KR102357626B1 - Chiral nanostructure - Google Patents

Abstract

The present invention is a nanostructure having utility in various technical fields through structural chirality and real-time self-assembly, and specifically, it includes two or more nanoparticle array structures, wherein the nanoparticle array structure comprises at least one nanoparticle array structure. a first structure including particles; and a second structure including at least one nanoparticle and spaced apart from the first structure, wherein the nanoparticles include magnetic plasmonic particles, and the entire structure has chiarality. The bands provide chiral nanostructures.

Description

Chiral nanostructure {CHIRAL NANOSTRUCTURE}

It relates to a nanostructure having chirality, and it relates to a nanostructure that can implement and modulate precise and immediate chirality and can be widely applied in various technical fields.

With the continuous development of synthesis technology, it has become possible to use metals to manufacture nanoparticles having a size of a nano level, and it has been found that these nanoparticles have various and unique properties due to the advancement of analysis technology. For example, in the case of nano-sized metallic particles, it was found that the optical properties of the three-dimensional structure made of them change depending on the geometric structure, which is due to the localized surface plasmon resonance (LSPR) phenomenon. lost. These nanoparticles can be utilized in various technical fields, such as optics, biotechnology, and catalysts, as a 3D structure by itself or in accordance with its composition and structure. In addition, as the field of nanoscience has recently been spotlighted as a new next-generation industrial field, the demand for nanoparticles of various compositions and structures is increasing. In accordance with this technological trend, research on synthesizing a three-dimensional structure using nanoparticles of a specific composition and structure is being actively conducted, mainly using a chemical synthesis method. For example, recently, a method for synthesizing using a peptide to which two or more amino acids are bound has been proposed. In addition, a method using e-beam lithography, a hole lithography method using nano-sized holes to perform rotational deposition, and the like are being studied.

On the other hand, all substances that exist in nature have chirality. For example, in the case of amino acids, most consist of L-amino acids, and in the case of saccharides, D-sugars are the mainstay. As such, living organisms always have homo-chirality, so when they react with a filtering material, fatal damage to the organism appears. A chiral structure prepared from nanoparticles by applying such chirality refers to a three-dimensional structure having an asymmetric structure that does not have any mirror image symmetry. In the chiral structure, the degeneracy of right and left polarization is broken because electric dipoles and magnetic dipoles generated by incident electromagnetic waves interact in the same direction. Accordingly, the chiral structure has different refractive indices with respect to the left polarized light and the right polarized light. Accordingly, when linearly polarized light is incident on the chiral material, a photoactive characteristic in which the polarization state is rotated appears. The chiral structure can be variously used in optical materials and catalyst fields by using such photoactive properties.

As described above, a three-dimensional chiral structure composed of a geometrically aligned structure of nanoparticles is often prepared by a chemical synthesis method. However, the conventional synthesis of nanoparticles and structures using the same is complex and lacks precision and accuracy. Accordingly, the present inventors have researched a method for producing a chiral nanostructure in a more sophisticated manner with a simpler process, and have completed the present invention.

KR 10-2019-0117370 A KR 10-1581406 B1

One embodiment of the present invention is to provide a chiral nanostructure having structural chirality and real-time self-assembly. In addition, it is an object to provide a chiral nanostructure having wide applicability in various technical fields such as optics, bio, and catalyst fields by including nanoparticles that are capable of plasmon resonance and that can be arranged in a predetermined arrangement in a magnetic field in one configuration.

In one embodiment of the present invention, the first structure comprising two or more nanoparticle array structures, wherein the nanoparticle array structure includes at least one nanoparticle; and a second structure including at least one nanoparticle and spaced apart from the first structure, wherein the nanoparticles include magnetic plasmonic particles, and the entire structure has chiarality. , to provide a chiral nanostructure.

The chirality of the chiral nanostructure may have a variable characteristic by applying a helical magnetic field.

In the chiral nanostructure, the time (T2-T1) from the application time point (T1) of the helical magnetic field to the time point (T2) at which the change is completed to exhibit chirality corresponding to the applied helical magnetic field is 0.01 ms to It may be 20 ms.

A distance between the first structure and the second structure may be in a range of 0.01 nm to 50 µm.

The chiral nanostructure has structural chirality and real-time self-assembly. The structural chirality can be imparted through a significantly simpler means compared to the conventional means, and additional modulation has an immediate advantage.

In addition, the chiral nanostructure can exhibit a wide range of applications in various technical fields such as optical fields by including nanoparticles capable of plasmon resonance and arranged in a predetermined arrangement in a magnetic field as one configuration.

1 is a perspective view schematically illustrating a part of the chiral nanostructure according to an embodiment.
2 schematically illustrates a cross-section of the nanoparticles of the chiral nanostructure according to some embodiments.
3 is a photograph showing nanoparticles according to an embodiment.
4 is a photograph showing nanoparticles according to another embodiment.
5 is a schematic diagram schematically illustrating a method for manufacturing the chiral nanostructure according to an embodiment.
6 schematically illustrates a magnetic body rotation state in the process of manufacturing the chiral nanostructure according to an embodiment.
7 schematically illustrates a particle arrangement step of the process of manufacturing the chiral nanostructure according to an embodiment.
FIG. 8 shows a circular dichroism spectroscopy (CD) spectrum for each concentration and rotation angle for the chiral nanostructure of Example 1. FIG.
FIG. 9 shows a circular dichroism spectroscopy (CD) spectrum for each concentration and rotation angle of the chiral nanostructure of Example 2. FIG.
FIG. 10 shows a Circular Dichroism Spectroscopy (CD) spectrum for each concentration and rotation angle of the chiral nanostructure of Example 3. FIG.
FIG. 11 shows a circular dichroism spectroscopy (CD) spectrum for each concentration and rotation angle of the chiral nanostructure of Example 4. FIG.

Advantages and features of the present invention, and a method of achieving them will become clear with reference to the following examples. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in various different forms, Only the present embodiments are provided to complete the disclosure of the present invention, and to fully inform those of ordinary skill in the art to which the present invention belongs, the scope of the invention, the present invention is defined by the scope of the claims will only be

In the drawings of the present specification, the thickness is enlarged in order to clearly express various layers and regions. And in the drawings, for convenience of description, the thickness of some layers and regions are exaggerated. Like reference numerals refer to like elements throughout.

In this specification, the meaning of 'more than' is interpreted to include the corresponding number or more cases. For example, 'two or more' means two or more cases. In addition, the description of 'X to Y' for a numerical range is interpreted as a range including X or Y. For example, '25 to 50' means a numerical range inclusive of 25 and 50.

In one embodiment according to the present invention, it includes: a first structure comprising two or more nanoparticle array structures, wherein the nanoparticle array structure includes at least one nanoparticle; and a second structure including at least one nanoparticle and spaced apart from the first structure, wherein the entire structure provides a chiral nanostructure having chiarality.

Chirality refers to the asymmetric property. Particulate structures having structural chirality may be usefully applied to optical technology fields such as liquid crystal displays (LCDs) or bio fields such as pharmaceuticals. The chiral nanostructure can implement a high level of chiral modulation performance through simple structural processing and deformation. The chiral modulation performance can realize very high performance in the field of nano science requiring an immediate and fast reaction speed.

In one embodiment, the chirality of the nanostructure may exhibit a variable property by applying a helical magnetic field. The chirality of the nanostructure is derived from the overall structural characteristics of the nanostructure. In the nanostructure, the structural characteristics can be immediately and quickly transformed by a relatively simple means of applying a helical magnetic field, and as a result, variability in which the chirality of the nanostructure is changed immediately and quickly can be secured.

For example, the nanostructure is a time (T2-) from the application time point (T1) of the helical magnetic field to the time point (T2) at which the structural change is completed to exhibit chirality corresponding to the chirality of the applied helical magnetic field. T1) may be about 0.01 ms to about 20 ms, for example, about 0.01 ms to about 10 ms. This exhibits a significantly faster reaction rate than the conventional chiral modulation function using a template, etc., and can be applied to various industrial fields such as medicine and optics to realize excellent functions.

1 is a perspective view schematically illustrating a part of the chiral nanostructure according to an embodiment. Referring to FIG. 1 , the chiral nanostructure 200 includes two or more nanoparticle array structures 210 in a three-dimensional space. The nanoparticle array structure 210 includes at least one nanoparticle 22 , and the nanoparticle 22 has a predetermined arrangement.

The nanoparticle array structure 210 may include a first structure 201 including at least one nanoparticle 22; and a second structure 202 including at least one nanoparticle 22 and spaced apart from the first structure 201 . The first structure 201 and the second structure 202 refer to any two adjacent structures among the two or more nanoparticle array structures 210 . The components and structures of the nanoparticles 22 included in the first structure 201 and the nanoparticles 22 included in the second structure 202 may be the same or different.

In one embodiment, the spaced straight distance between the first structure 201 and the second structure 202 may be about 0.01 nm to about 50 μm. By adjusting the separation distance between any two structures in the above range, the variable speed of chirality of the nanoparticle array structure can be quickly implemented to a desired level, and it can be applied to optical or bio fields to realize an optimal function.

The nanoparticles 22 may include magnetic plasmonic particles. Plasmon refers to a phenomenon in which free electrons inside a metal vibrate collectively. In the case of metal nanoparticles, plasmons may exist locally on the surface, which may be referred to as surface plasmons. When the metal nanoparticles meet the electric field of light in the range from visible light to near-infrared light, light absorption occurs by surface plasmon resonance (SPR) to give a vivid color. The magnetic plasmon particles are plasmonic particles having magnetism, and may be arranged in a predetermined arrangement in a magnetic field by magnetism, and may be colored by a plasmon phenomenon.

Specifically, the magnetic plasmon particles may include a core; and a core-shell particle surrounding at least a portion of the surface of the core and having a shell including a component different from that of the core. That the shell includes a component different from the component of the core should be interpreted as including a case in which all components are different from each other, as well as a case in which the overall composition is different even if some of the same components are included.

For example, in the core-shell particle, one of the core and the shell may include a magnetic component, and the other may include a metal component. a core including a magnetic component and a shell including a metal component; Alternatively, through a combination of a shell including a magnetic component and a core including a metal component, it may be advantageous for the nanostructures to be aligned in a predetermined arrangement in a magnetic field while realizing a desired color to form a precise chiral structure.

The metal component is, for example, silver (Ag), gold (Au), platinum (Pt), copper (Cu), palladium (Pd), iridium (iridium), osmium (osmium), rhodium (rhodium), ruthenium (ruthenium), nickel (Ni), cobalt (Co), iron (Fe), manganese (Mn), chromium (Cr), vanadium (V), titanium (Ti), aluminum (Al), zinc (Zn), cadmium It may include one selected from the group consisting of (Cd) and combinations thereof.

The magnetic component is, for example, iron oxide (Fe ₃ O ₄ ), nickel oxide (NiO), cobalt oxide (Co ₃ O ₄ ), iron (Fe), nickel (Ni), cobalt (Co), and combinations thereof It may include one selected from the group consisting of.

