KR102365348B1 - An apparatus and method for measuring proton dose distribution using prompt gamma iamge and positron emission romograpfy and pet measurement system - Google Patents

Abstract

The present invention relates to an apparatus and method for measuring proton dose distribution in the body, and more particularly, to a measuring apparatus and method capable of measuring a proton dose distribution in the body using an immediate gamma ray image and a positron emission tomography image.

Description

AN APPARATUS AND METHOD FOR MEASURING PROTON DOSE DISTRIBUTION USING PROMPT GAMMA IAMGE AND POSITRON EMISSION ROMOGRAPFY AND PET MEASUREMENT SYSTEM

The present invention relates to an apparatus and method for measuring proton dose distribution in the body, and more particularly, to a measuring apparatus and method capable of measuring a proton dose distribution in the body using an immediate gamma ray image and a positron emission tomography image.

Radiation therapy is one of the three major cancer treatment methods along with surgery and chemotherapy using chemotherapy. .

Radiation therapy is broadly divided into two areas: external radiation therapy, which treats cancer by irradiating high-energy X-rays or gamma rays, protons, or heavy ion particles from the outside, and brachytherapy, which treats cancer by injecting radioactive isotopes into the body. there is.

In particular, during external radiation therapy, proton therapy refers to a method of accelerating protons, which are atomic hydrogen nuclei, to increase energy and then irradiating them to the patient's tumor location. It shows a dose characteristic (Bragg Peak) that transfers most of the energy to the surrounding material.

The specific depth through which most of the energy is delivered is determined according to the initial energy of the accelerated proton, and the SOBP (Spread Out (SOBP) Treatment is performed by creating a Bragg Peak).

Unlike the most common radiation therapy using X-rays, which deliver the maximum dose near the skin and the delivered dose gradually decreases as it goes deep into the body, proton therapy can reduce the dose delivered to normal tissues, so It has the advantage of reducing the incidence of secondary cancer.

On the other hand, as confirmed in FIG. 1, in the case of X-rays, only a 3% dose difference occurs for a depth error of 1 cm, but in the case of a proton beam, a dose difference of up to 90% can occur for the same depth error. Given this, it is very important to accurately predict the dose drop point (or irregularity) of the proton beam in proton therapy.

That is, if the point of sharp drop in the dose of the proton beam is not accurately predicted due to errors occurring in the beam delivery device, treatment plan, patient setup, etc., the planned dose may not be delivered to the cancer tissue, or excessive dose may be delivered to surrounding major organs. there is.

Therefore, there is a need for an apparatus and method capable of accurately confirming in real time the drop point of the actually delivered proton dose in the patient's body.

On the other hand, the following prior art literature discloses a technology for a PET-MRI fusion system, but does not disclose the technical gist of the present invention.

Korean Patent Publication No. 10-2010-0060193

A method for measuring a proton dose distribution in the body using an instantaneous gamma-ray image and a positron emission tomography image according to an embodiment of the present invention has the following object in order to solve the above-mentioned problems.

A device and method for measuring proton dose distribution in the body that can prevent the problem of failing to deliver the planned dose to cancer tissue during proton treatment or delivering excessive dose to surrounding major organs by accurately determining the point of sharp drop in the proton dose in the patient's body will provide

The problems to be solved of the present invention are not limited to those mentioned above, and other problems not mentioned will be clearly understood by those of ordinary skill in the art from the following description.

The apparatus for measuring the proton dose distribution in the body using the instantaneous gamma-ray image and the positron emission tomography image according to an embodiment of the present invention is disposed inside the gantry and detects at least one of the instantaneous gamma-ray and the positron emitter generated by the proton beam, , a detection module comprising a plurality of detectors; a collimator module including a plurality of collimators formed to be detachably attached to the front end of the detector; and a control module for measuring the proton dose distribution in the body of the subject based on the instantaneous gamma rays and positron emitters detected by the detection module.

Preferably, the collimator module includes a transfer unit coupled to a side surface of the collimator, and the transfer unit is formed to move on a transfer rail formed along the longitudinal direction of the gantry.

The detection module includes a plurality of detectors arranged in an annular shape, the collimator module includes a plurality of collimators corresponding to the plurality of detectors and a support ring for supporting the plurality of collimators, the support ring is the gantry It is preferable to be configured to be rotatable within.

