KR102361403B1 - Eco-friendly building interior materials comprising white clay and diatomite and manufacturing method thereof - Google Patents

Abstract

The present invention relates to an eco-friendly building interior material containing white clay and diatomaceous earth as main raw materials, and to a method for manufacturing the same.
The interior material for construction including white clay and diatomaceous earth provided in the present invention contains white clay as a main raw material of 40 wt% or more and has the unique effect of white clay, so it can provide humidity control, non-combustibility, deodorizing effect or antibacterial effect, In fact, if you live in a building constructed with the interior material for construction, the expression level of inflammatory cytokines is inhibited and the skin regeneration effect is excellent, so it can provide an effect of alleviating itching, particularly atopic itch.

Description

Eco-friendly building interior materials comprising white clay and diatomite and manufacturing method thereof;

The present invention relates to an interior material for eco-friendly construction comprising white clay and diatomaceous earth as main raw materials, and a manufacturing method thereof. Specifically, by providing an interior material for construction containing 5 to 20% of diatomaceous earth while including 40% by weight or more of white clay as a main raw material, it can be used as a building material to provide the effect of alleviating the atopic symptoms of residents.

With recent rapid growth, the number of patients with pruritus of unknown cause is continuously increasing due to social environmental changes such as urbanization, modernization, and environmental pollution. Itching or pruritus is defined as an unpleasant sensation that causes the urge to scratch or rub the skin. It is a phenomenon. It is also known as the main symptom of patients with skin diseases such as atopic dermatitis, psoriasis, and contact dermatitis or those with sensitive skin. It is known that itch is caused by activation of specific immune cells (T cells, macrophages, etc.) in the body and various cytokines (TNF-a, IL-2, etc.) induce the secretion of histamine, a mediator of itch. Often, itching is an important symptom of systemic diseases, and it is difficult to control because it is caused by multifactorial symptoms that have both pruritus and neurological elements, such as dry skin. It is a factor that seriously degrades the quality. In particular, in atopic dermatitis, itch is the most important symptom, and it is known to cause aggravation of symptoms due to the itch-scratch-inflammation vicious cycle. After using the same cleaning agent, there is an increasing number of people with sensitive skin who complain of itching sensationally in addition to the visible irritation. However, it is difficult to identify the exact mechanism of the cause of pruritus, and thus, adequate treatment for pruritus is insufficient.

Recently, thanks to the development of neurophysiological research techniques and molecular biology, many facts about the occurrence and transmission mechanism of itch have been revealed. In general, pruritus is transmitted to the afferent nerves through the noxious sensory phase of the C-fiber terminal, and pruritogen secreted from the C-fiber terminal, substance P (substance P), CGRP (calcitonin-gene related peptide), etc. is known to trigger itch by binding to respective receptors, and these fururitogens are reported to induce the release of histamine, another mediator of itch, by activating mast cells. These research results suggest a new treatment in the future, but an effective treatment is still lacking, and only various topical anti-inflammatory drugs are suggested. In addition, due to the complex and multi-layered mechanism of development of pruritus, an accurate diagnosis and development of a treatment for pruritus have not yet been achieved.

Currently used pruritus treatment regimens are topical and systemic drugs, steroids, antihistamines, immunosuppressants, and the like are used. Most topical antipruritic agents are salicylic acid (anti-inflammatory), camphor, menthol, H1 antihistamine (dyphenhydramine), local anesthetic (cinchocaine), glycyrrhizic acid, enoxolone (18 -beta glycyrrhetinic acid), calamine ((ZnOH)2SiO3, non-specific skin soothing agent), crotamiton (mite insecticide), and phenol. However, the above topical antipruritic agents are very insufficient to effectively suppress intractable itch caused by a complex entanglement of various causes, such as allergic reactions, neurostimulation reactions, and immune reactions, like the itch of atopic dermatitis. For this reason, up to now, adrenocortical steroids that reduce itch secondaryly by non-specifically and strongly suppressing the inflammatory and immune responses of the skin have been widely used for their antipruritic effect. However, corticosteroids are not fundamentally a direct antipruritic agent, and when used, they are effective and safe for short-term treatment of 2 to 4 weeks, but long-term treatment for more than 1 year cannot guarantee stability and effectiveness. Long-term use causes serious side effects such as resistance development, skin atrophy, dilated striatum, metabolic abnormalities, skin discoloration, skin thinnig, and stretch marks. do. In addition, itching inhibitory or alleviating ingredients cause problems of drowsiness or decreased immunity when administered orally, and when administered locally, safety for the skin is a problem, and when formulated in a composition for skin, most of them have problems in terms of formulation stability, so their use is limited. have.

