KR102112311B1 - Method and system for cognitive function test - Google Patents

Abstract

The present invention is a cognitive function test method comprising: (a) measuring an amplitude modulation threshold and a frequency modulation threshold that a subject can detect; (b) receiving an electroencephalogram of the subject measured according to a first stimulus sound provided by changing amplitude or frequency based on the amplitude modulation threshold and the frequency modulation threshold; (c) receiving a functional magnetic resonance image when a second stimulus is provided with a sound intensity determined based on the amplitude modulation threshold and the frequency modulation threshold, and the subject responds according to the provision of the second stimulus. ; And (d) analyzing the cognitive function of the subject based on the received EEG and functional magnetic resonance imaging of the subject.

Description

METHOD AND SYSTEM FOR COGNITIVE FUNCTION TEST}

The present invention relates to a popular function test technology, and relates to a cognitive function test method and system for testing cognitive function by measuring structural and functional changes in the brain using stimuli that are acoustically similar to everyday language.

Statistically, about 22% of Korea's population has hearing loss, and in elderly people over 65, about 30% are moderate-to-low-hearing patients who need hearing aids such as hearing aids. In modern society, hearing loss is gradually increasing due to excessive noise exposure and environmental factors such as the use of mobile phones, but the hearing loss rate is very low due to prejudice against hearing aids. It is often difficult to see. A cognitive disorder, such as dementia, along with senile deafness can be cited as a frequent medical problem among the elderly. Among them, mild cognitive impairment (MCI) is classified as an intermediate stage between normal aging and dementia because there is no cognitive function, especially memory loss, compared with the same age group, and there is no great difficulty in daily life before the stage of dementia development. . The prevalence of MCI is approximately 28%, estimated to be more than a quarter of the population aged 65 and over. About 10-15% of MCI patients develop dementia, especially Alzheimer's disease, and are classified as high-risk. MCI is an early stage of finding Alzheimer's disease, but it is also clinically important because it is known to have the best treatment effect.

With age, senile hearing loss occurs due to degeneration of peripheral auditory organs. When hearing loss is neglected, the deterioration of cognitive function is accelerated, and the likelihood of developing dementia increases. The incidence of dementia increases by 2 to 5 times in patients with hearing impairment, because in the case of hearing impairment, the central auditory nerve deteriorates due to inability to hear even when sound stimulation comes in, thereby deteriorating the overall cognitive function. However, since most of the previous studies that investigated the relationship between auditory ability and cognitive function change used behavioral measurement method, the reliability of the results was lowered because the subject's condition and the subject's subject were involved, and changes occurring in the central nervous system could be observed. It has its inherent limitations.

Korean Patent Publication No. 10-2018-0021017

An object of the present invention is to provide a cognitive function test method and system for testing cognitive function using electroencephalogram and functional magnetic resonance imaging to objectively measure the correlation between hearing and cognitive function.

A first aspect of the present invention for achieving the above object is a cognitive function test method comprising: (a) measuring an amplitude modulation threshold and a frequency modulation threshold that a subject can detect; (b) receiving an electroencephalogram of the subject measured according to a first stimulus sound provided by changing amplitude or frequency based on the amplitude modulation threshold and the frequency modulation threshold; (c) receiving a functional magnetic resonance image obtained by photographing a subject responding to the second stimulus sound provided with the sound intensity determined based on the amplitude modulation threshold and the frequency modulation threshold, and providing the second stimulus sound; And (d) analyzing the cognitive function of the subject based on the received EEG and functional magnetic resonance imaging of the subject.

Preferably, the step (a) comprises: providing a white noise whose speed of amplitude modulation is modulated to determine the amplitude modulation threshold; And determining a frequency modulation threshold by providing a frequency-modulated sound based on a specific frequency.

Preferably, the step (b) includes receiving an electroencephalogram signal from a plurality of electrodes attached to the scalp of the subject according to the provision of the first stimulation sound, wherein the plurality of electrodes attached to the scalp Each location information and the EEG signal received from the corresponding electrode may be associated.