In one embodiment, the core is silver (Ag), gold (Au), platinum (Pt), copper (Cu), palladium (Pd), iridium (iridium), osmium (osmium), rhodium (rhodium) , ruthenium, nickel (Ni), cobalt (Co), iron (Fe), manganese (Mn), chromium (Cr), vanadium (V), titanium (Ti), aluminum (Al), zinc (Zn) , including one selected from the group consisting of cadmium (Cd) and combinations thereof, and the shell is iron oxide (Fe ₃ O ₄ ), nickel oxide (NiO), cobalt oxide (Co ₃ O ₄ ), iron ( Fe), nickel (Ni), cobalt (Co), and may include one selected from the group consisting of combinations thereof.

In another embodiment, the core is iron oxide (Fe ₃ O ₄ ), nickel oxide (NiO), cobalt oxide (Co ₃ O ₄ ), iron (Fe), nickel (Ni), cobalt (Co) and these including one selected from the group consisting of a combination of silver (Ag), gold (Au), platinum (Pt), copper (Cu), palladium (Pd), iridium (iridium), osmium), rhodium, ruthenium, nickel (Ni), cobalt (Co), iron (Fe), manganese (Mn), chromium (Cr), vanadium (V), titanium (Ti), aluminum ( Al), zinc (Zn), cadmium (Cd), and may include one selected from the group consisting of combinations thereof.

Through such a core-shell structure, the nanostructure can realize excellent color expression and optical properties, and there is an advantage that it is easy to control the nanoparticles to be aligned in a desired arrangement in a magnetic field, and for fine control of the magnetic field The arrangement can be changed in real time, which can be advantageous for chirality control.

2 schematically illustrates a cross-section of the magnetic plasmon particle in accordance with some embodiments. Referring to FIG. 2 , the magnetic plasmon particle may be a core-shell particle including a core 14 and a shell 15 surrounding at least a portion of the core, as described above. Referring to FIGS. 2A and 2B , the core-shell particles may be spherical core-shell particles. Specifically, the spherical core-shell particle may have a structure including the core 14 and the shell 15 surrounding substantially the entire surface thereof, as shown in FIG. As shown in (b), it may have a half-shell structure including the core 14 and the shell 15 surrounding a part of the surface thereof.

In the present specification, the term 'spherical' should be interpreted to include not only a case in which a cross section thereof is geometrically perfect, but also a range that can be recognized as a shape of a sphere in the overall three-dimensional structure within a predetermined error range even if it is elliptical. something to do.

In the present specification, the meaning of 'half-shell' does not mean only when the shell 15 surrounds exactly half of the surface area of the core 14, but rather surrounds at least a part rather than the whole. All are understood to be generic.

Referring to FIG. 2C , the core-shell particles may be rod-shaped core-shell particles. The rod-shaped core-shell particle may also have a structure including the core 14 and a shell 15 surrounding substantially the entire surface thereof, as in the case of the spherical core-shell particle, and the core 14 ) may be a structure (not shown) including a shell 15 surrounding a portion of the surface.

As used herein, the term 'rod-shaped' refers to a shape in which the length and width form a predetermined aspect ratio with respect to its cross section, and it can be understood to encompass all three-dimensional shapes in which the ratio of the length to the width exceeds 2.00. have.

In one embodiment, the core-shell particle comprises a spherical core-shell particle or a rod-shaped core-shell particle, and the spherical core-shell particle or the rod-shaped core-shell particle comprises a core ; and a shell surrounding the entire surface of the core and including a component different from the component of the core, wherein the core includes silver (Ag), gold (Au), platinum (Pt), copper (Cu), palladium ( Pd), iridium, osmium, rhodium, ruthenium, nickel (Ni), cobalt (Co), iron (Fe), manganese (Mn), chromium (Cr), vanadium ( V), including one selected from the group consisting of titanium (Ti), aluminum (Al), zinc (Zn), cadmium (Cd), and combinations thereof, wherein the shell is iron oxide (Fe ₃ O ₄ ), It may include one selected from the group consisting of nickel oxide (NiO), cobalt oxide (Co ₃ O ₄ ), iron (Fe), nickel (Ni), cobalt (Co), and combinations thereof.

For example, the core may include silver (Ag), gold (Au), or a combination thereof, and the shell may include iron oxide (Fe ₃ O ₄ ). Since the nanoparticles have a core-shell structure including a combination of these components, the desired chirality can be precisely given by controlling the magnetic field, and the chirality can be adjusted immediately by the change of the magnetic field. The effect can be maximized.

In another embodiment, the core-shell particle comprises a spherical core-shell particle or a rod-shaped core-shell particle, and the spherical core-shell particle or the rod-shaped core-shell particle comprises a core and a half-shell surrounding a portion of the surface of the core and including a component different from the component of the core, wherein the core includes iron oxide (Fe ₃ O ₄ ), nickel oxide (NiO) ), cobalt oxide (Co ₃ O ₄ ), iron (Fe), nickel (Ni), cobalt (Co) and one selected from the group consisting of combinations thereof, wherein the shell is silver (Ag), Gold (Au), platinum (Pt), copper (Cu), palladium (Pd), iridium, osmium, rhodium, ruthenium, nickel (Ni), cobalt (Co), One selected from the group consisting of iron (Fe), manganese (Mn), chromium (Cr), vanadium (V), titanium (Ti), aluminum (Al), zinc (Zn), cadmium (Cd), and combinations thereof may include

For example, the core may include iron oxide (Fe ₃ O ₄ ), and the shell may include silver (Ag), gold (Au), or a combination thereof. Since the nanoparticles have a core-shell structure including a combination of these components, the desired chirality can be precisely given by controlling the magnetic field, and the chirality can be adjusted immediately by the change of the magnetic field. The effect can be maximized.

3 is a photograph of the spherical core-shell particle according to an embodiment, and FIG. 4 is a photograph of the rod-shaped core-shell particle according to an embodiment.

In one embodiment, the spherical core-shell particle has an average particle diameter of the core of about 0.01 nm to about 300 nm, for example, about 5 nm to about 250 nm, for example, about 5 nm to about 100 nm, for example , about 5 nm to about 90 nm, such as about 5 nm to about 80 nm, such as about 20 nm to about 80 nm, such as about 40 nm to 80 nm.

the average thickness of the shell of the spherical core-shell particle is from about 1 nm to about 150 nm, such as from about 1 nm to about 120 nm, such as from about 1 nm to about 100 nm, such as from about 1 nm to about 80 nm, For example, from about 5 nm to about 80 nm, such as from about 10 nm to about 80 nm, such as from about 10 nm to about 70 nm, such as from about 20 nm to about 60 nm, such as from about 30 nm to about 60 nm, For example, it may be about 40 nm to about 60 nm.

In the spherical core-shell particle, the aspect ratio defined as the ratio (L/S) of the major axis (L) and the minor axis (S) of the core based on the cross section is from about 1.00 to about 2.00, for example For example, from about 1.00 to about 1.80, such as from about 1.00 to about 1.75, such as from about 1.00 to about 1.70, such as from about 1.00 to about 1.65, such as from about 1.00 to about 1.60 have.

In one embodiment, the rod-shaped core-shell particle has an average width of the core of about 0.01 nm to about 100 nm, for example, about 5 nm to about 100 nm, for example, about 5 nm to about 90 nm , for example, about 5 nm to about 80 nm, such as about 20 nm to about 80 nm, such as about 40 nm to 80 nm.

The average thickness of the shell of the rod-shaped core-shell particle is from about 1 nm to about 150 nm, such as from about 1 nm to about 120 nm, such as from about 1 nm to about 100 nm, such as from about 1 nm to about 80 nm. , for example from about 5 nm to about 80 nm, such as from about 10 nm to about 80 nm, such as from about 10 nm to about 70 nm, such as from about 20 nm to about 60 nm, such as from about 30 nm to about 60 nm , for example, from about 40 nm to about 60 nm.

In the rod-shaped core-shell particle, the aspect ratio defined as the ratio (L/W) of the length (L) and width (W) of the core is greater than about 2.00, about 40.00 or less, for example , from about 5.00 to about 40.00, such as from about 10.00 to about 40.00, such as from about 15.00 to about 35.00.

In the structure of the spherical core-shell particle and the rod-shaped core-shell particle, the average particle diameter of the core, the average width of the core, the average thickness of the shell, the major and minor diameters of the core, and the length of the core and width are both two-dimensional values measured with respect to the cross section of the particle, and can be obtained from a projection image obtained through means such as a scanning electron microscope (SEM) or a transmission electron microscope (TEM). In the average particle diameter of the core, the average width of the core, and the average thickness of the shell, 'average' means 'number average'. In the spherical core-shell particle, for any one core, the longest particle diameter is defined as the major diameter of the core, and the shortest particle diameter is defined as the minor diameter of the core. In the rod-shaped core-shell particle, the relatively longer length among the width and length of any one core is referred to as the length of the core, and the relatively short length is referred to as the width of the core. In the spherical and rod-shaped core-shell particles, the thickness of the shell means a vertical straight line distance from the interface between the core and the shell to the outer surface of the shell.

In one embodiment, the chiral nanostructure may be manufactured by application of a helical magnetic field. Specifically, the chiral nanostructure may be a structure prepared by applying a helical magnetic field to a nanoparticle dispersion of non-chirality. That is, not only the existing chirality of the chiral nanostructure is variable by the application of the helical magnetic field, but also the initial chirality itself may be imparted by the application of the helical magnetic field. More specifically, the chiral nanostructure is formed by disposing a non-chiral nanoparticle dispersion in which nanoparticles are irregularly dispersed in a dispersion medium in a helical magnetic field formed between two magnetic bodies that rotate relative to each other at a predetermined rotation angle (θ). It can be prepared as a nanostructure having irrationality.

In one embodiment, the chiral nanostructure may be in a form present in a solvent or a dispersion medium.

In one embodiment, the nanoparticles include magnetic plasmon particles, and the magnetic plasmon particles include a core; and a core-shell particle surrounding at least a part of the core and having a shell including a component different from the component of the core, wherein the value of the following formula 1 of the chiral nanostructure This 0 to 20 can be satisfied.

[Equation 1]

In Equation 1, A is the ratio of the average core particle diameter (nm) to the shell average thickness (nm) of the nanoparticles; or the ratio of the average core width (nm) to the shell average thickness (nm), B is the concentration (μg/mL) value of the nanoparticles, and C is the helical magnetic field applied to the chiral nanostructure. When the rotation angle (θ) is 45°, the ratio of the relative chirality size when the size value of the chirality (τ) is 1.0, and the P _max is the B and C is the absolute value of the maximum peak value of the Circular Dichroism Spectroscopy under condition.

In one embodiment, the value of Equation 1 may be a result when B is any one of about 25 to about 200 and C is any one of about 0 to about 1.0. When the value of Equation 1 derived from such concentration and angle conditions satisfies the range of about 0 to about 20, the value of Equation 1 and the real-time chiral variability and structural integrity of the chiral nanostructure will be greatly improved. can

The value of Formula 1 does not have to satisfy about 0 to about 20 in all the aforementioned ranges of B and C, but any one value of B and any one value of C in each of the aforementioned ranges. When a specific value within the range of about 0 to about 20 is satisfied, the chiral nanostructure may be an indicator indicating that the desired real-time variability and structural chiral integrity are secured. However, the real-time variability and structural chiral integrity are improved as the number of cases in which the range of the value of Equation 1 satisfies the corresponding range within the aforementioned ranges of B and C increases.