Ultimately, the goal of treatment for itch is to stop the symptoms, and therefore, not only the development of an antipruritic agent that can effectively control intractable itch but also the creation of an environment is important, and the discovery of candidate substances for creating an environment for this is the first step. Instead of synthetic drugs, which have the disadvantages of inducing resistance due to long-term use and causing diseases that cannot be treated with a single active ingredient, interest in materials that can provide an optimal environment is growing.

Republic of Korea Patent No. 10-0758736 relates to “synthetic resin composition and panel containing phyllite powder and manufacturing method thereof”, and by containing phyllite powder, it can help the metabolism of the human body and provide antibacterial effects. It can remove harmful environmental factors.

However, research on an environmental composition capable of improving harmful environmental factors that directly affect the skin of the human body and the like is still in demand.

The present inventors have endeavored to provide a composition that can effectively control intractable itch and can be directly applied when creating a living environment. As a result, when white clay and diatomaceous earth are included, it is possible to effectively improve itching caused by various causes, such as atopy. Confirmed and completed the present invention.

In addition, the present invention has completed the manufacturing method of interior materials for construction that retains the natural eco-friendly effect of white clay by optimizing the press method of molding without applying heat and then naturally drying without heat drying while containing 40% by weight or more of white clay as a main raw material. .

Accordingly, an object of the present invention is to provide an eco-friendly interior material for construction using white clay and diatomaceous earth as main raw materials and a method for manufacturing the same.

The present invention provides an interior material for eco-friendly construction comprising white clay and diatomaceous earth.

In a preferred embodiment of the present invention, the white clay may be included in an amount of 40 to 60% by weight based on the total weight.

In a preferred embodiment of the present invention, the diatomaceous earth may be included in an amount of 1 to 20% by weight.

In a preferred embodiment of the present invention, the interior material for eco-friendly construction may additionally include white silica sand and an inorganic binder.

In a preferred embodiment of the present invention, the white silica sand and the inorganic binder may be included in an amount of 10 to 30% by weight and 10 to 30% by weight, respectively, based on the total weight.

In a preferred embodiment of the present invention, the interior material for eco-friendly construction may additionally include a functional natural mineral.

In a preferred embodiment of the present invention, the eco-friendly building interior material may be to reduce any one or more cytokines selected from the group consisting of IL-2, IL-6 and IL-13.

In a preferred embodiment of the present invention, the interior material for eco-friendly construction may relieve at least one itch selected from the group consisting of atopic itch, allergic itch and scalp itch.

In addition, the present i) preparing a mixture by mixing clay and diatomaceous earth;

ii) filtering the size of the materials mixed in the mixture of step i) to 0.1mm to 2mm or less;

iii) molding and coating the filtered mixture of step ii) with a press molding machine; and

iv) naturally drying the coated press-molded product of step iii);

It provides a method for manufacturing an interior material for an eco-friendly building comprising a.

According to a preferred embodiment of the present invention, the clay of step i) may be included in an amount of 40 to 60% by weight based on the total weight.

According to a preferred embodiment of the present invention, the diatomaceous earth in step i) may be included in an amount of 1 to 20 wt% based on the total mixture.

According to a preferred embodiment of the present invention, the drying in step iv) may be drying at 10 to 40 ℃.

According to a preferred embodiment of the present invention, the interior material for eco-friendly construction may relieve at least one itch selected from the group consisting of atopic itch, allergic itch and scalp itch.

The interior material for construction including white clay and diatomaceous earth provided in the present invention contains white clay as a main raw material and has the unique effect of white soil, so it can provide humidity control, non-combustible function, deodorizing effect or antibacterial effect, etc. In fact, the interior material for construction If you live in a building constructed with a cortex, it inhibits the expression level of inflammatory cytokines and has an excellent skin regeneration effect, so it can provide an effect of alleviating itching, especially atopic itch.

