KR102326436B1 - Coating composition for contact lens, method of manufacturing the same and method of coating using the same - Google Patents

Abstract

The present invention relates to a coating solution composition for a contact lens capable of improving the surface slip property of a contact lens and forming a coating layer with improved hydrophilicity, a method for manufacturing the same, and a coating method using the same, and the coating solution composition for a contact lens according to the present invention, Because it is possible to improve the surface slip property of contact lenses and form a coating layer with improved hydrophilicity, it can reduce the friction coefficient of contact lenses to reduce damage to the eyelids and cornea, and serve as a protective coating on the surface of the eyelids and cornea for eye It can increase the comfort of the patient and has the advantage of forming a stabilized tear layer.

Description

Coating composition for contact lens, manufacturing method thereof, and coating method using the same

The present invention relates to a coating solution composition for a contact lens, a manufacturing method thereof, and a coating method using the same, and more particularly, a coating solution composition for a contact lens capable of improving the surface slip property of a contact lens and forming a coating layer with improved hydrophilicity; It relates to a manufacturing method and a coating method using the same.

Contact lenses are used instead of glasses to secure eyesight, and as life becomes more diverse and convenience is pursued, the use of contact lenses is gradually expanding.

A contact lens is a lens that is usually used in contact with the cornea of the eye for the purpose of vision correction, beauty, and treatment, and may be classified into a hard contact lens and a soft contact lens according to a material.

In addition to general contact lenses used for vision correction, therapeutic contact lenses are also used for eye treatment purposes, in this case for the purpose of protecting the eyes, covering the eyes, changing the degree of curvature of the cornea, or treating the retina. do.

In order for ordinary people to successfully wear contact lenses, it is essential to limit the effect of hypoxia on the cornea, and for this purpose, high water content lenses are used. It feels very dry and causes discomfort and various keratitis.

As an alternative to this, when a silicone-based hydrogel contact lens is worn, sufficient oxygen is supplied to the eyes, and there is no side effect of corneal edema due to hypoxia (Patent Document 1, Patent Document 2), but due to the nature of the silicone-based hydrogel material, the silicone content increases As a result, the hydrophilicity of the lens surface is reduced, giving discomfort to the wearer, and problems such as eye irritation, corneal pigmentation, and lens adhesion to the cornea occur.

In order to overcome this disadvantage, a method of increasing the hydrophilicity by plasma surface treatment of the lens surface was used (Patent Document 3), but it still has low wettability of the surface, which causes inconvenience to users, and the complicated process of plasma surface treatment in the manufacturing process is used. Additional processes are added, which increases the production cost.

As another method, a contact lens with increased wettability and moisture content was manufactured using a polymer without a plasma post-treatment process (Patent Document 4). However, the manufactured contact lens gradually loses its wearability as the internal wetting agent slowly escapes out of the lens. , there was a problem that caused discomfort when wearing.

Korean Patent Publication No. 10-2007-0067679 Korean Patent Publication No. 10-2015-0145399 Korean Patent Publication No. 10-2002-0005752 Korean Patent Publication No. 10-2003-0065306

The present invention has been devised to solve the problems of the prior art as described above, and an object of the present invention is to provide a coating solution composition for a contact lens that can improve the surface slip property of a contact lens and form a coating layer with improved hydrophilicity will be.

Another object of the present invention is to provide a method for preparing a coating solution composition for a contact lens that can improve the surface slip property of the contact lens and form a coating layer with improved hydrophilicity.

Another object of the present invention is to provide a method for coating using the coating solution composition for contact lenses.

In order to achieve the above object, the present invention provides a coating solution composition for a contact lens that forms a hydrophilic surface layer on a base material of a contact lens, the composition comprising purified water, a hydrophilic polymer, polyethylene glycol, and a pH adjuster for contact lenses A coating composition is provided.

