KR102219287B1 - Fermented pills for hangover prescription and its manufacturing method - Google Patents

Abstract

The present invention relates to fermented pills for hangover prescription and a manufacturing method thereof. The present invention provides the fermented pills for hangover prescription, wherein seonok complex strains in the form of complex powder or complex water is added to herbal medicine complex powder containing herbal medicines effective for hangover relief, which is a combination of Hovenia dulcis fruits, goji berries, and flower and roots of arrowroot, the mixture is kneaded with water and then fermented, and the fermented medicinal material is dried and crushed with kidney beans to be kneaded with glutinous rice paste and honey prepared in advance, and made into pills. Accordingly, it is possible to provide the fermented pills for a hangover prescription in a formulation capable of increasing the absorption rate of herbal medicinal ingredients effective for hangover relief.

Description

Fermented pill for hangover prescription and its manufacturing method {FERMENTED PILLS FOR HANGOVER PRESCRIPTION AND ITS MANUFACTURING METHOD}

The present invention relates to a fermented pill for hangover prescription and a method for manufacturing the same, and more particularly, a compound powder or zenok compound strain in the form of complex water is kneaded in a fermenter in a fermenter. For a hangover prescription that facilitates the absorption of herbal ingredients effective in improving hangovers due to fermentation by fermenting, drying the fermented drug, and pulverizing the fermented medicinal powder together with kidney beans, kneading and pulverizing previously prepared glutinous rice paste and honey. It relates to a fermented pill and a method of manufacturing the same.

Hangover is a general term for physical and mental discomfort that appears after drinking alcohol. Objective symptoms include perception, nausea, vomiting, drowsiness, headache, decreased motor skills, hematologic changes, and hormonal changes.

Alcohol, which is the main component of alcohol, exhibits various pharmacological effects when ingested. While it has positive effects such as increasing appetite, smoothing blood circulation, increasing body temperature, relieving stress, and inducing sleep, it has addiction, habitability, and dependence on alcohol. It has side effects such as becoming.

According to a survey by the Korea Institute for Health and Social Affairs, the frequency of drinking for adults over 20 years old in Korea was about 8 days per month, 11 days for men, and about 4 days for women. About 4.7%, 1 to 3 times a month, was 13.2%, which is a level of concern in terms of public health.

As such, modern people consume excessive amounts of alcohol that cannot be digested. The side effects of this are thirst, general malaise, fatigue, memory loss, bloating, vomiting, and diarrhea. The risk of getting sick is also increasing.

Alcohol is mainly absorbed by the stomach and small intestine, transferred to the liver, and metabolized. The absorption of alcohol through the blood can be minimized by decomposing up to 1/3 of the absorbed alcohol in the stomach by alcohol dehydrogenase (ADH).

About 90% of the alcohol reached in the liver is oxidized to acetaldehyde by ADH and then oxidized to acetic acid by acetaldehyde dehydrogenase (ALDH). The remaining about 10% of alcohol is metabolized to acetaldehyde by catalase. Since acetaldehyde, the primary metabolite of alcohol, is a highly reactive compound, it reacts with various other substances in the living body to increase toxicity and necrosis to hepatocytes, changes in microvascularity, changes in the structure and function of mitochondria in hepatocytes, and peroxidation of lipids. Let it. Acetaldehyde produces acetaldehyde-protein adducts and induces an immune response, leading to liver damage, and by producing lipid peroxide, it is involved in liver toxicity.

In addition, chronic alcohol consumption increases the concentration of triglyceride (TG) in the blood by inhibiting the oxidation of fatty acids, and thus the liver proceeds to fatty liver.

Acetaldehyde, which is essential in the metabolism of ingested alcohol, causes the most common cause of acute alcohol hangover, namely, nausea, vomiting, dizziness, thirst, lethargy, muscle pain, etc., causing socioeconomic loss due to the decline in work ability of the general public. do. For this reason, there has been a demand for foods aimed at relieving hangovers from the past. In addition to the traditional methods of using northern fish, bean sprouts, and honey, the market for professional hangover relievers is growing in recent years.

