KR102199487B1 - Ultrasonic Automatic Generating Apparatus capable of Noise Reduction and Anti-Contamination for Cell Culture - Google Patents

Abstract

The present invention relates to an automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination, wherein the automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination according to the present invention includes a needle for generating ultrasonic waves at the end. Ultrasonic probe; An upper housing part surrounding the circumference of the ultrasonic probe and including an upper housing having a cylindrical shape or a polygonal shape with an open lower side thereof; A lower housing unit disposed at a lower end of the upper housing unit and having at least one lower housing having a shape corresponding to the upper housing and having an open upper side; A housing transfer means for transferring the upper housing part and the lower housing part in a vertical and horizontal direction; And an outer case for simultaneously accommodating the upper housing part, the lower housing part, and the housing transfer means while fixing the support body for supporting the housing transfer means therein.
Accordingly, the present invention has a cylindrical housing that can close and seal the ultrasonic probe when generating ultrasonic waves in a solution containing stem cells or cells to be tested to promote cell culture, and cleaning the ultrasonic probe. There is an effect of providing an automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination by additionally providing a washing means.

Description

Ultrasonic Automatic Generating Apparatus capable of Noise Reduction and Anti-Contamination for Cell Culture}

The present invention relates to an automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination, and more particularly, an ultrasonic probe in the case of promoting cell culture by generating ultrasonic waves in a solution containing stem cells or cells to be tested. The present invention relates to an automatic cell culture ultrasonic generator capable of reducing noise and preventing contamination by further comprising a cylindrical housing that can be enclosed and sealed in close proximity and a cleaning means capable of cleaning the ultrasonic probe.

Recently, various efforts have been attempted to promote cell culture through physical and mechanical stimulation in addition to the method of treating growth factors or other cytokines in controlling various types of cell culture environments, including stem cells.

At this time, methods of giving physical and mechanical stimulation include electrical stimulation, ultrasonic stimulation, and the like, and it is known that the use of such stimulation may affect cell proliferation or differentiation.

In particular, the ultrasonic stimulation has a characteristic of allowing cells to grow well when an ultrasonic wave under a specific condition is irradiated to stem cells or cells.

1 is a view showing an ultrasonic generator for cell culture according to the prior art.

As shown in the drawing, the ultrasonic generator for cell culture according to the prior art includes an ultrasonic driving unit 1 in which a circuit for generating ultrasonic waves is built, and an ultrasonic probe 2 electrically connected to the ultrasonic driving unit 1 And a cell sample container 5 into which a needle 4 for generating ultrasonic waves formed at an end of the ultrasonic probe is inserted and filled with a cell solution to a predetermined depth.

Here, most of the ultrasonic generators according to the prior art are installed and used in a laboratory. However, when the ultrasonic probe is immersed in a cell solution and operated, the noise caused by the ultrasonic wave is very loud, and there is no means to reduce the noise. There was a problem in creating an experimental environment in which other experiments are impossible.

In addition, in the ultrasonic generator according to the prior art, since the cell culture unit and the ultrasonic probe are exposed to the air, there is a high possibility that the surface of the ultrasonic probe may be contaminated while passing through a plurality of experimenters. In the case of replacing the cell solution in the cell culture section, since the ultrasonic probe section must be replaced one by one, a new process is additionally required, making it difficult to efficiently conduct the cell culture experiment.

In order to solve this problem, a structure in which an ultrasonic generator is built using a thick outer enclosure has been attempted. However, even if the thick enclosure is used, when the ultrasonic probe contacts the cell solution, water vapor is generated on the surface of the solution when ultrasonic waves are generated. Therefore, there is a problem that the cell solution to be tested is contaminated when testing various cell samples because the tested cell sample remains inside the enclosure. In addition, it is possible to reduce only the noise level of the bass sound inside the enclosure, thereby reducing various frequency bands. There is a problem in that it does not have a reduction effect when the noise level increases according to the experimental conditions.

Therefore, there is an urgent need for a practical and applicable technology to reduce noise and prevent contamination in relation to an ultrasonic generator capable of cell culture.

