KR102216470B1 - Composition of Natural Substance - Google Patents

Abstract

The present invention provides a natural product composition containing ivy leaves and pelagium as active ingredients. According to the present invention, it is possible to provide a novel natural product composition that can be used as a medicine.

Description

Composition of Natural Substance

The present invention relates to a natural product composition, and more particularly, to a natural product composition that can be used as a medicine.

Natural products have been used in various ways in conventional medicine or food. Natural products are known to be more advantageous than synthetic products in terms of side effects and are preferred. The search for a new use of a single natural product is being made relatively actively, but the development of technology related to a natural product composition containing two or more natural products has not reached it. In the case of a natural product composition, it is necessary to develop a technology because an effect that is difficult to predict can be expected only from the effect of each natural product included in the composition.

On the other hand, ivy is an evergreen vine plant of the dicotyledonous family Arlesaceae, and Pelargonium is a perennial plant of the barren family, and is known as a medicinal plant native to South Africa (International Publication No. WO/2009/011499, etc.).

International Publication WO/2009/011499, 2009.1.22, Background technology

The problem to be solved by the present invention is to provide a novel natural product composition.

In addition, another problem to be solved by the present invention is to provide a use of a novel natural product composition.

The problems to be solved by the present invention are not limited to the problems mentioned above, and other problems that are not mentioned will be clearly understood by those skilled in the art from the following description.

The present invention provides a natural product composition containing ivy leaves and pelagium as active ingredients.
The natural products are ivy leaves and pelagium.

The ivy leaves are Hedera algeriensis, Hedera azorica, Hedera canariensis, Hedera colchica, Hedera helix, Hedera Hibernica (Hedera hibernica), Hedera maderensis (Hedera maderensis), Hedera nepalensis (Hedera nepalensis), Hedera pastuchowii (Hedera pastuchowii), and the group consisting of Hedera rhombea (Hedera rhombea) It may be one or more leaves selected from.

The pelargonium may be at least one selected from Pelargonium sidoides or Pelargonium reniforme.

The ivy leaf and pelagium may be an ivy leaf extract and a pelagium extract, or an ivy leaf and pelagium extract.

In addition, the present invention provides a use of the natural product composition of the present invention for the prevention, improvement or treatment of at least one selected from the group consisting of respiratory diseases, acute or chronic infections, diarrhea, and gastrointestinal diseases.

The respiratory disease may be one or more selected from the group consisting of upper respiratory tract infection, influenza virus infection, asthma, wheezing infant syndrome, chronic obstructive pulmonary disease, cold, and histocytosis of the lung.

The upper respiratory tract infection may be at least one selected from the group consisting of bronchitis, sinusitis, tonsillitis, and nasopharyngitis.

The infectious disease caused by the influenza virus may be at least one selected from the group consisting of bird flu, pandemic flu, and flu.

The gastrointestinal disease may be stomach pain.

In one embodiment, the natural product composition of the present invention may be for the prevention, improvement or treatment of respiratory diseases or gastrointestinal diseases.

In another embodiment, the present invention provides a use of the natural product composition of the present invention for preparing a preparation for preventing, improving or treating respiratory diseases or gastrointestinal diseases.

In another embodiment, the present invention provides a method for preventing, improving, or treating respiratory diseases or gastrointestinal diseases comprising administering the natural product composition of the present invention to a subject in need thereof.

In addition, the present invention provides an antitussive, expectorant, antihistamine, bronchoconstriction suppression, airway hypersensitivity suppression, bronchial obstruction suppression of lung tissue, or inflammatory cell infiltration of the natural product composition of the present disclosure.

In one embodiment, the natural product composition of the present invention may be used for antitussive, expectorant, antihistamine, bronchoconstriction suppression, airway hypersensitivity suppression, bronchial obstruction suppression of lung tissue, or inflammatory cell infiltration.

In another embodiment, the present invention provides a use of the natural product composition of the present invention for the preparation of antitussive, expectorant, antihistamine, bronchoconstriction suppression, airway hypersensitivity suppression, bronchial blockage of lung tissue, or inflammatory cell infiltration.

In another embodiment, the present invention is antitussive, expectorant, antihistamine, inhibiting bronchoconstriction, inhibiting airway hypersensitivity, inhibiting bronchial obstruction of lung tissue, comprising administering the natural product composition of the present invention to a subject in need thereof, or It provides a method of inhibiting inflammatory cell infiltration.