The detection module detects instantaneous gamma rays generated by the proton beam while the collimator is attached to the front end of the detector while the proton beam is irradiated, and after the proton beam is irradiated, the collimator is the detector It is preferable to detect the positron emitter generated by the proton beam in a state that is removed from the front end of the .

Preferably, the collimator is a parallel porous type collimator in which a plurality of collimator holes are arranged to be spaced apart from each other at a preset interval.

The detector may include: a scintillator configured by combining and arranging a plurality of scintillation crystal cells having a polygonal columnar shape; a photoelectric conversion unit coupled to one end of the scintillator to convert the flash signal transmitted from the scintillator into an electrical signal and output it; and a detection circuit unit that is electrically connected to the photoelectric conversion unit and converts the electrical signal transmitted from the photoelectric conversion unit into data through a preset detection algorithm and transmits it to the control module.

The control module may include: a first acquisition unit receiving the instantaneous gamma-ray detection information from the detection module; a second acquisition unit receiving the detection information of the positron emitter from the detection module; an instantaneous gamma-ray image generator for generating an instantaneous gamma-ray image based on the instantaneous gamma-ray detection information; a positron emission tomography image generator for generating a positron emission tomography image based on the detection information of the positron emitter; and a proton dose distribution information generating unit that calculates proton dose distribution information based on the instantaneous gamma ray image and the positron emission tomography image.

The control module further includes a preprocessing unit that performs preprocessing for reducing noise caused by background radiation among the instantaneous gamma-ray detection information acquired by the first acquiring unit, wherein the instantaneous gamma-ray image generator is It is preferable to generate an instantaneous gamma-ray image based on it.

The method for measuring a proton dose distribution in the body using an instantaneous gamma-ray image and a positron emission tomography image according to an embodiment of the present invention is disposed inside a gantry to detect at least one of instantaneous gamma rays and positron emitters generated by a proton beam, , a detection module including a plurality of detectors, a collimator module including a plurality of collimators detachably formed at the front end of the detector, and the instantaneous gamma rays and positron emitters detected by the detection module. It relates to a method for measuring proton dose distribution in the body using an instantaneous gamma ray image and positron emission tomography image applied to a proton dose distribution measuring apparatus in the body including a control module for measuring proton dose distribution in the body, wherein the collimator is attached to the front end of the detector moving the collimator module by the control module so as to be possible; irradiating the proton beam to a subject disposed inside the gantry; detecting, by the detection module, instantaneous gamma rays generated by the proton beam; stopping the irradiation of the proton beam and moving the collimator module by the control module so that the collimator is separated from the front end of the detector; and detecting, by the detection module, the positron emitter generated by the proton beam.

Preferably, the collimator module includes a transfer unit coupled to a side surface of the collimator, and the transfer unit is formed to move on a transfer rail formed along the longitudinal direction of the gantry.

The detection module includes a plurality of detectors arranged in an annular shape, the collimator module includes a plurality of collimators corresponding to the plurality of detectors and a support ring for supporting the plurality of collimators, the support ring is the gantry It is preferable to be configured to be rotatable within.

Preferably, the collimator is a parallel porous type collimator in which a plurality of collimator holes are arranged to be spaced apart from each other at a preset interval.

The detector includes: a scintillator composed of a plurality of scintillation crystal cells having a polygonal columnar shape, arranged in N horizontal and M vertical arrays; a photoelectric conversion unit coupled to one end of the scintillator to convert the flash signal transmitted from the scintillator into an electrical signal and output it; and a detection circuit unit that is electrically connected to the photoelectric conversion unit and converts the electrical signal transmitted from the photoelectric conversion unit into data through a preset detection algorithm and transmits it to the control module.

detecting, by the detection module, the positron emitter generated by the proton beam; Thereafter, the method further includes, by the control module, generating proton dose distribution information of the subject based on the instantaneous gamma rays and positron emitters detected by the detection module.

The control module may include: a first acquisition unit receiving the instantaneous gamma-ray detection information from the detection module; a second acquisition unit receiving the detection information of the positron emitter from the detection module; an instantaneous gamma-ray image generator for generating an instantaneous gamma-ray image based on the instantaneous gamma-ray information; a positron emission tomography image generator for generating a positron emission tomography image based on the detection information of the positron emitter; and a proton dose distribution information generating unit that calculates proton dose distribution information based on the instantaneous gamma ray image and the positron emission tomography image.

generating proton dose distribution information in the body of the subject; generating, by the instantaneous gamma-ray image generator, an instantaneous gamma-ray image based on the instantaneous gamma-ray information; acquiring, by the second acquiring unit, detection information of the positron emitter; generating, by the positron emission tomography image generation unit, a positron emission tomography image based on the detection information of the positron emitter; and calculating, by the proton dose distribution information generating unit, proton dose distribution information based on the instantaneous gamma ray image and the positron emission tomography image.

