KR102232947B1 - Clot removal device and clot removal method using the same - Google Patents

Abstract

The present application relates to a device for removing a blood clot, and the blood clot removal device according to an aspect of the present application includes at least two first segments arranged along a length direction of the device and the at least two first segments. A first body including at least one first mouth structure disposed between two adjacent first segments in a longitudinal direction; A second body including at least one second segment corresponding to the at least one mouse structure; A first pull wire operably connected to the first body; And a second full wire operably connected to the second body, wherein the first body and the second body at least partially overlap along the length direction, and one of the first body and the second body Is movable with respect to the other one of the first body and the second body, and the second segment opens or closes the first mouse structure due to a relative movement between the first body and the second body.

Description

Blood clot removal device and blood clot removal method using the same {CLOT REMOVAL DEVICE AND CLOT REMOVAL METHOD USING THE SAME}

The present application relates to a blood clot removal device and a blood clot removal method using the same.

Vascular disease can be divided into ischemic vascular disease caused by blockage of blood vessels and hemorrhagic vascular disease caused by bursting of blood vessels. Among them, in ischemic vascular disease, blood clots are removed from the blood vessels of the patient for treatment because blood vessels are obstructed or strong strictures occur in the blood vessels, thereby reducing blood flow, thereby necrosis of vascular tissues. In the past, dissolving blood clots by injecting a thrombolytic agent into a vein was a typical treatment method, but recently, a blood clot removal device that mechanically removes blood clots from blood vessels, such as a stent retriever, has emerged.

The stent retriever is a treatment method that restores blood flow by physically removing blood clots from blood vessels. After the user inserts a stent retriever into the patient's blood vessel and expands it, when the expanded device is integrated with the blood clot, the user can pull the device to remove the blood clot from the blood vessel.

However, blood clots located in the patient's blood vessels vary in size and hardness, and current stent retrievers cannot capture them in one pass, so they may have to pass through the blood vessels repeatedly, resulting in damage to the blood vessel wall and reperfusion. There is a problem of increasing the time required for the procedure.

One problem to be solved in the present specification is to provide a blood clot removal device capable of removing a blood clot in one pass, and a blood clot removal method using the same.

One problem to be solved in the present specification is to provide a blood clot removal device that provides improved visibility to a user and a blood clot removal method using the same.

One problem to be solved in the present specification is to provide a blood clot removal device capable of removing both lead and menstrual blood clots, and a blood clot removal method using the same.

The problem to be solved in the present specification is not limited to the above-described problem, and the problems that are not mentioned will be clearly understood by those of ordinary skill in the technical field to which the present invention belongs from the present specification and the accompanying drawings. .

According to an aspect of the present specification, in a device for removing a blood clot, at least two first segments arranged along a length direction of the device and two first segments adjacent in the length direction of the at least two first segments A first body including at least one first mouse structure disposed therebetween; A second body including at least one second segment corresponding to the at least one mouse structure; A first pull wire operably connected to the first body; And a second full wire operably connected to the second body, wherein the first body and the second body at least partially overlap along the length direction, and one of the first body and the second body Is movable with respect to the other one of the first body and the second body, and the second segment opens or closes the first mouse structure due to a relative movement between the first body and the second body Can be provided.

According to an aspect of the present specification, in an apparatus for removing a blood clot, a stent body including a base body and a moving body-the base body comprises two first segments and a mouse structure disposed between the two first segments. And the moving body includes a second segment slidably disposed within the base body; And a first pull wire connected to the moving body and configured to move the moving body from a first position to a second position. In the first position, the second segment is disposed to correspond to the mouse structure, and the second In the position, the second segment is arranged to correspond to one of the two first segments.-A device including; may be provided.

According to an aspect of the present specification, in an apparatus for removing blood clots, a strut framework including a first strut framework and a second strut framework-the first strut framework is a first tubular body, the first tubular body A second tubular body positioned distal to the body and a first mouth structure disposed between the first tubular body and the second tubular body, wherein the second strut framework includes a third tubular body- ; A first pull wire operably connected to the first strut framework; A second pull wire operably connected to the second strut framework; And a locking structure for coupling or decoupling the first pull wire and the second pull wire, wherein when the locking structure decouples the first pull wire and the second pull wire, the first strut frame One of the work and the second strut framework may be moved relative to the other, and the third tubular body may open or close the first mouse structure by the relative movement.

According to an aspect of the present specification, there is provided an apparatus for removing a blood clot, comprising: a first pull wire; A second pull wire; And a first strut framework connected to the first pull wire and a second strut framework connected to the second pull wire.- The first strut framework and the second strut framework include a plurality of cells. Includes at least one thrombus inlet part including a plurality of thrombus coupling portions including a bridge and a bridge connecting one of the plurality of thrombus coupling portions with another thrombus coupling portion adjacent thereto, but including, the first strut frame When the thrombus coupling part of the work and the thrombus coupling part of the second strut framework are arranged so as to cross each other, the strut framework has a tube shape closed in the circumferential direction, and the at least one thrombus of the first strut framework When the inlet portion and the at least one thrombus inlet portion of the second strut framework are arranged to correspond to each other, the strut framework may be provided with a device having a tube shape open in a circumferential direction.

According to an aspect of the present specification, there is provided an apparatus for removing a blood clot, comprising: a pull wire; And a body connected to the full wire and having an arrangement state and a delivery state, the body including a first body including a first inflow region and a first coupling region and a second body including a second coupling region; Including, wherein, when the device is in an arrangement state, the arrangement of the body is an open arrangement in which the second coupling region overlaps the first coupling region and a closed arrangement in which the second coupling region overlaps the first inlet region Including, when the device is in a delivery state, the body may be compressed from the closed arrangement to reduce the local maximum radial force applied to the catheter surrounding the body from the body may be provided.

According to an aspect of the present specification, there is provided an apparatus for removing a blood clot, comprising: a first framework formed by a strut and including an engaging region and an inlet region; and a second framework formed by the strut and including an engaging region A self-expandable body, wherein the binding region includes a cell structure for binding blood clots, and the inlet region includes a mouse structure for introducing blood clots, wherein the self-expandable body includes the first framework. And performing a shape change between a closed arrangement and an open arrangement according to a positional relationship of the second framework, wherein the open arrangement allows the self-expandable body to capture blood clots into the interior of the self-expandable body. In the closed arrangement, a device may be provided that allows the self-expandable body to engage with a blood clot through the entire length of the self-expandable body.

According to an aspect of the present specification, in a method for removing a blood clot, the step of arranging a blood clot removal device including a first body and a second body and having a first arrangement in a target area in which the blood clot is predicted to be located -The first arrangement corresponds to a first positional relationship between the first body and the second body -; Determining an arrangement of the blood clot removal device to maintain the arrangement of the blood clot removal device as the first arrangement or to change to a second arrangement different from the first arrangement-the second arrangement is a second arrangement different from the first positional relationship 2 corresponds to a positional relationship, and the second positional relationship is a positional relationship in which one of the first body and the second body has moved in a proximal direction or a distal direction with respect to the other in the first positional relationship; And recovering the blood clot removing device from the target area.

The solution means of the subject of the present specification is not limited to the above-described solution means, and solutions that are not mentioned will be clearly understood by those of ordinary skill in the technical field to which the present invention pertains from the present specification and the accompanying drawings. I will be able to.

According to an exemplary embodiment of the present specification, a blood clot can be effectively removed by using a blood clot removal device capable of changing the arrangement.

According to the exemplary embodiment of the present specification, a blood clot can be effectively removed by using a blood clot removal device capable of changing whether or not an open invitation is formed.

According to the exemplary embodiment of the present specification, a blood clot can be effectively removed by using a blood clot removal device capable of changing a radius.

According to the exemplary embodiment of the present specification, a blood clot removal device capable of converting between a preliminary thrombosis removal mode and a menstrual thrombosis removal mode may be used to remove both the thrombosis and the menstrual thrombosis in one procedure.

The effects of the present invention are not limited to the above-described effects, and effects that are not mentioned will be clearly understood by those of ordinary skill in the art from the present specification and the accompanying drawings.

1 and 2 are diagrams of a conventional apparatus for removing blood clots and a method for removing blood clots.
3 and 4 are diagrams of an example of a blood clot removal device according to an embodiment of the present specification.
5 and 6 are diagrams illustrating removal of a blood clot according to the formation of an open invitation according to an exemplary embodiment of the present specification.
7 is a diagram of a segment and a structure of a mouse of a device for removing blood clots according to an exemplary embodiment of the present specification.
8 is a diagram of a bridge of a blood clot removal device according to an embodiment of the present specification.
9 is a view of a pull wire of the blood clot removal device according to an embodiment of the present specification.
10 is a view of a pull wire disposed inside the pull tube according to an embodiment of the present specification.
11 is a diagram illustrating a stopper of a blood clot removing device according to an exemplary embodiment of the present specification.
12 is a diagram illustrating a locking structure of a blood clot removing device according to an exemplary embodiment of the present specification.
13 is a diagram illustrating a basket of a blood clot removing device according to an exemplary embodiment of the present specification.
14 is a diagram illustrating a connection between a body and a basket of a blood clot removal device according to an exemplary embodiment of the present specification.
15 is a diagram illustrating a size of an open invitation according to a basket of a blood clot removal device according to an exemplary embodiment of the present specification.
16 is a diagram illustrating a basket including a marker of a blood clot removal device according to an exemplary embodiment of the present specification.
17 and 18 are diagrams of an anti-stretch wire of an apparatus for removing blood clots according to an exemplary embodiment of the present specification.
19 is a diagram of an anti-stretch strut and an anti-stretch cell of a blood clot removal device according to an embodiment of the present specification.
20 is a diagram illustrating an example of a wire structure of a blood clot removal device according to an embodiment of the present specification.
21 is a diagram illustrating another example of a wire structure of a blood clot removing device according to an exemplary embodiment of the present specification.
22 is a flowchart illustrating an example of a method of manufacturing a blood clot removing device according to an embodiment of the present specification.
23 is a diagram illustrating formation of a one-dimensional pattern using a fixture according to an exemplary embodiment of the present specification.
24 is a diagram illustrating formation of a two-dimensional pattern using a fixture according to an exemplary embodiment of the present specification.
25 is a diagram illustrating an extension direction of a wire of a two-dimensional pattern according to an exemplary embodiment of the present specification.
26 is a diagram of a two-dimensional pattern formed of a plurality of wires according to an exemplary embodiment of the present specification.
27 is a diagram illustrating formation of a 3D pattern using a fixture according to an exemplary embodiment of the present specification.
28 is a diagram illustrating a connection of wires of a blood clot removal device according to an exemplary embodiment of the present specification.
29 is a flowchart illustrating another example of a method of manufacturing a blood clot removing device according to an embodiment of the present specification.
30 is a diagram illustrating a method of manufacturing a body using a sheet according to an embodiment of the present specification.
31 is a flowchart of another example of a method of manufacturing a blood clot removing device according to an embodiment of the present specification.
32 is a flowchart of a method for removing a blood clot according to an embodiment of the present specification.
33 is a flowchart illustrating an example of a method for removing a blood clot according to an embodiment of the present specification.
34 and 35 are diagrams illustrating another example of a blood clot removal device according to an embodiment of the present specification.
36 is a diagram of another example of a blood clot removing device according to an embodiment of the present specification.
37 is a diagram illustrating another example of a blood clot removing device according to an embodiment of the present specification.
38 is a diagram of a segment of a blood clot removal device according to an embodiment of the present specification and a length of a structure of a mouse.
39 is a diagram of a length according to a position of a segment of a blood clot removal device according to an exemplary embodiment of the present specification.
40 is a diagram illustrating a modified example of a bridge of a blood clot removal device according to an embodiment of the present specification.
41 is a diagram illustrating another modified example of a bridge of a blood clot removal device according to an embodiment of the present specification.
42 is a diagram illustrating a tapering of a body of a blood clot removal device according to an exemplary embodiment of the present specification.
43 to 45 are diagrams illustrating a modification of a blood clot removal device according to an embodiment of the present specification.
46 and 47 are diagrams illustrating the number of times a blood clot removing device according to an embodiment of the present specification.
48 to 52 are diagrams of various embodiments of an apparatus for removing blood clots.

The embodiments described in the present specification are intended to clearly explain the spirit of the present invention to those of ordinary skill in the technical field to which the present invention pertains, so the present invention is not limited by the embodiments described herein, and the present invention The scope of should be construed as including modifications or variations that do not depart from the spirit of the present invention.

The terms used in this specification have been selected as general terms currently widely used in consideration of functions in the present invention, but this varies according to the intention, custom, or the emergence of new technologies of those of ordinary skill in the technical field to which the present invention belongs. I can. However, if a specific term is defined and used in an arbitrary meaning unlike this, the meaning of the term will be separately described. Therefore, the terms used in the present specification should be interpreted based on the actual meaning of the term and the entire contents of the present specification, not a simple name of the term.

The drawings attached to the present specification are for easy explanation of the present invention, and the shapes shown in the drawings may be exaggerated and displayed as necessary to aid understanding of the present invention, so the present invention is not limited by the drawings.

In the present specification, when it is determined that a detailed description of a well-known configuration or function related to the present invention may obscure the subject matter of the present invention, a detailed description thereof will be omitted as necessary. In addition, numbers (eg, first, second, etc.) used in the description of the present specification are merely identification symbols for distinguishing one component from other components.

According to an aspect of the present specification, in a device for removing a blood clot, at least two first segments arranged along a length direction of the device and two first segments adjacent in the length direction of the at least two first segments A first body including at least one first mouse structure disposed therebetween; A second body including at least one second segment corresponding to the at least one mouse structure; A first pull wire operably connected to the first body; And a second full wire operably connected to the second body, wherein the first body and the second body at least partially overlap along the length direction, and one of the first body and the second body Is movable with respect to the other one of the first body and the second body, and the second segment opens or closes the first mouse structure due to a relative movement between the first body and the second body. A removal device may be provided.

Here, a hollow is formed inside one of the first pull wire and the second pull wire, and at least a portion of the other one of the first pull wire and the second pull wire may be disposed inside the hollow. have.

Here, the blood clot removal device, the first pull wire and the second pull wire so as to contact the distal end of one of the first pull wire and the second pull wire when the second segment opens the first mouth structure. It may further include a; stopper formed in the distal region of the other one of the pull wire.

Here, the blood clot removal device further includes a locking structure connected to a proximal end portion of at least one of the first pull wire and the second pull wire, wherein the locking structure includes the first pull wire and the second pull wire. A first state allowing relative movement between pull wires and a second state limiting relative movement between the first pull wire and the second pull wire may be included.

Here, the distal end portion of the segment positioned proximal among the at least two first segments may be formed to extend outwardly of the device and extend along a distal direction.

Here, the proximal end portion of the second segment may be formed to be constricted to the inside of the device and extend along a proximal direction.

Here, each of the first body and the second body may include a proximal end portion tapered toward a circumferential surface direction of the device as it extends in a proximal direction.

Here, each of the first body and the second body may include a proximal end portion tapered toward a central axis direction of the device as it extends in a proximal direction.

Here, the first mouse structure may include a bridge connecting the at least two first segments.

Here, the bridge may connect a distal end portion of a segment positioned proximal among the at least two first segments and a proximal end portion of a segment positioned distal among the at least two first segments.

Here, the thrombus removal device includes a front end of a segment located at a distal of the at least two first segments and a rear end connected at a proximal region of the segment located at a proximal position of the at least two first segments and a potential coupling point. It may further include an anti-stretch wire connected at the distal region and the rear coupling point and extending along the bridge.

Here, the length of the anti-stretch wire may be longer than a distance between the front coupling point and the rear coupling point.

