KR102299374B1 - Bio signal measuring device and bio signal imaging device and brain imaging based brain disease diagnostic system - Google Patents

Abstract

The present invention provides a bio-signal measuring device, a bio-signal imaging device, and a brain that can easily calculate data on blood flow, blood flow velocity, and path length in a subject as data for the time domain, and based on this, simplify brain disease diagnosis. It relates to an image-based brain disease diagnosis system.
To this end, the biosignal measuring device includes a measuring unit including a plurality of light irradiators for irradiating light to a subject and a plurality of light receiving units for detecting the reflected light signals after the light irradiated from the plurality of light irradiators is reflected, and each and an arithmetic unit including a light irradiation control unit for controlling the light signal irradiated from the light irradiation unit and a signal processing unit for calculating data on the subject in a time domain based on the light signal detected by the light receiving unit.

Description

Bio-signal measuring device, bio-signal imaging device, and brain image-based brain disease diagnosis system

The present invention relates to a biosignal measuring device, a biosignal imaging device, and a brain image-based brain disease diagnosis system. It relates to a bio-signal measuring device, a bio-signal imaging device, and a brain image-based brain disease diagnosis system that can calculate and simplify brain disease diagnosis.

In general, brain imaging-based brain disease diagnosis is used in Alzheimer's disease (including dementia), central nervous system inflammation, dopaminergic nervous system, dyskinesias, epilepsy and mental disorders (depression, schizophrenia, etc.) and brain tumor diseases.

The number of dementia patients in Korea is expected to exceed 1 million by 2024. In addition, the market size for the diagnosis of Alzheimer's disease, Parkinson's disease, etc. is judged to be steadily increasing. Accordingly, there is a demand for technological development of brain disease diagnosis based on brain imaging.

Republic of Korea Patent Publication No. 2012-0111268 (Title of the invention: biosignal measurement system and method, published on October 10, 2012)

An object of the present invention is to solve the problems of the prior art, and it is possible to easily calculate the data on the blood flow volume, the blood flow velocity, and the path length in the subject as data for the time domain, and based on this, it is possible to simplify the diagnosis of brain diseases. To provide a biosignal measuring device, a biosignal imaging device, and a brain image-based brain disease diagnosis system.

According to a preferred embodiment for achieving the above object of the present invention, the biosignal measuring device according to the present invention includes a plurality of light irradiators for irradiating light to a subject, and the light irradiated from the plurality of light irradiators is reflected. a measurement unit including a plurality of light receiving units for detecting the reflected light signal; and an arithmetic unit including a light irradiation control unit for controlling the light signal irradiated from each light irradiation unit, and a signal processing unit for calculating the data for the subject in a time domain based on the light signal detected by the light receiving unit; do.

Here, a plurality of light emitting units and a plurality of light receiving units are alternately arranged in a grid shape so that the light emitting unit and the light receiving unit are alternately arranged at the outermost part of the measurement unit, and each light receiving unit located at the outermost part of the measuring unit is connected The virtual line has a rectangular shape, and the light receiving unit is disposed at four vertices of the rectangular shape.

Here, the light irradiation control unit is configured so that light modulated in response to at least two wavelength signals among three or more wavelength signals in at least two adjacent light irradiation units based on one light irradiation unit is sequentially irradiated with a time difference. At least two wavelength signals of three or more wavelength signals are sequentially irradiated with a time difference from at least two light irradiators adjacent to one light receiving unit, respectively, and a time difference from adjacent light irradiating units in one light receiving unit All optical signals corresponding to the modulated light sequentially irradiated are detected.

Here, the signal processing unit demodulates the optical signals all detected based on one light receiving unit in time series corresponding to the preset position of the light irradiation unit, and then restores the demodulated signal to the form of the wavelength signal before modulation, and the restored wavelength Based on the signal shape, the blood flow volume, blood flow velocity, and path length in the subject are calculated as data for the time domain.

