KR102274435B1 - Composite of emulsion - Google Patents

Abstract

The present invention relates to a fine oil-in-water emulsion composition having fluidity for improving skin permeation, and more specifically, to a fine oil-in-water emulsion composition, wherein an emulsion has a micro-particle size by using a general HOMO Mixer by combining a thickener and an emulsifier, and particles have fluidity to penetrate through skin cell gaps.

Description

Microfluidic oil-in-water emulsion composition for improving skin permeation {COMPOSITE OF EMULSION}

The present invention relates to a fine oil-in-water emulsion composition having fluidity for improving skin permeation, and more particularly, by using a general HOMO Mixer by combining a thickener and an emulsifier, the emulsion has a micro-sized particle size, It relates to a fine oil-in-water emulsion composition designed to allow particles to have fluidity and penetrate through the skin cell gap.

The skin tissue of the human body is known to be a very effective barrier for blocking substances introduced from the external environment. The size of the skin cell gap is as fine as 80-300 nm, and the size of the active ingredient must also have a nano size in order for the ingredient showing an effective effect in cosmetics to pass through this gap.

As related prior art, Patent Publication No. 10-2020-0079672 "Nanoemulsion composition with size controlled and method for manufacturing same" (hereinafter referred to as 'Prior Art 1'), Patent Registration No. 10-1939880 "Cancer lesion" Hydrogel-based nanoemulsion for selective labeling and method for preparing the same" (hereinafter referred to as 'Prior Art 2'),

The prior art 1 relates to a technique capable of controlling the size of the nanoparticles of the nanoemulsion in nano units according to the length of the added nanocellulose,

The prior art 2 is an oily component that is an oil selected from the group consisting of soybean oil, olive oil, grape seed oil, canola oil, corn oil, mineral oil, silicone oil, castor oil, paraffin oil, edible oil group, and any combination thereof ; Surfactants; and an aqueous phase component that is a water-soluble and water-soluble substance, wherein the aqueous phase component is a water-soluble active ingredient that is a water-soluble pigment; and alginate; and hyaluronic acid, wherein the nanoemulsion contains 70% to 80% by weight of the oil phase component based on the total weight of the nanoemulsion, 10% to 20% by weight of the aqueous phase component, and the interface It relates to a technique comprising from 5% to 15% by weight of an active agent.

However, as in the prior art, nanomaterials usually have a size of 1 to 100 nm, and easily penetrate into the skin cell gap, so they are very effective in delivering active ingredients deep into the skin, but they can penetrate into blood vessels and cause side effects to the human body. There is a concern that there is

As a method for making a microemulsion in cosmetics, it can be divided into high-energy methods and low-energy methods. Generally, a high-energy method using a microfluidizer is used. . However, with expensive equipment, it is difficult for small and medium-sized businesses to make products using the equipment, and the manufacturing process is more difficult than the emulsified products using a general HOMO Mixer. On the other hand, when an oil-in-water emulsion is prepared with a HOMO Mixer using a general thickener and emulsifier used in cosmetics, the emulsion has a large particle size of 10 μm or more, and the particle size is not uniform, and is mostly circular. Non-fluid particles having a shape of

Therefore, the present invention has been devised to solve the above problem,

An object of the present invention is to provide an oil-in-water emulsion composition having micro-sized particles using a general homomixer by combining a thickener, a nonionic surfactant, an oil phase component, and the like.

In particular, an object of the present invention is to provide an oil-in-water emulsion composition having fluidity to facilitate penetration into the skin cell gap.

In order to achieve the above object, the fine oil-in-water emulsion composition according to the present invention is

Purified water;

a thickener comprising at least one selected from alkyl acrylate cross polymers;

Nonionic surfactants comprising at least one selected from the group consisting of stearates, ceteares, and olivates;

an oil phase comprising at least one selected from the group consisting of fatty alcohols, fatty acids, silicone oils, ester oils, and vegetable oils;

It is characterized in that the particles have fluidity and have a size of 1 to 3 μm.

