KR102181949B1 - Method for manufacturing twisted medical thread - Google Patents

Abstract

A twisted medical thread according to the present invention is characterized in that a main thread is twisted by rotating at least one end of both ends of the main thread extending to a certain length at a predetermined rotational speed. A manufacturing method of the twisted medical thread comprises: a first step of fixing the main thread to first and second fixing means spaced apart by the length of the main thread; and a second step of twisting the main thread by rotating at least one of the first and second fixing means at 1 to 5 rotations. According to the manufactured twisted medical thread according to the present invention, the main thread of the medical thread is twisted to have a large surface area and cross-sectional area, thereby enhancing contact force with the skin tissue and concentrating the traction force in the direction in which the main thread is inserted.

Description

Manufacturing method of twisted medical thread {METHOD FOR MANUFACTURING TWISTED MEDICAL THREAD}

The present invention relates to a twist-treated medical thread and a manufacturing method thereof, and in more detail, it is twisted as if twisting to increase the cross-sectional area, thereby enhancing the contact force and fixing force with the skin tissue, and the direction of the traction force in the direction in which the head office is inserted into the skin. It relates to a twisted medical thread that can be concentrated and a method of manufacturing the same.

Medical threads are applicable not only to surgical operations for therapeutic purposes, but also to procedures for cosmetic purposes such as removing wrinkles on the skin, and thus are used in medical operations and various procedures.

In the early days, medical threads were developed for the purpose of suturing the affected area after surgical operation, but in recent years, development for cosmetic and plastic surgery purposes is mainly made up. In particular, a procedure that is inserted into the skin and lifts aged skin to remove wrinkles. Development of medical threads for in-lifting procedures continues.

The material of a known medical thread is made of a material that melts such as polydioxanone, poly L Lactic Acid, or polycaprolacton, which is known as a collagen formation promoting substance, and lifts the skin by lifting it. It is common to gradually melt and disappear.

In most cases, a cog serving as an anchor point for holding the skin tissue is formed in such a medical thread, and the medical thread in which the cog is formed not only lifts the skin, but also can be well settled inside the skin.

As a prior art for a medical room equipped with a cog as described above, Korean Patent Publication No. 10-2006-0059142 (name of the invention: operating room for plastic surgery) has been disclosed.

The prior art is made of a metal, a polymer, or a biological material, in the operating room for plastic surgery having inclined protrusions continuously arranged along the longitudinal direction, the protrusions are manufactured in the form of conical barbs, and And it has flexible and elastic ends, the protrusion is located on one side or several sides of the thread cross-section, and proposes a cosmetic surgery operating room, characterized in that the inclined directions of the protrusions continuously alternate.

According to the prior art, a medical thread with a plurality of cogs (protrusions) that enhances the fixing force is proposed, but the head office (the body of the medical thread) has a simple thread-like shape to appropriately cope with the action of the repulsive force of the body, thereby providing traction. There was a problem that was difficult to maintain.

Therefore, the head office of the medical thread is not a simple thread, but a new and advanced form that can improve the function of medical thread by making it in a form that can improve surface area and strengthen traction, that is, a form that is twisted like a twist. There is a need to develop a twisted medical thread.

The present invention was conceived to overcome the problems of the above technology, and its main object is to provide a twisted medical thread capable of having a large surface area and cross-sectional area by twisting the head office of the medical thread as if twisting.

Another object of the present invention is to include a cog that is a protrusion capable of exerting a fixing force by holding the skin tissue on the surface of the head office subjected to the twist treatment.

Another object of the present invention is to provide a method of manufacturing a twisted medical thread capable of twisting by holding both ends of the head office with fixing means.

A further object of the present invention is to include a step capable of removing moisture remaining in the head office in a manufacturing method of twisting the head office and a step of removing germs on the surface of the head office.

In order to achieve the above object, the twisted medical thread according to the present invention is characterized in that the head office is twisted by rotating at least one end of both ends of the head office extended to a certain length at a predetermined rotational speed. .

In addition, the head office is characterized by having a plurality of cogs.

In addition, the method of manufacturing a twisted medical thread according to the present invention includes: a first step of fixing the head office to first and second fixing means spaced apart by the length of the head office; And a second step of twisting the head office by rotating at least one of the first and second fixing means at a rotation speed of 1 to 5 times.