Here, the first segment and the second segment may each include a plurality of first cells and second cells.

Here, the first cell includes a first anti-stretch cell provided with a first anti-stretch strut, and the second cell includes a second anti-stretch cell provided with a second anti-stretch strut. have.

Here, the first cell and the second cell may be provided so as to be displaced from each other when the second segment opens the first mouse structure.

Here, a basket connected to the distal end portion of the first body; may further include.

Here, at least one of the first body and the second body may include a radiopaque material.

Here, the length of the segment located at the most recent of the at least two first segments may be longer than the length of the remaining first segments.

Here, the length of the first mouse structure may be longer than the length of the second segment.

Here, when the blood clot removing device in which the second segment closes the first mouse structure is bent, at least a portion of the second segment may protrude outward from the circumferential surface of the first mouse structure.

According to an aspect of the present specification, in an apparatus for removing a blood clot, a stent body including a base body and a moving body-the base body comprises two first segments and a mouse structure disposed between the two first segments. And the moving body includes a second segment slidably disposed within the base body; And a first pull wire connected to the moving body and configured to move the moving body from a first position to a second position. In the first position, the second segment is disposed to correspond to the mouse structure, and the second In the position, the second segment is disposed to correspond to one of the two first segments. A blood clot removal device including; may be provided.

Here, an interference reduction structure for reducing interference related to the sliding may be formed at at least one of a distal end portion of a proximal segment of the two first segments and a proximal end portion of the second segment.

Here, the interference reduction structure formed at the distal end portion of the proximal segment among the two first segments is formed to extend outwardly of the device and extend in a distal direction, and interference formed at the proximal end portion of the second segment The reduction structure may be formed to shrink inward of the device and extend along the proximal direction.

Here, a second full wire connected to the base body; may further include.

Here, a hollow is formed inside one of the first pull wire and the second pull wire, and at least a portion of the other one of the first pull wire and the second pull wire may be disposed inside the hollow. have.

Here, the blood clot removal device, in the second position to contact the distal end of one of the first pull wire and the second pull wire in the other distal region of the first pull wire and the second pull wire It may further include a; stopper formed.

Here, the blood clot removal device further includes a locking structure connected to a proximal end portion of at least one of the first pull wire and the second pull wire, wherein the locking structure includes the first pull wire and the second pull wire. A first state allowing relative movement between pull wires and a second state limiting relative movement between the first pull wire and the second pull wire may be included.

Here, each of the base body and the moving body may include a proximal end portion tapered toward a circumferential surface direction of the device as it extends in a proximal direction.

Here, each of the base body and the moving body may include a proximal end portion tapered toward a central axis direction of the device as it extends in a proximal direction.

Here, the mouse structure may include a bridge connecting the two first segments.

Here, the bridge may connect a distal end portion of a segment positioned proximal among the two first segments and a proximal end portion of a segment positioned distal among the two first segments.

Here, in the thrombus removal device, a front end is connected at a proximal region of a segment located at a proximal position among the two first segments and a distal coupling point, and a rear end is a distal region of a segment located at a distal end of the two first segments. And an anti-stretch wire connected at the rear coupling point and extending along the bridge.

Here, the length of the anti-stretch wire may be longer than a distance between the front coupling point and the rear coupling point.

Here, the first segment and the second segment may each include a plurality of first cells and second cells.

Here, the first cell includes a first anti-stretch cell provided with a first anti-stretch strut, and the second cell includes a second anti-stretch cell provided with a second anti-stretch strut. have.

Here, the first cell and the second cell may be provided so as to be displaced from each other at the second position.

Here, a basket connected to the distal end portion of the base body; may further include.

Here, at least one of the base body and the moving body may include a radiopaque material.

Here, the length of the proximal segment among the two first segments may be longer than the length of the other first segment.

Here, the length of the mouse structure may be longer than the length of the second segment.

Here, when the blood clot removing device including the moving body located at the first position is bent, at least a portion of the second segment may protrude outward from the circumferential surface of the mouse structure.

According to an aspect of the present specification, in an apparatus for removing blood clots, a strut framework including a first strut framework and a second strut framework-the first strut framework is a first tubular body, the first tubular body A second tubular body positioned distal to the body and a first mouth structure disposed between the first tubular body and the second tubular body, wherein the second strut framework includes a third tubular body- ; A first pull wire operably connected to the first strut framework; A second pull wire operably connected to the second strut framework; And a locking structure for coupling or decoupling the first pull wire and the second pull wire, wherein when the locking structure decouples the first pull wire and the second pull wire, the first strut frame One of the work and the second strut framework may be moved relative to the other, and the third tubular body may open or close the first mouse structure by the relative movement.

Here, when the locking structure couples the first pull wire and the second pull wire, the first strut framework and the second strut framework have the third tubular body opening the first mouse structure. Or they can stay closed and move together.

Here, the second strut framework further includes a fourth tubular body positioned distal to the third tubular body, and a second mouth structure disposed between the third tubular body and the fourth tubular body, The first mouth structure includes a first bridge connecting the first tubular body and the second tubular body, and the second mouth structure includes a second bridge connecting the third tubular body and the fourth tubular body. And both the first bridge and the second bridge may be positioned on an imaginary line substantially parallel to the longitudinal axis of the strut framework and disposed on the circumferential surface of the strut framework.

Here, the blood clot removing device may further include a rotation preventing structure for preventing relative rotation between the first pull wire and the second pull wire.

Here, one of the first pull wire and the second pull wire is a first wire having a hollow cylindrical shape, and the other one of the first pull wire and the second pull wire is at least partially inserted into the first wire. It may be a second wire.

Here, the second wire includes a distal portion, a proximal portion, and a stopper disposed between the distal portion and the proximal portion and preventing the distal portion from being inserted into the first wire, and the third tubular body includes the first mouse structure and When positioned correspondingly, the distance between the stopper from the distal end of the first wire may correspond to the length of the first mouth structure.

Here, the distal end portion of the first tubular body may be formed to extend outwardly of the device and extend in a distal direction.

Here, the proximal end portion of the third tubular body may be formed to be constricted to the inside of the device and extend along a proximal direction.

Here, the strut framework may include a proximal end portion tapered toward a circumferential surface direction of the device as it extends in a proximal direction.

Here, the strut framework may include a proximal end portion tapered toward a central axis direction of the device as it extends in a proximal direction.

Here, the first mouth structure may include a bridge connecting the first tubular body and the second tubular body.

Here, in the blood clot removal device, a front end is connected at a proximal region of the first tubular body and a potential coupling point, and a rear end is connected at a distal region and a rear coupling point of the second tubular body, and extends along the bridge. It may further include an anti-stretch wire.

Here, the length of the anti-stretch wire may be longer than a distance between the front coupling point and the rear coupling point.

Here, when the locking structure coupling the first pull wire and the second pull wire is bent so that the third tubular body closes the first mouth structure, the third tubular body At least a portion may protrude outward from the circumferential surface of the first mouth structure.

According to an aspect of the present specification, there is provided an apparatus for removing a blood clot, comprising: a first pull wire; A second pull wire; And a first strut framework connected to the first pull wire and a second strut framework connected to the second pull wire.- The first strut framework and the second strut framework include a plurality of cells. Includes at least one thrombus inlet part including a plurality of thrombus coupling portions including a bridge and a bridge connecting one of the plurality of thrombus coupling portions with another thrombus coupling portion adjacent thereto, but including, the first strut frame When the thrombus coupling part of the work and the thrombus coupling part of the second strut framework are arranged so as to cross each other, the strut framework has a tube shape closed in the circumferential direction, and the at least one thrombus of the first strut framework When the inlet portion and the at least one thrombus inlet portion of the second strut framework are arranged to correspond to each other, the strut framework may be provided with a device having a tube shape open in a circumferential direction.

According to an aspect of the present specification, there is provided an apparatus for removing a blood clot, comprising: a pull wire; And a body connected to the full wire and having an arrangement state and a delivery state, the body including a first body including a first inflow region and a first coupling region and a second body including a second coupling region; Including, wherein, when the device is in an arrangement state, the arrangement of the body is an open arrangement in which the second coupling region overlaps the first coupling region and a closed arrangement in which the second coupling region overlaps the first inlet region Including, when the device is in a delivery state, the body may be compressed from the closed arrangement to reduce the local maximum radial force applied to the catheter surrounding the body from the body may be provided.

According to an aspect of the present specification, there is provided an apparatus for removing a blood clot, comprising: a first framework formed by a strut and including an engaging region and an inlet region; and a second framework formed by the strut and including an engaging region A self-expandable body, wherein the binding region includes a cell structure for binding blood clots, and the inlet region includes a mouse structure for introducing blood clots, wherein the self-expandable body includes the first framework. And performing a shape change between a closed arrangement and an open arrangement according to a positional relationship of the second framework, wherein the open arrangement allows the self-expandable body to capture blood clots into the interior of the self-expandable body. In the closed arrangement, a device may be provided that allows the self-expandable body to engage with a blood clot through the entire length of the self-expandable body.

According to an aspect of the present specification, in a method for removing a blood clot, the step of arranging a blood clot removal device including a first body and a second body and having a first arrangement in a target area in which the blood clot is predicted to be located -The first arrangement corresponds to a first positional relationship between the first body and the second body -; Determining an arrangement of the blood clot removal device to maintain the arrangement of the blood clot removal device as the first arrangement or to change to a second arrangement different from the first arrangement-the second arrangement is a second arrangement different from the first positional relationship 2 corresponds to a positional relationship, and the second positional relationship is a positional relationship in which one of the first body and the second body has moved in a proximal direction or a distal direction with respect to the other in the first positional relationship; And recovering the blood clot removing device from the target area.

Here, the first arrangement may be a closed arrangement in which an open invitation, which is an area into which the blood clot flows into the blood clot removal device, is not formed, and the second arrangement may be an open arrangement in which the open invitation is formed. .

Here, the blood clot removal device further includes a full wire connected to a moving body that is one of the first body and the second body, and the determining step includes moving the moving body to move the blood clot. The arrangement of the removal devices may be changed from the first arrangement to the second arrangement.

Here, the blood clot removal method further includes determining a characteristic of the blood clot based on a shape of the blood clot removal device, and the determining step comprises: determining an arrangement of the blood clot removal device based on the characteristic. It is possible to determine whether to keep the first arrangement or change to the second arrangement.

Here, the characteristic may include a first characteristic corresponding to a preliminary thrombosis and a second characteristic corresponding to a menstrual thrombosis.

Here, at least one of the first body and the second body may include a radiopaque material.

Here, the arranging may include a push-and-fluff operation that repeatedly moves at least one of the first body and the second body in a distal direction and a proximal direction in order to increase the coupling of the blood clot removal device with the blood clot. It may include the step of performing.

Here, when the arrangement of the blood clot removal device is changed to the second arrangement, the recovering step is after changing the arrangement of the blood clot removal device from the second arrangement to the first arrangement before recovering the blood clot removal device. The blood clot removal device may be recovered.

In the present specification, the blood clot removal device may refer to a device for recovering blood flow by mechanically removing a blood clot to the outside of a blood vessel, such as a stent retriever or a mechanical thrombectomy device.

In the present specification, a thrombus mainly refers to an obstructive thrombus blocking a blood vessel, but is not limited thereto. In addition, in the present specification, blood clots are referred to as soft clots and hard clots. Here, the distinction between limbus and acupuncture points may be classified according to the hardness of the thrombosis. However, it is not strictly possible to classify a thrombus into a percutaneous thrombosis and a menstrual thrombosis based on a specific critical hardening. Therefore, the classification of blood clots in the present specification may be somewhat arbitrary, but for convenience of explanation, the blood clots are classified into two types of blood clots and acupuncture points. For example, in the present specification, at least a part of the blood clot removal device penetrates into the blood clot by the radial force when the blood clot removal device expands (for example, when self-expansion). It means a blood clot having a degree of stiffness that can be engaged with each other, and a menstrual blood clot may mean a blood clot having a degree of firmness that cannot be combined with each other because a blood clot removal device cannot penetrate into the blood clot.

Hereinafter, prior to describing a blood clot removal device and a blood clot removal method according to an embodiment of the present specification, a conventional blood clot removal device and a blood clot removal method will be described.

1 and 2 are diagrams of a conventional apparatus for removing blood clots and a method for removing blood clots.

As shown in FIG. 1, the conventional blood clot removal device 100 is generally configured as a single body. In general, the conventional blood clot removal device 100 may remove blood clots in blood vessels through a body composed of cells mainly formed of struts made of a shape memory alloy material. Referring to FIG. 2, the blood clot removal device 200 is located in an area where the blood clot 202 in the blood vessel 201 is located (hereinafter referred to as "target area") in order to remove the blood clot 202 blocking the blood vessel 201. Will be inserted and placed. In general, the conventional blood clot removal device 200 is composed of a cell having a size smaller than that of a blood clot in order to increase the binding force with the blood clot. Accordingly, in the case of a blood clot, it can be removed outside the blood vessel by being combined with a blood clot removal device. On the other hand, in the case of acupuncture points, it cannot be removed from the outside because it cannot be combined with a blood clot removal device and cannot be captured inside the blood clot removal device. Although not shown in FIG. 2, some blood clot removal devices include large-sized cells capable of capturing blood clots into the device. However, in this case, there is a disadvantage in that the binding force with the blood clot decreases. In other words, the conventional thrombus removal device has a problem in that it is difficult to effectively remove both conjunctival and acupuncture points.

Hereinafter, a blood clot removal device according to an embodiment of the present specification and a blood clot removal method using the same will be described. In this specification, a device for removing blood clots that block human cerebrovascular blood vessels is mainly described, but is not limited thereto, and can be applied to removing blood clots that block other blood vessels such as human cardiovascular or leg blood vessels, and blood vessels of animals other than humans. It could also be applied to remove blood clots that block blood clots.

The blood clot removal device according to the exemplary embodiment of the present specification may have a tube shape that is elongated in one direction and has an empty inside. The blood clot removal device may be disposed in the blood vessel such that its longitudinal direction follows the extension direction of the blood vessel.

The blood clot removal device according to an embodiment of the present specification may be formed by one or more struts. Alternatively, the blood clot removal device may include one or more cells formed by struts.

The shape of the cell can be appropriately designed in consideration of the radial force of the blood clot removal device. As a non-limiting example, the shape of the cell may be a curved rhombus shape or a curved hexagonal shape.

The size of the cell may be appropriately designed in consideration of the radial force of the blood clot removal device. For example, as the size of the cell is smaller, the radial force of the blood clot removal device may increase. The binding of the blood clot removal device to the blood clot according to an embodiment may depend on the size of the cell. For example, as the size of the cell is smaller, the radial force of the blood clot removal device increases, so that the blood clot removal device can penetrate into the blood clot well, and accordingly, the coupling of the blood clot removal device to the blood clot may increase. As another example, as the size of the cell is smaller, the length/area of the strut that can be combined with the thrombus increases, so that the binding of the thrombus removal device to the thrombus may increase.

The cell may comprise a plurality of ends. For example, the cell may comprise at least one of a proximal end, a distal end, an upper end and a lower end. Ends that meet or are connected to adjacent cells may be referred to as junctions.

The blood clot removal device according to the exemplary embodiment of the present specification may include an open area through which a blood clot may flow into or be trapped in the blood clot removal device. Here, the open area may be an area including a cell having a size larger than that of other cells of the blood clot removal device. The open area may be formed on the circumferential surface of the blood clot removal device, but is not limited thereto. In the present specification, an area formed in the blood clot removal device to capture the blood clot into the inside of the blood clot removal device is referred to as an open invitation.