As described above, the fine oil-in-water emulsion composition according to the present invention is

The emulsion composition with a particle size of 1-3 μm with micro-unit, more precisely, fluidity facilitates penetration into the skin cell gap, but prevents it from penetrating into the blood vessels, so that the effective effect of the emulsion can be safely and effectively penetrated into the skin without side effects. can do it

In addition, since manufacturing is possible using a homomixer without using a high-pressure emulsifier, the cost of using expensive equipment can be reduced.

1 is a photograph of confirming the particle size of Comparative Examples and Examples according to the present invention;

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

The present invention is intended to be described in detail in the text of the embodiment (態樣, aspect) (or embodiments) can be applied to various changes and can have various forms. However, this is not intended to limit the present invention to the specific disclosed form, it should be understood to include all modifications, equivalents and substitutes included in the spirit and scope of the present invention.

In each drawing, the same reference numerals, particularly the tens digit and the one digit, or the tens digit, the one digit, and the same alphabetic reference numerals indicate members having the same or similar functions, and, unless otherwise specified, each of the figures in the drawings. The member indicated by the reference sign may be understood as a member conforming to these standards.

In addition, in each drawing, components are expressed in exaggeratedly large (or thick) or small (or thin) in size or thickness in consideration of convenience of understanding, or simplified, but the protection scope of the present invention is limited by this. it shouldn't be

The terminology used herein is only used to describe a specific embodiment (aspect, aspect, aspect) (or embodiment), and is not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly dictates otherwise. In the present application, terms such as comprises or consists of are intended to designate that the features, numbers, steps, operations, components, parts, or combinations thereof described in the specification exist, but one or more other features It is to be understood that it does not preclude the possibility of the presence or addition of numbers, steps, operations, components, parts, or combinations thereof.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and should not be interpreted in an ideal or excessively formal meaning unless explicitly defined in the present application. does not

First, the fine oil-in-water emulsion composition having fluidity according to the present invention comprises purified water as a solvent, a thickener, a nonionic surfactant, and an oil phase, and the particles have fluidity and have a size of 1 to 3 μm. characterized.

First, purified water refers to water from which all impurities such as dissolved ions, solid particles, microorganisms, organic matter, and dissolved gases contained in water have been removed.

The thickener is used to increase the adhesiveness, and in the present invention, it is made of one or more selected from alkyl acrylate cross polymers, and more preferably an acrylate/C10-30 alkyl acryl that is not a commonly used carbomer. It is preferable to include a late cross polymer.

Carbomer is an acidic high molecular compound, mainly polymerized with acrylic acid. It is a grade 1 EWG (Environmental Working Group) and is one of the thickeners frequently used in cosmetics.

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is one or more simple esters crosslinked with allylether of sucrose or allylether of pentaerythritol or acrylic acid, methacrylic It is a copolymer of one or more monomers composed of one or more acid and C10-30 alkyl acrylate, and is widely used as a thickener for controlling the viscosity of cosmetics, like the carbomer.

In the present invention, the nonionic surfactant consists of at least one selected from the group consisting of stearate, ceteareth, and olivate, and more preferably glyceryl stearate. Stearate), Ceteareth-20 (Ceteareth-20), Cetearyl Olivate (Cetearyl Olivate), it is preferable to consist of a mixture of sorbitan olivate (Sorbitan Olivate).

In the present invention, the oil phase is made of at least one selected from the group consisting of fatty alcohols, fatty acids, silicone oils, ester oils, and vegetable oils, more preferably cetearyl alcohol, stearic acid acid), ethylhexyl stearate, caprylic/capric triglyceride, and dimethicone.

Furthermore, the present invention comprises 0.05 to 0.3% by weight of a thickener, 1 to 5% by weight of a nonionic surfactant, and 5 to 30% by weight of an oil phase, and the remainder consists of purified water,

More preferably, 0.1 to 0.15 wt% of a thickener, 2.3 to 3 wt% of a nonionic surfactant, and 12.5 wt% of an oil phase are included, and the remainder is preferably made of purified water.

