KR102350766B1 - Spiral magnetic field forming device for imparting chirality - Google Patents

Abstract

The present invention relates to a method of manufacturing a spiral magnetic field forming device for imparting hand symmetry. A spiral magnetic field forming apparatus for imparting hand symmetry according to the present invention comprises: a first magnetic body forming a magnetic field; a second magnetic body spaced apart from the first magnetic body part by a predetermined distance; and a receptor part positioned between the first magnetic body part and the second magnetic body part to receive the nanoparticles; based on an imaginary center line passing through the first magnetic body part and the second magnetic body part at the same time, the The first magnetic body part and the second magnetic body part may rotate in opposite directions to each other.

Description

Spiral magnetic field forming device for giving hand symmetry

The present invention relates to a spiral magnetic field forming device for imparting hand symmetry. More specifically, the present invention is to provide an apparatus for forming a spiral magnetic field for imparting hand symmetry capable of effectively manufacturing a chiral nanostructure by a simpler process.

All substances in nature have hand symmetry, that is, chirality. In particular, in the case of amino acids, most of them consist of L-amino acid, and in the case of saccharides, D-sugar is the mainstay. As such, biological organisms always have one side of chirality (homochirality), so when they react with a filtering material, fatal damage to the organism appears.

With the development of synthesis technology, it has become easier to manufacture metals at the level of nanoparticles, and it has been revealed that various metal nanoparticles have various and unique optical properties due to the advancement of analysis technology. It has been found that the optical properties of metal nanostructures change depending on the geometrical structure, which is due to the localized surface plasmon resonance (LSPR) phenomenon. In addition, as it has recently developed into a new next-generation industrial field in the field of nanoscience, nanomaterials are being applied in various fields. According to these scientific and technological currents, research on synthesizing chiral nanostructures by imparting chirality properties to nanomaterials has recently been attracting attention.

A chiral structure means a structure having an asymmetric structure that does not have any mirror image symmetry. In the chiral structure, the degeneracy of right and left polarization is broken because electric dipoles and magnetic dipoles generated by incident electromagnetic waves interact in the same direction. Accordingly, the chiral structure has different refractive indices with respect to the left polarized light and the right polarized light. Accordingly, when linearly polarized light is incident on the chiral material, a photoactive characteristic in which the polarization state is rotated appears. The chiral structure can be variously used in optical materials and catalyst fields by using such photoactive properties.

A chiral structure for these nanoparticles is often prepared by chemical synthesis. Also, recently, a method for synthesizing using a peptide to which two or more amino acids are bound has been proposed. A method using e-beam lithography, which can precisely control the shape of a nanostructure, and a hole lithography method using nano-sized holes for rotational deposition are being studied.

Accordingly, the present inventors have researched a method for producing a chiral nanostructure in a more sophisticated manner with a simpler process, and have completed the present invention.

KR 10-2019-0117370 A KR 10-1581406 B1

SUMMARY OF THE INVENTION It is an object of the present invention to provide an apparatus capable of manufacturing a chiral nanostructure exhibiting nano-size precision.

An object of the present invention is to make it possible to manufacture a chiral nanostructure with improved precision and process easiness by using the device.

It is an object of the present invention to provide the advantage of being able to manufacture a large amount of chiral nanostructures through a method of manufacturing a chiral nanostructure with a simpler process and higher precision compared to the conventional method using the device, and can be used in more diverse fields. This is to enable the chiral nanostructure to be utilized.

An object of the present invention is to ensure immediate real-time performance not only when chirality is first given, but also when additional chirality is modulated as needed.

In order to achieve the above object, a helical magnetic field forming apparatus for imparting hand symmetry according to an embodiment of the present invention includes a first magnetic body forming a magnetic field; a second magnetic body spaced apart from the first magnetic body part by a predetermined distance; and a receptor part positioned between the first magnetic body part and the second magnetic body part to receive the nanoparticles; based on an imaginary center line passing through the first magnetic body part and the second magnetic body part at the same time, the The first magnetic body part and the second magnetic body part may rotate in opposite directions to each other.

The first magnetic body part and the second magnetic body part may have a panel shape having a predetermined thickness.

The first magnetic body part and the second magnetic body part may rotate at the same speed.

The nanoparticles may include magnetic plasmonic particles.

The magnetic plasmon particles, a core (core); and a core-shell particle surrounding at least a portion of the surface of the core and having a shell including a component different from the component of the core.

In the core-shell particle, one of the core and the shell may include a magnetic component, and the other may include a metal component.

The nanoparticles may be accommodated in the receptor in a state in which one selected from the group consisting of distilled water, deionized water, alcohol, an organic solvent, a polymer, and a combination thereof is dispersed in a solvent.

The spiral magnetic field forming apparatus for imparting the hand symmetry may be one in which a spiral magnetic field is formed between the first magnetic body part and the second magnetic body part.

The spiral magnetic field forming device for imparting the hand symmetry adjusts the distance between the first magnetic body part and the second magnetic body part so that the spatial range of the magnetic field generated through the first magnetic body part and the second magnetic body part is adjusted. may be doing

The spiral magnetic field forming apparatus for imparting the hand symmetry adjusts the magnetic force of the first magnetic body part and the second magnetic body part or the distance between the first magnetic body part and the second magnetic body part to adjust the first magnetic body part and the second magnetic body part The magnetic flux density of the magnetic field generated through the magnetic body may be controlled.

The chiral nanostructure according to another embodiment of the present invention may be manufactured with a helical magnetic field forming device for imparting hand symmetry.

Hereinafter, the present invention will be described in more detail.

A spiral magnetic field forming apparatus for imparting hand symmetry according to an embodiment of the present invention includes: a first magnetic body forming a magnetic field; a second magnetic body spaced apart from the first magnetic body part by a predetermined distance; and a receptor part positioned between the first magnetic body part and the second magnetic body part to receive the nanoparticles; based on an imaginary center line passing through the first magnetic body part and the second magnetic body part at the same time, the The first magnetic body part and the second magnetic body part may rotate in opposite directions to each other.

It is defined that the means for rotating the first magnetic body part and the second magnetic body includes all means that can be used by a person skilled in the art. On the other hand, it may be more advantageous for the rotating means to give or control the chirality of the nanoparticles that the speed can be controlled.

In the case of the spiral magnetic field forming apparatus for imparting hand symmetry, it provides the advantage of being able to manufacture a large amount of chiral nanostructures by a relatively simple method through magnetic field application and control means, and utilizes chemical synthesis methods or Compared to a conventional manufacturing method such as using a separate template, process easiness and efficiency are improved, and further, precision is improved. In addition, it has the advantage of securing immediate real-time not only in the case of providing chirality for the first time, but also in the modulation of additional chirality as needed.

In the case of using the spiral magnetic field forming apparatus for imparting the hand symmetry, a three-dimensional nanostructure having chirality may be manufactured. Chirality refers to the asymmetric property. Structurally, the particulated structure having such chirality can be usefully applied to an optical technology field such as a liquid crystal display (LCD) or a bio field such as pharmaceuticals. The manufacturing method of the chiral nanostructure provides a means for manufacturing a particle structure having high purity chirality in a large amount, and in the case of a three-dimensional nanostructure manufactured through this, the optical device field in the pharmaceutical and bio field It can function as a material with great potential to pioneer new research fields. On the other hand, hand symmetry emitted in the present invention means chirality or chirality.

A plasmon is a similar particle in which free electrons in a metal vibrate collectively. In metal nanoparticles, plasmons exist locally on the surface, so they are also called surface plasmons. Among them, in metal nanoparticles, an electric field of light in the visible to near-infrared band is paired with a plasmon, light absorption occurs, and a vivid color is obtained.

It was confirmed that nanostructures having chirality can be manufactured by processing a magnetic field of a certain shape, more specifically, a helical magnetic field with respect to the plasmonic nanoparticles.

Preferably, the nanoparticles may have a uniform particle size. The nanoparticles may have a standard deviation of particle diameter of less than 20. If the magnetic field formed using the device according to the present invention to nanoparticles having a uniform particle diameter in the above range, specifically, a helical magnetic field, a chiral structure can be manufactured more easily.

Specifically, in the helical magnetic field forming device for imparting hand symmetry, the first magnetic body part and the second magnetic body part rotate with a predetermined distance apart to form a magnetic field having a predetermined magnetic flux density and magnetization direction within a predetermined spatial range. can be In particular, a spiral magnetic field may be formed between the first magnetic part and the second magnetic part by adjusting the rotation directions of the first magnetic part and the second magnetic part. When the magnetic field is a helical magnetic field, the magnetic field itself has structural chirality, and by transferring the chirality induced from the magnetic field to the nanoparticles applying it, it is easier to manufacture a nanostructure having chirality. can

1 illustrates the formation of a spiral magnetic field by rotating the first magnetic body part and the second magnetic body part according to an embodiment of the present invention. When the present invention is described in more detail with reference to FIG. 1, the two magnetic materials 11 and 12 are disposed to face each other in the same magnetization direction (y-axis direction) and then rotated relative to each other in opposite directions to form a helical magnetic field ( 13) can be formed. In the magnetic field shaping step according to an embodiment, the two magnetic materials 11 and 12 have an axis (y-axis) passing through each center at the same time as a rotation axis, so that one magnetic material 11 is clockwise, the other magnetic material (12) can be rotated relative to the counterclockwise direction. One magnetic body 11 rotates clockwise so that the angle θ1 between its long axis L1 and the z-axis is in the range of 0° < θ1 < 180°, and the other magnetic body 12 has its long axis L2 It can be rotated counterclockwise so that the angle θ2 between the and z-axis is in the range of 0°>θ2>-180°.

For example, the two magnetic materials 11 and 12 may be rotated so that the absolute values of θ1 and θ2 have the same magnitude. The structure of the spiral magnetic field 13 may be determined by adjusting the magnitudes of θ1 and θ2 . The spiral magnetic field 13 exhibits chirality by having a mirror surface asymmetric structure, and the degree of chirality may be adjusted according to the sizes of θ1 and θ2 . When the magnitudes of the absolute values of θ1 and θ2 are referred to as θ, the magnitude of the chirality of the spiral magnetic field may be proportional to the magnitude of sin(2θ).

In one embodiment, the magnetic material may include a neodymium magnet. Specifically, the magnetic flux density of the neodymium magnet may be from about 1 μT to about 5T, for example, from about 0.01T to about 0.4T, for example, from about 0.01T to about 0.3T.

In one embodiment, the separation distance defined as a straight line distance connecting the centers of the two magnetic materials may be about 1 μm to about 10 m, for example, about 1 μm to about 5 m, for example, about 1 μm to about 1 m, for example, 1 μm to about 80 cm, for example, about 1 cm to about 50 cm, for example, about 1 cm to about 10 cm, for example , may be from about 1 cm to about 8 cm, for example, from about 1 cm to about 6 cm, for example, from about 1 cm to about 5 cm, for example, from about 1 cm to about 4 cm.

2 is for explaining the arrangement of nanoparticles in the receiving unit according to an embodiment of the present invention.

It may be disposed in a receiving portion between the first magnetic body part and the second magnetic body part before the magnetic field is formed or after the magnetic field is formed. The nanoparticles disposed in the receiving part may be formed into a particle structure having chirality under the influence of the helical magnetic field. In addition, by controlling the formed magnetic field, it is possible to generate or control the chirality of the nanoparticles. Through this, it is possible to mass-produce three-dimensional nanostructures with more precise chirality.

The first magnetic body part and the second magnetic body part facing with respect to the receptor part may have a panel shape having a predetermined thickness. In the case of using the magnetic body part having a panel shape, it may be advantageous to form a magnetic field of a sophisticated helical structure capable of generating nanoparticles having chirality. In addition, the thickness of the first magnetic body portion and the second magnetic body may be the same and have the same magnetic force. Through this, as will be described later, a magnetic field formed by adjusting a distance or a magnetic force spaced apart between the first magnetic body part and the second magnetic body can be more effectively controlled. This has the advantage of being able to precisely control the chirality of nanoparticles.