The blood clot removal device according to the exemplary embodiment of the present specification may have a plurality of configurations. For example, the blood clot removal device may have a first arrangement for removing a lead thrombosis and a second arrangement for removing a menstrual thrombosis. Here, the first arrangement and the second arrangement means that it is not possible to remove only the thrombosis and acupoint thrombosis, respectively, but it is more advantageous in removing any one type of thrombosis among the thrombosis and the acupoint. According to an embodiment, the blood clot removal device may further have a third arrangement different from the first arrangement and the second arrangement.

Depending on the arrangement of the blood clot removal device, whether the blood clot removal device includes an open invitation may vary. 3 and 4 are diagrams of an example of a blood clot removal device according to an embodiment of the present specification. Comparing FIGS. 3 and 4, the blood clot removal device 1000 having the arrangement as shown in FIG. 4 includes open invitations 1100a and 1100b, whereas the blood clot removal device 1000 having the arrangement shown in FIG. 3 is You can see it doesn't include an open invitation. Hereinafter, an arrangement in which the open invitation is formed is referred to as an open configuration, and an arrangement in which the open invitation is formed is referred to as a closed configuration. Accordingly, the blood clot removal device 1000 of FIG. 3 has a closed arrangement and the blood clot removal device 1000 of FIG. 4 has an open arrangement. According to an embodiment, the blood clot removal device may further have a partially open arrangement different from the closed arrangement and the open arrangement. In the case of the partially open arrangement, an open invitation having a size smaller than the open invitation formed in the case of the open arrangement may be formed in the blood clot removal device.

The arrangement advantageous for removing the strep thrombosis and the arrangement advantageous for removing a menstrual thrombosis may be different. For example, when the thrombus removing device has a first arrangement, it may be advantageous to remove a strep thrombosis, and when it has a second arrangement, it may be advantageous to remove a menstrual thrombosis. Here, a blood clot removal device having an arrangement advantageous for removing a cleft thrombosis may not include an open invitation, and a blood clot removal device having an arrangement advantageous for removing a menstrual thrombosis may include an open invitation.

5 and 6 are diagrams illustrating removal of a blood clot according to the formation of an open invitation according to an exemplary embodiment of the present specification.

Referring to FIG. 5, the apparatus 1000 for removing blood clots having a closed arrangement may be advantageous for removing the blood clot 203. As described above, the blood clot 203 may be removed by the thrombus removal device 1000 or the strut dig into the thrombus 203 and bond with each other, and then recover the thrombus removal device 1000 to the outside of the blood vessel 201. . In the case of the blood clot removing device 1000 having an open arrangement, since it cannot be combined with a blood clot in the open invitation, it may be disadvantageous in removing the blood clot 203 compared to the blood clot removing device 1000 having a closed arrangement.

Referring to FIG. 6, the blood clot removal device 1000 having an open arrangement may be advantageous for removing the menstrual blood clot 204. As described above, the menstrual blood clot 204 cannot be removed through a combination unlike the blood clot because the blood clot removal device 1000 or the strut cannot penetrate into the blood clot 204. In the case of the blood clot removal device 1000 having an open arrangement, the blood clot removal device 1000 includes an open invitation, and thus the menstrual blood clot 204 is captured into the inside of the blood clot removal device 1000 through the open invitation, and the blood clot removal device 1000 is then used. The blood clot 204 can be removed by collecting it outside the blood vessel 201. In the case of a thrombus removal device having a closed arrangement, it is disadvantageous to remove the acupoints 204 compared to the thrombus removal device 1000 having an open arrangement because the open invitation is not formed and thus the acupuncture points 204 cannot be captured therein. It may be possible, and in some cases, it may not be possible to remove the acupuncture points 204.

The blood clot removal device according to an embodiment of the present specification may include one or more bodies. The body may be implemented using nitinol, but is not limited thereto. For example, the body may be implemented with a material other than nitinol, or may be implemented using a material other than nitinol. Alternatively, the body may include a radiopaque material. Examples of the radiopaque material include, but are not limited to, gold, platinum, palladium, tantalum, and tungsten alloy. When the body includes a radiopaque material, visibility of the body may be improved. For example, if the body contains a radiopaque material, the position or shape of the body may be determined even when the body is disposed in a blood vessel.

The distal end of the body may be tapered. For example, at least one of the proximal and distal end portions of the body may be tapered. 3 and 4, the first body 11000 and the second body 12000 may each include a first proximal end portion 11300 and a second proximal end portion 12300 that are tapered.

The distal ends of the body are tapered so that they can be gathered at one point. For example, the proximal end portion of the body may be tapered to gather at a proximal end point. In another example, the distal end portion of the body may be tapered and gather at a distal end point.

The blood clot removal device according to the exemplary embodiment of the present specification may include a first body and a second body. 3 and 4, the blood clot removal device 1000 may include a first body 11000 and a second body 12000. The first body 11000 and the second body 12000 may have a tube shape that is elongated in one direction and has an empty inside. The first body 11000 and the second body 12000 may be disposed in the blood vessel so that the length direction thereof follows the extension direction of the blood vessel.

One of the first body and the second body may be disposed inside the other body. For example, referring to FIGS. 3 and 4, the second body 12000 may be disposed inside the first body 11000. Alternatively, one of the first body and the second body may be positioned proximal or distal to the other body.

The first body and the second body may be disposed to overlap each other. For example, the first body and the second body may at least partially overlap along the length direction of the blood clot removal device. Here, as shown in FIGS. 3 and 4, the first body and the second body may at least partially overlap along the length direction in both a closed arrangement and an open arrangement.

The first body and the second body can move relative to each other. For example, referring to FIGS. 3 and 4, the first body 11000 and the second body 12000 may move relatively along the length direction of the blood clot removal device 1000. As another example, the first body and the second body may be relatively rotated along the circumferential direction of the blood clot removal device. Of course, the first body and the second body may rotate in the circumferential direction and may move along the length direction.

The positional relationship between the first body and the second body may be changed by the relative movement between the first body and the second body. For example, the first body and the second body may have a first positional relationship and a second positional relationship different from the first positional relationship. In addition, the first body and the second body may have a third positional relationship different from the first positional relationship and the second positional relationship.

The second positional relationship may be a positional relationship in which one of the first body and the second body has moved proximal or distal to the first positional relationship. 3 and 4, the positional relationship between the first body 11000 and the second body 12000 is that the first body 11000 moves distal to the second body 12000 or the second body ( 12000 may be moved proximally compared to the first body 11000 and may be changed from the first positional relationship of FIG. 3 to the second positional relationship of FIG. 4. Here, the second positional relationship is a positional relationship in which one of the first body 11000 and the second body 12000 moves along the length direction of the blood clot removal device 1000 compared to the first positional relationship. Can be The third positional relationship may be an intermediate positional relationship between the first positional relationship and the second positional relationship. For example, one of the first and second bodies is relatively moved in one of the proximal and distal directions to change from the first position to the third position, and the one body is moved back to the one direction. It can be moved to change from the third positional relationship to the second positional relationship.

Alternatively, the second positional relationship may be a positional relationship in which one of the first body and the second body rotates along the circumferential direction of the blood clot removal device compared to the first positional relationship.

The arrangement of the blood clot removal device may be determined according to a positional relationship between the first body and the second body. For example, when the positional relationship between the first body and the second body is a first positional relationship, the blood clot removal device has a first arrangement, and when the positional relationship between the first body and the second body is a second positional relationship, the blood clot is removed. The device may have a second arrangement. In addition, when the positional relationship between the first body and the second body is the third positional relationship, the blood clot removal device may have a third arrangement.

As the positional relationship between the first body and the second body is changed, the arrangement of the blood clot removal device may be changed. For example, as the positional relationship between the first body and the second body is changed from the first positional relationship to the second positional relationship, the arrangement of the blood clot removal device may be changed from the first arrangement to the second arrangement.

At least one of the first body and the second body may be moved to change the arrangement of the blood clot removal device. For example, one of the first body and the second body may be fixed and the other body may be moved to change the arrangement of the blood clot removal device. As another example, the arrangement of the blood clot removal device may be changed by moving both the first body and the second body. Among the plurality of bodies, a body that actually moves may be referred to as a moving body, and a body that does not move may be referred to as a base body.

According to an embodiment, the body may include at least one of a segment and a mouth structure. Here, the segment may be a part that binds to the blood clot. For example, a thrombus can be associated with a body or a blood clot removal device by engaging the segment. As a non-limiting example, the segment may be provided in the shape of a tube. In addition, the mouse structure may be a part configured to allow the blood clot to enter the body or the inside of the blood clot removal device. For example, the blood clot may be introduced or trapped into the body or the inside of the blood clot removal device through the structure of the mouse. 3 and 4, the first body 11000 may include segments 11100a, 11100b, and 11100c and mouse structures 11200a and 11200b. In addition, the second body 12000 may include segments 12100a and 12100b and a mouse structure 12200a.

The mouse structure can be located between the segments. For example, the mouse structure may be positioned between a first segment and a second segment located distal to the first segment. 3 and 4, the first mouse structure 11200a of the first body 11000 is located between the first segment 11100a and the second segment 11100b, and the second mouse structure 11200b is It may be positioned between the two segments 11100b and the third segment 11100c. In addition, the mouse structure 12200a of the second body 12000 may be positioned between the first segment 12100a and the second segment 12100b.

The number of mouse structures included in one body may correspond to the number of segments included in another body. For example, the number of mouse structures included in one body may be the same as the number of segments included in another body. 3 and 4, a first body 11000 may include two mouse structures 11200a and 11200b, and a second body 12000 may include two segments 12100a and 12100b.

The number of mouse structures included in one body may correspond to the number of segments included in the one body. For example, the number of mouse structures included in one body may be smaller than the number of segments included in the one body. 3 and 4, the first body 11000 includes two mouse structures 11200a, 11200b and three segments 11100a, 11100b, 11100c, and the second body 12000 includes one mouse. It may include structure 12200a and two segments 12100a and 12100b.

The size of the radially open area in the segment may be different from the size of the radially open area in the mouse structure. For example, in the mouse structure, the size of the area open in the radial direction may be larger than the size of the area opened in the radial direction in the segment. 7 is a diagram of a segment and a structure of a mouse of a blood clot removal device according to an embodiment of the present specification. Referring to FIG. 7, the size of the area 11101 that is opened in the radial direction of the first mouse structure 11200a of the first body 11000 is the areas 11101a and 11101b that are opened in the radial direction of the first segment 11100a. Can be larger than the size of ).

The size of the cell included in the segment may be different from the size of the cell included in the mouse structure. For example, the size of the cell included in the mouse structure may be larger than the size of the cell included in the segment. Referring to FIG. 7 from a cell perspective, the mouse structure 11200a may include a cell 11201 having a size larger than the cells 11101a and 11101b included in the segment 11100a. Here, the size of the cell included in the mouse structure may be a size at which a blood clot can be captured inside the first body. For example, referring to FIG. 7, the size of the cell 11201 included in the mouse structure 11200a may be larger than that of a blood clot. Of course, since the size of the blood clot may be different depending on the case, a general case is described here. In some cases, the size of the blood clot may be larger than the size of a cell included in the mouse structure.

In FIG. 7, the structure of the first segment and the first mouse of the first body has been described, but the same may be applied to other segments and structures of the mouse. In addition, although the segment of the first body and the structure of the mouse have been described in FIG. 7, the same may be applied to the second body.

The correspondence relationship between the segment and the mouse structure may vary according to the positional relationship between the first body and the second body. For example, when the first body and the second body have a first positional relationship, one of the first body and the second body corresponds to the other segment of the first body and the second body, and the second In the case of a positional relationship, one of the first body and the second body may correspond to the other one of the first body and the second body.

Correspondence relationships between different body segments and mouse structures may vary according to the arrangement of the blood clot removal device. For example, when the blood clot removal device has a first arrangement, a mouse structure of one of the first body and the second body corresponds to the other segment of the first body and the second body, and has a second arrangement. In this case, one of the first body and the second body may correspond to the other one of the first body and the second body.

Referring to FIGS. 3 and 4, in the blood clot removal device 1000 having the arrangement or positional relationship as shown in FIG. 3, the mouse structures 11200a and 11200b of the first body 11000 are segments of the second body 12000 ( In the blood clot removal device 1000 corresponding to each other and having an arrangement or positional relationship as shown in FIG. 4, the mouse structure 11200a of the first body 11000 is the mouse structure 12200a of the second body 12000. ) And can correspond to each other.

Whether or not an open invitation is formed in a blood clot removal device may vary according to a correspondence relationship between segments of different bodies and a mouse structure.

For example, when a mouse structure of one body and a mouse structure of another body correspond to each other, an open invitation may be formed in the blood clot removal device. Referring to FIG. 4, the first mouse structure 11200a of the first body 11000 and the mouse structure 12200a of the second body 12000 correspond to each other, so that a first open invitation ( 1100a) may be formed.

As another example, when a mouse structure of one body and a segment of another body correspond to each other, an open invitation may not be formed in the blood clot removal device. Referring to FIG. 3, the first mouse structure 11200a and the second mouse structure 11200b of the first body 11000 are respectively a first segment 12100a and a second segment 12100b of the second body 12000. Corresponding to that, the open invitation may not be formed in the blood clot removal device 1000.

The open invitation may correspond to one or more mouse structures. One open invitation may correspond to one mouse structure, and the other open invitation may correspond to a plurality of mouse structures. For example, referring to FIG. 4, the first open invitation 1100a corresponds to the first mouse structure 11200a of the first body 11000 and the mouse structure 12200a of the second body 12000, The second open invitation 1100b may correspond to the second mouse structure 11200b of the first body 11000.

At least some mouse structures of one body may not have a segment of another body or a mouse structure corresponding thereto according to the arrangement of the blood clot removal device. In this case, the structure of the at least some mice may correspond to the open invitation of the blood clot removal device. For example, referring to FIG. 4, the second mouse structure 11200b of the first body 11000 does not have a segment or mouse structure of the second body 12000 corresponding thereto, and the second mouse structure ( 11200b) corresponds to the open invitation 1100b of the blood clot removal device 1000 so that the blood clot may flow into the blood clot removing device 1000 or the first body 11000 through the second mouse structure 11200b. have.

The mouse structure may include one or more bridges. Here, the bridge may connect adjacent segments. 8 is a diagram of a bridge of a blood clot removal device according to an embodiment of the present specification. Referring to FIG. 8, the first mouse structure 11200a may include first bridges 11202a and 11202b connecting the first segment 11100a and the second segment 11100b. In addition, the second mouse structure 11200b may include second bridges 11202c and 11202d connecting the second segment 11100b and the third segment 11100c.

According to an embodiment, the bridge may connect a distal end portion of one segment located proximal to the bridge and a proximal end portion of another segment located distal to the bridge. Referring to FIG. 8, a first body 11000 includes a first bridge 11202a, 11202b and a second segment 11100b connecting the distal end portion of the first segment 11100a and the proximal end portion of the second segment 11100b. And second bridges 11202c and 11202d connecting the distal end of the and the proximal end of the third segment 11100c.

According to an embodiment, the bridge may be located on a circumferential surface of a blood clot removal device or body. Referring to FIG. 8, the bridges 11202a, 11202b, 11202c, and 11202d may be located on the circumferential surface of the first body 1000. When the bridge is located on the circumferential surface, it may be more advantageous to capture the blood clot into the blood clot removal device or the body, compared to the case where the bridge is located on or near the longitudinal axis of the blood clot removal device or body. It is not limited to.

According to an embodiment, the mouse structure may include two bridges facing each other. Referring to FIG. 8, the first mouse structure 11200a includes a 1-1 bridge 11202a and a 1-2 bridge 11202b facing each other, and the second mouse structure 11200b is a first mouse structure 11200b facing each other. It may include a 2-1 bridge 11202c and a 2-2 bridge 11202d.