Preferably, the step (d) may include analyzing the position and intensity activated in the cerebrum according to the stimulation of the first stimulation sound using the EEG signal and the location information of the electrode associated with the EEG signal. .

Preferably, the step (c) comprises the step of providing a specific ratio of noise inserted into the background of the second stimulus sound; Adjusting a sound intensity of the second stimulus sound or a ratio of noise to be inserted into the second stimulus sound according to a subject's response to the second stimulus sound; And it may include the step of providing a second stimulation sound is the ratio of the sound intensity or noise is adjusted.

Preferably, after the second stimulus sound is provided, a functional magnetic resonance image is taken, and after a certain time after the functional magnetic resonance image is taken, a second stimulus sound having a controlled rate of sound intensity or noise is provided. Can be.

Preferably, the step (d) may include analyzing the activity of the auditory cortex of both hemispheres according to the stimulation of the second stimulation sound, using the functional magnetic resonance imaging.

A second aspect of the present invention for achieving the above object, a threshold measurement unit for measuring the amplitude modulation frequency and frequency modulation threshold that can be detected by the subject; An electroencephalography test unit for receiving an electroencephalogram of the subject measured according to a first stimulus sound provided by changing amplitude or frequency based on the amplitude modulation threshold and the frequency modulation threshold; An image inspection unit receiving a functional magnetic resonance image when a second stimulus is provided with a sound intensity determined based on the amplitude modulation threshold and a frequency modulation threshold, and the subject responds according to the provision of the second stimulus; And a cognitive function analysis unit analyzing the cognitive function of the subject based on the received EEG and functional magnetic resonance imaging of the subject.

Preferably, the threshold measurement unit may determine the amplitude modulation threshold by providing a white noise whose speed of amplitude modulation is modulated, and determine the frequency modulation threshold by providing a sound modulated based on a specific frequency.

Preferably, the electroencephalography test unit receives an electroencephalogram signal from a plurality of electrodes attached to the scalp of the subject in accordance with the provision of the first stimulation sound, and the location information of each of the plurality of electrodes attached to the scalp and corresponding The EEG signal received at the electrode may be associated.

Preferably, the cognitive function analysis unit may analyze the location and intensity activated in the cerebrum according to the stimulation of the first stimulation sound by using the EEG signal and the location information of the electrode associated with the EEG signal.

Preferably, the image inspection unit provides a specific ratio of noise by inserting a noise into the background of the second stimulus sound, and according to the subject's response to the second stimulus sound, the sound intensity of the second stimulus sound or the second The method may include adjusting a ratio of noise to be inserted into the stimulus sound, and providing a second stimulus sound with the sound intensity or noise ratio adjusted.

Preferably, after the second stimulus sound is provided, a functional magnetic resonance image is taken, and after a certain time after the functional magnetic resonance image is taken, a second stimulus sound having a controlled rate of sound intensity or noise is provided. Can be.

Preferably, the cognitive function analyzer may analyze the activity of the auditory cortex of both hemispheres according to the stimulus of the second stimulus sound using the functional magnetic resonance image.

As described above, according to the present invention, the correlation between cognitive ability and hearing can be understood at the level of the cerebral cortex, and scientific understanding of the central auditory system can be improved by measuring cerebral plasticity through a hearing aid. Since it is closely related to areas related to social communication such as language, cognition, and emotion, it has the effect of helping to understand the overall connectivity and plasticity of the central nervous system.

1 is a block diagram of a cognitive function test system according to a preferred embodiment of the present invention.
2 is a block diagram of a cognitive function test system according to an embodiment.
3 is a flowchart of a method for testing a cognitive function according to an embodiment.
4 is an exemplary diagram for explaining a method of measuring an amplitude modulation threshold and a frequency modulation threshold.
5 is an exemplary view showing a user interface for receiving a response of a subject according to a second stimulus sound.
6 is an exemplary view for explaining a method of photographing a functional magnetic resonance image.
7 is an exemplary view for explaining an analysis result of an electroencephalogram according to a first stimulus sound.
8 is an exemplary view for explaining the analysis results of the functional magnetic resonance image according to the second stimulus sound.
9 is an exemplary view for explaining the results of analysis of EEG and functional magnetic resonance imaging.