In addition, the present invention is a step of mixing 88-95.9% by weight of purified water, 0.1-2% by weight of a hydrophilic polymer, 2-5% by weight of polyethylene glycol and 2-5% by weight of a pH adjuster with respect to the total weight of the composition, and in the above It provides a method for preparing a coating solution composition for contact lenses, comprising the step of stirring the obtained mixture.

In addition, the present invention provides a step of heating the coating solution composition for contact lenses, dip coating the heated coating solution composition on the substrate of the contact lens, washing the substrate of the contact lens on which the coating solution composition is dip-coated, and then a buffer There is provided a coating method using a coating solution composition for contact lenses, comprising the steps of immersing in a solution, and sterilizing the immersed contact lens substrate.

In addition, the present invention provides a coating method using a coating solution composition for contact lenses, comprising the steps of adding the coating solution composition for contact lenses to a buffer solution, and sterilizing the buffer solution to which the coating solution composition is added.

The coating solution composition for a contact lens according to the present invention improves the surface slip of the contact lens and can form a coating layer with improved hydrophilicity, thereby reducing the friction coefficient of the contact lens, thereby reducing damage to the eyelid and cornea, and the eyelid It can increase eye comfort by acting as a protective coating on the cornea and corneal surface, and has the advantage of forming a stabilized tear layer.

In addition, the contact lens coated with the surface layer by the coating method according to the present invention prevents a decrease in the moisture content and oxygen permeability of the contact lens due to the reduction of protein deposits attached to the contact lens, and reduces the contact angle, which is induced when the contact lens is worn. It has the advantage of avoiding discomfort.

1 is a schematic diagram showing the structure of an interpenetrating polymer network (IPN) formed between a contact lens substrate and a hydrophilic surface layer.
Figure 2 shows the measurement result of the contact lens after coating by infrared spectroscopy (FTIR spectroscopy).
3 shows the results of measuring the protein adsorption amount of the contact lens after coating.
4 shows the results of measurements using an atomic force microscope AFM (Atomic Force Microscope Park AFM) on the surface layer-coated contact lens (methafilcon) prepared in Comparative Example 1. Referring to FIG.

A first embodiment of the present invention is a coating solution composition for a contact lens that forms a hydrophilic surface layer on a substrate of a contact lens, wherein the composition is a contact lens comprising purified water, a hydrophilic polymer, polyethylene glycol as a hydrocarbon-based surfactant, and a pH adjuster It relates to a coating solution composition for use.

The coating solution composition for contact lenses of the present invention may contain 88 to 95.9% by weight of the purified water based on the total weight of the composition. When the content of the purified water is out of the above range, there is a problem in that the predetermined purpose of forming a hydrophilic coating layer cannot be achieved.

The coating solution composition for contact lenses of the present invention may contain 0.1 to 2% by weight of the hydrophilic polymer based on the total weight of the composition. When the content of the hydrophilic polymer is out of the above range, the hydrophilic polymer has a unique property of being soluble in water and has a characteristic of absorbing water tens to hundreds of times its own volume. There is a problem in that the movement of the lens is felt as a lot of movement in the eyesight.

In the coating solution composition for contact lenses of the present invention, the hydrophilic polymer is selected from polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), sodium hyaluronate (HA), choline phosphate polymer, cellulose acetate, and sulfonated polymer. can be

The coating solution composition for contact lenses of the present invention may contain 2 to 5% by weight of the polyethylene glycols based on the total weight of the composition. Polyethylene glycol (PEG) refers to a hydrocarbon molecule that can have a variety of sizes, and the various sizes can have various physical properties and are used to lubricate the eye and make the eye surface easy to tolerate, so that the polyethylene glycol When the content of the liquid is out of the above range, there is a problem in that the dispersion effect of the lens surface is deteriorated.

In the coating solution composition for contact lenses of the present invention, the polyethylene glycol may be polyethylene glycol 400 (PEG 400), wherein the polyethylene glycol 400 is an addition polymer of ethylene oxide and water, HOCH ₂ (CH ₂ OCH ₂ ) _n CH ₂ OH (n is 7-9), a colorless, clear, viscous liquid with a slightly peculiar odor, soluble in water, methanol, ethanol, pyridine and ether, etc., absorbent, and freezing point 4-8 ° C. am.