According to an embodiment, bridges included in different mouth structures of one body may be located at different positions on a circumferential cross section. Alternatively, bridges included in different mouth structures of one body may be disposed at positions on different circumferential directions. For example, the first bridge included in the first mouth structure and the second bridge included in the second mouth structure may be positioned at different positions on the circumferential cross section. Referring to FIG. 8, the first bridges 11202a and 11202b may be positioned vertically on the circumferential cross-section, and the second bridges 11202c and 11202d may be positioned horizontally on the circumferential cross-section. That is, the first bridges 11202a and 11202b and the second bridges 11202c and 11202d may be disposed to be spaced apart at 90° intervals along the circumferential direction. However, the position on the circumferential cross-section of the bridge is not limited thereto, and may be variously implemented as described later.

As the bridges are located at different positions on the circumferential cross section, it may be advantageous to capture the blood clots into the inside of the clot removal device or body. For example, unlike FIG. 8, when the first bridge and the second bridge are positioned in the same vertical direction, a blood clot positioned in the horizontal direction is advantageous to be captured inside the blood clot removal device or body, but a blood clot positioned in the vertical direction This clot removal device or trapped inside the body can be prevented by the bridge. On the other hand, when the bridge is located as shown in FIG. 8, the thrombus located in the horizontal direction is captured in the first mouse structure 11200a, and the thrombus located in the vertical direction can be captured in the second mouse structure 11200b. Regardless, the clot can be trapped inside the clot removal device or the body.

The bridge of one body and the bridge of the other body corresponding thereto may be provided to overlap each other when the blood clot removal device is an open arrangement. Here, the overlapping of the bridges may mean that the bridges are disposed at the same position in the circumferential direction of the blood clot removal device. For example, in an open arrangement, the bridge of the first body and the bridge of the second body corresponding thereto may overlap each other. Referring to FIG. 4, the bridge of the first mouse structure 11200a of the first body 11000 and the bridge of the mouse structure 12200a of the second body 12000 corresponding thereto may overlap each other. Accordingly, it may be reduced or minimized that the bridge interferes with the influx of blood clots through the open invitation.

The blood clot removal device according to an embodiment of the present specification may further include one or more pull wires. The full wire may be made of nitinol, stainless steel, or the like, but is not limited thereto.

At least one of the first body and the second body may be directly or indirectly connected to the full wire. For example, the first body and the second body may be directly or indirectly connected to the first full wire and the second full wire, respectively. 9 is a view of a pull wire of the blood clot removal device according to an embodiment of the present specification. Referring to FIG. 9, a first body 21000 may be connected to a first full wire 23000, and a second body 22000 may be connected to a second full wire 24000. In FIG. 9, it is illustrated that the pull wires 23000 and 24000 are directly connected to the proximal end portions of the first body 21000 and the second body 22000, but are not limited thereto.

At least one of the first body and the second body may be manipulated by a full wire connected thereto. For example, referring to FIG. 9, the second body 22000 may be moved by a second full wire 24000 connected thereto. As at least one of the first body and the second body is manipulated by a full wire connected thereto, the positional relationship between the first body and the second body may be changed. Alternatively, as at least one of the first body and the second body is manipulated by a pull wire connected thereto, the arrangement of the blood clot removal device may be changed.

A hollow may be formed inside the pull wire. In this case, the pull wire may also be referred to as a pull tube.

At least some areas of the pull wire may be disposed or inserted into the inside of the pull tube. 10 is a view of a pull wire disposed inside the pull tube according to an embodiment of the present specification. 10 shows cross-sections of pull tubes 23000a, 23000b, 23000c, and 23000d and pull wires 24000a, 24000b, 24000c, and 24000d disposed in the inner hollow thereof. At least some regions of the pull wire disposed or inserted inside the pull tube may include a region adjacent to the body. Alternatively, the at least some regions may include a distal region of a full tube or a full wire.

The relative rotational motion between the plurality of pull wires may be limited. Accordingly, a relative rotational motion between a plurality of bodies connected to the pull wire may be limited.

In order to limit the relative rotational motion between the plurality of pull wires, at least one of the plurality of pull wires may include a rotation preventing structure. Alternatively, a rotation preventing structure may be formed on at least one of the plurality of pull wires. Referring to FIG. 10, the relative rotation between the pull tube 23000b and the pull wire 24000b is limited by the groove formed in the pull tube 23000b and the protrusion formed in the pull wire 24000b and disposed to correspond to the groove. Can be. Here, the rotation preventing structure 26000 may include the groove and the protrusion.

The relative rotational motion between the plurality of pull wires may be limited by the shape of the pull wire. For example, referring to FIG. 10, a pull wire 24000c having a rectangular cross-section and a full tube 23000c having a rectangular hollow cross-section may be provided. Accordingly, a relative rotational motion between the pull wire 24000c and the pull tube 23000c may be limited. In FIG. 10, a case in which the cross section is a square is illustrated, but in addition to this, the cross section such as a triangle and a pentagon may be a polygon of various shapes. As another example, a plurality of pull wires may be provided in a cross-sectional shape including a major axis and a minor axis having different lengths. Accordingly, a relative rotational motion between the plurality of pull wires may be limited. As a non-limiting example, referring to FIG. 10, a pull wire 24000d having an elliptical cross section and a full tube 23000d having a hollow elliptical cross section may be provided.

In FIG. 10, it has been described that the blood clot removal device includes one full tube, but the blood clot removal device may include two full tubes. As a non-limiting example, when the pull wires 24000a, 24000b, 24000c, and 24000d of FIG. 10 are provided to have an empty shape, this may also be referred to as a full tube. In this case, the blood clot removal device includes a first full tube and It may include a second full tube.

The apparatus for removing blood clots according to the exemplary embodiment of the present specification may further include a stopper.

The stopper may determine a boundary of a relative motion between the first body and the second body. For example, the stopper may cause the first body and the second body to move between the first positional relationship and the second positional relationship. Alternatively, the stopper may limit a maximum positional relationship between the first body and the second body. For example, movement of the blood clot removing device of the first body and the second body in the longitudinal direction may be limited by the stopper. Accordingly, the stopper may prevent one of the first body and the second body from moving excessively with respect to the other.

The position where the stopper is provided may correspond to the size of the open invitation. Alternatively, the position where the stopper is provided may be determined based on the size of the open invitation. For example, the distance between the stopper disposed on the first pull wire and the end of the second pull wire may correspond to a length in the length direction of the blood clot removing device of the open invitation. Here, the distance between the stopper and the end of the second pull wire is a distance when the blood clot removing device is in the first arrangement, and the open invitation may be formed when the blood clot removing device is in the second arrangement. 11 is a diagram illustrating a stopper of a blood clot removing device according to an exemplary embodiment of the present specification. Referring to FIG. 11, a distance d1 between a stopper 25000 disposed on a pull wire 24000 and a distal end of the pull tube 23000 in a case where the blood clot removal device 2000 is in a closed arrangement is the blood clot removal device 2000 May correspond to the length d2 of the open invitation 2100a formed in the case of an open arrangement. Here, d1 may be substantially the same as d2.

The position where the stopper is provided may correspond to the size of the mouse structure. Alternatively, the position where the stopper is provided may be determined based on the size of the mouse structure. For example, a distance between a stopper disposed on the first pull wire and the end of the second pull wire may be substantially equal to the length of the mouth structure.

The stopper may be attached or formed on one area of the pull wire. Referring to FIG. 11, the stopper 25000 may be provided in a form protruding from the pull wire 24000 in one area of the pull wire 24000. Here, the stopper 25000 may be located distal to the distal end of the full tube 23000.

The stopper may limit the insertion of one area of the pull wire into the inside of the pull tube. For example, as a stopper is formed on the pull wire, one area of the pull wire may not be inserted into the pull tube. Here, the one region may be a region located on the opposite side of the full tube with respect to the stopper. Referring to FIG. 11, a region of the pull wire 24000 located distal to the stopper 25000 may be restricted from being inserted into the pull tube 23000 by the stopper 25000.

The apparatus for removing blood clots according to the exemplary embodiment of the present specification may further include a locking mechanism. 12 is a diagram illustrating a locking structure of a blood clot removing device according to an exemplary embodiment of the present specification. Referring to FIG. 12, the locking structure 27000 may be located in a proximal region of the blood clot removal device. The proximal region may be located outside the body. Alternatively, the locking structure 27000 may be located at the proximal end of the pull tube 23000.

According to an embodiment, the locking structure may enable or disable the first body and the second body to move relatively. For example, when the locking structure is in the first state, the first body and the second body can be moved relatively, and when the locking structure is in the second state, the first body and the second body cannot be moved relatively. Alternatively, the locking structure may enable or disable the first pull wire and the second pull wire to move relatively. For example, when the locking structure is in the first state, the first pull wire and the second pull wire can be moved relatively, and when the locking structure is in the second state, the first pull wire and the second pull wire are relatively movable. none.

Referring to FIG. 12, when the locking structure 27000 is in the first state, the first body 21000 and the second body 22000 cannot be moved relatively. Accordingly, the blood clot removal device 2000 may maintain a current arrangement, such as maintaining a closed arrangement or an open arrangement. On the other hand, when the locking structure 27000 is in the second state, the first body 21000 and the second body 22000 may move relatively. Accordingly, the blood clot removal device 2000 may change its arrangement, such as changing from a closed arrangement to an open arrangement or changing from an open arrangement to a closed arrangement.

The apparatus for removing blood clots according to the exemplary embodiment of the present specification may further include a locking stopper. Referring to FIG. 12, the locking stopper 27500 may be provided adjacent to the locking structure 27000. In addition, the locking stopper 27500 may be located outside the body.

The locking stopper may determine a boundary of relative motion between the first body and the second body. For example, the locking stopper may cause the first body and the second body to move between the first positional relationship and the second positional relationship. Alternatively, the lock stopper may limit a maximum positional relationship between the first body and the second body. For example, movement of the blood clot removing device of the first body and the second body in the longitudinal direction may be limited by the locking stopper. Accordingly, the locking stopper may prevent excessive movement of one of the first body and the second body. Referring to FIG. 12, it is possible to prevent the second body 22000 from being positioned distal to the first body 21000 beyond a predetermined range by the locking stopper 27500.

The position where the lock stopper is disposed may correspond to the size of the open invitation. Alternatively, the position where the lock stopper is disposed may be determined based on the size of the open invitation. For example, the distance between the locking stopper and the distal end of the locking structure may correspond to the length in the longitudinal direction of the blood clot removing device of the open invitation. Here, the distance between the locking stopper and the end of the locking structure is a distance when the blood clot removing device is in the first arrangement, and the open invitation may be formed when the blood clot removing device is in the first arrangement. For example, referring to FIG. 12, when the blood clot removal device 2000 is in an open arrangement, the distance d5 between the locking stopper 27500 disposed on the pull wire 24000 and the proximal end of the locking structure 27000 is a blood clot It may correspond to the length d4 of the open invitation formed when the removal device 2000 is an open arrangement. Here, d4 may be substantially the same as d5.

The position where the locking stopper is disposed may correspond to the size of the mouse structure. Alternatively, the position at which the locking stopper is disposed may be determined based on the size of the mouse structure. For example, the distance between the locking stopper and the distal end of the locking structure can be substantially equal to the length of the mouth structure.

The position where the lock stopper is disposed may correspond to the position where the stopper is disposed. For example, the distance between the locking stopper and the end of the locking structure may correspond to the distance between the stopper disposed on the first pull wire and the end of the second pull wire. Here, the distance between the locking stopper and the end of the locking structure is a distance when the blood clot removing device is in the first arrangement, and the distance between the stopper and the end of the second pull wire is when the blood clot removing device is in the second arrangement It can be the distance of. Referring to FIG. 12, the distance d5 between the locking stopper 27500 and the proximal end of the locking structure 27000 in the case where the blood clot removal device 2000 is in an open arrangement is when the blood clot removal device 2000 is in a closed configuration. May correspond to the distance d3 between the distal end of the pull tube and the stopper of. Here, d3 may be substantially the same as d5.

The locking stopper may be attached or formed on one area of the pull wire. For example, referring to FIG. 12, the locking stopper 27500 may be provided in a form protruding from the pull wire 24000 in one area of the pull wire 24000. Here, the locking stopper 27500 may be located proximal to the proximal end of the locking structure 27000. Alternatively, the locking stopper 27500 may be positioned proximal to the proximal end of the pull tube 23000.

The locking stopper may limit the insertion of one area of the pull wire into the lock structure or the inside of the pull tube. For example, as the lock stopper is formed on the pull wire, one area of the pull wire may not be able to be inserted into the lock structure or the pull tube. Here, the one region may be a region located on the opposite side of the locking structure or the full tube based on the locking stopper. Referring to FIG. 12, a region of the pull wire 24000 positioned proximal to the lock stopper 27500 may be restricted from being inserted into the lock structure 27000 by the lock stopper 27500. Alternatively, a region of the pull wire 24000 positioned proximal to the lock stopper 27500 may be restricted from being inserted into the pull tube 23000 by the lock stopper 27500.

The apparatus for removing blood clots according to an embodiment of the present specification may further include a basket. 13 is a diagram illustrating a basket of a blood clot removing device according to an exemplary embodiment of the present specification. 13, a mesh 38000a, which is an example of a basket, is connected to the distal end of the first body 31000, and a cage 38000b, which is another example of the basket, is connected to the distal end of the second body 32000. Can be connected. Here, the mesh means a basket formed through braiding of a wire. In addition, the cage means a basket including one or more wires but not formed by braiding. In addition to this, the basket may be implemented using a porous polymer, but is not limited to the above-described example.

The cell size of the basket may be smaller than the cell size of the body. Referring to FIG. 13, the cell sizes of the mesh 38000a and the cage 38000b may be smaller than the cell sizes of the first body 31000 and the second body 32000. As a non-limiting example, the cell size of the basket may be several tens of μm to several hundreds of μm.

The wire thickness of the basket may be less than the wire thickness of the body. As a non-limiting example, the wire thickness of the basket may be about 0.5 times the wire thickness of the body. Accordingly, the basket can be more flexible than the body. Alternatively, the radial force provided by the basket to the vessel wall may be smaller than that of the body.

The basket may be implemented using nitinol, but is not limited thereto. For example, the basket may be implemented with a material other than nitinol, or may be implemented using a material other than nitinol. Alternatively, the basket may contain a radiopaque material. When the basket contains a radiopaque material, visibility of the basket may be improved. For example, if the basket contains a radiopaque material, even when the basket is disposed in a blood vessel, the position or shape of the basket can be determined.

Baskets may be provided to be positioned between adjacent open invitations. For example, the basket may be provided to be positioned between two adjacent open invitations in the longitudinal direction when the blood clot removal device is an open arrangement. Referring to FIG. 13, the cage 38000b may be positioned between the first open invitation 3100a and the second open invitation 3100b.

The basket may be connected to the distal end of the segment. Referring to FIG. 13, the mesh 38000a may be connected to a distal end portion of a distal-most segment of the first body 31000. Further, the cage 38000b may be connected with a distal end portion of the distalmost segment of the second body 32000. In FIG. 13, only the case where the basket is connected to the distal-most segment is illustrated, but the basket may be connected to other segments other than the distal-most segment.

The basket may be provided to be positioned on top of the mouse structure. Referring to FIG. 13, the mesh 38000a may be positioned at a distal position of the most distal mouse structure of the first body 31000. Further, the cage 38000b may be located distal to the mouth structure of the second body 32000.

The basket may prevent the blood clots from entering the blood clot removal device or from leaving the trapped blood clots to the outside.

