leaked from the eyeball therein, and is formed in a plate shape so that the lower surface in contact with the sclera corresponds to the outer surface of the sclera. A body curved into a , and a waterproof outlet is provided at one end, and is formed in the form of a hollow tube having both ends open so that a waterproof inlet is provided at the other end, the waterproof outlet is connected to the main body, and the waterproof inlet is provided in the front (anterior) In the method for manufacturing a waterproof outflow device, which is inserted into the chamber) and includes an outflow tube for outflowing the waterproofing accommodated in the front inside,
(a) generating a registered image by matching the OCT image and the MRI image obtained by taking the respective eyeballs of the individual glaucoma patient;
(b) obtaining a super-temporal image of the eyeball from the generated matched image;
(c) measuring the curvature of the eyeball from the acquired disparity image; and
(d) manufacturing the lower surface of the main body so as to correspond to the measured curvature of the eyeball;
13. The method of claim 12,
In the step (a), the matched image is generated by matching the OCT image and the MRI image based on the corneal limbus.
13. The method of claim 12,
In the step (c), the curvature of the eyeball is a curvature measured in a region up to a distance of 30 mm from the corneal limbus in the superior-side image.
13. The method of claim 12,
It is in the form of a hollow tube with both ends open, and when one end is connected to the main body, the other end penetrates the area of the sclera 2 to 4 mm away from the corneal limbus and cuts the length so that it is inserted into the anterior chamber, The method of manufacturing a waterproof outflow device further comprising; manufacturing the outlet tube.

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