When the nanoparticles are spherical core-shell particles, A is a value of the ratio (D/T) of the average core particle diameter (D) to the average shell thickness (T). When the nanoparticles are rod-shaped core-shell particles, A is a value of the ratio (W/T) of the average core width (W) to the average shell thickness (T).

B is the concentration (μg/mL) value of nanoparticles in the chiral nanostructure. As described above, in one embodiment, the chiral nanostructure may be in a form present in a solvent or a dispersion medium, that is, in a state of a kind of colloidal solution. B is the concentration (μg/mL) value of nanoparticles in the solution. Specifically, when preparing the chiral nanostructure from a non-chiral nanoparticle dispersion; and applying a magnetic field to impart different chirality to the chiral nanostructure; All of the above B may be defined as the concentration (μg/mL) value of the nanoparticles in the solution.

C is the ratio of relative chirality magnitudes when the magnitude value of chirality τ is 1.0 when the rotation angle θ of the helical magnetic field applied to the chiral nanostructure is 45°. More specifically, the rotation angle θ may mean a rotation angle θ of two magnetic materials that are relatively rotated to form the spiral magnetic field. The chirality of the chiral nanostructure may be imparted by application of a helical magnetic field. In addition, as described above, the chiral nanostructure may have a characteristic in which chirality is changed by application of a helical magnetic field. When a helical magnetic field is applied to the nanostructure to impart or change chirality, the helical magnetic field may be formed by relative rotation of two opposing magnetic materials. As the rotation angle θ of the two magnetic materials changes, the chirality of the nanostructure also changes.

Specifically, the magnitude of the chirality (τ) of the spiral magnetic field may be proportional to the magnitude value of sin(2θ). For example, when the respective rotation angle θ of the two magnetic materials is 15°; and the ratio of the relative magnitudes of the chirality in the case of 165° is 0.5 based on the magnitude of the chirality (τ) of 1.0 when the rotation angle θ of the helical magnetic field is 45°.

The Pmax is a maximum peak value (mdeg) when a circular dichroism spectroscopy of the chiral nanostructure is measured. For example, when two or more peaks are derived from different wavelength regions, it means a value for one peak having the largest absolute value of the peak value. The Pmax is an absolute value and is expressed as a positive (+) value.

In one embodiment, when the value of Equation 1 satisfies about 0 to about 20 in the chiral nanostructure, it is possible to implement an effect of significantly faster modulation speed of chirality compared to the prior art, and substantially real-time variable magnetism It can be assembled.

In one embodiment, when the nanoparticles include spherical core-shell particles and the shell has a structure substantially surrounding the entire surface of the core, the value of Equation 1 is about 0 to about 3.0, for example , from about 0 to about 2.5, such as from about 0 to about 1.5, such as from about 0 to about 1.0. In this case, for example, the nanoparticles may include a core including a metal component; and a core-shell particle having a shell including a magnetic component.

When the nanoparticles include spherical core-shell particles, the shell has a structure substantially surrounding the entire surface of the core, and C is any value greater than 0 (zero), the value of Equation 1 is from about 0.01 to about 3.5, such as from about 0.01 to about 3.0, such as from about 0.01 to about 2.5, such as from about 0.01 to about 1.5, such as from about 0.01 to about 1.0.

The nanoparticles include spherical core-shell particles, the shell has a structure substantially surrounding the entire surface of the core, the C is any value greater than 0 (zero), and the B is 50 to 200 In the case of any one of the values in the range, the value of Equation 1 may be from about 0.01 to about 1.0, for example, from about 0.01 to about 0.80, for example, from about 0.01 to about 0.50.

In another embodiment, when the nanoparticles include spherical core-shell particles, and the shell has a half-shell structure substantially surrounding a portion of the surface of the core, the value of Equation 1 is about 0 to about 19.00 may be, for example, from about 0 to about 18.00, for example, from about 0 to about 17.00. In this case, for example, the nanoparticles may include a core including a magnetic component; and a core-shell particle having a shell including a metal component.

When the nanoparticles include spherical core-shell particles, the shell is a half-shell structure substantially surrounding a part of the surface of the core, and C is any one value greater than 0 (zero), the formula The value of 1 can be from about 1.00 to about 19.00, for example, from about 1.50 to about 19.00, for example, from about 2.00 to about 18.00, for example, from about 2.50 to about 17.00. have.

The nanoparticles include spherical core-shell particles, the shell has a half-shell structure substantially surrounding a part of the surface of the core, and C is any value greater than 0 (zero), and the B When is any value in the range of 50 to 200, the value of Equation 1 may be from about 1.00 to about 17.00, for example, from about 1.00 to 15.00, for example, from about 1.00 to 14.00. .

In another embodiment, when the nanoparticles include rod-shaped core-shell particles and the shell has a structure substantially surrounding the entire surface of the core, the value of Equation 1 may be about 0 to about 3.0 have. In this case, for example, the nanoparticles may include a core including a metal component; and a core-shell particle having a shell including a magnetic component.

When the nanoparticles include rod-shaped core-shell particles, the shell has a structure substantially surrounding the entire surface of the core, and C is any value greater than 0 (zero), the value of Equation 1 about 0.1 to about 3.5, such as about 0.1 to about 3.0, such as about 0.2 to about 3.5, such as about 0.2 to about 3.5, such as about 0.3 to about 3.5, such as , from about 0.3 to about 3.0.

The nanoparticles include rod-shaped core-shell particles, the shell has a structure substantially surrounding the entire surface of the core, the C is any value greater than 0 (zero), and the B is 75 to When it is any one value in the range of 200, the value of Equation 1 may be from about 0.1 to about 3.0, for example, from about 0.1 to about 2.0, for example, from about 0.1 to about 1.8.

As described above, the chiral nanostructure has chirality derived from the structural characteristics of the nanoparticle array structure, and the chirality may be imparted by application of a helical magnetic field. In addition, the chiral nanostructure may exhibit a feature that can be modulated with chiral properties different from the existing chiral properties by applying a helical magnetic field. Such structural chirality and real-time self-assembly of the chiral nanostructure has the advantage of significantly expanding the field of technology to which it can be applied.

Hereinafter, a method for manufacturing the nanostructure will be described in detail.

The nanostructure may be formed by forming a magnetic field; A particle disposing step of disposing at least two or more nanoparticles in a magnetic field; and a magnetic field adjusting step of adjusting at least one of a magnetic flux density, a magnetization direction, and a spatial range of the magnetic field, wherein in the magnetic field adjusting step, the arrangement of the nanoparticles disposed in the magnetic field is aligned to correspond to the structure of the magnetic field It can be manufactured by a method in which the entire structure is formed into a nanostructure having chirality.

In the magnetic field forming step, the magnetic field is not particularly limited as long as the magnetic field has a structure capable of finally imparting chirality to the nanostructure, but may be, for example, a magnetic field of a spiral structure. When the magnetic field is a helical magnetic field, it has chirality due to a helical structure. In this case, structural chirality induced from the magnetic field may be transferred to the nanoparticles, and thus the aligned structure of the nanoparticles may be manufactured to have chirality resulting from the helical structure.

5 is a schematic diagram schematically illustrating a method of manufacturing the nanostructure according to an embodiment.

For example, in the magnetic field forming step, the magnetic field may be a spiral magnetic field 13 formed by relatively rotating at least two magnetic materials 11 and 12 . The two magnetic materials 11 and 12 are arranged to face each other in the same magnetization direction (y-axis direction), and then rotate in opposite directions with an axis passing through each center (y-axis) as a rotation axis, and a spiral magnetic field 13 ) can be formed.

6 is a schematic diagram illustrating a case in which the two magnetic materials 11 and 12 are respectively rotated in opposite directions in the y-axis direction. 6, one magnetic body 11 rotates clockwise so that the angle θ1 between its long axis L1 and the z-axis is in the range of 0° < θ1 < 180°, and the other magnetic material ( 12) It can be rotated counterclockwise so that the angle θ2 between the long axis L2 and the z axis is in the range of 0°>θ2>-180°. By adjusting the θ1 and θ2, the structure of the spiral magnetic field may be determined.

In one embodiment, the two magnetic materials 11 and 12 may be rotated so that the absolute values of θ1 and θ2 have the same magnitude. In addition, the structure of the spiral magnetic field 13 may be determined by adjusting the magnitudes of θ1 and θ2. The spiral magnetic field 13 exhibits chirality by having a mirror surface asymmetric structure, and the degree of chirality may be adjusted according to the sizes of θ1 and θ2 . When the magnitudes of the absolute values of θ1 and θ2 are referred to as θ, the magnitude of the chirality of the spiral magnetic field 13 may be proportional to the magnitude of sin(2θ).

In one embodiment, the two magnetic materials 11 and 12 may each independently include a neodymium magnet, a ferrite magnet, or an electromagnet. Specifically, the magnetic flux density of the magnetic material may be from about 1 μT to about 5T, for example, from about 0.01T to about 0.4T, for example, from about 0.01T to about 0.3T.

In one embodiment, the magnetic material separation distance defined as a straight line distance connecting the centers of the two magnetic materials 11 and 12 may be about 1 μm to about 10 m, for example, about 1 μm to about 5 m, For example, it can be from about 1 μm to about 1 m, for example, from 1 μm to about 80 cm, for example, from about 1 cm to about 50 cm, for example, from about 1 cm to about 10 cm. can be, for example, from about 1 cm to about 8 cm, for example, from about 1 cm to about 6 cm, for example, from about 1 cm to about 5 cm, for example, from about 1 cm to about 1 cm It may be 4 cm.

The method of manufacturing the nanostructure includes a particle arrangement step of disposing at least two or more nanoparticles in a magnetic field. 7 schematically illustrates the particle placement step 20 .

The particle arrangement step 20 is a step of disposing target particles for imparting chirality in the magnetic field generated in the magnetic field forming step. The particle disposing step may be performed before the magnetic field forming step, or may be performed after the magnetic field forming step. That is, the nanoparticles may be disposed in a region in which a magnetic field is to be formed in advance before the magnetic field is formed, or may be disposed in a region in which a magnetic field is formed after the magnetic field is formed.

All matters regarding the nanoparticles are the same as those described above with respect to the chiral nanostructure.

7 illustrates, by way of example, a case in which particles are disposed before the magnetic field forming step. Referring to FIG. 7 , in the particle disposing step 20 , the nanoparticles may be disposed in the magnetic field while being dispersed in a solvent or dispersion medium. Specifically, after preparing the colloidal solution 21 including at least two or more of the nanoparticles, the method may be performed by disposing the colloidal solution 21 in the magnetic field.

The concentration of the nanoparticles in the colloidal solution 21 may be about 5 μg/mL to about 500 mg/mL, for example, about 5 μg/mL to about 400 mg/mL, for example, about 10 mg/mL to about 400 mg/mL. By dispersing the nanoparticles in the above-mentioned concentration range and applying to the manufacturing method, it may be advantageous for the nanoparticles to be arranged in an aligned structure having chirality without agglomeration, and three-dimensional (3D) consisting of at least two or more of the nanoparticles of chiral nanostructures can be precisely formed.