The first magnetic body part and the second magnetic body part may rotate at the same speed.

The nanoparticles may include magnetic plasmonic particles.

Plasmon refers to a phenomenon in which free electrons inside a metal vibrate collectively. In the case of metal nanoparticles, plasmons may exist locally on the surface, which may be referred to as surface plasmons. When the metal nanoparticles meet the electric field of light in the range from visible light to near-infrared light, light absorption occurs by surface plasmon resonance (SPR) to give a vivid color. The magnetic plasmon particles are plasmonic particles having magnetism, and may be arranged in a predetermined arrangement in a magnetic field by magnetism, and may be colored by a plasmon phenomenon.

The magnetic plasmon particles, a core (core); and a core-shell particle surrounding at least a portion of the surface of the core and having a shell including a component different from the component of the core.

In the core-shell particle, one of the core and the shell may include a magnetic component, and the other may include a metal component. a core including a magnetic component and a shell including a metal component; Alternatively, through a combination of a shell including a magnetic component and a core including a metal component, it may be advantageous for the nanostructures to be aligned in a predetermined arrangement in a magnetic field while realizing a desired color to form a precise chiral structure.

The metal component is, for example, silver (Ag), gold (Au), platinum (Pt), copper (Cu), palladium (Pd), nickel (Ni), cobalt (Co), iron (Fe), manganese It may include one selected from the group consisting of (Mn), chromium (Cr), vanadium (V), titanium (Ti), aluminum (Al), zinc (Zn), cadmium (Cd), and combinations thereof.

The magnetic component is, for example, iron oxide (Fe ₃ O ₄ ), nickel oxide (NiO), cobalt oxide (Co ₃ O ₄ ), iron (Fe), nickel (Ni), cobalt (Co), and combinations thereof It may include one selected from the group consisting of.

In one embodiment, the core is silver (Ag), gold (Au), platinum (Pt), copper (Cu), palladium (Pd), nickel (Ni), cobalt (Co), iron (Fe) , manganese (Mn), chromium (Cr), vanadium (V), titanium (Ti), aluminum (Al), zinc (Zn), including one selected from the group consisting of cadmium (Cd) and combinations thereof, The shell is selected from the _{group consisting of iron oxide (Fe 3} O ₄ ), nickel oxide (NiO), cobalt oxide (Co ₃ O ₄ ), iron (Fe), nickel (Ni), cobalt (Co), and combinations thereof. It may include a selected one.

In another embodiment, the core is iron oxide (Fe ₃ O ₄ ), nickel oxide (NiO), cobalt oxide (Co ₃ O ₄ ), iron (Fe), nickel (Ni), cobalt (Co) and these including one selected from the group consisting of a combination of silver (Ag), gold (Au), platinum (Pt), copper (Cu), palladium (Pd), nickel (Ni), cobalt ( Co), iron (Fe), manganese (Mn), chromium (Cr), vanadium (V), titanium (Ti), aluminum (Al), zinc (Zn), cadmium (Cd) and combinations thereof It may include a selected one.

Through such a core-shell structure, the nanostructure can realize excellent color expression and optical properties, and there is an advantage that it is easy to control the nanoparticles to be aligned in a desired arrangement in a magnetic field, and for fine control of the magnetic field The arrangement can be changed in real time, which can be advantageous for chirality control.

3 schematically shows a cross-section of various types of nanoparticles capable of imparting chirality through an embodiment of the present invention. Referring to FIGS. 3A and 3B , the nanoparticles may be spherical core-shell particles, and referring to FIG. 3C , the nanoparticles are rod-shaped core-shell particles. can be Specifically, the spherical core-shell particle may have a structure including the core 14 and the shell 15 surrounding substantially the entire surface thereof, as shown in FIG. As shown in (b), it may be a half-shell structure including the core 14 and the shell 15 surrounding a part of the surface thereof. The meaning of 'half-shell' in this specification does not mean only when the shell 15 surrounds exactly half of the surface area of the core 14, but surrounds at least a part instead of the whole. All are understood to be generic. The rod-shaped core-shell particle may have a structure including the core 14 and the shell 15 surrounding the entire surface thereof, as shown in FIG. 3C , and the core 14 and its It may be a structure (not shown) including a shell 15 surrounding a portion of the surface.

In one embodiment, the nanoparticles include spherical core-shell particles or rod-shaped core-shell particles, and the spherical core-shell particles or the rod-shaped core-shell particles include a core; and a shell surrounding the entire surface of the core and including a component different from the component of the core, wherein the core includes silver (Ag), gold (Au), platinum (Pt), copper (Cu), palladium ( Pd), nickel (Ni), cobalt (Co), iron (Fe), manganese (Mn), chromium (Cr), vanadium (V), titanium (Ti), aluminum (Al), zinc (Zn), cadmium ( Cd) and one selected from the group consisting of combinations thereof, wherein the shell is iron oxide (Fe ₃ O ₄ ), nickel oxide (NiO), cobalt oxide (Co ₃ O ₄ ), iron (Fe), It may include one selected from the group consisting of nickel (Ni), cobalt (Co), and combinations thereof.

For example, the core may include silver (Ag), gold (Au), or a combination thereof, and the shell may include iron oxide (Fe ₃ O ₄ ). Because the nanoparticles have a core-shell structure including a combination of these components, the desired chirality can be precisely given by controlling the magnetic field, and the chirality can be adjusted immediately by the change of the magnetic field. The effect can be maximized.

In another embodiment, the nanoparticles include spherical core-shell particles or rod-shaped core-shell particles, and the spherical core-shell particles or the rod-shaped core-shell particles include a core; and a half-shell surrounding a part of the core and including a component different from the component of the core, wherein the core is iron oxide (Fe ₃ O ₄ ), nickel oxide (NiO), Cobalt oxide (Co ₃ O ₄ ), iron (Fe), nickel (Ni), including one selected from the group consisting of cobalt (Co) and combinations thereof, the shell (shell) is silver (Ag), gold ( Au), platinum (Pt), copper (Cu), palladium (Pd), nickel (Ni), cobalt (Co), iron (Fe), manganese (Mn), chromium (Cr), vanadium (V), titanium ( Ti), aluminum (Al), zinc (Zn), cadmium (Cd), and may include one selected from the group consisting of combinations thereof.

For example, the core may include iron oxide (Fe ₃ O ₄ ), and the shell may include silver (Ag), gold (Au), or a combination thereof. Because the nanoparticles have a core-shell structure including a combination of these components, the desired chirality can be precisely given by controlling the magnetic field, and the chirality can be adjusted immediately by the change of the magnetic field. The effect can be maximized.

4 shows a photograph of the spherical core-shell particle according to an embodiment, and FIG. 5 shows a photograph of the rod-shaped core-shell particle according to an embodiment.

In one embodiment, the spherical core-shell particle has an average particle diameter of the core 14 of about 0.01 nm to about 300 nm, for example, about 5 nm to about 250 nm, for example, about 5 nm to about 100 nm, for example For example, it may be about 5 nm to about 90 nm, for example, about 5 nm to about 80 nm, for example, about 20 nm to about 80 nm, for example, about 40 nm to 80 nm.

The average thickness of the shell of the spherical core-shell particle is from about 1 nm to about 150 nm, such as from about 1 nm to about 120 nm, such as from about 1 nm to about 100 nm, such as from about 1 nm to about 80 nm, e.g. For example, from about 5 nm to about 80 nm, such as from about 10 nm to about 80 nm, such as from about 10 nm to about 70 nm, such as from about 20 nm to about 60 nm, such as from about 30 nm to about 60 nm, such as For example, it may be about 40 nm to about 60 nm.

In the spherical core-shell particle, the aspect ratio defined as the ratio (L/S) of the major axis (L) and the minor axis (S) of the core 14 based on the cross section is about 1.00 to about 2.00 , for example from about 1.00 to about 1.80, such as from about 1.00 to about 1.75, such as from about 1.00 to about 1.70, such as from about 1.00 to about 1.65, such as from about 1.00 to about 1.60 can be

The spherical core-shell particles may have a standard deviation of the particle diameter of the core 14 for a powder of 1 mg amount of about 30 nm or less, for example, about 25 nm or less, for example, about 20 nm to about 10 nm may be nm. The magnetic plasmon particles may be used as a powder, that is, an aggregate including a plurality of particles. In this case, the plurality of magnetic plasmon particles may be aligned to have a predetermined interval and a relative positional relationship with each other under a magnetic field application condition to form a desired three-dimensional structure. When the standard deviation range for the amount of powder satisfies the above range, the structural regularity and accuracy of the three-dimensional structure manufactured using the magnetic plasmon particles may be improved, and it may be more advantageous in terms of mass design.

In one embodiment, the rod-shaped core-shell particle has an average width of the core of about 0.01 nm to about 100 nm, for example, about 5 nm to about 100 nm, for example, about 5 nm to about 90 nm , for example, about 5 nm to about 80 nm, such as about 20 nm to about 80 nm, such as about 40 nm to 80 nm.

The average thickness of the shell of the rod-shaped core-shell particle is from about 1 nm to about 150 nm, such as from about 1 nm to about 120 nm, such as from about 1 nm to about 100 nm, such as from about 1 nm to about 80 nm. , for example from about 5 nm to about 80 nm, such as from about 10 nm to about 80 nm, such as from about 10 nm to about 70 nm, such as from about 20 nm to about 60 nm, such as from about 30 nm to about 60 nm , for example, from about 40 nm to about 60 nm.

In the rod-shaped core-shell particle, the aspect ratio defined as the ratio (L/W) of the length (L) and width (W) of the core is from about 5.00 to about 40.00, for example, about 10.00 to about 40.00, such as about 15.00 to about 35.00.

The rod-shaped core-shell particles may have a standard deviation of the width of the core 14 for a powder of 1 mg quantity of about 30 nm or less, for example, about 25 nm or less, for example, about 20 nm to about 20 nm or less. It may be 10 nm. The magnetic plasmon particles may be used as a powder, that is, an aggregate including a plurality of particles. In this case, the plurality of magnetic plasmon particles may be aligned to have a predetermined interval and a relative positional relationship with each other under a magnetic field application condition to form a desired three-dimensional structure. When the standard deviation range for the amount of powder satisfies the above range, the structural regularity and accuracy of the three-dimensional structure manufactured using the magnetic plasmon particles may be improved, and it may be more advantageous in terms of mass design.

In the structure of the spherical core-shell particle and the rod-shaped core-shell particle, the average particle diameter of the core, the average width of the core, the average thickness of the shell, the major and minor diameters of the core, and the length of the core and width are both two-dimensional values measured with respect to the cross section of the particle, and can be obtained from a projection image obtained through means such as a scanning electron microscope (SEM) or a transmission electron microscope (TEM). In the average particle diameter of the core, the average width of the core, and the average thickness of the shell, 'average' means 'number average'. In the spherical core-shell particle, the longest particle diameter of any one core means the major diameter of the core, and the shortest particle diameter means the minor diameter of the core. In the rod-shaped core-shell particle, the relatively longer length among the width and length of any one core is referred to as the length of the core, and the relatively short length is referred to as the width of the core. In the spherical and rod-shaped core-shell particles, the thickness of the shell means a vertical straight line distance from the interface between the core and the shell to the outer surface of the shell.

The magnetic field formed by the rotation of the first magnetic body part and the second magnetic body part is a spiral magnetic field, and the nanoparticles include magnetic plasmonic particles, and the magnetic plasmonic particles include a core; and a core-shell particle surrounding at least a part of the surface of the core and having a shell including a component different from the component of the core, wherein the chiral nanostructure is represented by Formula 1 A value of 0 to 20 may be satisfied.

[Equation 1]

In Equation 1, A is the ratio of the average core particle diameter (nm) to the shell average thickness (nm) of the nanoparticles; or the ratio of the average core width (nm) to the shell average thickness (nm), B is the concentration (㎍ / mL) value of the nanoparticles, and C is the rotation angle (θ) of the spiral magnetic field is 45 ° is the ratio of the relative chirality size when the size value of the chirality (τ) is 1.0, and the P _max is the circularly polarized light under the B and C conditions of the chiral nanostructure satisfying the A It is the absolute value of the maximum peak value of Circular Dichroism Spectroscopy.