Korean Patent Application Publication No. 10-2009-0008784 (January 22, 2009)

Accordingly, the present invention has been devised to solve the above problem, and the present invention is to close and seal the ultrasonic probe in the case of promoting cell culture by generating ultrasonic waves in a solution containing stem cells or cells to be tested. An object of the present invention is to provide an automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination by having a cylindrical housing and additionally providing a cleaning means for cleaning the ultrasonic probe.

An ultrasonic automatic generator for cell culture capable of reducing noise and preventing contamination according to an embodiment of the present invention includes: an ultrasonic probe having a needle for generating ultrasonic waves at an end thereof; An upper housing part surrounding the circumference of the ultrasonic probe and including an upper housing having a cylindrical shape or a polygonal shape with an open lower side thereof; A lower housing unit disposed at a lower end of the upper housing unit and having at least one lower housing having a shape corresponding to the upper housing and having an open upper side; A housing transfer means for transferring the upper housing part and the lower housing part in a vertical and horizontal direction; And an outer case for simultaneously accommodating the upper housing part, the lower housing part, and the housing transfer means while fixing the support body for supporting the housing transfer means therein.

In addition, when the lower end of the upper housing and the upper end of the lower housing come into contact with each other by the operation of the housing transfer means, the space surrounding the ultrasonic probe may be sealed, and noise generated through the ultrasonic probe may be reduced.

The housing transfer means is a vertical transfer means for performing a vertical transfer operation to seal or open a space surrounding the ultrasonic probe by transferring an upper housing part having the upper housing in a vertical direction from an upper side of the lower housing. and; A horizontal transfer operation to selectively place a lower housing corresponding to the upper housing by transferring the lower housing unit having one or more lower housings in a horizontal direction back and forth or to place and discharge a sample tube containing a cell solution Transfer means; And a transfer means support body that is supported and fixed to the outer case while supporting the operation of the vertical transfer means and the horizontal transfer means.

The vertical transfer means and the horizontal transfer means, respectively, a support panel for supporting the upper housing or the lower housing; A transfer module coupled to the support panel to perform a transfer operation; A linear guide part for guiding a linear reciprocating motion of the transfer module; And a linear drive motor for transmitting a driving force for operating the transfer module to the linear guide unit.

The ultrasonic probe is arranged to have a structure in which an ultrasonic generating needle formed at one end is inserted into the upper side of the upper housing and the other end is fixedly coupled to the upper end of the upper housing, and the ultrasonic probe by the vertical transfer means In the case of sealing the space surrounding the ultrasonic probe, the needle for generating ultrasonic waves of the ultrasonic probe may pass through the lower end of the upper housing and may be inserted to reach a predetermined depth inside the lower housing.

The lower housing unit having at least one lower housing includes: a lower housing for a sample tube for accommodating a sample tube containing a cell solution; A cleaning lower housing for cleaning the ultrasonic generating needle; And a lower housing mounting portion having a plurality of mounting grooves for mounting and fixing the lower housing for the sample tube and the lower housing for cleaning.

The lower housing for the sample tube and the lower housing for cleaning may include a cylindrical inner housing in which a wall surface is formed of a sheet material having a spring shape and various types of sound absorbing roles; And a cylindrical outer housing surrounding a wall surface of the inner housing, so that it is possible to absorb high-pitched noise as well as mid-bass noise generated by the ultrasonic probe.

The automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination according to an embodiment of the present invention sprays or cleans washing water onto an ultrasonic generator needle disposed inside an enclosed space comprising an upper housing and a lower housing for washing. A washing means having a plurality of washing lakes for removing contaminated water remaining after the water; And a drying means capable of injecting or discharging heated air into the enclosed space consisting of the upper housing and the lower housing for cleaning, and can wash and dry the ultrasonic generating needle, thereby preventing contamination. have.

An ultrasonic automatic generator for cell culture capable of reducing noise and preventing contamination according to an embodiment of the present invention includes: a washing water pump for supplying the washing water; And a heating heater for supplying the heated air.

