KR102089712B1 - Wound Dressing Comprising Non-Woven Fabric Sheet With Microscopic Pores for Blood Coagulation and Method of Manufacturing the Same - Google Patents

Abstract

One embodiment of the present invention provides a wound coating material having a non-woven fabric sheet having fine pores for blood clotting and a method for manufacturing the same. The nonwoven sheet includes a first cover layer and a second cover layer. The first cover layer is arranged to face the wound surface, and the second cover layer is arranged to face the wound surface. The second cover layer is combined with the first cover layer to form a receiving space in which blood of the human body is accommodated. The first cover layer or the second cover layer includes a plurality of fine holes. The plurality of micropores has an average diameter equal to or greater than the average diameter of the platelets and is larger than the platelets so that the platelets of the components contained in the blood of the human body in the receiving space pass through and the components having a size larger than the platelets do not pass through. It has an average diameter that is smaller than the size component.

Description

Wound Dressing Comprising Non-Woven Fabric Sheet With Microscopic Pores for Blood Coagulation and Method of Manufacturing the Same}

The present invention relates to a wound coating material and a method for manufacturing the same, and more particularly, to a wound coating material having a non-woven fabric sheet having fine pores for blood clotting and a method for manufacturing the same.

In a sudden bleeding wound caused by trauma or the like, absorption of blood leaking from the wound surface, prevention of bacterial penetration into the wound surface, and hemostatic action are important.

Wound covering materials are used for blood absorption, prevention of bacterial invasion, and hemostatic action by treating bleeding wounds caused by such trauma.

For example, the Korean Patent Office Publication No. 10-2007-0118730 discloses a wound coating material having excellent biocompatibility, biodegradability, anti-bacterial penetration, breathability, and moisture retention. In addition, the Korean Patent Office Publication No. 10-2018-0030494 discloses a dressing hemostatic pad having excellent exudate absorbency and improving hemostasis by compressing the wound.

On the other hand, in the bleeding wound due to trauma, it is known that the natural healing process through the blood clotting mechanism involving blood platelets, as well as blood absorption and prevention of bacterial infiltration and hemostasis by pressure are important. That is, a natural healing process in which regeneration of damaged tissues is promoted by platelet or blood cell leaking from damaged tissues of the wound surface reacts with damaged tissues of the wound surface, thereby activating a blood clotting mechanism.

Conventional wound covering materials allow blood components, including platelets, to be absorbed into the covering material without staying on the wound surface, so blood cloagation and blood clot / crust through a blood clotting mechanism involving platelets seen in the natural healing process / scab). Platelets or blood cells leaked from the damaged tissue of the wound surface react with the damaged tissue of the wound surface to generate a blood clotting mechanism, because not only the blood cells leaking from the wound surface but also the platelets do not stay on the wound surface and are absorbed by the wound covering material. to be.

Accordingly, the platelets contained in the blood leaking from the wound surface are prevented from falling off from the wound surface and stayed on the wound surface, as well as additionally supplying platelets to the wound surface, which significantly induces blood clotting mechanisms, resulting in natural hemostasis and What is needed is a wound covering that can greatly accelerate the healing process.

Republic of Korea Patent Office Publication No. 10-2007-0118730 Patent Publication Korean Patent Office Publication No. 10-2018-0030494 Patent Publication

One problem to be solved by the present invention is to prevent the platelets contained in the blood leaking from the wound surface from falling off the wound surface and to stay on the wound surface, as well as the blood clotting mechanism by additionally supplying platelets to the wound surface It is to provide a wound coating material having a non-woven fabric sheet having fine pores for coagulation of blood that can significantly promote natural hemostasis and healing processes by significantly inducing and a method for manufacturing the same.