Patent Literature 1 discloses a composition for preventing and improving hangovers, including mistletoe extract, wolfberry extract, and gasoline extract, and provides a plant extract or herbal preparation of a composition for preventing and improving hangovers having excellent blood alcohol decomposition ability, at this time , Based on 100 parts by weight of mistletoe, the wolfberry is 60 to 90 parts by weight, and the gasiogalpi is 10 to 30 parts by weight, suggesting an optimized magnification of the composition for preventing and improving hangovers.

Materials effective for improving hangovers or relieving hangovers and various formulations including drinks, chocolates, and tablets have been suggested.

As another example, Patent Document 2 as a drink composition for relieving hangover, 50 to 60% by weight of chajeoncho, 5 to 10% by weight of wolfberry, 5 to 10% by weight of earthenware, 1 to 5% by weight of angelica, 1 to 5% by weight, %, 1-5% by weight of Cheonmundong, 1-5% by weight of mulberry, 1-5% by weight of mulberry leaves, 1-5% by weight of cinnamon, 1-5% by weight of thistle leaves, sorting, weighing, and washing the drug mixture in an extraction tank After adding purified water to 7 to 9 times (v/w) of the total weight, extract the hot water extract for 8 to 10 hours at 100 to 120°C, and then filter it to produce headache, vomiting, and thirst that appear as hangovers. It has the effect of suppressing damage to hepatocytes while alleviating it.

At this time, in general, the material effective for improving hangover or relieving hangover is formulated by extracting obtained after extraction at a temperature of 100 to 120°C or freeze-dried.

Accordingly, as a result of trying to improve the conventional problems, the present inventors kneaded together the herbal compound powder containing the herbal medicinal material effective for improving hangovers, and the seonok complex strain together, and fermented for hangover prescription that helps the absorption of ingredients effective in improving hangovers while performing the fermentation process. By providing a ring, the present invention has been accomplished.

Korean Patent Registration No. 10-1113603 (registered on Feb. 1, 2012) Korean Patent Registration No. 10-2011673 (registered on Aug. 12, 2019)

It is an object of the present invention to provide a fermented pill for hangover prescription.

Another object of the present invention is to provide a method of manufacturing a fermented pill for hangover prescription.

In order to achieve the above object, the present invention 1) the preparation step of the herbal compound powder containing the oriental medicinal herbs effective for improving hangover,

2) Kneading 0.1 to 0.5 parts by weight of the Sunok complex strain with water based on 100 parts by weight of the herbal compound powder, and fermenting it in a fermentor; and

3) It provides a method of manufacturing a fermented pill for hangover prescription comprising the step of drying the fermented medicinal material, kneading with kidney beans, pre-prepared grass and honey, and pilling.

In the manufacturing method of the present invention, the herbal medicinal material effective for the improvement of hangover in step 1) is preferably blended in a weight ratio of 1: 1: 1: 1.5, and more specifically, the above step The herbal compound powder of 1) is 1 to 44% by weight of the dermis, 10 to 12% by weight of Galgeun, 5 to 9% by weight of Galhwa, 5 to 9% by weight of Bokryeong, 5 to 9% by weight of Hongguk, 5 to 9% by weight of Earth jaw, It is composed of 5 to 9% by weight of peony, 5 to 9% by weight of pogongyeong, 5 to 9% by weight of wolfberry, 5 to 9% by weight, ginger 5 to 10% by weight, and 1 to 5% by weight of turmeric.

In addition, in the manufacturing method of the present invention, the herbal medicine composite powder in step 1) may be in the form of a mixed powder, or the drug obtained after separating the bath liquid after the drug bathing may be applied to the pulverized powder after drying.

The sunok complex strain of step 2) may be added in the form of fermented powder or fermented water.

At this time, the fermentation temperature of step 2) was solid fermentation at 31 to 41° C. for 24 to 72 hours.