The control module further includes a preprocessing unit that performs preprocessing for reducing noise caused by background radiation among the instantaneous gamma-ray detection information acquired by the first acquiring unit, wherein the instantaneous gamma-ray image generator is It is preferable to generate an instantaneous gamma-ray image based on it.

Preferably, the method further includes, between the obtaining of the instantaneous gamma-ray detection information and the generating of the instantaneous gamma-ray image, the pre-processing step of preprocessing the instantaneous gamma-ray detection information by the preprocessor.

The apparatus and method for measuring the proton dose distribution in the body using the instantaneous gamma-ray image and the positron emission tomography image according to an embodiment of the present invention is the instantaneous gamma-ray distribution measurement that has been studied to precisely check the radiation dose distribution in the patient's body in the field of proton therapy. By proposing a measurement technology that can simultaneously apply the PET scan method and the PET scan method, the effect of accurately confirming the dose drop point and the three-dimensional dose distribution can be expected.

The effects of the present invention are not limited to those mentioned above, and other effects not mentioned will be clearly understood by those of ordinary skill in the art from the following description.

1 is a graph showing the dose distribution of an X-ray beam and a proton beam for treatment according to the depth of water, and the change in dose of the X-ray and proton beam with respect to a 1 cm depth error.
FIG. 2 is an image reconstructed through PET of a proton dose distribution and a distribution of a positron emitter generated by the same beam.
3 is a graph showing the distribution of doses by proton beams of 80, 150, and 220 MeV energy and the distribution of instantaneous gamma rays generated by each proton beam according to depth.
4 and 5 are conceptual diagrams of an apparatus for measuring proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image according to an embodiment of the present invention.
6 is an exploded perspective view illustrating a detailed configuration of a detector among the configurations of an apparatus for measuring proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image according to an embodiment of the present invention.
7 is a perspective view of a collimator in the configuration of an apparatus for measuring proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image according to an embodiment of the present invention.
8 to 11 are conceptual diagrams illustrating various embodiments of a structure for attaching and detaching a collimator in an apparatus for measuring proton dose distribution in the body using an instant gamma ray image and a positron emission tomography image according to an embodiment of the present invention.
12 is a block diagram illustrating a detailed configuration of a control module in the configuration of an apparatus for measuring a proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image according to an embodiment of the present invention.
13 is a flowchart illustrating a method for measuring a proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image according to an embodiment of the present invention in time series.
FIG. 14 is a flowchart illustrating detailed steps of generating proton dose distribution information in the body of a subject among the steps of FIG. 13 .

A preferred embodiment according to the present invention will be described in detail with reference to the accompanying drawings, but the same or similar components are assigned the same reference numerals regardless of reference numerals, and redundant description thereof will be omitted.

In addition, in the description of the present invention, if it is determined that a detailed description of a related known technology may obscure the gist of the present invention, the detailed description thereof will be omitted. In addition, it should be noted that the accompanying drawings are only for easy understanding of the spirit of the present invention, and should not be construed as limiting the spirit of the present invention by the accompanying drawings.

Positron emission tomography technology was first proposed in 1978, and using the principle that two extinction photons are emitted in a 180 degree direction when positrons generated from a positron emitter combine with negative electrons in the surrounding medium, numerous extinction radiation Based on the trajectory of the three-dimensional positron emitter distribution can be imaged.

The proton beam generates positron emitters such as ¹⁵ O, ¹¹ C, and ¹³ N through a nuclear reaction with ¹⁶ O, ¹² C, and ¹⁴ N, which are the main atoms constituting the human body.

Since the generated positron emitter decays with a short half-life of 2 to 20 minutes, measurement must be performed immediately after treatment, and the three-dimensional distribution of the proton dose can be inferred through the measured distribution of the positron emitter.

However, since this positron emission tomography technique does not have a direct correlation between the positron emitter distribution and the proton dose, as shown in FIG. there is.