The problems to be solved by the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

A wound coating material having a non-woven fabric sheet having fine pores for blood clotting according to an embodiment of the present invention includes a non-woven fabric sheet including a first cover layer and a second cover layer. The first cover layer is arranged to face the wound surface, and the second cover layer is arranged to face the wound surface. The second cover layer is combined with the first cover layer to form a receiving space in which blood of the human body is accommodated. The first cover layer or the second cover layer includes a plurality of fine holes. The plurality of micropores has an average diameter equal to or greater than the average diameter of the platelets and is larger than the platelets so that the components contained in the blood of the human body in the receiving space pass through the platelets and do not pass through the components larger than the platelets. It has an average diameter that is smaller than the size component.

When the wound coating material having such a configuration is arranged and pressed on the wound surface, platelets are supplied to the wound surface through a plurality of micropores among the components contained in the human blood in the receiving space, and the components contained in the blood of the human body in the receiving space Among them, a component having a size larger than a platelet does not pass through a plurality of micro-pores and is not supplied to the wound surface, so the concentration of the platelet increases on the wound surface.

In addition, among the components contained in the blood of the human body in the receiving space, while platelets are supplied to the wound surface through the plurality of fine holes, platelets contained in the blood leaking from the wound surface cannot flow into the receiving space through the plurality of fine holes. You will stay on the wound.

Therefore, the wound covering material having such a configuration prevents the platelets contained in the blood leaking from the wound surface from falling off the wound surface and stays on the wound surface, as well as significantly supplying platelets to the wound surface, thereby significantly improving the blood clotting mechanism. Induce it to greatly accelerate the natural hemostasis and healing process.

Here, the plurality of fine holes may be formed in the first cover layer. As a result, platelets contained in the blood of the human body in the receiving space can be directly supplied to the wound surface through a plurality of fine holes of the first cover layer arranged on the wound surface side, so that most of the platelets contained in the blood of the human body in the receiving space In the process of supplying to the wound surface, it is possible to supply without losing.

Here, the plurality of fine holes may be formed in the first cover layer and the second cover layer. This makes it possible to conveniently and quickly arrange the wound covering material on the wound surface so that any layer faces the wound surface without distinguishing the first cover layer and the second cover layer, so that it can quickly respond to the first aid of the wound surface. do.

Here, the average diameter of the plurality of fine holes may be 3.0 μm or more and 5.0 μm or less. Platelets having a diameter of about 2.0 μm or more and 3.0 μm or less pass through the plurality of micropores having an average diameter, and red blood cells having a diameter of 7.0 μm or more and 8.0 μm or less and leukocytes having a diameter of 12.0 μm or more do not pass through.

Here, the first cover layer or the second cover layer may be formed with an inlet hole through which blood of the human body flows into the accommodation space. Since blood of the human body can be injected into the receiving space through the inlet hole, blood is not injected into the receiving space when the wound covering is not used, but blood is injected into the receiving space only when the wound covering is used.

Here, the injection hole through which the autologous human blood is injected may penetrate the inlet hole. Therefore, since the blood extracted from the patient's own human body can be injected into the receiving space through the inlet hole using the injection needle, the first aid of the wound surface of the patient can be quickly performed in the field.

Here, it is arranged to cover the non-woven sheet while facing the wound surface, the pressing member to press the non-woven sheet to reach the wound surface through a plurality of micro-holes among the components contained in the blood of the human body in the receiving space It may further include. Thereby, by easily pressing the nonwoven sheet using the pressing member, the platelets contained in the blood of the human body in the receiving space can be easily guided to the wound surface, and in the process of pressing the nonwoven sheet to the blood of the human body in the receiving space. It prevents the contained plasma components from leaking to the outside and prevents bacterial penetration into the wound surface in the process of pressing the nonwoven sheet.

Here, the pressing member may include a plastic film material. The pressing member comprising such a material can more effectively achieve platelet guidance to the wound surface during the pressing process, prevention of external leakage of plasma components, and prevention of bacterial penetration into the wound surface.