Additionally, the manufacturing method includes a third step of drying the twisted head office at 30 to 40° C. for 30 minutes to 6 hours; And a fourth step of sterilizing the dried headquarters.

Twisted medical thread according to the present invention and method for manufacturing the same

1) By twisting the head office of the medical room to have a large surface area and cross-sectional area, the contact force with the skin tissue can be strengthened and the traction force can be concentrated in the direction in which the head office is inserted.

2) By forming a cog on the surface of the head office that has been treated with twist, it is possible to improve the lifting effect by reinforcing the fixing power to the skin tissue.

3) It is not only easy for the head office to control the number of turns that are twisted through the method of holding the ends of the head office with a fixing means and twisting,

4) The head office fixed to the fixing means is dried to remove residual moisture to prevent the head office from being deformed or decomposed by moisture, and the head office fixed to the fixing means is sterilized to insert the skin into the skin. And it is possible to prevent the concern that the skin tissue may be infected with bacteria by the procedure.

1 is a perspective view showing a basic embodiment of the twisted medical yarn of the present invention.
2 is a conceptual diagram illustrating a state in which a cog is formed in the thread of FIG. 1.
Figure 3 is a conceptual diagram showing a modified embodiment of Figure 2;
Figure 4 is a flow chart schematically showing a method of manufacturing a medical thread of the present invention.
5 is a plan view showing an embodiment of the manufacturing apparatus of the present invention.
Figure 6 is a flow chart showing a method of manufacturing the adjuvant of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. The accompanying drawings are not drawn to scale, and the same reference numerals in each drawing refer to the same elements.

1 is a perspective view showing a basic embodiment of the twisted medical yarn of the present invention.

As can be seen from FIG. 1, the medical thread of the present invention is twisted like the head office 10 is twisted, and in this case, the term'twisted' in the present invention generally encompasses processing such as twisting, knotting, winding, etc. In the above, it means that the head office 10 is twisted as if twisted and twisted, that is, torsion, like a screw forming a screw thread and a valley.

In other words, the twisted surface of the head office 10 is raised and recessed to be bent.In the present invention, a portion similar to the thread formed on the surface of the head office 10 is referred to as a'standing portion 11' and a portion similar to a bone Is referred to as a'recessed portion 12'.

At this time, the known screw has a short lead of a helix (the distance traveled in the axial direction when the screw is rotated one round), so that many threads and valleys are formed at narrow intervals, but the twisted head office 10 is Since the lead of the screw is longer than the known screw, it is possible to prevent the possibility that the head office 10 may be cut off due to excessive twisting by forming a small number of the standing parts 11 and the recessed parts 12 at wide intervals and being gently bent. It is possible.

In order to make the lead of the spiral of the main office 10 of the present invention longer than that of the known screw, the number of rotations of the main office 10 is set to 1 to 5 times during the twist treatment of the main office 10. do. Of course, it is not limited to the above-described rotational speed, and may be set to various rotational speeds according to the elastic limit of the main office 10.

For example, if the head office 10 is rotated four times, the head office 10 can be formed without breaking and the standing portion 11 and the recessed portion 12 may be formed, but if it is excessively twisted, such as 15 times and 20 times. If the head office 10 may be disconnected, it is possible to set the number of rotations according to the height of the elastic limit of the head office 10.

The material of the head office 10 is made of polydioxanone, which has a melting property like a known medical thread, or, furthermore, Poly L Lactic Acid or Polycaprolacton, which is known as a collagen formation promoting material. It is possible to consist of, but polydioxanone, polyL-lactic acid, and polarcaprolactone are flexible, so it is of course possible to form the standing portion 11 and the depression portion 12 by twisting treatment.

That is, when the main office 10 is made of the above-described material, it is preferable to twist the main office 10 at the rotational speed of 1 to 5 mentioned above in consideration of the elastic limit due to the material.

This method of twisting the main office 10 is to fix both ends of the main office 10 (the front and rear ends of the main office 10) with a fixing medium such as a jig or clamp, and then the fixing medium is fixed to the motor through the shaft 240. It is possible to rotate any one of the fixed media by connecting it to the motor and this will be described again below.

Here, the method of twisting the head office 10 is to rotate the fixed medium at one end of the head office 10 as a basic embodiment, but is not limited thereto, and the fixed medium at both ends of the head office 10 It goes without saying that it is also possible to twist the main office 10 by rotating it.