On the other hand, nucleons placed in an excited state through a nuclear reaction with protons emit high-energy gamma rays of the MeV unit within a short period of time, which is called immediate gamma rays. With this high characteristic, it has the advantage of being able to precisely identify the point of sharp drop in dose.

3 shows the correlation between the distribution of doses delivered to the body by the proton beam (solid red line) and the generation distribution of instantaneous gamma rays (solid black line), which differs according to the energy of the proton beam. There is a lack of a system capable of measuring high-energy instantaneous gamma rays with high efficiency and high resolution for non-deterministic verification of the beam, and there is a problem in that it is difficult to obtain the dose distribution in three dimensions.

The apparatus for measuring proton dose distribution in the body using instantaneous gamma ray imaging and positron emission tomography according to an embodiment of the present invention is a measuring device capable of fusion of the advantages of the two technologies described above. It is a device that can accurately measure the proton dose distribution in a patient in real time by fusing the instant gamma-ray image that can be confirmed and the positron emission tomography image that can confirm the three-dimensional range of the proton beam.

In order to implement the above-described function, the apparatus for measuring the proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image according to an embodiment of the present invention is a detection module 100 and a collimator module as shown in FIGS. 4 and 5 . 200 and the control module 300 is configured to include.

The detection module 100 is disposed inside the gantry and performs a function of detecting at least one of immediate gamma rays and positron emitters generated by the proton beam, and the detection module 100 includes a plurality of detectors 110 . It is preferably configured such that the detection module 110 is arranged in an annular shape around the object 10 to be inspected.

Meanwhile, each detector 110 may be configured to include a scintillator 111 , a photoelectric conversion unit 112 , and a detection circuit unit 113 as shown in FIG. 6 .

The scintillator 111 is configured by combining a plurality of scintillation crystal cells having a polygonal columnar shape, and the photoelectric conversion unit 112 is coupled to one end of the scintillator 111 to provide a flash signal transmitted from the scintillator 111 . It is a configuration that converts and outputs an electrical signal.

The detection circuit unit 113 is electrically connected to the photoelectric conversion unit 112 and converts the electrical signal transmitted from the photoelectric conversion unit 112 into data through a preset detection algorithm and transmits it to the control module 300 . is a configuration that

The collimator module 200 is configured to include a plurality of collimators 210 that are formed to be detachably attached to the front end of the detector 110 , and the collimator 210 has a plurality of collimator holes 211 as shown in FIG. 7 . It is preferable that the parallel porous type collimators are spaced apart and arranged at a predetermined interval.

On the other hand, as shown in FIG. 4 , the instantaneous gamma ray should be detected while the proton beam is irradiated. At this time, since a lot of background radiation is generated, the accuracy of the measurement may not be guaranteed. In a state where the 210 is attached to the front end of the detector 110, the instantaneous gamma rays generated by the proton beam must be detected.

After the irradiation of the proton beam is completed, as shown in FIG. 5 , the positron emitter generated by the proton beam is detected while the collimator 210 is removed from the front end of the detector 110 .

That is, the collimator module 200 should be configured to be movable inside the gantry according to the detection time of the instantaneous gamma ray and the detection time of the positron emitter. Consider two implementations for the movement of the collimator module 200. can

In the case of the first embodiment, in the embodiment shown in FIGS. 8 and 9 , the collimator module 200 includes a transfer unit 220 coupled to a side surface of the collimator 210 , and the transfer unit 220 is a gantry on the inner circumferential surface of the gantry. It may be configured to be movable on the transfer rail 20 formed along the longitudinal direction of the.

That is, when irradiating the positron beam, the collimator 210 is disposed at the front end of the detector 110 as shown in FIG. 8 , so that the detector 110 detects the instantaneous gamma ray. As described above, the collimator 210 is removed from the front end of the detector 110 by the driving of the transfer unit 220 , and at this time, the detector 110 detects a positron emitter from the subject 10 .

In the case of the second embodiment, in the embodiment shown in FIGS. 10 and 11 , the detection module 100 is configured to include a plurality of detectors 110 arranged in an annular shape, and the collimator module 200 includes a plurality of detectors 110 . ) may be configured to include a plurality of collimators 210 corresponding to and a support ring 230 for supporting the plurality of collimators 210 .