Here, the light irradiation control unit, the light characterization unit for selecting the three or more wavelength signals; an optical modulator for generating three or more modulated signals by modulating the three or more wavelength signals selected by the optical characterization unit with different frequencies; and a light control unit for controlling each light emitting unit so that light modulated in response to at least two of the three or more wavelength signals is sequentially irradiated with a time difference from at least two adjacent light emitting units based on one light receiving unit. wherein the signal processing unit includes: a signal demodulator configured to time-series demodulate the optical signals detected based on one light receiving unit in a time series corresponding to a preset position of the light emitting unit to generate a demodulated signal; a signal restoration unit which restores each demodulated signal generated by the signal demodulator to the form of a wavelength signal before modulation; a signal operation unit for generating an operation signal by calculating the shape of the wavelength signal restored by the signal restoration unit; and a data calculation unit for calculating a blood flow volume, a blood flow velocity, and a path length in the subject corresponding to the position of the light irradiation unit, based on the operation signal generated by the signal calculation unit, as data for a time domain.

Here, a distance between the adjacent light emitting unit and the light receiving unit is 10 mm to 50 mm.

In addition, a distance between the adjacent light emitting unit and the light receiving unit is 25 mm to 35 mm.

A biosignal imaging apparatus according to the present invention includes: a biosignal measuring apparatus according to the present invention; and an image processing device configured to acquire image information on the subject based on the time domain data in the subject calculated by the signal processing unit, wherein the image processing unit includes: an interpolator for calculating an extinction coefficient by using a wavelength signal shape and normalizing it to calculate a characteristic of the subject; and an imaging unit configured to obtain image information on the subject by matching the time domain data of the subject calculated by the signal processing unit with the characteristics of the subject calculated by the interpolation unit.

The brain imaging-based brain disease diagnosis system according to the present invention comprises: the biosignal imaging device according to claim 5; a mobile terminal for receiving image information on the subject through wired/wireless communication with the imaging device; and a medical server that receives the image information on the subject through wireless communication with the portable terminal, wherein any one of the portable terminal and the medical server includes a corresponding patient based on the image information on the subject. Generates diagnostic information on the current state of the patient, and the diagnostic information is shared with each other through two-way communication between the portable terminal and the medical server and stored in the medical server.

The brain imaging-based brain disease diagnosis system according to the present invention further includes a network for sharing the diagnosis information through wireless communication with the portable terminal, and sharing the diagnosis information through wired/wireless communication with the network, and a smart medicine box for generating the patient's medication information in response to the diagnostic information and providing it to the network; a patient monitoring unit that shares the diagnosis information through wired/wireless communication with the network, generates patient monitoring information including patient's indoor environment information and patient's operation information in response to the diagnosis information, and provides it to the network; and a display unit that shares the diagnosis information through wired/wireless communication with the network, generates treatment content in response to the diagnosis information, and provides it to the network. further comprising at least one of, wherein the portable terminal provides the medical server with information provided to the network from at least one of the smart medicine box, the patient monitoring unit, and the display unit, and the provided information includes: The patient is notified of the provided information in the original state or the updated information updated in the original state through the mobile terminal, and the medical server matches and stores the provided information and the updated information.

According to the biosignal measuring device, biosignal imaging device, and brain image-based brain disease diagnosis system according to the present invention, data on blood flow volume, blood flow velocity, and path length in a subject are easily calculated as data for the time domain, and this Based on this, the diagnosis of brain disease can be simplified.

In addition, in the present invention, by using three or more wavelengths, it is possible to easily calculate the oxygenation and non-oxygenation state of blood, the hemoglobin state, and the path length of the cerebral blood vessels in the cerebral blood vessels included in the subject.

In addition, the present invention can specify the optical signal irradiated from each light irradiation unit through the detailed configuration of the light control unit, and can clarify the modulated signal in response to the blood flow volume, blood flow velocity, and path length in the subject.

In addition, the present invention can specify the modulated signal detected by one light receiving unit through the detailed configuration of the signal processing unit, and complete the data for the time domain in response to the blood flow volume, blood flow velocity, and path length in the subject. .

In addition, the present invention makes it possible to easily check the intensity and phase change of the optical signal detected by the light receiving unit by clarifying the characteristics of the optical signal detected by the light receiving unit by limiting the distance between the light emitting unit and the light receiving unit.

Also, according to the present invention, by reducing the limitation of the distance between the light emitting unit and the light receiving unit, it is possible to maintain the optical signal sensitivity in the light receiving unit in the best state.

In addition, the present invention can clearly acquire image information on the subject through the detailed configuration of the image processing apparatus.

