KR102435022B1 - Multi manifold type unit module of sample sampling apparatus and sample sampling apparatus - Google Patents

Abstract

The present invention relates to a multi-manifold type unit module of a sample sampling device and a sample sampling device that allow the number of sampling lines to be freely added, and includes a first path therein, and a branching point from the first path. a unit module body in which a second path and a third path are formed; a diaphragm valve member formed on a first surface of the unit module body and connected to the first path; It is formed on the second surface of the unit module body, is connected to the second path, is connected to the main tube connected to the sample bag, or is multi-connected to the diaphragm valve member of another neighboring unit module to form a multi-modular manifold a first temporary cap member for temporarily sealing the connection hole; a luer lock member formed on a third surface of the unit module body, connected to the third path, and connected to a sampling tube of the sampling bag to supply a desired amount of culture solution to the sampling bag; a valve body installed at the branch point of the unit module body and axially rotating along a rotation axis to block the first path or selectively connect the first path to the second path or the third path; and a rotation lever connected to the rotation shaft of the valve body to angularly rotate the rotation shaft.

Description

Multi manifold type unit module of sample sampling apparatus and sample sampling apparatus

The present invention relates to a multi-manifold type unit module of a sample sampling device and a sample sampling device, and more particularly, to a multi-manifold type unit module and a sample sampling device for a sample sampling device that allow the number of sampling lines to be freely added. is about

In general, a conventional sample sampling device for acquiring an appropriate small amount of sample from a disposable sample bag accommodating a large amount of culture solution cultured by the culture device as needed is a plurality of sampling bags using an integrated manifold connected to the sample bag. can be distributed

Such a conventional integrated manifold is, for example, a 4-port manifold having four ports to connect four sampling lines, a five-port manifold having five ports to connect five sampling lines, etc. When manufacturing parts, an integral manifold having a predetermined number of ports was selected and used by a user as needed.

However, in the case of using an integrated manifold, which is a ready-made product whose number of ports has already been determined when manufacturing these parts, if it is necessary to add a sampling line as necessary, it is impossible to install additional sampling lines because the number of ready-made ports cannot be exceeded. Also, it was very difficult to easily remove the sampling line as needed, so there were problems in having to purchase a separate compression press or welder for cutting the tube.

In addition, even when the sampling line is removed, there are problems such as contamination propagation in which the integrated manifold, main tube, and sample bag are contaminated by the culture solution remaining in the cut tube.

In addition, since the conventional integrated manifold can only perform a function of distributing the culture medium, there are problems in that the sample cannot be distributed in an optimal state by precisely controlling the flow rate of each sampling line.

The present invention is intended to solve various problems including the above problems, and by using a multi-modular manifold that can connect a plurality of unit modules indefinitely, a sampling line can be added at any time as needed, thereby reducing the sample sampling operation. It can be done easily and, if necessary, the sampling line can be easily removed without cutting the tube, so it is possible to prevent the propagation of culture medium contamination due to tube cutting. , the flow rate or flow rate of the sampling line can be precisely controlled, and the Y-shaped luer lock member can be used to connect with syringes or other tubes according to the situation, so that the culture solution distribution line can be formed in various ways, and the culture device An object of the present invention is to provide a multi-manifold type unit module of a sample sampling device and a sample sampling device that can greatly increase convenience when used together with the device. However, these problems are exemplary, and the scope of the present invention is not limited thereto.

A multi-manifold type unit module of a sample sampling device according to an aspect of the present invention for solving the above problems includes a first path therein, and a second path and a third path branching from the first path based on a branch point. A unit module body in which is formed; a diaphragm valve member formed on a first surface of the unit module body and connected to the first path; It is formed on the second surface of the unit module body, is connected to the second path, is connected to the main tube connected to the sample bag, or is multi-connected to the diaphragm valve member of another neighboring unit module to form a multi-modular manifold a first temporary cap member for temporarily sealing the connection hole; a luer lock member formed on a third surface of the unit module body, connected to the third path, and connected to a sampling tube of the sampling bag to supply a desired amount of culture solution to the sampling bag; a valve body installed at the branch point of the unit module body and axially rotating along a rotation axis to block the first path or selectively connect the first path to the second path or the third path; and a rotation lever connected to the rotation shaft of the valve body to angularly rotate the rotation shaft.

