KR102240984B1 - Cosmestic composition for blocking ultraviolet lays and blue light using electron beam irradiation and preparation method thereof - Google Patents

Abstract

Disclosed is a composition for blocking ultraviolet rays and blue light including a polystyrene-based polymer subjected to electron beam irradiation. The composition for blocking ultraviolet rays and blue light according to the present invention is non-toxic, has excellent biocompatibility, and has excellent effect of blocking ultraviolet rays and blue light.

Description

Polystyrene-based polymer cosmetic composition for blocking ultraviolet rays and blue light using electron beam irradiation, and a method for manufacturing the same TECHNICAL FIELD OF THE INVENTION

It relates to a polystyrene-based polymer cosmetic composition for blocking ultraviolet rays and blue light using electron beam irradiation, and a method of manufacturing the same.

Sunlight can be classified into ultraviolet rays, visible rays, and infrared rays, and it is widely known that ultraviolet rays can adversely affect the skin. Ultraviolet is a type of electromagnetic wave, depending on the length of the wavelength, UV-A (UV-A, wavelength in the range of 320-400 nm), UV-B (UV-B, wavelength in the range of 290-320 nm), and UV-C (UV -C, wavelength in the range of 200-290 nm).

Among them, UV-A and UV-B pass through the ozone layer to reach the surface and reach the human skin. In the skin, UV rays can have positive effects, such as vitamin synthesis, but can lead to aging, burns, and even skin cancer. In order to prevent the negative effects of UV exposure, UV and blue light blockers are widely used, but commercially available UV and blue light blockers also have problems.

First, UV and blue light blockers can be classified as physical blockers and chemical blockers. There are many studies currently known that both are toxic, and young children, pregnant women, and the elderly should be careful when using UV and blue light blockers.

Therefore, there is a need for research on non-toxic UV and blue light blocking agents.

In addition, blue light is visible light in a wavelength range of 380 nm to 500 nm, and refers to light having the shortest wavelength and strong energy among the light reaching the retina. The wavelength range in the range of nm to 430 nm is also classified as violet light. Little is known about the effect of light (eg, visible light) of other wavelengths other than ultraviolet rays on human skin, but recently, the harmfulness of blue light to the skin has been investigated.

Since blue light is especially included in LED displays and LED lighting such as smartphones, laptops, and monitors, which are essential items of modern people, there is inevitable contact in the living environment of the modern society, so attempts to block it have been made in many ways. It's going on.

Accordingly, the inventors of the present invention developed a non-toxic composition capable of simultaneously blocking UV and blue light while researching to solve the problem of exposure to blue light as well as the seriousness of UV exposure and toxicity of commercially available UV and blue light blocking agents. Excellent UV and blue light blocking performance was confirmed, and the present invention was completed.

Republic of Korea Patent Publication 10-2018-0024903

An object of the present invention is to provide a composition for blocking ultraviolet rays and blue light, which is non-toxic and has improved blocking performance of ultraviolet rays and blue light.

Another object of the present invention is to provide a cosmetic composition for blocking UV and blue light, which is non-toxic and has improved UV and blue light blocking performance.

In order to achieve the above object, the present invention

It provides a composition for blocking ultraviolet rays and blue light (blue light) comprising a polystyrene-based polymer treated with electron beam irradiation.

In addition, the present invention

It provides a method of preparing a composition for blocking ultraviolet rays and blue light, comprising the step of irradiating an electron beam to a polystyrene-based polymer.

Furthermore, the present invention

It provides a cosmetic composition for blocking ultraviolet rays and blue light containing a composition for blocking ultraviolet rays and blue light comprising a polystyrene polymer treated with electron beam irradiation.

In addition, the present invention

It provides a method for expressing ultraviolet and blue light blocking properties in a polymer comprising the step of irradiating an electron beam to a polystyrene-based polymer.

Furthermore, the present invention

It includes the step of irradiating an electron beam to a polystyrene-based polymer, and provides a method of controlling a wavelength region absorbed by the polymer by controlling the irradiation amount of the electron beam to be irradiated.

The composition for blocking ultraviolet rays and blue light according to the present invention is non-toxic, has excellent biocompatibility, and has excellent effects of blocking ultraviolet rays and blue light.

1 is a graph analyzing the compositions of Examples 1 to 4 and Comparative Example 1 by UV-Vis spectroscopy;
2 is a graph analyzing the compositions prepared in Example 1 and Comparative Example 1 by ^{1 H NMR;}
3 is a graph evaluating the phototoxicity of the compositions prepared in Example 1 and Comparative Example 1 according to the OECD TG 432 guideline by 353 NRU PT evaluation;
4 is a graph analyzing the UV blocking performance of sunscreen agents prepared with the compositions prepared in Example 1 and Comparative Example 1. FIG.