Hereinafter, advantages and features of the present invention, and a method of achieving them will be clarified with reference to embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in various different forms, and only the embodiments allow the disclosure of the present invention to be complete, and the ordinary knowledge in the technical field to which the present invention pertains. It is provided to fully inform the holder of the scope of the invention, and the invention is only defined by the scope of the claims. The same reference numerals refer to the same components throughout the specification. “And/or” includes each and every combination of one or more of the items mentioned.

Although the first, second, etc. are used to describe various elements, components and/or sections, it goes without saying that these elements, components and/or sections are not limited by these terms. These terms are only used to distinguish one element, component or section from another element, component or section. Therefore, it goes without saying that the first element, first component or first section mentioned below may be a second element, second component or second section within the technical spirit of the present invention.

In addition, in each step, an identification code (for example, a, b, c, etc.) is used for convenience of description, and the identification code does not describe the order of each step, and each step is clearly specified in context. Unless the order is specified, it may occur differently from the order specified. That is, each step may occur in the same order as specified, may be performed substantially simultaneously, or may be performed in the reverse order.

The terminology used herein is for describing the embodiments and is not intended to limit the present invention. In the present specification, the singular form also includes the plural form unless otherwise specified in the phrase. As used herein, ““comprises” and/or ““comprising” refers to one or more of the other components, steps, operations and/or elements mentioned. Does not exclude the presence or addition of

Unless otherwise defined, all terms (including technical and scientific terms) used in the present specification may be used as meanings commonly understood by those skilled in the art to which the present invention pertains. In addition, terms defined in the commonly used dictionary are not ideally or excessively interpreted unless specifically defined.

In addition, in describing embodiments of the present invention, when it is determined that a detailed description of known functions or configurations may unnecessarily obscure the subject matter of the present invention, the detailed description will be omitted. In addition, terms to be described later are terms defined in consideration of functions in an embodiment of the present invention, which may vary according to a user's or operator's intention or practice. Therefore, the definition should be made based on the contents throughout this specification.

1 is a block diagram of a cognitive function test system according to a preferred embodiment of the present invention.

Referring to FIG. 1, the system according to the present invention includes an electrode 110, an imaging device 120, and a cognitive function test system 130.

The electrode 110 is a device that is attached to the scalp of the subject and measures the flow of electricity generated according to signal transmission between the brain nerves. Preferably, a plurality of electrodes 110 may be included, for example, 64 electrodes may be attached to a specific location of the subject's scalp, and through this, accuracy and analysis range of data received from the electrodes 110 may be determined. Can be extended. Here, the position information of each electrode 110 attached to the scalp of the subject can be digitized and stored in advance.

The imaging device 120 is a device that photographs functional magnetic resonance imaging (fMRI), which measures the difference in oxygen concentration in the blood that occurs as nerve cells are activated by the subject's mental activity by changing the magnetic field. Device. When the imaging device 120 is used, it is possible to extract brain signals related to brain functions and track the location of the brain functions.

The cognitive function test system 130 is connected to the electrode 110 and the imaging device 120 to analyze the cognitive function of the subject based on data received from the electrode 110 and the imaging device 120. Preferably, the cognitive function inspection system 130 may be implemented as a single server or a system including each configuration described with reference to FIG. 2 as a separate device or module.

2 is a block diagram of a cognitive function test system according to an embodiment.

2, the cognitive function test system 130 includes a threshold measurement unit 131, an electroencephalography test unit 132, an image inspection unit 133, a cognitive function analysis unit 134, and a control unit 135, The control unit 135 controls the operation and data flow of the threshold measurement unit 131, the EEG test unit 132, the image test unit 133, and the cognitive function analysis unit 134. In addition, the cognitive function test system 130 Although not shown in the drawings, a user interface may be included to support the performance of the cognitive function test, and the user interface may be integrally provided with the cognitive function test system 130 or separately provided to be connected wirelessly or wiredly. Can be.

Hereinafter, a cognitive function test method performed in each configuration of the cognitive function test system 130 will be described in more detail with reference to FIG. 3.