An ultrasonic automatic generator for cell culture capable of reducing noise and preventing contamination according to an embodiment of the present invention includes an ultrasonic driving unit electrically connected to the ultrasonic probe to generate ultrasonic waves through the ultrasonic generating needle; And a main control unit for controlling an operation of the display unit displayed on the front surface of the outer case, an overall transfer operation, and the ultrasonic driving unit.

As described above, the present invention includes a cylindrical housing that can close and seal the ultrasonic probe when generating ultrasonic waves in a solution containing stem cells or cells to be tested to promote cell culture. There is an effect of providing an automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination by additionally provided with a washing means capable of washing.

1 is a view showing an ultrasonic generator for cell culture according to the prior art.
2 is a view showing the external configuration of an automatic cell culture ultrasonic generator capable of reducing noise and preventing contamination according to an embodiment of the present invention.
3 is a diagram schematically illustrating a configuration of the automatic ultrasonic generator shown in FIG. 2.
4 is a view for explaining the internal structure of the automatic ultrasonic generator shown in FIGS. 2 to 3 according to an embodiment of the present invention.
5 is a view for explaining a lower housing of the internal structure of the automatic ultrasonic generator shown in FIG. 4.
6 to 7 are views for explaining a comparison between the first embodiment and the second embodiment of the lower housing shown in FIG. 5.
8 is a view showing an ultrasonic probe constituting an automatic ultrasonic generator according to an embodiment of the present invention.
9 to 10 are views for explaining the operation of the automatic ultrasonic generator according to an embodiment of the present invention.

Since the description of the present invention is merely an embodiment for structural or functional description, the scope of the present invention should not be construed as being limited by the embodiments described in the text. That is, since the embodiments can be variously changed and have various forms, the scope of the present invention should be understood to include equivalents capable of realizing the technical idea.

Meanwhile, the meanings of terms described in the present invention should be understood as follows.

Terms such as "first" and "second" are used to distinguish one component from other components, and the scope of rights is not limited by these terms. For example, a first component may be referred to as a second component, and similarly, a second component may be referred to as a first component.

When a component is referred to as being "connected" to another component, it should be understood that although it may be directly connected to the other component, another component may exist in the middle. On the other hand, when it is mentioned that a certain component is "directly connected" to another component, it should be understood that no other component exists in the middle. On the other hand, other expressions describing the relationship between the constituent elements, that is, "between" and "just between" or "neighboring to" and "directly neighboring to" should be interpreted as well.

Singular expressions are to be understood as including plural expressions unless the context clearly indicates otherwise, and terms such as “comprise” or “have” refer to implemented features, numbers, steps, actions, components, parts, or It is to be understood that it is intended to designate that a combination exists and does not preclude the presence or addition of one or more other features or numbers, steps, actions, components, parts, or combinations thereof.

In each step, the identification code (for example, a, b, c, etc.) is used for convenience of explanation, and the identification code does not describe the order of each step, and each step has a specific sequence clearly in context. Unless otherwise stated, it may occur differently from the stated order. That is, each of the steps may occur in the same order as specified, may be performed substantially simultaneously, or may be performed in the reverse order.

All terms used herein have the same meaning as commonly understood by one of ordinary skill in the field to which the present invention belongs, unless otherwise defined. Terms defined in a commonly used dictionary should be interpreted as having the meaning of the related technology in context, and cannot be interpreted as having an ideal or excessively formal meaning unless explicitly defined in the present invention.

Hereinafter, exemplary embodiments of the present invention will be described with reference to the accompanying drawings.

FIG. 2 is a view showing the external configuration of an automatic cell culture ultrasonic generator capable of reducing noise and preventing contamination according to an embodiment of the present invention, and FIG. 3 schematically illustrates the configuration of the automatic ultrasonic generator shown in FIG. It is a drawing to do.

As shown in the drawing, the automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination according to an embodiment of the present invention includes an ultrasonic probe 100, an upper housing part 200, a lower housing part 300, It may be provided with a housing transfer means 400, and an outer case 500.