In one embodiment, in the value of Equation 1, B may be any one of about 25 to about 200, and C may be any one of about 0 to about 1.0. When the value of Equation 1 derived from such concentration and angle conditions satisfies the range of about 0 to about 20, the value of Equation 1 and the real-time chiral variability and structural integrity of the chiral nanostructure will be greatly improved. can

The value of Formula 1 does not have to satisfy about 0 to about 20 in all the aforementioned ranges of B and C, but any one value of B and any one value of C in each of the aforementioned ranges. When a specific value within the range of about 0 to about 20 is satisfied, the chiral nanostructure may be an indicator indicating that the desired real-time variability and structural chiral integrity are secured. However, the real-time variability and structural chiral integrity are improved as the number of cases in which the range of the value of Equation 1 satisfies the corresponding range within the aforementioned ranges of B and C increases.

When the nanoparticles are spherical core-shell particles, A is a value of the ratio (D/T) of the average core particle diameter (D) to the average shell thickness (T). When the nanoparticles are rod-shaped core-shell particles, A is a value of the ratio (W/T) of the average core width (W) to the average shell thickness (T).

B is the concentration (μg/mL) value of nanoparticles in the chiral nanostructure.

As described below, the nanoparticles accommodated in the receptor may be disposed in a state of a colloidal solution dispersed in a solvent. In this case, B is the concentration (μg/mL) value of the nanoparticles in the colloidal solution. Specifically, in the case of manufacturing a chiral nanostructure from a non-chiral nanoparticle dispersion through the manufacturing method of the chiral nanostructure; and changing the chirality of one chiral nanostructure to prepare another chiral nanostructure; All of the above B may be defined as the concentration (μg/mL) value of the nanoparticles in the solution.

C is the ratio of relative chirality magnitudes when the magnitude value of chirality (τ) is 1.0 when the rotation angle (θ) of the long helical field applied to the chiral nanostructure is 45°. More specifically, the magnetic field may be a helical magnetic field formed by rotating at least the first magnetic body part and the second magnetic body part, and the rotation angle θ is each rotation of two magnetic bodies that are relatively rotated to form the long helical field. It may mean an angle (θ). The chirality of the chiral nanostructure may be imparted by application of a helical magnetic field. In addition, as described above, the chiral nanostructure may have a characteristic in which chirality is changed by application of a helical magnetic field. When a helical magnetic field is applied to the nanostructure in order to impart or change chirality, the helical magnetic field may be formed by the relative rotation of the first magnetic body part and the second magnetic body part facing each other. As the rotation angle θ of the first magnetic body part and the second magnetic body part changes, the chirality of the nanostructure is also changed.

Specifically, the magnitude of the chirality (τ) of the spiral magnetic field may be proportional to the magnitude value of sin(2θ). For example, when the respective rotation angle θ of the two magnetic materials is 15°; and the ratio of the relative magnitudes of the chirality in the case of 165° is 0.5 based on the magnitude of the chirality (τ) of 1.0 when the rotation angle θ of the helical magnetic field is 45°.

The Pmax is a maximum peak value (mdeg) when circular dichroism spectroscopy is measured with respect to the chiral nanostructure manufactured through the manufacturing method. For example, when two or more peaks are derived from different wavelength regions, it means a value for one peak having the largest absolute value of the peak value. The Pmax is an absolute value and is expressed as a positive (+) value.

In one embodiment, with respect to the chiral nanostructure manufactured through the method for manufacturing the chiral nanostructure, when the value of Equation 1 satisfies about 0 to about 20, the modulation rate of chiral property is higher than that of the related art. An extremely fast effect can be implemented, and self-assembly can be substantially changed in real time.

In one embodiment, when the nanoparticles include spherical core-shell particles and the shell has a structure substantially surrounding the entire surface of the core, the value of Equation 1 is about 0 to about 3.0, for example , from about 0 to about 2.5, such as from about 0 to about 1.5, such as from about 0 to about 1.0. In this case, for example, the nanoparticles may include a core including a metal component; and a core-shell particle having a shell including a magnetic component.

When the nanoparticles include spherical core-shell particles, the shell has a structure substantially surrounding the entire surface of the core, and C is any value greater than 0 (zero), the value of Equation 1 is from about 0.01 to about 3.5, such as from about 0.01 to about 3.0, such as from about 0.01 to about 2.5, such as from about 0.01 to about 1.5, such as from about 0.01 to about 1.0.

The nanoparticles include spherical core-shell particles, the shell has a structure substantially surrounding the entire surface of the core, the C is any value greater than 0 (zero), and the B is 50 to 200 In the case of any one of the values in the range, the value of Equation 1 may be from about 0.01 to about 1.0, for example, from about 0.01 to about 0.80, for example, from about 0.01 to about 0.50.

In another embodiment, when the nanoparticles include spherical core-shell particles, and the shell has a half-shell structure substantially surrounding a portion of the surface of the core, the value of Equation 1 is about 0 to about 19.00 may be, for example, from about 0 to about 18.00, for example, from about 0 to about 17.00. In this case, for example, the nanoparticles may include a core including a magnetic component; and a core-shell particle having a shell including a metal component.

When the nanoparticles include spherical core-shell particles, the shell is a half-shell structure substantially surrounding a part of the surface of the core, and C is any one value greater than 0 (zero), the formula The value of 1 can be from about 1.00 to about 19.00, for example, from about 1.50 to about 19.00, for example, from about 2.00 to about 18.00, for example, from about 2.50 to about 17.00. have.

The nanoparticles include spherical core-shell particles, the shell has a half-shell structure substantially surrounding a part of the surface of the core, and C is any value greater than 0 (zero), and the B When is any value in the range of 50 to 200, the value of Equation 1 may be from about 1.00 to about 17.00, for example, from about 1.00 to 15.00, for example, from about 1.00 to 14.00. .

In another embodiment, when the nanoparticles include rod-shaped core-shell particles and the shell has a structure substantially surrounding the entire surface of the core, the value of Equation 1 may be about 0 to about 3.0 have. In this case, for example, the nanoparticles may include a core including a metal component; and a core-shell particle having a shell including a magnetic component.

When the nanoparticles include rod-shaped core-shell particles, the shell has a structure substantially surrounding the entire surface of the core, and C is any value greater than 0 (zero), the value of Equation 1 about 0.1 to about 3.5, such as about 0.1 to about 3.0, such as about 0.2 to about 3.5, such as about 0.2 to about 3.5, such as about 0.3 to about 3.5, such as , from about 0.3 to about 3.0.

The nanoparticles include rod-shaped core-shell particles, the shell has a structure substantially surrounding the entire surface of the core, the C is any value greater than 0 (zero), and the B is 75 to When it is any one value in the range of 200, the value of Equation 1 may be from about 0.1 to about 3.0, for example, from about 0.1 to about 2.0, for example, from about 0.1 to about 1.8.

6 schematically shows a part of the chiral nanostructure 200 manufactured according to an embodiment of the present invention.

Referring to FIG. 6 , the chiral nanostructure 200 includes two or more nanoparticle array structures 210 , and the nanoparticle array structure 210 includes at least one nanoparticle 22 . 1 structure 201; and a second structure 202 including at least one nanoparticle 22 and spaced apart from the first structure 201 .

The chiral nanostructure 200 is manufactured using a spiral magnetic field forming apparatus for imparting hand symmetry. Referring to FIGS. 1 and 6 , the chiral nanostructure 200 is the first magnetic material. The chirality of the spiral magnetic field 13 formed while the part and the second magnetic body part rotate may be transferred to have structural chirality corresponding thereto.

Specifically, the chiral nanostructure 200 may include two or more nanoparticle array structures 210 in a three-dimensional space. The nanoparticle array structure 210 includes at least one nanoparticle 22, respectively, and the nanoparticle 22 has a predetermined arrangement.

The nanoparticle array structure 210 may include a first structure 201 including at least one nanoparticle 22; and at least one nanoparticle 22 , and may include a second structure 202 spaced apart from the first structure 201 . The first structure 201 and the second structure 202 refer to any two adjacent structures among the two or more nanoparticle array structures 210 . The components and structures of the nanoparticles 22 included in the first structure 201 and the nanoparticles 22 included in the second structure 202 may be the same or different.

In one embodiment, the spaced straight distance between the first structure 201 and the second structure 202 may be about 0.01 nm to about 50 μm. By adjusting the separation distance between any two structures in the above range, the variable speed of chirality of the nanoparticle array structure can be quickly implemented to a desired level, and it can be applied to optical or bio fields to realize an optimal function.

As described above, in the case of the helical magnetic field forming device for imparting hand symmetry, for the technical purpose of imparting chirality to non-chiral nanoparticles or modulating to have chirality different from existing chirality It can be used as an efficient and useful means. More specifically, the spiral magnetic field forming apparatus for imparting hand symmetry provides the advantage of being able to manufacture a large amount of chiral nanostructures in a relatively simple way through magnetic field application and control means, and utilizes a chemical synthesis method. It has the advantage of improving process easiness and efficiency and further improving precision compared to the conventional manufacturing method such as using a separate template or the like. In addition, it has an advantage of securing immediate real-time in imparting or modulating chirality.

The nanoparticles may be disposed in the magnetic field in a state of being dispersed in a solvent. More specifically, the nanoparticles may be accommodated in the receptor unit in a state in which one selected from the group consisting of distilled water, deionized water, alcohol, organic solvents, polymers, and combinations thereof is dispersed as a solvent.

The 'polymer' is a polymer having a weight average molecular weight (Mw) of about 500 or more, and may have a viscosity of about 5 cP to 6000 cP at room temperature, and may be composed of one type or a mixture of two or more types, and function as a dispersion medium for the nanoparticles. It is understood to be a generic term for any hydrophilic, hydrophobic, or amphiphilic liquid or solid polymer that can be used.

Preferably, the nanoparticles may be prepared as a colloidal solution using the solvent and disposed on the receptor. In the case of the colloidal solution, the chirality of the particles formed by the helical magnetic field may be more stable and precise.

Also preferably, the concentration of the nanoparticles in the colloidal solution may be, for example, about 5 μg/mL to about 500 mg/mL, for example, about 5 μg/mL to about 400 mg/mL, for example, For example, it may be about 10 mg/mL to about 400 mg/mL. According to the above range, it may be advantageous to impart chirality to the nanoparticles, and a three-dimensional chiral nanostructure composed of at least two or more nanoparticles may be formed more precisely.

The spiral magnetic field forming apparatus for imparting the hand symmetry may be one in which a spiral magnetic field is formed between the first magnetic body part and the second magnetic body part.

The spiral magnetic field forming device for imparting the hand symmetry adjusts the distance between the first magnetic body part and the second magnetic body part so that the spatial range of the magnetic field generated through the first magnetic body part and the second magnetic body part is adjusted. may be doing

The spiral magnetic field forming apparatus for imparting the hand symmetry adjusts the magnetic force of the first magnetic body part and the second magnetic body part or the distance between the first magnetic body part and the second magnetic body part to adjust the first magnetic body part and the second magnetic body part The magnetic flux density of the magnetic field generated through the magnetic body may be controlled.

As described above, by changing the helical magnetic field formed through the process of adjusting the spatial range of the magnetic field or the magnetic flux density of the magnetic field, it is to give the desired level of chirality to the nanoparticles disposed in the magnetic field.

The chirality of the nanoparticles disposed in the magnetic field may be adjusted to correspond to the chirality of the magnetic field, thereby finally forming a nanostructure having chirality. The fact that the chirality of the nanoparticles disposed in the magnetic field is adjusted to correspond to the chirality of the magnetic field means that the nanoparticles do not have chirality and the chirality of the magnetic field is transferred to the nanoparticles. It means that it has irrationality, or that the nanoparticles have chirality different from the existing chirality.