The threshold measurement unit 131 measures an amplitude modulation threshold and a frequency modulation threshold that can be detected by the subject (step S310). That is, the threshold measurement unit 131 is to measure the weakest amplitude and frequency that the subject can detect.

Preferably, the threshold measurement unit 131 may determine the amplitude modulation threshold by providing a white noise in which the speed of amplitude modulation is modulated. More specifically, the threshold measurement unit 131 may provide the modulated sound in various ways to determine the amplitude modulation threshold, 3-interval, 3-alternative, forced-choice, 2-down and 1-up procedure It can be provided in the same way. Here, all of the methods provide a total of three types of sounds, including one sound with modulation and two sounds without modulation, and the subject who heard the sound selected the sound with modulation among the three sounds. This is how you choose. Referring to (a) of FIG. 4, a screen provided to a subject during an inspection by the threshold measurement unit 133 through a user interface of the cognitive function test system 130, and the subject hears three sounds and then One can be selected through the 1, 2, and 3 buttons displayed on the screen. The user interface illustrated in FIG. 4A is only an example and can be implemented in various ways. The forced-choice is a method in which the subject must select one of the three sounds, and if the subject's selection is correct, it provides a more difficult distinction between the sound with modulation and the sound without modulation, and if the subject's selection is wrong It is easier to provide a distinction between a sound with modulation and a sound without modulation. For example, an amplitude modulated stimulus sound may be provided for 1 second as shown in FIG. 4(b) using a rate of 4 levels of amplitude modulation corresponding to 4 Hz, 40 Hz, 100 Hz, and 300 Hz. That is, the threshold measurement unit 131 outputs the stimulus sound while lowering the amplitude modulation depth from 100% to 0% at a specific frequency to determine the amplitude modulation threshold, and outputs the subject according to the output stimulus sound. The amplitude modulation threshold value corresponding to the lowest amplitude modulation depth that can be detected by the subject is determined according to the response, that is, whether the subject detects the modulation.

Preferably, the threshold measurement unit 131 may determine a frequency modulation threshold by providing a sound modulated with a frequency based on a specific frequency. Preferably, the threshold measurement unit 131 may use a tone burst of two fundamental frequencies to determine the frequency modulation threshold, for example, a basic tone corresponding to 250 Hz and 4000 Hz. The threshold measurement unit 131 provides frequency-modulated stimulation sound for each fundamental frequency by modulating the frequency by 10% (275 Hz), 50% modulation (375 Hz), or 100% modulation (500 Hz) for 250 Hz, In the case of 4000 Hz, 5% modulation (4200 Hz), 15% modulation (4600 Hz), or 30% modulation (5200 Hz) may be used to provide a frequency modulated stimulus sound. Here, as shown in (c) of FIG. 4, the frequency modulated stimulus sound may be output for 400 ms while the continuous tone is output, and the distance between the frequency modulated stimulus sounds may be set to 2.2 seconds.

The EEG test unit 132 receives the EEG of the subject measured according to the first stimulus sound provided by changing the amplitude or frequency based on the amplitude modulation threshold and the frequency modulation threshold (step S320). Preferably, the EEG test unit 132 may receive the EEG signal from the plurality of electrodes 110 attached to the subject's scalp according to the provision of the first stimulation sound. Here, the location information of each of the plurality of electrodes 110 attached to the scalp and the EEG signal received from the corresponding electrode may be stored in association with each other.

The image inspection unit 133 receives a functional magnetic resonance image photographing the subject responding to the second stimulus sound provided with the sound intensity determined based on the amplitude modulation threshold and the frequency modulation threshold, and providing the second stimulus sound ( Step S330). Here, the sound intensity is determined as the most comfortable level of each subject, and the optimum sound intensity is presented to the subject after the reference sound intensity (for example, 65 dB), and then the sound intensity of the reference sound intensity is given to the subject. It is displayed as one of 1 (very small to be inaudible) to 10 (very large to be painful), and the sound intensity is changed based on the standard sound intensity to correspond to 7 (sound is loud but comfortable). You can determine the optimum sound intensity by finding the intensity.