The solvent or dispersion medium may include one selected from the group consisting of distilled water, deionized water, alcohol, organic solvents, polymers, and combinations thereof, but is not limited thereto. The 'polymer' is a polymer having a weight average molecular weight (Mw) of about 500 or more, and may have a viscosity of about 5 cP to 6000 cP at room temperature, and may be composed of one type or a mixture of two or more types, and function as a dispersion medium for the nanoparticles. It is understood to be a generic term for any hydrophilic, hydrophobic, or amphiphilic liquid or solid polymer that can be used.

The method of manufacturing the chiral nanostructure includes a magnetic field adjusting step of adjusting at least one of a magnetic flux density, a magnetization direction, and a spatial range of the magnetic field. The magnetic field adjusting step is a step of imparting a desired level of chirality to the nanoparticles disposed in the magnetic field by changing the magnetic field formed in the magnetic field forming step. The magnetic field adjustment step may be performed simultaneously with the magnetic field formation step, or may be performed with a predetermined time difference. That is, in the magnetic field forming step, a magnetic field having a desired structure may be formed by controlling at least one of a magnetic flux density, a magnetization direction, and a spatial range thereof at the same time as the magnetic field is formed; Alternatively, the magnetic field initially formed in the magnetic field formation step may be formed into a magnetic field having a different structure by adjusting at least one of a magnetic flux density, a magnetization direction, and a spatial range thereof later. For example, the former case may include a case in which chirality is first given to a non-chiral nanoparticle dispersion, and in the latter case, a different chirality is imparted to an existing nanostructure having chirality. It may include cases for

In the magnetic field adjustment step, the arrangement of the nanoparticles arranged in the magnetic field is changed so that the final alignment structure thereof is adjusted to correspond to the chirality of the magnetic field, thereby finally forming a nanostructure having chirality. If the arrangement of the nanoparticles disposed in the magnetic field is aligned to correspond to the structure of the magnetic field, the arrangement structure by the arrangement of the nanoparticles does not have chirality, but the chirality of the magnetic field is transferred to chiral It means to have a sex or to have a chirality different from the existing chirality.

When the magnetic field formed in the magnetic field forming step is, for example, a helical magnetic field, it has chirality induced from a mirror surface asymmetric structure. In this case, at least two or more nanoparticles disposed in the magnetic field may transfer the structural chirality of the spiral magnetic field through an arrangement change by the magnetic field to form an aligned structure having substantially the same level of chirality. Therefore, when at least one of the magnetic flux density, the magnetization direction, and the spatial range of the magnetic field is changed, the chirality of the magnetic field is changed, and accordingly, the chirality of the aligned structure of the nanoparticles disposed in the magnetic field is also changed will do For example, when the magnetic flux density is increased in the magnetic field control step, a peak on a circular dichroism spectroscopy graph of the nanostructure is moved to a shorter wavelength side.

For example, in the magnetic field forming step, the magnetic field may be a spiral magnetic field formed by relatively rotating at least two magnetic bodies, and the angle at which the at least two magnetic bodies are relatively rotated in the magnetic field adjusting step; and changing at least one of the degree of parallelism of the at least two magnetic materials to adjust the magnetization direction of the magnetic field.

For example, in the magnetic field forming step, the magnetic field may be a spiral magnetic field formed by relatively rotating at least two magnetic materials, and in the magnetic field adjusting step, the spatial range of the magnetic field is changed by changing the linear distance between the at least two magnetic materials can be adjusted

For example, in the magnetic field forming step, the magnetic field may be a spiral magnetic field formed by relatively rotating at least two magnetic materials, and in the magnetic field adjusting step, magnetic force of the at least two magnetic materials; and changing at least one of a linear distance between the at least two magnetic bodies to adjust the magnetic flux density of the magnetic field.

Through the manufacturing method of the chiral nanostructure, it is possible to manufacture the chiral nanostructure as described above. In addition, a chiral nanostructure satisfying Equation 1 below may be manufactured through the method of manufacturing the chiral nanostructure.

[Equation 1]

In Equation 1, A is the ratio of the average core particle diameter (nm) to the shell average thickness (nm) of the nanoparticles; or the ratio of the average core width (nm) to the shell average thickness (nm), B is the concentration (μg/mL) value of the nanoparticles, and C is the helical magnetic field applied to the chiral nanostructure. When the rotation angle (θ) is 45°, the ratio of the relative chirality size when the size value of the chirality (τ) is 1.0, and the P _max is the B and C is the absolute value of the maximum peak value of the Circular Dichroism Spectroscopy under condition.

The description of Equation 1 and each factor constituting it is the same as described above in relation to the chiral nanostructure.

Hereinafter, specific examples of the present invention are presented. However, the examples described below are only for specifically illustrating or explaining the present invention, and thus the scope of the present invention is not limited and interpreted, and the scope of the present invention is determined by the claims.

<Production Example>

Preparation Example 1: Synthesis of spherical core-shell nanoparticles (1)

A mixed solution was prepared by mixing 3.2 mmol of iron nitrate (Fe(NO ₃ ) ₃ ·9H ₂ O) with 40 mL of ethylene glycol (C ₂ H ₄ (OH) ₂ ) and stirring with a magnetic stirrer until completely dissolved. 35 mmol of sodium acetate (CH ₃ COONa) and 0.59 mmol of silver nitrate (AgNO ₃ ) were added to the mixed solution, and stirring was continued. When sodium acetate and silver nitrate are all dissolved, transfer the mixed solution to a Teflon container, put it in a metal container to withstand the pressure, and then heat to 210°C and keep for 4 hours. After the reaction, the synthesized nanoparticles are separated by centrifugation, etc., and purified with ethanol and deionized water. The separated nanoparticles are dried in a vacuum oven for 12 hours to prepare a powder.

Then, in order to disperse the nanoparticles in a polar solvent such as deionized water, a surface pretreatment step of attaching a hydrophilic functional group to the surface of the nanoparticles is performed. 1 mg of the nanoparticles in the form of powder made in the nanoparticle synthesis step and 0.6 mg of citric acid (HOC(COOH)(CH ₂ COOH) ₂ ) were placed in 1 mL of deionized water, sonicated for 2 hours, and then the nanoparticles were separated by centrifugation, etc. The particles are separated and purified with deionized water.

Preparation Example 2: Synthesis of spherical core-shell nanoparticles (2)

A mixed solution was prepared by mixing 1.6 mmol of iron nitrate (Fe(NO ₃ ) ₃ .9H ₂ O) with 40 mL of ethylene glycol (C ₂ H ₄ (OH) ₂ ) and stirring with a magnetic stirrer until completely dissolved. 35 mmol of sodium acetate (CH ₃ COONa) and 0.59 mmol of silver nitrate (AgNO ₃ ) were added to the mixed solution, and stirring was continued. When sodium acetate and silver nitrate are all dissolved, transfer the mixed solution to a Teflon container, put it in a metal container to withstand the pressure, and then heat to 210°C and keep for 4 hours. After the reaction, the synthesized nanoparticles are separated by centrifugation, etc., and purified with ethanol and deionized water. The separated nanoparticles are dried in a vacuum oven for 12 hours to prepare a powder.

Then, in order to disperse the nanoparticles in a polar solvent such as deionized water, a surface pretreatment step of attaching a hydrophilic functional group to the surface of the nanoparticles is performed. 1 mg of the nanoparticles in the form of powder made in the nanoparticle synthesis step and 0.6 mg of citric acid (HOC(COOH)(CH ₂ COOH) ₂ ) were placed in 1 mL of deionized water, sonicated for 2 hours, and then the nanoparticles were separated by centrifugation, etc. The particles are separated and purified with deionized water.

Preparation Example 3: Synthesis of rod-shaped core-shell nanoparticles

4.0mmol of iron chloride (FeCl ₃ ·6H ₂ O) was mixed with 40 mL of ethylene glycol (C ₂ H ₄ (OH) ₂ ) and stirred with a magnetic stirrer until completely dissolved to prepare a mixed solution. 35 mmol of sodium acetate (CH ₃ COONa) and 0.59 mmol of chloroauric acid (HAuCl ₄ ·3H ₂ O) were added to the mixed solution, and stirring was continued. When sodium acetate and chloroauric acid are all dissolved, transfer the mixed solution to a Teflon container, put it in a metal container to withstand pressure, and then heat to 200°C and keep for 8 hours. After the reaction, the synthesized nanoparticles are separated by centrifugation, etc., and purified with ethanol and deionized water. The separated nanoparticles are dried in a vacuum oven for 12 hours to prepare a powder.

Then, in order to disperse the nanoparticles in a polar solvent such as deionized water, a surface pretreatment step of attaching a hydrophilic functional group to the surface of the nanoparticles is performed. 1 mg of the nanoparticles in the form of powder made in the nanoparticle synthesis step and 0.6 mg of citric acid (HOC(COOH)(CH ₂ COOH) ₂ ) were placed in 1 mL of deionized water, sonicated for 2 hours, and then the nanoparticles were separated by centrifugation, etc. The particles are separated and purified with deionized water.

Preparation Example 4: Synthesis of spherical half-shell nanoparticles

20 mL of ethylene glycol (C ₂ H ₄ (OH) ₂ ) solution is mixed with 0.12 M of iron chloride (Fe(NO ₃ ) ₃ 9H ₂ O) and 34 mM citric acid, and stirred with a magnetic stirrer until completely dissolved. was prepared. Sodium acetate (CH ₃ COONa) is added to the mixed solution to adjust the concentration to 0.73 M. When all sodium acetate is dissolved, transfer the mixed solution to a Teflon container, put it in a metal container to withstand the pressure, and then heat to 200°C and keep for 10 hours. After the reaction, the synthesized nanoparticles are separated by centrifugation, etc., and purified with ethanol and deionized water. The separated nanoparticles are dried in a vacuum oven for 12 hours to prepare a powder.

Then, in order to disperse the nanoparticles in a polar solvent such as deionized water, a surface pretreatment step of attaching a hydrophilic functional group to the surface of the nanoparticles is performed. 1 mg of the nanoparticles in the form of powder made in the nanoparticle synthesis step and 0.6 mg of citric acid (HOC(COOH)(CH ₂ COOH) ₂ ) were placed in 1 mL of deionized water, sonicated for 2 hours, and then the nanoparticles were separated by centrifugation, etc. The particles are separated and purified with deionized water.

The slide glass is treated with a piranha solution to remove organic matter and foreign substances to prepare a hydrophilic surface. The slide glass is immersed in 0.2 wt% polydiallyldimethylammonium chloride (PDDA) polymer solution so that the positively charged polyvinyl alcohol (PVA, polyvinylalcohol) polymer can be evenly distributed on the slide glass surface. After that, take out the glass slide and dry it, then drop the prepared magnetic nanoparticle solution so that the negatively charged nanoparticles can be uniformly attached to the positively charged PDDA surface, and the remaining solutions are gently washed with deionized water and dried. A coating of about 20 nm is applied to nanoparticles arranged on the slide glass as a single layer using gold sputtering. Thereafter, in order to stabilize the surface of the coated gold thin film, cysteine at a concentration of 1 mg/mL was added in excess and reacted for 12 hours at 60 rpm in a shaking incubator. After the reaction is completed, the nanoparticle monolayer is removed from the slide glass by ultrasonic treatment, the nanoparticles are separated with a magnet, and purified with deionized water.