In more detail, the ultrasonic probe 100 is provided with a needle 110 for generating ultrasonic waves at one end, as shown in FIG. 8 to be described later, so that the needle 110 for generating ultrasonic waves is placed in a sample tube containing a cell solution. ) Can be precipitated to a certain depth and then ultrasonic waves can be generated.

In addition, the upper housing part 200 has a structure surrounding the circumference of the ultrasonic probe 100 by inserting the ultrasonic probe 100 into the upper part formed of a polygonal housing such as a cylindrical shape or a square with an open lower side. It may be formed as a housing 210.

Here, the upper housing 210 may be formed of a plurality of vertically separated housings instead of a single housing in order to replace parts with the ultrasonic probe 100 located inside during the experiment or to quickly respond to failure.

In addition, the lower housing part 300 is formed to have a structure disposed at the lower end of the upper housing part 200, as shown in the drawing, has a shape corresponding to the upper housing 210, and has an upper side One or more lower housings 310 and 320 having a polygonal housing such as a cylindrical shape or a quadrangular shape may be provided while being opened.

At this time, the one or more lower housings 310 and 320 may include a lower housing 310 for a sample tube that can accommodate a sample tube for testing a cell sample and a lower housing for cleaning that can be used when cleaning the ultrasonic probe ( 320) may be provided.

In an embodiment of the present invention, it is preferable that the upper housing part 200 and the lower housing part 300 are formed of a metal material made of aluminum.

In the embodiment of the present invention, the housing transfer means 400, first, has a structure facing the upper housing 210 constituting the upper housing part 200 in a vertical direction with respect to the lower housings 310 and 320. It can be guided to do the up-and-down linear reciprocating movement.

Next, the housing transfer means 400, the lower housing part so that the lower housing 310 for the sample tube and the lower housing for cleaning 320 can be selectively positioned corresponding to the upper housing 210. (300) It is possible to induce a horizontal transfer motion to move the entire body while performing a linear reciprocating motion with respect to the front and rear of the outer case 500.

A description of the operation process of the housing transfer means 400 will be described in detail with reference to FIGS. 9 to 10 to be described later.

In addition, in an embodiment of the present invention, the outer case 500, as shown in the drawing, while fixing the support body for supporting the housing transfer means 400 therein, the upper housing part 200 and the lower The housing part 300 and the housing transfer means 400 may be accommodated at the same time.

As described above, according to an embodiment of the present invention, primary noise reduction and contamination by accommodating the upper housing part 200, the lower housing part 300, and the housing transfer means 400 inside the outer case 500 It may have a preventive effect, and in addition, an experiment using ultrasonic waves through the ultrasonic probe 100 in an enclosed space by operating the upper housing part 200 and the lower housing part 300 up and down and forward and backward. By proceeding there is an effect that can significantly increase the noise reduction and pollution prevention effect compared to the closed structure using only the outer case 500.

4 is a diagram for explaining the internal structure of the automatic ultrasonic generator shown in FIGS. 2 to 3 according to an embodiment of the present invention, and FIG. 5 is a lower housing among the internal structures of the automatic ultrasonic generator shown in FIG. It is a figure for explaining.

As shown in Figs. 2 to 3 above, an ultrasonic automatic generator for cell culture capable of reducing noise and preventing contamination according to an embodiment of the present invention includes an ultrasonic probe having a needle 110 for generating ultrasonic waves at the end ( 100), an upper housing part 200 having a cylindrical upper housing 210 that surrounds the ultrasonic probe 100 and has an open lower side, and is disposed at the lower end of the upper housing part 200 and has an upper side Housing transfer means for transporting the lower housing unit 300 having one or more open cylindrical lower housings 310 and 320, and the upper housing unit 200 and the lower housing unit 300 in a vertical and horizontal direction (400), and an outer case that simultaneously accommodates the upper housing part 200, the lower housing part 300 and the housing transfer means 400 while fixing a support body supporting the housing transfer means 400 therein 500 may be provided.