Here, the first cover layer or the second cover layer is polyethylene (poly ethylene), polypropylene (poly prophylene), polyurethane (poly urethane), Teflon (teflon), silicone (silicone), PLA (poly lactic acid) )), PLA (poly L-form lactic acid), PCL (polycarprolactone (PCL)), PGA (poly glycolic acid), PLA (pol lactic glycolic acid) (PLGA), methyl Cellulose (methyl cellulose), hyaluronic acid, collagen, gelatin, lysine, alginate, elastine, fibronectine, cellulose, Rayon (rayon) and natural pulp (natural pulp) may include at least one selected from the group consisting of.

According to another embodiment of the present invention, a method of manufacturing a wound coating material having a non-woven fabric sheet having fine pores for blood clotting includes preparing a first cover layer arranged to face the wound surface, and opposite the wound surface. And preparing a second cover layer arranged to face the first cover layer and combining the first cover layer and the second cover layer to form a receiving space in which blood of the human body is accommodated. The first cover layer or the second cover layer includes a plurality of fine holes. The plurality of micropores has an average diameter equal to or greater than the average diameter of the platelets and is larger than the platelets so that the components contained in the blood of the human body in the receiving space pass through the platelets and do not pass through the components larger than the platelets. It has an average diameter that is smaller than the size component.

When the wound covering material produced by this method is arranged and pressed on the wound surface, platelets among the components included in the blood of the human body in the receiving space are supplied to the wound surface through a plurality of micropores, and are supplied to the blood of the human body in the receiving space. Among the components included, a component having a size larger than the platelet does not pass through a plurality of micropores and is not supplied to the wound surface, so the concentration of the platelet is increased on the wound surface.

In addition, among the components contained in the blood of the human body in the receiving space, while platelets are supplied to the wound surface through the plurality of fine holes, platelets contained in the blood leaking from the wound surface cannot flow into the receiving space through the plurality of fine holes. You will stay on the wound.

Therefore, the wound covering material produced by this method prevents the platelets contained in the blood leaking from the wound surface from falling off the wound surface and stays on the wound surface, as well as blood clotting by additionally supplying platelets to the wound surface. It significantly induces the mechanism, which can greatly accelerate the natural hemostasis and healing process.

Here, the first cover layer or the second cover layer may be formed with an inlet hole through which blood of the human body flows into the accommodation space. Since blood of the human body can be injected into the receiving space through the inlet hole, blood is not injected into the receiving space when the wound covering is not used, but blood is injected into the receiving space only when the wound covering is used.

One effect of the present invention is to prevent the platelets contained in the blood leaking from the wound surface from falling off the wound surface and to stay on the wound surface, as well as supplying platelets to the wound surface to significantly increase the blood clotting mechanism It is to provide a wound coating material having a non-woven fabric sheet having fine pores for coagulation of blood and a method for manufacturing the same, which can significantly accelerate the natural hemostasis and healing process by induction.

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

1 is a cross-sectional view schematically showing a blood clotting process in the wound surface.
2 is a plan view schematically showing a plane of a wound coating material having a non-woven fabric sheet having fine pores for blood clotting according to one embodiment of the present invention.
3 is a cross-sectional view schematically showing a section III-III of FIG. 2.
4 is a partially enlarged cross-sectional view showing an enlarged portion A of FIG. 3.
5 is a view showing that blood is injected into the human body in the receiving space of the wound coating of Figure 2;
6 is a cross-sectional view schematically showing a cross-section of a wound coating material having a non-woven fabric sheet having fine pores for blood clotting according to another embodiment of the present invention.
7 is a flowchart illustrating a method of manufacturing a wound coating material having a non-woven fabric sheet having fine pores for blood clotting according to another embodiment of the present invention.

The specific content for carrying out the invention will be described based on examples. These examples are provided as examples to enable those of ordinary skill in the art to understand the specific contents for carrying out the invention, and can be modified in various other forms, so the scope of the present invention It is not limited by the following examples.

