KR102435658B1 - 니코틴 백신 개발을 위한 광학순도 합텐 - Google Patents

니코틴 백신 개발을 위한 광학순도 합텐 Download PDF

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Publication number
KR102435658B1
KR102435658B1 KR1020167035358A KR20167035358A KR102435658B1 KR 102435658 B1 KR102435658 B1 KR 102435658B1 KR 1020167035358 A KR1020167035358 A KR 1020167035358A KR 20167035358 A KR20167035358 A KR 20167035358A KR 102435658 B1 KR102435658 B1 KR 102435658B1
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South Korea
Prior art keywords
nicotine
hapten
antibodies
vaccine
formula
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Expired - Fee Related
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KR1020167035358A
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English (en)
Korean (ko)
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KR20170007810A (ko
Inventor
김 디. 잔다
조나단 더블유. 로크너
Original Assignee
더 스크립스 리서치 인스티튜트
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Publication of KR20170007810A publication Critical patent/KR20170007810A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y10S514/813—

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020167035358A 2014-05-19 2015-05-19 니코틴 백신 개발을 위한 광학순도 합텐 Expired - Fee Related KR102435658B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462000312P 2014-05-19 2014-05-19
US62/000,312 2014-05-19
PCT/US2015/031583 WO2015179403A1 (en) 2014-05-19 2015-05-19 Enantiopure haptens for nicotine vaccine development

Publications (2)

Publication Number Publication Date
KR20170007810A KR20170007810A (ko) 2017-01-20
KR102435658B1 true KR102435658B1 (ko) 2022-08-23

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KR1020167035358A Expired - Fee Related KR102435658B1 (ko) 2014-05-19 2015-05-19 니코틴 백신 개발을 위한 광학순도 합텐

Country Status (8)

Country Link
US (3) US20170107275A1 (enExample)
EP (1) EP3145920B1 (enExample)
JP (1) JP6564396B2 (enExample)
KR (1) KR102435658B1 (enExample)
CN (2) CN106458971A (enExample)
AU (1) AU2015264325B2 (enExample)
CA (1) CA2949667C (enExample)
WO (1) WO2015179403A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015264325B2 (en) 2014-05-19 2019-02-14 The Scripps Research Institute Enantiopure haptens for nicotine vaccine development
CN118161604B (zh) * 2024-03-25 2025-01-14 海南大学 一种尼古丁蛋白缀合物、其制备方法及在疫苗中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110217320A1 (en) 1998-12-01 2011-09-08 Nabi Biopharmaceuticals Hapten-carrier conjugates for treating and preventing nicotine addiction
US20130131015A1 (en) 2006-03-29 2013-05-23 North Carolina State University Synthesis and regioselective substitution of 6-halo- and 6-alkoxy nicotine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
SE9801923D0 (sv) * 1998-05-29 1998-05-29 Independent Pharmaceutical Ab Nicotine vaccine
WO2007064478A2 (en) * 2005-11-28 2007-06-07 Nabi Biopharmaceuticals Method for making nicotine hapten
WO2007100755A1 (en) * 2006-02-27 2007-09-07 Nabi Biopharmaceuticals Method for decreasing the toxic effects of nicotine on fetuses in pregnant women
TWI455722B (zh) * 2010-06-04 2014-10-11 Pfizer Vaccines Llc 用於預防或治療菸鹼成癮之共軛體
AU2015264325B2 (en) 2014-05-19 2019-02-14 The Scripps Research Institute Enantiopure haptens for nicotine vaccine development
US9884114B2 (en) * 2015-06-23 2018-02-06 Arizona Board Of Regents On Behalf Of Arizona State University Methods of rational nicotine hapten design and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110217320A1 (en) 1998-12-01 2011-09-08 Nabi Biopharmaceuticals Hapten-carrier conjugates for treating and preventing nicotine addiction
US20130131015A1 (en) 2006-03-29 2013-05-23 North Carolina State University Synthesis and regioselective substitution of 6-halo- and 6-alkoxy nicotine derivatives

Also Published As

Publication number Publication date
CN106458971A (zh) 2017-02-22
AU2015264325A1 (en) 2016-12-01
US20180086820A1 (en) 2018-03-29
EP3145920A1 (en) 2017-03-29
CN110452217A (zh) 2019-11-15
EP3145920B1 (en) 2019-09-18
JP2017515867A (ja) 2017-06-15
US20190119363A1 (en) 2019-04-25
CA2949667A1 (en) 2015-11-26
EP3145920A4 (en) 2017-12-27
JP6564396B2 (ja) 2019-08-21
AU2015264325B2 (en) 2019-02-14
US10487141B2 (en) 2019-11-26
CN110452217B (zh) 2022-12-27
US20170107275A1 (en) 2017-04-20
KR20170007810A (ko) 2017-01-20
CA2949667C (en) 2022-05-03
WO2015179403A1 (en) 2015-11-26

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