Hereinafter, the internal structure embedded in the outer case 500 will be described in detail with reference to FIGS. 4 and 5.

First, referring to FIG. 4, in the ultrasonic generator according to the embodiment of the present invention, the lower end of the upper housing 210 and the upper end of the lower housings 310 and 320 face each other by the operation of the housing transfer means 400. When contacted, the space surrounding the ultrasonic probe 100 may be sealed, and noise generated through the ultrasonic probe 100 may be reduced.

At this time, in order to further perfect the sealing structure, a circular groove is formed along the upper edge of the lower housing 310 and 320 to correspond to the lower edge of the upper housing 210, and the lower end of the upper housing 210 O-rings made of rubber may be disposed in the grooves facing each other.

According to an embodiment of the present invention, as shown in FIG. 4, the housing transfer means 400 is shown to support the vertical transfer operation of the upper housing 210 and the horizontal transfer operation of the lower housing part 300. .

Here, the housing transfer means 400 may include a vertical transfer means 410 and a horizontal transfer means 420, as shown in the drawing.

More specifically, the vertical transfer means 410 transfers the upper housing part 200 including the upper housing 210 in a vertical direction from the upper side of the lower housing 310 and 320 to the ultrasonic probe 100 ) It is possible to perform a vertical transfer operation to seal or open the surrounding space.

In addition, the horizontal transfer means 420 transfers the lower housing unit 300 having one or more of the lower housings 310 and 320 in the front and rear horizontal direction to provide the lower housings 310 and 320 corresponding to the upper housing 210. It is possible to selectively arrange or perform a horizontal transfer operation to place and discharge a sample tube containing a cell solution.

In addition, as shown in the drawing, according to the embodiment of the present invention, the housing transfer means 400, while supporting the operation of the vertical transfer means 410 and the horizontal transfer means 420, the outer case 500 ) May be provided with a transport means support 430 that is supported and fixed.

In this case, an ultrasonic driving unit 600 on which an ultrasonic driving circuit for operating the ultrasonic probe 100 is mounted may be disposed on a predetermined portion of the transport means support 430.

That is, the automatic cell culture ultrasonic generator capable of reducing noise and preventing contamination according to an embodiment of the present invention is electrically connected to the ultrasonic probe 100 to generate ultrasonic waves through the ultrasonic generating needle 110. It can be seen that the ultrasonic driving unit 600 is provided.

In addition, as shown in FIG. 2 shown above, a display unit 501 displayed on the front of the outer case 500 and a main control unit 700 for controlling the overall transfer operation and the operation of the ultrasonic driving unit 600 are provided. It may be provided by being built in the front of the outer case 500.

According to an embodiment of the present invention, the vertical transfer means 410 and the horizontal transfer means 420 are respectively, as shown in Figure 4, support panels (401a, 401b), transfer modules (402a, 402b), Linear guide portions 403a and 403b, and linear drive motors 404a and 404b may be provided.

In more detail, the support panels 401a and 401b are for supporting the upper housing 210 or the lower housing 310 and 320, and, as shown in the drawing, the vertical transfer means 410 And a support panel 401a for supporting and fixing the upper housing 200 and a support panel 401b for supporting and fixing the lower housings 310 and 320 and constituting the horizontal transfer means 420.

In addition, the transfer modules (402a, 402b) are combined with the support panels (401a, 401b) to perform a transfer operation, and are formed identically to the vertical transfer means (410) and the horizontal transfer means (420). I can see that it is.

In addition, the linear guide parts 403a and 403b guide the linear reciprocating motion of the transfer modules 402a and 402b, and may include a screw guide rod penetrating the transfer modules 402a and 402b.

Therefore, when the screw guide rod is rotated by the linear driving motors 404a and 404b, the rotational motion is linearly transmitted by transmitting a driving force for operating the transfer modules 402a and 402b to the linear guides 403a and 403b. Can be converted into exercise.

Next, the lower housing unit 300 according to an embodiment of the present invention will be further described with reference to both FIGS. 4 and 5 as follows.