1 shows a manufacturing process diagram of the interior material for an eco-friendly building according to the present invention.
2 shows the atopy improvement effect according to the components included in the interior material for eco-friendly construction.
3 shows the skin irritation test results according to the components included in the interior material for eco-friendly construction.
4 shows the results of H&E staining of the skin of the atopic mouse model according to the components included in the interior material for eco-friendly construction.
5 shows the results of measuring the thickness of the epidermis by H&E dyeing the skin of the atopic mouse model according to the components included in the eco-friendly interior material for construction.
6 shows the atopy improvement effect of components that may be included in the interior material for eco-friendly construction.
7 shows skin irritation test results according to components that may be included in interior materials for eco-friendly construction.
8 shows the results of H&E staining of the skin of the atopic mouse model according to the components that may be included in the interior material for eco-friendly construction.
9 shows the results of measuring the thickness of the epidermis by H&E dyeing the skin of the atopic mouse model according to the components that may be included in the interior material for eco-friendly construction (Vehicle: 21.702 μm, Sham: 80.346 μm, clay 10% (Q100): 70.303 μm, diatom 10% (Q10): 32.788 μm, diatom 20% (Q20): 35.953 μm, gypsum: 68.118 μm and concrete: 62.037 μm).
10 shows the levels of itch and inflammatory cytokines in an atopic mouse model according to components that may be included in interior materials for eco-friendly construction.
11 shows the atopy improvement effect of components that may be included in the interior material for eco-friendly construction.
12 shows the atopy improvement effect of components that may be included in the interior material for eco-friendly construction.
13 shows skin irritation test results according to components that may be included in interior materials for eco-friendly construction.

Hereinafter, the present invention will be described in more detail.

As described above, the exact cause of itching (pruritus) has not been identified until now, making it difficult to develop an appropriate therapeutic agent. The antipruritic agents currently used are mainly topical antipruritic agents, not direct antipruritic agents, cannot guarantee safety when used for a long period of time, and have various side effects such as skin discoloration and reduced immunity. A problem exists.

Accordingly, the present inventors have made an effort to provide an environmental composition capable of improving harmful environmental factors that directly affect the human body, and as a result, have completed an eco-friendly interior material for construction including white clay and diatomaceous earth. It was confirmed that the interior material for eco-friendly construction according to the present invention exhibits a strong itch suppression and alleviation effect as a result of an itch-induced animal behavior model test and tissue microscopic findings. The itch-inducing animal model is a mouse model in which itch is induced with histamine or DNCB, and reflects itch caused by various causes, including atopic itch. Therefore, the eco-friendly building interior material of the present invention can provide an effect of suppressing or alleviating itching caused by various causes, such as atopic itch, scalp itch, and allergy itch.

The 'environmental composition' of the present invention refers to a composition that can be used for living environment composition, and preferably may refer to an interior material composition for construction.

Accordingly, the present invention can provide an eco-friendly interior material for construction including white clay and diatomaceous earth.

The white soil is collected from the underground of a clean mountain mine in an unpolluted area and has been removed from impurities. It is made of porous fine particles and has excellent humidity control function, as well as non-detection of four heavy metals (lead, mercury, cadmium, arsenic) and blocking harmful compounds (VOCs). , formaldehyde adsorption decomposition, nonflammability, heat insulation, sound insulation, antibacterial, antifungal, far-infrared rays or anions (promoting blood circulation, activating metabolism) or deodorizing effects, etc.

The diatomaceous earth is a kind of natural mineral of sedimentary rocks made by depositing diatoms, a type of phytoplankton, and is composed of porous fine particles. It has excellent humidity control, antifungal, deodorizing effect, or reduction of formaldehyde, which is the cause of sick house syndrome. In particular, in Japan, it has been certified as a building material that reduces pollution caused by volatile organic compounds (VOCs) in indoor air.

According to a preferred embodiment of the present invention, the white clay may be included in an amount of 40 to 60% by weight based on the total weight. Preferably, the white clay may be included in an amount of 45 to 55 wt% based on the total weight, and more preferably, the white clay may be included in an amount of 47 to 52 wt% based on the total weight.