In addition, the present invention provides a pharmaceutical use of the natural product composition of the present invention.

In one embodiment, the natural product composition of the present invention may be a natural product pharmaceutical composition.

The pharmaceutical composition may be in the form of tablets, pills, powders, granules, capsules, suspensions, solutions, emulsions, syrups, injections, or suppositories.

In addition, the present invention provides a food use of the natural product composition of the present invention.

In one embodiment, the natural product composition of the present invention may be a natural product food composition.

The food may be in the form of candy, beverage, gum or tea.

The natural food composition may be a health functional food or a food additive.

The health functional food may be in the form of powder, granules, tablets, capsules, or beverages.

According to the present invention, it is possible to provide a novel natural product composition that can be used as a medicine or food.

Hereinafter, the advantages and features of the present invention, and a method of achieving them will become apparent with reference to the embodiments described below in detail. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in various forms different from each other, and only these embodiments make the disclosure of the present invention complete, and common knowledge in the technical field to which the present invention pertains. It is provided only to completely inform the scope of the invention to the possessor, and the invention is only defined by the scope of the claims.

The same reference numerals refer to the same components throughout the specification. Further, "and/or" includes all combinations of each and one or more of the recited elements.

The terms used in the present specification are for describing exemplary embodiments and are not intended to limit the present invention. In this specification, the singular form also includes the plural form unless specifically stated in the phrase. As used in the specification, "comprises" and/or "comprising" refers to the presence of one or more other components, steps, actions and/or elements, and/or elements, steps, actions and/or elements mentioned. Or does not exclude additions.

In the present specification,'treatment' means improvement or disappearance of a disease, a pathological condition, or a symptom. In addition,'improvement' is included in'treatment' and means that a pathological condition or symptom is improved. In addition,'prevention' is meant to include preventing a pathological condition or symptom from worsening or preventing transition to a disease.

At this time, prevention or improvement may be applied to food use, and treatment or prevention may be applied to pharmaceutical use. That is, in the case of food, it may be a'food for prevention or improvement', and in the case of a drug, it may be a'treatment or prophylactic drug' or a'treatment or prevention pharmaceutical composition'.

In addition,'prevention, improvement or treatment use','inhibition use','medical use','food use','prevention, improvement or treatment method','inhibition method','inhibition','prevention, improvement or Expressions such as'for treatment','pharmaceutical composition','food composition', and'use for manufacturing a formulation' refer to a use to which a natural product composition is applied even if there is a difference in expression format.

One embodiment of the natural product composition of the present invention includes ivy leaves and pelagium as active ingredients.

Ivy leaves are leaves of ivy, and ivy refers to a plant (Hedera spp.) of the Araliaceae family (Hedera), such as Hedera algeriensis, Hedera algeriensis, Hedera azorica, Hedera canariensis, Hedera colchica, Hedera helix , Hedera hibernica, Hedera maderensis, Hedera nepalensis, Hedera pastuchowii, or Hedera rhombea may be one or more selected from the group consisting of, but is not limited thereto.

Pelargonium (Pelargonium) refers to a plant of the pelagium species native to southern Africa, for example, Pelargonium sidoides (Pelargonium sidoides) or Pelargonium reniforme (Pelargonium reniforme) 1 selected from the group consisting of It may be more than a species, but is not limited thereto.

The ivy leaves may be included in one embodiment of the natural product composition of the present invention in an amount of 1 to 1000 parts by weight based on 100 parts by weight of pelagium.

The ivy leaves and pelagium may be dried, pulverized, and mixed, respectively, in the form of a mixture, or an extract form that is more convenient to use.

For example, the ivy leaf and pelagium may be an ivy leaf extract and a pelagium extract, or an ivy leaf and pelagium extract. That is, the active ingredient included in the composition may be a combination of an extract obtained by extracting each of ivy leaves and pelagium with a solvent, or an extract obtained by extracting ivy leaves and pelagium together with a solvent.

The extract includes a crude extract or a specific solvent-soluble extract (fraction), and such an extract may be in the form of a solution, a concentrate, a dried product, or the like. The dried product may be a lyophilized product or the like.