As shown in the drawing, the lower housing part 300 includes a lower housing 310 for a sample tube for accommodating a sample tube containing a cell solution, and a lower housing for cleaning 320 for cleaning the needle for generating ultrasonic waves. ), and a lower housing mounting portion 330 having a plurality of mounting grooves 331 and 332 for mounting and fixing the lower housing 310 for the sample tube and the lower housing 320 for cleaning.

Here, the sample tube lower housing 310 and the cleaning lower housing 320 constituting the lower housing part 300 may have a single structure as shown in FIG. 6 or a dual structure as shown in FIG. 7. Can be formed.

6 to 7 are views for explaining a comparison between the first embodiment and the second embodiment of the lower housing shown in FIG. 5, and FIG. 8 is an ultrasonic probe constituting an automatic ultrasonic generator according to an embodiment of the present invention. It is a diagram showing.

Hereinafter, embodiments of the lower housing according to the embodiment of the present invention will be described with reference to FIGS. 6 to 8.

In the automatic ultrasonic generator according to an embodiment of the present invention, as shown in the drawing, a needle for generating ultrasonic waves 110 formed at one end of the ultrasonic probe 100 is inserted into the upper side of the upper housing 210. The other end may be disposed to have a structure in a fixedly coupled form to the upper end of the upper housing 210.

In this case, according to the first embodiment as shown in FIG. 6, the lower housing 310 for the sample tube and the lower housing for cleaning 320 may each be configured as a housing having a single cylindrical shape.

In addition, according to the second embodiment as shown in FIG. 7, the lower housing 310 for the sample tube and the lower housing for cleaning 320 have a cylindrical inner housing 301 in which a wall surface is formed of a spring shape and a plate, respectively. , And a cylindrical outer housing 302 surrounding the wall surface of the inner housing 302, so that not only the bass noise generated by the ultrasonic probe 100 but also the high sound noise may be absorbed.

Here, when the inner housing 301 is formed of a plate material, it may be a plastic material or a metal material.

On the other hand, as shown in Figures 6 to 7, the ultrasonic automatic generator according to an embodiment of the present invention is to seal the space surrounding the ultrasonic probe 100 by the above-mentioned vertical transfer means 410. In this case, the needle 110 for generating ultrasonic waves of the ultrasonic probe 100 may pass through the lower end of the upper housing 210 and be inserted into the lower housings 310 and 320 to reach a predetermined depth.

In addition, a plurality of cleaning water is sprayed onto the ultrasonic generating needle 110 disposed in the enclosed space consisting of the upper housing 210 and the lower housing 320 for cleaning, or for removing contaminated water remaining after washing. A washing means 10 having a washing hose 11 and 12 may be provided.

Here, the washing hose may include an injection hose 11 for injecting washing water into the enclosed space and a discharge hose 12 for discharging the washed washing water to the outside, as shown in the drawing. It may be disposed in the lower housing 320 at once, and the injection hose 11 is disposed in the upper housing 210 as shown in FIG. 3 and discharged in communication with the outlet 12a in the lower housing 320 Hose 12 can be placed.

At this time, the nozzle part (nozzle hole) for spraying the washing water formed on the side of the lower housing 320 or the upper housing 210 in order to spray the washing water to the ultrasonic probe 100 is an inlet of the injection lake 11 (11a, 11b) By communicating with the ends and forming a diagonal line, it is possible to improve cleaning power.

In addition, a drying means 20 capable of injecting or discharging heated air into the enclosed space consisting of the upper housing 210 and the washing lower housing 320 may be additionally provided, and the drying means Reference numeral 20 may include a heated air inlet 21 for injecting heated air into the interior and a heated air outlet 22 for discharging the heated air into the lower housing 320.

In this way, the automatic generating device according to an embodiment of the present invention can wash and dry the ultrasonic generating needle 110 and thus have a pollution prevention function.