In our body, when the wound is bleeding, hemostasis is caused by various mechanisms. The three factors that play the most important role in hemostasis are blood vessels, platelets, and blood clotting factors.

Blood clotting process, as shown in Figure 1, if the body is wounded and bleeding occurs, first, the blood vessels are contracted to reduce the amount of blood bleeding. Thereafter, the platelets adhere to the damaged vascular endothelial cells and aggregate with each other to form the initial primary thrombosis. Subsequently, coagulation factors in the blood are activated in turn, and the resulting fibrin is added to the primary hemostasis, creating a more stiff secondary hemostasis to stop bleeding completely.

The present invention aggregates platelets, which are one of the factors that play an important role in the above-described haemostasis mechanism, that is, the blood clotting mechanism, to the wound surface where bleeding occurs after wounding, so that platelets easily adhere to damaged vascular endothelial cells and easily cross each other It relates to a wound coating material and a method of manufacturing the same to make the initial primary hemostatic smoothly by agglomeration.

In the present invention, two mechanisms are applied to aggregate platelets on the wound surface to increase the concentration of platelets on the wound surface. That is, the present invention prevents the platelets contained in the blood leaking from the wound surface from falling off the wound surface and stays in the wound surface, as well as additionally supplying platelets to the wound surface, thereby concentrating platelet concentration in the wound surface. Will increase. Therefore, the platelets are easily and efficiently adhered to the damaged vascular endothelial cells and agglomerated with each other, so that the initial primary hemostasis is smoothly performed, and the fibrin produced by the large activation of coagulation factors in the blood is easily and efficiently It can be added.

(Example 1)

As shown in FIG. 2 by way of example, this embodiment is a wound coating material 100.

The wound covering material 100 covers the damaged area so that the damaged area is protected from the outside and can be quickly and effectively healed when the skin is damaged.

The wound covering material 100 includes a nonwoven fabric sheet 110 including a first cover layer 111 and a second cover layer 112.

The first cover layer 111 is a layer arranged to face the wound surface 10.

The second cover layer 112 is a layer arranged to face the wound surface 10 on the opposite side. The second cover layer 112 is combined with the first cover layer 111 to form a receiving space 113 in which blood of the human body is accommodated.

The first cover layer 111 and the second cover layer 112 may be combined by various methods. For example, the first cover layer 111 and the second cover layer 112 may be bonded by an adhesive. However, the present invention is not limited thereto, and the first cover layer 111 and the first cover layer 112 may be combined by various methods capable of forming an accommodation space 113 in which human blood can be accommodated.

The first cover layer 111 or the second cover layer 112 is polyethylene (poly ethylene), polypropylene (poly prophylene), polyurethane (poly urethane), Teflon (teflon), silicone (silicone), PLA (PLA) (poly lactic acid)), PLA (poly L-form lactic acid), PCL (polycarprolactone (PCL)), PGA (poly glycolic acid), PGA (pol lactic glycolic acid) )), Methyl cellulose, hyaluronic acid, collagen, gelatin, lysine, alginate, elastine, fibronectine, cellulose (cellulose), rayon (rayon) and natural pulp (natural pulp) may include at least one selected from the group consisting of.

The first cover layer 111 or the second cover layer 112 includes a plurality of fine holes 114. The plurality of micro-pores 114, the components contained in the blood of the human body of the receiving space 113 to pass through the platelets and components of a size larger than the platelets do not pass, the average of the same or greater than the average diameter of the platelets It has a diameter and an average diameter that is smaller than a component of a size larger than platelets.

Here, the average diameter of the plurality of fine holes 114, on the other hand, the plurality of fine holes 114 formed in the first cover layer 111 or the second cover layer 112 of one nonwoven sheet 110 When the micropores of various shapes having the same are converted into circular micropores each having the same size, it may mean the average diameter of the micropores of the circular shape. Therefore, the plurality of micro-holes 114 may include ones smaller than the average diameter of the platelets or may be larger than components of a size larger than the platelets contained in human blood, but the plurality of micro-pores 114 as a whole The average diameter of can be equal to or greater than the average diameter of platelets and smaller than the average diameter of components of a size larger than platelets.