Referring to FIG. 1 , the helical magnetic field formed by the rotation of the first magnetic body part and the second magnetic body part has chirality induced from the mirror plane asymmetric structure. At least two or more nanoparticles disposed in the magnetic field may have a substantially equivalent level of chirality by transferring the chirality of the magnetic field. Accordingly, when at least one of the magnetic flux density, the magnetization direction, and the spatial range of the magnetic field is changed, the chirality of the magnetic field is changed, and accordingly, the chirality of the nanoparticles disposed in the magnetic field is also changed. For example, when the magnetic flux density is increased as a process of controlling a magnetic field, a peak on a circular dichroism spectroscopy graph of the nanoparticles is moved to a shorter wavelength side.

For example, a magnetic field formed while rotating the first magnetic body part and the second magnetic body part represents a spiral, and the angle at which the at least two magnetic bodies are relatively rotated through the magnetic field adjustment process; and changing at least one of the degree of parallelism of the at least two magnetic materials to adjust the magnetization direction of the magnetic field.

In addition, the magnetic field formed while the first magnetic body part and the second magnetic body part rotate represents a spiral, and the magnetic force of the first magnetic body part and the second magnetic body part; and changing at least one of a linear distance between the first magnetic body part and the second magnetic body part to adjust the magnetic flux density of the magnetic field.

Through the manufacturing method of the chiral nanostructure, it is possible to manufacture the chiral nanostructure as described above. In addition, a chiral nanostructure satisfying Equation 1 below may be manufactured through the method of manufacturing the chiral nanostructure.

[Formula 1a]

In Equation 1, A is the ratio of the average core particle diameter (nm) to the shell average thickness (nm) of the nanoparticles; or the ratio of the average core width (nm) to the shell average thickness (nm), B is the concentration (μg/mL) value of the nanoparticles, and C is the helical magnetic field applied to the chiral nanostructure. When the rotation angle (θ) is 45°, the ratio of the relative chirality size when the size value of the chirality (τ) is 1.0, and the P _max is the B and C is the absolute value of the maximum peak value of the Circular Dichroism Spectroscopy under condition.

The description of Equation 1 and each factor constituting it is the same as described above in relation to the chiral nanostructure.

The magnetic plasmon particles have arrangement variability due to the application of a magnetic field. When a magnetic field is applied to the magnetic plasmon particles, the 'array variability due to the application of a magnetic field' refers to a characteristic of being arranged in a predetermined arrangement according to the applied magnetic field. Based on this arrangement variability, the magnetic plasmon particles can manufacture a three-dimensional structure having a predetermined alignment structure comprising the magnetic plasmon particles by a relatively simple means of applying a magnetic field.

Specifically, in one embodiment, the magnetic plasmon particles may form a particle arrangement structure when a magnetic field is applied. Also, in one embodiment, the entire structure of the nanostructure including at least one particle array structure may exhibit chirality. That is, the magnetic plasmon particles may function as one configuration of a nanostructure having chirality.

The chiral nanostructure according to another embodiment of the present invention may be manufactured with a helical magnetic field forming device for imparting hand symmetry.

In the case of using the spiral magnetic field forming device for imparting hand symmetry, it provides the advantage of being able to manufacture a large amount of chiral nanostructures in a relatively simple way through magnetic field application and control means, using chemical synthesis methods, or Compared to a conventional manufacturing method such as using a separate template, process easiness and efficiency are improved, and further, precision is improved.

By applying particles satisfying each of the above-described characteristics as the magnetic plasmon particles, the nanostructure including the same as one configuration may exhibit excellent structural chirality due to the application of a magnetic field. In particular, a precise and immediate structural change is possible even with repeated magnetic field application to the nanostructure, and accordingly, an effect of immediate/real-time adjustment of chirality may be realized.

In one embodiment, the magnetic field applied to the magnetic plasmonic particles may be a spiral magnetic field. That is, the variability due to the magnetic field application of the magnetic plasmon particles may be, specifically, the variability due to the helical magnetic field application. By changing the arrangement of the magnetic plasmon particles by the helical magnetic field applied thereto, by forming a corresponding structural arrangement, the nanostructure having the overall structure of chirality can be efficiently obtained.

The nanostructure may be a structure having chirality prepared by applying a helical magnetic field to a particle dispersion of non-chirality in which the magnetic plasmon particles are irregularly dispersed. That is, not only the existing chirality of the nanostructure is variable by the application of the spiral magnetic field, but also the initial chirality itself may be imparted by the application of the spiral magnetic field. More specifically, by placing the dispersion in which the magnetic plasmon particles are dispersed in the dispersion medium in a helical magnetic field formed between two magnetic bodies that are relatively rotated at a predetermined angle (θ), it is possible to prepare a nanostructure with the first chirality. have.

The chiral nanostructure manufactured as a helical magnetic field forming device for imparting hand symmetry can be widely used in various optical devices and biosensor fields requiring polarization functions, and in particular, since precise and immediate modulation of chiral properties is possible, It can serve as an active and dynamic optical activation means for next-generation displays, such as 3D and holographic displays, that require ultra-fast transitions, real-time adjustments, and sophisticated color reproduction.

The present invention provides an apparatus capable of manufacturing a chiral nanostructure exhibiting nanoscale precision.

The present invention makes it possible to manufacture a chiral nanostructure with improved precision and process easiness by using the device.

The present invention provides the advantage of being able to manufacture a large amount of chiral nanostructures through a method of manufacturing a chiral nanostructure with a simpler process and higher precision compared to the conventional method using the above apparatus, and can be used in more diverse fields. It allows the iral nanostructure to be utilized.

The present invention has the advantage of ensuring immediate real-time not only in the case of providing chirality for the first time, but also in the modulation of additional chirality as needed.

The chiral nanostructure manufactured according to the present invention can be widely used in various optical devices and biosensor fields that require polarization function. It can serve as an active and dynamic optical activation means for next-generation displays such as 3D and holographic displays that require realization.

1 shows a schematic configuration and principle according to an embodiment of the present invention.
Figure 2 schematically shows the nanoparticles disposed in the receiving portion according to an embodiment of the present invention.
Figure 3 schematically shows a cross-section of various types of nanoparticles capable of imparting chirality manufactured according to an embodiment of the present invention.
4 is a photograph showing a spherical core-shell particle according to an embodiment.
5 is a photograph showing a rod-shaped core-shell particle according to an embodiment.
6 is a perspective view schematically illustrating a part of a chiral nanostructure manufactured by the method for manufacturing a chiral nanostructure according to an exemplary embodiment.
7 illustrates the principle of a manufacturing apparatus according to an embodiment of the present invention.
FIG. 8 shows a Circular Dichroism Spectroscopy (CD) spectrum for each concentration and rotation angle of a chiral nanostructure using an embodiment of the present invention.
FIG. 9 shows a Circular Dichroism Spectroscopy (CD) spectrum for each concentration and rotation angle of a chiral nanostructure using an embodiment of the present invention.
FIG. 10 shows a Circular Dichroism Spectroscopy (CD) spectrum for each concentration and rotation angle of a chiral nanostructure manufactured using an embodiment of the present invention.
11 is a diagram showing a Circular Dichroism Spectroscopy (CD) spectrum for each concentration and rotation angle of a chiral nanostructure manufactured using an embodiment of the present invention.
12 shows an example of use according to an embodiment of the present invention.
13 illustrates the concept of a configuration according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail so that those of ordinary skill in the art can easily carry out the present invention. However, the present invention may be embodied in several different forms and is not limited to the embodiments described herein.

1. Preparation example

Preparation Example 1: Synthesis of spherical core-shell nanoparticles (1)

A mixed solution was prepared by mixing 3.2 mmol of iron nitrate (Fe(NO ₃ ) ₃ ·9H ₂ O) with 40 mL of ethylene glycol (C ₂ H ₄ (OH) ₂ ) and stirring with a magnetic stirrer until completely dissolved. 35 mmol of sodium acetate (CH ₃ COONa) and 0.59 mmol of silver nitrate (AgNO ₃ ) were added to the mixed solution, and stirring was continued. When sodium acetate and silver nitrate are all dissolved, transfer the mixed solution to a Teflon container, put it in a metal container to withstand the pressure, and then heat to 210°C and keep for 4 hours. After the reaction, the synthesized nanoparticles are separated by centrifugation, etc., and purified with ethanol and deionized water. The separated nanoparticles are dried in a vacuum oven for 12 hours to prepare a powder.

Then, in order to disperse the nanoparticles in a polar solvent such as deionized water, a surface pretreatment step of attaching a hydrophilic functional group to the surface of the nanoparticles is performed. 1mg of the powder-form nanoparticles made in the nanoparticle synthesis step and 0.6mg of citric acid (citric aicd, HOC(COOH)(CH ₂ COOH) ₂ ) were placed in 1 mL of deionized water, sonicated for 2 hours, and then sonicated by centrifugation, etc. The particles are separated and purified with deionized water.

Preparation Example 2: Synthesis of spherical core-shell nanoparticles (2)

A mixed solution was prepared by mixing 1.6 mmol of iron nitrate (Fe(NO ₃ ) ₃ .9H ₂ O) with 40 mL of ethylene glycol (C ₂ H ₄ (OH) ₂ ) and stirring with a magnetic stirrer until completely dissolved. 35 mmol of sodium acetate (CH ₃ COONa) and 0.59 mmol of silver nitrate (AgNO ₃ ) were added to the mixed solution, and stirring was continued. When sodium acetate and silver nitrate are all dissolved, transfer the mixed solution to a Teflon container, put it in a metal container to withstand the pressure, and then heat to 210°C and keep for 4 hours. After the reaction, the synthesized nanoparticles are separated by centrifugation, etc., and purified with ethanol and deionized water. The separated nanoparticles are dried in a vacuum oven for 12 hours to prepare a powder.

Then, in order to disperse the nanoparticles in a polar solvent such as deionized water, a surface pretreatment step of attaching a hydrophilic functional group to the surface of the nanoparticles is performed. 1mg of the powder-form nanoparticles made in the nanoparticle synthesis step and 0.6mg of citric acid (citric aicd, HOC(COOH)(CH ₂ COOH) ₂ ) were placed in 1 mL of deionized water, sonicated for 2 hours, and then sonicated by centrifugation, etc. The particles are separated and purified with deionized water.

Preparation Example 3: Synthesis of rod-shaped core-shell nanoparticles

4.0mmol of iron chloride (FeCl ₃ ·6H ₂ O) was mixed with 40 mL of ethylene glycol (C ₂ H ₄ (OH) ₂ ) and stirred with a magnetic stirrer until completely dissolved to prepare a mixed solution. 35 mmol of sodium acetate (CH ₃ COONa) and 0.59 mmol of chloroauric acid (HAuCl ₄ ·3H ₂ O) were added to the mixed solution, and stirring was continued. When sodium acetate and chloroauric acid are all dissolved, transfer the mixed solution to a Teflon container, put it in a metal container to withstand pressure, and then heat to 200°C and keep for 8 hours. After the reaction, the synthesized nanoparticles are separated by centrifugation, etc., and purified with ethanol and deionized water. The separated nanoparticles are dried in a vacuum oven for 12 hours to prepare a powder.

Then, in order to disperse the nanoparticles in a polar solvent such as deionized water, a surface pretreatment step of attaching a hydrophilic functional group to the surface of the nanoparticles is performed. 1mg of the powder-form nanoparticles made in the nanoparticle synthesis step and 0.6mg of citric acid (citric aicd, HOC(COOH)(CH ₂ COOH) ₂ ) were placed in 1 mL of deionized water, sonicated for 2 hours, and then sonicated by centrifugation, etc. The particles are separated and purified with deionized water.