The coating solution composition for contact lenses of the present invention may contain 2 to 5% by weight of the pH adjusting agent based on the total weight of the composition. When the content of the pH adjusting agent is out of the above range, when the contact lens composition is exposed to an acidic solution by adding a small amount of the pH adjusting agent to the composition due to the weak acidity of the contact lens monomer, the pH environment inside the composition temporarily becomes alkaline or neutral. By increasing the dissolution rate of the residual monomer in the acidic solution as much as possible, there is a problem in that the weight of the residual monomer in the contact lens composition cannot be remarkably reduced.

In the coating solution composition for contact lenses of the present invention, the pH adjusting agent may be sodium hydrogen carbonate, and the sodium hydrogen carbonate (NaHCO ₃ ) is also called sodium bicarbonate, acid sodium carbonate, sodium bicarbonate or sodium bicarbonate. It is a crystalline powder, with a specific gravity of 2.20.

In the coating solution composition for a contact lens of the present invention, the contact lens substrate comprises: a) a substrate component comprising organosiloxanyl (meth)acrylate, a fluorine-containing monomer, and dimethylacrylamide; b) acrylic acid; methacrylic acid; acrylamide; C1-C15 saturated or unsaturated alkyl acrylates or methacrylates; C1-C15 hydroxyalkyl acrylate or methacrylate substituted with 1 to 3 hydroxyl groups; and N,N-di(C1-C15 saturated or unsaturated alkyl) acrylamide, a base component comprising an acrylic polymer comprising a single compound or a mixture of two or more, c) a base component comprising an oligosaccharide together with an acrylic monomer; Or d) may include a base component selected from the base component including the hydrophilic acrylic polymer into which lysine is introduced, but is not limited thereto.

In the coating solution composition for contact lenses of the present invention, the contact lens substrate may further include a binder component. As the binder component, the type is not particularly limited as long as radical polymerization is possible, for example, styrene, p- or m-methylstyrene, p- or m-ethylstyrene, p- or m-chlorostyrene, p- or m-chloromethylstyrene, styrenesulfonic acid, p- or m- or t-butoxystyrene, methylac Tate, ethyl lactate, methyl (meth) acrylate, isobutyl (meth) acrylate, t-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, n-octyl (meth) acrylate, Lauryl (meth) acrylate, stearyl (meth) acrylate, 2-hydroxyethyl (meth) acrylate, polyethylene glycol (meth) acrylate, methoxy polyethylene glycol (meth) acrylate, glycidyl (meth) ) acrylate, dimethylaminoethyl (meth)acrylate, diethylaminoethyl (meth)acrylate, vinyl acetate, vinyl propionate, vinyl butyrate, vinyl ether, allyl butyl ether, allyl glycidyl ether, (meth) A polymer obtained by mixing one or more polymer monomers such as unsaturated carboxylic acids such as acrylic acid and maleic acid, alkyl (meth)acrylamide, and (meth)acrylonitrile and polymerizing them may be used as a polymer binder component.

Here, the solvent used for polymerization of the binder component is one capable of dissolving the above-mentioned monomers, for example, halogenated alkanes such as chloromethane, dichloromethane, chloroform, tetrachloromethane, dichloroethane, ethyl acetate, diethyl Ether, cyclohexane, benzene, toluene, etc. can be used without limitation.

In addition, the initiator used for polymerization of the binder component in the present invention is benzoyl peroxide, lauryl peroxide, o-chlorobenzoyl peroxide, o-methoxybenzoyl peroxide, t-butylperoxy-2-ethyl Peroxides such as hexanoate, t-butylperoxyisobutylate, 1,1,3,3-tetramethylbutylperoxy-2-ethylhexanoate, dioctanoyl peroxide, didecanoyl peroxide, etc. and azo compounds such as 2,2-azobisisobutyronitrile, 2,2-azobis(2-methylbutyronitrile), 2,2-azobis(2,4-dimethylvaleronitrile), etc. have.