In addition, according to the present invention, the valve body is formed in a cylindrical or spherical shape as a whole, and is formed by selecting any one or more of the first path, the second path, the third path, and combinations thereof. Portholes may be formed to be connected according to paths and rotation angles.

In addition, according to the present invention, the porthole may have a T-shape as a whole in cross section.

In addition, according to the present invention, the first temporary cap member may include: a cap head portion which is easily rotated so as to be rotated by holding it by hand or rotating with a tool; and a cap screw part connected to the cap head part and having a screw formed thereon so as to be screw-coupled to the connection hole.

Also, according to the present invention, the screw standard of the cap screw portion may coincide with the screw standard of the diaphragm screw portion formed at the front end of the diaphragm valve member.

In addition, according to the present invention, the luer lock member has a tube connection head that is sharply formed so as to be connected to the sampling tube at a tip end thereof, and a luer lock thread portion screwed with the unit module body is formed at the rear end thereof. It may be a straight luer lock member having a straight shape.

In addition, according to the present invention, the luer lock member has a tube connection head that is sharply formed so as to be connected to the sampling tube at its distal end, and a luer lock threaded portion screwed with the unit module body is formed at its rear end, It may be a Y-shaped luer lock member having an overall Y-shape in which a branch pipe is formed so as to be connected to a syringe or other connecting tube in the middle.

In addition, according to the present invention, instead of the luer lock member, a second temporary cap member formed on the third surface of the unit module body and temporarily sealing the third path; may be further included.

On the other hand, a sample sampling apparatus according to the spirit of the present invention for solving the above problems, a sample bag for accommodating a culture solution therein; a main tube connected to the sample bag; a multi-modular manifold connected to the main tube and configured of a plurality of unit modules assembled with each other to distribute the culture solution; a plurality of sampling tubes respectively connected to the unit modules; and a plurality of sampling bags respectively connected to the sampling tubes, wherein the unit module has a first path therein, and a second path and a third path branching from the first path based on a branch point. a unit module body formed; a diaphragm valve member formed on a first surface of the unit module body and connected to the first path; It is formed on the second surface of the unit module body, is connected to the second path, is connected to the main tube connected to the sample bag, or is multi-connected to the diaphragm valve member of another neighboring unit module to form a multi-modular manifold a first temporary cap member for temporarily sealing the connection hole; a luer lock member formed on the third surface of the unit module body, connected to the third path, and connected to the sampling tube of the sampling bag to supply the culture solution to the sampling bag by a desired volume; a valve body installed at the branch point of the unit module body and axially rotating along a rotation axis to block the first path or selectively connect the first path to the second path or the third path; and a rotation lever connected to the rotation shaft of the valve body to angularly rotate the rotation shaft.

According to some embodiments of the present invention made as described above, by using a multi-modular manifold capable of infinitely connecting a plurality of unit modules, a sampling line can be added at any time as needed, thereby facilitating the sample sampling operation. and, if necessary, the sampling line can be easily removed without cutting the tube, preventing the spread of culture medium contamination due to tube cutting. It can precisely control the flow rate or flow rate of It has the effect of greatly increasing convenience. Of course, the scope of the present invention is not limited by these effects.