Preparation Example 4: Synthesis of spherical half-shell nanoparticles

20 mL of ethylene glycol (C ₂ H ₄ (OH) ₂ ) solution is mixed with 0.12 M of iron chloride (Fe(NO ₃ ) ₃ 9H ₂ O) and 34 mM citric acid, and stirred with a magnetic stirrer until completely dissolved. was prepared. Sodium acetate (CH ₃ COONa) is added to the mixed solution to adjust the concentration to 0.73 M. When all sodium acetate is dissolved, transfer the mixed solution to a Teflon container, put it in a metal container to withstand the pressure, and then heat to 200°C and keep for 10 hours. After the reaction, the synthesized nanoparticles are separated by centrifugation, etc., and purified with ethanol and deionized water. The separated nanoparticles are dried in a vacuum oven for 12 hours to prepare a powder.

Then, in order to disperse the nanoparticles in a polar solvent such as deionized water, a surface pretreatment step of attaching a hydrophilic functional group to the surface of the nanoparticles is performed. 1mg of the powder-form nanoparticles made in the nanoparticle synthesis step and 0.6mg of citric acid (citric aicd, HOC(COOH)(CH ₂ COOH) ₂ ) were placed in 1 mL of deionized water, sonicated for 2 hours, and then sonicated by centrifugation, etc. The particles are separated and purified with deionized water.

The slide glass is treated with a piranha solution to remove organic matter and foreign substances to prepare a hydrophilic surface. The slide glass is immersed in 0.2wt% PDDA (Polydialyldimethylammonium chloride) polymer solution so that the positively charged PVA polymer can be evenly distributed on the slide glass surface. After that, take out the glass slide and dry it, then drop the prepared magnetic nanoparticle solution so that the negatively charged nanoparticles can be uniformly attached to the positively charged PDDA surface, and the remaining solutions are gently washed with deionized water and dried. A coating of about 20 nm is applied to nanoparticles arranged on the slide glass as a single layer using gold sputtering. Thereafter, in order to stabilize the surface of the coated gold thin film, cysteine at a concentration of 1 mg/mL was added in excess, and then reacted for 12 hours at 60 rpm using a shaking incubator. After the reaction is completed, the nanoparticle monolayer is removed from the slide glass by ultrasonic treatment, the nanoparticles are separated with a magnet, and purified with deionized water.

2. Examples

Example 1: Chiral Nanostructure Containing Spherical Core-Shell Nanoparticles (1)

A spherical core-shell nanoparticle having a core containing silver (Ag) and _{a shell containing iron oxide (Fe 3} O _{4 ) was prepared.} The average diameter of the core is 61.4 (± 13.3) nm, and the average thickness of the shell is 54.3 (± 5.7) nm. Non-chiral nanoparticle dispersions were prepared by dispersing the nanoparticles in a solvent of deionized water so as to have respective concentrations as shown in Table 1 below. As the first magnetic body part 11 and the second magnetic body part 12, two neodymium magnets (50 x 10 x 2 mm, 0.2T) were prepared, and as shown in FIG. 1 , the same magnetization direction ( in the y-axis direction), and arranged to face each other at an interval of 3 cm. As shown in FIG. 2 , the achiral nanoparticle dispersion of each concentration was disposed in the central receptor part 21 between the first magnetic body part 11 and the second magnetic body part 12 . The first magnetic body part 11 and the second magnetic body part 12 are rotated by the same angular size with the y-axis as the rotation axis, the first magnetic body part 11 being rotated clockwise, and the second magnetic body part 12 ) was rotated counterclockwise. The magnitude of the angle between the long axes of the first magnetic body part 11 and the second magnetic body part 12 with the z-axis, that is, the magnitude of the rotation angle θ, was rotated as shown in Table 1 below. Thus, the chiral nanostructure of Example 1 was prepared.

Concentration (B)
[μg/mL] θ
[°] τ Relative Ratio (C)
(|sin2θ|)
[θ=degree] CD spectrum [mdeg] (A*B*C)/Pmax
(A=61.4/54.3) @ around 680nm @ around 830nm Pmax Example 1-1 25 0 0.00 24.0099 -27.7944 27.7944 0.00 Example 1-2 50 0 0.00 -1.18151 -3.35958 3.35958 0.00 Examples 1-3 75 0 0.00 67.0504 -117.419 117.419 0.00 Examples 1-4 100 0 0.00 95.599 -174.176 174.176 0.00 Examples 1-5 125 0 0.00 59.8761 -168.584 168.584 0.00 Examples 1-6 150 0 0.00 62.7865 -196.911 196.911 0.00 Examples 1-7 175 0 0.00 41.5222 -158.031 158.031 0.00 Examples 1-8 200 0 0.00 24.2616 -142.455 142.455 0.00 Examples 1-9 25 15 0.50 -4.5823 14.4494 14.4494 0.98 Examples 1-10 50 15 0.50 -85.6535 220.452 220.452 0.13 Examples 1-11 75 15 0.50 -131.236 324.921 324.921 0.13 Examples 1-12 100 15 0.50 -261.17 721.541 721.541 0.08 Examples 1-13 125 15 0.50 -404.182 1147.69 1147.69 0.06 Examples 1-14 150 15 0.50 -443.853 1276.1 1276.1 0.07 Examples 1-15 175 15 0.50 -245.245 818.711 818.711 0.12 Examples 1-16 200 15 0.50 -415.379 1174.39 1174.39 0.10 Examples 1-17 25 30 0.87 -22.7185 79.474 79.474 0.31 Examples 1-18 50 30 0.87 -121.04 417.616 417.616 0.12 Examples 1-19 75 30 0.87 -272.214 646.457 646.457 0.11 Examples 1-20 100 30 0.87 -490.672 1414.71 1414.71 0.07 Example 1-21 125 30 0.87 -678.063 2063.78 2063.78 0.06 Example 1-22 150 30 0.87 -634.406 1913.76 1913.76 0.08 Example 1-23 175 30 0.87 -825.094 2361.52 2361.52 0.07 Example 1-24 200 30 0.87 -755.049 2214.15 2214.15 0.09 Examples 1-25 25 45 1.00 -20.9936 76.835 76.835 0.37 Example 1-26 50 45 1.00 -140.436 511.409 511.409 0.11 Example 1-27 75 45 1.00 -306.815 1080.49 1080.49 0.08 Example 1-28 100 45 1.00 -591.983 1926.45 1926.45 0.06 Example 1-29 125 45 1.00 -742.859 2263.11 2263.11 0.06 Examples 1-30 150 45 1.00 -722.538 2269.08 2269.08 0.07 Examples 1-31 175 45 1.00 -941.641 2738.09 2738.09 0.07 Examples 1-32 200 45 1.00 -1018.3 2892.83 2892.83 0.08 Examples 1-33 25 60 0.87 -20.8995 73.6665 73.6665 0.33 Examples 1-34 50 60 0.87 -88.4849 346.019 346.019 0.14 Examples 1-35 75 60 0.87 -276.003 781.403 781.403 0.09 Examples 1-36 100 60 0.87 -502.098 1540.75 1540.75 0.06 Examples 1-37 125 60 0.87 -655.969 2052.61 2052.61 0.06 Examples 1-38 150 60 0.87 -710.642 2167.07 2167.07 0.07 Examples 1-39 175 60 0.87 -780.289 2379.01 2379.01 0.07 Examples 1-40 200 60 0.87 -848.356 2460.57 2460.57 0.08 Examples 1-41 25 75 0.50 -0.245546 24.6635 24.6635 0.57 Examples 1-42 50 75 0.50 -36.2108 158.793 158.793 0.18 Examples 1-43 75 75 0.50 -143.936 461.295 461.295 0.09 Examples 1-44 100 75 0.50 -262.514 825.693 825.693 0.07 Examples 1-45 125 75 0.50 -359.163 1140.66 1140.66 0.06 Examples 1-46 150 75 0.50 -357.154 1284.65 1284.65 0.07 Examples 1-47 175 75 0.50 -436.247 1330.04 1330.04 0.07 Examples 1-48 200 75 0.50 -399.246 1214.5 1214.5 0.09 Examples 1-49 25 90 0.00 16.0777 -44.0767 44.0767 0.00 Examples 1-50 50 90 0.00 28.9884 -64.2371 64.2371 0.00 Examples 1-51 75 90 0.00 52.7822 -126.687 126.687 0.00 Examples 1-52 100 90 0.00 60.1336 -105.996 105.996 0.00 Examples 1-53 125 90 0.00 60.7256 -132.183 132.183 0.00 Example 1-54 150 90 0.00 44.4219 -102.583 102.583 0.00 Examples 1-55 175 90 0.00 54.9442 -120.422 120.422 0.00 Examples 1-56 200 90 0.00 28.7288 -86.9 86.9 0.00 Examples 1-57 25 105 0.50 34.9145 -105.617 105.617 0.13 Examples 1-58 50 105 0.50 74.5349 -224.161 224.161 0.13 Examples 1-59 75 105 0.50 231.221 -719.515 719.515 0.06 Examples 1-60 100 105 0.50 381.372 -1127.94 1127.94 0.05 Example 1-61 125 105 0.50 493.191 -1466.55 1466.55 0.05 Examples 1-62 150 105 0.50 472.662 -1430.01 1430.01 0.06 Examples 1-63 175 105 0.50 479.217 -1467.72 1467.72 0.07 Examples 1-64 200 105 0.50 440.318 -1416.95 1416.95 0.08 Examples 1-65 25 120 0.87 44.0728 -147.612 147.612 0.17 Example 1-66 50 120 0.87 115.376 -398.886 398.886 0.12 Example 1-67 75 120 0.87 348.892 -1100.23 1100.23 0.07 Examples 1-68 100 120 0.87 570.329 -1844.23 1844.23 0.05 Examples 1-69 125 120 0.87 803.536 -2343.33 2343.33 0.05 Example 1-70 150 120 0.87 754.928 -2261.11 2261.11 0.06 Example 1-71 175 120 0.87 899.43 -2568.77 2568.77 0.07 Example 1-72 200 120 0.87 905.293 -2470.57 2470.57 0.08 Example 1-73 25 135 1.00 51.5963 -186.348 186.348 0.15 Example 1-74 50 135 1.00 165.941 -582.582 582.582 0.10 Example 1-75 75 135 1.00 414.199 -1300.25 1300.25 0.07 Example 1-76 100 135 1.00 680.842 -2144.71 2144.71 0.05 Example 1-77 125 135 1.00 805.463 -2502.3 2502.3 0.06 Example 1-78 150 135 1.00 882.054 -2601.23 2601.23 0.07 Example 1-79 175 135 1.00 1071.95 -3049.28 3049.28 0.06 Example 1-80 200 135 1.00 958.416 -2714.1 2714.1 0.08 Example 1-81 25 150 0.87 48.8084 -159.532 159.532 0.15 Example 1-82 50 150 0.87 154.376 -515.826 515.826 0.09 Example 1-83 75 150 0.87 375.085 -1174.04 1174.04 0.06 Example 1-84 100 150 0.87 599.926 -1900.42 1900.42 0.05 Example 1-85 125 150 0.87 757.317 -2261.12 2261.12 0.05 Example 1-86 150 150 0.87 719.947 -2231.19 2231.19 0.07 Example 1-87 175 150 0.87 1072.8 -2985.31 2985.31 0.06 Example 1-88 200 150 0.87 999.777 -2777.72 2777.72 0.07 Example 1-89 25 165 0.50 37.7221 -117.342 117.342 0.12 Examples 1-90 50 165 0.50 96.7212 -317.234 317.234 0.09 Example 1-91 75 165 0.50 241.131 -748.105 748.105 0.06 Example 1-92 100 165 0.50 370.313 -1163.1 1163.1 0.05 Example 1-93 125 165 0.50 530.478 -1494.5 1494.5 0.05 Example 1-94 150 165 0.50 470.297 -1417.91 1417.91 0.06 Example 1-95 175 165 0.50 708.259 -1794.61 1794.61 0.06 Examples 1-96 200 165 0.50 471.786 -1363.09 1363.09 0.08 Maximum value of (A*B*C)/Pmax 0.98 Minimum value of (A*B*C)/Pmax 0.00 Minimum value of (A*B*C)/Pmax when C>0 0.05

Example 2: Chiral Nanostructure Containing Spherical Core-Shell Nanoparticles (2)

A spherical core-shell nanoparticle having a core containing silver (Ag) and _{a shell containing iron oxide (Fe 3} O _{4 ) was prepared.} The average diameter of the core is 50.2 (± 12.2) nm, and the average thickness of the shell is 56.3 (± 7.4) nm. Non-chiral nanoparticle dispersions were prepared by dispersing the nanoparticles in a solvent of deionized water to have respective concentrations as shown in Table 2 below. As the first magnetic part 11 and the second magnetic part 12, two neodymium magnets (50 x 10 x 2 mm, 0.2T) were prepared, and as shown in FIG. 1 , the same magnetization direction (y-axis direction) was disposed to face each other at an interval of 3 cm. As shown in FIG. 2, the achiral nanoparticle dispersion of each concentration was placed in the receptor part 21 in the center between the first magnetic body part 11 and the second magnetic body part 12. . The first magnetic body part 11 and the second magnetic body part 12 are rotated by the same angular size with the y-axis as the rotation axis, the first magnetic body part 11 being rotated clockwise, and the second magnetic body part 12 ) was rotated counterclockwise. The magnitude of the angle between the long axes of the first magnetic part 11 and the second magnetic part 12 with the z-axis, that is, the magnitude of the rotation angle θ, was rotated as shown in Table 2 below. Thus, the chiral nanostructure of Example 2 was prepared.