On the other hand, although not shown in the drawings, in order to perform the operation of the washing means 10 and the drying means 20 described above, the ultrasonic automatic generator for cell culture capable of reducing noise and preventing contamination according to an embodiment of the present invention is , A washing water pump (not shown) for supplying the washing water and a heating heater (not shown) for supplying the heated air may be further provided.

9 to 10 are views for explaining the operation of the automatic ultrasonic generator according to an embodiment of the present invention.

As shown in the drawing, the automatic ultrasonic generator according to the embodiment of the present invention includes a housing transfer means 400 for inducing a transfer operation of the upper housing part 200 and the lower housing part 300 to provide an ultrasonic probe ( Perform a vertical transfer operation to seal or open the space surrounding 100), selectively disposing the lower housings 310 and 320 corresponding to the upper housing 210, or passing a sample tube containing a cell solution and discharging It is possible to perform a horizontal transfer operation for this purpose.

At this time, as described above, the housing transfer means 400 may include a vertical transfer means 410 and a horizontal transfer means 420, and a detailed description of the same configuration described above in FIGS. 4 to 5 Is omitted.

9 is a view showing an operation of sealing the space surrounding the ultrasonic probe 100 by using the vertical transfer means 410 of the housing transfer means 400.

Here, the vertical transfer means 410 may include a support panel 401a, a transfer module 402a, a linear guide part 403a, and a linear drive motor 404a.

As shown in the figure, the support panel 401a can perform a transfer operation by combining the transfer module 402a with the transfer module 402a in a state in which the upper housing 210 is supported and fixed, and a linear reciprocating motion of the transfer module 402a A linear guide part 403a having a screw guide rod penetrating through the transfer module module 402a is required to guide it, and when the screw guide rod is rotated by a linear drive motor 404a, the linear guide part ( By transmitting a driving force for operating the transfer module 402a to 403a), the vertical transfer operation may be performed.

10 is a view showing a horizontal transfer operation for moving the lower housing corresponding to the upper housing 210 by using the horizontal transfer means 410 of the housing transfer means 400.

Here, the horizontal transfer means 420 may include a support panel 401b, a transfer module 402b, a linear guide part 403b, and a linear drive motor 404b.

As shown in the drawing, the support panel 401b is coupled to the transfer module 402b in a state in which the lower housing mounting portion 330 for mounting the lower housings 310 and 320 is supported and fixed to perform a transfer operation. In order to guide the linear reciprocating motion of the transfer module 402b, a linear guide part 403b having a screw guide rod penetrating through the transfer module module 402b is required, and the screw is provided by the linear drive motor 404b. When the guide rod is rotated, a driving force for operating the transfer module 402b is transmitted to the linear guide part 403b, thereby performing a front-rear horizontal transfer operation.

As described above, the present invention includes a cylindrical housing that can close and seal the ultrasonic probe when generating ultrasonic waves in a solution containing stem cells or cells to be tested to promote cell culture, and cleaning the ultrasonic probe. There is an effect of providing an ultrasonic automatic generator for cell culture capable of reducing noise and preventing contamination by additionally providing a cleaning means capable of doing so.

Although the present invention has been described in detail so far, it is clear that the embodiments mentioned in the process are only illustrative and not limiting, and the present invention is the technical idea or field of the present invention provided by the following claims. Within the range not departing from, it will be said that component changes to the extent that can be coped with equally fall within the scope of the present invention.

10: washing means
11,: washing hose (input hose)
12: washing hose (discharge hose)
20: drying means
21: heated air inlet
22: heated air outlet
100: ultrasonic probe
110: needle for ultrasonic generation
200: upper housing part
210: upper housing
300: lower housing part
301: inner housing
302: external housing
310: lower housing for sample tube
320: lower housing for cleaning
330: lower housing mounting part
400: housing transfer means
401a, 401b: support panel
402a, 402b: transfer module
403a, 403b: linear guide
404a, 404b: linear drive motor
410: vertical transfer means
420: horizontal transfer means
430: transport means support
500: outer enclosure
600: ultrasonic driving unit
700: main control unit

Claims (10)