On the other hand, the plurality of micro-holes 114 is formed to have a size through which the platelets contained in the blood of the human body in the receiving space 113 penetrate the first cover layer 111 or the second cover layer 112 or Alternatively, 90% or more of the platelets contained in the blood of the human body in the accommodation space 113 may be formed to have a size penetrating the first cover layer 111 or the second cover layer 112.

The plurality of micro-pores 114 can pass through platelets among components contained in the human body's blood accommodated in the receiving space 113 of the non-woven sheet 110 and the human body accommodated in the receiving space 113 of the non-woven sheet 110 Of the components contained in the blood of the larger size than platelets, such as red blood cells or incandescent cells will not pass.

Therefore, when the non-woven fabric sheet 110 containing the blood of the human body is arranged in the receiving space 113 on the wound surface 10, pressure is applied for a predetermined time, for example, 10 seconds to 30 seconds, such as pressing with hands. Among the components contained in the blood of the human body in the receiving space 113, the platelets are moved to the wound surface 10 through the plurality of micro holes 114, and among the components included in the blood of the human body in the receiving space 113 Components such as red blood cells or leukocytes of a larger size do not pass through the plurality of micro holes 114 and are not supplied to the wound surface 10. As a result, the concentration of platelets in the wound surface 10 is increased.

In addition, the platelets contained in the blood leaked from the wound surface 10 while the platelets are supplied to the wound surface 10 through a plurality of fine holes 114 among the components contained in the blood of the human body in the receiving space 113 Since it does not flow into the receiving space 113 through the plurality of fine holes 114, it does not fall off from the wound surface 10 and stays on the wound surface 10 as it is.

Therefore, the wound coating material 100 provided with the non-woven fabric sheet 110 having a plurality of fine holes 114 prevents platelets contained in blood leaking from the wound surface 10 from falling off the wound surface 10. And, as well as to stay on the wound surface, by supplying additional platelets to the wound surface 10, it significantly induces a blood clotting mechanism, thereby greatly promoting the natural hemostasis and healing process.

Platelets are a type of blood, which is a type of blood, and is a cell fragment having a diameter of about 2.0 μm or more and 3.0 μm or less, with the cytoplasm split from large cells in the bone marrow. Platelets play an important role in blood clotting and hemostasis.

When blood vessels are damaged and bleeding occurs on the skin or mucous membranes, platelets are activated first. When activated platelets adhere to damaged blood vessel walls and come into contact with air, the action of an enzyme called thrombokinase converts one of the plasma proteins, prothrombin to thrombin, and thrombin converts fibrinogen back into fibrin, causing fibrin to clot blood. The blood clots through.

In this way, blood platelets, which play an important role in coagulation or hemostasis of blood, are kept in the wound surface 10 as much as possible, and blood platelets contained in the blood in the receiving space 113 are additionally supplied to the wound surface 10 to coagulate blood. I want to promote the hemostatic effect as much as possible.

Here, it is preferable that the plurality of fine holes 114 are formed in the first cover layer 111. Thereby, platelets contained in the blood of the human body in the receiving space 113 can be directly supplied to the wound surface 10 through a plurality of fine holes 114 of the first cover layer 111 arranged on the wound surface 10 side. Therefore, most of the platelets contained in the blood of the human body in the receiving space 113 can be supplied without loss in the supply process to the wound surface 10. However, the present invention is not limited thereto, and the plurality of fine holes 114 may be formed in both the first cover layer 111 and the second cover layer 112. In this case, the window covering material 100 is conveniently and quickly arranged on the window surface 10 so as to face the window surface 10 without any distinction between the first cover layer 111 and the second cover layer 112. Since it is possible, it is possible to quickly respond to the first aid of the wound surface 10.