The present invention

It provides a composition for blocking ultraviolet rays and blue light comprising a polystyrene-based polymer subjected to electron beam irradiation treatment.

Hereinafter, the composition for blocking ultraviolet rays and blue light according to the present invention will be described in detail.

The composition for blocking ultraviolet rays and blue light according to the present invention comprises a polystyrene-based polymer subjected to electron beam irradiation.

Specifically, the electron beam irradiation treatment may be performed at an irradiation amount of ^{1.0 × 10 12} electrons/cm ² to 1.0 × 10 ²⁰ electrons/cm ^{2 , and 1.0 × 10 15} electrons/cm ² to 1.0 × 10 ¹⁸ electrons/cm ² It can be performed with an irradiation amount of 1.0 × 10 ¹⁶ electrons/cm ² to 3.0 × 10 ¹⁷ electrons/cm ² , and 2.0 × 10 ¹⁶ electrons/cm ² to 2.0 × 10 ¹⁷ electrons/cm ² It may be performed with an irradiation amount of 1.0 × 10 ¹⁷ electrons/cm ² to 2.0 × 10 ¹⁷ electrons/cm ² .

In addition, the polystyrene-based polymer may be in the form of particles, and may be in the form of a powder as an aggregate of polymers in the form of particles.

The particle size of the polystyrene-based polymer is preferably 10 nm to 100 µm, may be 100 nm to 50 µm, 150 nm to 10 µm, and 10 nm to 10 µm. If the particle size of the polymer is out of the above range, there may be a problem of insufficient UV and blue light blocking performance.

The composition for blocking UV and blue light according to the present invention is a non-toxic UV and blue light blocking composition, and is a polymer having excellent biocompatibility in which UV and blue light blocking performance is generated or increased by irradiation with electron beams.

In addition, the present invention

It provides a method of preparing a composition for blocking ultraviolet rays and blue light, comprising the step of irradiating an electron beam to a polystyrene-based polymer.

Hereinafter, a method for preparing a composition for blocking ultraviolet rays and blue light according to the present invention will be described in detail.

The method for preparing a composition for blocking ultraviolet rays and blue light according to the present invention includes the step of irradiating an electron beam to a polystyrene-based polymer.

By irradiating an electron beam to a polystyrene polymer that does not exhibit ultraviolet and blue light blocking performance or a polystyrene polymer having insignificant ultraviolet and blue light blocking performance, ultraviolet and blue light blocking performance can be expressed or improved.

Specifically, the electron beam irradiation may be performed at an irradiation amount of ^{1.0 × 10 12} electrons/cm ² to 1.0 × 10 ²⁰ electrons/cm ^{2 , and 1.0 × 10 15} electrons/cm ² to 1.0 × 10 ¹⁸ electrons/cm ² It can be carried out with an irradiation dose, can be carried out with an irradiation dose of 1.0 × 10 ¹⁵ electrons/cm ² to 3.0 × 10 ¹⁸ , and 1.0 × 10 ¹⁶ electrons/cm ² to 3.0 × 10 ¹⁷ electrons/cm ² It can be carried out with an irradiation amount of ^{2.0 × 10 16} electrons/cm ² to 2.0 × 10 ¹⁷ electrons/cm ^{2 , and 1.0 × 10 17} electrons/cm ² to 2.0 × 10 ¹⁷ electrons/cm ² I can.

Further, the method of preparing the composition for blocking ultraviolet rays and blue light according to the present invention may further include molding a polystyrene polymer into a powder form before irradiation with electron beams. The polystyrene polymer may be in the form of particles, and may be in the form of a powder as an aggregate of polymers in the form of particles.

The polystyrene-based polymer molded in powder form is an aggregate of polymer particles, and the particle size of the polymer is preferably 10 nm to 100 µm, may be 100 nm to 50 µm, 150 nm to 10 µm, and 10 nm It may be in the range of 10 μm. If the particle size of the polymer is out of the above range, there may be a problem of insufficient UV and blue light blocking performance.

In addition, the present invention

It provides a cosmetic composition for blocking ultraviolet rays and blue light containing a composition for blocking ultraviolet rays and blue light comprising a polystyrene polymer treated with electron beam irradiation.