In addition, the present invention further comprises an additive consisting of any one or more of a pH adjuster, a chelating agent, a moisturizing agent, a conditioning agent, a fragrance, a preservative, a vitamin, an extract, and a protein It is also possible to impart a functional effect to the emulsion,

At this time, it is preferable to use a mixture of butylene glycol and glycerin as a moisturizer, and use arginine as a pH adjuster.

Preferably, it is preferably composed of 8% by weight of a moisturizing agent and 0.1 to 0.15% by weight of a pH adjusting agent, but this should not be interpreted as limiting the scope of the right.

[Table 1]

The [Table 1] shows the weight percent of each component relative to the total weight of the emulsion composition, and as shown in FIG. 1, the particle size is to have a uniform particle size of 1-3 μm, but the shape is fluidly deformed (Circle, oval, triangle, pentagon, etc.)

Therefore, due to the particles having fluidity, it is easy to penetrate into the skin gap, and thus, an effect that can penetrate the functional effect into the skin more quickly can be expected.

In addition, as shown in [Table 1] above, the present invention, when using a mixture of glyceryl stearate, ceteareth-20, cetearyl olivate, and sorbitan olivate among nonionic surfactants, the particles exhibit fluidity. You can check that you can have it.

Comparative Examples 1 and 2 were examples in which carbomer was used as a thickener and a mixture of polysorbate 60 and PEG-100 stearate was used as a surfactant. There was no liquidity

As in Comparative Example 3, an acrylate/C10-30 alkyl acrylate crosspolymer was used as a thickener, but it was also found that this also did not show the fluidity of the particles.

On the other hand, as in Examples 1 and 2, when a mixture of glyceryl stearate, ceteareth-20, cetearyl olivate, and sorbitan olivate was used as the nonionic surfactant, the fluidity of the particles was confirmed.

That is, according to the present invention, the fluidity of the particles, that is, the shape of the particles can be deformed, easily pass through the cell gap, and the functional material of the emulsion penetrates the skin, and the effect can be expected.

In addition, in the above description of the present invention, with reference to the accompanying drawings, a fine oil-in-water emulsion composition having a specific shape, structure and composition has been mainly described, but the present invention is capable of various modifications, changes and substitutions by those skilled in the art, and such modifications , changes and substitutions should be construed as falling within the protection scope of the present invention.

A: Emulsion composition

Claims (4)

Purified water;
a thickener comprising at least one selected from alkyl acrylate cross polymers;
Nonionic surfactants comprising at least one selected from the group consisting of stearates, ceteares, and olivates;
an oil phase comprising at least one selected from the group consisting of fatty alcohols, fatty acids, silicone oils, ester oils, and vegetable oils;
is made, including

The particles have fluidity that can be deformed in shape, and the size of the particles produced by a homomixer is 1-3 μm,
The nonionic surfactant consists of a mixture of glyceryl stearate, ceteareth-20, cetearyl olivate, and sorbitan olivate,
The oil phase consists of a mixture of cetearyl alcohol, stearic acid, ethylhexyl stearate, caprylic/capric triglyceride, and dimethicone,
A fine oil-in-water emulsion composition having fluidity, characterized in that the thickener is 0.05 to 0.3% by weight, nonionic surfactant 1 to 5% by weight, oil phase 5 to 30% by weight, and the remainder is purified water. The method of claim 1,
A fine oil-in-water emulsion composition with fluidity comprising 0.1 to 0.15 wt% of a thickener, 2.3 to 3 wt% of a nonionic surfactant, and 12.5 wt% of an oil phase 3. The method according to claim 1 or 2,
Fine oil-in-water emulsion composition with fluidity, characterized in that it further comprises an additive comprising any one or more of a pH adjuster, a chelating agent, a moisturizing agent, a conditioning agent, a fragrance, a preservative, a vitamin, an extract, and a protein 4. The method of claim 3,
A fine oil-in-water emulsion composition having fluidity, characterized in that a mixture of butylene glycol and glycerin is used as a moisturizer and arginine is used as a pH adjuster.

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