The average diameter of the plurality of micropores may be 3.0 μm or more and 5.0 μm or less. Through a plurality of micro-pores having an average diameter, platelets having a diameter of about 2.0 µm or more and 3.0 µm or less pass through, and red blood cells having a diameter of 7.0 µm or more and 8.0 µm or less and leukocytes having a diameter of 12.0 µm or more pass through It won't work. Therefore, after the wound surface is treated using the wound covering material 100, the concentration of red blood cells and white blood cells increases in the accommodation space 113 of the nonwoven sheet 110 of the wound covering material 100.

The method of allowing blood of the human body to be included in the accommodation space 113 formed by the first cover layer 111 and the second cover layer 112 may be variously made.

The first cover layer 111 or the second cover layer 112 may be formed with an inlet hole 115 through which blood of the human body flows into the receiving space 113. Through this inlet hole 115, blood from the human body can be injected into the receiving space 113 from the outside. Therefore, when the wound covering material 100 is not used, blood is not injected into the accommodation space 113 but blood is injected into the accommodation space 113 through the inlet hole 115 only when the wound covering material 100 is used. do.

Inlet hole 115 may be formed so that the injection needle 20, such as a butterfly needle (butterfly needle). After extracting self-extracting blood from the patient's own body using the injection needle 20, the injection needle 20 is penetrated into the accommodation space 113 through the inlet hole 115, and thus self-extracted into the accommodation space 113 Blood (B) can be injected. In this case, since self-extracting blood B is extracted from the patient and can be used for first aid of the wound surface 10, the first aid of the wound surface 10 can be quickly performed in the field.

The inlet hole 115 may be closed in various ways so that blood of the human body included in the accommodation space 113 does not leak. For example, the inlet hole 115 may be formed by an elastic member such as a rubber material in close contact with the injection needle 20 so that the inner surface of the inlet hole 115 is in close contact with the outer surface of the injection needle 20. In this case, a pressure is applied to the nonwoven sheet 110 in a state where the injection needle 20 enters the accommodation space 113 through the inlet hole 115, and the wound surface from the blood of the human body in the accommodation space 113 After the platelets have been fed to 10, the injection needle 20 can be removed from the receiving space 113. However, the present invention is not limited thereto, and the inlet hole 115 may be sealed by various other methods in which blood of the human body included in the accommodation space 113 does not leak.

The wound covering material 100 may further include a pressing member 120 which is arranged to cover the nonwoven sheet 110 while facing the wound surface 10.

The pressing member 120 presses the nonwoven sheet 110 so that platelets of the components contained in the blood of the human body in the receiving space 113 pass through the plurality of micro holes 114 to reach the wound surface 10. Thereby, the platen contained in the blood of the human body in the receiving space 113 can be easily guided to the wound surface 10 by easily pressing the nonwoven sheet 110 using the pressing member 120, and the nonwoven sheet In the process of pressing 110, the plasma components contained in the blood of the human body in the receiving space 113 are prevented from leaking to the outside, and the bacterial penetration into the wound surface 10 in the process of pressing the nonwoven sheet 110 It is possible to prevent.

The pressing member 120 may be made of various materials.

The pressing member 120 may include a plastic film material. The pressing member 120 including such a material, platelets flowing out toward the pressing member 120 among the platelets leaked through the plurality of micro holes 114 from the receiving space 113 by the pressing process of the non-woven sheet 110 It can be guided toward the wound surface 10, of course, it is possible to prevent the plasma component leaked through the plurality of micro-holes 114 from the receiving space 113 is leaked to the outside and exposed to the hands of the treatment, In the pressing process of the non-woven fabric sheet 110, it is possible to prevent the wound surface 10 or the non-woven fabric sheet 110 from being in direct contact by the operator. Therefore, the pressing member 120 can more efficiently achieve platelet guidance to the wound surface, prevention of external leakage of plasma components, and prevention of bacterial penetration into the wound surface.