In the present invention, the initiator is preferably added in an amount of 1 to 2 wt% based on the total monomer in consideration of effective initiation efficiency. Polymerization is possible even at a concentration of less than 1% by weight, but a long polymerization time is required to obtain a degree of polymerization of 90% or more. can

In addition, a crosslinking agent may be further included to enhance physical properties. The crosslinking agent that can be used at this time is one capable of radical polymerization, for example, divinylbenzene, 1,4-divinyloxybutane, divinylsulfone, diallyl phthalate, diallyl acrylamide, triallyl (iso) cyanurate, Allyl compounds such as trially trimellitate, (poly) ethylene glycol di (meth) acrylate, (poly) propylene glycol di (meth) acrylate, pentaerythritol tetra (meth) acrylate, pentaeryl Tritol tri (meth) acrylate, pentaerythritol di (meth) acrylate, trimethylolpropane tri (meth) acrylate, dipentaerythritol hexa (meth) acrylate, ipentaerythritol penta (poly)alkylene glycol di(meth)acrylates, such as (meth)acrylate and glycerol tri(meth)acrylate, etc. can be used.

In the present invention, the crosslinking agent is preferably used in the range of 0.1 to 0.3% by weight based on the total amount of the polymer monomer.

In the present invention, a dispersion stabilizer may be further included in addition to the polymer binder as described above. The dispersion stabilizer is a polymer soluble in an aqueous phase, for example, gelatin, starch, hydroxyethyl cellulose, carboxymethyl cellulose. , polyvinylpyrrolidone, polyvinylalkyl ether, polyvinyl alcohol, polydimethylsiloxane/polystyrene block copolymer, and the like can be used.

The amount of the dispersion stabilizer used is preferably 1 to 5% by weight based on the total polymer binder component. In the case of less than 1% by weight, the stabilization ability is rapidly reduced, and when it exceeds 5% by weight, not only the viscosity of the system increases, but also the stabilization ability reaches an equilibrium, which may indicate a problem in that it cannot contribute to the stabilization ability.

When the coating solution composition for a contact lens of the present invention is coated on the substrate of the contact lens, a hydrophilic surface layer is formed. An interpenetratin polymer network (IPN) structure is formed between the contact lens substrate and the hydrophilic surface layer. will form

1 is a schematic diagram showing the structure of an interpenetrating polymer network (IPN) formed between a contact lens substrate and a hydrophilic surface layer, wherein a thick line in FIG. 1 indicates a contact lens substrate, such as a hydroxyethyl methacrylate (HEMA) network, and a dotted line indicates the network structure of the surface coating layer.

A second embodiment of the present invention relates to a method for preparing a coating solution composition for contact lenses, comprising the steps of mixing purified water, a hydrophilic polymer, polyethylene glycols and a pH adjusting agent, and stirring the mixture obtained above.

In the method for preparing the coating solution composition for a contact lens of the present invention, the mixing step includes 88 to 95.9% by weight of the purified water, 0.1 to 2% by weight of the hydrophilic polymer, 2 to 5% by weight of the polyethylene glycols, and 2 to the pH adjuster 5% by weight can be mixed.

In the method for preparing the coating solution composition for a contact lens of the present invention, the stirring may be performed for 20 to 50 minutes, preferably 25 to 35 minutes at a stirring speed of 100 to 300 rpm, preferably 150 to 250 rpm.

When the stirring speed and the stirring time are out of the above ranges, there is a problem in that the stirring cannot be effectively performed.

In the method for preparing the coating solution composition for a contact lens of the present invention, the polyethylene glycol may be polyethylene glycol 400, and the pH adjusting agent may be sodium hydrogen carbonate. For the characteristics of the polyethylene glycol 400 and sodium hydrogen carbonate, the contact lens As described in the coating solution composition.