The diatomaceous earth may be included in an amount of 5 to 20% by weight based on the total weight. Preferably, the diatomaceous earth may be included in an amount of 7 to 15% by weight, and more preferably, the diatomaceous earth may be included in an amount of 9 to 12% by weight. When diatomaceous earth is included in less than 5% by weight, the efficacy of diatomaceous earth, such as improvement of atopy, may not appear, and when included in excess of 20% by weight, durability of the product such as brittleness may be reduced due to its porous characteristics.

According to a preferred embodiment of the present invention, the interior material for eco-friendly construction may additionally include white silica sand and an inorganic binder.

The white silica sand is domestic natural white sand, and may be included to reinforce the strength of the interior material for eco-friendly construction, and the white silica sand may be included in an amount of 10 to 30 wt%, preferably 15 to 25 wt%, based on the total weight. More preferably, it may be included in an amount of 18 to 22 wt%.

The inorganic binder is a biodegradable, non-toxic, eco-friendly binder (adhesive) that is mixed with white soil to reinforce the bonding strength and strength of the board, and may be included in an amount of 10 to 30% by weight, preferably 15 to 25% by weight, based on the total weight. %, and more preferably 18 to 22% by weight. The inorganic binder may be an eco-friendly inorganic binder without harmful components such as non-detection of radon or heavy metals as an inorganic curing agent such as calcium carbonate, which is a natural mineral.

The eco-friendly building interior material may additionally include water. The water may be included in an amount of 1 to 10% by weight, preferably 5 to 9% by weight, based on the total weight.

According to a preferred embodiment of the present invention, the eco-friendly building interior material may additionally include a functional natural mineral. The functional natural mineral may be zeolite, iolite, pearlite or eco-healing stone.

The zeolite is a material made by hardening lava when a volcano erupts. It has an adsorption/decomposition effect of toxin substances such as heavy metals, an excellent water purification effect with a large amount of natural minerals, and a catalyst, ion exchanger, and various adsorbents with antibacterial/anti-fungal inhibitory effect. is utilized

The iolite is an eco-friendly natural mineral produced in Korea that emits a large amount of #free electrons (e-) to promote metabolism and remove odors. It is a mineral that has deodorizing and antibacterial effects. is a mineral

The perlite is a rock made by heating and expanding perlite at a high temperature, and has a lot of fine pores due to alkali sterility and non-toxicity, so it is light and has excellent humidity control effect.

According to a preferred embodiment of the present invention, the eco-friendly building interior material may be to reduce any one or more cytokines selected from the group consisting of IL-2, IL-6 and IL-13.

According to a preferred embodiment of the present invention, the interior material for eco-friendly construction may relieve at least one itch selected from the group consisting of atopic itch, allergic itch and scalp itch. More preferably, the interior material for eco-friendly construction may be to relieve atopic itch.

According to a preferred embodiment of the present invention, the building interior material may be a panel or a board, but is not limited thereto.

The process of manufacturing an eco-friendly building interior material containing white clay and diatomaceous earth of the present invention is largely divided into material (white earth, diatomaceous earth, white silica sand or inorganic binder) supply and demand, material mixing (white earth, diatomaceous earth, white silica sand, inorganic binder or water), and mixed materials Transfer, material filtering, feed meter transfer, material granulator crushing, material mixer transfer return, feed meter transfer/press input, press compression production, product conveyor transfer, product surface coating spray (1 time), stacking on drying rack, dry wheat car It can consist of the steps of piling up, natural drying, product inspection, product packaging, and product shipping. When manufacturing interior materials for construction by the press method as described above, compared to other methods such as the extrusion method, it is cost-effective and the proportion of defective products can be effectively reduced.

Specifically, in the material filtering and feeding metering step, the material was fed to the screen sorter using a conveying conveyor in the material mixer, and then the materials were filtered by the size standard by the screen sorter, and then transferred to the feed metering machine and put into the press waiting for input. Materials larger than the reference size were returned to the material mixer after grinding.

In the product packaging and product shipping step, the products that passed the quality inspection were classified by standard, packaged and then transported to the storage warehouse, and the product was shipped after the shipment inspection according to the product shipping instructions.