In addition, the present invention can analyze the image information on the subject to share the diagnosis information of the patient online, and to treat the patient in various forms.

1 is a diagram illustrating a biosignal measuring apparatus according to an embodiment of the present invention.
2 is a block diagram showing a detailed configuration of a biosignal measuring apparatus according to an embodiment of the present invention.
3 is a diagram illustrating a biosignal imaging apparatus according to an embodiment of the present invention.
4 is a diagram illustrating a brain image-based brain disease diagnosis system according to an embodiment of the present invention.

Hereinafter, an embodiment of a biosignal measuring apparatus, a biosignal imaging apparatus, and a brain image-based brain disease diagnosis system according to the present invention will be described with reference to the accompanying drawings. At this time, the present invention is not limited or limited by the examples. In addition, in describing the present invention, detailed descriptions of well-known functions or configurations may be omitted in order to clarify the gist of the present invention.

1 and 2 , the biosignal measuring apparatus 100 according to an embodiment of the present invention may include a measuring unit 110 and an operation unit 120 .

The measurement unit 110 includes a plurality of light irradiation units 111 for irradiating light to the subject P, and a plurality of light irradiation units 111 for detecting the reflected light signals after the light irradiated from the plurality of light irradiation units 111 is reflected. It may include a light receiving unit 112 . Reference numeral 101 denotes a measurement area of the subject.

Here, the plurality of light irradiating units 111 and the plurality of light receiving units 112 are alternately arranged in a grid shape so that the light irradiating unit 111 and the light receiving unit 112 are alternately arranged on the outermost side of the measurement unit 110 . An imaginary line connecting each of the light receiving units 112 positioned at the outermost portion of the measurement unit 110 has a rectangular shape, and the light receiving units 112 are respectively disposed at four vertices of the rectangular shape.

In addition, the light emitting unit 111 and the light receiving unit 112 adjacent to each other are spaced apart from each other at equal intervals. At this time, the distance between the adjacent light irradiation unit 111 and the light receiving unit 112 is set to be 10mm to 50mm. In more detail, the distance between the light emitting unit 111 and the light receiving unit 112 adjacent to each other is set to be 25 mm to 35 mm. When the distance between the light emitting unit 111 and the light receiving unit 112 is out of the set range, the reception sensitivity is lowered and the characteristics of the optical signal detected by the light receiving unit 112 are not exhibited, but between the light emitting unit 111 and the light receiving unit 112 When the distance is set within the set range, it is possible to easily check the intensity and phase change of the optical signal detected by the light receiving unit 112 by clarifying the characteristics of the optical signal detected by the light receiving unit 112 . In particular, as the setting range is reduced, the optical signal sensitivity of the light receiving unit 112 may be maintained above the preset sensitivity. In particular, when the distance between the adjacent light emitting unit 111 and the light receiving unit 112 is 30 mm, the optical signal sensitivity of the light receiving unit 112 may be maintained at the best state.

The subject P is described as corresponding to the patient's head. Then, the biosignal measuring apparatus 100 according to an embodiment of the present invention measures the cerebral blood vessels inside the subject P according to the depth to calculate the blood flow rate, blood flow velocity, and path length in the subject P. can

The light irradiator 111 may irradiate at least one of an infrared region, a visible region, and an ultraviolet region as a light source represented by a laser, an LED, or a lamp.

In addition, the light receiving unit 112 may be spaced apart from each other on the upper and lower portions based on one light irradiator 111 , respectively spaced apart from the left and right portions, or may be spaced apart from each other on the upper and lower portions and the left and right portions. Then, at least three light receiving units 112 are disposed adjacent to one light emitting unit 111 based on one light emitting unit 111 .

Then, in the measurement unit 110 according to an embodiment of the present invention, at least two light irradiation units 111 adjacent to each other with respect to one light irradiation unit 111 correspond to at least two wavelength signals among three or more wavelength signals, respectively. Thus, the modulated light is sequentially irradiated with a time difference, and one light receiving unit 112 can detect all optical signals corresponding to the modulated light sequentially irradiated with a time difference from the adjacent light emitting unit 111 . In other words, the first modulated light among the three modulated lights is irradiated by the first light irradiator 111 of the at least three light irradiators 111 at the first time, and the second modulated light among the three modulated lights is irradiated for the second time is irradiated from the second light irradiation unit 111 of the at least three light irradiation units 111, and the third modulated light among the three modulated lights is the third light irradiation unit 111 of the at least three light irradiation units 111 at the third time. ) is investigated. In addition, one light receiving unit 112 may detect all of the optical signals corresponding to the modulated light irradiated with a time difference from the adjacent light emitting unit 111 .