The cosmetic composition for blocking ultraviolet rays and blue light according to the present invention includes the polystyrene polymer treated with electron beam irradiation presented in the present invention as described above, so that it can exhibit biocompatible properties with excellent UV and blue light blocking performance as well as non-toxicity. .

The cosmetic composition may be used as a sunscreen.

In addition, the present invention

It provides a method of expressing ultraviolet and blue light blocking properties in a polymer comprising the step of irradiating an electron beam to a polystyrene-based polymer.

Furthermore, the present invention

It includes the step of irradiating an electron beam to the polystyrene-based polymer, and provides a method of controlling a wavelength region absorbed by the polystyrene-based polymer by adjusting the irradiation amount of the electron beam to be irradiated.

The wavelength region absorbed by the polystyrene-based polymer may range from 200 nm to 600 nm, and may range from 200 nm to 500 nm.

Hereinafter, the present invention will be described in detail by the following examples and experimental examples.

However, the following examples and experimental examples are merely illustrative of the present invention, and the scope of the invention is not limited by the examples and experimental examples.

<Example 1> Preparation 1 of polystyrene particles subjected to electron beam irradiation

A composition for blocking ultraviolet rays and blue light was prepared by irradiating an electron beam of 50 keV energy to a polystyrene (PS) powder having an average particle size of 150 nm at ^{an irradiation amount of 3.0 × 10 16} electrons/cm ² under a vacuum condition of ^{10 -5 Torr.} .

<Example 2> Preparation 2 of polystyrene particles subjected to electron beam irradiation

A composition for blocking ultraviolet rays and blue light was prepared by irradiating an electron beam of 50 keV energy to a polystyrene (PS) powder having an average particle size of 150 nm at ^{an irradiation amount of 6.0 × 10 16} electrons/cm ² under a vacuum condition of ^{10 -5 Torr.} .

<Example 3> Preparation 3 of polystyrene particles subjected to electron beam irradiation

A composition for blocking ultraviolet rays and blue light was prepared by irradiating an electron beam of 50 keV energy to a polystyrene (PS) powder having an average particle size of 150 nm at ^{an irradiation amount of 1.2 × 10 17} electrons/cm ² under a vacuum condition of ^{10 -5 Torr.} .

<Example 4> Preparation 4 of polystyrene particles subjected to electron beam irradiation

A composition for blocking ultraviolet rays and blue light was prepared by irradiating an electron beam of 50 keV energy to a polystyrene (PS) powder having an average particle size of 150 nm at ^{an irradiation amount of 1.8 × 10 17} electrons/cm ² under a vacuum condition of ^{10 -5 Torr.} .

<Comparative Example 1>

Polystyrene (PS) powder having an average particle size of 150 nm was prepared.

<Experimental Example 1> Analysis of UV and blue light blocking performance

In order to confirm the ultraviolet and blue light blocking performance of the ultraviolet and blue light blocking composition according to the present invention, the compositions prepared in Examples 1 to 4 and Comparative Example 1 were subjected to ultraviolet-visible light spectroscopy (UV-Vis). spectroscopy), and the results are shown in FIG. 1.

As shown in FIG. 1, it was confirmed that the UV and blue light blocking composition prepared by irradiating an electron beam to a polystyrene polymer in the form of particles in Examples 1 to 4 had significantly improved UV and blue light blocking properties.

<Experimental Example 2> Analysis of polystyrene particles irradiated with electron beams

In order to confirm the change of the polystyrene particles, which is a composition for blocking ultraviolet rays and blue light according to the present invention, the compositions prepared in Example 1 and Comparative Example 1 ^{were analyzed by 1} H NMR, and the results are shown in FIG. 2.

As shown in FIG. 2, it can be seen that the polystyrene particles of Comparative Example 1 did not have a peak in the 7.5 ppm to 9 ppm region, while the polystyrene particles of Example 1 had a new peak in the 7.25 ppm to 9 ppm region. This is the formation of a polycyclic structure in the polystyrene particles, through which ultraviolet absorption characteristics may be expressed. Specifically, aryl radicals, main chain radicals, and chain-end radicals are generated in polystyrene by electron beam irradiation. This is because the size of the cluster is increased by being bonded to benzene.

<Experimental Example 3> 3T3 NRU PT phototoxicity evaluation result according to OECD TG 432 guideline

The phototoxicity evaluation result of the composition for blocking ultraviolet rays and blue light according to the present invention was confirmed. The composition prepared in Example 1 and Comparative Example 1 was evaluated for 3T3 NRU PT phototoxicity according to the 3OECD TG 432 guideline, and the results are shown in FIG. 3 and Tables 1 and 2 below.