A third embodiment of the present invention provides a step of heating the coating solution composition for a contact lens, dip coating the heated coating solution composition on a substrate of a contact lens, and a substrate of a contact lens having the coating solution composition dip coated. It relates to a coating method using a coating solution composition for contact lenses, comprising the steps of washing, immersing in a buffer solution, and sterilizing the substrate of the immersed contact lens.

In the coating method of the present invention, the temperature increase may be 50° C. or higher, preferably 50 to 130° C., and more preferably 60 to 121° C., when out of the temperature range of the elevated temperature, the contact lens substrate and hydrophilicity There is a problem that an interpenetratin polymer networks (IPN) structure cannot be formed between the surface layers.

In the coating method of the present invention, the dip coating can be performed for 10 to 60 minutes, preferably 20 to 50 minutes, but when it is out of the above range, there is a problem that the surface layer cannot be effectively formed.

In the coating method of the present invention, the washing may be performed for 10 to 60 minutes, preferably 20 to 50 minutes, but is not limited thereto.

In the coating method of the present invention, the buffer solution may include, for example, phosphate buffer saline or boric acid buffer saline, but is not limited thereto.

In the coating method of the present invention, the sterilization may be performed by a conventional method, autoclaving, for example, at a temperature of 121° C. for 20 minutes.

A fourth embodiment of the present invention relates to a coating method using a coating solution composition for contact lenses, comprising the steps of adding the coating solution composition for contact lenses to a buffer solution, and sterilizing the buffer solution to which the coating solution composition is added. .

In the coating method according to the fourth embodiment of the present invention, the buffer solution may include, for example, phosphate buffer saline or boric acid buffer saline, but is not limited thereto.

In the coating method according to the fourth embodiment of the present invention, the addition amount of the coating solution composition for contact lenses is 0.05 to 2.0% by weight, preferably 0.1 to 0.8% by weight, more preferably 0.3 to 2.0% by weight relative to the weight of the buffer solution. It may be 0.6% by weight, but if it is out of the range of the addition amount, there is a problem that the coating is not uniformly on the surface.

In the coating method according to the fourth embodiment of the present invention, the sterilization may be performed by a conventional method, for example, at a temperature of 121° C. for 20 minutes.

Hereinafter, the present invention will be described in detail through examples. However, these examples are only for explaining the present invention in detail, and the scope of the present invention is not limited by these examples.

<Example 1> Preparation of coating solution composition for contact lenses (1)

88% by weight of purified water, 2% by weight of polyvinylpyrrolidone as a hydrophilic polymer, 5% by weight of polyethylene glycol 400 and 5% by weight of sodium hydrogen carbonate were mixed.

The mixture obtained above was stirred for 30 minutes at a stirring speed of 200 rpm to prepare a coating solution composition for contact lenses.

<Example 2> Preparation of coating solution composition for contact lenses (2)

95% by weight of purified water, 0.1% by weight of polyvinylpyrrolidone as a hydrophilic polymer, 2% by weight of polyethylene glycol 400, and 2.9% by weight of sodium bicarbonate was carried out in the same manner as in Example 1, except that the coating solution composition for contact lenses was prepared.

<Example 3> Preparation of coating solution composition for contact lenses (3)

93 wt% of purified water, 1 wt% of polyvinyl alcohol as a hydrophilic polymer, 4 wt% of polyethylene glycol 400, and 2 wt% of sodium hydrogen carbonate were carried out in the same manner as in Example 1 to prepare a coating solution composition for contact lenses did.

<Example 4> Preparation of a contact lens coated with a surface layer (1)

As a soft contact lens, the contact lens coating solution composition prepared in Example 1 was coated on methafilcon (ionic polymer having a moisture content of 55%) to prepare a contact lens coated with a surface layer.

At this time, the coating method was performed as follows.

After the temperature of the coating solution composition for contact lenses was raised to 90° C., the heated coating solution composition was dip-coated on the base material of the contact lenses for 30 minutes.