<Example>

Example 1: Chiral Nanostructure Containing Spherical Core-Shell Nanoparticles (1)

A spherical core-shell nanoparticle having a core containing silver (Ag) and a shell containing iron oxide (Fe ₃ O ₄ ) was prepared. The average diameter of the core is 61.4 (± 13.3) nm, and the average thickness of the shell is 54.3 (± 5.7) nm. Non-chiral nanoparticle dispersions were prepared by dispersing the nanoparticles in a solvent of deionized water so as to have respective concentrations as shown in Table 1 below. Two neodymium (neodymium) magnets (50 x 10 x 2 mm, 0.2T) were prepared, and as shown in FIG. 5 , they were disposed to face each other at an interval of 3 cm in the same magnetization direction (y-axis direction). Each concentration of the achiral nanoparticle dispersion was placed in the center between the two magnets as shown in FIG. 7 . The two magnets were rotated by the same angular size using the y-axis as the rotation axis, one magnet was rotated clockwise and the other magnet was rotated counterclockwise. The size of the angle between the long axis of each magnet and the z-axis, that is, the size of the rotation angle θ, was rotated as shown in Table 1 below. Thus, the chiral nanostructure of Example 1 was prepared.

Concentration (B)
[μg/mL] θ
[°] τ Relative Ratio (C)
(|sin2θ|)
[θ=degree] CD spectrum [mdeg] (A*B*C)/Pmax
(A=61.4/54.3) @ around 680nm @ around 830nm Pmax Example 1-1 25 0 0.00 24.0099 -27.7944 27.7944 0.00 Example 1-2 50 0 0.00 -1.18151 -3.35958 3.35958 0.00 Examples 1-3 75 0 0.00 67.0504 -117.419 117.419 0.00 Examples 1-4 100 0 0.00 95.599 -174.176 174.176 0.00 Examples 1-5 125 0 0.00 59.8761 -168.584 168.584 0.00 Examples 1-6 150 0 0.00 62.7865 -196.911 196.911 0.00 Examples 1-7 175 0 0.00 41.5222 -158.031 158.031 0.00 Examples 1-8 200 0 0.00 24.2616 -142.455 142.455 0.00 Examples 1-9 25 15 0.50 -4.5823 14.4494 14.4494 0.98 Examples 1-10 50 15 0.50 -85.6535 220.452 220.452 0.13 Examples 1-11 75 15 0.50 -131.236 324.921 324.921 0.13 Examples 1-12 100 15 0.50 -261.17 721.541 721.541 0.08 Examples 1-13 125 15 0.50 -404.182 1147.69 1147.69 0.06 Examples 1-14 150 15 0.50 -443.853 1276.1 1276.1 0.07 Examples 1-15 175 15 0.50 -245.245 818.711 818.711 0.12 Examples 1-16 200 15 0.50 -415.379 1174.39 1174.39 0.10 Examples 1-17 25 30 0.87 -22.7185 79.474 79.474 0.31 Examples 1-18 50 30 0.87 -121.04 417.616 417.616 0.12 Examples 1-19 75 30 0.87 -272.214 646.457 646.457 0.11 Examples 1-20 100 30 0.87 -490.672 1414.71 1414.71 0.07 Example 1-21 125 30 0.87 -678.063 2063.78 2063.78 0.06 Example 1-22 150 30 0.87 -634.406 1913.76 1913.76 0.08 Example 1-23 175 30 0.87 -825.094 2361.52 2361.52 0.07 Example 1-24 200 30 0.87 -755.049 2214.15 2214.15 0.09 Examples 1-25 25 45 1.00 -20.9936 76.835 76.835 0.37 Example 1-26 50 45 1.00 -140.436 511.409 511.409 0.11 Example 1-27 75 45 1.00 -306.815 1080.49 1080.49 0.08 Example 1-28 100 45 1.00 -591.983 1926.45 1926.45 0.06 Example 1-29 125 45 1.00 -742.859 2263.11 2263.11 0.06 Examples 1-30 150 45 1.00 -722.538 2269.08 2269.08 0.07 Examples 1-31 175 45 1.00 -941.641 2738.09 2738.09 0.07 Examples 1-32 200 45 1.00 -1018.3 2892.83 2892.83 0.08 Examples 1-33 25 60 0.87 -20.8995 73.6665 73.6665 0.33 Examples 1-34 50 60 0.87 -88.4849 346.019 346.019 0.14 Examples 1-35 75 60 0.87 -276.003 781.403 781.403 0.09 Examples 1-36 100 60 0.87 -502.098 1540.75 1540.75 0.06 Examples 1-37 125 60 0.87 -655.969 2052.61 2052.61 0.06 Examples 1-38 150 60 0.87 -710.642 2167.07 2167.07 0.07 Examples 1-39 175 60 0.87 -780.289 2379.01 2379.01 0.07 Examples 1-40 200 60 0.87 -848.356 2460.57 2460.57 0.08 Examples 1-41 25 75 0.50 -0.245546 24.6635 24.6635 0.57 Examples 1-42 50 75 0.50 -36.2108 158.793 158.793 0.18 Examples 1-43 75 75 0.50 -143.936 461.295 461.295 0.09 Examples 1-44 100 75 0.50 -262.514 825.693 825.693 0.07 Examples 1-45 125 75 0.50 -359.163 1140.66 1140.66 0.06 Examples 1-46 150 75 0.50 -357.154 1284.65 1284.65 0.07 Examples 1-47 175 75 0.50 -436.247 1330.04 1330.04 0.07 Examples 1-48 200 75 0.50 -399.246 1214.5 1214.5 0.09 Examples 1-49 25 90 0.00 16.0777 -44.0767 44.0767 0.00 Examples 1-50 50 90 0.00 28.9884 -64.2371 64.2371 0.00 Examples 1-51 75 90 0.00 52.7822 -126.687 126.687 0.00 Examples 1-52 100 90 0.00 60.1336 -105.996 105.996 0.00 Examples 1-53 125 90 0.00 60.7256 -132.183 132.183 0.00 Example 1-54 150 90 0.00 44.4219 -102.583 102.583 0.00 Examples 1-55 175 90 0.00 54.9442 -120.422 120.422 0.00 Examples 1-56 200 90 0.00 28.7288 -86.9 86.9 0.00 Examples 1-57 25 105 0.50 34.9145 -105.617 105.617 0.13 Examples 1-58 50 105 0.50 74.5349 -224.161 224.161 0.13 Examples 1-59 75 105 0.50 231.221 -719.515 719.515 0.06 Examples 1-60 100 105 0.50 381.372 -1127.94 1127.94 0.05 Example 1-61 125 105 0.50 493.191 -1466.55 1466.55 0.05 Examples 1-62 150 105 0.50 472.662 -1430.01 1430.01 0.06 Examples 1-63 175 105 0.50 479.217 -1467.72 1467.72 0.07 Examples 1-64 200 105 0.50 440.318 -1416.95 1416.95 0.08 Examples 1-65 25 120 0.87 44.0728 -147.612 147.612 0.17 Example 1-66 50 120 0.87 115.376 -398.886 398.886 0.12 Example 1-67 75 120 0.87 348.892 -1100.23 1100.23 0.07 Examples 1-68 100 120 0.87 570.329 -1844.23 1844.23 0.05 Examples 1-69 125 120 0.87 803.536 -2343.33 2343.33 0.05 Example 1-70 150 120 0.87 754.928 -2261.11 2261.11 0.06 Example 1-71 175 120 0.87 899.43 -2568.77 2568.77 0.07 Example 1-72 200 120 0.87 905.293 -2470.57 2470.57 0.08 Example 1-73 25 135 1.00 51.5963 -186.348 186.348 0.15 Example 1-74 50 135 1.00 165.941 -582.582 582.582 0.10 Example 1-75 75 135 1.00 414.199 -1300.25 1300.25 0.07 Example 1-76 100 135 1.00 680.842 -2144.71 2144.71 0.05 Example 1-77 125 135 1.00 805.463 -2502.3 2502.3 0.06 Example 1-78 150 135 1.00 882.054 -2601.23 2601.23 0.07 Example 1-79 175 135 1.00 1071.95 -3049.28 3049.28 0.06 Example 1-80 200 135 1.00 958.416 -2714.1 2714.1 0.08 Example 1-81 25 150 0.87 48.8084 -159.532 159.532 0.15 Example 1-82 50 150 0.87 154.376 -515.826 515.826 0.09 Example 1-83 75 150 0.87 375.085 -1174.04 1174.04 0.06 Example 1-84 100 150 0.87 599.926 -1900.42 1900.42 0.05 Example 1-85 125 150 0.87 757.317 -2261.12 2261.12 0.05 Example 1-86 150 150 0.87 719.947 -2231.19 2231.19 0.07 Examples 1-87 175 150 0.87 1072.8 -2985.31 2985.31 0.06 Example 1-88 200 150 0.87 999.777 -2777.72 2777.72 0.07 Example 1-89 25 165 0.50 37.7221 -117.342 117.342 0.12 Examples 1-90 50 165 0.50 96.7212 -317.234 317.234 0.09 Example 1-91 75 165 0.50 241.131 -748.105 748.105 0.06 Example 1-92 100 165 0.50 370.313 -1163.1 1163.1 0.05 Example 1-93 125 165 0.50 530.478 -1494.5 1494.5 0.05 Example 1-94 150 165 0.50 470.297 -1417.91 1417.91 0.06 Example 1-95 175 165 0.50 708.259 -1794.61 1794.61 0.06 Examples 1-96 200 165 0.50 471.786 -1363.09 1363.09 0.08 Maximum value of (A*B*C)/Pmax 0.98 Minimum value of (A*B*C)/Pmax 0.00 If C>0, the minimum value of (A*B*C)/Pmax 0.05

Example 2: Chiral Nanostructure Containing Spherical Core-Shell Nanoparticles (2)

A spherical core-shell nanoparticle having a core containing silver (Ag) and a shell containing iron oxide (Fe ₃ O ₄ ) was prepared. The average diameter of the core is 50.2 (± 12.2) nm, and the average thickness of the shell is 56.3 (± 7.4) nm. Non-chiral nanoparticle dispersions were prepared by dispersing the nanoparticles in a solvent of deionized water to have respective concentrations as shown in Table 2 below. Two neodymium (neodymium) magnets (50 x 10 x 2 mm, 0.2T) were prepared, and as shown in FIG. 5 , they were disposed to face each other at an interval of 3 cm in the same magnetization direction (y-axis direction). Each concentration of the achiral nanoparticle dispersion was placed in the center between the two magnets as shown in FIG. 7 . The two magnets were rotated by the same angular size using the y-axis as the rotation axis, one magnet was rotated clockwise and the other magnet was rotated counterclockwise. The size of the angle between the long axis of each magnet and the z-axis, that is, the size of the rotation angle θ, was rotated as shown in Table 2 below. Thus, the chiral nanostructure of Example 2 was prepared.