Table 1 is the OECD guideline phototoxicity criteria results, and Table 2 is the 3T3 NRU PT results. 3, Table 1 and Table 2, as a result of the phototoxicity evaluation, the polyesterin particles were classified as having no phototoxicity in both Example 1 and Comparative Example 1.

<Experimental Example 4> Analysis of UV protection index of sunscreen

In order to confirm the UV blocking performance of the UV and blue light blocking composition according to the present invention for actual cosmetic application, a sunscreen agent was prepared using the compositions prepared in Examples 1 to 4 and Comparative Example 1. , Using the prepared sunscreen agent, the UV-blocking index was analyzed using UV-Vis spectroscopy, and the results are shown in FIGS. 4 and 3.

Specifically, the sunscreen was prepared by mixing 25% by weight of each composition and 75% by weight of the base, and the base was prepared by mixing ethanol and distilled water in a weight ratio of 6:4.

In order to analyze the UV blocking index, first, apply a sunscreen as much as ^{1.3 mg/cm 2} to a sample plate (HD6) with a certain roughness suggested by the International Organization for Standardization (ISO). After that, the transmittance spectrum of the HD6 plate to which the sunscreen is applied is analyzed for the UV-blocking index using UV-Vis spectroscopy.

Electron radiation dose (e/cm ² ) SPF in vitro PA ₀ 0 1.8 1.7 3.0 × 10 ¹⁶ 8.1 3.5 6.0 × 10 ¹⁶ 11.0 6.1 1.2 × 10 ¹⁷ 12.8 7.6 1.8 × 10 ¹⁷ 13.6 8.5

(In Table 3 above, SPF is the UVB blocking index, and PA ₀ is the UVA blocking index.

E(λ): erythema action spectrum

P(λ): PPD action spectrum

I(λ): Irradiance in the spectrum obtained from the UVA source

A0(λ): Average of monochromatic absorption of the test product film before UV irradiation

C: correction factor

dλ: wavelength increase (1 nm))

As shown in Tables 3 and 4, it was confirmed that the sunscreen agent including the composition according to the present invention can be applied as a cosmetic for blocking ultraviolet rays and blue light.

As described above, it was confirmed that the composition for blocking ultraviolet rays and blue light according to the present invention is a composition for blocking ultraviolet rays and blue light, and exhibits excellent ultraviolet rays and blue light blocking performance. Accordingly, when applied as an ultraviolet and blue light blocking cosmetic, it is possible to solve the toxicity problem inherent in commercially available ultraviolet and blue light blocking cosmetic, and provide a cosmetic having more excellent ultraviolet and blue light blocking performance.

Claims (10)

Including a polystyrene polymer treated with electron beam irradiation at an irradiation amount of 1.0 × 10 ¹⁶ electrons/cm ² to 3.0 × 10 ¹⁷ electrons/cm ^2,
The polystyrene-based polymer is in the form of particles, the particle size of the polymer is 100 nm to 10 ㎛, UV and blue light (blue light) blocking composition.
delete delete delete Blocking ultraviolet rays and blue light including the step of irradiating a polystyrene polymer having a particle size of 100 nm to 10 µm with ^{an irradiation amount of 1.0 × 10 16} electrons/cm ² to 3.0 × 10 ¹⁷ electrons/cm ² Method for producing a composition for use.
delete delete 1.0 × 10 ¹⁶ electrons/cm ² to 3.0 × 10 ¹⁷ electrons/cm ² containing a polystyrene polymer treated with electron beam irradiation at an irradiation amount, the polystyrene polymer is in the form of particles, the particle size of the polymer is 100 nm to 10 A cosmetic composition for blocking ultraviolet rays and blue light containing a composition for blocking ultraviolet rays and blue light of µm.
Ultraviolet and blue light to a polymer comprising the step of irradiating an electron beam to a polystyrene polymer having a particle size of 100 nm to 10 µm at ^{an irradiation amount of 1.0 × 10 16} electrons/cm ² to 3.0 × 10 ¹⁷ electrons/cm ² A method of expressing light blocking properties.
Including the step of irradiating an electron beam to a polystyrene polymer having a particle size of 100 nm to 10 µm at ^{an irradiation amount of 1.0 × 10 16} electrons/cm ² to 3.0 × 10 ¹⁷ electrons/cm ^{2, and} A method of controlling the wavelength range absorbed by the polystyrene-based polymer by adjusting the irradiation amount.

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