The ivy leaf extract may be obtained by extracting ivy leaves with water, alcohol, or a mixture thereof. Ivy leaves can be dry ivy leaves. For example, water, and a crude extract or crude extract obtained by extraction with one or more solvents selected from the group consisting of a straight chain or branched alcohol having 1 to 4 carbon atoms, an aqueous solution of a lower alcohol having 1 to 6 carbon atoms, preferably an aqueous propyl alcohol solution, It may be a soluble extract obtained by adding at least one solvent selected from the group consisting of an aqueous solution of isopropyl alcohol and saturated butyl alcohol. More specifically, after cutting the ivy leaves and washing with water to remove constrictions and drying, the group consisting of about 5 to 20 times water by weight and a straight chain or branched alcohol having 1 to 4 carbon atoms with respect to the dried ivy leaves At least one selected from, for example, water or 10 to 70% (v/v) aqueous methanol, ethanol aqueous solution, or water-saturated butyl alcohol may be used for reflux extraction. The extraction temperature may be 40 to 110 degrees Celsius.

The pelagium extract may also be obtained by extracting pelagium with water, alcohol, or a mixture thereof. The extraction solvent may be one or more selected from the group consisting of water and a straight chain or branched alcohol having 1 to 4 carbon atoms. The extraction site may be root, but not limited to this. For example, the pelagium extract may be obtained by filtration after extraction for 10 minutes to several days using water, ethanol, propanol, butanol or a mixture thereof as a solvent. At this time, extraction may be performed by heating and shaking (for example, 40 to 80 degrees Celsius). In addition, the pelagium extract may be in the form of a dry extract obtained by evaporating and drying after adding a carrier to a liquid extract.

In this way, a natural product composition may be prepared by extracting and mixing the ivy leaf extract and the pelagonium extract, respectively, or extracting the ivy leaf and pelagium together.

When alcohol is used as an extraction solvent in such an extract, the alcohol may be evaporated by heating or reducing the pressure separately in order to reduce the alcohol content in the composition. Specifically, the alcohol may be removed by evaporating under heated and reduced pressure conditions using a rotary evaporator or concentrating using a reduced pressure concentrator. At this time, the alcohol content in the extract may be preferably 1.0% by weight or less, more preferably 0.6 to 1.0% by weight or less.

The method for preparing such an extract is not limited thereto, and a commonly used extraction method may be applied. For example, hot water extraction, ultrasonic extraction, reflux cooling extraction, and the like may be applied.

It goes without saying that the ivy leaf and pelagium extract can be obtained by extracting the mixture of ivy leaf and pelagium with water, alcohol or a mixture thereof. At this time, each extraction method and extraction method of the same range can be applied.

The natural product composition according to an embodiment of the present invention may contain 0.1 to 99% by weight of an active ingredient based on the total weight of the composition, but is not limited thereto and may vary according to the condition of the user and the type and progression of the disease.

The natural product composition, which is an embodiment of the present invention, may be formulated in a more convenient form by further including an appropriate carrier, excipient, and/or diluent that is pharmaceutically or food acceptable in addition to the active ingredient.

Natural product compositions may be formulated and used in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, etc., external preparations, suppositories, and sterile injectable solutions, respectively, according to a conventional method. Carriers, excipients and diluents that may be included include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, Microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, magnesium stearate, and mineral oils. In the case of formulation, it is prepared using diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrants, and surfactants that are usually used. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and these solid preparations contain at least one excipient, such as starch, calcium carbonate, and sucrose. ) Or lactose (lactose), gelatin, etc. are mixed to prepare. In addition to simple excipients, lubricants such as magnesium, sterate and talc are also used. Liquid preparations for oral use include suspensions, liquid solutions, emulsions, syrups, etc. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as wetting agents, sweetening agents, fragrances, and preservatives may be included. . Preparations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized preparations, and suppositories. As the non-aqueous solvent and suspending agent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate may be used. As a base for suppositories, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like may be used.

In addition, the natural product composition may contain conventional food additives in addition to the active ingredients, and the food additives include chemical compounds such as ketones, glycine, sodium citrate, nicotinic acid, and cinnamic acid, reduced pigments, licorice extract, crystalline cellulose, high color pigments, guar Natural additives such as gums, sodium L-glutamate preparations, noodle-added alkalis, preservatives, and mixed preparations such as tar colorants are exemplified.