Furthermore, the present invention comprises 100 parts by weight of herbal compound powder including oriental medicinal herbs effective for improving hangovers, which are mixed in a ratio of 1: 1: 1: 1.5 by weight of Gugija, Gugija, Galhwa, and Galgeun, 0.1 to 0.5 parts by weight of the Sunok compound strain A fermented pill for hangover prescription containing solid fermented fermented drug powder kneaded with water is provided in stick packaging.

According to the present invention, it is possible to provide a fermented pill for a hangover prescription that helps the absorption of an ingredient effective in improving hangover while kneading the seonok complex strain together with the herbal compound powder containing the herbal medicinal material effective for improving hangovers, and proceeding with the fermentation process.

1 is a photograph before and after sterilization of the herbal compound powder of the present invention,
2 is a result of lactic acid bacteria generation under the conditions of Example 1 of the present invention,
3 is a result of lactic acid bacteria generation under the conditions of Example 2 of the present invention,
4 is a result of generation of lactic acid bacteria according to time after solid fermentation using the Cheonggukjang fermenter of the present invention.

Hereinafter, the present invention will be described in detail.

The present invention 1) the preparation step of the herbal compound powder containing the oriental medicinal herbs effective for improving hangover,

2) Kneading 0.1 to 0.5 parts by weight of the Sunok complex strain with water based on 100 parts by weight of the herbal compound powder, and fermenting it in a fermentor; and

3) It provides a method of manufacturing a fermented pill for hangover prescription comprising the step of drying the fermented medicinal material, kneading with kidney beans, pre-prepared grass and honey, and pilling.

In the manufacturing method of the present invention, it is preferable to sterilize at 121° C. for 15 minutes in step 1) to remove harmful bacteria present in the herbal medicine complex powder.

The composition of the herbal medicinal material effective for improving hangover is based on Donguibogam prescription to treat hangover (headache, dizziness, thirst, fatigue, bad breath, etc.) and gastrointestinal disorders (vomiting, nausea, heartburn, diarrhea, etc.).

Specifically, Galhwahaeseongtang (Galhwa, Ginger, Baekbokryeong, Dermis, Hongguk, etc.), a representative prescription related to alcohol detoxification among Donguibogam, Daegeumeumja (Changchul, dermis, etc.) For reference, the ingredients are designed with foods that do not cause problems with the liver even if taken for a long time (kidney beans, brown rice, turmeric, honey).

Accordingly, the herbal medicinal material effective in improving hangovers of the present invention is preferably designed to contain as main components of Earth Ja, Gugija, Galhwa and Galgeun.

Earthja refers to a fruit or seed that has a fruit disease of a dulcis tree. It is used to help diuresis and treat soy sauce that has been damaged by alcoholism.

Goji is used to protect liver function and reduce the amount of cholesterol to prevent and treat arteriosclerosis.

Brown flower is a flower of arrowroot, which is picked and dried in the sun in late summer or early autumn. Buds or flowers that have just started to bloom, uneven, long oval or bell-shaped, 0.5-1.5cm long, 0.2-0.6cm wide, and 0.2-0.3cm thick. The calyx is dark green, and the bottom is connected, and the ends are split into 5, but the two are pointed as if they are joined together. The outer surface is covered with yellowish white hair. When viewed through a magnifying glass, there are 5 petals, male to purple, and wrapped in a calyx. There are 10 stamens, and the pistils are thin and long, bent, and fine hairs are attached. It has a slight peculiar smell and a little sweet taste. The browning relieves headaches, fever, and symptoms in which limbs cannot be left still due to the stuffiness and uncomfortableness of the chest, thirst, loss of appetite, abdominal distention, and vomiting caused by excessive drinking.

Brown root is not particularly limited as long as the roots of arrowroot Pueraria lobata Ohwi (bean and Leguminosae) are removed or the bark is removed. The galgeun gives the liquid tea composition for hangover relief the effect of lowering the concentration of alcohol in blood and alcohol in exhalation, and the effect of discharging alcohol in the body out of the body within a short time.