An ultrasonic probe having an ultrasonic generating needle at the end;
An upper housing part surrounding the circumference of the ultrasonic probe and including an upper housing having a cylindrical shape or a polygonal shape with an open lower side thereof;
A lower housing unit disposed at a lower end of the upper housing unit and having at least one lower housing having a shape corresponding to the upper housing and having an open upper side;
A housing transfer means for transferring the upper housing part and the lower housing part in a vertical and horizontal direction; And
And an outer case that simultaneously accommodates the upper housing part, the lower housing part, and the housing transfer means while fixing a support body supporting the housing transfer means therein,
When the lower end of the upper housing and the upper end of the lower housing come into contact with each other by the operation of the housing transfer means, the space surrounding the ultrasonic probe is sealed, and noise generated through the ultrasonic probe is reduced,
The housing transfer means,
Vertical transfer means for performing a vertical transfer operation to seal or open a space surrounding the ultrasonic probe by transferring the upper housing portion having the upper housing in a vertical direction from the upper side of the lower housing;
A horizontal transfer operation to selectively place a lower housing corresponding to the upper housing by transferring the lower housing unit having one or more lower housings in a horizontal direction back and forth or to place and discharge a sample tube containing a cell solution Transfer means; And
And a transfer means support body supported and fixed to an outer case while supporting the operation of the vertical transfer means and the horizontal transfer means, and
The ultrasonic probe,
A needle for generating ultrasonic waves formed at one end is inserted into the upper side of the upper housing, and the other end is disposed to have a structure fixedly coupled to the upper end of the upper housing,
When the space surrounding the ultrasonic probe is sealed by the vertical transfer means, the ultrasonic generating needle of the ultrasonic probe passes through the lower end of the upper housing and is inserted so as to reach a certain depth inside the lower housing. ,
A lower housing unit having at least one lower housing,
A lower housing for a sample tube for accommodating a sample tube containing a cell solution;
A cleaning lower housing for cleaning the ultrasonic generating needle; And
A lower housing mounting unit having a plurality of mounting grooves for mounting and fixing the lower housing for the sample tube and the lower housing for cleaning; an ultrasonic automatic generator for cell culture capable of reducing noise and preventing contamination, comprising:
delete delete The method according to claim 1, wherein the vertical transfer means and the horizontal transfer means, respectively,
A support panel for supporting the upper housing or the lower housing;
A transfer module coupled to the support panel to perform a transfer operation;
A linear guide part for guiding a linear reciprocating motion of the transfer module; And
A linear drive motor that transmits a driving force for operating the transfer module to the linear guide unit; an ultrasonic automatic generator for cell culture capable of reducing noise and preventing contamination, characterized in that it comprises
delete delete The method according to claim 1, wherein the lower housing for the sample tube and the lower housing for cleaning, respectively,
A cylindrical inner housing in which the wall surface is formed of a sheet material having a spring shape and various types of sound absorbing roles; And
An automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination, characterized in that it is capable of absorbing high-pitched noise as well as bass noise generated by the ultrasonic probe by having a cylindrical outer housing surrounding the wall surface of the inner housing
The method of claim 7,
A washing means including a plurality of washing hoses for spraying washing water onto a needle for generating ultrasonic waves disposed in an enclosed space consisting of an upper housing and a lower housing for washing, or removing contaminated water remaining after washing; And
A drying means capable of injecting or discharging heated air into an enclosed space consisting of the upper housing and the lower housing for washing;
An automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination, characterized in that the needle for generating ultrasonic waves can be washed and dried to prevent contamination
The method of claim 8,
A washing water pump for supplying the washing water; And
A heating heater for supplying the heated air; an automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination, characterized in that it further comprises
The method according to claim 1,
An ultrasonic driving unit electrically connected to the ultrasonic probe to generate ultrasonic waves through the ultrasonic generating needle; And
A display unit displayed on the front of the outer case and a main control unit for controlling the operation of the ultrasonic driving unit and the overall transport operation; an automatic ultrasonic generator for cell culture capable of reducing noise and preventing contamination, further comprising

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