The calculation unit 120 includes a light irradiation control unit 121 for controlling the light signal emitted from each light irradiation unit 111 and data on the subject P based on the light signal detected by the light receiving unit 112 . and a signal processing unit 122 that calculates in the time domain.

The light irradiation control unit is configured to sequentially irradiate light modulated in response to at least two wavelength signals among three or more wavelength signals from at least two light irradiation units 111 adjacent to each other with respect to one light receiving unit 112 with a time difference. control the light irradiation unit 111 of

In more detail, the light irradiation control unit generates three or more modulated signals by modulating the optical characterization unit 1211 for selecting three or more wavelength signals and the three or more wavelength signals selected by the optical characterization unit 1211 with different frequencies, respectively. The light modulated in response to at least two wavelength signals among the three or more wavelength signals in the light modulator 1212 and at least two light emitters 111 adjacent to each other with respect to the one light receiving unit 112 with a time difference A light control unit 1213 for controlling each light irradiation unit 111 to be sequentially irradiated may be included.

The three wavelength signals selected by the optical characterization unit 1211 may be, for example, 780 nm, 805 nm, and 830 nm near-infrared light.

In addition, as the three wavelength signals selected by the optical characterization unit 1211, for example, laser light having a wavelength of 355 nm, 532 nm, and 1064 nm may be selected.

The signal processing unit 122 demodulates the optical signals detected all based on one light receiving unit 112 in time series corresponding to the preset position of the light irradiation unit 111 , and then restores the demodulated signal to the wavelength signal form before modulation. Then, the blood flow volume, blood flow velocity, and path length in the subject P are calculated as data for the time domain based on the restored wavelength signal shape.

In other words, after demodulating the optical signals all detected by one light receiving unit 112 in time series corresponding to the preset position of the light emitting unit 111, the demodulated signal is restored to the wavelength signal form before modulation, and the restored Based on the wavelength signal shape, the blood flow volume, blood flow velocity, and path length in the subject P are calculated as data for the time domain.

In more detail, the signal processing unit 122 demodulates the optical signals detected all based on one light receiving unit 112 in time series corresponding to the preset position of the light emitting unit 111 to generate a demodulated signal. and a signal restoration unit 1222 that restores each demodulated signal generated by the signal demodulator 1221 to the form of a wavelength signal before modulation, and generates an operation signal by calculating the form of the wavelength signal restored by the signal restoration unit 1222 Based on the signal operation unit 1223 and the operation signal generated by the signal operation unit 1223 to and a data calculation unit 1224 for calculating data.

In other words, the signal demodulator 1221 may generate a demodulated signal by demodulating the optical signals all detected by one light receiving unit 112 in time series corresponding to the preset position of the light emitting unit 111 .

At this time, in generating the calculation signal in the signal operation unit 1223, according to the diameter of the brain blood vessel of the subject P, if the diameter of the brain blood vessel is smaller than the preset diameter, the data of the largest wave is used, and in the remaining cases, Data of a wavelength smaller than the data of the maximum wavelength may be used.

For example, the signal demodulator 1221 undergoes a demodulation process at least three times in response to the light irradiated from the light irradiator 111, and the signal restorer 1222 undergoes a restoration process at least three times in response to the demodulation process. The calculation unit 1223 may perform one calculation process by combining three restoration processes.

As another example, the signal demodulator 1221 undergoes a demodulation process at least three times in response to the light irradiated from the light irradiator 111, and the signal restorer 1222 collects at least three demodulation processes and undergoes one restoration process. , the signal operation unit 1223 may perform one operation process with a signal corresponding to one restoration process.

Here, the data calculating unit 1224 may calculate the blood flow volume, blood flow velocity, and path length in the subject P corresponding to the position of the light irradiation unit 111 as data for the time domain through various known types. .