As an example, the basket may prevent a blood clot from flowing into the inside of the blood clot removal device or from being trapped to the outside through a distal end of the blood clot removal device. Referring to FIG. 13, the mesh 38000a connected to the first body 31000 prevents the thrombus 205 trapped inside the thrombus removal device 3000 from escaping to the outside through the distal end of the thrombus removal device 3000. Can be prevented.

As another example, the basket may prevent a blood clot from entering or leaving the blood clot removal device to the outside through an open invitation of the blood clot removal device. Referring to FIG. 13, the cage 38000b connected to the second body 32000 includes a blood clot 205 captured inside the blood clot removal device 3000 through the first open invitation 3100a. 3100b) can be prevented from deviating to the outside.

Baskets can remove small-sized clots, such as fragments that have fallen off the clots. For example, a blood clot or clot fragment smaller than the size of the cell may not be able to bind to or be captured by the body. On the other hand, when the blood clot removal device includes a basket having a cell size smaller than the cell size of the body, small blood clots or blood clot fragments may be captured by the basket. Referring to FIG. 13, as the blood clot removal device 3000 is disposed in a blood vessel and then collected outside the body, small blood clots or clot fragments that are about to escape to the distal end of the blood clot removal device 3000 are mesh 38000a or cage 38000b. It is captured by the blood clot removal device 3000 and cannot be removed from the body and can be removed.

13 illustrates that the mesh is connected to the first body and the cage is connected to the second body, but is not limited thereto. In addition to the mesh and the cage, the basket may be variously implemented to prevent the blood clots captured inside the blood clot removal device from escaping to the outside. In addition, the basket may be connected to only one of the first body and the second body, and at least one of the first body and the second body may be connected to a plurality of baskets.

On the other hand, in order to effectively remove a small thrombus or thrombus fragments in the basket, adhesion between the basket and blood vessels may be important. For example, if the basket is not in close contact with the blood vessel due to the blood clot removal device passing through a serpentine blood vessel or excessively extending in the longitudinal direction, small blood clots or blood clot fragments may escape into the space between the basket and the blood vessel. .

14 is a diagram illustrating a connection between a body and a basket of a blood clot removal device according to an exemplary embodiment of the present specification. Referring to FIG. 14, as shown in the first type, substantially the entire area of the proximal end of the mesh 38000a may be connected to the body. In this case, as the body expands or compresses in the radial direction, the mesh 38000a may also expand or compress together with the body. Accordingly, the radial width w1 of the mesh 38000a when the body is expanded may be larger than the radial width w2 of the mesh 38000a when the body is compressed.

On the other hand, as shown in the second type of FIG. 14, the proximal end and the body of the mesh 38000a may be connected by one or more connection lines 38001. In this case, as the body is compressed, even if the proximal ends of the mesh 38000a are compressed together, the central portion may not be compressed or may be compressed less. Accordingly, the radial width w3 of the mesh 38000a when the body is expanded may be substantially the same as the maximum radial width w4 of the mesh 38000a when the body is compressed. Alternatively, w4 may be greater than w2.

Alternatively, as shown in the third type of FIG. 14, the mesh 38000a and the body may be connected at a connection portion separated by a predetermined distance in the distal direction from the proximal end of the mesh 38000a. In this case, as the body is compressed, even if the connection portions are compressed together, the proximal end of the mesh 38000a may not be compressed or may be compressed less. Accordingly, the radial width w5 of the mesh 38000a when the body is expanded may be substantially the same as the radial width w6 at the proximal end of the mesh 38000a when the body is compressed. Alternatively, w6 may be greater than w2.

Referring to FIG. 14, when a mesh and a body are connected like the second type or the third type, the adhesion between the mesh and the blood vessel may increase compared to the first type. Accordingly, the space between the mesh and the body is reduced, so that it is possible to reduce the escape of small blood clots or blood clot fragments into the space.

In FIG. 14, the mesh has been described, but this may be applied to a basket of other shapes other than the mesh.

As the blood clot removal device includes a basket, the size of the open invitation may decrease. 15 is a diagram illustrating a size of an open invitation according to a basket of a blood clot removal device according to an exemplary embodiment of the present specification. Referring to FIG. 15, as the cage 38000b is provided, the length of the open invitation may decrease from d8 to d7.

If the size of the open invitation is reduced, it may be difficult for the blood clot to flow into the blood clot removal device through the open invitation. That is, a basket disposed near the open invitation, particularly in the proximal portion of the open invitation, may prevent the blood clot removal device from capturing the blood clot.

Thus, the length of the basket can be minimized. Referring to FIG. 15, the length d6 of the cage 38000b may be smaller than the length d7 of the open invitation. For example, d7 may be 10 times or more, 5 times or more, or 2 times or more than d6.

As the blood clot removal device includes a basket, the distal end of the blood clot removal device may have a closed shape. Alternatively, as the basket is connected to the distal end of the body, the distal end of the body may have a closed shape.

The blood clot removal device or body may include a closed end portion even when the basket is not included. For example, when a wire or strut of a body is made to be gathered at or near a central axis in the longitudinal direction at the end, the distal end of the body may have a closed shape.

According to an embodiment, the basket may include a marker. Here, the marker means a member having visibility by being made to include a radiopaque material. As the basket includes the marker, it is possible to check whether or not the blood clot has been captured into the inside of the blood clot removal device.

16 is a diagram illustrating a basket including a marker of a blood clot removal device according to an exemplary embodiment of the present specification. Referring to FIG. 16, the basket 38000 may include one or more markers 3802. The location or arrangement of the markers may be different depending on whether a thrombus has been introduced into the basket. Therefore, it is possible to confirm whether the blood clot removal device has captured the blood clot by checking the position or arrangement of the markers. Referring to FIG. 16, before the thrombus 206 is introduced into the basket 38000, the markers 3802, which were gathered together, increase as the thrombus 206 is introduced, and the position or arrangement of the markers is checked from the outside. The influx of thrombus 206 may be confirmed.

The blood clot removal device according to an embodiment of the present specification may further include an anti-stretch wire. Here, the anti-stretch wire may prevent the blood clot removing device or body from being excessively stretched.

The anti-stretch wire may be made of a polymer material or a metal material such as nitinol or stainless steel, but is not limited thereto.

The blood clot removal device according to an embodiment of the present specification may include one or more anti-stretch wires. For example, some bodies of the blood clot removal device may be connected to the anti-stretch wire and the other body may not be connected to the anti-stretch wire. Alternatively, all the bodies of the blood clot removal device may be connected to the anti-stretch wire. Hereinafter, for convenience of description, the body connected to the anti-stretch wire is referred to as an anti-stretch body.

When all the bodies of the blood clot removal device are anti-stretch bodies, the anti-stretch effect can be maximized. For example, if the blood clot removal device includes an anti-stretch body and a body that is not connected with the anti-stretch wire, the body that is not connected with the anti-stretch wire is excessively stretched even if the anti-stretch body is not overstretched. As a result, the blood clot that is trapped or bound to the blood clot removal device may be released. On the other hand, when the blood clot removal device includes only an anti-stretch body, it is possible to prevent the blood clot from being separated by not overstretching all the bodies.

The number of anti-stretch wires connected to one body of the blood clot removal device according to the exemplary embodiment of the present specification may be determined based on the number of mouse structures of the one body. As a non-limiting example, the number of anti-stretch wires connected to one body may be greater than or equal to the number of mouse structures of one body.

The number of anti-stretch wires connected to one body of the blood clot removal device according to the exemplary embodiment of the present specification may be determined based on the number of segments of the one body. As a non-limiting example, the number of anti-stretch wires connected to one body may be less than or equal to the number of segments of the one body.

17 and 18 are diagrams of an anti-stretch wire of an apparatus for removing blood clots according to an exemplary embodiment of the present specification. Referring to FIG. 17, the first body 41000 may be connected to the anti-stretch wires 49100a and 49100b. Referring to FIG. 18, the first body 151000 may be connected to the anti-stretch wires 159100a, 159100b, and 159100c.

Both ends of the anti-stretch wire can be connected to the body at two different points. In this specification, the point at which the anti-stretch wire and the body are connected is referred to as a coupling point.

The front and rear ends of the anti-stretch wire can be connected with the body at the front coupling point and the rear coupling point, respectively. Here, the front coupling point may be located proximal to the rear coupling point. Referring to FIG. 17, the first anti-stretch wire 49100a and the first body 41000 may be connected at a first potential coupling point 49101a and a first rear coupling point 49102a. In addition, the second anti-stretch wire 49100b and the first body 41000 may be connected at the second potential coupling point 49101b and the second rear coupling point 49102b. Referring to FIG. 18, the first anti-stretch wire 159100a and the first body 151000 may be connected at a first potential coupling point 159101a and a first rear coupling point 159102a. In addition, the second anti-stretch wire 159100b and the first body 151000 may be connected at the second potential coupling point 159101b and the second rear coupling point 159102b. In addition, the third anti-stretch wire 159100c and the first body 151000 may be connected at the third potential coupling point 159101c and the third rear coupling point 159102c. The coupling point may be located on the circumferential surface of the body, but is not limited thereto.

The length of the anti-stretch wire may be greater than the distance between the front coupling point and the rear coupling point (hereinafter referred to as "coupling distance"). For example, the length of the anti-stretch wire can be at least 1.1 times, at least 1.2 times, or at least 1.5 times the coupling distance.

The anti-stretch wire can be arranged to extend along the bridge. In this case, even if the anti-stretch wire crosses the mouse structure, the open area of the mouse structure does not cross, so that the thrombus may not interfere with the inflow of the blood clot into the body through the mouse structure. Referring to FIG. 17, the first anti-stretch wire 49100a may be disposed to extend along the bridge 41202a while crossing the first mouth structure 41200a.

The anti-stretch wire can connect the proximal end of the proximal segment and the distal end of the distal segment.

Anti-stretch wires can be placed so as not to cross the mouth structure. Referring to FIG. 17, a first anti-stretch wire 49100a is disposed proximal to the second mouse structure 41200b so as not to cross the second mouse structure 41200b, and a second anti-stretch wire 49100b is disposed distal to the second mouse structure 41200b. ) Can be placed. Alternatively, the rear coupling point 49102a of the first anti-stretch wire 49100a is located proximal to the second mouth structure 41200b, and the potential coupling point 49101b of the second anti-stretch wire 49100b is It may be located distal to the second mouse structure 41200b. Referring to FIG. 18, a first anti-stretch wire (159100a) is disposed proximal to the first mouse structure (151200a) so as not to cross the first mouse structure (151200a), and a second anti-stretch wire (159100b) is distal. ) Can be placed. In addition, a second anti-stretch wire (159100b) is disposed proximal to the second mouse structure (151200b) so as not to cross the second mouse structure (151200b), and a third anti-stretch wire (159100c) is disposed distal. I can.

Although not shown, the anti-stretch wires may be disposed to face each other with respect to the central axis in the longitudinal direction of the body. Alternatively, a plurality of anti-stretch wires may be provided so as to be spaced apart by the same distance in the circumferential direction of the body.

The anti-stretch wire may extend along the circumferential surface of the clot removal device. Alternatively, the anti-stretch wire may extend along the central axis of the blood clot removal device.

In the above, the anti-stretch wire has been described with reference to the first body, but the above description may be applied to the second body as well.

The apparatus for removing blood clots according to an embodiment of the present specification may further include an anti-stretch strut. Anti-stretch struts can be placed inside the cell of the body to prevent the clot removal device or body from being excessively stretched. In this specification, a cell provided with an anti-stretch strut is referred to as an anti-stretch cell.

According to an embodiment, the blood clot removal device may include one or more anti-stretch cells. For example, the first body may include one or more anti-stretch cells. Further, the second body may include one or more anti-stretch cells.

19 is a diagram of an anti-stretch strut and an anti-stretch cell of a blood clot removal device according to an embodiment of the present specification. Referring to FIG. 19, the first body 51000 may include anti-stretch struts 59200a, 59200b, and 59200c. Alternatively, the first body 51000 may include anti-stretch cells 51101a, 51101b, and 51101c.

Both ends of the anti-stretch strut can be connected to the anti-stretch cell at two different points. Similar to the anti-stretch wire, in this specification, the point at which the anti-stretch strut and the anti-stretch cell are connected is referred to as a coupling point.

The front and rear ends of the anti-stretch strut can be connected with the anti-stretch cell at the front coupling point and the rear coupling point, respectively. Here, the front coupling point may be located proximal to the rear coupling point. Referring to FIG. 19, a first anti-stretch strut 59200a and a first anti-stretch cell 51101a may be connected at a first front coupling point and a first rear coupling point. Further, the second anti-stretch strut 59200b and the second anti-stretch cell 51101b may be connected at the second potential coupling point and the second rear coupling point. In addition, the third anti-stretch strut 59200c and the third anti-stretch cell 51101c may be connected at a third potential coupling point and a third rear coupling point. The coupling point may be located on the circumferential surface of the body, but is not limited thereto.

The length of the anti-stretch strut may be substantially equal to the coupling distance. Alternatively, the length of the anti-stretch strut may be greater than the coupling distance. For example, the length of the anti-stretch strut can be at least 1.1 times, at least 1.2 times, or at least 1.5 times the coupling distance.

In FIG. 19, the anti-stretch struts 59200a, 59200b, and 59200c are shown to be provided parallel to the longitudinal axis of the body, but are not limited thereto, and the anti-stretch strut is provided to have a predetermined angle with the longitudinal axis. Can be.

In addition, although one segment is shown to include one anti-stretch cell in FIG. 19, the segment may include a plurality of anti-stretch cells or may not include an anti-stretch cell.

The anti-stretch cells may be disposed to face each other with respect to a central axis in the longitudinal direction of the body. Alternatively, the plurality of anti-stretch cells may be disposed to be spaced apart by the same distance in the circumferential direction of the body.

The plurality of anti-stretch cells may be disposed to be spaced apart from each other along the length direction of the body. Referring to FIG. 19, a second anti-stretch cell 51101b is provided distal to the first anti-stretch cell 51101a, and a third anti-stretch cell distal of the second anti-stretch cell 51101b. (51101c) may be provided. Here, the spacing between adjacent anti-stretch cells in the longitudinal direction may be the same or different.

In the above, the anti-stretch strut and the anti-stretch cell have been described based on the first body, but the above-described information may be applied to the second body as well. In addition, similar to the anti-stretch wire described above, all bodies of the blood clot removal device may include an anti-stretch cell, but the present invention is not limited thereto.

The blood clot removal device according to an embodiment of the present specification may further include a catheter. The catheter may be provided in the form of a tube having a hollow inside. When the body is compressed and placed in the hollow and delivered to the target area and then only the catheter is moved in the proximal direction, the body can be expanded and disposed in the target area. As a non-limiting example, the catheter may have an inner diameter of about 0.5 mm.

The blood clot removal device according to the exemplary embodiment of the present specification may further include a guide wire. Here, the guide wire may be used to arrange the body in the target area. For example, the distal end of the guide wire is positioned distal to the blood clot by penetrating a blood clot located in the target area, and then the catheter in which the body is compressed is delivered as described above, and the body can be placed in the target area. have.

The blood clot removal device according to the embodiment of the present specification may be manufactured through various methods. Hereinafter, some examples of a method of manufacturing a blood clot removal device, particularly a body, according to an exemplary embodiment of the present specification will be described.

According to an example of a manufacturing method according to an embodiment of the present specification, the body may be manufactured in a bottom-up process. Here, the bottom-up process means manufacturing a body by deforming or shaping a wire. The body may be manufactured using only one type of wire, but may also be manufactured using a plurality of types of wire.