Accordingly, the present invention comprises the steps of i) preparing a mixture by mixing clay and diatomaceous earth;

ii) filtering the size of the materials mixed in the mixture of step i) to 0.1mm to 2mm or less;

iii) molding the filtered mixture of step ii) into a product by a press molding machine; and

iv) naturally drying the press-formed product of step iii);

It is possible to provide a method for manufacturing an interior material for an eco-friendly building comprising a.

The size of the mixed materials filtered in step ii) may be preferably 0.5 mm to 1.5 mm or less, and more preferably 1 mm or less.

In step iii), the press molding machine may mold the product at a pressure of 100 bar to 400 bar, preferably at a pressure of 150 bar to 300 bar, more preferably 190 bar to 250 bar The product can be molded under the pressure of

After the product molding of step iii), the method may further include coating the molded product with an eco-friendly water-soluble coating agent to thinly coat the product surface once.

According to a preferred embodiment of the present invention, the natural drying in step iv) may be drying at room temperature of 10 to 40°C, preferably drying at 15 to 35°C. Artificially applying heat above room temperature may cause deformation of the product to be dried. In addition, the natural drying may be carried out for 1 to 5 days, preferably for 2 to 4 days.

Since the concepts used in the manufacturing method are the same as those included in the eco-friendly building interior material, the description is replaced with the above description.

According to a preferred embodiment of the present invention, the interior material for eco-friendly construction may relieve at least one itch selected from the group consisting of atopic itch, allergic itch and scalp itch. More preferably, the interior material for eco-friendly construction may be to relieve atopic itch.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention, and it is obvious to those of ordinary skill in the art that the scope of the present invention is not to be interpreted as being limited by these examples.

Manufacture of interior materials and mouse models for eco-friendly construction

<1-1> Manufacturing of interior materials for eco-friendly construction

An attempt was made to select a raw material that can be included in the preparation of an environmental composition having an itch improvement effect caused by various causes such as atopic itch. Among the environmental compositions, a board (panel) for an eco-friendly building interior material was prepared with the composition shown in [Table 1] below, including white clay, white clay (white clay + diatomaceous earth), white clay + chilbo or ocher.

ingredient clay board Baekkyu board
(white earth + diatomaceous earth) White clay + Cloisonne board ocher board clay 6.11 kg 6.11 kg 6.11 kg diatomaceous earth 0.68 kg cloisonne 0.68 kg ocher 6.79 kg

Specifically, powdered white clay (0.1mm~1mm), minerals (powdered diatomaceous earth, cloisonn or loess; 1mm or less) and natural mineral inorganic binder (hardener) are put in a mixer and mixed for about 40~60 minutes, and then water ( 6% to 8% by weight of the mixture) was added and mixed for 40 to 60 minutes.

1mm or less (about 90%~95%) is transferred directly to the feed meter through the screen sorter, and particles larger than 1mm (5%~10%) are pulverized with a grinder and returned to the material mixer. The mixed materials (1 mm or less) were transferred to a feed meter and put into a mold of a press molding machine to form products with a product size and press pressure of about 200 bar to 240 bar. After that, the surface of the product was thinly coated once with an eco-friendly water-soluble coating agent through the coating line during automatic transfer of the press-molded product. After forming the coated press product, it was placed on a drying rack and a dry mill, moved to a natural drying room, and dried naturally at room temperature (15°C to 35°C) for 3 days. Quality inspection (standard, flatness, surface condition, etc.) of completely dried products The dimensions of the manufactured board were 600mm×300mm/9.0mm~9.5mm (3kg) or 300mm×300mm/8.5mm~9mm (1.5Kg).

<1-2> Manufacture and acceptance of atopic mouse model

Male ICR mice weighing 20-23 g were used, and DNCB (1-Chloro-2,4-dinitrobenzene), which causes contact hypersensitivity by triggering an immune response, was used as the chemical used for skin sensitization in the atopic model. Specifically, 1.5% DNCB (200 μl in acetone: olive oil = 4:1) was treated on the first day after being accommodated in the eco-friendly building interior material prepared in Example <1-1>, and 1% DNCB on the second day was treated. While food and water were freely edible, each was accommodated in the eco-friendly building interior material prepared in Example <1-1>, and then observed with a recovery period of one week.

Effects of eco-friendly building interior materials on skin appearance

The appearance of the skin recovery patterns of the mice received in Example <1-2> was observed.