Preferably, the image inspection unit 133 inserts a specific ratio of noise into the background of the second stimulus sound, and is inserted into the sound intensity of the second stimulus sound or the second stimulus sound according to the subject's response to the second stimulus sound. After adjusting the ratio of noise, it is possible to provide a second stimulus sound in which the ratio of sound intensity or noise is adjusted. Here, the second stimulus sound is provided, the second stimulus sound is adjusted based on the response of the received subject according to the second stimulus sound, the second stimulus sound is adjusted, and the second stimulus sound is adjusted. Accordingly, the process of re-adjusting and providing the second stimulus sound based on the received response of the subject may be repeated a predetermined number of times or more.

For example, the second stimulation sound may be used by recording three numbers out of nine numbers from 1 to 9 randomly and continuously, and the subject hears the second stimulation sound and the second stimulation sound Three numbers corresponding to or may be input to the image inspection unit 133 through a user interface in a different way. Referring to FIG. 5, a screen provided to a subject during an inspection by the image inspection unit 133 through a user interface of the cognitive function inspection system 130, and when the subject hears and speaks the second stimulus sound, the image inspection unit 133 By recognizing the subject's voice, the three numbers spoken by the subject can be displayed on the screen, and the subject selects SUBMIT when the three numbers displayed on the screen match the number he or she spoke, and deletes them if they do not match ( CLEAR). Alternatively, the subject may directly input three numbers corresponding to the second stimulus sound using the number buttons displayed on the screen. The user interface illustrated in FIG. 5 is only an example and can be implemented in various ways. As described above, according to the number input by the subject, the image inspection unit 133 lowers the sound intensity of the second stimulus sound by 2 dB while maintaining the ratio of noise when the information input by the subject matches the second stimulus sound, If the information input by the subject does not match the second stimulus, the second stimulus with the sound intensity or noise ratio adjusted after increasing the sound intensity of the second stimulus by 2 dB while maintaining the ratio of the noise Can provide. In addition, the signal to noise ratio (SNR) to be inserted into the background of the second stimulus sound can be adjusted from -20dB to 0dB, and the image inspection unit 133 displays information input by the subject with the second stimulus sound. In the case of a match, the ratio of noise is lowered to make the inspection more difficult, and if the information input by the subject does not match the second stimulus, the ratio of the noise can be increased to make the inspection easier. Although the ratio and the sound intensity of the noise are respectively adjusted according to the information input by the examinee, the ratio and the noise intensity of the noise may be simultaneously adjusted according to the condition of the examinee and the purpose of the examination, and the range of the regulation may vary. It is deformable.

Preferably, the functional magnetic resonance image is photographed by the imaging device 120 after the second stimulus sound is provided, and the second stimulus in which the ratio of sound intensity or noise is adjusted after a certain time after the functional magnetic resonance image is photographed Sound can be provided. The noise generated from the gradient coil of the imaging device 120 for recording the functional magnetic resonance image may affect the auditory stimulation test result by the second stimulus sound. Therefore, in order to minimize the effect of the noise of the imaging device 120, in the present invention, by adjusting the image repetition time (TR) as shown in FIG. 6, the functional magnetic resonance image is driven to be taken within a certain period of time. will be. For example, referring to FIG. 7, in an image period corresponding to 3 seconds, a second magnetic stimulation image is taken from the imaging device 120 by emitting a pulse for 2 seconds, and then a second stimulus after 1 second The functional magnetic resonance image is photographed in a manner that provides sound, so that the influence of the noise of the imaging device 120 is not reflected in the reaction of the subject according to the second stimulus sound.

The cognitive function analysis unit 134 analyzes the cognitive function of the subject based on the received EEG and functional magnetic resonance imaging of the subject (step S340).

Preferably, the cognitive function analysis unit 134 may analyze the location and intensity activated in the cerebrum according to the stimulation of the first stimulation sound using the EEG signal and the location information of the electrode associated with the EEG signal. More specifically, the cognitive function analysis unit 134 may perform a distributed source analysis using a dipole to analyze the direction of the dipole, and thus identify the location of cerebral activity. In addition, the cognitive function analysis unit 134 analyzes changes in neural oscillation by measuring signals such as Delta, Theta, Alpha, Beta, and Gamma by performing time-frequency analysis. Can be.