Concentration (B)
[μg/mL] θ
[°] τ Relative Ratio (C)
(|sin2θ|)
[θ=degree] CD spectrum [mdeg] (A*B*C)/Pmax
(A=50.2/56.3) @ around 550nm @ around 630nm Pmax Example 2-1 25 0 0.00 12.9887 -33.9227 33.9227 0.00 Example 2-2 50 0 0.00 24.0005 -69.5656 69.5656 0.00 Example 2-3 75 0 0.00 37.3188 -90.1883 90.1883 0.00 Example 2-4 100 0 0.00 44.8066 -147.669 147.669 0.00 Example 2-5 125 0 0.00 69.7232 -177.941 177.941 0.00 Example 2-6 150 0 0.00 73.5675 -232.129 232.129 0.00 Example 2-7 175 0 0.00 56.4886 -211.105 211.105 0.00 Examples 2-8 200 0 0.00 80.6551 -195.476 195.476 0.00 Examples 2-9 25 15 0.50 2.04169 19.0562 19.0562 0.58 Example 2-10 50 15 0.50 -13.2609 133.278 133.278 0.17 Example 2-11 75 15 0.50 -41.9411 319.499 319.499 0.10 Example 2-12 100 15 0.50 -71.6352 545.872 545.872 0.08 Examples 2-13 125 15 0.50 -115.016 751.164 751.164 0.07 Examples 2-14 150 15 0.50 -169.939 982.81 982.81 0.07 Examples 2-15 175 15 0.50 -252.55 1177.08 1177.08 0.07 Examples 2-16 200 15 0.50 -286.668 1196.82 1196.82 0.07 Example 2-17 25 30 0.87 -4.94052 55.0064 55.0064 0.35 Example 2-18 50 30 0.87 -21.8273 221.683 221.683 0.17 Examples 2-19 75 30 0.87 -66.9534 527.974 527.974 0.11 Examples 2-20 100 30 0.87 -140.085 898.497 898.497 0.09 Example 2-21 125 30 0.87 -201.536 1187.15 1187.15 0.08 Example 2-22 150 30 0.87 -285.584 1619.41 1619.41 0.07 Example 2-23 175 30 0.87 -433.604 2225.84 2225.84 0.06 Example 2-24 200 30 0.87 -486.3 2106.9 2106.9 0.07 Examples 2-25 25 45 1.00 -0.08542 55.9676 55.9676 0.40 Example 2-26 50 45 1.00 -21.1961 212.854 212.854 0.21 Example 2-27 75 45 1.00 -74.4058 589.566 589.566 0.11 Example 2-28 100 45 1.00 -155.121 1046.21 1046.21 0.09 Example 2-29 125 45 1.00 -210.311 1297.41 1297.41 0.09 Examples 2-30 150 45 1.00 -345.387 1916.35 1916.35 0.07 Example 2-31 175 45 1.00 -497.619 2605.74 2605.74 0.06 Example 2-32 200 45 1.00 -605.706 2554.89 2554.89 0.07 Example 2-33 25 60 0.87 0.161611 46.2883 46.2883 0.42 Example 2-34 50 60 0.87 -14.1837 166.475 166.475 0.23 Example 2-35 75 60 0.87 -53.0223 451.453 451.453 0.13 Example 2-36 100 60 0.87 -108.765 793.788 793.788 0.10 Example 2-37 125 60 0.87 -149.601 967.583 967.583 0.10 Example 2-38 150 60 0.87 -270.391 1566.68 1566.68 0.07 Example 2-39 175 60 0.87 -384.997 1989.45 1989.45 0.07 Examples 2-40 200 60 0.87 -505.936 2198.12 2198.12 0.07 Example 2-41 25 75 0.50 2.59645 15.2231 15.2231 0.73 Example 2-42 50 75 0.50 -0.765858 83.6581 83.6581 0.27 Example 2-43 75 75 0.50 -20.7056 211.067 211.067 0.16 Example 2-44 100 75 0.50 -46.9466 413.847 413.847 0.11 Example 2-45 125 75 0.50 -61.347 427.492 427.492 0.13 Example 2-46 150 75 0.50 -146.882 838.844 838.844 0.08 Example 2-47 175 75 0.50 -183.78 916.749 916.749 0.08 Example 2-48 200 75 0.50 -256.047 1226.8 1226.8 0.07 Example 2-49 25 90 0.00 9.84896 -18.8676 18.8676 0.00 Examples 2-50 50 90 0.00 15.4456 -28.7567 28.7567 0.00 Example 2-51 75 90 0.00 23.4234 -56.0573 56.0573 0.00 Example 2-52 100 90 0.00 26.461 -54.7599 54.7599 0.00 Example 2-53 125 90 0.00 33.0412 -52.6661 52.6661 0.00 Example 2-54 150 90 0.00 41.7176 -77.1626 77.1626 0.00 Example 2-55 175 90 0.00 34.1409 -58.5267 58.5267 0.00 Example 2-56 200 90 0.00 55.8616 -71.8682 71.8682 0.00 Example 2-57 25 105 0.50 12.1705 -45.612 45.612 0.24 Example 2-58 50 105 0.50 27.4317 -107.644 107.644 0.21 Example 2-59 75 105 0.50 58.5299 -267.077 267.077 0.12 Examples 2-60 100 105 0.50 94.0003 -458.404 458.404 0.10 Example 2-61 125 105 0.50 103.088 -503.227 503.227 0.11 Example 2-62 150 105 0.50 194.818 -833.629 833.629 0.08 Example 2-63 175 105 0.50 241.432 -981.791 981.791 0.08 Example 2-64 200 105 0.50 350.582 -1289.48 1289.48 0.07 Example 2-65 25 120 0.87 10.1605 -57.3501 57.3501 0.34 Example 2-66 50 120 0.87 29.1265 -136.643 136.643 0.28 Example 2-67 75 120 0.87 74.073 -357.38 357.38 0.16 Example 2-68 100 120 0.87 133.365 -661.947 661.947 0.12 Example 2-69 125 120 0.87 136.452 -655.09 655.09 0.15 Example 2-70 150 120 0.87 297.667 -1342.15 1342.15 0.09 Example 2-71 175 120 0.87 351.385 -1529.56 1529.56 0.09 Example 2-72 200 120 0.87 486.754 -1796 1796 0.09 Example 2-73 25 135 1.00 12.016 -51.161 51.161 0.43 Example 2-74 50 135 1.00 30.7176 -136.684 136.684 0.33 Example 2-75 75 135 1.00 74.6721 -368.175 368.175 0.18 Example 2-76 100 135 1.00 142.527 -695.904 695.904 0.13 Example 2-77 125 135 1.00 233.812 -1073.28 1073.28 0.10 Example 2-78 150 135 1.00 309.784 -1423.48 1423.48 0.09 Example 2-79 175 135 1.00 403.784 -1806.37 1806.37 0.09 Example 2-80 200 135 1.00 545.072 -1995.66 1995.66 0.09 Example 2-81 25 150 0.87 9.68342 -46.9737 46.9737 0.41 Example 2-82 50 150 0.87 26.3462 -110.558 110.558 0.35 Example 2-83 75 150 0.87 63.2917 -275.067 275.067 0.21 Example 2-84 100 150 0.87 121.576 -502.891 502.891 0.15 Example 2-85 125 150 0.87 175.334 -793.066 793.066 0.12 Example 2-86 150 150 0.87 274.307 -1201.31 1201.31 0.10 Example 2-87 175 150 0.87 371.011 -1444.21 1444.21 0.09 Example 2-88 200 150 0.87 433.043 -1554.62 1554.62 0.10 Example 2-89 25 165 0.50 9.81558 -33.4495 33.4495 0.33 Example 2-90 50 165 0.50 17.268 -66.056 66.056 0.34 Example 2-91 75 165 0.50 34.6347 -153.61 153.61 0.22 Example 2-92 100 165 0.50 64.7832 -273.244 273.244 0.16 Example 2-93 125 165 0.50 125.247 -509.581 509.581 0.11 Example 2-94 150 165 0.50 171.555 -721.413 721.413 0.09 Example 2-95 175 165 0.50 228.764 -870.148 870.148 0.09 Example 2-96 200 165 0.50 268.001 -915.525 915.525 0.10 Maximum value of (A*B*C)/Pmax 0.73 Minimum value of (A*B*C)/Pmax 0.00 Minimum value of (A*B*C)/Pmax when C>0 0.06

Example 3: A chiral nanostructure comprising rod-shaped core-shell nanoparticles (1)

A rod-shaped core-shell nanoparticle having a core containing gold (Au) and _{a shell containing iron oxide (Fe 3} O _{4 ) was prepared.} The average length of the core is 2454 (± 624) nm, the average width of the core is 78 (± 16) nm, and the average thickness of the shell is 107 (± 12) nm. Non-chiral nanoparticle dispersions were prepared by dispersing the nanoparticles in a solvent of deionized water to have respective concentrations as shown in Table 3 below. As the first magnetic part 11 and the second magnetic part 12, two neodymium magnets (50 x 10 x 2 mm, 0.2T) were prepared, and as shown in FIG. 1 , the same magnetization direction (y-axis direction) was disposed to face each other at an interval of 3 cm. As shown in FIG. 2 , the achiral nanoparticle dispersion of each concentration was disposed in the central receptor part 21 between the first magnetic body part and the second magnetic body part. The first magnetic body part 11 and the second magnetic body part 12 are rotated by the same angular size with the y-axis as the rotation axis, the first magnetic body part 11 being rotated clockwise, and the second magnetic body part 12 ) was rotated counterclockwise. The magnitude of the angle between the long axes of the first magnetic body part 11 and the second magnetic body part 12 with the z-axis, that is, the magnitude of the rotation angle θ, was rotated as shown in Table 3 below. Thus, the chiral nanostructure of Example 3 was prepared.