1 is an external perspective view illustrating a multi-manifold type unit module of a sample sampling apparatus according to some embodiments of the present disclosure;
FIG. 2 is a cross-sectional view illustrating a multi-manifold type unit module of the sample sampling device of FIG. 1 .
3 is a perspective view illustrating a multi-modular manifold in which multi-manifold-type unit modules of the sample sampling device of FIG. 1 are connected to each other.
4 is a perspective view illustrating a state in which a sampling bag is connected to a multi-modular manifold in which the multi-manifold-type unit modules of the sample sampling device of FIG. 1 are connected to each other.
5 is a perspective view illustrating a multi-manifold type unit module and a sample sampling device of the sample sampling device of FIG. 1 .
6 is a front view illustrating a multi-modular manifold of the sample sampling device of FIG. 1 .
7 is a perspective view illustrating a Y-type luer lock member of the multi-manifold type unit module of the sample sampling device of FIG. 1 .
8 is a perspective view illustrating a state in which the sample sampling device of FIG. 1 is connected to the culture device.

Hereinafter, several preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

Examples of the present invention are provided to more completely explain the present invention to those of ordinary skill in the art, and the following examples may be modified in various other forms, and the scope of the present invention is as follows It is not limited to an Example. Rather, these embodiments are provided so as to more fully and complete the present disclosure, and to fully convey the spirit of the present invention to those skilled in the art. In addition, in the drawings, the thickness or size of each layer is exaggerated for convenience and clarity of description.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described with reference to the drawings schematically illustrating ideal embodiments of the present invention. In the drawings, variations of the illustrated shape can be envisaged, for example depending on manufacturing technology and/or tolerances. Accordingly, embodiments of the inventive concept should not be construed as limited to the specific shape of the region shown in the present specification, but should include, for example, changes in shape caused by manufacturing.

1 is an external perspective view illustrating a multi-manifold type unit module 100 of a sample sampling apparatus according to some embodiments of the present invention, and FIG. 2 is a multi-manifold type unit module 100 of the sample sampling apparatus of FIG. 1 . It is a cross-sectional view showing

First, as shown in FIGS. 1 and 2 , the multi-manifold type unit module 100 of the sample sampling apparatus according to some embodiments of the present invention is largely a unit module body 10 and a diaphragm valve (Septum). A valve member 20 , a first temporary cap member 30 , a luer lock member 40 , a valve body 50 , and a rotation lever 60 may be included.

For example, as shown in FIGS. 1 and 2 , the unit module body 10 has a first path P1 therein, and a second path that branches from the first path P1 based on a branching point. (P2) and the third path (P3) may be a type of building block-type structure is formed.

The unit module body 10 includes the diaphragm valve member 20 , the first temporary cap member 30 , the luer lock member 40 , the valve body 50 , and the rotary lever It may be, for example, a hexahedral block having sufficient strength and durability to support the 60 .

In addition, for example, as shown in FIGS. 1 and 2, the diaphragm valve member 20 is a one-way valve in which a kind of diaphragm is formed, the first surface 10a of the unit module body 10, That is, in the drawing, it may be a kind of connection member formed on the right side and connected to the first path P1.

More specifically, for example, as shown in FIG. 2 , the diaphragm valve member 20 has a diaphragm threaded portion 21 formed at its distal end, and a rear threaded portion screwed together with the unit module body 10 at its rear end. can be formed.

In addition, for example, as shown in FIGS. 1 and 2, the first temporary cap member 30 is formed on the second side 10b of the unit module body 10, that is, on the left side in the drawing, A multi-modular manifold ( 300) may be a kind of sealing stopper for temporarily sealing the connection hole (C) that can be formed.

More specifically, for example, as shown in FIG. 2 , the first temporary cap member 30 includes a cap head ( 30 ) that is easily rotated so as to be rotated by holding it by hand or rotating with a tool. 31) and a cap screw part 32 connected to the cap head part 31 and having a screw formed thereon to be screw-coupled to the connection hole (C).

Here, the screw standard of the cap screw part 32 may coincide with the screw standard of the diaphragm screw part 21 formed at the front end of the diaphragm valve member 20 .