Concentration (B)
[μg/mL] θ
[°] τ Relative Ratio (C)
(|sin2θ|)
[θ=degree] CD spectrum [mdeg] (A*B*C)/Pmax
(A=50.2/56.3) @ around 550nm @ around 630nm Pmax Example 2-1 25 0 0.00 12.9887 -33.9227 33.9227 0.00 Example 2-2 50 0 0.00 24.0005 -69.5656 69.5656 0.00 Example 2-3 75 0 0.00 37.3188 -90.1883 90.1883 0.00 Example 2-4 100 0 0.00 44.8066 -147.669 147.669 0.00 Example 2-5 125 0 0.00 69.7232 -177.941 177.941 0.00 Example 2-6 150 0 0.00 73.5675 -232.129 232.129 0.00 Example 2-7 175 0 0.00 56.4886 -211.105 211.105 0.00 Examples 2-8 200 0 0.00 80.6551 -195.476 195.476 0.00 Examples 2-9 25 15 0.50 2.04169 19.0562 19.0562 0.58 Example 2-10 50 15 0.50 -13.2609 133.278 133.278 0.17 Example 2-11 75 15 0.50 -41.9411 319.499 319.499 0.10 Example 2-12 100 15 0.50 -71.6352 545.872 545.872 0.08 Examples 2-13 125 15 0.50 -115.016 751.164 751.164 0.07 Examples 2-14 150 15 0.50 -169.939 982.81 982.81 0.07 Examples 2-15 175 15 0.50 -252.55 1177.08 1177.08 0.07 Examples 2-16 200 15 0.50 -286.668 1196.82 1196.82 0.07 Example 2-17 25 30 0.87 -4.94052 55.0064 55.0064 0.35 Example 2-18 50 30 0.87 -21.8273 221.683 221.683 0.17 Examples 2-19 75 30 0.87 -66.9534 527.974 527.974 0.11 Examples 2-20 100 30 0.87 -140.085 898.497 898.497 0.09 Example 2-21 125 30 0.87 -201.536 1187.15 1187.15 0.08 Example 2-22 150 30 0.87 -285.584 1619.41 1619.41 0.07 Example 2-23 175 30 0.87 -433.604 2225.84 2225.84 0.06 Example 2-24 200 30 0.87 -486.3 2106.9 2106.9 0.07 Examples 2-25 25 45 1.00 -0.08542 55.9676 55.9676 0.40 Example 2-26 50 45 1.00 -21.1961 212.854 212.854 0.21 Example 2-27 75 45 1.00 -74.4058 589.566 589.566 0.11 Example 2-28 100 45 1.00 -155.121 1046.21 1046.21 0.09 Example 2-29 125 45 1.00 -210.311 1297.41 1297.41 0.09 Examples 2-30 150 45 1.00 -345.387 1916.35 1916.35 0.07 Example 2-31 175 45 1.00 -497.619 2605.74 2605.74 0.06 Example 2-32 200 45 1.00 -605.706 2554.89 2554.89 0.07 Example 2-33 25 60 0.87 0.161611 46.2883 46.2883 0.42 Example 2-34 50 60 0.87 -14.1837 166.475 166.475 0.23 Example 2-35 75 60 0.87 -53.0223 451.453 451.453 0.13 Example 2-36 100 60 0.87 -108.765 793.788 793.788 0.10 Example 2-37 125 60 0.87 -149.601 967.583 967.583 0.10 Example 2-38 150 60 0.87 -270.391 1566.68 1566.68 0.07 Example 2-39 175 60 0.87 -384.997 1989.45 1989.45 0.07 Examples 2-40 200 60 0.87 -505.936 2198.12 2198.12 0.07 Example 2-41 25 75 0.50 2.59645 15.2231 15.2231 0.73 Example 2-42 50 75 0.50 -0.765858 83.6581 83.6581 0.27 Example 2-43 75 75 0.50 -20.7056 211.067 211.067 0.16 Example 2-44 100 75 0.50 -46.9466 413.847 413.847 0.11 Example 2-45 125 75 0.50 -61.347 427.492 427.492 0.13 Example 2-46 150 75 0.50 -146.882 838.844 838.844 0.08 Example 2-47 175 75 0.50 -183.78 916.749 916.749 0.08 Example 2-48 200 75 0.50 -256.047 1226.8 1226.8 0.07 Example 2-49 25 90 0.00 9.84896 -18.8676 18.8676 0.00 Examples 2-50 50 90 0.00 15.4456 -28.7567 28.7567 0.00 Example 2-51 75 90 0.00 23.4234 -56.0573 56.0573 0.00 Example 2-52 100 90 0.00 26.461 -54.7599 54.7599 0.00 Example 2-53 125 90 0.00 33.0412 -52.6661 52.6661 0.00 Example 2-54 150 90 0.00 41.7176 -77.1626 77.1626 0.00 Example 2-55 175 90 0.00 34.1409 -58.5267 58.5267 0.00 Example 2-56 200 90 0.00 55.8616 -71.8682 71.8682 0.00 Example 2-57 25 105 0.50 12.1705 -45.612 45.612 0.24 Example 2-58 50 105 0.50 27.4317 -107.644 107.644 0.21 Example 2-59 75 105 0.50 58.5299 -267.077 267.077 0.12 Examples 2-60 100 105 0.50 94.0003 -458.404 458.404 0.10 Example 2-61 125 105 0.50 103.088 -503.227 503.227 0.11 Example 2-62 150 105 0.50 194.818 -833.629 833.629 0.08 Example 2-63 175 105 0.50 241.432 -981.791 981.791 0.08 Example 2-64 200 105 0.50 350.582 -1289.48 1289.48 0.07 Example 2-65 25 120 0.87 10.1605 -57.3501 57.3501 0.34 Example 2-66 50 120 0.87 29.1265 -136.643 136.643 0.28 Example 2-67 75 120 0.87 74.073 -357.38 357.38 0.16 Example 2-68 100 120 0.87 133.365 -661.947 661.947 0.12 Example 2-69 125 120 0.87 136.452 -655.09 655.09 0.15 Example 2-70 150 120 0.87 297.667 -1342.15 1342.15 0.09 Example 2-71 175 120 0.87 351.385 -1529.56 1529.56 0.09 Example 2-72 200 120 0.87 486.754 -1796 1796 0.09 Example 2-73 25 135 1.00 12.016 -51.161 51.161 0.43 Example 2-74 50 135 1.00 30.7176 -136.684 136.684 0.33 Example 2-75 75 135 1.00 74.6721 -368.175 368.175 0.18 Example 2-76 100 135 1.00 142.527 -695.904 695.904 0.13 Example 2-77 125 135 1.00 233.812 -1073.28 1073.28 0.10 Example 2-78 150 135 1.00 309.784 -1423.48 1423.48 0.09 Example 2-79 175 135 1.00 403.784 -1806.37 1806.37 0.09 Example 2-80 200 135 1.00 545.072 -1995.66 1995.66 0.09 Example 2-81 25 150 0.87 9.68342 -46.9737 46.9737 0.41 Example 2-82 50 150 0.87 26.3462 -110.558 110.558 0.35 Example 2-83 75 150 0.87 63.2917 -275.067 275.067 0.21 Example 2-84 100 150 0.87 121.576 -502.891 502.891 0.15 Example 2-85 125 150 0.87 175.334 -793.066 793.066 0.12 Example 2-86 150 150 0.87 274.307 -1201.31 1201.31 0.10 Example 2-87 175 150 0.87 371.011 -1444.21 1444.21 0.09 Example 2-88 200 150 0.87 433.043 -1554.62 1554.62 0.10 Example 2-89 25 165 0.50 9.81558 -33.4495 33.4495 0.33 Example 2-90 50 165 0.50 17.268 -66.056 66.056 0.34 Example 2-91 75 165 0.50 34.6347 -153.61 153.61 0.22 Example 2-92 100 165 0.50 64.7832 -273.244 273.244 0.16 Example 2-93 125 165 0.50 125.247 -509.581 509.581 0.11 Example 2-94 150 165 0.50 171.555 -721.413 721.413 0.09 Example 2-95 175 165 0.50 228.764 -870.148 870.148 0.09 Example 2-96 200 165 0.50 268.001 -915.525 915.525 0.10 Maximum value of (A*B*C)/Pmax 0.73 Minimum value of (A*B*C)/Pmax 0.00 If C>0, the minimum value of (A*B*C)/Pmax 0.06

Example 3: A chiral nanostructure comprising rod-shaped core-shell nanoparticles (1)

A rod-shaped core-shell nanoparticle having a core containing gold (Au) and a shell containing iron oxide (Fe ₃ O ₄ ) was prepared. The average length of the core is 2454 (± 624) nm, the average width of the core is 78 (± 16) nm, and the average thickness of the shell is 107 (± 12) nm. Non-chiral nanoparticle dispersions were prepared by dispersing the nanoparticles in a solvent of deionized water to have respective concentrations as shown in Table 3 below. Two neodymium (neodymium) magnets (50 x 10 x 2 mm, 0.2T) were prepared, and as shown in FIG. 5 , they were disposed to face each other at an interval of 3 cm in the same magnetization direction (y-axis direction). Each concentration of the achiral nanoparticle dispersion was placed in the center between the two magnets as shown in FIG. 7 . The two magnets were rotated by the same angular size using the y-axis as the rotation axis, one magnet was rotated clockwise and the other magnet was rotated counterclockwise. The size of the angle between the long axis of each magnet and the z-axis, that is, the size of the rotation angle θ, was rotated as shown in Table 3 below. Thus, the chiral nanostructure of Example 3 was prepared.

