KR102378298B1 - Pd-1/pdl-1 표적화 약물에 대한 반응의 평가 방법 - Google Patents
Pd-1/pdl-1 표적화 약물에 대한 반응의 평가 방법 Download PDFInfo
- Publication number
- KR102378298B1 KR102378298B1 KR1020187020429A KR20187020429A KR102378298B1 KR 102378298 B1 KR102378298 B1 KR 102378298B1 KR 1020187020429 A KR1020187020429 A KR 1020187020429A KR 20187020429 A KR20187020429 A KR 20187020429A KR 102378298 B1 KR102378298 B1 KR 102378298B1
- Authority
- KR
- South Korea
- Prior art keywords
- vhl
- cancer
- targeting
- patient
- loss
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G01N33/57484—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G01N33/57438—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15307050 | 2015-12-18 | ||
| EP15307050.3 | 2015-12-18 | ||
| PCT/EP2016/081485 WO2017103147A1 (en) | 2015-12-18 | 2016-12-16 | Method for assessing the response to pd-1/pdl-1 targeting drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180115262A KR20180115262A (ko) | 2018-10-22 |
| KR102378298B1 true KR102378298B1 (ko) | 2022-03-23 |
Family
ID=55129471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187020429A Active KR102378298B1 (ko) | 2015-12-18 | 2016-12-16 | Pd-1/pdl-1 표적화 약물에 대한 반응의 평가 방법 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11137404B2 (https=) |
| JP (1) | JP6762363B2 (https=) |
| KR (1) | KR102378298B1 (https=) |
| IL (1) | IL260024B (https=) |
| WO (1) | WO2017103147A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101980003B1 (ko) * | 2017-09-14 | 2019-05-17 | 건국대학교 글로컬산학협력단 | 면역체크포인트의 발현을 억제하기 위한 물질을 포함하는 나노입자 전달체 |
| KR102216725B1 (ko) * | 2017-12-29 | 2021-02-17 | 연세대학교 산학협력단 | 면역 항암 요법에 대한 치료 반응 예측 방법 |
| WO2019159825A1 (ja) * | 2018-02-14 | 2019-08-22 | 国立大学法人名古屋大学 | 抗pd-1抗体/抗pd-l1抗体療法の効果を予測するバイオマーカー |
| GB201805876D0 (en) * | 2018-04-09 | 2018-05-23 | Francis Crick Institute Ltd | Method |
| JP2022533012A (ja) * | 2019-04-30 | 2022-07-21 | エックスセル・バイオサイエンシズ・インコーポレイテッド | 細胞表現型を調節するための系および方法 |
| WO2020239558A1 (en) | 2019-05-24 | 2020-12-03 | Pfizer Inc. | Combination therapies using cdk inhibitors |
| TW202327595A (zh) | 2021-10-05 | 2023-07-16 | 美商輝瑞大藥廠 | 用於治療癌症之氮雜內醯胺化合物的組合 |
| WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
| KR20230125672A (ko) * | 2022-02-21 | 2023-08-29 | 사회복지법인 삼성생명공익재단 | 암 환자에 대한 면역관문억제제의 반응성 예측용 조성물 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015518826A (ja) | 2012-05-15 | 2015-07-06 | ブリストル−マイヤーズ スクイブ カンパニーBrist | Pd−1/pd−l1シグナル伝達を破壊することによる癌免疫療法 |
-
2016
- 2016-12-16 JP JP2018529539A patent/JP6762363B2/ja active Active
- 2016-12-16 US US16/061,667 patent/US11137404B2/en not_active Expired - Fee Related
- 2016-12-16 WO PCT/EP2016/081485 patent/WO2017103147A1/en not_active Ceased
- 2016-12-16 KR KR1020187020429A patent/KR102378298B1/ko active Active
-
2018
- 2018-06-14 IL IL260024A patent/IL260024B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015518826A (ja) | 2012-05-15 | 2015-07-06 | ブリストル−マイヤーズ スクイブ カンパニーBrist | Pd−1/pd−l1シグナル伝達を破壊することによる癌免疫療法 |
Non-Patent Citations (10)
| Title |
|---|
| B Beuselinck et al, Clinical Cancer Research (2015.01.12.), vol 21, no 6, pp 1329-1339. |
| Messai Yosra et al, European Urology (2015.12.23.), vol 70, no 4, pp 623-632. |
| Noman Muhammad Zaeem et al, Cancer Microenvironment (2014.10.22.), vol 7, no 3, pp 153-160. |
| P D Sutphin et al, Cancer Research (2007.06.15.), pp 5896-5905. |
| Scott Tykodi et al, Oncotargets and Therapy (2014.07.01.), pp 1349. |
| Solene Florence Kammerer Jacquet et al, International Journal of Cancer (2016.09.13.), vol 140, no 1, pp 142-148. |
| Susan A J Vaziri et al, Frontiers in Oncology (2012.05.28.), vol 2, XP055347667. |
| Y Messai et al, Cancer Research (2014.10.08.), vol 74, no 23, pp 6820-6832. |