The support ring 230 is rotatably disposed inside the gantry, and when the positron beam is irradiated, the collimator 210 is disposed at the front end of the detector 110 as shown in FIG. However, in a state in which irradiation of the positron beam is completed, as shown in FIG. 11 , the support ring 230 rotates so that the collimator 210 is removed from the front end of the detector 110 , in which case the detector 110 is the subject. The positron emitter from (10) is detected.

The control module 300 is configured to measure the proton dose distribution in the body of the subject 10 based on the instantaneous gamma rays and positron emitters detected by the detection module 100, and as shown in FIG. 7 , the first acquisition It is configured to include a unit 310 , a second acquisition unit 320 , an immediate gamma ray image generation unit 330 , a positron emission tomography image generation unit 340 , and a proton dose distribution information generation unit 350 .

The first acquirer 310 performs a function of receiving immediate gamma-ray detection information from the detection module 100 , and the second acquirer 320 receives the detection information of the positron emitter from the detection module 100 . carry out

The instantaneous gamma-ray image generator 330 performs a function of generating an immediate gamma-ray image based on the instantaneous gamma-ray detection information acquired by the first acquirer 310, and the positron emission tomography image generator 340 acquires the second The unit 320 performs a function of generating a positron emission tomography image based on the acquired detection information of the positron emitter.

The proton dose distribution information generator 350 calculates proton dose distribution information based on the instantaneous gamma-ray image and the positron emission tomography image generated by the instantaneous gamma-ray image generator 330 and the positron emission tomography image generator 340, respectively. perform the function

On the other hand, when the high-energy proton beam interacts with the medium of the subject 10, not only immediate gamma rays or positron emitters, but also a lot of background radiation such as neutrons, alpha, beta, and gamma rays independent of the dose distribution are generated.

Since PET images measuring the distribution of positron emitters are measured after proton beam irradiation, there is relatively little background radiation, whereas immediate gamma-ray measurement is performed during proton beam irradiation, so pretreatment of background radiation, which is noise, is required.

Accordingly, the control module 300 may further include a preprocessing unit 360 that performs preprocessing for reducing noise caused by background radiation among the instantaneous gamma ray detection information acquired by the first acquiring unit 310 . It is preferable that the sex image generator 330 generates an immediate gamma-ray image based on the pre-processed immediate gamma-ray information.

Hereinafter, a method for measuring a proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image according to an embodiment of the present invention will be described with reference to FIGS. 13 and 14 .

The method for measuring the proton dose distribution in the body using the instantaneous gamma-ray image and the positron emission tomography image according to an embodiment of the present invention is to measure the proton dose distribution in the body using the instantaneous gamma-ray image and the positron emission tomography image according to the embodiment of the present invention described above. As a method for measuring the proton dose distribution in the body using the device, the details of the proton dose distribution measuring device in the body have been described above, so the detailed description thereof will be omitted.

The method for measuring the proton dose distribution in the body using the instantaneous gamma ray image and the positron emission tomography image according to an embodiment of the present invention, first as shown in FIG. 13, a control module ( 300) The step of moving the collimator module 100 is performed first.

Thereafter, the step of irradiating the proton beam to the subject disposed inside the gantry (S200) and the step of detecting the instantaneous gamma rays generated by the proton beam by the detection module 100 (S300) are sequentially performed.

After that, the control module 300 moves the collimator module 200 so that the irradiation of the proton beam is stopped and the collimator 210 is removed from the front end of the detector 110 (S400) and the detection module 200 is applied to the proton beam. The step (S500) of detecting the positron emitter generated by the method is sequentially performed.

Finally, the control module 300 generates proton dose distribution information in the body of the subject 10 based on the instantaneous gamma rays and positron emitters detected by the detection module 100 (S600) is performed. The step of generating proton dose distribution information in the body (S600) can be subdivided into specific steps as shown in FIG. 14 .

First, the first acquisition unit 310 acquires the instantaneous gamma-ray detection information (S610), and the preprocessor 360 pre-processes the instantaneous gamma-ray detection information (S6200 and the instantaneous gamma image generator 330) acquires the first A step (S3630) of generating, by the unit 310, the instantaneous gamma-ray image based on the acquired instantaneous gamma-ray detection information is performed.

Thereafter, the second acquisition unit 320 acquires the detection information of the positron emitter (S640), and the positron emission tomography image generator 340 acquires the positron emitter detection information obtained by the second acquirer 320 A step (S650) of generating a positron emission tomography image based on the

Finally, the dose distribution information generating unit 350 calculating the proton dose distribution information based on the instantaneous gamma ray image and the positron emission tomography image (S660) is performed.