Concentration (B)
[μg/mL] θ
[°] τ Relative Ratio (C)
(|sin2θ|)
[θ=degree] CD spectrum [mdeg] (A*B*C)/Pmax
(A=78/107) @ around 560nm @ around 830nm Pmax Example 3-1 25 0 0.00 -7.53815 9.50373 9.50373 0.00 Example 3-2 50 0 0.00 -11.5166 11.6856 11.6856 0.00 Example 3-3 75 0 0.00 -19.4045 13.333 19.4045 0.00 Example 3-4 100 0 0.00 -30.2261 13.0284 30.2261 0.00 Example 3-5 125 0 0.00 -27.3712 29.2251 29.2251 0.00 Example 3-6 150 0 0.00 -22.7016 38.9029 38.9029 0.00 Example 3-7 175 0 0.00 -19.079 34.1915 34.1915 0.00 Example 3-8 200 0 0.00 -26.3219 35.9554 35.9554 0.00 Example 3-9 25 15 0.50 -7.91551 7.68037 7.91551 1.15 Example 3-10 50 15 0.50 -15.8674 -6.02037 15.8674 1.15 Example 3-11 75 15 0.50 -27.9142 -19.1392 27.9142 0.98 Example 3-12 100 15 0.50 -39.4368 -32.1212 39.4368 0.93 Examples 3-13 125 15 0.50 -51.6815 -47.6679 51.6815 0.88 Example 3-14 150 15 0.50 -57.5326 -65.4931 65.4931 0.84 Example 3-15 175 15 0.50 -70.7813 -100.152 100.152 0.64 Examples 3-16 200 15 0.50 -65.7547 -115.026 115.026 0.63 Example 3-17 25 30 0.87 -9.4047 0.259422 9.4047 1.68 Example 3-18 50 30 0.87 -20.5545 -14.4674 20.5545 1.54 Example 3-19 75 30 0.87 -35.1782 -35.3682 35.3682 1.34 Example 3-20 100 30 0.87 -54.9278 -64.9022 64.9022 0.97 Example 3-21 125 30 0.87 -70.683 -103.213 103.213 0.77 Example 3-22 150 30 0.87 -80.7226 -139.911 139.911 0.68 Example 3-23 175 30 0.87 -84.4237 -184.024 184.024 0.60 Example 3-24 200 30 0.87 -105.777 -236.778 236.778 0.53 Example 3-25 25 45 1.00 -8.93725 1.29636 8.93725 2.04 Example 3-26 50 45 1.00 -23.0299 -13.2333 23.0299 1.58 Example 3-27 75 45 1.00 -37.3763 -40.461 40.461 1.35 Example 3-28 100 45 1.00 -59.3599 -80.2965 80.2965 0.91 Example 3-29 125 45 1.00 -74.4613 -114.102 114.102 0.80 Examples 3-30 150 45 1.00 -93.3701 -167.345 167.345 0.65 Example 3-31 175 45 1.00 -93.1886 -216.908 216.908 0.59 Example 3-32 200 45 1.00 -109.779 -263.285 263.285 0.55 Example 3-33 25 60 0.87 -6.4495 2.78366 6.4495 2.45 Example 3-34 50 60 0.87 -14.6077 -12.3136 14.6077 2.16 Example 3-35 75 60 0.87 -29.8128 -33.7258 33.7258 1.41 Example 3-36 100 60 0.87 -49.5093 -60.2401 60.2401 1.05 Example 3-37 125 60 0.87 -63.1746 -96.4258 96.4258 0.82 Example 3-38 150 60 0.87 -82.6834 -146.269 146.269 0.65 Example 3-39 175 60 0.87 -76.156 -176.352 176.352 0.63 Examples 3-40 200 60 0.87 -74.7141 -206.697 206.697 0.61 Example 3-41 25 75 0.50 -6.55073 5.32714 6.55073 1.39 Example 3-42 50 75 0.50 -18.8469 -5.32564 18.8469 0.97 Example 3-43 75 75 0.50 -21.2838 -15.4706 21.2838 1.29 Example 3-44 100 75 0.50 -33.7699 -28.8007 33.7699 1.08 Example 3-45 125 75 0.50 -36.9541 -46.3082 46.3082 0.99 Example 3-46 150 75 0.50 -48.4698 -71.9071 71.9071 0.76 Example 3-47 175 75 0.50 -54.8074 -93.9875 93.9875 0.68 Example 3-48 200 75 0.50 -60.9551 -114.5 114.5 0.64 Example 3-49 25 90 0.00 -8.21705 5.6958 8.21705 0.00 Examples 3-50 50 90 0.00 -14.5284 4.16412 14.5284 0.00 Example 3-51 75 90 0.00 -19.2898 4.08091 19.2898 0.00 Example 3-52 100 90 0.00 -18.027 12.6545 18.027 0.00 Example 3-53 125 90 0.00 -21.2254 24.8205 24.8205 0.00 Example 3-54 150 90 0.00 -15.3822 22.9 22.9 0.00 Examples 3-55 175 90 0.00 -24.9115 20.5429 24.9115 0.00 Example 3-56 200 90 0.00 -23.7274 23.832 23.832 0.00 Example 3-57 25 105 0.50 -2.01906 8.26742 8.26742 1.10 Example 3-58 50 105 0.50 -4.33768 14.8651 14.8651 1.23 Example 3-59 75 105 0.50 -9.37984 28.0946 28.0946 0.97 Examples 3-60 100 105 0.50 -10.9829 52.7525 52.7525 0.69 Example 3-61 125 105 0.50 -5.55637 77.838 77.838 0.59 Example 3-62 150 105 0.50 2.34774 108.448 108.448 0.50 Example 3-63 175 105 0.50 -3.44082 129.594 129.594 0.49 Example 3-64 200 105 0.50 -1.00455 149.064 149.064 0.49 Example 3-65 25 120 0.87 -6.74832 8.49235 8.49235 1.86 Example 3-66 50 120 0.87 -3.26899 19.614 19.614 1.61 Example 3-67 75 120 0.87 -1.63751 42.1399 42.1399 1.13 Example 3-68 100 120 0.87 8.42136 87.5046 87.5046 0.72 Example 3-69 125 120 0.87 17.7691 125.622 125.622 0.63 Example 3-70 150 120 0.87 29.9982 180.58 180.58 0.53 Example 3-71 175 120 0.87 18.6498 204.748 204.748 0.54 Example 3-72 200 120 0.87 42.3768 244.464 244.464 0.52 Example 3-73 25 135 1.00 -4.69228 8.02431 8.02431 2.27 Example 3-74 50 135 1.00 -7.01615 15.3894 15.3894 2.37 Example 3-75 75 135 1.00 1.10383 51.6208 51.6208 1.06 Example 3-76 100 135 1.00 9.99771 90.5506 90.5506 0.81 Example 3-77 125 135 1.00 19.9972 135.318 135.318 0.67 Example 3-78 150 135 1.00 26.0874 195.643 195.643 0.56 Example 3-79 175 135 1.00 39.5219 234.553 234.553 0.54 Example 3-80 200 135 1.00 38.8694 293.858 293.858 0.50 Example 3-81 25 150 0.87 -6.71394 6.86092 6.86092 2.30 Example 3-82 50 150 0.87 -4.00949 12.8799 12.8799 2.45 Example 3-83 75 150 0.87 -2.05087 42.0491 42.0491 1.13 Example 3-84 100 150 0.87 2.5425 78.2846 78.2846 0.81 Example 3-85 125 150 0.87 17.0064 134.022 134.022 0.59 Example 3-86 150 150 0.87 15.4648 176.807 176.807 0.54 Example 3-87 175 150 0.87 39.1618 211.53 211.53 0.50 Example 3-88 200 150 0.87 35.0033 270.308 270.308 0.47 Example 3-89 25 165 0.50 -2.72344 3.83548 3.83548 2.38 Example 3-90 50 165 0.50 -6.24092 6.95336 6.95336 2.62 Example 3-91 75 165 0.50 -0.576269 24.7738 24.7738 1.10 Example 3-92 100 165 0.50 -6.19691 59.9633 59.9633 0.61 Example 3-93 125 165 0.50 2.06396 91.3203 91.3203 0.50 Example 3-94 150 165 0.50 9.68981 99.0606 99.0606 0.55 Example 3-95 175 165 0.50 7.16727 136.52 136.52 0.47 Example 3-96 200 165 0.50 8.96223 157.629 157.629 0.46 Maximum value of (A*B*C)/Pmax 2.62 Minimum value of (A*B*C)/Pmax 0.00 If C>0, the minimum value of (A*B*C)/Pmax 0.46

Example 4: Chiral structure comprising spherical half-shell nanoparticles

A spherical half-shell nanoparticle having a core including iron oxide (Fe ₃ O ₄ ) and a shell including gold (Au) and a half-shell including a half-shell was prepared. . The average diameter of the core is 204.6 (± 23.6) nm, and the average thickness of the shell is 22.8 (± 1.8) nm. Non-chiral nanoparticle dispersions were prepared by dispersing the nanoparticles in a solvent of deionized water so as to have respective concentrations as shown in Table 4 below. Two neodymium (neodymium) magnets (50 x 10 x 2 mm, 0.2T) were prepared, and as shown in FIG. 5 , they were disposed to face each other at an interval of 3 cm in the same magnetization direction (y-axis direction). Each concentration of the achiral nanoparticle dispersion was placed in the center between the two magnets as shown in FIG. 7 . The two magnets were rotated by the same angular size using the y-axis as the rotation axis, one magnet was rotated clockwise and the other magnet was rotated counterclockwise. The size of the angle between the long axis of each magnet and the z-axis, that is, the size of the rotation angle θ, was rotated as shown in Table 4 below. Thus, the chiral nanostructure of Example 4 was prepared.