The pressing member 120 may be detachably coupled to the nonwoven sheet 110. That is, after arranging the nonwoven sheet 110 on the wound surface for treatment on the wound surface 10, the pressing member 120 is arranged to cover the nonwoven sheet 110, and then the pressing member 120 can be pressed. have. However, it is not necessarily limited to this, and the pressing member 120 may be coupled so as not to be detachable from the nonwoven sheet 110. That is, for the treatment of the wound surface 10, the non-woven sheet 110 is pressed against the wound surface 10 so that the pressing member 120 is non-removably coupled to the wound non-woven sheet 110 wound coating material 100 After the arrangement, the pressing member 120 may be pressed.

When pressing the nonwoven sheet 110 by the pressing member 120 or directly pressing the nonwoven sheet 110 without being pressed by the pressing member 120, it is preferable to press for 10 seconds to 30 seconds. When pressed for a shorter time than this, platelets contained in the blood of the human body in the receiving space 113 of the nonwoven sheet 110 are difficult to be properly supplied to the wound surface 10 through the plurality of fine holes 114. In addition, when pressed for a longer time than this, the platelet contained in the blood of the human body in the receiving space 113 of the non-woven fabric sheet 110 is supplied to the wound surface 10 through a plurality of fine holes 114, then the wound surface It may fall off from (10) to another part or worsen the wound on the wound surface 10.

(Example 2)

This embodiment is a method of manufacturing a wound coating material having a non-woven fabric sheet having fine pores for blood coagulation, as illustrated in FIG. 6 by way of example.

The method for manufacturing a wound coating material (S100) of the present embodiment includes first preparing a first cover layer 111 arranged to face the wound surface 10 (S110).

Next, a second cover layer 112 arranged to face the wound surface 10 and opposite is prepared (S120).

Next, the first cover layer 111 and the second cover layer 112 are combined to form a receiving space 113 in which blood of the human body is accommodated (S130).

Here, the first cover layer 111 or the second cover layer 112 includes a plurality of fine holes 114.

The plurality of micro-pores 114, the components contained in the blood of the human body of the receiving space 113 to pass through the platelets and components of a size larger than the platelets do not pass, the average of the same or greater than the average diameter of the platelets It has a diameter and an average diameter that is smaller than a component of a size larger than platelets.

When the wound covering material 100 manufactured by this method is arranged and pressed on the wound surface 10, among the components included in the blood of the human body in the receiving space 113, platelets are wound through a plurality of fine holes 114. Since components supplied to the upper surface 10 and larger than platelets among the components contained in the blood of the human body in the accommodation space 113 do not pass through the plurality of micro holes 114, they are not supplied to the wound surface 10. , In the wound surface 10, the concentration of platelets is increased.

In addition, among the components contained in the blood of the human body in the receiving space 113, the platelets contained in the blood leaked from the wound surface 10 while the platelets are supplied to the wound surface 10 through a plurality of fine holes 114 It does not flow into the receiving space 113 through the plurality of fine holes 114 and stays on the wound surface 10.

Therefore, the wound covering 100 manufactured by this method prevents platelets contained in blood leaking from the wound surface 10 from falling off the wound surface 10 and stays on the wound surface 10. Of course, by additionally supplying platelets to the wound surface 10, it is possible to significantly induce a blood clotting mechanism, thereby greatly promoting a natural hemostasis and healing process.

The method of allowing blood of the human body to be included in the accommodation space 113 formed by the first cover layer 111 and the second cover layer 112 may be variously made.

The first cover layer 111 or the second cover layer 112 may be formed with an inlet hole 115 through which blood of the human body flows into the receiving space 113. Through this inlet hole 115, blood from the human body can be injected into the receiving space 113 from the outside. Therefore, when the wound covering material 100 is not used, blood is not injected into the accommodation space 113 but blood is injected into the accommodation space 113 through the inlet hole 115 only when the wound covering material 100 is used. do.