At this time, it is preferable that the earth jaw, goji ja, galwha and galgeun are blended in a weight ratio of 1: 1: 1: 1.5.

The herbal compound powder of step 1) of the present invention may further include ingredients that can help the above object in an oriental way, in addition to the herbal medicinal material effective in improving the hangover.

Thus, in the embodiment of the present invention, most preferably, the herbal compound powder is 1 to 44% by weight of the dermis, 10 to 12% by weight of Galgeun, 5 to 9% by weight of galhwa, 5 to 9% by weight of Bokryeong, 5 to 9% by weight of hongguk , Earthja 5 to 9% by weight, Peony 5 to 9% by weight, Pogongyeong 5 to 9% by weight, Gojija 5 to 9% by weight, Creation 5 to 9% by weight, Ginger 5 to 10% by weight and Turmeric 1 to 5% by weight Consists of

In the above, the dermis refers to a mature pericarp of a citrus unshiu Markovich or a similar plant.

Bokryeong is a medicinal herb that has the function of hydration and is effective in harmonizing the stomach and stomach (脾胃).

Peony has a soothing and analgesic effect, inhibits the formation of blood clots, increases myocardial blood flow, expands peripheral blood vessels, and acts as a coercion. In addition, it has been reported that it inhibits gastric acid secretion and prevents stress-related ulcers.

Pogongyeong is an outpost on the ground of dandelion, and is a material widely used in dermatology and inflammatory diseases. Dandelion extract relieves atopic dermatitis by inhibiting inflammatory substances, has antibacterial effect against Helicobacter pylori bacteria, which is present in the gastric mucosa and causes diseases such as chronic gastritis and duodenal ulcer, and removes active oxygen. It is known to protect the gastrointestinal mucosa. In addition, flavonoids, inulin, and fructo-oligosaccharides, which are ingredients of pogongyoung, are used as nutrients for Bifidobacterium, which is a beneficial bacteria in the intestine, and through this, they improve the intestinal flora and act in the intestines.

According to Donguibogam, Hongguk is recorded as a new country that makes blood flow well, digests food, and stops dysentery. It is reported that the recently revealed efficacy of hongguk lowers blood cholesterol levels and lowers blood pressure and blood sugar.

Creation is bitter and very tasty and warm in nature. It is a medicinal material that is effective in stopping vomiting and diarrhea, increasing body fluids, warming the stomach, helping digestion and improving appetite.

Ginger can activate metabolism and diuretic activity (aromatic geonwi), prevent proliferation of harmful microorganisms in the stomach, and implement a protective effect against alcoholic damage caused by the active ingredients.

Curcumin, the main component of turmeric, aids digestion and promotes bile secretion, helping to digest fat, reducing blood cholesterol and detoxifying the liver.

In addition, in the manufacturing method of the present invention, the herbal compound powder of step 1) is solidly fermented in the form of a solid powder, or a powder obtained by drying the drug separated from the bath liquid after the drug bath is used. Therefore, the present invention is compared with conventional liquid fermentation because it is introduced into the fermentation step as a herbal compound powder and proceeds with solid fermentation with the seonok complex strain.

In the manufacturing method of the present invention, the seonok complex strain of step 2) is a useful microbial group such as lactic acid bacteria extracted from traditional fermented foods such as kimchi, soy sauce, red pepper paste, soybean paste, cheonggukjang, salted fish, etc. , Because it is extracted from food, it is safe, so it is called Sunok-gyun (善玉菌) to distinguish it from useful microorganisms collected from the soil.

Seonokgyun is streptococcus (Streptococcus), Streptococcus par faecalis (Streptococcus faecalis), Lactobacillus ash FIG pillar's (Lactobacillus acidophilus), Lactobacillus bifidus (Latobacillus bifidus), Bacillus sub-blocks bus (Bacillus subtilus), Bacillus piece you Formis ( Bacillus licheniformis ), Bacillus polyfermenticu (Bacillus polyfermenticu ), Bacillus mesentericus (Bacillus mesentericus ), Saccharomyces cerevisiae (Saccharomyces cerevisiae ), Clostridium butyricum (Clostridium butyricum) Streptococcus faecium , Kloeckera apiculata , Saccharomyces chevalieri , Candida stellata , Saccharomyces obiformis/Vayanas oviformis /bayanus ), Saccharomyces rosei, Schizosaccharomyces pombe , Hanseniaspora uvarum , Saccharomyces , etc.