The natural product composition may be in the form of a beverage, and may contain, in addition to the active ingredient, various flavoring agents or natural carbohydrates, etc. as an additional component, such as a conventional beverage. Natural carbohydrates may be monosaccharides, disaccharides, polysaccharides, sugars, sugar alcohols, and the like. The disaccharide may be, for example, glucose, fructose, and the like, and the polarsaccharide may be, for example, maltose, sucrose, or the like. In addition, sugar may be, for example, dextrin, cyclodextrin, or the like, and sugar alcohol may be xylitol, sorbitol, erythritol, or the like. Flavoring agents can be natural and/or synthetic flavoring agents. The natural flavoring agent may be, for example, taumatin, stevia extract (eg, rebaudioside A, glycyrrhizin, etc.), and the synthetic flavoring agent may be saccharin, aspartame, or the like. The proportion of natural carbohydrates is generally about 1 to 20 g, preferably about 5 to 12 g, per 100 ml of the natural product composition in beverage form.

In addition to the above, natural product compositions include various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavors and natural flavoring agents, coloring agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters. , Stabilizers, preservatives, glycerin, alcohols, carbonates used in carbonated beverages, and the like. The proportion of these additives is generally selected from 0.1 to about 20 parts by weight per 100 parts by weight of the natural product composition.

Hereinafter, a form of mixing the dry extract will be described in more detail with respect to formulation of a natural product composition as an example. Such a form may be in the form of a powder, which is a form of a natural pharmaceutical composition. It goes without saying that the form of such a powder may be in the form of a powder, which is a kind of food composition.

3 liters of 30% (v/v) ethanol aqueous solution was added to 300 g of dried leaves of ivy (Hedera helix), extracted under reflux cooling for 6 hours, filtered and collected, and 2.5 liters of 30% (v/v) ethanol aqueous solution was collected in the residue. The mixture was heated and extracted again at 80 degrees Celsius for 3 hours to obtain a filtrate, which was mixed with the filtrate previously taken and concentrated under reduced pressure. After the azeotropic concentration was performed by adding 0.2 liter of water while the solvent was evaporated, the mixture was repeated twice, and the same amount of water was added to suspend the mixture, and then freeze-dried to obtain a powdery ivy leaf extract.

In addition, 2 times the amount of 35% (v/v) ethanol aqueous solution by weight is added to the root powder of pelagium (Pelagonium sidoides) and stored at room temperature for 20 hours. Thereafter, it was exuded with a 6% (v/v) aqueous ethanol solution corresponding to 4 times the amount of 35% (v/v) ethanol aqueous solution based on weight, and then filtered. The filtrate can be dried at 50 degrees Celsius under vacuum (18 mbar) to obtain a dried pelagium extract. A carrier such as mannitol may be mixed with such a dry extract.

A natural product composition according to an embodiment of the present invention may be prepared by a method such as obtaining a mixture by mixing the ivy leaf extract and the pelagium dried extract obtained by the above method. The mixture can be administered to a subject as a powder, a form of a pharmaceutical composition, for therapeutic purposes. In addition, the mixture may be used in food as a food additive in powder form. At this time, it goes without saying that the above-described carriers, additives, etc. can be additionally used and formulated into a more convenient form.

In addition, it is possible to refer to documents such as Remington's Pharmaceutical Science (latest edition), Mack Publishing Company, Easton PA, etc. for information on formulation.

On the other hand, the preferred dosage of the natural product composition as an embodiment varies depending on the condition and weight of the patient, the degree of the disease, the drug form, the route of administration and the duration, but may be appropriately selected by those skilled in the art. However, for a desirable effect, the active ingredient may be administered at 0.01 mg/kg to 10 g/kg per day, preferably 1 mg/kg to 1 g/kg. Administration may be administered once a day, or may be divided several times. Therefore, the dosage does not limit the scope of the present invention in any way.

The natural product composition can be administered to mammals such as mice, mice, livestock, and humans by various routes. All modes of administration can be expected, and may be administered through, for example, oral, rectal, or intravenous injection.