For example, referring to FIG. 7, as an analysis result according to the stimulus of the first stimulus sound, when the first stimulus sound provided by changing the amplitude is provided, the N1 wave change of the subject received from the electrode 110 , N1 wave topography, and N1 wave source. Referring to FIG. 7, it can be seen that as the speed of the amplitude increases, the amplitude of the N1 wave decreases and the N1 wave's negative decreases in the N1 wave topography, and the position of cerebral activation from the source analysis result of the N1 wave It can be seen that there is a pattern of movement from the auditory cortex toward the frontal lobe. The cognitive function analyzer 134 may measure temporal processing and frequency processing using the N1 response, and preferably, modulate the amplitude of the stimulus sound. By measuring the change of the N1 wave response according to, the time processing capability corresponding to the processing capability of temporal information in the cerebrum can be evaluated, and the frequency processing capability can be evaluated by measuring the change of the N1 wave response according to the frequency modulation of the stimulus sound. have.

Preferably, the cognitive function analysis unit 134 may analyze the activity of the auditory cortex of both hemispheres according to the stimulation of the second stimulation sound using the functional magnetic resonance image. For example, the cognitive function analysis unit 134 may confirm activation of both auditory cortex based on the functional magnetic resonance image as illustrated in FIG. 8.

Preferably, the cognitive function analysis unit 134 analyzes whether the activity of the cerebrum analyzed based on the EEG occurs in the location of the brain obtained from the functional magnetic resonance image using the EEG and the functional magnetic resonance image of the subject. Can be. For example, the cognitive function analysis unit 134 may perform analysis through the BESA MRI program, and more specifically, the cognitive function analysis unit 134 inputs a functional magnetic resonance image into the BESA MRI program and analyzes the BESA EEG. By applying a visual functional magnetic resonance image, as shown in FIG. 9, it is possible to analyze where the brain activity of the subject occurs in the brain.

In one embodiment, information on the cognitive function of the subject obtained through the cognitive function analysis unit 134 is used for correlation analysis of the degree of cognitive decline (percentile in cognitive psychological tests) according to the degree of hearing loss (dB). Can be used. Here, a statistical simple correlation analysis (Pearson Correlation Coefficient) between the hearing loss level and the score of the cognitive function test may be used as the correlation analysis.

On the other hand, the cognitive function test method according to an embodiment of the present invention may also be embodied as computer readable codes on a computer readable recording medium. The computer-readable recording medium includes all types of recording devices in which data readable by a computer system is stored.

For example, the computer-readable recording medium includes ROM, RAM, CD-ROM, magnetic tape, hard disk, floppy disk, removable storage device, and non-volatile memory (Flash Memory). , Optical data storage, and the like.

In addition, the computer-readable recording medium may be distributed over computer systems connected by a computer communication network, and stored and executed as code readable in a distributed manner.

Although the preferred embodiments of the cognitive function test method and system according to the present invention described above have been described, the present invention is not limited thereto, and is implemented by various modifications within the scope of the claims and detailed description of the invention and the accompanying drawings. It is possible and this also belongs to the present invention.

110: electrode
120: imaging device
130: cognitive function test system
131: threshold measurement unit
132: EEG test
133: image inspection unit
134: cognitive function analysis unit
135: control unit

Claims (15)