The dip-coated contact lenses were washed for 30 minutes, immersed in a phosphate buffered saline solution for 30 minutes, and then sterilized at 121° C. for 20 minutes.

<Example 5> Preparation of a contact lens coated with a surface layer (2)

A contact lens coated with a surface layer was prepared in the same manner as in Example 4 except that the coating solution composition for contact lenses prepared in Example 2 was used.

<Example 6> Preparation of a contact lens coated with a surface layer (3)

A contact lens coated with a surface layer was prepared in the same manner as in Example 4, except that the coating solution composition for contact lenses prepared in Example 3 was used.

<Comparative Example 1> Preparation of a contact lens coated with a surface layer (4)

As a soft contact lens, the contact lens coating solution composition prepared in Example 1 was coated on methafilcon (ionic polymer having a moisture content of 55%) to prepare a contact lens coated with a surface layer. At this time, the coating was coated with a nonionic surfactant.

<Comparative Example 2> Preparation of a contact lens coated with a surface layer (5)

A contact lens coated with a surface layer was prepared in the same manner as in Comparative Example 1, except that the coating solution composition for contact lenses prepared in Example 2 was used.

<Comparative Example 3> Preparation of a contact lens coated with a surface layer (6)

A contact lens coated with a surface layer was prepared in the same manner as in Comparative Example 1, except that the coating solution composition for contact lenses prepared in Example 3 was used.

<Example 7> Preparation of a contact lens coated with a surface layer (7)

A contact lens coated with a surface layer was prepared by coating the coating solution composition for a contact lens prepared in Example 1 on hioxifilcon (a nonionic polymer having a moisture content of 49%) as a soft contact lens.

At this time, the coating method was performed as follows.

After adding 0.1% by weight of the coating solution composition for contact lenses prepared in Example 1 based on the weight of the solution to the phosphate buffered saline solution, the phosphate buffered saline solution to which the coating solution composition was added was sterilized at 121° C. for 20 minutes.

<Example 8> Preparation of contact lens coated with surface layer (8)

A contact lens coated with a surface layer was prepared in the same manner as in Example 7 except that the coating solution composition for contact lenses prepared in Example 2 was used.

<Example 9> Preparation of a contact lens coated with a surface layer (9)

A contact lens coated with a surface layer was prepared in the same manner as in Example 7 except that the coating solution composition for contact lenses prepared in Example 3 was used.

<Comparative Example 4> Preparation of a contact lens coated with a surface layer (10)

A contact lens coated with a surface layer was prepared by coating the coating solution composition for a contact lens prepared in Example 1 on hioxifilcon (a nonionic polymer having a moisture content of 49%) as a soft contact lens. At this time, the coating was coated with a nonionic surfactant.

<Comparative Example 5> Preparation of a contact lens coated with a surface layer (11)

A contact lens coated with a surface layer was prepared in the same manner as in Comparative Example 4 except that the coating solution composition for contact lenses prepared in Example 2 was used.

<Comparative Example 6> Preparation of a contact lens coated with a surface layer (12)

A contact lens coated with a surface layer was prepared in the same manner as in Comparative Example 4 except that the coating solution composition for contact lenses prepared in Example 3 was used.

<Example 10> Preparation of contact lens coated with surface layer (13)

A contact lens coated with a surface layer was prepared by coating the coating solution composition for a contact lens prepared in Example 1 on polymacon (a nonionic polymer having a moisture content of 38%) as a soft contact lens.

At this time, the coating method was performed as follows.

After adding 0.1% by weight of the coating solution composition for contact lenses prepared in Example 1 based on the weight of the solution to the phosphate buffered saline solution, the phosphate buffered saline solution to which the coating solution composition was added was sterilized at 121° C. for 20 minutes.

<Comparative Example 7> Preparation of a contact lens coated with a surface layer (14)

A contact lens coated with a surface layer was prepared by coating the coating solution composition for a contact lens prepared in Example 1 on polymacon (a nonionic polymer having a moisture content of 38%) as a soft contact lens. At this time, the coating was coated with a nonionic surfactant.