The apparatus and method for measuring the proton dose distribution in the body using the instantaneous gamma-ray image and the positron emission tomography image according to an embodiment of the present invention described above is a three-dimensional proton beam at the same time as the distribution of instantaneous gamma-rays that enable precise identification of the point of sharp drop in dose. It is a fusion technology that can simultaneously acquire PET images showing the dose distribution of

The embodiments described in this specification and the accompanying drawings are merely illustrative of some of the technical ideas included in the present invention. Therefore, since the embodiments disclosed in the present specification are for explanation rather than limitation of the technical spirit of the present invention, it is obvious that the scope of the technical spirit of the present invention is not limited by these embodiments. Modifications and specific embodiments that can be easily inferred by a person of ordinary skill in the art within the scope of the technical idea included in the specification and drawings of the present invention are included in the scope of the present invention. will have to be interpreted.

100: detection module
200: collimator module
300: control module

Claims (18)

a detection module disposed inside the gantry to detect at least one of immediate gamma rays and positron emitters generated by the proton beam, the detection module including a plurality of detectors;
a collimator module including a plurality of collimators formed to be detachably attached to the front end of the detector; and
a control module for measuring a proton dose distribution in the body of the subject based on the instantaneous gamma rays and positron emitters detected by the detection module;
includes,
The collimator module includes a transfer unit coupled to the side of the collimator,
The transfer unit is formed to move on a transfer rail formed along the longitudinal direction of the gantry,
The control module is
a first acquisition unit receiving the instantaneous gamma-ray detection information from the detection module;
a second acquisition unit receiving the detection information of the positron emitter from the detection module;
an instantaneous gamma-ray image generator for generating an instantaneous gamma-ray image based on the instantaneous gamma-ray detection information;
a positron emission tomography image generator for generating a positron emission tomography image based on the detection information of the positron emitter; and
a proton dose distribution information generating unit for calculating proton dose distribution information based on the instantaneous gamma ray image and the positron emission tomography image;
A device for measuring proton dose distribution in the body using instantaneous gamma ray imaging and positron emission tomography, including a.
delete The method according to claim 1,
The detection module includes a plurality of detectors arranged in an annular shape,
The collimator module includes a plurality of collimators corresponding to the plurality of detectors and a support ring for supporting the plurality of collimators,
The support ring is an apparatus for measuring proton dose distribution in the body using an immediate gamma ray image and a positron emission tomography image, which is configured to be rotatable within the gantry.
The method according to claim 1, wherein the detection module,
While the proton beam is irradiated, the collimator detects instantaneous gamma rays generated by the proton beam while the collimator is attached to the front end of the detector;
After the irradiation of the proton beam is completed, an apparatus for measuring proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image for detecting a positron emitter generated by the proton beam in a state in which the collimator is removed from the front end of the detector .
The method according to claim 1,
The collimator is an apparatus for measuring proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image, which is a parallel porous collimator in which a plurality of collimator holes are arranged to be spaced apart at a preset interval.
The method according to claim 1, wherein the detector,
a scintillator comprising a plurality of scintillation crystal cells having a polygonal columnar shape combined and arranged;
a photoelectric conversion unit coupled to one end of the scintillator to convert the flash signal transmitted from the scintillator into an electrical signal and output; and
a detection circuit unit electrically connected to the photoelectric conversion unit, converting an electrical signal transmitted from the photoelectric conversion unit into data through a preset detection algorithm, and transmitting it to the control module;
A device for measuring proton dose distribution in the body using instantaneous gamma ray imaging and positron emission tomography, including a.
delete The method according to claim 1,
The control module further includes a pre-processing unit for performing pre-processing for reducing noise caused by background radiation among the instantaneous gamma-ray detection information acquired by the first acquiring unit;
The instantaneous gamma-ray image generator generates an instantaneous gamma-ray image based on the preprocessed instantaneous gamma-ray detection information.
It is disposed inside the gantry, detects at least one of the instantaneous gamma rays and the positron emitter generated by the proton beam, and includes a detection module including a plurality of detectors, and a plurality of collimators formed to be detachably attached to the front end of the detector. The instantaneous gamma-ray image and positron applied to an apparatus for measuring proton dose distribution in the body, comprising: a collimator module to In the method for measuring proton dose distribution in the body using emission tomography,