In summary, the medical thread of the present invention forms a standing part 11 and a recessed part 12 on the surface of the main office 10 by twisting the head office 10, so that the twist treatment is not performed, so that the medical thread or known Compared to the medical room equipped with the cog 13 of, it may have a more three-dimensional three-dimensional shape.

The medical thread of the present invention having such a structure can be mainly used for the purpose of lifting the skin for beauty rather than the purpose of suturing, and functions and actions will be described in comparison with the lifting thread provided with the known cog 13.

The known cog 13 expands the surface area of the main office 10 in the body to enhance contact and fixation, as well as provide a role as an anchor point, no matter how many along the length direction of the main office 10 Even though they are formed in various shapes and patterns, since each cog 13 is intermittently formed at regular intervals, it may play a role as an anchor point for ten minutes, but the elasticity of the headquarters 10 and the force and body inputted into the body It may be insufficient to sufficiently provide the traction force generated by the combination of the internal repulsion force.

On the other hand, in the twisted yarn of the present invention, the above-described standing portion 11 can serve as a protrusion like the cog 13, and the standing portion 11 is not intermittently formed, but the head office 10 Since it extends continuously from one end to the other end, of course, the cross-sectional area is wider than that of the known cog 13, so that it is possible to strengthen the contact force and the fixing force within the body.

Furthermore, since the standing part 11 extends in a twisted (twisted) shape rather than an ordinary pattern extending in parallel from one end to the other end of the main office 10, it is as if a vortex or eddy current occurs. Like the principle that the sum of the vector components of the force generated at the position is concentrated in the upward or downward direction, the sum of the vector components for the traction force of the body tissue can be concentrated and converged in the length (extension) direction of the headquarters 10 .

In other words, since the torsional stiffness of the body tissue in contact with the torsion pattern of the standing part 11 is provided to be consistently converged in the longitudinal direction of the main office 10, more reliable traction than the known cog 13 is provided. Establish the basis for guarantee.

2 is a conceptual diagram illustrating a state in which a cog is formed in the thread of FIG. 1.

Additionally, the main office 10 may include a plurality of cogs 13 on the surface.

In other words, by forming the cog 13 in any one of the standing portion 11 and the depression portion 12 of the twist pattern generated on the surface of the head office 10, an additional contact area is secured to increase contact force and fixing force within the body. Can be reinforced.

At this time, the cog 13 can be formed in a variety of known shapes and patterns.In FIG. 2, in Fig. 2, the cross-sections of both sides of the main office 10 are alternately extended from the front end to the rear end based on the length direction of the main office 10. The cog 13 was illustrated.

According to the cog 13 according to FIG. 2, it is possible to prevent the problem that the head office 10 is bent to one side in the living tissue due to the bilateral symmetrical structure while providing fixing force of the body tissue in addition to the function by the above-described twist pattern. Provides characteristics.

3 is a conceptual diagram showing a modified embodiment of FIG. 2.

It was said that the cog 13 described above may be protruded on the standing portion 11 or the recessed portion 12 of the main office 10, but in order to reinforce the above-described contact force and fixing force, the cog 13 should be formed on the standing portion 11 desirable.

As an example of this, FIG. 3 shows that the cog 13 is formed in the standing portion 11 of the head office 10 subjected to the twist treatment. As the cog 13 is formed along the standing portion 11, the depression portion ( 12) If the cog is also formed, it is possible to prevent the possibility that the height at which the cog 13 protrudes may be lowered.

In addition, the head office 10 having the cog 13 formed thereon as shown in FIG. 3 may also provide a characteristic capable of applying a stronger traction force in the longitudinal direction of the head office 10 since the fixing force to the skin tissue is improved.

At this time, although not shown in the drawings, the cog 13 formed on the standing portion 11 may be formed continuously along the extending direction of the standing portion 11 rather than intermittently formed in a plurality of cogs 13 at a predetermined interval.

In this case, the bottom area of the cog 13 may be equal to or smaller than the top area of the individual standing area 11, in other words, when the bottom surface of the cog 13 is wider than the top surface of the standing area 11, a deformed structure occurs. It is possible to provide a characteristic capable of further reinforcing the function and action of the above-described twisted (torsion)-treated standing portion 11 by this cog 13 while avoiding the problem of being a problem.