Ivy leaf or ivy leaf extract, one of the active ingredients contained in the natural product composition, exhibits an effect on respiratory diseases, etc., and its effect is mainly due to the mucolytic action of glycoside saponin, anticonvulsant action, and antitussive action. It is being judged. It is believed that the mucolytic action is due to the saponin properties of hederaglycoside, and the antispasmodic action, which is effective in inflammatory bronchi, is due to the parasympathetic inhibitory action of some glycosides. The antitussive effect is believed to be due to a mild sedative effect due to the central inhibition mechanism by affecting the cough center.

Pellagonium or Pellagonium extract, which is another active ingredient contained in natural product compositions, is used as a therapeutic agent for diarrhea, stomach pain, menstrual disorders, and liver disease. In addition, pelagium sidoides extract has been used to treat diarrhea or gastrointestinal syndrome. It is believed that this is mainly due to the astringent action of tannin, which is an ingredient. In addition, the root extract of pelagium sidoides can be used for the treatment of infections in the upper airway, such as rhinopharyngitis, tonsillitis, sinusitis, and brochitis. This effect is believed to be due to the antimicrobial effect of the pelagium sidoides extract. The extract may be an extract of roots and/or leaves. In addition, pelagium sidoides extract is useful for the treatment of acute or chronic infections because it affects immune regulation. These acute or chronic infections are effective in infections of the respiratory tract or otorhinolaryngitis, such as bronchitis, sinusitis, tonsillitis, and nasopharyngitis.

By combining the ivy leaves and pelagiums exhibiting the respective effects, the respective effects are increased, and a complex effect is exhibited.

That is, one embodiment of the natural product composition of the present invention may be applied to one or more prevention, improvement, or treatment purposes selected from the group consisting of respiratory diseases, acute or chronic infections, diarrhea, and gastrointestinal diseases.

Respiratory diseases, or acute or chronic infections, seem to be more effectively prevented, improved, or treated by the combined effects of pelagium's antimicrobial effect, immune modulating effect, and sedative effect of ivy leaves.

The respiratory disease may be, for example, one or more selected from the group consisting of upper respiratory tract infection, influenza virus infection, asthma, wheezing infant syndrome, chronic obstructive pulmonary disease, cold, and histocytosis of the lung.

The upper respiratory tract infection may be, for example, one or more selected from the group consisting of bronchitis, sinusitis, tonsillitis, and nasopharyngitis.

The infectious disease caused by the influenza virus may be, for example, one or more selected from the group consisting of bird flu, pandemic flu, and flu.

In addition, it seems that diarrhea or gastrointestinal diseases are more effectively prevented, improved, or treated by a combination effect such as the astringent effect of pelagonia and the soothing effect of the ivy leaf.

Gastrointestinal disease can be stomach pain.

Therefore, one embodiment of the natural product composition of the present invention may be for the prevention, improvement or treatment of respiratory diseases or gastrointestinal diseases. Specifically, an embodiment of the natural product composition of the present invention may be a natural product pharmaceutical composition for the treatment or prevention of respiratory diseases or gastrointestinal diseases. In addition, an embodiment of the natural product composition of the present invention may be a natural product food composition for improving or preventing respiratory diseases or gastrointestinal diseases.

In addition, one embodiment of the natural product composition of the present invention may be applied for the use of a preparation for preventing, improving or treating respiratory diseases or gastrointestinal diseases. In one embodiment, the use of the natural product composition of the present invention for manufacturing a therapeutic agent for respiratory diseases or gastrointestinal diseases may be provided.

In addition, an embodiment of the natural product composition of the present invention can be applied to a method of preventing, improving or treating respiratory diseases or gastrointestinal diseases including administering to a subject in need of administration. In one embodiment, a method for treating respiratory diseases or gastrointestinal diseases comprising administering the natural product composition of the present invention to a subject in need of administration may be provided. In this case, the subject is meant to include mammals including humans.

In addition, an embodiment of the natural product composition of the present invention can be applied for antitussive, expectorant, antihistamine, bronchoconstriction inhibition, airway hypersensitivity inhibition, bronchial obstruction of lung tissue, or inflammatory cell infiltration.

Through complex effects such as antimicrobial and immunomodulatory effects of pelagium and sedative effect of ivy leaves, more effectively antitussive, expectorant, antihistamine, bronchoconstriction suppression, airway hypersensitivity suppression, bronchial obstruction of lung tissue, or inflammatory cell infiltration It appears to have an inhibitory effect.