<Experimental Example 1> Contact angle measurement (1)

In order to confirm the hydrophilicity of the contact lens coated with the surface layer, the contact angle of the contact lens with the surface layer prepared in Examples 4 to 6 and Comparative Examples 1 to 3 with methafilcon as a contact lens was confirmed in the table below. 1 is shown.

At this time, the contact angle was measured using a contact angle meter (KRUSS DSA100), and the contact angles in Table 1 below are the contact angles of the contact lenses coated with the surface layer prepared in Examples 1 to 3 and Comparative Examples 1 to 3, respectively. The average value of the contact angle of the contact lens with the surface layer is shown.

process Example 4-6 Comparative Example 1-3 difference Average contact angle (°) 43.7381 47.3762 3.6381 Standard Deviation 0.7426 0.6465

As shown in Table 1, it can be seen that the contact angle value of the contact lens coated by the coating method of the present invention is smaller than that of the contact lens coated by the conventional method. can be checked

<Experimental Example 2> Contact angle measurement (2)

The contact angle was measured in the same manner as in Experimental Example 1, except that the contact angle of the contact lens coated with the surface layer prepared in Examples 7 to 9 and Comparative Examples 4 to 6 was checked for hioxifilcon as a contact lens. Table 2 shows.

process Examples 7-9 Comparative Example 4-6 difference Average contact angle (°) 41.0286 48.7333 7.7047 Standard Deviation 1.9650 0.8901

As shown in Table 2, it can be seen that the contact angle value of the contact lens coated by the coating method of the present invention is smaller than that of the contact lens coated by the conventional method. can be checked

<Experimental Example 3> Confirmation of coating of contact lenses

In order to check whether the contact lens was coated, the C = CN peak of the hydrophilic polymer of the contact lens coated with the surface layer prepared in Example 4 was measured using infrared spectroscopy (FTIR spectroscopy). .

In FIG. 2, "Uncoated polymacon" is a polymacon contact lens with no surface layer coated, "Coated polymacon" is a polymacon contact lens with a surface layer coated, "Uncoated methafilcon" is a methafilcon contact lens with an uncoated surface layer, "Coated methafilcon" is It refers to the methafilcon contact lens coated with the surface layer of Example 4.

As shown in Figure 2, it can be seen that the C = CN peak of the hydrophilic polymer is formed at ^{1662 ~ 1660 cm -1 , it can be confirmed that the coating solution composition of the present invention is coated.}

<Experimental Example 4> Protein adsorption amount measurement

The surface layer-coated contact lens (methafilcon) prepared in Example 4, the surface layer-coated contact lens (polymacon) prepared in Example 10, and the surface layer-coated contact lens (methafilcon) prepared in Comparative Example 1 And FIG. 3 shows the results of measuring the amount of protein adsorption on the contact lens (polymacon) coated with the surface layer prepared in Comparative Example 7.

At this time, the protein adsorption amount was measured as follows.

A protein solution was obtained by dissolving bovine serum albumin (BSA). One contact lens coated with a surface layer was put into the protein solution obtained above, and the protein was deposited at room temperature of 20±0.5° C. for 2 hours.

Then, 1 ml of PBS and the contact lens on which the protein was deposited were placed in a vial, and the protein was released for 16 hours. The protein adsorbed amount was measured by measuring the absorbance at a wavelength of 595 nm after the contact lens and the protein solution (20 μl) on which the protein was deposited were placed in a 96 well plate, 160 μl of Bradford reagent was added, and the mixture was well mixed.

Referring to FIG. 3 , it can be seen that the absorbance of the contact lens coated with the surface layer by the coating method according to the present invention is lower than that of the contact lens coated with the surface layer by the coating method according to the prior art.