| Yosra Messai et al, Oncoimmunology (2015.03.06.), vol 4, no 2, pp e985951. |
| Zitvogel L et al, Oncoimmunology (2012.11.01.), vol 1, no 8, pp 1223-1225. |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6762363B2 (ja) | 2020-09-30 |
| US11137404B2 (en) | 2021-10-05 |
| KR20180115262A (ko) | 2018-10-22 |
| WO2017103147A1 (en) | 2017-06-22 |
| IL260024A (en) | 2018-07-31 |
| IL260024B (en) | 2021-07-29 |
| JP2019500870A (ja) | 2019-01-17 |
| US20180364241A1 (en) | 2018-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102378298B1 (ko) | Pd-1/pdl-1 표적화 약물에 대한 반응의 평가 방법 | |
| Schuster et al. | Loss of CD20 expression as a mechanism of resistance to mosunetuzumab in relapsed/refractory B-cell lymphomas | |
| Brueckl et al. | Clinically relevant prognostic and predictive markers for immune-checkpoint-inhibitor (ICI) therapy in non-small cell lung cancer (NSCLC) | |
| Dyck et al. | Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function | |
| Lopez-Bujanda et al. | Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression | |
| Reifenberger et al. | Advances in the molecular genetics of gliomas—implications for classification and therapy | |
| Arts et al. | PDGFRB gain-of-function mutations in sporadic infantile myofibromatosis | |
| Teo et al. | Alterations in DNA damage response and repair genes as potential marker of clinical benefit from PD-1/PD-L1 blockade in advanced urothelial cancers | |
| Colle et al. | Immunotherapy and patients treated for cancer with microsatellite instability | |
| Wang et al. | The TGFβ-miR-499a-SHKBP1 pathway induces resistance to EGFR inhibitors in osteosarcoma cancer stem cell-like cells | |
| KR20190015408A (ko) | 종양을 치료하는 방법에 사용하기 위한 항-pd-1 항체 | |
| PT1994410E (pt) | Métodos e estojos para detecção precoce de cancro ou de predisposição a este | |
| Tabatabai et al. | Clinical implications of molecular neuropathology and biomarkers for malignant glioma | |
| JP2018516870A (ja) | 3つの完全ヒトモノクローナル抗egfr抗体の組み合わせを用いて上皮成長因子受容体(egfr)の細胞外ドメインに変異を有する患者を治療する方法 | |
| JP2019529437A (ja) | 抗pd−l1抗体単独療法に対する固形腫瘍の奏効性を特徴付けるための組成物および方法 | |
| Derer et al. | Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression | |
| Rogers et al. | Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities | |
| Larsen et al. | EGFR CA repeat polymorphism predict clinical outcome in EGFR mutation positive NSCLC patients treated with erlotinib | |
| Krawczyk et al. | Genetic and immune factors underlying the efficacy of cetuximab and panitumumab in the treatment of patients with metastatic colorectal cancer | |
| EP3391054B1 (en) | Method for assessing the response to pd-1/pdl-1 targeting drugs | |
| WO2022112198A1 (en) | Method to select the optimal immune checkpoint therapies | |
| Deka et al. | Multiple myeloma associated long non-coding RNA PLUM confers chemoresistance by enhancing PRC2 mediated UPR pathway activation | |
| CN121100126A (zh) | 配体依赖性辅阻遏物(lcor)的突变体及其用途 | |
| EP4499875A1 (en) | Biomarkers of il7r modulator activity | |
| Cen et al. | Biomarkers in oncology and nephrology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| A201 | Request for examination | ||
| A302 | Request for accelerated examination | ||
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PA0302 | Request for accelerated examination |
St.27 status event code: A-1-2-D10-D17-exm-PA0302 St.27 status event code: A-1-2-D10-D16-exm-PA0302 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| P22-X000 | Classification modified |
St.27 status event code: A-4-4-P10-P22-nap-X000 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| P22-X000 | Classification modified |
St.27 status event code: A-4-4-P10-P22-nap-X000 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE) Year of fee payment: 5 |