4 is a flow chart schematically showing a method of manufacturing a medical thread of the present invention, and FIG. 5 is a plan view showing an embodiment of the manufacturing apparatus of the present invention.

As can be seen from FIG. 4, the present invention provides a method of manufacturing the medical thread as well as the medical thread described above, and the manufacturing method of the medical thread according to the present invention is basically a step of fixing the head office 10 (S100) and the head office. It is possible to further include a drying step (S120) and a sterilization step (S130) in a state consisting of a step of rotating (S110).

That is, referring to Figures 4 and 5, the manufacturing method according to the present invention is a first step of fixing the above-described main office 10 to the first and second fixing means 210 and 220 spaced apart by the length of the main office 10 ( S100) and a second step (S110) of twisting the main office 10 by rotating at least one of the first and second fixing means 210 and 220 at 1 to 5 rotations.

This manufacturing method is basically implemented through a medical thread manufacturing apparatus (hereinafter referred to as a'manufacturing apparatus') capable of fixing as well as rotating the head office 10, and such a manufacturing apparatus uses currently known technologies and means. Although it is possible to have various structures based on the basis of the present invention, the basic structure is illustrated with reference to FIG. 5.

As can be seen from FIG. 5, the manufacturing apparatus may include detailed means within the chamber 100 while including the chamber 100 having a space for accommodating a medical room. In FIG. 5, only the chamber 100 is illustrated for the manufacturing apparatus, but the present invention is not limited thereto.

That is, the manufacturing apparatus of the present invention molds the main office 10, but when the cog 13 is provided in the main office 10, a molding means capable of molding and manufacturing up to the cog 13 (here, the main office 10 is the reference length In the case of longer molding, it is possible to include a cutting means for cutting to a reference length), a transfer means such as a conveyor belt for transferring the molded main office 10 to the chamber 100, and a chamber for picking up the transferred main office 10 ( It is possible to include a picking means such as a robot arm that moves to the fixing means 200 within 100), a drying means for drying the twisted head office 10, and a sterilization means for sterilizing after drying. At this time, the drying means and the sterilization means are means optionally provided in the present invention, and may be provided as a separate device from the chamber 100 or may be provided in the chamber 100.

The chamber 100 includes a space that can be sealed and opened based on a door mounted to be opened and closed on an upper surface. In this space, the main office 10 is accommodated, and a fixing means 200 for fixing and rotating the main office 10 is provided.

As can be seen from FIG. 5, in order to pursue the ease of mass production, the chamber 100 has a plurality of fixings corresponding to the number of the head office 10 in a state in which a space capable of accommodating a plurality of head offices 10 is secured. It has a means 200.

The fixing means 200 are located at both ends spaced apart by the length of the head office 10, and at this time, the first fixing means 210 located at one end, and the second fixing means 220 located at the other end. .

These first and second fixing means 210 and 220 only show a basic structure in FIG. 5. Basically, in a state provided with fixing parts such as tongs that can hold and fix each end of the main office 10, A rotating part 230 such as a motor connected via the shaft 240 is also provided.

That is, the molded head office 10 (optionally including the cog 13) is transferred to the chamber 100 by the transfer means, and then the head office 10 is picked up by the picking means, and the fixed part of the fixing means 200 If you move it to, you can pursue a way that the fixed part picks it up and fixes it.

The main office 10 fixed to the fixed part is rotated by driving the rotating part 230. At this time, the first and second fixing means 210 and 220 are rotated opposite to each other, and the first and second fixing means 210 and 220 may be rotated at the same time, or only one of them may be rotated.

The rotating part 230 can be set in various ways according to various basic properties such as the material and strength of the main office 10, but as described above, the case where the main office 10 is made of a currently well-known material such as PDO In the case of illustration, it is preferable to rotate, that is, twist treatment at 1 to 5 rotations to prevent breakage.

The rotated main office 10 may be picked by the above-mentioned picking means after the fixed part is opened, and then taken out of the chamber 100 and then transferred to a packing means for performing packing along the transfer means.

The medical thread produced through this process provides superior anchor points in the body and performs a more reliable traction function than the known technology having a cog 13 formed by a simple pattern at a specific part of the headquarters 10 as described above. Provides a characteristic that

In addition, the manufacturing method of the present invention may include a drying step (S120) and a sterilization step (S130) as mentioned above.