20 is a diagram illustrating an example of a wire structure of a blood clot removal device according to an embodiment of the present specification. Referring to FIG. 20, the wire 1 may have a core-shell structure made of different materials. Here, at least one of the core 1a and the shell 1b may be a shape memory alloy. For example, the shell 1b may be nitinol.

At least one of the core and the shell may be or include a radiopaque material. For example, referring to FIG. 20, the core 1a may be a radiopaque material. When the wire includes a radiopaque material, visibility of the blood clot removal device or body may be improved. For example, if the wire contains a radiopaque material, the location or shape of the blood clot removal device may be determined even when the blood clot removal device is disposed in a blood vessel.

21 is a diagram illustrating another example of a wire structure of a blood clot removing device according to an exemplary embodiment of the present specification. When comparing FIGS. 20 and 21, the wire 2 of FIG. 21 may be made of different materials, but may have a modified core-shell structure in which the core 2a is exposed to the outside. Similar to the wire 1 of FIG. 20, at least one of the core 2a and the shell 2b of FIG. 21 may be a shape memory alloy. In addition, at least one of the core 2a and the shell 2b may be a radiopaque material.

Of course, the wire may be provided in a single structure, unlike those shown in Figs. 20 and 21. For example, the wire may be provided in a simple cylindrical shape.

22 is a flowchart illustrating an example of a method of manufacturing a blood clot removing device according to an embodiment of the present specification. The bottom-up process, which is a manufacturing method according to an embodiment of the present specification, includes forming a one-dimensional pattern by forming a wire (S1100), forming a two-dimensional pattern by forming a wire (S1200), and forming a three-dimensional wire. It may include forming a pattern (S1300), bonding a junction of wires (S1400), and forming a coating layer (S1500).

The pattern of the wire may be formed through thermoforming. To this end, the wire may be made of a shape memory alloy or may be made of a shape memory alloy. An example of a shape memory alloy is nitinol, but is not limited thereto.

According to an embodiment, the step of forming a one-dimensional pattern by forming a wire (S1100) may be forming a wire using a fixture. 23 is a diagram illustrating formation of a one-dimensional pattern using a fixture according to an exemplary embodiment of the present specification. For example, the fixture 10a may include a post 11a. The wire 1 may be formed into a specific shape by the post 11a to form a one-dimensional pattern. As another example, the fixture 10b may include a groove 12b. The wire 3 may be formed into a specific shape by the groove 12b to form a one-dimensional pattern. 23 illustrates a wire formed in a sine wave pattern, but the present invention is not limited thereto, and the wire may be formed in various patterns.

According to an embodiment, the step of forming a two-dimensional pattern by forming a wire (S1200) may be forming a wire using a fixture. 24 is a diagram illustrating formation of a two-dimensional pattern using a fixture according to an exemplary embodiment of the present specification. For example, the fixture 10c may include a post 11c. The wire 4 may be formed into a specific shape by the post 11c to form a two-dimensional pattern. As another example, the fixture 10d may include a groove 12d. The wire 4 may be formed into a specific shape by the groove 12d to form a two-dimensional pattern.

The two-dimensional pattern may be classified according to the direction in which the wire extends. 25 is a diagram illustrating an extension direction of a wire of a two-dimensional pattern according to an exemplary embodiment of the present specification. Referring to FIG. 25, the wire 5 may extend in a vertical direction. Here, the vertical direction is a direction perpendicular to the longitudinal direction of the blood clot removing device or body, and may correspond to the circumferential direction of the blood clot removing device or the body. More specifically, the wire 5 may extend downward in the vertical direction and then upward in the vertical direction, which may be repeated to form a two-dimensional pattern. Alternatively, the wire 6 may extend in a horizontal direction. Here, the horizontal direction may correspond to a direction parallel to the longitudinal direction of the blood clot removing device or body. More specifically, the wire 6 may extend to the right in the horizontal direction and then to the left in the horizontal direction, and this may be repeated to form a two-dimensional pattern.

The two-dimensional pattern may be formed of a single wire or may be formed of a plurality of wires. 26 is a diagram of a two-dimensional pattern formed of a plurality of wires according to an exemplary embodiment of the present specification. Referring to FIG. 26, the two-dimensional pattern may be formed of a single wire 7. Alternatively, the two-dimensional pattern may be formed through connection of a plurality of wires 8a to 8j. Of course, a two-dimensional pattern may be formed by connecting a plurality of wires in a manner different from that shown in FIG. 26. For example, a body may be formed by forming a segment with a single wire and connecting adjacent segments through a bridge formed with a separate wire.

According to an embodiment, forming a three-dimensional pattern by forming a wire (S1300) may be forming a wire using a fixture. 27 is a diagram illustrating formation of a 3D pattern using a fixture according to an exemplary embodiment of the present specification. For example, the fixture 10e may include a rod 13e and a post 11e protruding therefrom. The wire 9 may be formed into a specific shape by the post 11e to form a three-dimensional pattern. As another example, the fixture 10f may include a groove 12f. The wire 9 may be formed into a specific shape by the groove 12f to form a three-dimensional pattern.

In FIG. 22, it is illustrated that a 3D pattern is formed after forming a 1D pattern and a 2D pattern. However, a 3D pattern may be formed without forming at least one of the 1D pattern and the 2D pattern. For example, it is possible to form a three-dimensional pattern directly without forming both a one-dimensional pattern and a two-dimensional pattern by forming this from the unshaped wire 9 using the fixtures 10e and 10f. Alternatively, after forming the 1D pattern, a 3D pattern may be formed immediately, and a 2D pattern and a 3D pattern may be formed without forming a 1D pattern, and various methods are possible.

According to an embodiment, the step of bonding the junction of the wire (S1400) may be bonding the junction of the wire formed in a two-dimensional pattern or a three-dimensional pattern. 28 is a diagram illustrating a connection of wires of a blood clot removal device according to an exemplary embodiment of the present specification. Referring to FIG. 28, the junction may be formed between adjacent cells.

Bonding of the joint is in various ways such as welding, brazing, soldering, adhesive, injection molding, mechanical locks, crimping, shrink tube, etc. It may be performed as, but is not limited thereto. Referring to FIG. 28, in the case of bonding by a welding method, additional materials other than the material constituting the wire may not be used. On the other hand, in the case of brazing, soldering, adhesive, injection molding, mechanical locking, crimping, and shrink tubing, an additional material 14 other than the wire material may be used. In this case, the additional material 14 may comprise a radiopaque material. When the additional material 14 includes a radiopaque material, the visibility of the blood clot removal device or body may be improved.

28 illustrates that four junctions are formed in one cell, but the number of junctions is not limited thereto. Also, not all joints have to be formed in the same way. For example, some joints may be formed by welding and other joints may be formed by injection molding.

According to an embodiment, the forming of the coating layer (S1500) may include coating at least a portion of the blood clot removal device with a radiopaque material. For example, at least some struts of the body may be coated with a radiopaque material. Alternatively, at least some wires of the body may be coated with a radiopaque material. In this case, even if the body is manufactured with a wire that does not contain a radiopaque material, the visibility of the blood clot removal device or the body can be secured by coating the radiopaque material thereafter. Alternatively, even if the body is manufactured with a wire including a radiopaque material, the visibility of the blood clot removal device or the body may be further improved through coating of an additional radiopaque material. Here, the coating layer may be formed through deposition such as sputtering or ion plating, but is not limited thereto.

According to another example of the manufacturing method according to the embodiment of the present specification, the body may be manufactured from a sheet. 29 is a flowchart of another example of a method of manufacturing a blood clot removing device according to an exemplary embodiment of the present specification, and relates to a method of manufacturing a body by processing a sheet. Referring to FIG. 29, the manufacturing method according to an embodiment of the present specification includes providing a first layer (S2100), forming an adhesive layer (S2200), forming a second layer (S2300), and Manufacturing a body by processing a sheet including one layer, an adhesive layer, and a second layer (S2400), and forming a coating layer on the body (S2500).

According to an embodiment, the step of providing the first layer (S2100) may be to provide a first layer having a flat plate shape. Here, the first layer may be or include a shape memory alloy such as nitinol, but is not limited thereto.

According to an embodiment, the step of forming the adhesive layer (S2200) may be coating the adhesive layer on the first layer through deposition such as sputtering or ion plating. Of course, the adhesive layer may be formed in other ways. The adhesive layer may increase bonding between the first layer and the second layer to be described later. The adhesive layer may include titanium, but is not limited thereto.

According to an embodiment, the step of forming the second layer (S2300) may be coating the second layer on the adhesive layer through deposition such as sputtering or ion plating. Of course, the second layer may be formed in other ways. The second layer may be or include a radiopaque material such as platinum, but is not limited thereto.

According to an embodiment, in the step of manufacturing a body by processing a sheet including a first layer, an adhesive layer, and a second layer (S2400), the sheet including the first layer, the adhesive layer, and the second layer is formed in a tube shape. After connecting, a three-dimensional pattern may be formed to manufacture a body. 30 is a diagram illustrating a method of manufacturing a body using a sheet according to an embodiment of the present specification. Referring to FIG. 30, a sheet including a first layer 15, a second layer 16, and an adhesive layer 17 for increasing bonding between the first layer 15 and the second layer 16 is shown. After connecting in the form of a tube, a 3D pattern may be formed thereto to manufacture the first body 11000. The 3D pattern may be formed through laser cutting, but is not limited thereto. In addition, although FIG. 30 illustrates that the first layer 15 is disposed outside the body and the second layer 16 is disposed inside the body, it may be formed in the opposite direction depending on the direction in which the first layer 15 is connected in the form of a tube. Although not shown, the same may be applied to the second body.

According to another embodiment, the step of manufacturing a body by processing a sheet including a first layer, an adhesive layer, and a second layer (S2400) is performed by cutting a sheet including the first layer, the adhesive layer, and the second layer. After forming a dimensional pattern, it may be connected in a tube shape to manufacture a body. In this case as well, since the above-described method may be applied except for the order of forming the pattern, a detailed description will be omitted.

According to an embodiment, the forming of the coating layer on the body (S2500) may include coating at least a portion of the blood clot removal device with a radiopaque material. For example, at least a portion of the body may be coated with a radiopaque material. Alternatively, at least some struts of the body may be coated with a radiopaque material. In this case, even if the body is manufactured with a layer that does not contain a radiopaque material, the visibility of the blood clot removal device or the body can be secured by coating the radiopaque material afterwards. Alternatively, even if the body is manufactured with a layer including a radiopaque material, the visibility of the blood clot removal device or the body may be further improved through coating of an additional radiopaque material. Here, the coating layer may be formed through deposition such as sputtering or ion plating, but is not limited thereto.

In the above description, a sheet including a first layer, an adhesive layer, and a second layer has been described, but the sheet may not include an adhesive layer in some cases, such as sufficient bonding between the first layer and the second layer. It may be a single layer rather than three layers, and may include three or more layers. In this case, some of the above-described steps may not be performed and may be appropriately modified. For example, when the sheet does not include an adhesive layer, the step of forming the adhesive layer (S2200) is not performed, and the step of forming the second layer (S2300) includes forming a second layer on the first layer. It can be a step. In addition, the step of manufacturing a body by processing a sheet including a first layer, an adhesive layer, and a second layer (S2400) is transformed into a step of manufacturing a body by processing a sheet including the first layer and the second layer. I can.

According to another example of the manufacturing method according to the embodiment of the present specification, the body may be manufactured from a tube. 31 is a flow chart of another example of a method of manufacturing a blood clot removing device according to an embodiment of the present specification, and relates to a method of manufacturing a body by processing a tube. Referring to FIG. 31, the manufacturing method according to an embodiment of the present specification includes providing a tube (S3100), manufacturing a body by forming a pattern on the tube (S3200), and forming a coating layer on the body. It may include (S3300).

According to an embodiment, the step of providing a tube (S3100) may be to provide a cylindrical tube. Here, the tube may include a shape memory alloy such as nitinol and/or a radiopaque material, but is not limited thereto.

According to an embodiment, the step of forming a body by forming a pattern on the tube (S3200) may be manufacturing a body by forming a three-dimensional pattern on the tube. The 3D pattern may be formed through laser cutting, but is not limited thereto.

According to an embodiment, the forming of the coating layer on the body (S3300) may include coating at least a portion of the blood clot removal device with a radiopaque material. For example, at least a portion of the body may be coated with a radiopaque material. Alternatively, at least some struts of the body may be coated with a radiopaque material. In this case, even if the body is manufactured with a tube that does not contain a radiopaque material, the visibility of the blood clot removal device or the body can be secured by coating the radiopaque material afterwards. Alternatively, even if the body is manufactured from a tube containing a radiopaque material, the visibility of the blood clot removal device or the body may be further improved through coating of an additional radiopaque material. The coating layer may be formed on at least a portion of at least one of the outer and inner surfaces of the tube. Here, the coating layer may be formed through deposition such as sputtering or ion plating, but is not limited thereto.

The above-described body manufacturing method is only an example, and a blood clot removal device may be manufactured in other ways. For example, some of the above-described steps may not be performed, or additional steps may be performed in addition to the above-described steps.

The blood clot removal device according to the embodiment of the present specification may be used in various ways. Hereinafter, some examples of a method of removing a blood clot using a blood clot removing device according to an embodiment of the present specification will be described.

According to an example of a method for removing a blood clot according to an embodiment of the present specification, the removal of a blood clot may be performed in consideration of characteristics of the blood clot. 32 is a flowchart of a method for removing a blood clot according to an embodiment of the present specification. Referring to FIG. 32, the method of removing a blood clot according to an embodiment includes arranging a blood clot removal device in a target area in a blood vessel (S4100), determining a characteristic of a blood clot (S4200), and determining an arrangement of the blood clot removal device. It may include the step (S4300) and the step (S4400) of recovering the blood clot removing device.

According to an embodiment, the step S4100 of arranging the blood clot removal device in the target area in the blood vessel may include disposing the blood clot removal device having a specific arrangement in the target area. Here, the specific arrangement may be a closed arrangement or an open arrangement. In addition, as described above, the blood clot removal device may be compressed in the catheter and delivered to the target area.

On the other hand, it may be advantageous for the thrombus removal device to be compressed into the catheter to have a closed arrangement compared to being compressed to have an open arrangement. Referring to FIGS. 3 and 4, in the case of the blood clot removal device 1000 having an open arrangement, a segment of one body is disposed so as to overlap with a segment of another body, whereas in the case of the blood clot removal device 1000 having a closed arrangement, one body It may be arranged so that the segment of the body is misaligned with the segment of the other body. Accordingly, the radial force of the thrombus removal device having the open arrangement may be greater than the radial force of the closed arrangement. That is, compressing the clot removal device having a closed arrangement may be more advantageous than compressing the clot removal device having an open arrangement.

According to an embodiment, the step S4100 of arranging the blood clot removal device in the target area in the blood vessel may include disposing the blood clot removal device so that the blood clot is located in a proximal area of the blood clot removal device. Here, the proximal region may be a region located in a proximal direction compared to the open invitation. Alternatively, the proximal region may be a region located in a proximal direction compared to the mouse structure.

According to an embodiment, the step of determining the characteristics of the blood clot (S4200) may be determining whether the blood clot is a percutaneous blood clot or a menstrual blood clot. Here, the characteristics of the blood clot may be determined through the shape of the blood clot removal device. In the case of a blood clot removal device having visibility, it is possible to determine whether the blood clot is a percutaneous blood clot or a menstrual blood clot by checking that the shape of at least a portion of the blood clot removing device is distorted or distorted. Referring to FIG. 2, in the case of a menstrual thrombosis, the distortion of a blood clot removal device may be relatively large compared to that of a contusion thrombosis.