Accordingly, the sunok bacteria used in the present invention may be used by purchasing an extraction or used product, but may be introduced in the form of fermented powder or fermented water.

Preferably, with respect to 100 parts by weight of the herbal compound powder, 0.1 to 0.5 parts by weight, more preferably 0.2 to 0.4 parts by weight of the Sunok complex strain is kneaded with water, and fermented in a fermentor. At this time, when the amount of the complex strains of Sunok is less than 0.1 parts by weight, the beneficial bacteria activity is weak, and when it exceeds 0.5 parts by weight, there is a problem that the acidity is lowered.

The fermentation of step 2) of the manufacturing method of the present invention may be performed by solid fermentation or liquid fermentation at 25 to 50°C, more preferably, solid fermentation at 31 to 41°C for 24 to 72 hours in the embodiment of the present invention Explained as.

The term'solid state fermentation' is a method of fermenting by growing microorganisms after making a solid substrate contain a certain amount of water, and is also known as'solid state fermentation', and solid state fermentation is extraction and purification compared to liquid fermentation. It is easy to use and has the advantage of obtaining substances in nature of fermented products.

Solid fermentation is a new fermentation method that is completely different from bacterial fermentation in a liquid state or lactic acid bacteria fermentation that has been widely used so far.It is carried out at a temperature lower than the heating temperature of normal liquid fermentation, while Useful physiologically active substances can be obtained by inducing efficient biotransformation and using the breakthrough fermentation ability of fungi.

More preferably, as supported by the examples of the present invention, the activity temperature of lactic acid bacteria and Bacillus bacillus is performed at 31 to 41°C, more preferably 36 to 40°C, and 24 to 72 hours, more preferably 48 The solid fermentation conditions can be optimized for hours to 72 hours.

에서 15분 멸균처리에 의해 대장균군 및 일반세균을 제거된 결과를 확인할 수 있다. 1 is a photograph before and after sterilization of the herbal medicine composite powder of the present invention, with a sterilizer to remove harmful bacteria from the herbal medicine composite powder 121

Coliform group and general bacteria were removed by sterilization for 15 minutes.

Figure 2 is a result of the production of lactic acid bacteria under the condition of Example 1 of the present invention, the result of solid fermentation under the condition of Example 1 of the present invention in a situation where there is no general microorganism or E. coli immediately after sterilization, the number of lactic acid bacteria before and after sterilization is before and after sterilization. The number of lactic acid bacteria showed rapid proliferation up to 72 hours and gradually decreased after 96 hours, and when fermented powder was treated, the growth conditions of lactic acid bacteria proliferated more stably than before sterilization (S2) and decreased after 96 hours. In addition, it can be seen that the pH decreases after the initial inoculation both before and after sterilization.

3 is a result of lactic acid bacteria generation under the conditions of Example 2 of the present invention.

From the results of Figure 3, as a result of solid fermentation under the condition of Example 2 of the present invention, the number of lactic acid bacteria before and after sterilization showed rapid growth up to 96 hours and decreased after 96 hours, and the growth conditions of the lactic acid bacteria during treatment with fermented water were after sterilization ( S2) proliferated more stably than before sterilization and a tendency to decrease after 96 hours can be confirmed. In addition, regardless of the sterilization treatment, both the generation of lactic acid bacteria and the tendency to change the pH were reduced.

Figure 4 shows the results of the generation of lactic acid bacteria by time period after solid fermentation using the Cheonggukjang fermentor of the present invention, by inoculating fermented powder (S1-C) or fermented water (S4-C) of seonok complex bacterial water in the herbal medicine complex powder As a result of checking the number of lactic acid bacteria, Both the complex fermented powder and the fermented water showed rapid proliferation up to 96 hours and decreased after 96 hours.