Concentration (B)
[μg/mL] θ
[°] τ Relative Ratio (C)
(|sin2θ|)
[θ=degree] CD spectrum [mdeg] (A*B*C)/Pmax
(A=204.6/22.8) @ around 450nm @ around 700nm Pmax Example 4-1 25 0 0.00 -13.7293 -9.37537 13.7293 0.00 Example 4-2 50 0 0.00 -26.8003 -19.6424 26.8003 0.00 Example 4-3 75 0 0.00 -40.3599 -27.4027 40.3599 0.00 Example 4-4 100 0 0.00 -61.3673 -49.9827 61.3673 0.00 Example 4-5 125 0 0.00 -64.7302 -63.3074 64.7302 0.00 Example 4-6 150 0 0.00 -82.6592 -71.9333 82.6592 0.00 Example 4-7 175 0 0.00 -78.9345 -97.0621 97.0621 0.00 Examples 4-8 200 0 0.00 -82.7787 -80.4553 82.7787 0.00 Examples 4-9 25 15 0.50 -11.437 -6.12388 11.437 9.80 Example 4-10 50 15 0.50 -0.387778 -28.7961 28.7961 7.79 Examples 4-11 75 15 0.50 8.87803 -38.657 38.657 8.70 Example 4-12 100 15 0.50 14.8943 -64.7364 64.7364 6.93 Examples 4-13 125 15 0.50 27.2106 -113.701 113.701 4.93 Examples 4-14 150 15 0.50 32.7927 -126.945 126.945 5.30 Examples 4-15 175 15 0.50 41.7736 -163.453 163.453 4.80 Examples 4-16 200 15 0.50 81.4048 -197.244 197.244 4.55 Example 4-17 25 30 0.87 -11.437 -6.12388 11.437 16.98 Examples 4-18 50 30 0.87 9.05278 -30.7624 30.7624 12.63 Examples 4-19 75 30 0.87 39.1174 -56.1303 56.1303 10.38 Examples 4-20 100 30 0.87 79.4493 -82.8562 82.8562 9.38 Example 4-21 125 30 0.87 97.5773 -137.605 137.605 7.06 Example 4-22 150 30 0.87 129.521 -176.785 176.785 6.59 Example 4-23 175 30 0.87 173.356 -212.988 212.988 6.38 Example 4-24 200 30 0.87 179.851 -248.184 244.184 6.26 Examples 4-25 25 45 1.00 -3.60336 -13.2538 13.2538 16.92 Example 4-26 50 45 1.00 20.658 -37.4083 37.4083 11.99 Example 4-27 75 45 1.00 50.3629 -60.2882 60.2882 11.16 Example 4-28 100 45 1.00 88.9416 -95.797 95.797 9.36 Example 4-29 125 45 1.00 127.573 -159.375 159.375 7.04 Examples 4-30 150 45 1.00 148.764 -202.892 202.892 6.63 Example 4-31 175 45 1.00 164.48 -244.317 244.317 6.43 Example 4-32 200 45 1.00 177.76 -275.326 275.326 6.52 Example 4-33 25 60 0.87 -8.39113 -13.7004 13.7004 14.18 Example 4-34 50 60 0.87 12.5795 -38.8445 38.8445 10.00 Example 4-35 75 60 0.87 46.6445 -54.6695 54.6695 10.66 Example 4-36 100 60 0.87 78.3133 -98.3385 98.3385 7.90 Example 4-37 125 60 0.87 100.229 -136.854 136.854 7.10 Example 4-38 150 60 0.87 136 -196.026 196.026 5.94 Example 4-39 175 60 0.87 152.98 -239.44 239.44 5.68 Examples 4-40 200 60 0.87 174.774 -258.659 258.659 6.01 Example 4-41 25 75 0.50 -13.1136 -11.9487 13.1136 8.55 Example 4-42 50 75 0.50 -2.90439 -25.3031 25.3031 8.86 Example 4-43 75 75 0.50 14.0841 -46.955 46.955 7.16 Example 4-44 100 75 0.50 25.5531 -65.2249 65.2249 6.88 Example 4-45 125 75 0.50 32.7731 -110.369 110.369 5.08 Example 4-46 150 75 0.50 38.7656 -150.619 150.619 4.47 Example 4-47 175 75 0.50 68.8032 -167.151 167.151 4.70 Example 4-48 200 75 0.50 80.1045 -181.408 181.408 4.94 Example 4-49 25 90 0.00 -13.6779 -11.4838 13.6779 0.00 Examples 4-50 50 90 0.00 -31.6212 -20.6161 31.6212 0.00 Example 4-51 75 90 0.00 -41.8544 -23.6395 41.8544 0.00 Example 4-52 100 90 0.00 -41.9537 -31.529 41.9537 0.00 Example 4-53 125 90 0.00 -89.1371 -56.5824 89.1371 0.00 Example 4-54 150 90 0.00 -74.274 -77.7345 77.7345 0.00 Example 4-55 175 90 0.00 -133.742 -62.0819 133.742 0.00 Example 4-56 200 90 0.00 -87.9446 -50.7764 87.9446 0.00 Example 4-57 25 105 0.50 -24.9615 -2.0642 24.9615 4.49 Example 4-58 50 105 0.50 -53.6922 -7.2385 53.6922 4.18 Example 4-59 75 105 0.50 -81.738 -9.26416 81.738 4.12 Examples 4-60 100 105 0.50 -129.965 0.163201 129.965 3.45 Example 4-61 125 105 0.50 -191.557 5.12119 191.557 2.93 Example 4-62 150 105 0.50 -229.336 -11.7384 229.336 2.93 Example 4-63 175 105 0.50 -239.939 22.9567 239.939 3.27 Example 4-64 200 105 0.50 -241.141 52.4878 241.141 3.72 Example 4-65 25 120 0.87 -30.2692 -0.84840 30.2692 6.42 Example 4-66 50 120 0.87 -76.1418 -0.62602 76.1418 5.10 Example 4-67 75 120 0.87 -128.125 3.04504 128.125 4.55 Example 4-68 100 120 0.87 -163.733 16.9155 163.733 4.74 Example 4-69 125 120 0.87 -244.645 36.2708 244.645 3.97 Example 4-70 150 120 0.87 -328.532 47.1086 328.532 3.55 Example 4-71 175 120 0.87 -336.89 100.448 336.89 4.04 Example 4-72 200 120 0.87 -346.413 119.458 346.413 4.48 Example 4-73 25 135 1.00 -30.1818 -0.43374 30.1818 7.43 Example 4-74 50 135 1.00 -77.7811 0.402123 77.7811 5.77 Example 4-75 75 135 1.00 -138.074 6.51752 138.074 4.87 Example 4-76 100 135 1.00 -208.923 25.7691 208.923 4.29 Example 4-77 125 135 1.00 -276.945 39.2789 276.945 4.05 Example 4-78 150 135 1.00 -331.597 56.2207 331.597 4.06 Example 4-79 175 135 1.00 -351.074 127.933 351.074 4.47 Example 4-80 200 135 1.00 -466.984 168.866 466.984 3.84 Example 4-81 25 150 0.87 -28.4136 -2.24077 28.4136 6.83 Example 4-82 50 150 0.87 -76.1401 -0.08146 76.1401 5.10 Example 4-83 75 150 0.87 -117.67 2.83803 117.67 4.95 Example 4-84 100 150 0.87 -179.737 12.7147 179.737 4.32 Example 4-85 125 150 0.87 -233.904 31.5423 223.904 4.15 Example 4-86 150 150 0.87 -311.735 39.6801 311.735 3.74 Example 4-87 175 150 0.87 -323.65 94.0516 323.65 4.20 Example 4-88 200 150 0.87 -326.197 120.249 326.197 4.76 Example 4-89 25 165 0.50 -25.1369 -5.97778 25.1369 4.46 Example 4-90 50 165 0.50 -54.1712 -8.91204 54.1712 4.14 Example 4-91 75 165 0.50 -85.2771 -16.5045 85.2771 3.94 Example 4-92 100 165 0.50 -112.405 -7.10573 112.405 3.99 Example 4-93 125 165 0.50 -172.165 -9.25674 172.165 3.26 Example 4-94 150 165 0.50 -204.38 -15.8375 204.38 3.29 Example 4-95 175 165 0.50 -226.903 14.977 226.903 3.46 Example 4-96 200 165 0.50 -262.556 26.2862 262.556 3.42 Maximum value of (A*B*C)/Pmax 16.98 Minimum value of (A*B*C)/Pmax 0.00 Minimum value of (A*B*C)/Pmax when C>0 2.93

<Example of measurement>

Measurement Example 1: Circular Dichroism Spectroscopy (CD)

For each chiral nanostructure prepared in Examples 1 to 4, a scan rate of 500 nm/min, a data interval of 0.5 nm, and 200 nm to 900 nm using a circular dichroism spectrometer (JASCO, J-1500) Spectra were obtained under the condition of a wavelength range of

Spectra of the chiral nanostructures of Examples 1 to 4 are as shown in FIGS. 8 to 11, respectively. 8 to 11 , it can be seen that the chiral nanostructures of Examples 1 to 4 each exhibit two peaks on the CD spectrum. These two peaks are derived from the core and the shell of the nanoparticles, respectively. The shape and concentration of the nanoparticles, the components of the core and the shell, the rotation angle of the magnetic material for imparting chirality, etc. can all affect the shape of the spectrum comprehensively. The wavelength range and peak value of each peak are described in Tables 1 to 4.

Measurement Example 2: Chirality of the magnetic field (τ)

In Examples 1 to 4, the relative ratio of the magnitude (°) of the rotation angle (θ) of the two magnets and the chirality (τ) of the helical magnetic field generated by the rotation of the two magnets is sin( 2θ) was calculated and described in Tables 1 to 4, respectively.

Measurement example 3

In the spectrum of Measurement Example 1, the absolute value (P _max ) of the peak value of the peak having the maximum size among the two peaks is described in Tables 1 to 4, and using this, ( A * B * C)/P _max values were respectively obtained and described in Tables 1 to 4 above.

Referring to the Measurement Examples 1 to 3, it was confirmed that the chiral nanostructures of Examples 1 to 4 satisfy the (A * B * C)/P _max value of Equation 1 from 0 to 20. , through this, it was confirmed that the chirality corresponding to each helical magnetic field generated according to the rotation angle of the magnetic material was immediately and quickly displayed.

More specifically, in the chiral nanostructures of Examples 1 and 2, the nanoparticles thereof include spherical core-shell particles, and in the core-shell particles, the shell substantially surrounds the surface of the core. is the structure, and it was confirmed that the value of (A * B * C)/P _max in Equation 1 satisfies about 0.01 to about 1.0.

In addition, in the chiral nanostructure of Example 3, the nanoparticles include rod-shaped core-shell particles, and the value of (A * B * C)/P _max in Equation 1 is about 0.3 to It was confirmed that about 3.0 was satisfied.

In addition, in the chiral nanostructure of Example 4, the nanoparticles include spherical core-shell particles, and in the core-shell particles, the shell partially surrounds the surface of the core. -shell) structure, and it was confirmed that the value of (A * B * C)/P _max in Formula 1 satisfies about 0.01 to about 20.

As such, it can be confirmed that the chiral nanostructure has chirality derived by the structural characteristics of the nanoparticle array structure, and that the chirality is imparted and modulated in real time by a relatively simple technical means of applying a spiral magnetic field. there was. Such structural chirality and real-time self-assembly of the chiral nanostructure may have the advantage of securing wide applicability in a technical field to which the chiral nanostructure can be applied.

200: chiral nanostructure
22: nanoparticles
210: nano particle array structure
201: first structure
202: second structure
14: core
15: shell
11: magnetic body
12: magnetic material
13: spiral magnetic field
L1, L2: long axis of magnetic material
21: colloidal solution

Claims (7)

Containing two or more nanoparticle array structures,
The nanoparticle array structure may include: a first structure including at least one nanoparticle; and a second structure including at least one nanoparticle and spaced apart from the first structure,
The entire structure is a chiral nanostructure with chirality,
The chirality is variable by applying a helical magnetic field,
The nanoparticles include magnetic plasmon particles,
The magnetic plasmon particle is a core (core); and a core-shell particle surrounding at least a part of the core and having a shell including a component different from the component of the core,
In the core-shell particle, one of the core and the shell includes a magnetic component, and the other includes a metal component,
The value of the following formula 1 of the chiral nanostructure is 0 to 20,
Chiral nanostructures:
[Equation 1]

In Equation 1, A is the ratio of the core average particle diameter (nm) to the average shell thickness (nm) when the nanoparticles are spherical core-shell particles; or a ratio of the average core width (nm) to the average shell thickness (nm) when the nanoparticles are rod-shaped core-shell particles,
B is the concentration (μg/mL) value of the nanoparticles in the solution when the chiral nanostructure is in a colloidal solution state in a solvent or dispersion medium, and is any one of 25 to 200,
C is the ratio of relative chirality magnitudes when the magnitude value of chirality (τ) is 1.0 when the rotation angle θ of the helical magnetic field applied to the chiral nanostructure is 45°, and 0 to Any value of 1.0,
The Pmax is an absolute value of the maximum peak value when a circular dichroism spectroscopy of the chiral nanostructure is measured. delete According to claim 1,
The time (T2-T1) from the application time (T1) of the helical magnetic field to the time (T2) when the change is completed to exhibit chirality corresponding to the applied helical magnetic field is 0.01 ms to 20 ms,
Chiral nanostructures. According to claim 1,
The spaced straight distance between the first structure and the second structure is 0.01 nm to 50 μm,
Chiral nanostructures. According to claim 1,
The magnetic plasmon particles include spherical core-shell particles,
The shell is a structure surrounding the entire surface of the core,
The value of Formula 1 is 0 to 3.0,
Chiral nanostructures. According to claim 1,
The magnetic plasmon particles include spherical core-shell particles,
The shell is a structure surrounding a part of the surface of the core,
The value of Formula 1 is 0 to 19.00,
Chiral nanostructures. According to claim 1,
The magnetic plasmon particles include rod-shaped core-shell particles,
The shell is a structure surrounding the entire surface of the core,
The value of Formula 1 is 0 to 3.0,
Chiral nanostructures.

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