Accordingly, an embodiment of the natural product composition of the present invention may be used for antitussive, expectorant, antihistamine, bronchoconstriction inhibition, airway hypersensitivity inhibition, bronchoscopic obstruction of lung tissue, or inhibition of inflammatory cell infiltration. Specifically, an embodiment of the natural product composition of the present invention may be a natural product pharmaceutical composition for antitussive, expectorant, antihistamine, bronchoconstriction suppression, airway hypersensitivity suppression, bronchoblock obstruction of lung tissue, or inflammatory cell infiltration. In addition, an embodiment of the natural product composition of the present invention may be a natural product food composition for antitussive, expectorant, antihistamine, bronchoconstriction suppression, airway hypersensitivity suppression, bronchial obstruction suppression of lung tissue, or inflammatory cell infiltration.

In addition, an embodiment of the natural product composition of the present invention can be applied for the manufacture of a formulation for antitussive, expectorant, antihistamine, bronchoconstriction inhibition, airway hypersensitivity inhibition, bronchial obstruction of lung tissue, or inflammatory cell infiltration. In one embodiment, the use of the natural product composition of the present invention for the manufacture of a pharmaceutical formulation for antitussive, expectorant, antihistamine, bronchoconstriction inhibition, airway hypersensitivity inhibition, bronchial obstruction of lung tissue, or inflammatory cell infiltration is provided by the present invention. Can be.

In addition, an embodiment of the natural product composition of the present invention includes the step of administering to a subject in need of administration, including antitussive, expectorant, antihistamine, bronchoconstriction suppression, airway hypersensitivity suppression, bronchial obstruction of lung tissue, or inflammatory cell infiltration. It can be applied to suppression methods. In one embodiment, antitussive, expectorant, antihistamine, inhibiting bronchoconstriction, inhibiting airway hypersensitivity, inhibiting bronchial obstruction of lung tissue, or inhibiting inflammatory cell infiltration comprising the step of administering the natural product composition of the present invention to a subject in need thereof. A method can be provided. In this case, the subject is meant to include mammals including humans.

One embodiment of the natural product composition of the present invention having such an effect can be specifically applied for pharmaceutical use or food use. For example, an embodiment of the natural product composition of the present invention may be a natural product pharmaceutical composition or a natural product food composition.

The natural product pharmaceutical composition is one form included in the natural product composition, and since it is an expression that limits the use of the natural product composition to pharmaceutical use, the same contents as the natural product composition described above apply. Such natural pharmaceutical compositions may be in the form of tablets, pills, powders, granules, capsules, suspensions, solutions, emulsions, syrups, injections, or suppositories.

Natural product food composition is also a form included in the natural product composition, and since it is an expression that limits the use of the natural product composition to food use, the same contents as the natural product composition described above are of course applied.

The food may be a dietary supplement or a food additive. Food can be in the form of candy, beverage, gum or tea. The health functional food may be in the form of powder, granules, tablets, capsules, or beverages.

Natural food compositions can be variously included in foods such as beverages. Health functional food refers to a food manufactured (including processing) using raw materials or ingredients that have useful functionalities for the human body, and "functional" refers to a nutrient control or physiological function of the human body. It refers to obtaining useful effects for health purposes such as action.

The natural food composition may be added to food (including drinks) for the purpose of exhibiting the above-described effects. At this time, the amount of the natural food composition in the food can be generally added in an amount of 0.01 to 15% by weight of the total food weight, and the beverage composition is in a ratio of 0.02 to 10 g, preferably 0.3 to 1 g based on 100 ml. Can be added.

In order to avoid repetition of the description, the description of overlapping content is omitted, but matters mentioned in the composition, use, or method of the present invention are applied within the same range as long as they do not contradict each other.

Claims (4)

A natural product composition comprising ivy leaves and pelagium as active ingredients, and the natural products are ivy leaves and pelagium,
The active ingredient is a combination of an extract obtained by extracting each of the ivy leaf and the pelagium with a solvent, or a combination of the ivy leaf and the pelagium extracted with a solvent,
The solvent is a mixture of water and alcohol,
The alcohol is ethanol,
The pelagium is pelagium sidoides,
Natural product composition for preventing, improving or treating respiratory diseases. delete delete delete