First, the drying step (S120) refers to a step of drying the twisted head office 10 in the chamber 100 or in a drying means separately provided as described above.

The drying means may be a device such as a hot air dryer or infrared dryer capable of setting the drying time and drying temperature, and the drying step (S120) through this drying means is a temperature that does not exceed the temperature at which the head office 10 can be deformed. Can proceed in scope.

Specifically, the drying means can dry the main office 10, but as described above, the main office 10 made of a material such as polydioxanone and polyL lactic acid is not deformed by heat. It is desirable to set the temperature.

In addition, the drying means is preferable to set the time condition in the time range of 30 minutes to 6 hours, which is if the drying step (S120) is shorter than 30 minutes, the main office 10 may not be sufficiently dried, and 6 hours This is because there is a possibility that the head office 10 may be exposed to heat for a long time and its original shape may be deformed.

This drying step (S120) is a step of preventing deterioration and deformation such as decomposition or contraction of the main office 10 by moisture by evaporating moisture contained or remaining in the main office 10.

Subsequently, the sterilization step (S130) refers to a step of sterilizing the dried head office 10 with a sterilization means that may be provided in the chamber 100 or may be provided as a separate device from the chamber 100.

The sterilization means may be a device such as an ultraviolet sterilizer or a high-pressure sterilizer capable of removing germs such as bacteria and microorganisms that may exist in the main office 10.

For example, when the sterilization means is an ultraviolet sterilizer, bacteria present in the main office 10 may be removed by irradiating ultraviolet rays in a short wavelength range of 10 to 100 nm having strong sterilization ability to the main office 10.

In summary, the sterilization step (S130) removes the bacteria present in the main office 10 that is inserted into the inner side of the skin to pull the skin, so that the area to which the main office 10 is applied during surgery and procedures using the main office 10 is You can avoid any concerns about being infected with fungi.

As another embodiment, as described above, the first and second fixing means 210 and 220 are simultaneously rotated and driven in opposite directions to twist the head office 10, wherein the first and second fixing means 210 and 220 are rotated differently. It is possible to rotate in water.

That is, the first and second fixing means 210 and 220 may be formed to have different degrees of twist treatment at the front and rear ends of the head office 10 by twisting the head office 10 at different rotational speeds.

For example, when the front end of the main office 10 is fixed by the first fixing means 210 and the rear end of the main office 10 is fixed by the second fixing means 220, the first fixing means 210 is twice When the second fixing means 220 is rotated and twisted four times, the rear end side of the main office 10 is twisted more than the front end side of the main office 10 so that there are many standing parts 11 and depressions 12 ) Can be formed.

In the case where the head office 10 of the present invention subjected to the twist treatment needs to apply a concentrated traction force to a specific area of the skin tissue, the side where the standing area 11 and the indentation area 12 of the head office 10 are formed a lot of the skin tissue It can be applied to various procedures by applying it to a specific area. In addition, when the cog 13 is formed on the surface of the head office 10 subjected to such a twist treatment, it is of course possible to concentrate the fixing force by strengthening the anchor point of a specific area.

As another embodiment, the first and second fixing means 210 and 220 described above may be moved a predetermined distance in the front-rear direction based on the length direction of the main office 10.

As such, the structure for moving the first and second fixing means 210 and 220 can also be implemented in various ways by currently known means, which is not shown in the drawing, but as an example, a sliding rail is provided under the fixed part and the rotating part 230. Is mounted, and each of the fixed part and the rotating part 230 can be connected to a sliding rail (for example, an LM guide driven by a ball screw) through a supporter. According to this structure, the rotating part 230 is It is possible to rotate and simultaneously move the fixed part and the rotating part 230 along the sliding rail back and forth along the longitudinal direction of the main office 10.

In the above-described twist processing step (second step S110) in a state in which the first and second fixing means 210 and 220 are provided to be movable, the first and second fixing means 210 and 220 are in the outer direction of the main office 10 It may include a step of pulling the main office 10 by being moved to (the direction in which the main office 10 is extended away from the main office 10).

That is, it is possible to first twist the head office 10 and then pull the head office 10 outward and then twist the head office 10 secondarily.