Hereinafter, the biosignal imaging apparatus 1 according to an embodiment of the present invention will be described.

The biosignal imaging apparatus 1 according to an embodiment of the present invention may include the biosignal measuring apparatus 100 and the image processing apparatus 200 according to an embodiment of the present invention.

The image processing apparatus 200 may acquire image information on the subject P based on the data on the time domain of the subject P calculated by the signal processing unit 122 .

In more detail, the image processing apparatus 200 includes an interpolation unit 210 that calculates the characteristics of the subject P by obtaining an extinction coefficient using the wavelength signal shape restored by the signal processing unit 122 and normalizing it; Image information about the subject P is obtained by matching the time domain data of the subject P calculated by the signal processing unit 122 with the characteristics of the subject P calculated by the interpolation unit 210 . It may include an imaging unit 220 that

At this time, in normalizing the extinction coefficient in the storage unit, according to the diameter of the cerebral blood vessel of the subject P, when the diameter of the cerebral blood vessel is smaller than the preset diameter, the extinction coefficient of the minimum wavelength is normalized to the extinction coefficient of the maximum wavelength, , in other cases, the extinction coefficient of a wavelength greater than the minimum wavelength may be normalized to the extinction coefficient of the maximum wavelength.

Hereinafter, a brain image-based brain disease diagnosis system according to an embodiment of the present invention will be described.

A brain imaging-based brain disease diagnosis system according to an embodiment of the present invention provides a biosignal imaging apparatus 1 according to an embodiment of the present invention and an imaging device 1 through wired/wireless communication for a subject P. It may include a mobile terminal 3 that receives image information, and a medical server 4 that receives image information about the subject P through wireless communication with the mobile terminal 3 .

Then, any one of the portable terminal 3 and the medical server 4 generates diagnostic information on the current state of the patient based on the image information on the subject P. In this case, the diagnostic information may be shared with each other through bidirectional communication between the portable terminal 3 and the medical server 4 and stored in the medical server 4 .

The brain imaging-based brain disease diagnosis system according to an embodiment of the present invention may further include a network 2 for sharing diagnosis information through wireless communication with the portable terminal 3 .

In addition, the brain imaging-based brain disease diagnosis system according to an embodiment of the present invention shares diagnostic information through wired/wireless communication with the network 2 , and generates the patient's medication information in response to the diagnosis information and provides it to the network 2 . Sharing diagnostic information through wired and wireless communication with the smart medicine box 5 that ) and the display unit 9 that shares diagnostic information through wired/wireless communication with the network 2 and generates treatment content in response to the diagnostic information and provides it to the network 2 may include more.

Then, the portable terminal 3 may provide the medical server 4 with the information provided to the network 2 from at least one of the smart medicine box 5 , the patient monitoring unit and the display unit 9 . At this time, the provided information is notified to the patient as the provision information in the original state or the updated information in the original state through the portable terminal 3 . In addition, the medical server 4 may match and store the diagnosis information, the provision information, and the update information.

Here, the network 2 may also be connected to the imaging apparatus 1 through wireless communication. In response to the provided information and the updated information, the imaging apparatus 1 may update the image information, and either the portable terminal 3 or the medical server 4 may update and share the diagnosis information.

In more detail, if the smart medicine box 5 is further included, the portable terminal 3 may provide the patient's treatment information provided to the network 2 to the medical server 4 . At this time, the patient's medication information may be reported to the patient in the original state, and the patient's medication information may be updated with the patient's medication record and input to the portable terminal 3 . In addition, the medical server 4 may match and store the diagnosis information, the patient's medication information, and the patient's medication record.

Here, the network 2 may also be connected to the imaging apparatus 1 through wireless communication. At this time, the imaging device 1 may update the image information in response to the patient's medication information and the patient's medication record, and either the portable terminal 3 or the medical server 4 may update and share the diagnostic information. .

In addition, if the patient monitoring unit is further included, the portable terminal 3 may provide the patient monitoring information provided to the network 2 to the medical server 4 . In this case, the patient's monitoring information may be notified to the patient in the original state, or the patient may be informed of the changed information of the patient's monitoring information in order to change the patient's monitoring information. Such patient monitoring information and changed information for updating the patient monitoring information may be input to the portable terminal 3 . In addition, the medical server 4 may match and store the diagnosis information, the monitoring information of the patient, and the updated information of the monitoring information of the patient.