Concentration (B)
[μg/mL] θ
[°] τ Relative Ratio (C)
(|sin2θ|)
[θ=degree] CD spectrum [mdeg] (A*B*C)/Pmax
(A=78/107) @ around 560nm @ around 830nm Pmax Example 3-1 25 0 0.00 -7.53815 9.50373 9.50373 0.00 Example 3-2 50 0 0.00 -11.5166 11.6856 11.6856 0.00 Example 3-3 75 0 0.00 -19.4045 13.333 19.4045 0.00 Example 3-4 100 0 0.00 -30.2261 13.0284 30.2261 0.00 Example 3-5 125 0 0.00 -27.3712 29.2251 29.2251 0.00 Example 3-6 150 0 0.00 -22.7016 38.9029 38.9029 0.00 Example 3-7 175 0 0.00 -19.079 34.1915 34.1915 0.00 Example 3-8 200 0 0.00 -26.3219 35.9554 35.9554 0.00 Example 3-9 25 15 0.50 -7.91551 7.68037 7.91551 1.15 Example 3-10 50 15 0.50 -15.8674 -6.02037 15.8674 1.15 Example 3-11 75 15 0.50 -27.9142 -19.1392 27.9142 0.98 Example 3-12 100 15 0.50 -39.4368 -32.1212 39.4368 0.93 Examples 3-13 125 15 0.50 -51.6815 -47.6679 51.6815 0.88 Example 3-14 150 15 0.50 -57.5326 -65.4931 65.4931 0.84 Example 3-15 175 15 0.50 -70.7813 -100.152 100.152 0.64 Examples 3-16 200 15 0.50 -65.7547 -115.026 115.026 0.63 Example 3-17 25 30 0.87 -9.4047 0.259422 9.4047 1.68 Example 3-18 50 30 0.87 -20.5545 -14.4674 20.5545 1.54 Example 3-19 75 30 0.87 -35.1782 -35.3682 35.3682 1.34 Example 3-20 100 30 0.87 -54.9278 -64.9022 64.9022 0.97 Example 3-21 125 30 0.87 -70.683 -103.213 103.213 0.77 Example 3-22 150 30 0.87 -80.7226 -139.911 139.911 0.68 Example 3-23 175 30 0.87 -84.4237 -184.024 184.024 0.60 Example 3-24 200 30 0.87 -105.777 -236.778 236.778 0.53 Example 3-25 25 45 1.00 -8.93725 1.29636 8.93725 2.04 Example 3-26 50 45 1.00 -23.0299 -13.2333 23.0299 1.58 Example 3-27 75 45 1.00 -37.3763 -40.461 40.461 1.35 Example 3-28 100 45 1.00 -59.3599 -80.2965 80.2965 0.91 Example 3-29 125 45 1.00 -74.4613 -114.102 114.102 0.80 Examples 3-30 150 45 1.00 -93.3701 -167.345 167.345 0.65 Example 3-31 175 45 1.00 -93.1886 -216.908 216.908 0.59 Example 3-32 200 45 1.00 -109.779 -263.285 263.285 0.55 Example 3-33 25 60 0.87 -6.4495 2.78366 6.4495 2.45 Example 3-34 50 60 0.87 -14.6077 -12.3136 14.6077 2.16 Example 3-35 75 60 0.87 -29.8128 -33.7258 33.7258 1.41 Example 3-36 100 60 0.87 -49.5093 -60.2401 60.2401 1.05 Example 3-37 125 60 0.87 -63.1746 -96.4258 96.4258 0.82 Example 3-38 150 60 0.87 -82.6834 -146.269 146.269 0.65 Example 3-39 175 60 0.87 -76.156 -176.352 176.352 0.63 Examples 3-40 200 60 0.87 -74.7141 -206.697 206.697 0.61 Example 3-41 25 75 0.50 -6.55073 5.32714 6.55073 1.39 Example 3-42 50 75 0.50 -18.8469 -5.32564 18.8469 0.97 Example 3-43 75 75 0.50 -21.2838 -15.4706 21.2838 1.29 Example 3-44 100 75 0.50 -33.7699 -28.8007 33.7699 1.08 Example 3-45 125 75 0.50 -36.9541 -46.3082 46.3082 0.99 Example 3-46 150 75 0.50 -48.4698 -71.9071 71.9071 0.76 Example 3-47 175 75 0.50 -54.8074 -93.9875 93.9875 0.68 Example 3-48 200 75 0.50 -60.9551 -114.5 114.5 0.64 Example 3-49 25 90 0.00 -8.21705 5.6958 8.21705 0.00 Examples 3-50 50 90 0.00 -14.5284 4.16412 14.5284 0.00 Example 3-51 75 90 0.00 -19.2898 4.08091 19.2898 0.00 Example 3-52 100 90 0.00 -18.027 12.6545 18.027 0.00 Example 3-53 125 90 0.00 -21.2254 24.8205 24.8205 0.00 Example 3-54 150 90 0.00 -15.3822 22.9 22.9 0.00 Examples 3-55 175 90 0.00 -24.9115 20.5429 24.9115 0.00 Example 3-56 200 90 0.00 -23.7274 23.832 23.832 0.00 Example 3-57 25 105 0.50 -2.01906 8.26742 8.26742 1.10 Example 3-58 50 105 0.50 -4.33768 14.8651 14.8651 1.23 Example 3-59 75 105 0.50 -9.37984 28.0946 28.0946 0.97 Examples 3-60 100 105 0.50 -10.9829 52.7525 52.7525 0.69 Example 3-61 125 105 0.50 -5.55637 77.838 77.838 0.59 Example 3-62 150 105 0.50 2.34774 108.448 108.448 0.50 Example 3-63 175 105 0.50 -3.44082 129.594 129.594 0.49 Example 3-64 200 105 0.50 -1.00455 149.064 149.064 0.49 Example 3-65 25 120 0.87 -6.74832 8.49235 8.49235 1.86 Example 3-66 50 120 0.87 -3.26899 19.614 19.614 1.61 Example 3-67 75 120 0.87 -1.63751 42.1399 42.1399 1.13 Example 3-68 100 120 0.87 8.42136 87.5046 87.5046 0.72 Example 3-69 125 120 0.87 17.7691 125.622 125.622 0.63 Example 3-70 150 120 0.87 29.9982 180.58 180.58 0.53 Example 3-71 175 120 0.87 18.6498 204.748 204.748 0.54 Example 3-72 200 120 0.87 42.3768 244.464 244.464 0.52 Example 3-73 25 135 1.00 -4.69228 8.02431 8.02431 2.27 Example 3-74 50 135 1.00 -7.01615 15.3894 15.3894 2.37 Example 3-75 75 135 1.00 1.10383 51.6208 51.6208 1.06 Example 3-76 100 135 1.00 9.99771 90.5506 90.5506 0.81 Example 3-77 125 135 1.00 19.9972 135.318 135.318 0.67 Example 3-78 150 135 1.00 26.0874 195.643 195.643 0.56 Example 3-79 175 135 1.00 39.5219 234.553 234.553 0.54 Example 3-80 200 135 1.00 38.8694 293.858 293.858 0.50 Example 3-81 25 150 0.87 -6.71394 6.86092 6.86092 2.30 Example 3-82 50 150 0.87 -4.00949 12.8799 12.8799 2.45 Example 3-83 75 150 0.87 -2.05087 42.0491 42.0491 1.13 Example 3-84 100 150 0.87 2.5425 78.2846 78.2846 0.81 Example 3-85 125 150 0.87 17.0064 134.022 134.022 0.59 Example 3-86 150 150 0.87 15.4648 176.807 176.807 0.54 Example 3-87 175 150 0.87 39.1618 211.53 211.53 0.50 Example 3-88 200 150 0.87 35.0033 270.308 270.308 0.47 Example 3-89 25 165 0.50 -2.72344 3.83548 3.83548 2.38 Example 3-90 50 165 0.50 -6.24092 6.95336 6.95336 2.62 Example 3-91 75 165 0.50 -0.576269 24.7738 24.7738 1.10 Example 3-92 100 165 0.50 -6.19691 59.9633 59.9633 0.61 Example 3-93 125 165 0.50 2.06396 91.3203 91.3203 0.50 Example 3-94 150 165 0.50 9.68981 99.0606 99.0606 0.55 Example 3-95 175 165 0.50 7.16727 136.52 136.52 0.47 Example 3-96 200 165 0.50 8.96223 157.629 157.629 0.46 Maximum value of (A*B*C)/Pmax 2.62 Minimum value of (A*B*C)/Pmax 0.00 Minimum value of (A*B*C)/Pmax when C>0 0.46

Example 4: Chiral structure comprising spherical half-shell nanoparticles

A spherical half-shell nanoparticle having a core including iron oxide (Fe ₃ O ₄ ) and a shell including gold (Au) and a half-shell including a half-shell was prepared. . The average diameter of the core is 204.6 (±23.6) nm, and the average thickness of the shell is 22.8 (± 1.8) nm. Non-chiral nanoparticle dispersions were prepared by dispersing the nanoparticles in a solvent of deionized water so as to have respective concentrations as shown in Table 4 below. As the first magnetic part 11 and the second magnetic part 12, two neodymium magnets (50 x 10 x 2 mm, 0.2T) were prepared, and as shown in FIG. 1 , the same magnetization direction (y-axis direction) was disposed to face each other at an interval of 3 cm. As shown in FIG. 2 , the achiral nanoparticle dispersion of each concentration was disposed in the receptor part 21 in the center between the first magnetic body part 11 and the second magnetic body part 12 . The first magnetic body part 11 and the second magnetic body part 12 are rotated by the same angular size with the y-axis as the rotation axis, the first magnetic body 11 being rotated in a clockwise direction, and the second magnetic body part ( 12) rotated counterclockwise. The magnitude of the angle between the long axes of the first magnetic body part 11 and the second magnetic body part 12 with the z-axis, that is, the magnitude of the rotation angle θ, was rotated as shown in Table 4 below. Thus, the chiral nanostructure of Example 4 was prepared.