Therefore, as shown in FIG. 2 , when the unit module 100 of the present invention is used alone, the connection hole C is temporarily sealed using the first temporary cap member 30 . Also, when a plurality of unit modules 100 are connected to each other, only the last unit module 100 may be left, and the rest may be multi-connected to the diaphragm valve member 20 of another unit module.

In addition, for example, as shown in FIGS. 1 and 2 , the luer lock member 40 is formed on the third surface 10c of the unit module body 10 , and is formed with the third path P3 and It may be a type of connection tab member connected to the sampling tube T2 of the sampling bag 400 so as to supply the culture solution to the sampling bag 400 by a desired capacity.

More specifically, for example, as shown in FIGS. 1 and 2 , the luer lock member 40 has a tube connection head 41 formed with a pointed tip so as to be connected to the sampling tube T2 at its tip. It may be a straight luer lock member 40-1 having a generally straight shape, and having a luer lock screw portion 42 screw-coupled to the unit module body 10 at a rear end thereof.

In addition, for example, as shown in FIG. 2 , the valve body 50 is installed at the branch point of the unit module body 10 , and blocks the first path P1 while rotating along the axis of rotation. Alternatively, it may be a kind of variable path member that selectively connects the first path P1 with the second path P2 or the third path P3.

More specifically, for example, as shown in FIG. 2 , the valve body 50 is formed in a cylindrical or spherical shape as a whole, and the first path P1 and the second path P2, A porthole H may be formed so as to be connected to the third path P3 and paths made by selecting any one or more of combinations thereof according to a rotation angle. Here, for example, the porthole (H) may be a three-way porthole having an overall T-shaped cross-section.

In addition, for example, as shown in FIGS. 1 and 2 , the rotary lever 60 may be a kind of handle member connected to the rotary shaft of the valve body 50 to angularly rotate the rotary shaft.

Accordingly, as shown in FIG. 2 , when the rotation lever 60 is rotated at a first angle using a user or a separate actuator, the first path P1 and the second path P2 are connected to each other. It is possible to supply the culture solution to the neighboring unit module 100, for example, although not shown, when the rotary lever 60 is rotated at a second angle (90 degrees to the right), the valve body 50 is rotated by 90 degrees. While rotating, the first path P1 and the third path P3 are connected to distribute the culture solution in the sampling bag direction, and the rotation lever 60 is rotated at a third angle (180 degrees to the right). ) when the valve body 50 is rotated 180 degrees, the first path (P1), the second path (P2), and the third path (P3) are all connected to each other so that the culture solution is adjacent to each other. It is possible to selectively implement the role of a three-way valve for supplying the culture solution to the unit module 100 and distributing it in the sampling bag direction at the same time.

Meanwhile, as shown in FIG. 2 , in the multi-manifold type unit module 100 of the sample sampling apparatus according to some embodiments of the present invention, the unit module body 10 instead of the luer lock member 40 is A second temporary cap member 70 formed on the third surface 10c and temporarily sealing the third path P3 may be further included.

3 is a perspective view illustrating a multi-modular manifold 300 in which the multi-manifold-type unit modules 100 of the sample sampling device of FIG. 1 are connected to each other, and FIG. 4 is a multi-manifold-type unit of the sample sampling device of FIG. 1 . A perspective view showing a state in which the sampling bag 400 is connected to the multi-modular manifold 300 in which the modules 100 are connected to each other, and FIG. 5 is the multi-manifold type unit module 100 and the sample of the sample sampling device of FIG. 1 . It is a perspective view showing the sampling device 1000 , and FIG. 6 is a front view showing the multi-modular manifold 300 of the sample sampling device 1000 of FIG. 1 .

3 to 6 , the sample sampling apparatus 1000 according to some embodiments of the present invention includes a sample bag 200 accommodating a culture solution therein, and the sample bag 200 connected to the sample bag 200 . A multi-module that may consist of a main tube (T1) and a plurality of unit modules (100) connected to the main tube (T1) and assembled with each other to distribute the culture solution to a plurality of sampling bags (400) It may include a type manifold 300 , a plurality of sampling tubes T2 respectively connected to the unit modules 100 , and a plurality of sampling bags 400 respectively connected to the sampling tubes T2 . .