Vehicle means a normal mouse model, and Sham means a mouse model housed in a general cage rather than an eco-friendly interior material after DNCB treatment.

As a result, as shown in [Fig. 2], it was confirmed that the atopy improvement effect of the eco-friendly building interior material including white clay and diatomaceous earth was the best among various eco-friendly interior materials.

Anti-itch effect of eco-friendly interior materials for construction

The effect of the mice housed in Example <1-2> on atopy-related itch by the environment of clay and diatomaceous earth was checked. After recovering the created atopic model in various environments, a skin irritation test (itch that occurs after light touch stimulation with a brush) was performed, and the number of voluntary scratching (Scratch bouts) was observed for 30 minutes.

As a result, as shown in [Fig. 3], the number of scratching for 30 minutes was less than 5 times in the normal mouse model (Vehicle, control), and about 20 times in the atopic animal model (Sham, positive control). On the other hand, in the case of receiving in loess, the number of scratching was increased more than twice as compared to the positive control. The number of scratching when accommodated in the interior material for eco-friendly construction containing white clay and diatomaceous earth of the present invention was 5 to 6 times similar to that of the normal control group.

Effects of eco-friendly building interior materials on skin tissue

It was attempted to confirm the skin histological changes of the mice received in Example <1-2>.

As a result, as shown in [FIG. 4] and [FIG. 5], the skin of the positive control (sham, atopic model) had an epidermis thickened compared to the control (vehicle), and the thickness thereof was greatly increased. This means that changes in the atopic model were induced not only in appearance but also histologically, and it was judged to be suitable for the criteria for atopy. In addition, compared to the mouse model accommodated in white clay, white clay and cloisonne or loess, in the case of the mouse model (diatom) accommodated in white clay and diatomaceous earth eco-friendly interior materials, it was confirmed that the thickness of the epidermal layer was the most similar to that of the normal control group.

Establishment of specific composition ratio of interior materials for eco-friendly construction

<5-1> Manufacturing of interior materials for eco-friendly construction

Based on the results of [Example 1] to [Example 4], it was determined that the itch improvement effect was significant when both white clay and diatomaceous earth were included. In addition, it was attempted to determine the specific composition ratio of white clay and diatomaceous earth.

In the same manner as in Example <1-1>, a building board containing 100% white clay (Q100), 10% diatom (Q10), 20% diatom (Q20), gypsum or concrete was cut by 600 mm × The size of 600 mm × 10 mm (7 kg) was prepared in the configuration of [Table 2] below.

ingredient clay board Diatom 10 board Diatom 20 board Gypsum board concrete board clay 6.11 kg 6.11 kg 5.43kg diatomaceous earth 0.68 kg 1.36kg gypsum 1.90kg gypsum hardener 0.10 kg cement 2.92kg sand 4.38kg

<5-2> Effects of eco-friendly building interior materials on skin appearance

In the same manner as in <Example 4>, it was attempted to confirm the skin recovery effect on the atopic mouse model of the interior material for eco-friendly construction prepared in Example <5-1>.

As a result, as shown in [Fig. 6], mice accommodated in a plaster environment did not show any improvement in atopy, and mice accommodated in a clay or concrete environment showed some improvement in atopy. On the other hand, it was confirmed that a significant improvement in atopy was observed in the interior materials for eco-friendly construction containing 10% or 20% of diatomaceous earth, and in particular, in the case of the interior materials for eco-friendly construction with 10% diatomaceous earth (diatomite 10), atopy was recovered to a level similar to that of the normal control group. could This means that for the atopic model, eco-friendly interior materials for construction including white clay and diatomaceous earth have anti-itching effect and rapid skin regeneration effect.

<5-3> Effects of eco-friendly building interior materials on histamine-induced itchiness

It was attempted to confirm the itch improvement effect on the atopic mouse models of the interior material for eco-friendly construction prepared in Example <5-1>.