As described above, the contact lens coated with the surface layer by the coating method according to the present invention prevents a decrease in moisture content and oxygen permeability of the contact lens due to the reduction of protein deposits attached to the contact lens, and reduces the contact angle when wearing the contact lens. It has the advantage of preventing discomfort caused.

<Experimental Example 5> Coating confirmation through surface measurement of contact lenses

FIG. 4 shows the measurement results of the contact lens (methafilcon) coated with the surface layer prepared in Comparative Example 1 using AFM using AFM.

As shown in FIG. 4 , it can be seen that the pores are reduced according to the degree of coating, and a hydrophilic polymer is formed, so that it can be confirmed that the coating solution composition of the present invention is coated.

Although described with reference to preferred embodiments and experimental examples of the present invention as described above, those of ordinary skill in the art will not depart from the spirit and scope of the present invention as set forth in the claims below. It will be understood that various modifications and variations of the present invention may be made therein.

The coating solution composition for a contact lens according to the present invention can improve the surface slip property of the contact lens and form a coating layer with improved hydrophilicity, thereby reducing the friction coefficient of the contact lens, thereby reducing damage to the eyelid and cornea, and the eyelid Since it can increase eye comfort by acting as a protective coating for the corneal surface and form a stabilized tear layer, it can be usefully applied to the technical field to which the present invention pertains.

Claims (10)

A coating solution composition for contact lenses for forming a hydrophilic surface layer on a base material of a contact lens, comprising:
Comprising the total weight of the composition, purified water 88-95.9% by weight, polyvinylpyrrolidone 0.1-2% by weight, polyethylene glycols 2-5% by weight and pH adjuster 2-5% by weight,
The hydrophilic surface layer forms an interpenetrating polymer network structure between the contact lens substrate and the
The coating solution composition lowers the contact angle of the contact lens and reduces the coefficient of friction,
The contact angle of the contact lens is a coating solution composition for a contact lens, characterized in that 41.0286 to 43.7381.
delete The coating solution composition for contact lenses according to claim 1, wherein the polyethylene glycol is polyethylene glycol 400.
The coating solution composition for contact lenses according to claim 1, wherein the pH adjusting agent is sodium hydrogen carbonate.
The method of claim 1, wherein the contact lens substrate comprises: a) a substrate component comprising organosiloxanyl (meth)acrylate, a fluorine-containing monomer, and dimethylacrylamide;
b) acrylic acid; methacrylic acid; acrylamide; C1-C15 saturated or unsaturated alkyl acrylates or methacrylates; C1-C15 hydroxyalkyl acrylate or methacrylate substituted with 1 to 3 hydroxyl groups; and a base component comprising an acrylic polymer comprising a single compound or a mixture of two or more selected from N,N-di(C1-C15 saturated or unsaturated alkyl) acrylamide;
c) a base component comprising an oligosaccharide together with an acrylic monomer, or
d) A coating solution composition for a contact lens, comprising a base component selected from base components comprising a hydrophilic acrylic polymer into which lysine is introduced.
Claims 1, 3 to 5 step of heating the coating solution composition for a contact lens of any one of claims to 50 ~ 130 ℃;
dip coating the heated coating solution composition on the substrate of the contact lens; washing the substrate of the contact lens dip-coated with the coating solution composition and then immersing it in a buffer solution; and
A coating method using a coating solution composition for a contact lens, comprising the step of sterilizing the base material of the immersed contact lens.
The method of claim 6, wherein the dip coating is performed for 10 to 60 minutes, the washing is performed for 10 to 60 minutes, and the buffer solution is phosphate buffered saline. .
A method comprising: adding the coating solution composition for contact lenses according to any one of claims 1 to 5 to the buffer solution, wherein the amount of the coating solution composition for contact lenses is 0.05 to 2.0% by weight based on the weight of the buffer solution; and
A coating method using a coating solution composition for contact lenses, comprising the step of sterilizing a buffer solution to which the coating solution composition is added.
The coating method according to claim 8, wherein the buffer solution is a phosphate buffered saline solution or a boric acid buffer solution. delete

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