In addition, the results confirm the number of Bacillus subtilis by the number of fermentation inoculated in Chinese medicine composite powder can Bacillus subtilis before sterilization is After slowly proliferation up to 72 hours, and sterilized by gradually increasing from 72 hours was found to be optimal in 96 hours [Table 10] . Thus, the results confirm the number of Bacillus subtilis was inoculated be combined fermentation powder and fermentation, it was confirmed the effect of stably proliferate to complex fermentation powder and fermented both 96 hours.

In addition, as a result of confirming the number of yeast bacteria by inoculating the herbal medicine complex powder with the complex fermented powder and fermented water, both the complex fermented powder and the fermented water gradually proliferated up to 96 hours and then reduced the results [not shown].

Furthermore, the present invention comprises 100 parts by weight of herbal compound powder including oriental medicinal herbs effective for improving hangovers, which are mixed in a ratio of 1: 1: 1: 1.5 by weight of Gugija, Gugija, Galhwa, and Galgeun, 0.1 to 0.5 parts by weight of the Sunok compound strain A fermented pill for hangover prescription is provided in a stick package, in which a solid fermented fermented drug powder is kneaded with water to a size of 4 to 5 mm.

The fermented pill for hangover prescription of the present invention is a product designed to increase the preference and absorption by providing a concentrated fermented product to consumers who are burdened with the smell or taste of herbs, and is a fermented food without any chemical additives or preservatives.

In addition, the fermentation pill for hangover prescription of the present invention is solid fermentation for 5 to 10 days using Sunok bacteria, lactic acid bacteria, Bacillus bacteria, etc., so that the ingredients of the material are well brewed, detoxification, and organic acids, vitamins and minerals are increased, Useful for hangover relief.

The fermented pill for hangover prescription of the present invention is taken with enough water at a time before and after drinking.

Hereinafter, the present invention will be described in more detail through examples.

The present examples are for explaining the present invention more specifically, and the scope of the present invention is not limited to these examples.

<Example 1> Preparation of fermented pill by solid fermentation using herbal medicine complex powder and fermented powder

The herbal compound powder shown in Table 1 below was sterilized at 121°C for 15 minutes in a sterilizer to remove harmful bacteria present in the powder, pulverized to a level of 60 mesh through a pulverizer, and mixed at a blending ratio.

With respect to 1,000 g of the herbal complex powder, 40 g of fermented powder as a strain of seonok was kneaded with water. The dough was put into a fermenter of Cheonggukjang and fermented at 41°C for 44 hours. At this time, the purchased and used fermented powder contains 12 types of lactic acid bacteria shown in Table 2 below, and yeast, kimchi lactic acid bacteria, and photosynthetic bacteria.

After the fermentation was completed, the fermented medicinal material was dried to a minimum loss of 8% on drying. The dried medicinal material was pulverized, and the powder passed through a 60 mesh sieve was selected.

Thereafter, the fermented medicinal powder was added to the prepared grass and honey, kneaded, and made to be made. The paste was prepared by adding water (powder: water in a weight ratio of 1: 4) to the kidney bean and brown rice powder, and heating it. 80 g of the prepared paste and 60 g of honey were added together and kneaded in a kneader, and then converted into a 5 mm ring size. . Then, the sugar was dried to a dry content of 8% or less at 50° C. or less, and then stick-packed.

<Example 2> Preparation of fermented pill by solid fermentation using herbal medicine complex powder and fermented water

The herbal medicine complex powder of Example 1 was used, and purified water 1.5 times the weight of the powder was added to an extractor, and heated at 100°C for 80 minutes. After the hot water, the medicinal material was taken out and separated from the hot water. The bath liquid (sugar content 55Brix) was concentrated in vacuo.