Here, the unit module 100 has the same configuration and role as the multi-manifold type unit module 100 of the sample sampling device of the present invention shown in FIGS. 1 and 2 , and a detailed description thereof will be omitted. .

Therefore, as shown in FIGS. 3 to 6 , the user connects the main tube T1 to the sample bag 200 containing the large-capacity culture medium, and the unit module 100 described above in the main tube T1. ), and the sampling tube T2 and the sampling bag 400 may be connected to each of the unit modules 100 .

Then, the sample can be sampled in the desired sampling bag 400 by selectively manipulating the rotation levers 60 of the unit module 100 of the multi-modular manifold 300 as needed. The unit module 100 can be easily separated and removed.

Therefore, by using the multi-modular manifold 300 that can connect the plurality of unit modules 100 indefinitely, a sampling line can be added at any time as needed, thereby facilitating the sample sampling operation, and Therefore, the sampling line can be easily removed without cutting the tube, thereby preventing the propagation of culture medium contamination due to tube cutting. By precisely adjusting the angle, the flow rate or flow rate of the sampling line can be precisely controlled.

7 is a perspective view illustrating the Y-type luer lock member 40 - 2 of the multi-manifold type unit module 100 of the sample sampling device of FIG. 1 .

As shown in FIGS. 1 to 7 , the luer lock member 40 has a tube connection head 41 that is sharply formed so as to be connected to the sampling tube T2 at the front end, and the unit at the rear end. A Y-shaped luer lock having a Y-shape as a whole is formed with a luer lock threaded portion 42 screw-coupled to the module body 10, and a branch tube 43 is formed in the middle to be connected to a syringe S or other connecting tube. It may be a member 40-2.

Accordingly, the Y-shaped luer lock member 40-2 can be used to connect with the syringe S or other tubes according to the situation, so that a culture solution distribution line can be formed in various ways.

8 is a perspective view illustrating a state in which the sample sampling apparatus 1000 of FIG. 1 is connected to the culture apparatus 2000 in a used state.

1 to 8, the sample bag 200 is placed inside the culture apparatus 2000 capable of culturing microorganisms by heating the culture medium to a constant temperature, and the sample sampling apparatus of the present invention ( 1000) to perform sample sampling simultaneously with incubation.

Therefore, by using the sample sampling apparatus 1000 together with the culture apparatus 2000, the convenience of use can be greatly increased, and the unit modules 100 can be infinitely connected as needed, and unnecessary unit modules can be removed. This makes the sampling process very convenient.

Although the present invention has been described with reference to the embodiment shown in the drawings, which is only exemplary, those skilled in the art will understand that various modifications and equivalent other embodiments are possible therefrom. Therefore, the true technical protection scope of the present invention should be determined by the technical spirit of the appended claims.

10: unit module body
10a: first side
10b: second side
10c: 3rd side
P1: first path
P2: second path
P3: third path
20: diaphragm valve member
21: diaphragm thread part
C: connection hole
30: first temporary cap member
31: cap head
32: cap screw part
40: no luer lock
40-1: Straight luer lock member
40-2: Y-shaped luer lock member
41: tube connection head
42: Luer lock thread
43: branch pipe
S: syringe
50: valve body
60: rotary lever
H: pothole
70: second temporary cap member
100: unit module
200: sample bag
T1: main tube
T2: sampling tube
300: Multi-Modular Manifold
400: sampling bag
1000: sample sampling device
2000: incubation apparatus