As a method of testing cognitive intelligence using a threshold measurement unit, an electroencephalography test unit, an imaging test unit, and a cognitive function analysis unit
(a) measuring an amplitude modulation threshold and a frequency modulation threshold that the threshold measurement unit can detect by the subject;
(b) receiving the EEG measured by the EEG test unit according to the first stimulus sound provided by changing the amplitude or frequency based on the amplitude modulation threshold and the frequency modulation threshold;
(c) A functional magnetic resonance image obtained by the image inspection unit photographing a subject responding according to the provision of the second stimulus sound, and a second stimulus sound provided with a sound intensity determined based on the amplitude modulation threshold and the frequency modulation threshold. Receiving; And
(d) the cognitive function analysis unit includes analyzing the cognitive function of the subject based on the received EEG and functional magnetic resonance imaging of the subject,
Step (a) is,
Determining the amplitude modulation threshold by providing a white noise whose speed of amplitude modulation is modulated; And
And determining a frequency modulation threshold by providing a sound modulated based on a specific frequency.
delete The method of claim 1, wherein the step (b),
Receiving an electroencephalogram signal from a plurality of electrodes attached to the scalp of the subject in accordance with the provision of the first stimulation sound,
Cognitive function test method characterized in that the location information of each of the plurality of electrodes attached to the scalp and the EEG signal received from the electrode are associated.
According to claim 3, step (d) is,
And analyzing the location and intensity activated in the cerebrum according to the stimulation of the first stimulation sound, using the location information of the electrode associated with the EEG signal and the EEG signal.
The method of claim 1, wherein step (c),
A step in which a specific ratio of noise is inserted and provided in the background of the second stimulus sound;
Adjusting a sound intensity of the second stimulus sound or a ratio of noise to be inserted into the second stimulus sound according to a subject's response to the second stimulus sound; And
And providing a second stimulus sound in which the sound intensity or noise ratio is adjusted.
The method of claim 5,
After the second stimulus sound is provided, a functional magnetic resonance image is taken, and after a certain time after the functional magnetic resonance image is taken, a second stimulus sound having a controlled sound intensity or noise ratio is provided. Cognitive function test method.
The method of claim 6, wherein the step (d),
And analyzing the activity of the auditory cortex of both hemispheres according to the stimulation of the second stimulus sound using the functional magnetic resonance imaging.
A threshold measurement unit for measuring an amplitude modulation threshold and a frequency modulation threshold that can be detected by a subject;
An electroencephalography test unit for receiving an electroencephalogram of the subject measured according to a first stimulus sound provided by changing amplitude or frequency based on the amplitude modulation threshold and the frequency modulation threshold;
An image inspection unit receiving a functional magnetic resonance image when a second stimulus is provided with a sound intensity determined based on the amplitude modulation threshold and the frequency modulation threshold, and the subject responds according to the provision of the second stimulus; And
A cognitive function analysis unit for analyzing the cognitive function of the subject based on the received EEG and functional magnetic resonance imaging of the subject,
The threshold measurement unit,
A cognitive function test system characterized by determining the amplitude modulation threshold by providing a white noise whose speed of amplitude modulation is modulated, and determining the frequency modulation threshold by providing a sound modulated based on a specific frequency.
delete According to claim 8, The electroencephalography test unit,
According to the provision of the first stimulation sound, the EEG signal is received from a plurality of electrodes attached to the scalp of the subject, but the location information of each of the plurality of electrodes attached to the scalp and the EEG signal received from the electrode are related. Cognitive function inspection system, characterized in that.
11. The method of claim 10, The cognitive function analysis unit,
A cognitive function test system characterized by analyzing the location and intensity activated in the cerebrum according to the stimulation of the first stimulation sound, using the location information of the electrodes associated with the EEG signal and the EEG signal.
According to claim 8, The image inspection unit,
Provided by inserting a specific ratio of noise in the background of the second stimulus sound, and the sound intensity of the second stimulus sound or the ratio of noise to be inserted into the second stimulus sound according to the subject's response to the second stimulus And providing a second stimulus sound in which the sound intensity or the ratio of noise is adjusted.
The method of claim 12,
After the second stimulus sound is provided, a functional magnetic resonance image is taken, and after a certain time after the functional magnetic resonance image is taken, a second stimulus sound having a controlled sound intensity or noise ratio is provided. Cognitive function testing system.
The method of claim 13, wherein the cognitive function analysis unit,
A cognitive function test system characterized by analyzing the activity of the auditory cortex of both hemispheres according to the stimulation of the second stimulus sound using the functional magnetic resonance imaging.
A computer-readable recording medium in which a program capable of executing the method of any one of claims 1, 3 to 7, is recorded on a computer.

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