The above-mentioned medicinal herbs were taken out, put in a jar, and fermented water (200 ml of fermented water per 1 kg of oriental medicinal herbs) was mixed as a strain of sunok, and fermented at 38° C. for 72 hours in a Cheonggukjang fermentor. At this time, the purchased and used fermented water is a fermented product containing a large amount of zenok bacteria such as yeast and Namdu bacterium, and helps to generate a large amount of minerals. The yeasts include Saccharomyces sp ., Shizosaccharomyces sp. , Klureromyces sp ., Saccharomyces cerevisiae , and Saccharomyces cerevisiae. It contains Schizosaccharomyces pombe , Klureromyces lactis , and Saccharomyces boulardii .

The fermented medicinal material was dried at 60° C. and pulverized (200 mesh) with kidney beans. After the pulverization, glutinous rice paste and honey prepared in advance were added to the fermented medicinal powder, and kneaded and made to be formed. At this time, the size of the ring was 4 to 5 mm, and it was dried for 5 hours at a temperature of 60°C using a dragee inputted at an appropriate speed. The pills were weighed and stick-packed.

<Comparative Example 1> Liquid fermentation using herbal medicine complex powder and Sunok-gyun fermentation powder

The herbal medicine composite powder of Example 1 was prepared, purified water twice the weight of the herbal medicine composite powder was added, and hot water extraction was performed at 100°C for 80 minutes. After extraction, 125 ml of fermented water (Biotech) was added to the extract concentrated at 50° C. and 1 kg of herbal medicine, and liquid fermented at 50° C. for 72 hours in a fermentor.

<Experimental Example 1> Evaluation of production of lactic acid bacteria after solid fermentation

1. Evaluation before and after sterilization

In order to remove harmful bacteria from the herbal compound powder used in Example 1, sterilization was performed at 121°C for 15 minutes.

1 is a photograph before and after sterilization of the herbal compound powder of the present invention, the color changed to dark brown and the particles became softer than before sterilization, the coliform group was confirmed as negative, and the general bacteria were TNTC (Too Numerous To Count) before sterilization. On the other hand, it was not confirmed after sterilization.

2. Optimization of conditions through changes of lactic acid bacteria after solid fermentation

Add 9 ml of saline to 1 g of the sterilized fermented medicinal powder (fermented powder) of Example 1, shake, spread the lactic acid bacteria on MRS agar medium, and cultivate in an incubator at 37°C for 24h~48hr. Confirmed.

From the results in Example 1, confirming the number of lactic acid bacteria by inoculating the strains in fermentation seonok powder medicine in the composite powder of the result, the number of lactic acid bacteria before and after sterilization has showed a rapid proliferation up to 72 hours and slowly decreased after 96 hours.

In addition, it was confirmed that the growth conditions of lactic acid bacteria during fermentation powder treatment were more stable after sterilization (S2) than before sterilization, and a tendency to decrease after 96 hours.

From the results of Table 5, after inoculation of the fermented powder, a strain of Seonok, to the herbal medicine complex powder of Example 1, the pH change was confirmed. As a result, the pH decreased after the initial inoculation both before and after sterilization.

3. Fermented water treatment Changes in lactic acid bacteria during solid fermentation

9 ml of saline was added to 1 g of the sterilized fermented medicinal powder (fermented water) of Example 2, and shaken, and the lactic acid bacteria were smeared on MRS agar medium and cultured in an incubator at 37° C., and the state and number of the strains were checked.

From the results of Table 7 and Table 8, confirm the number of lactic acid bacteria by the number of fermentation inoculated in Chinese medicine composite powder a result, the number of lactic acid bacteria after sterilization before and has showed a rapid proliferation up to 96 hours was reduced after 96 hours, when the treated fermentation lactic acid The growth conditions of were confirmed that after sterilization (S2) proliferated more stably than before sterilization and decreased after 96 hours.

In addition, as a result of confirming the change in pH after inoculating the fermented water into the herbal medicine complex powder, it was confirmed that the pH decreased after the initial inoculation both before and after sterilization.