Here, the network 2 may also be connected to the imaging apparatus 1 through wireless communication. At this time, the imaging apparatus 1 updates the image information in response to the patient's monitoring information and the updated information about the patient's monitoring information, and either the portable terminal 3 or the medical server 4 updates the diagnosis information. can be shared.

The patient monitoring unit is provided in the room where the patient lives, and the patient monitoring unit includes a sensor unit 6 and home appliances 8 that detect the movement of the patient in the room, the patient's living pattern, and the indoor environment, and It may include at least one of the camera unit 7 for photographing the movement of the patient, the patient's life pattern, and the indoor environment.

In addition, when the display unit 9 is further included, the display unit 9 may provide treatment content in the form of virtual reality, augmented reality, or a combination thereof. The portable terminal 3 may provide the treatment content provided to the network 2 to the medical server 4 . In this case, the treatment content may notify the patient in the original state, or notify the patient of updated content including selection of whether to use the treatment content or whether to use the treatment content. Such treatment content and updated content may be input to the portable terminal (3). In addition, the medical server 4 may match and store the diagnosis information, the treatment content, and the updated content.

Here, the network 2 may also be connected to the imaging apparatus 1 through wireless communication. In this case, the imaging apparatus 1 may update the image information in response to the treatment content and the updated content, and any one of the portable terminal 3 and the medical server 4 may update and share the diagnosis information.

According to the above-described bio-signal measuring device 100, bio-signal imaging device 1, and brain image-based brain disease diagnosis system, data on blood flow volume, blood flow velocity, and path length in the subject P are stored in the time domain. It can be easily calculated with data, and based on this, brain disease diagnosis can be simplified.

In addition, by using three or more wavelengths, in the cerebral blood vessels included in the subject P, it is possible to easily calculate the oxygenation and non-oxygenation state of blood, the hemoglobin state, and the path length of the cerebral blood vessels.

In addition, through the detailed configuration of the light control unit 1213, the light signal irradiated from each light irradiation unit 111 can be specified, and the modulated signal can be generated in response to the blood flow rate, blood flow velocity, and path length in the subject P. can make it clear

In addition, it is possible to specify the modulated signal detected by one light receiving unit 112 through the detailed configuration of the signal processing unit 122, and the time domain corresponding to the blood flow rate, blood flow velocity, and path length in the subject P. data can be completed.

In addition, by clarifying the characteristics of the optical signal detected by the light receiving unit 112 by limiting the distance between the light emitting unit 111 and the light receiving unit 112 , the intensity and phase change of the optical signal detected by the light receiving unit 112 can be easily checked possible.

In addition, by reducing the limitation of the distance between the light emitting unit 111 and the light receiving unit 112 , the optical signal sensitivity of the light receiving unit 112 can be maintained in the best state.

In addition, image information on the subject P may be clearly obtained through the detailed configuration of the image processing apparatus 200 .

In addition, by analyzing the image information on the subject P, the diagnosis information of the patient can be shared online, and the patient can be treated in various forms.

Although the preferred embodiment of the present invention has been described with reference to the drawings as described above, those skilled in the art may vary the present invention in various ways without departing from the spirit and scope of the present invention as set forth in the following claims. may be modified or changed.

100: biosignal measuring device P: subject
110: measurement unit 101: measurement area 111: light irradiation unit
112: light receiving unit 120: arithmetic unit 121: light irradiation control unit
1211: light characterization unit 1212: light modulator 1213: light control unit
122: signal processing unit 1221: signal demodulation unit 1222: signal restoration unit
1223: signal operation unit 1224: data calculation unit
200: image processing unit 210: interpolation unit 220: image conversion unit
1: Imaging device 2: Network 3: Mobile terminal
4: Medical server 5: Smart medicine box 6: Sensor unit
7: Camera unit 8: Home appliance 9: Display unit

Claims (7)