If the blood clot removal device is not distorted or is distorted to less than a predetermined degree, the blood clot may be determined as a continuous blood clot. For example, the shape of the blood clot removal device is checked after a predetermined time has elapsed after the blood clot removal device is disposed in the target area, and if there is no distortion of the shape or is smaller than a predetermined degree, the blood clot may be determined as a lead blood clot. On the other hand, when the blood clot removal device is distorted or distorted to a predetermined degree or more, the blood clot may be determined as a menstrual blood clot. For example, if it is confirmed that the shape of the blood clot removal device is distorted or distorted beyond a predetermined degree even after a predetermined time elapses after the blood clot removal device is disposed in the target area, the blood clot may be determined as a menstrual blood clot. The predetermined time may be 5 to 10 minutes, but is not limited thereto. On the other hand, as described above, since the distinction between acupuncture points and acupuncture points may be somewhat arbitrary, it may also be somewhat arbitrary whether the shape must be distorted or distorted to determine the point of acupuncture.

According to an embodiment, determining the arrangement of the blood clot removal device (S4300) may be changing or maintaining the arrangement of the blood clot removal device. Here, whether the arrangement is changed or maintained may depend on at least one of an arrangement of a blood clot removing device disposed in the target area and a characteristic of a blood clot. As an example, when the blood clot removal device is disposed in the target area to have a closed arrangement and the blood clot is determined to be a lead blood clot, the arrangement of the blood clot removal device may be maintained in a closed arrangement. As another example, when the blood clot removal device is disposed in the target area to have a closed arrangement and the blood clot is determined to be a menstrual blood clot, the arrangement of the blood clot removal device may be changed to an open arrangement. As another example, when the blood clot removal device is disposed in the target area to have an open arrangement and the blood clot is determined to be a lead-blood clot, the arrangement of the blood clot removal device may be changed to a closed arrangement. As another example, when the blood clot removal device is disposed in the target area to have an open arrangement and the blood clot is determined to be a menstrual blood clot, the arrangement of the blood clot removal device may be maintained in an open arrangement.

According to an embodiment, the step of recovering the blood clot removal device (S4400) may be to recover the blood clot removal device out of the body. The arrangement of the blood clot removal device may be changed prior to retrieval of the blood clot removal device. For example, a blood clot removal device having an open arrangement may be changed to a closed arrangement before being recovered and then recovered outside the body. Of course, the blood clot removal device can be recovered outside the body without changing the arrangement.

33 is a flowchart illustrating an example of a method for removing a blood clot according to an embodiment of the present specification. Referring to FIG. 33, a blood clot removal device having a closed arrangement may be disposed in a target region in a blood vessel (S5100 ). Thereafter, as described above, based on the shape of the blood clot removal device, it may be determined whether the blood clot is a conjunctival blood clot or a menstrual clot (S5200). As a result of the determination, when the blood clot is a menstrual blood clot, the arrangement of the blood clot removal device may be changed to an open arrangement (S5301). Alternatively, as a result of the determination, when the thrombus is a constituent blood clot, the arrangement of the blood clot removal device may be maintained in a closed configuration (S5302). Thereafter, the blood clot removal device may be recovered (S5400) to remove the blood clot from the body.

The above-described method for removing blood clots is only an example, and a blood clot removing device may be used in other ways. In an embodiment, after disposing the blood clot removal device similar to a general blood clot removal device, the blood clot removal device may be recovered without changing the arrangement of the blood clot removal device regardless of the characteristics of the blood clot. Even in this case, the blood clot removal device according to the embodiment of the present specification including a plurality of bodies may be advantageous in removing blood clots compared to the conventional blood clot removal device including a single body. Conventional thrombus removal devices have had a case in which a single body is excessively stretched and the combined or captured thrombus is separated from the thrombus removal device in the case of recovering them. On the other hand, when the blood clot removal device includes a plurality of bodies, even if some of the bodies are stretched, the rest of the body is not stretched, and thus the whole body is stretched less than the blood clot removal device composed of a single body, thereby reducing the separation of the blood clot. In another embodiment, the characteristics of the blood clot may be determined before the blood clot removal device is placed in the target area, and the blood clot removal device having a specific arrangement may be disposed in the target area. For example, if the blood clot is determined to be a lead thrombosis, a blood clot removal device having a closed arrangement is delivered and placed in the target area, and if the blood clot is determined as a menstrual thrombosis, a blood clot removal device having an open arrangement is delivered to the target area. You will be able to place it on.

According to an embodiment, the method of removing a blood clot may further include performing a push and fluff operation. When the push and fluff operation is performed, the coupling of the blood clot removal device to the blood clot may increase. Alternatively, in the case of performing the push and fluff operation, the blood clot removal device may be more advantageous to remove the blood clot.

As an example, the push and fluff operation may be to provide relative movement between the catheter and the body by repeatedly moving at least one of the catheter and the body in a distal direction and a proximal direction when a body is removed from the catheter and placed in a blood vessel.

As another example, the push and fluff operation may be to repeatedly move at least one of the first body and the second body in a distal direction and a proximal direction to provide a relative movement between the first body and the second body. Here, the relative motion between the first body and the second body for the push and fluff operation may be smaller than the relative motion between the first body and the second body for changing the arrangement of the blood clot removal device. For example, the relative movement between the first body and the second body for the push and fluff operation may be a finer movement than the relative movement between the first body and the second body for changing the arrangement of the blood clot removal device. The push and fluff operation using the first body and the second body may be performed while the body is removed from the catheter. Alternatively, the push and fluff operation using the first body and the second body may be performed after removing the body from the catheter.

Hereinafter, another example of a blood clot removal device according to an embodiment of the present specification will be described.

3 and 4 show that two open invitations are formed in the blood clot removal device, but two open invitations are not necessarily formed in the blood clot removal device, and the number of open invitations can be appropriately adjusted. . For example, one open invitation or three or more open invitations may be formed in the blood clot removal device. Accordingly, the number of segments and/or mice included in the blood clot removal device may also vary.

34 and 35 are diagrams illustrating another example of a blood clot removal device according to an embodiment of the present specification. 34 and 35, the blood clot removal device 6000 according to the exemplary embodiment of the present specification may include one open invitation 6100. Alternatively, the blood clot removal device 6000 according to an embodiment of the present specification includes a first body 61000 and one segment 62100 including two segments 61100a and 61100b and one mouse structure 61200. The included second body 62000 may be included.

36 is a diagram of another example of a blood clot removing device according to an embodiment of the present specification. Referring to FIG. 36, the blood clot removal device 7000 according to an embodiment of the present specification may include three open invitations. Alternatively, the blood clot removal device 7000 according to an embodiment of the present specification includes a first body 71000 including four segments 71100a, 71100b, 71100c, and 71100d and three mouse structures 71200a, 71200b, and 71200c. And a second body 72000 including three segments 72100a, 72100b, and 72100c and two mouse structures 72200a and 72200b.

According to an embodiment, a distance in a circumferential direction between bridges included in a plurality of mouth structures of one body may be provided to be the same. For example, referring to FIG. 36, the distance in the circumferential direction between the first bridge 71202a and the second bridge 71202b is the distance in the circumferential direction between the second bridge 71202b and the third bridge 71202c. It can be provided to be the same.

According to an embodiment, a distance in a circumferential direction between bridges included in a plurality of mouse structures of one body may be determined based on the number of mouse structures. For example, the distance in the circumferential direction between the first bridges 11202a and 11202b and the second bridges 11202c and 11202d of the first body 11000 including the two mouse structures 11200a and 11200b of FIG. 8 is While 90°, between the first bridge 71202a, the second bridge 71202b and the third bridge 71202c of the first body 71000 including the three mouse structures 71200a, 71200b, 71200c of FIG. 36 The spacing in the circumferential direction of may be 60°.

Meanwhile, as described above, when the blood clot removing device is an open arrangement, a bridge of one body and a bridge of another body corresponding thereto may be provided to overlap each other. Referring to FIG. 36, the bridge 71202a of the first mouse structure 71200a of the first body 71000 and the bridge 72202a of the first mouse structure 72200a of the second body 72000 corresponding thereto are open. They can overlap each other in an array. In addition, the bridge 71202b of the second mouse structure 71200b of the first body 71000 and the bridge 72202b of the second mouse structure 72200b of the second body 72000 corresponding thereto overlap each other in an open arrangement. Can be.

According to an embodiment, a blood clot removal device including a first body and a second body in which cells are arranged to be offset from each other in an open arrangement may be provided. 37 is a diagram illustrating another example of a blood clot removing device according to an embodiment of the present specification. When comparing FIGS. 4 and 37, the blood clot removal device 1000 of FIG. 4 is disposed so that the cells of the first body 11000 and the second body 12000 overlap each other in an open arrangement, whereas the blood clot removal of FIG. 37 The device 8000 may be arranged so that cells of the first body 81000 and the second body 82000 are shifted from each other in an open arrangement. Here, the fact that the cells are arranged misaligned with each other may mean that a junction portion, which is a point where adjacent cells of one body meet, is arranged to be offset from a junction portion of another body. Alternatively, the fact that the cells are displaced from each other may mean that the junction part of one body is disposed inside the cell of the other body.

When the cells of the first body and the cells of the second body are disposed to be displaced from each other, the radial force in a region of the blood clot removal device may be reduced compared to a case where the cells are disposed to overlap each other. 4 and 37, the radial force in the segment region of the thrombus removal device 1000 of FIG. 4 may be greater than the radial force in the segment region of the thrombus removal device 8000 of FIG. 37. If the cells are displaced, it may be advantageous to compress the blood clot removal device into the catheter. Alternatively, the blood clot removal device may prevent damage to the blood vessel by applying excessive force to the blood vessel.

According to an embodiment, a length of a segment of one body and a length of a mouse structure of another body corresponding thereto may be the same. According to another embodiment, a length of a segment of one body and a length of a mouse structure of another body may be different. Here, the length of the segment may be a distance between the most recent cell and the most distal cell of the segment. In addition, the length of the mouse structure may be a distance between a most distal cell of a segment adjacent in a proximal direction from the mouse structure and a most proximal cell of a segment adjacent in a distal direction from the mouse structure.

38 is a diagram of a segment of a blood clot removal device according to an embodiment of the present specification and a length of a structure of a mouse. In FIG. 38, the ratio refers to the ratio between the length of the mouse structure of one body and the length of the segment of the other body corresponding thereto. For example, the length L1 of a mouse structure of one body and the length L2 of a segment of another body corresponding thereto may be the same. That is, the ratio between L1 and L2 may be 1:1. As another example, the length L3 of a mouse structure of one body may be greater than the length L4 of a segment of another body corresponding thereto. In this case, the size of the open invitation may be increased, and thus it may be advantageous to remove acupuncture points. Here, the ratio between L3 and L4 may be 1.2:1, but is not limited thereto. As another example, the length L5 of a mouse structure of one body may be smaller than the length L6 of a segment of another body corresponding thereto. Here, the ratio between L5 and L6 may be 0.8:1, but is not limited thereto.

According to an embodiment, the length of the segment positioned at the proximal position may be longer than the length of the segment positioned at the distal side. For example, the length of the first segment may be longer than the length of the second segment located distal to the first segment. Alternatively, the length of the most proximal segment of the blood clot removal device may be longer than that of other segments. Here, the most recent segment refers to a segment located at the most recent position in a closed arrangement among segments of a plurality of bodies included in the blood clot removal device.

39 is a diagram of a length according to a position of a segment of a blood clot removal device according to an exemplary embodiment of the present specification. 39 shows a blood clot removal device 9000 having a closed arrangement. Here, the blood clot removal device 9000 includes a first segment 91100a, a second segment 91100b, a third segment 91100c, and a first segment 92100a of the second body 92000 of the first body 91000. , May include a second segment 92100b. The length of the first segment 91100a of the first body 91000 may be longer than the length of the segments 91100b and 91100c located distal thereto. Alternatively, the nearest segment of the blood clot removal device 9000 is the first segment 91100a of the first body 91000, and the length of the nearest segment may be longer than that of other segments.

According to an embodiment, the segment may include a distal end extending outward of the thrombus removal device and extending along a length direction of the thrombus removal device or constricting inward of the thrombus removal device and extending along the length direction. In this case, interference between the relatively moving bodies is reduced, so that a change in the arrangement of the blood clot removal device, in particular, a change from a closed arrangement to an open arrangement can be made more smoothly. In the present specification, an end portion of a segment formed by spreading outward or constricting inward is referred to as an interference reduction mechanism.

The position at which the interference reducing structure is formed may be determined based on a direction of relative movement between the plurality of bodies when the arrangement of the blood clot removal device is changed from a closed arrangement to an open arrangement. For example, when the second body moves in a proximal direction relative to the first body when the thrombus removal device is changed from a closed arrangement to an open arrangement, the interference reducing structure may be a distal end portion of the segment of the first body and the second body. It may be formed on at least one of the proximal distal ends of the segment of the body.

An interference reducing structure may be formed in a body positioned inside of the plurality of bodies so as to extend inward in a radial direction. An interference reducing structure may be formed in a body positioned outside of the plurality of bodies so as to extend outward in a radial direction.

The interference reduction structure may be formed in all segments, or may be formed only in some segments.

According to an embodiment, the bridge may be provided to have a predetermined angle with the longitudinal axis of the blood clot removal device. 40 is a diagram illustrating a modified example of a bridge of a blood clot removal device according to an embodiment of the present specification, and relates to a bridge provided to have a lengthwise axis and a predetermined angle. Comparing FIGS. 4 and 40, the bridge of FIG. 4 may be provided parallel to the longitudinal axis, while the bridge of FIG. 40 may be provided to have a predetermined angle with the longitudinal axis.

Even when the bridge is provided to have a predetermined angle with the longitudinal axis, as described above, when the blood clot removing device is an open arrangement, the bridge of one body and the bridge of the other body corresponding thereto may be provided so as to overlap each other.

Bridges can connect adjacent segments in a variety of ways. The bridge may connect a cell located proximal to the bridge and a cell located distal to the bridge in various ways.

41 is a view of another modified example of a bridge of a blood clot removal device according to an embodiment of the present specification, and relates to a bridge connecting adjacent segments. According to an embodiment, the bridge 121202a may connect a distal end of a cell located proximal to the bridge 121202a and a proximal end of a cell located distal to the bridge 121202a. According to another embodiment, the bridge 121202b may connect a distal end of a cell located proximal to the bridge 121202b and a distal end of a cell located distal to the bridge 121202b. According to another embodiment, the bridge 121202c may connect a proximal end of a cell located proximal to the bridge 121202c and a proximal end of a cell located distal to the bridge 121202c. According to another embodiment, the bridge 121202d may connect a proximal end of a cell located proximal to the bridge 121202d and a distal end of a cell located distal to the bridge 121202d.

41 illustrates a bridge parallel to the longitudinal axis of the blood clot removal device, but the same may be applied to a bridge having a predetermined angle with the longitudinal axis.

As described above, the distal end of the body may be tapered. In this case, the distal end may be tapered toward the circumferential surface direction of the blood clot removal device. Alternatively, the distal end may be tapered toward a central axis in a longitudinal direction of the blood clot removal device.

42 is a diagram illustrating a tapering of a body of a blood clot removal device according to an exemplary embodiment of the present specification. 3 and 42, the proximal end portions 11300 and 12300 of the bodies 11000 and 12000 of FIG. 3 are tapered toward the circumferential surface direction of the thrombus removal device as they extend in the proximal direction, whereas the body of FIG. 42 ( As the proximal end portions of the 131000 and 132000) extend in the proximal direction, they may be tapered toward the longitudinal central axis of the thrombus removal device.