Claims (9)

a unit module body in which a first path and a second path and a third path branching from the first path based on a branching point are formed therein;
It is formed on a first surface of the unit module body, is connected to the first path, a diaphragm screw is formed at the front end, and a rear screw is screwed-assembled with the unit module body is formed at the rear end, and a diaphragm is formed therein. One-way valve diaphragm valve (Septum Valve) member;
It is formed on the second surface of the unit module body, is connected to the second path, is connected to the main tube connected to the sample bag, or is multi-connected to the diaphragm valve member of another neighboring unit module to form a multi-modular manifold a first temporary cap member for temporarily sealing the connection hole;
a luer lock member formed on a third surface of the unit module body, connected to the third path, and connected to a sampling tube of the sampling bag to supply a desired amount of culture solution to the sampling bag;
a valve body installed at the branch point of the unit module body and axially rotating along a rotation axis to block the first path or selectively connect the first path to the second path or the third path; and
a rotation lever connected to the rotation shaft of the valve body to angularly rotate the rotation shaft;
A multi-manifold-type unit module of the sample sampling device comprising a. The method of claim 1,
The valve body is formed in a cylindrical or spherical shape as a whole, and according to paths and rotation angles made by selecting any one or more of the first path, the second path, the third path, and combinations thereof. A multi-manifold type unit module of a sample sampling device, in which a port hole is formed to be connected. 3. The method of claim 2,
The porthole is a multi-manifold type unit module of a sample sampling device, in which the cross-section is generally T-shaped. The method of claim 1,
The first temporary cap member,
a cap head portion that is easily rotated so as to be rotated by hand or rotated with a tool; and
a cap screw part connected to the cap head part and having a screw formed thereon so as to be screw-coupled to the connection hole;
A multi-manifold-type unit module of the sample sampling device comprising a. 5. The method of claim 4,
A multi-manifold type unit module of a sample sampling device, wherein the screw standard of the cap screw is identical to the screw standard of the diaphragm screw formed at the tip of the diaphragm valve member. The method of claim 1,
The luer lock member is
A sample sampling device, which is a straight-line luer lock member having a tube connection head that is sharply formed so as to be connected to the sampling tube at a tip end and a luer lock thread portion screwed with the unit module body is formed at the rear end. Multi-manifold type unit module. The method of claim 1,
The luer lock member is
A tube connection head that is sharply formed so as to be connected to the sampling tube is formed at the front end, and a luer lock thread screwed to the unit module body is formed at the rear end, and a branch pipe can be connected to a syringe or other connection tube in the middle. A multi-manifold type unit module of a sample sampling device, which is a Y-shaped luer lock member having a Y-shape as a whole. The method of claim 1,
a second temporary cap member formed on a third surface of the unit module body instead of the luer lock member and temporarily sealing the third path;
The multi-manifold type unit module of the sample sampling device further comprising a. a sample bag accommodating the culture medium therein;
a main tube connected to the sample bag;
a multi-modular manifold connected to the main tube and configured of a plurality of unit modules assembled with each other to distribute the culture solution;
a plurality of sampling tubes respectively connected to the unit modules; and
a plurality of sampling bags respectively connected to the sampling tubes; and
The unit module is
a unit module body in which a first path and a second path and a third path branching from the first path based on a branching point are formed therein;
It is formed on a first surface of the unit module body, is connected to the first path, a diaphragm screw is formed at the front end, and a rear screw is screwed-assembled with the unit module body is formed at the rear end, and a diaphragm is formed therein. One-way valve diaphragm valve (Septum Valve) member;
It is formed on the second surface of the unit module body, is connected to the second path, is connected to the main tube connected to the sample bag, or is multi-connected to the diaphragm valve member of another neighboring unit module to form a multi-modular manifold a first temporary cap member for temporarily sealing the connection hole;
a luer lock member formed on the third surface of the unit module body, connected to the third path, and connected to the sampling tube of the sampling bag to supply the culture solution to the sampling bag by a desired volume;
a valve body installed at the branch point of the unit module body and axially rotating along a rotation axis to block the first path or selectively connect the first path to the second path or the third path; and
a rotation lever connected to the rotation shaft of the valve body to angularly rotate the rotation shaft;
A sample sampling device comprising a.

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