Specifically, when the head office 10 is primarily twisted, the number of revolutions at which the fixing means 200 rotates is referred to as the'first number of revolutions', and the first number of revolutions is the number of revolutions in which the head office 10 is cut off in the present invention. In order to prevent this, it is preferable that it is 1 to 2 times less than 1 to 5 times set as the basic number of rotations.

Subsequently, the step of pulling the main office 10 is a step in which the first and second fixing means 210 and 220 are moved to the outside of the main office 10 to pull the main office 10, as described above, the main office 10 pulled in a twisted state. ) Shows a resilience to return to its original length due to the basic elasticity possessed by materials such as polydioxanone described above.

Next, the step of secondary twisting the main office 10 is a step of rotating the fixing means 200 while the main office 10 is pulled, and at this time, the number of rotations at which the fixing means 200 rotates is'second rotation. As referred to as'number', the second rotational speed may also be 1 to 2 times less than 1 to 5 times set as the basic rotational speed as described above. In addition, even in this case, it is of course possible to set the number of rotations of the first and second fixing means 210 and 220 differently.

In summary, the head office 10 is twisted through a first rotational speed rotation step, a pulling step, and a second rotational speed rotation step, so that when the pull is released, it contracts by the restoring force, and the standing portion 11 and depression of the headquarters 10 The curvature formed by the portion 12 becomes clearer and more pronounced, and reinforcement of the traction force through an increase in the surface area can be achieved.

In addition, while pulling the head office 10, the head offices 10 that do not meet the elastic limit of a certain level are cut off, and the pulling step described above is likely to cause the tolerance of the elastic limit due to mass production of the head office 10 of the present invention. It can also provide a basis for preliminary identification of defective products that are easily broken in this presence.

In another embodiment, in the step of twisting the main office 10 in an environment in which the fixing means 220 can move back and forth along the longitudinal direction of the main office 10 (second step S110), the main office 10 A step of measuring the elastic limit of the head office 10 in a state pulled outward, and a step of restoring the head office 10 whose elastic limit was measured to its original length may be included.

The elastic limit is the boundary point of the strength of the force that can cause plastic deformation that remains permanently without recovering the deformation caused by an external force. The elastic limit is measured when the main body 10 is pulled in a disconnected or pulled state. It is possible to know the strength of the pulling force that may not be restored to the original length of the head office 10. At this time, the elastic limit can be measured in various ways such as pulling the head office 10 and measuring the tension appearing at the head office 10.

In other words, by pulling the head office 10 to measure the elastic limit and restore it again, a basis for twisting the mass-produced head office 10 to each elastic limit is provided, and the head office twisted up to the elastic limit ( 10) provides a property capable of reinforcing the traction force acting on the skin tissue through a large surface area and cross-sectional area, since it is possible to form as many standing portions 11 and indented portions 12 as possible.

As another embodiment, the third step (S120), which is the above-described drying step, may include a step (spray step) of spraying an auxiliary agent including fibroin to the head office.

In this case, the spraying step may be included during the drying step S120, that is, the drying step S120 may be divided into a first drying step and a second drying step before and after the spraying step.

Here, the first drying step, which is a step before the spraying step, is a step of evaporating the moisture remaining in the main office 10 before the auxiliary agent is sprayed so that the auxiliary agent is well adsorbed, and the second drying step after the spraying step is the main office ( This is a step of drying so that the auxiliary agent sprayed on 10) is adsorbed on the surface of the main office 10 and remains.

The adjuvant that remains on the surface of the headquarters 10 through this process includes fibroin, a material with biocompatibility, and fibroin is a fibrous protein composed of 18 amino acids such as glycine and alanine, which inhibits the generation of active oxygen. It can perform an anti-inflammatory action on the skin, and has physiological activity to promote skin regeneration. The manufacturing method of this auxiliary agent will be described later.

6 is a flow chart showing a method of manufacturing the adjuvant of the present invention.

As can be seen from FIG. 6, the auxiliary agent may be prepared through a fibroin manufacturing step (S200), a first material manufacturing step (S210), a secondary material manufacturing step (S220), and a supernatant removing step (S230).

First, the fibroin production step (S200) is 60 to 70 parts by weight of silk fibers, 20 to 30 parts by weight of water, and 10 to 20 parts by weight of sodium carbonate (Na ₂ CO ₃ ) mixed for 1 to 3 hours at 40 to 50°C, and then 60 It is a process of producing fibroin by pulverizing after drying at 70° C. for 5 to 7 hours.