The size of the open area of the proximal distal end in the proximal direction formed when the proximal distal end of the body is tapered toward the circumferential surface as the proximal distal end of the body extends in the proximal direction is the central axis as the proximal distal end of the body extends in the proximal direction. It may be larger than the size of the open area formed when it is tapered toward the direction. Here, the blood clot may flow into or be captured into the blood clot removal device through the open area. Accordingly, tapering the proximal end portion of the body toward the circumferential surface direction may be advantageous for capturing thrombi, particularly for capturing acupuncture points, as compared to tapering toward the central axis direction.

In the above, the arrangement of the blood clot removal device or the formation of an open invitation has been mainly described through the relative movement between the plurality of bodies in the longitudinal direction, but the relative movement between the plurality of bodies in the circumferential direction, that is, a plurality of It is also possible to change the arrangement or form an open invitation through the relative rotation between the bodies.

According to an embodiment, the blood clot removal device includes a first body including a first cell and a second cell arranged along a circumferential direction, and a second body including a third cell and a fourth cell arranged along the circumferential direction. Can include. Here, the size of the second cell may be greater than the size of the first cell, and the size of the fourth cell may be greater than the size of the third cell. When the positional relationship between the first body and the second body is a first positional relationship in which the second cell and the fourth cell correspond to each other, an open invitation may be formed in the blood clot removal device. On the other hand, when the positional relationship between the first body and the second body is a second positional relationship in which the first cell and the fourth cell correspond to each other or the second cell and the third cell correspond to each other, a blood clot removal device There may not be an open invitation. The positional relationship between the bodies may be changed from the first positional relationship to the second positional relationship through a relative rotation between the first body and the second body, or may be changed from the second positional relationship to the first positional relationship. have.

Meanwhile, the apparatus for removing blood clots according to an exemplary embodiment of the present specification may be robust against deformation in a longitudinal direction and/or deformation in a radial direction.

43 to 45 are diagrams illustrating a modification of a blood clot removal device according to an exemplary embodiment of the present specification.

Referring to FIG. 43, when the blood clot removal device 20,000 configured as a single body is bent, the diameter in one area of the blood clot removal device 20,000 may decrease due to the deformation of the blood clot removal device 20,000 in the radial direction. I can. Here, the one region may correspond to a bent region of the blood clot removal device 20000.

On the other hand, the blood clot removal device including a plurality of bodies according to the exemplary embodiment of the present specification may be more resistant to deformation in a longitudinal direction and/or a deformation in a radial direction than a blood clot removal device composed of a single body. Hereinafter, this will be described with reference to FIGS. 44 and 45.

According to an embodiment, when a blood clot removing device including a plurality of bodies is bent, even if some of the plurality of bodies are deformed in a radial direction and their diameter is reduced, the remaining bodies of the plurality of bodies are not deformed to remove blood clots. The overall diameter of the device can be maintained over a certain level.

According to an embodiment, when a blood clot removing device including a plurality of bodies is bent, some of the plurality of bodies protrude to the outside of the remaining bodies, so that a diameter of the blood clot removing device as a whole may be maintained. For example, when the blood clot removal device including the first body 211000 and the second body 212000 is bent, one area of the second body 212000 is outside the circumferential surface of the first body 211000 It protrudes into and can maintain a diameter of a certain level or more throughout the blood clot removal device. Here, an area of the second body 212000 may protrude outward from a circumferential surface of the first body 211000 in the mouth structure of the first body 211000. Alternatively, one region of the second body 212000 may include a distal end region of the segment of the second body 212000. Meanwhile, the second body 212000 may be disposed inside the first body 211000 without being bent, but is not limited thereto.

46 and 47 are diagrams for the number of times of the blood clot removal device according to an embodiment of the present specification, and are diagrams illustrating the behavior of the blood clot removal device in a blood vessel model in which the shape of a blood vessel is reproduced.

Referring to FIG. 46, when the blood clot removal device 20,000 consisting of a single body passes through a curved blood vessel, the diameter in one area of the blood clot removal device 20,000 is changed by the deformation in the radial direction of the blood clot removal device 20,000. Can decrease. Accordingly, the blood clot removal device 20,000 may not cover the entire circumference of the blood vessel. That is, the blood vessel coverage of the blood clot removal device 20,000 near the bent blood vessel may be smaller than the blood vessel coverage near the straight blood vessel.

On the other hand, a blood clot removal device including a plurality of bodies according to an exemplary embodiment of the present specification may have greater vascular coverage than a blood clot removal device configured with a single body (especially near a curved blood vessel). Alternatively, the blood vessel coverage of the blood clot removal device including a plurality of bodies according to the exemplary embodiment of the present specification may be kept constant regardless of the bend of the blood vessel. Alternatively, the vascular coverage in the vicinity of the bent blood vessel of the blood clot removal device including a plurality of bodies according to the exemplary embodiment of the present specification may be substantially the same as the vascular coverage in the vicinity of straight blood vessels.

Referring to FIG. 47, the blood clot removal device 21000 including a plurality of bodies may maintain blood vessel coverage even when passing through a curved blood vessel.

As the blood clot removal device according to the exemplary embodiment of the present specification is robust against deformation in a longitudinal direction and/or in a radial direction, it may be advantageous for removing a blood clot. For example, when a blood clot removal device combined with a blood clot passes through a serpentine blood vessel, the blood clot removal device is excessively deformed in the longitudinal and/or radial direction (for example, when the diameter of one area of the body decreases, etc.) ) The blood clot may come off the clot removal device. Accordingly, if the blood clot removal device is robust to deformation in the longitudinal direction and/or in the radial direction, it will be possible to prevent or reduce the separation of the blood clot.

48 to 52 are diagrams of various embodiments of an apparatus for removing blood clots.

Referring to FIG. 48, a blood clot removal device 16000 according to an embodiment of the present specification includes a first body 161000, a second body 162000, a full tube 163000, a pull wire 164000, and a stopper 165000. ) And an anti-stretch wire (169300). The anti-stretch wire 169300 may connect a distal end of the first body 161000 and a distal end of the second body 162000. The distal end portion of the first body 161000 may be tapered toward its central axis. Accordingly, the first body 161000 may have a closed distal end portion. Open invitations 16100a and 16100b may be formed in the blood clot removal device 16000 in an open arrangement.

Referring to FIG. 49, a blood clot removal device 17000 according to an embodiment of the present specification includes a first body 171000, a second body 172000, a full tube 173000, a pull wire 174000, and a stopper 175000. ), baskets 178000a and 178000b, and an anti-stretch wire 179300. Open invitations 17100a and 17100b may be formed in the blood clot removal device 17000 in an open arrangement.

Referring to FIG. 50, the blood clot removal device 18000 according to the exemplary embodiment of the present specification may include a first body 181000 and a second body 182000. In an open arrangement, open invitations 18100a and 18100b may be formed in the blood clot removal device 18000.

51 and 52, the blood clot removal device 19000 according to the exemplary embodiment of the present specification may have a first arrangement and a second arrangement. Here, open invitations 19100, 19200, 19300, and 19400 may be formed in the blood clot removal device 19000 of the second arrangement. The blood clot removal device 19000 may include a body 191000. The open invitations 19100, 19200, 19300, and 19400 may be formed in the body 191000 of the blood clot removal device 19000.

The radius of the blood clot removal device may be changed according to the arrangement of the blood clot removal device. For example, referring to FIGS. 51 and 52, the radius of the thrombus removing device 19000 of the second array may be larger than the radius of the thrombus removing device 19000 of the first array. Here, the area in which the radius of the blood clot removal device 19000 is changed may correspond to the area in which the open invitations 19100, 19200, 19300, and 19400 are formed.

Depending on the formation of the open invitation, the radius of the blood clot removal device may be changed. For example, referring to FIGS. 51 and 52, as the open invitations 19100, 19200, 19300, and 19400 are formed in the thrombus removal device 19000, the radius of the thrombus removal device 19000 may increase.

The arrangement of the blood clot removal device may be repeatedly changed between the first arrangement and the second arrangement. For example, referring to FIGS. 51 and 52, the arrangement of the blood clot removal device 19000 may be repeatedly changed between the first arrangement and the second arrangement. Accordingly, the blood clot removal device can effectively remove the blood clot. For example, referring to FIGS. 51 and 52, as the arrangement of the blood clot removal device 19000 is repeatedly changed between the first and second arrangements, the radius of the blood clot removal device 19000 may also be repeatedly changed. And, through this, the combination of the blood clot removal device 19000 with the blood clot may increase.

The open invitation may be formed in an open form in one direction of the blood clot removal device. For example, the open invitation may be formed in an open form in a distal direction of the blood clot removal device. 51 and 52, the open invitations 19100, 19200, 19300, and 19400 through open invitations 19100, 19200, 19300, and 19400 formed in an open shape in the distal direction of the blood clot removal device 19000. A blood clot located at a more distal position may flow into the inside of the blood clot removal device 19000. As another example, the open invitation may be formed in an open shape in the proximal direction of the blood clot removal device. Through an open invitation formed in an open shape in a proximal direction of the blood clot removal device, a blood clot located proximal to the open invitation may flow into the inside of the blood clot removal device.

A plurality of open invitations may be formed in the blood clot removal device.

The plurality of open invitations may be formed along the length direction of the blood clot removal device. For example, referring to FIGS. 51 and 52, a second open invitation 19200 is formed on the distal side of the first open invitation 19100, and a third open invitation is formed on the distal side of the second open invitation 19200. An invitation 19300 may be formed, and a fourth open invitation 19400 may be formed distal to the third open invitation 19300.

The plurality of open invitations may be formed to be spaced apart from each other along the circumferential direction of the blood clot removal device. The plurality of open invitations may be formed at regular intervals in the circumferential direction. As a non-limiting example, referring to FIGS. 51 and 52, the first open invitation 19100 to the fourth open invitation 19400 may be formed at 90° intervals in the circumferential direction. When a plurality of open invitations (19100, 19200, 19300, 19400) are formed at different circumferential locations, the blood clot removal range in the circumferential direction increases compared to those formed at the same circumferential location, which may be advantageous for blood clot removal. .

Meanwhile, in FIGS. 51 and 52, it is shown that four open invitations 19100, 19200, 19300, and 19400 are formed in the blood clot removal device 19000, but the number of open invitations is not limited thereto. One or more open invitations may be formed.

The blood clot removal device according to an embodiment of the present specification may include a wire. The wire can be connected to the body. For example, referring to FIGS. 51 and 52, an end of the wire 192000 may be connected to a distal end region of the body 191000. Alternatively, the wire may apply an external force to the body or transmit the external force to the body.

Conversion between the arrangements of the blood clot removal device according to the exemplary embodiment of the present specification may be performed by a wire. For example, referring to FIGS. 51 and 52, a force in a proximal direction acts on the wire 192000, and a force acts in a proximal direction on a distal region of the body 191000, and accordingly, the blood clot removal device 19000 The arrangement of can be changed from the first arrangement to the second arrangement.

The blood clot removal device according to an embodiment of the present specification may include a tube. The tube can be connected to the body. For example, referring to FIGS. 51 and 52, the distal end of the tube 193000 may be connected to the proximal region of the body 191000. At least one area of the wire may be disposed inside the tube. For example, referring to FIGS. 51 and 52, a wire 192000 may be disposed inside the tube 193000. In this case, the distal region of the wire 192000 may be exposed to the outside of the tube 193000.

In the above, the configuration and features of the present invention have been described based on the embodiments, but the present invention is not limited thereto, and that various changes or modifications can be made within the spirit and scope of the present invention to those skilled in the art. It is obvious, and therefore, such changes or modifications are found to be within the scope of the appended claims.

1000, 2000, 3000, 4000, 5000, 6000, 7000, 8000, 9000, 10000, 11000, 12000, 13000, 14000, 15000, 16000, 17000, 18000, 19000, 20000, 21000: Blood clot removal device

Claims (20)

In the device for removing blood clots,
At least two first segments arranged along the longitudinal direction of the device and expandable in a radial direction, and disposed between at least two first segments adjacent in the longitudinal direction among the at least two first segments for thrombus engagement, and blood clots are introduced A first body comprising at least one first mouse structure for;
A second body including at least one second segment;
A first pull wire operably connected to the first body; And
Including; a second full wire operably connected to the second body,
The first body and the second body at least partially overlap along the length direction,
One of the first body and the second body is movable with respect to the other one of the first body and the second body,
The second segment may be aligned with the first mouse structure or with one of the at least two first segments due to the relative movement between the first body and the second body,
When the second segment is aligned with the first mouse structure, the first mouse structure is closed,
Opening the first mouse structure when the second segment is aligned with one of the at least two first segments
Blood clot removal device.
The method of claim 1,
A hollow is formed inside one of the first pull wire and the second pull wire, and at least some regions of the other one of the first pull wire and the second pull wire are disposed inside the hollow.
Blood clot removal device.
The method of claim 1,
The distal region of the other one of the first pull wire and the second pull wire so as to contact a distal end of one of the first pull wire and the second pull wire when the second segment opens the first mouth structure A stopper formed on the; further comprising
Blood clot removal device.
The method of claim 1,
A locking structure connected to a proximal end portion of at least one of the first pull wire and the second pull wire; further comprising,
The locking structure includes a first state allowing relative movement between the first pull wire and the second pull wire, and a second state limiting relative movement between the first pull wire and the second pull wire. doing
Blood clot removal device.
The method of claim 1,
The distal end portion of the segment positioned proximal among the at least two first segments is formed to extend outwardly of the device and extend along a distal direction.
Blood clot removal device.
The method of claim 1,
The proximal end portion of the second segment is formed to be constricted to the inside of the device and extend along the proximal direction.
Blood clot removal device.
The method of claim 1,
Each of the first body and the second body includes a proximal end portion tapered toward a circumferential surface direction of the device as it extends in a proximal direction.
Blood clot removal device.
The method of claim 1,
Each of the first body and the second body includes a proximal end portion tapered toward a central axis direction of the device as it extends in a proximal direction.
Blood clot removal device.
The method of claim 1,
The first mouse structure comprises a bridge connecting between the at least two first segments
Blood clot removal device.
The method of claim 9,
The bridge connects a distal end portion of a segment positioned proximal among the at least two first segments and a proximal end portion of a segment positioned distal among the at least two first segments.
Blood clot removal device.
The method of claim 9,
A front end is connected at a proximal region of the at least two first segments and a distal coupling point, and a rear end is connected at a distal region of the at least two first segments and a rear coupling point It is connected to the anti-stretch wire extending along the bridge; further comprising
Blood clot removal device.
The method of claim 11,
The length of the anti-stretch wire, characterized in that longer than the distance between the front coupling point and the rear coupling point
Blood clot removal device.
The method of claim 1,
Each of the first segment and the second segment includes a plurality of first cells and second cells.
Blood clot removal device.
The method of claim 13,
The first cell includes a first anti-stretch cell provided with a first anti-stretch strut,
The second cell includes a second anti-stretch cell provided with a second anti-stretch strut.
Blood clot removal device.
The method of claim 13,
When the second segment is aligned with one of the at least two first segments, the first cell and the second cell are provided to be displaced from each other.
Blood clot removal device.
The method of claim 1,
A basket connected to the distal end portion of the first body; further comprising
Blood clot removal device.
The method of claim 1,
At least one of the first body and the second body comprises a radiopaque material
Blood clot removal device.
The method of claim 1,
The length of the segment located at the most recent of the at least two first segments is longer than the length of the remaining first segment.
Blood clot removal device.
The method of claim 1,
The length of the first mouse structure, characterized in that longer than the length of the second segment
Blood clot removal device.
The method of claim 1,
When the second segment is aligned with the first mouse structure and the thrombus removal device is bent while the first mouse structure is closed, at least a portion of the second segment is outside the circumferential surface of the first mouse structure. Protruding into
Blood clot removal device.

Images