A bio-signal measuring apparatus measuring a bio-signal by irradiating light to a subject and detecting the reflected light signal after the irradiated light is reflected, and an image processing apparatus for obtaining image information on the subject from the bio-signal measuring apparatus A biosignal imaging apparatus comprising a;
a mobile terminal for receiving image information on the subject through wired/wireless communication with the imaging device;
a medical server receiving image information on the subject through wireless communication with the mobile terminal;
a network for sharing diagnostic information through wireless communication with the mobile terminal;
a smart medicine box that shares the diagnosis information through wired/wireless communication with the network, generates medication information for a patient in response to the diagnosis information, and provides it to the network;
a patient monitoring unit that shares the diagnosis information through wired/wireless communication with the network, generates patient monitoring information including patient's indoor environment information and patient's operation information in response to the diagnosis information, and provides it to the network; and
a display unit for sharing the diagnosis information through wired/wireless communication with the network, generating treatment content in response to the diagnosis information, and providing the treatment content to the network; and
Any one of the portable terminal and the medical server generates diagnostic information on the current condition of the patient based on the image information on the subject,
The diagnosis information is shared with each other through two-way communication between the portable terminal and the medical server and stored in the medical server,
The portable terminal provides the medical server with information provided to the network from at least one of the smart medicine box, the patient monitoring unit, and the display unit,
The provided information notifies the patient with the provided information in the original state or the updated information of the provided information in the original state through the mobile terminal,
The medical server is a brain image-based brain disease diagnosis system, characterized in that matching and storing the provided information and the updated information,
The biosignal measuring apparatus may include: a measuring unit including a plurality of light irradiating units for irradiating light to a subject, and a plurality of light receiving units for detecting the reflected light signals after the light irradiated from the plurality of light irradiating units is reflected; and an arithmetic unit including a light irradiation control unit for controlling the light signal irradiated from each light irradiation unit, and a signal processing unit for calculating the data for the subject in a time domain based on the light signal detected by the light receiving unit; do,
A plurality of light emitting units and a plurality of light receiving units are alternately arranged in a lattice shape such that the light emitting unit and the light receiving unit are alternately arranged at the outermost portion of the measurement unit, and an imaginary line connecting each light receiving unit located at the outermost portion of the measuring unit has a rectangular shape, and the light receiving unit is disposed at four vertices in the rectangular shape,
The light irradiation control unit controls each light irradiation unit so that light modulated in response to three wavelength signals is sequentially irradiated with a time difference from at least two light irradiation units adjacent to each other based on one light irradiation unit,
At least two light emitters adjacent to one light receiving section are sequentially irradiated with three wavelength signals with a time difference, respectively, and in one light receiving section, light corresponding to modulated light sequentially irradiated from adjacent light emitters with a time difference All signals are detected,
The signal processing unit demodulates the optical signals all detected based on one light receiving unit in time series corresponding to the position of the preset light irradiation unit, and then restores the demodulated signal to the wavelength signal form before modulation, and the restored wavelength signal form based on the calculation of the blood flow volume, blood flow velocity, and path length in the subject as data for the time domain,
The light irradiation control unit may include: an optical characterization unit for selecting the three wavelength signals; an optical modulator for generating three modulated signals by modulating the three wavelength signals selected by the optical characterization unit with different frequencies; and a light control unit for controlling each light emitting unit so that light modulated in response to three wavelength signals is sequentially irradiated with a time difference from at least two adjacent light emitting units based on one light receiving unit;
The signal processing unit may include: a signal demodulator configured to time-series demodulated optical signals detected based on one light receiving unit in a time series corresponding to a preset position of the light emitting unit to generate a demodulated signal; a signal restoration unit which restores each demodulated signal generated by the signal demodulator to the form of a wavelength signal before modulation; a signal operation unit for generating an operation signal by calculating the shape of the wavelength signal restored by the signal restoration unit; and a data calculation unit that calculates the blood flow volume, blood flow velocity, and path length in the subject corresponding to the position of the light irradiation unit based on the operation signal generated by the signal calculation unit as data for the time domain;
The distance between the adjacent light irradiation unit and the light receiving unit is 30 mm,
The three wavelength signals are laser light having a wavelength of 355 nm, 532 nm and 1064 nm, respectively,
The patient monitoring unit includes a sensor unit and a home appliance unit for detecting the movement of the patient, the patient's living pattern, and the indoor environment, and a camera unit for photographing the movement of the patient, the patient's living pattern, and the indoor environment. A brain imaging-based brain disease diagnosis system.
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