moving the collimator module by the control module so that the collimator is attached to the front end of the detector;
irradiating the proton beam to a subject disposed inside the gantry;
detecting, by the detection module, instantaneous gamma rays generated by the proton beam;
stopping the irradiation of the proton beam and moving the collimator module by the control module so that the collimator is separated from the front end of the detector; and
detecting, by the detection module, the positron emitter generated by the proton beam;
A method for measuring proton dose distribution in the body using instantaneous gamma-ray imaging and positron emission tomography, comprising:
10. The method of claim 9,
The collimator module includes a transfer unit coupled to the side of the collimator,
A method for measuring proton dose distribution in the body using an instantaneous gamma ray image and a positron emission tomography image, wherein the transfer unit is formed to move on a transfer rail formed along the longitudinal direction of the gantry.
10. The method of claim 9,
The detection module includes a plurality of detectors arranged in an annular shape,
The collimator module includes a plurality of collimators corresponding to the plurality of detectors and a support ring for supporting the plurality of collimators,
The support ring is a method for measuring proton dose distribution in the body using an immediate gamma ray image and a positron emission tomography image, which is configured to be rotatable within the gantry.
10. The method of claim 9,
The collimator is a parallel porous collimator in which a plurality of collimator holes are arranged to be spaced apart from each other at a preset interval.
The method according to claim 9, wherein the detector,
a scintillator comprising a plurality of scintillation crystal cells having a polygonal columnar shape and arranged in N horizontal and M vertical arrays;
a photoelectric conversion unit coupled to one end of the scintillator to convert the flash signal transmitted from the scintillator into an electrical signal and output; and
a detection circuit unit electrically connected to the photoelectric conversion unit, converting an electrical signal transmitted from the photoelectric conversion unit into data through a preset detection algorithm, and transmitting it to the control module;
A method for measuring proton dose distribution in the body using instantaneous gamma-ray imaging and positron emission tomography, comprising:
10. The method of claim 9,
detecting, by the detection module, the positron emitter generated by the proton beam; After that,
generating, by the control module, information on the proton dose distribution in the body of the subject based on the instantaneous gamma rays and the positron emitters detected by the detection module;
Method for measuring proton dose distribution in the body using instantaneous gamma ray imaging and positron emission tomography image further comprising a.
The method according to claim 14, wherein the control module,
a first acquisition unit receiving the instantaneous gamma-ray detection information from the detection module;
a second acquisition unit receiving the detection information of the positron emitter from the detection module;
an instantaneous gamma-ray image generator for generating an instantaneous gamma-ray image based on the instantaneous gamma-ray detection information;
a positron emission tomography image generator for generating a positron emission tomography image based on the detection information of the positron emitter; and
a proton dose distribution information generating unit for calculating proton dose distribution information based on the instantaneous gamma ray image and the positron emission tomography image;
A method for measuring proton dose distribution in the body using instantaneous gamma-ray imaging and positron emission tomography, comprising:
The method according to claim 15, generating the proton dose distribution information in the body of the subject;
obtaining, by the first obtaining unit, the instantaneous gamma-ray detection information;
generating, by the instantaneous gamma-ray image generator, an instantaneous gamma-ray image based on the instantaneous gamma-ray detection information;
acquiring, by the second acquiring unit, detection information of the positron emitter;
generating, by the positron emission tomography image generation unit, a positron emission tomography image based on the detection information of the positron emitter; and
calculating, by the proton dose distribution information generating unit, proton dose distribution information based on the instantaneous gamma ray image and the positron emission tomography image;
A method for measuring proton dose distribution in the body using instantaneous gamma-ray imaging and positron emission tomography, comprising:
17. The method of claim 16,
The control module further includes a pre-processing unit for performing pre-processing for reducing noise caused by background radiation among the instantaneous gamma-ray detection information acquired by the first acquiring unit;
The instantaneous gamma-ray image generator generates an instantaneous gamma-ray image based on the preprocessed instantaneous gamma-ray detection information. A method for measuring proton dose distribution in the body using an instantaneous gamma-ray image and a positron emission tomography image.
The method according to claim 17, wherein between the step of obtaining the instantaneous gamma-ray detection information and the step of generating the instantaneous gamma-ray image,
pre-processing, by the pre-processing unit, the instantaneous gamma-ray detection information;
Method for measuring proton dose distribution in the body using instantaneous gamma ray imaging and positron emission tomography image further comprising a.

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