Concentration (B)
[μg/mL]
θθ
[°] τ Relative Ratio (C)
(|sin2θ|)
[θ=degree] CD spectrum [mdeg] (A*B*C)/Pmax
(A=204.6/22.8) @ around 450nm @ around 700nm Pmax Example 4-1 25 0 0.00 -13.7293 -9.37537 13.7293 0.00 Example 4-2 50 0 0.00 -26.8003 -19.6424 26.8003 0.00 Example 4-3 75 0 0.00 -40.3599 -27.4027 40.3599 0.00 Example 4-4 100 0 0.00 -61.3673 -49.9827 61.3673 0.00 Example 4-5 125 0 0.00 -64.7302 -63.3074 64.7302 0.00 Example 4-6 150 0 0.00 -82.6592 -71.9333 82.6592 0.00 Example 4-7 175 0 0.00 -78.9345 -97.0621 97.0621 0.00 Examples 4-8 200 0 0.00 -82.7787 -80.4553 82.7787 0.00 Examples 4-9 25 15 0.50 -11.437 -6.12388 11.437 9.80 Example 4-10 50 15 0.50 -0.387778 -28.7961 28.7961 7.79 Examples 4-11 75 15 0.50 8.87803 -38.657 38.657 8.70 Example 4-12 100 15 0.50 14.8943 -64.7364 64.7364 6.93 Examples 4-13 125 15 0.50 27.2106 -113.701 113.701 4.93 Examples 4-14 150 15 0.50 32.7927 -126.945 126.945 5.30 Examples 4-15 175 15 0.50 41.7736 -163.453 163.453 4.80 Examples 4-16 200 15 0.50 81.4048 -197.244 197.244 4.55 Example 4-17 25 30 0.87 -11.437 -6.12388 11.437 16.98 Examples 4-18 50 30 0.87 9.05278 -30.7624 30.7624 12.63 Examples 4-19 75 30 0.87 39.1174 -56.1303 56.1303 10.38 Examples 4-20 100 30 0.87 79.4493 -82.8562 82.8562 9.38 Example 4-21 125 30 0.87 97.5773 -137.605 137.605 7.06 Example 4-22 150 30 0.87 129.521 -176.785 176.785 6.59 Example 4-23 175 30 0.87 173.356 -212.988 212.988 6.38 Example 4-24 200 30 0.87 179.851 -248.184 244.184 6.26 Examples 4-25 25 45 1.00 -3.60336 -13.2538 13.2538 16.92 Example 4-26 50 45 1.00 20.658 -37.4083 37.4083 11.99 Example 4-27 75 45 1.00 50.3629 -60.2882 60.2882 11.16 Example 4-28 100 45 1.00 88.9416 -95.797 95.797 9.36 Example 4-29 125 45 1.00 127.573 -159.375 159.375 7.04 Examples 4-30 150 45 1.00 148.764 -202.892 202.892 6.63 Example 4-31 175 45 1.00 164.48 -244.317 244.317 6.43 Example 4-32 200 45 1.00 177.76 -275.326 275.326 6.52 Example 4-33 25 60 0.87 -8.39113 -13.7004 13.7004 14.18 Example 4-34 50 60 0.87 12.5795 -38.8445 38.8445 10.00 Example 4-35 75 60 0.87 46.6445 -54.6695 54.6695 10.66 Example 4-36 100 60 0.87 78.3133 -98.3385 98.3385 7.90 Example 4-37 125 60 0.87 100.229 -136.854 136.854 7.10 Example 4-38 150 60 0.87 136 -196.026 196.026 5.94 Example 4-39 175 60 0.87 152.98 -239.44 239.44 5.68 Examples 4-40 200 60 0.87 174.774 -258.659 258.659 6.01 Example 4-41 25 75 0.50 -13.1136 -11.9487 13.1136 8.55 Example 4-42 50 75 0.50 -2.90439 -25.3031 25.3031 8.86 Example 4-43 75 75 0.50 14.0841 -46.955 46.955 7.16 Example 4-44 100 75 0.50 25.5531 -65.2249 65.2249 6.88 Example 4-45 125 75 0.50 32.7731 -110.369 110.369 5.08 Example 4-46 150 75 0.50 38.7656 -150.619 150.619 4.47 Example 4-47 175 75 0.50 68.8032 -167.151 167.151 4.70 Example 4-48 200 75 0.50 80.1045 -181.408 181.408 4.94 Example 4-49 25 90 0.00 -13.6779 -11.4838 13.6779 0.00 Examples 4-50 50 90 0.00 -31.6212 -20.6161 31.6212 0.00 Example 4-51 75 90 0.00 -41.8544 -23.6395 41.8544 0.00 Example 4-52 100 90 0.00 -41.9537 -31.529 41.9537 0.00 Example 4-53 125 90 0.00 -89.1371 -56.5824 89.1371 0.00 Example 4-54 150 90 0.00 -74.274 -77.7345 77.7345 0.00 Example 4-55 175 90 0.00 -133.742 -62.0819 133.742 0.00 Example 4-56 200 90 0.00 -87.9446 -50.7764 87.9446 0.00 Example 4-57 25 105 0.50 -24.9615 -2.0642 24.9615 4.49 Example 4-58 50 105 0.50 -53.6922 -7.2385 53.6922 4.18 Example 4-59 75 105 0.50 -81.738 -9.26416 81.738 4.12 Examples 4-60 100 105 0.50 -129.965 0.163201 129.965 3.45 Example 4-61 125 105 0.50 -191.557 5.12119 191.557 2.93 Example 4-62 150 105 0.50 -229.336 -11.7384 229.336 2.93 Example 4-63 175 105 0.50 -239.939 22.9567 239.939 3.27 Example 4-64 200 105 0.50 -241.141 52.4878 241.141 3.72 Example 4-65 25 120 0.87 -30.2692 -0.84840 30.2692 6.42 Example 4-66 50 120 0.87 -76.1418 -0.62602 76.1418 5.10 Example 4-67 75 120 0.87 -128.125 3.04504 128.125 4.55 Example 4-68 100 120 0.87 -163.733 16.9155 163.733 4.74 Example 4-69 125 120 0.87 -244.645 36.2708 244.645 3.97 Example 4-70 150 120 0.87 -328.532 47.1086 328.532 3.55 Example 4-71 175 120 0.87 -336.89 100.448 336.89 4.04 Example 4-72 200 120 0.87 -346.413 119.458 346.413 4.48 Example 4-73 25 135 1.00 -30.1818 -0.43374 30.1818 7.43 Example 4-74 50 135 1.00 -77.7811 0.402123 77.7811 5.77 Example 4-75 75 135 1.00 -138.074 6.51752 138.074 4.87 Example 4-76 100 135 1.00 -208.923 25.7691 208.923 4.29 Example 4-77 125 135 1.00 -276.945 39.2789 276.945 4.05 Example 4-78 150 135 1.00 -331.597 56.2207 331.597 4.06 Example 4-79 175 135 1.00 -351.074 127.933 351.074 4.47 Example 4-80 200 135 1.00 -466.984 168.866 466.984 3.84 Example 4-81 25 150 0.87 -28.4136 -2.24077 28.4136 6.83 Example 4-82 50 150 0.87 -76.1401 -0.08146 76.1401 5.10 Example 4-83 75 150 0.87 -117.67 2.83803 117.67 4.95 Example 4-84 100 150 0.87 -179.737 12.7147 179.737 4.32 Example 4-85 125 150 0.87 -233.904 31.5423 223.904 4.15 Example 4-86 150 150 0.87 -311.735 39.6801 311.735 3.74 Example 4-87 175 150 0.87 -323.65 94.0516 323.65 4.20 Example 4-88 200 150 0.87 -326.197 120.249 326.197 4.76 Example 4-89 25 165 0.50 -25.1369 -5.97778 25.1369 4.46 Example 4-90 50 165 0.50 -54.1712 -8.91204 54.1712 4.14 Example 4-91 75 165 0.50 -85.2771 -16.5045 85.2771 3.94 Example 4-92 100 165 0.50 -112.405 -7.10573 112.405 3.99 Example 4-93 125 165 0.50 -172.165 -9.25674 172.165 3.26 Example 4-94 150 165 0.50 -204.38 -15.8375 204.38 3.29 Example 4-95 175 165 0.50 -226.903 14.977 226.903 3.46 Example 4-96 200 165 0.50 -262.556 26.2862 262.556 3.42 Maximum value of (A*B*C)/Pmax 16.98 Minimum value of (A*B*C)/Pmax 0.00 Minimum value of (A*B*C)/Pmax when C>0 2.93

3. Measurement example

Measurement Example 1: Circular Dichroism Spectroscopy (CD)

For each chiral nanostructure prepared in Examples 1 to 4, a scan rate of 500 nm/min, a data interval of 0.5 nm, and 200 nm to 900 nm using a circular dichroism spectrometer (JASCO, J-1500) Spectra were obtained under the condition of a wavelength range of

Spectra of the chiral nanostructures of Examples 1 to 4 are as shown in FIGS. 8 to 11, respectively. 8 to 11 , it can be seen that the chiral nanostructures of Examples 1 to 4 each exhibit two peaks on the CD spectrum. These two peaks are derived from the core and the shell of the nanoparticles, respectively. The shape and concentration of the nanoparticles, the components of the core and the shell, the rotation angle of the magnetic material for imparting chirality, etc. can all affect the shape of the spectrum comprehensively. The wavelength range and peak value of each peak are described in Tables 1 to 4.

Measurement Example 2: Chirality of the magnetic field (τ)

In Examples 1 to 4, the size (°) of the rotation angle θ of the first magnetic body part 11 and the second magnetic body part 12 and the first magnetic body part 11 and the second magnetic body part 12 thereof 2 The relative ratio of the chirality (τ) of the helical magnetic field generated by the rotation of the magnetic part 12 was calculated through sin(2θ) and described in Tables 1 to 4, respectively.

Measurement example 3

_{In the spectrum of Measurement Example 1, the absolute value (P max} ) of the peak value of the peak having the maximum size among the two peaks is described in Tables 1 to 4, and using this, ( A * B * C)/P _max values were respectively obtained and described in Tables 1 to 4 above.

Referring to the Measurement Examples 1 to 3, it was confirmed that the chiral nanostructures of Examples 1 to 4 _{satisfy the (A * B * C)/P max} value of Equation 1 from 0 to 20. , through this, it was confirmed that the chirality corresponding to each helical magnetic field generated according to the rotation angle of the magnetic material was immediately and quickly displayed.

More specifically, in the chiral nanostructures of Examples 1 and 2, the nanoparticles thereof include spherical core-shell particles, and in the core-shell particles, the shell substantially surrounds the surface of the core. is the structure, and it was confirmed that the value of (A * B * C)/P _max in Equation 1 satisfies about 0.01 to about 1.0.

In addition, in the chiral nanostructure of Example 3, the nanoparticles include rod-shaped core-shell particles, and _{the value of (A * B * C)/P max} in Equation 1 is about 0.3 to It was confirmed that about 3.0 was satisfied.

In addition, in the chiral nanostructure of Example 4, the nanoparticles include spherical core-shell particles, and in the core-shell particles, the shell partially surrounds the surface of the core. -shell) structure, and it was confirmed that the value of (A * B * C)/P _max in Formula 1 satisfies about 0.01 to about 20.

In this way, the chiral nanostructure manufactured according to the method for manufacturing the chiral nanostructure is arranged in a predetermined arrangement by transferring the chirality of the magnetic field formed by the magnetic field forming step and the magnetic field adjusting step. It has chirality derived from the structural characteristics of the structure, and it was confirmed that the chirality is imparted and modulated in real time by a relatively simple technical means of applying a magnetic field. The provision of structural chirality and real-time self-assembly by the method of manufacturing the chiral nanostructure may have the advantage of securing wide applicability in a technical field to which it can be applied.

Although preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention as defined in the following claims are also provided. is within the scope of the

11: first magnetic body part
12: second magnetic body part
13: spiral magnetic field
14: core
15: shell
21: receptor part
22: nanoparticles
200: chiral nanostructure
201: first structure
202: second structure
210: nano particle array structure
L1, L2: Long axis of magnetic material (magnet)

Claims (11)

a first magnetic body for forming a magnetic field;
a second magnetic body spaced apart from the first magnetic body part by a predetermined distance; and
and a receptor part positioned between the first magnetic body part and the second magnetic body part to receive the nanoparticles;
Based on an imaginary center line passing through the first magnetic body part and the second magnetic body part at the same time, the first magnetic body part and the second magnetic body part rotate in opposite directions,
The nanoparticles include magnetic plasmonic particles, and the magnetic plasmon particles include a core; and a core-shell particle surrounding at least a portion of the surface of the core and having a shell including a component different from the component of the core, wherein the chiral nanostructure of Formula 1 Values from 0 to 20
Spiral magnetic field generator to impart hand symmetry:
[Equation 1]

In Equation 1, A is the ratio of the average core particle diameter (nm) to the shell average thickness (nm) of the nanoparticles; or the ratio of the average core width (nm) to the shell average thickness (nm), B is the concentration (㎍/mL) value of the nanoparticles, and C is the rotation angle (θ) of the helical magnetic field is 45 ° is the ratio of the relative chirality size when the size value of the chirality (τ) is 1.0, and the Pmax is the circularly polarized dichroism under the B and C conditions of the chiral nanostructure satisfying the A. It is the absolute value of the maximum peak value of the Circular Dichroism Spectroscopy. The method of claim 1,
The first magnetic body part and the second magnetic body part,
It is a panel shape with a predetermined thickness
Spiral magnetic field forming device to give hand symmetry. The method of claim 1,
The first magnetic body part and the second magnetic body part rotate at the same speed
Spiral magnetic field forming device to give hand symmetry. delete delete According to claim 1,
In the core-shell particle, one of the core and the shell includes a magnetic component, and the other includes a metal component,
Spiral magnetic field forming device to give hand symmetry. The method of claim 1,
The nanoparticles are accommodated in the receptor part in a state of being dispersed in a solvent,
The solvent is selected from the group consisting of distilled water, deionized water, alcohol, organic solvents, polymers, and combinations thereof.
Spiral magnetic field forming device to give hand symmetry. The method of claim 1,
A helical magnetic field is formed between the first magnetic body part and the second magnetic body part
Spiral magnetic field forming device to give hand symmetry. The method of claim 1,
The spatial range of the magnetic field generated through the first magnetic part and the second magnetic part is adjusted by adjusting the distance between the first magnetic part and the second magnetic part.
Spiral magnetic field forming device to give hand symmetry. The method of claim 1,
The magnetic flux density of the magnetic field generated through the first magnetic part and the second magnetic part by adjusting the magnetic force of the first magnetic part and the second magnetic part or the distance between the first magnetic part and the second magnetic part is adjusted. that
Spiral magnetic field forming device to give hand symmetry. A chiral nanostructure manufactured with the device for forming a spiral magnetic field for imparting hand symmetry according to claim 1 .

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