The present invention can be used for a wound coating material and a method for manufacturing the same.

10: Changsang-myeon
20: needle
100: wound covering material
110: non-woven sheet
111: first cover layer
112: second cover layer
113: accommodation space
114: fine hole
115: inlet hole
120: pressing member
20: needle

Claims (11)

A first cover layer arranged to face the wound surface; And
Arranged to face the wound surface, and provided with a nonwoven sheet comprising a second cover layer that is combined with the first cover layer to form a receiving space for receiving human blood,
The first cover layer or the second cover layer has an average diameter equal to or greater than the average diameter of the platelets so that platelets of the components contained in the blood of the human body in the receiving space pass through and components of a size larger than the platelets do not pass through. And contains a plurality of micropores with an average diameter smaller than the components of a size larger than platelets,
Wound covering material having a non-woven fabric sheet having fine pores for blood clotting. The method according to claim 1,
A plurality of fine holes are formed in the first cover layer, a wound coating material having a non-woven fabric sheet having fine pores for blood clotting. The method according to claim 1,
A plurality of fine holes are formed in the first cover layer and the second cover layer, a wound coating material having a non-woven fabric sheet having fine pores for blood clotting. The method according to claim 1,
A wound covering material having a nonwoven fabric sheet having fine pores for blood clotting, wherein the average diameter of the plurality of fine pores is 3.0 µm or more and 5.0 µm or less. The method according to claim 1,
A wound covering material having a non-woven fabric sheet having fine pores for blood clotting, in which a first cover layer or a second cover layer is formed with an inflow hole through which blood of the human body flows into the accommodation space. The method according to claim 5,
A wound covering material having a non-woven fabric sheet having fine pores for blood clotting, through which an injection needle for injecting human body blood passes through the inlet hole. The method according to claim 1,
Arranged to cover the nonwoven sheet while facing the wound surface, the pressing member for pressing the nonwoven sheet to allow the platelets to pass through the plurality of micropores and reach the wound surface among the components contained in the blood of the human body in the receiving space A wound coating material comprising a nonwoven sheet having fine pores for blood clotting. The method according to claim 7,
The pressing member comprises a plastic film (plastic film) material, a wound coating material provided with a non-woven fabric sheet having fine pores for blood clotting. The method according to claim 1,
The first cover layer or the second cover layer is polyethylene (poly ethylene), polypropylene (poly prophylene), polyurethane (poly urethane), teflon, silicone (silicone), PLA (poly lactic acid) , PLA (poly L-form lactic acid), PCL (polycarprolactone (PCL)), PGA (poly glycolic acid), PLA (pol lactic glycolic acid) (PLGA), methylcellulose ( methyl cellulose, hyaluronic acid, collagen, gelatin, lysine, alginate, elastine, fibronectine, cellulose, rayon Rayon) and natural pulp (natural pulp), including at least one selected from the group consisting of a wound coating material having a non-woven fabric sheet with micropores for blood clotting. Prepare a first cover layer arranged to face the wound surface,
Prepare a second cover layer which is arranged to face the wound surface and the opposite side,
And combining the first cover layer and the second cover layer to form an accommodation space in which blood of the human body is accommodated,
The first cover layer or the second cover layer has an average diameter equal to or greater than the average diameter of the platelets so that platelets of the components contained in the blood of the human body in the receiving space pass through and components of a size larger than the platelets do not pass through. And contains a plurality of micropores with an average diameter smaller than the components of a size larger than platelets,
A method for manufacturing a wound coating material having a non-woven fabric sheet having fine pores for blood clotting. The method according to claim 10,
The first cover layer or the second cover layer is a method for manufacturing a wound coating material having a non-woven fabric sheet having fine pores for blood clotting, in which an inflow hole through which blood of the human body flows is formed in a receiving space.

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