Here, the silk fiber is a natural fiber that can be obtained from the cocoon, as is well known, and contains sericin and impurities in addition to fibroin. In the fibroin production step (S200), fibroin, a fibrous protein, can be obtained by removing such sericin and impurities. . In addition, water is a solvent that removes sericin and impurities, which are polar proteins, and disperses sodium carbonate, and sodium carbonate plays a role of assisting the removal of sericin and impurities by adjusting the pH of water. In addition, fibroin may be pulverized into a particle size in which an auxiliary agent can be sprayed in the spraying step described above.

Next, the first material manufacturing step (S210) is a process of preparing a primary material by mixing 60 to 70 parts by weight of fibroin and 30 to 40 parts by weight of polysorbate 80 for 30 to 60 minutes at 20 to 30°C. to be.

At this time, polysorbate 80 is a nonionic emulsifier capable of dispersing fibroin, and fibroin may be evenly dispersed in the primary material.

Subsequently, in the second material manufacturing step (S220), 70 to 80 parts by weight of the primary material and 20 to 30 parts by weight of sodium chloride are mixed, and then dispersed for 1 to 5 minutes at 25,000 to 30,000 rpm in a homogenizer, and then 5 to 20 μm This is a process of producing a secondary material by obtaining a filtrate filtered through a filter.

Here, sodium chloride is a material that can be electrolyzed and ionized, and serves to remove ionic impurities that may remain in the primary material. In addition, the secondary material, which is a filtrate filtered with a 5 to 20 μm filter, can be easily sprayed in the spraying step, but has a particle size capable of maintaining its own function.

Finally, the supernatant removal step (S230) is a mixture of 60 to 70 parts by weight of a secondary material, 20 to 30 parts by weight of an antioxidant material including hydroxyapatite and quercetin, and 10 to 20 parts by weight of ethanol. Then, after centrifugation at 3000 to 4000 rpm for 5 to 10 minutes, the supernatant is removed.

At this time, the ethanol serves to finally wash the secondary material. After centrifugation, a part of ethanol may be removed as a supernatant, and the remaining amount may be evaporated during the second drying step described above. In addition, the antioxidant is a substance capable of reinforcing the anti-inflammatory function of the adjuvant, and a specific method of manufacturing the antioxidant will be described later.

In summary, the adjuvant of the present invention can prevent the occurrence of inflammation in the skin tissue that can be damaged by the head office 10 inserted into the skin, including fibroin, and promotes skin regeneration around the head office 10 to lift It can help to maintain the shape of the skin.

Further, the above-described antioxidant is prepared including hydroxyapatite and quercetin, and may be specifically prepared through a first solution preparation step, a second solution preparation step, and a filtrate obtaining step. .

First, the first solution preparation step is a process of preparing a first solution by mixing 60 to 70 parts by weight of quercetin and 30 to 40 parts by weight of dimethyl sulfoxide at 20 to 30°C for 10 to 30 minutes.

Here, quercetin is a plant-derived flavonoid that can effectively remove free radicals, thereby realizing the antioxidant function of an antioxidant. In addition, since dimethyl sulfoxide acts as a dispersion medium for dispersing quercetin, it is a substance that can help relieve pain that can be followed by insertion of a medical thread by performing a pain relief function in vivo.

Next, the second solution preparation step is to prepare a second solution by mixing 50 to 60 parts by weight of the first solution, 20 to 30 parts by weight of hydroxyapatite, and 20 to 30 parts by weight of ethanol at 30 to 40°C for 1 to 2 hours. It's a process.

At this time, hydroxyapatite is a ceramic-based material with high bioactivity and can support quercetin to express its function in skin tissues, and hydroxyapatite itself is biodegradable and thus may be decomposed without remaining on the skin. In addition, ethanol may be removed in the above-described second drying step as a solvent for dispersing the first solution and hydroxyapatite.

Finally, in the step of obtaining the filtrate, the second solution is precipitated for 30 to 60 minutes, and then the filtered filtrate is obtained. Since the filtrate filtered here is an antioxidant, some of the ethanol in the second solution preparation step in the filtrate obtaining step may be removed.