From the above results, as a result of solid fermentation under the conditions of Example 2 of the present invention in the absence of general bacteria or E. coli immediately after sterilization, the production and activity of lactic acid bacteria were confirmed. In addition, irrespective of the sterilization treatment, both the generation of lactic acid bacteria and the tendency to change the pH were reduced.

<Experimental Example 2> Evaluation of lactic acid bacteria activity after solid fermentation using a Cheonggukjang fermentor

In Experimental Example 1, the solid fermentation was carried out in the same manner, except that the solid fermentation was performed in the Cheonggukjang fermenter instead of the incubator, and fermentation was performed with fermented powder and fermented water in the herbal medicine complex powder, and the number of lactic acid bacteria was observed.

From the above results, the number of lactic acid bacteria was confirmed by inoculating fermented powder (S1-C) and fermented water (S4-C) in the herbal medicine complex powder. As a result , the number of lactic acid bacteria in both fermented powder and fermented water showed rapid growth up to 96 hours. Then it decreased.

From the above, when the fermented powder and fermented water were treated, the growth of lactic acid bacteria tended to proliferate stably.

<Experimental Example 3> Evaluation of Bacillus Bacillus activity after solid fermentation

It was carried out in the same manner as in Experimental Example 1, except that Bacillus Bacillus was spread on LB agar medium and cultured in an incubator at 37°C for 24 to 48 hours, and the state and number of the strains were checked.

From the results of Table 10, and confirm the number of Bacillus subtilis by the number of fermentation inoculated in Chinese medicine composite powder a result, the number Bacillus subtilis before sterilization showed that slow growth and 72 hours decreased since after sterilization is gradually increased from 72 hours 96 hours Was optimal, and then decreased.

In the above, the present invention has been described in detail only with respect to the described embodiments, but it is obvious to those skilled in the art that various modifications and modifications are possible within the scope of the technical idea of the present invention, and it is natural that such modifications and modifications belong to the appended claims.

Claims (7)

1) Preparation stage of herbal compound powder containing oriental medicinal herbs effective for improving hangover,
2) Kneading 0.1 to 0.5 parts by weight of the Sunok complex strain with water based on 100 parts by weight of the herbal compound powder, and fermenting it in a fermentor maintained at 25 to 50°C, and
3) Drying the fermented medicinal material, kneading with kidney beans, grass and honey prepared in advance, and converting
The Sunok complex strain of step 2) is introduced in the form of fermented powder,
Sunok complex strain in the form of fermented powder,
Streptococcus (Streptococcus) genus, Lactobacillus (Lactobacillus) genus, Bifidobacterium (Bifidobacterium) genus, yeast, including kimchi lactic acid bacteria and photosynthetic bacteria,
Herbal medicinal herbs effective for the improvement of hangover of step 1) are blended in a weight ratio of 1: 1: 1: 1.5,
The herbal compound powder of step 1) is 1 to 44% by weight of the dermis, 10 to 12% by weight of Galgeun, 5 to 9% by weight of Galhwa, 5 to 9% by weight of Bokryeong, 5 to 9% by weight of hongguk, 5 to 9% by weight of Jigsaw %, peony 5 to 9% by weight, pogongyeong 5 to 9% by weight, wolfberry 5 to 9% by weight, creation 5 to 9% by weight, ginger 5 to 10% by weight, and turmeric 1 to 5% by weight hangover Method of manufacturing fermented pills for prescription. delete delete The method of claim 1, wherein the herbal medicine complex powder of step 1) is a powder obtained by separating the bath liquid after the drug hot water, and then drying and pulverizing the obtained drug. delete The method of claim 1, wherein the fermentation of step 2) is solidly fermented at 31 to 41° C. for 24 to 72 hours. From the manufacturing method of any one of paragraphs 1, 4 and 6, the herbal medicine compound containing the oriental medicinal herbs effective for improving hangovers is formulated in a ratio of 1: 1: 1: 1.5 weight ratio of Gugija, Gugija, Galhwa and Galgeun 100 parts by weight of the powder, 0.1 to 0.5 parts by weight of a compound strain of Sunok are kneaded with water to form a solid fermented fermented drug powder.

Images