Specifically, male ICR mice weighing 20 to 23 g were each accommodated in the eco-friendly building interior material prepared in Example <1-2> under the temperature control of 23 to 25 ° C while allowing food and water to be freely eaten. One day before the experiment, the experimental animals were anesthetized by mixing zoletil and rompun in a ratio of 1:4 and administering 1 ㎖/kg. The hairs were removed with a square of cm. 100 µl of the solvent or test substance is applied to the back of the mouse's neck, and after 30 minutes, 50 µl of histamine (500 µg/site: 10 µg/site) dissolved in sterile physiological saline is intradermally injected behind the neck. After that, the movement of the mouse was observed for 30 minutes, and the number of voluntary scratching of the injection site with the hind leg (Scratch bouts) was observed. The data were analyzed by calculating the mean and standard deviation, and the statistical difference between the mean values was determined using Student's t-test.

As a result, as shown in [Fig. 7], when accommodated in an eco-friendly building interior material containing both white clay and diatomaceous earth, the number of times the mouse scratched was less than 10 times, which was the number of times most similar to that of the control group. In particular, on the 6th day after accommodation, mice housed in an environment (Q10) containing 10% of diatomaceous earth in white diatomaceous earth scratched significantly less than mice housed in an environment (Q20) containing 20% of diatomaceous earth. On the other hand, it was confirmed that the number of times of scratching for 30 minutes was about 50 times when accommodated in an eco-friendly building interior material containing white clay, gypsum, or concrete that did not contain diatomaceous earth. On the other hand, the formulations used in the experiment showed good formulation stability and no side effects on the skin.

<5-4> Confirmation of skin tissue change

It was attempted to confirm the effect on the skin tissue of the atopic mouse models when accommodated in the eco-friendly interior material for construction prepared in Example <5-1> in the same manner as in [Example 4].

As a result, as shown in [Fig. 8] and [Fig. 9], the thickness of the epidermal layer was similar to that of the positive control (Sham) in the case of the mouse model accommodated in the white clay (Q100), gypsum (Gypsum) or concrete environment. it was On the other hand, it was confirmed that the epidermis was thinned to a thickness of about 40% of that of the positive control when accommodated in the eco-friendly interior material containing diatomaceous earth. It was found that the epidermis of the atopic mouse model was thinner than that of the atopic mouse model.

<5-5> Inflammation-related cytokine level confirmation

In the atopic mouse models accommodated in the interior material for eco-friendly construction prepared in Example <5-1>, it was attempted to confirm the level change of IL-2, IL-6, or IL-13, which are cytokines related to inflammation.

As a result, as shown in [Fig. 10], in the case of the mouse model accommodated in a gypsum or concrete environment, the level of cytokines was rather increased than that of the positive control (Sham). On the other hand, when white clay was included, the level of cytokines was decreased, and it was confirmed that the level of inflammatory cytokines was reduced more significantly compared to the case where diatomaceous earth was included 10% (Q10) and 20% (Q20). there was.

Effects of eco-friendly interior materials for building interiors on acute mechanical pain response or movement response

White clay and diatomaceous earth are used as environmental agents and can affect other sensory nerve cells or motor nerves. Therefore, the rotarod motor ability to evaluate the pain response and motor nerve effect, which is one of the sensory information, was evaluated at the concentration effective for itch.

As a result, mechanical pain using von-Frey did not show a significant difference between the green interior materials containing white clay and diatomaceous earth and the control group. In addition, no abnormalities in motor behavior were observed at any of the concentrations used in the experiment. Therefore, the inclusion of white clay and diatomaceous earth was not related to the effect on sensory nerves, and it was judged that the itch blocking effect was not caused by disorders such as movement.

Manufacture of interior materials for eco-friendly construction including white clay and diatomaceous earth

<7-1> Manufacturing of interior materials for eco-friendly construction

Based on the results of [Example 1] to [Example 6], it was determined that the itch improvement effect was significant in the case of the eco-friendly building interior material containing both white clay and diatomaceous earth. Additionally, it was attempted to check whether the functionality of eco-friendly building interior materials was enhanced by adding functional natural minerals other than diatomaceous earth to white clay.