Antioxidants prepared through such a process provide properties that can further reinforce the anti-inflammatory function of the adjuvant by removing active oxygen having free radicals around the area where the head office 10 is inserted.

As described so far, the configuration and operation of the twisted medical thread and its manufacturing method according to the present invention have been expressed in the above description and drawings, but these are only described as examples, and the spirit of the present invention is limited to the above description and drawings. Of course, various changes and changes are possible without departing from the technical spirit of the present invention.

10: Headquarters 11: Standing site
12: depression site 13: cog
100: chamber 200: fixing means
210: first fixing means 220: second fixing means
230: rotating part 240: shaft
S100: first step S110: second step
S120: third step S130: fourth step
S200: fibroin manufacturing step S210: primary material manufacturing step
S220: Secondary material manufacturing step S230: Supernatant removal step

Claims (11)

As a method of manufacturing a twisted medical thread,
A first step of fixing each end portion of the head office to first and second fixing means spaced apart by the length of the head office;
A second step of twisting the main office by rotating at least one of the first and second fixing means at 1 to 5 rotations;
A third step of drying the twisted head office at 30 to 40° C. for 30 minutes to 6 hours;
Including; a fourth step of sterilizing the dried head office
The third step,
A first drying step of drying the twisted head office at 30 to 40°C for 30 minutes to 3 hours, a spraying step of spraying an auxiliary agent including fibroin to the dried head office, and the auxiliary agent sprayed Including a second drying step of drying the head office for 30 minutes to 3 hours at 30 to 40 ℃,
The adjuvant,
Silk fiber 60 to 70 parts by weight, water 20 to 30 parts by weight, sodium carbonate (Na ₂ CO ₃ ) 10 to 20 parts by weight, mixed at 40 to 50°C for 1 to 3 hours, and then at 60 to 70°C for 5 to 7 hours Drying to prepare fibroin;
Preparing a primary material by mixing 30 to 40 parts by weight of fibroin, 30 to 40 parts by weight of water, and 30 to 40 parts by weight of polysorbate 80 at 20 to 30°C for 30 to 60 minutes;
After mixing 70 to 80 parts by weight of the primary substance and 20 to 30 parts by weight of sodium chloride, and dispersing for 1 to 5 minutes at 25,000 to 30,000 rpm in a homogenizer, a filtrate filtered through a filter of 5 to 20 μm was obtained. Preparing a tea material;
60 to 70 parts by weight of the secondary material, 20 to 30 parts by weight of an antioxidant material including hydroxyapatite and quercetin, and 10 to 20 parts by weight of ethanol are mixed, and then 5 to 10 minutes at 3000 to 4000 rpm During centrifugation and then removing the supernatant; characterized in that produced through, the manufacturing method of a medical thread. The method of claim 1,
The second step,
And rotating the first and second fixing means in different directions at different rotational speeds. The method of claim 1,
The fixing means,
It can be moved back and forth along the longitudinal direction of the headquarters,
The second step,
Rotating at least one of the first and second fixing means at a first rotation speed of 1 to 2 times,
And further rotating at least one of the first and second fixing means at a second rotation speed of 1 to 2 times while the fixing means is moved to the outside of the main office and the main office is pulled. A method of manufacturing a medical thread. The method of claim 1,
The fixing means,
It can be moved back and forth along the longitudinal direction of the headquarters,
The second step,
Rotating at least one of the first and second fixing means at a first rotation speed of 1 to 2 times,
Measuring the elastic limit of the pulled head office while moving the fixing means in an outer direction of the head office to pull the head office,
Restoring the main office by moving the fixing means in the inner direction of the main office, and
And further rotating at least one of the first and second fixing means at a second rotation speed of 1 to 2 times according to the height of the elastic limit of the head office. The method of claim 1,
The antioxidant substances,
Preparing a first solution by mixing 60 to 70 parts by weight of quercetin and 30 to 40 parts by weight of dimethyl sulfoxide at 20 to 30°C for 10 to 30 minutes;
Preparing a second solution by mixing 50 to 60 parts by weight of the first solution, 20 to 30 parts by weight of the hydroxyapatite, and 20 to 30 parts by weight of ethanol at 30 to 40°C for 1 to 2 hours;
Precipitating the second solution for 30 to 60 minutes, and then obtaining a filtered filtrate. delete delete delete delete delete delete

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