CN106458971A - 用于尼古丁疫苗开发的光学纯半抗原 - Google Patents

用于尼古丁疫苗开发的光学纯半抗原 Download PDF

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Publication number
CN106458971A
CN106458971A CN201580026158.9A CN201580026158A CN106458971A CN 106458971 A CN106458971 A CN 106458971A CN 201580026158 A CN201580026158 A CN 201580026158A CN 106458971 A CN106458971 A CN 106458971A
Authority
CN
China
Prior art keywords
nicotine
hapten
antibodies
carrier
vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580026158.9A
Other languages
English (en)
Chinese (zh)
Inventor
金姆·D·扬达
乔纳森·W·洛克尼尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Priority to CN201910630434.2A priority Critical patent/CN110452217B/zh
Publication of CN106458971A publication Critical patent/CN106458971A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Addiction (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201580026158.9A 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原 Pending CN106458971A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910630434.2A CN110452217B (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462000312P 2014-05-19 2014-05-19
US62/000,312 2014-05-19
PCT/US2015/031583 WO2015179403A1 (en) 2014-05-19 2015-05-19 Enantiopure haptens for nicotine vaccine development

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201910630434.2A Division CN110452217B (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原

Publications (1)

Publication Number Publication Date
CN106458971A true CN106458971A (zh) 2017-02-22

Family

ID=54554631

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580026158.9A Pending CN106458971A (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原
CN201910630434.2A Expired - Fee Related CN110452217B (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201910630434.2A Expired - Fee Related CN110452217B (zh) 2014-05-19 2015-05-19 用于尼古丁疫苗开发的光学纯半抗原

Country Status (8)

Country Link
US (3) US20170107275A1 (enExample)
EP (1) EP3145920B1 (enExample)
JP (1) JP6564396B2 (enExample)
KR (1) KR102435658B1 (enExample)
CN (2) CN106458971A (enExample)
AU (1) AU2015264325B2 (enExample)
CA (1) CA2949667C (enExample)
WO (1) WO2015179403A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118161604A (zh) * 2024-03-25 2024-06-11 海南大学 一种尼古丁蛋白缀合物、其制备方法及在疫苗中的应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2949667C (en) 2014-05-19 2022-05-03 The Scripps Research Institute Enantiopure haptens for nicotine vaccine development

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032239A1 (en) * 1998-12-01 2000-06-08 Nabi Hapten-carrier conjugates for treating and preventing nicotine addiction
US7446205B2 (en) * 2005-11-28 2008-11-04 Nabi Biopharmaceuticals Method for making nicotine hapten

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
SE9801923D0 (sv) * 1998-05-29 1998-05-29 Independent Pharmaceutical Ab Nicotine vaccine
US7547712B2 (en) * 2006-02-27 2009-06-16 Nabi Biopharmaceuticals Methods for decreasing the toxic effects of nicotine on fetuses in pregnant women
JP2009531442A (ja) * 2006-03-29 2009-09-03 ノース・キャロライナ・ステイト・ユニヴァーシティ ６−ハロおよび６−アルコキシニコチン誘導体の合成および位置選択的置換
TWI578997B (zh) * 2010-06-04 2017-04-21 輝瑞疫苗有限責任公司 用於預防或治療菸鹼成癮之共軛體
CA2949667C (en) 2014-05-19 2022-05-03 The Scripps Research Institute Enantiopure haptens for nicotine vaccine development
US9884114B2 (en) * 2015-06-23 2018-02-06 Arizona Board Of Regents On Behalf Of Arizona State University Methods of rational nicotine hapten design and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032239A1 (en) * 1998-12-01 2000-06-08 Nabi Hapten-carrier conjugates for treating and preventing nicotine addiction
US7446205B2 (en) * 2005-11-28 2008-11-04 Nabi Biopharmaceuticals Method for making nicotine hapten

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAVID C. PRYDE ET AL.: "Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice", 《PLOS ONE》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118161604A (zh) * 2024-03-25 2024-06-11 海南大学 一种尼古丁蛋白缀合物、其制备方法及在疫苗中的应用

Also Published As

Publication number Publication date
EP3145920B1 (en) 2019-09-18
KR102435658B1 (ko) 2022-08-23
CN110452217B (zh) 2022-12-27
KR20170007810A (ko) 2017-01-20
CA2949667A1 (en) 2015-11-26
CA2949667C (en) 2022-05-03
US20180086820A1 (en) 2018-03-29
AU2015264325A1 (en) 2016-12-01
JP2017515867A (ja) 2017-06-15
CN110452217A (zh) 2019-11-15
US10487141B2 (en) 2019-11-26
US20170107275A1 (en) 2017-04-20
US20190119363A1 (en) 2019-04-25
EP3145920A1 (en) 2017-03-29
EP3145920A4 (en) 2017-12-27
AU2015264325B2 (en) 2019-02-14
JP6564396B2 (ja) 2019-08-21
WO2015179403A1 (en) 2015-11-26

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Legal Events

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C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170222