Specifically, white silica sand (0.1 mm to 1 mm) and functional natural minerals zeolite, iolite, pearlite, or eco-healing stone were additionally added, and in the same manner as in Example <1-1>, an eco-friendly building interior material was prepared. Functional natural minerals were added together when mixing materials such as white clay and diatomaceous earth, and the specific composition is as described in [Table 3] below.

ingredient Cage#1
(weight ratio) Cage#2 Cage#3 Cage#4 Cage#5 Cage#6 clay 1.5 kg (50%) 1.5 kg 1.5 kg 1.5 kg 1.5 kg 1.5 kg diatomaceous earth 0.3 kg (10%) 0.24 kg zeolite 0.3 kg iolite 0.3 kg 0.06 kg perlite 0.3 kg Eco Healing Stone 0.3 kg Baekkyusa 0.6 kg (20%) 0.6 kg 0.6 kg 0.6 kg 0.6 kg 0.6 kg weapon binder 0.6 kg (20%) 0.6 kg 0.6 kg 0.6 kg 0.6 kg 0.6 kg

<7-2> Atopy improvement effect

In the same manner as in Example <1-1>, it was attempted to confirm the skin recovery effect on the atopic mouse model of the eco-friendly building interior material prepared in Example <7-1>.

As a result, as shown in [Fig. 11] and [Fig. 12], it was confirmed that a significant improvement in atopy was exhibited when functional natural minerals were additionally included in the clay. Vehicle means a mouse housed in a general cage after administering only acetone and olive oil, and Sham means a mouse housed in a general cage after administering acetone, olive oil and DNCB.

<7-3> Itching improvement effect

It was intended to confirm the itch improvement effect on the atopic mouse models of the eco-friendly interior material for construction prepared in Example <7-1>.

Specifically, male ICR mice weighing 20 to 23 g were each accommodated in the eco-friendly building interior material prepared in Example <1-2> under the temperature control of 23 to 25 ° C while allowing food and water to be freely eaten. One day before the experiment, the experimental animals were anesthetized by mixing zoletil and rompun in a ratio of 1:4 and administering 1 ㎖/kg. The hairs were removed with a square of cm. 100 µl of the solvent or test substance is applied to the back of the mouse's neck, and after 30 minutes, 50 µl of histamine (500 µg/site: 10 µg/site) dissolved in sterile physiological saline is intradermally injected behind the neck. After that, the movement of the mouse was observed for 30 minutes, and the number of voluntary scratching of the injection site with the hind leg (Scratch bouts) was observed. The data were analyzed by calculating the mean and standard deviation, and the statistical difference between the mean values was determined using Student's t-test.

As a result, as shown in [Fig. 13], it could be confirmed that the number of scratches of the mouse was significantly reduced when the functional natural mineral was additionally included in the clay. In particular, it was found that the itch improvement effect was most significantly increased in the interior materials for eco-friendly construction including white clay and diatomaceous earth. On the other hand, the formulations used in the experiment showed good formulation stability and no side effects on the skin.

Claims (14)

As an interior material for eco-friendly construction comprising white clay, diatomaceous earth, white silica sand, and inorganic binder in an amount of 47 to 52% by weight, 9 to 12% by weight, 18 to 22% by weight, and 18 to 22% by weight, respectively, based on the total weight,
The eco-friendly building interior material is characterized in that it additionally contains iolite as a functional natural mineral,
The interior material for eco-friendly construction, characterized in that it relieves any one or more itch selected from the group consisting of atopic itch, allergic itch and scalp itch.
delete delete delete delete delete [Claim 2] The interior material for eco-friendly construction according to claim 1, wherein the interior material for eco-friendly construction reduces any one or more cytokines selected from the group consisting of IL-2, IL-6 and IL-13.
delete i) preparing a mixture by mixing white clay, diatomaceous earth, white silica sand, and an inorganic binder in an amount of 47 to 52% by weight, 9 to 12% by weight, 18 to 22% by weight, and 18 to 22% by weight, respectively, based on the total weight;
ii) filtering the size of the materials mixed in the mixture of step i) to 0.1mm to 2mm or less;
iii) coating the molded product after molding the filtered mixture of step ii) with a press molding machine; and
iv) naturally drying the press-formed product of step iii) at 10 to 40°C;
As a method for manufacturing an interior material for eco-friendly construction comprising a,
The eco-friendly building interior material is characterized in that it additionally contains iolite as a functional natural mineral,
The eco-friendly building interior material manufacturing method, characterized in that alleviating any one or more itch selected from the group consisting of atopic itch, allergic itch and scalp itch.


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