KR102069044B1 - 루비듐 용출 시스템 제어 - Google Patents
루비듐 용출 시스템 제어 Download PDFInfo
- Publication number
- KR102069044B1 KR102069044B1 KR1020157008617A KR20157008617A KR102069044B1 KR 102069044 B1 KR102069044 B1 KR 102069044B1 KR 1020157008617 A KR1020157008617 A KR 1020157008617A KR 20157008617 A KR20157008617 A KR 20157008617A KR 102069044 B1 KR102069044 B1 KR 102069044B1
- Authority
- KR
- South Korea
- Prior art keywords
- processor
- generator
- patient
- dissolution
- evaluation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000010828 elution Methods 0.000 title claims abstract description 78
- 229910052701 rubidium Inorganic materials 0.000 title description 25
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 title description 25
- 238000004090 dissolution Methods 0.000 claims abstract description 75
- 239000012530 fluid Substances 0.000 claims abstract description 40
- 238000011156 evaluation Methods 0.000 claims abstract description 33
- 230000009471 action Effects 0.000 claims abstract description 9
- 238000003908 quality control method Methods 0.000 claims abstract description 4
- 230000004044 response Effects 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 14
- 238000011010 flushing procedure Methods 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 8
- 230000007257 malfunction Effects 0.000 claims description 5
- 239000011358 absorbing material Substances 0.000 claims description 2
- 230000007246 mechanism Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 50
- 239000012267 brine Substances 0.000 description 39
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 39
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 27
- 239000002699 waste material Substances 0.000 description 13
- 230000006870 function Effects 0.000 description 10
- 239000011780 sodium chloride Substances 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 238000012544 monitoring process Methods 0.000 description 6
- 238000002600 positron emission tomography Methods 0.000 description 6
- 230000005855 radiation Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 238000012879 PET imaging Methods 0.000 description 4
- 230000002572 peristaltic effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000002285 radioactive effect Effects 0.000 description 4
- 238000012795 verification Methods 0.000 description 4
- JBLPUHBAIJVVMG-UHFFFAOYSA-N [Rb].[Sr] Chemical compound [Rb].[Sr] JBLPUHBAIJVVMG-UHFFFAOYSA-N 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- IGLNJRXAVVLDKE-OIOBTWANSA-N Rubidium-82 Chemical compound [82Rb] IGLNJRXAVVLDKE-OIOBTWANSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000002107 myocardial effect Effects 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000008215 water for injection Substances 0.000 description 2
- 230000005428 wave function Effects 0.000 description 2
- 208000032368 Device malfunction Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
- F04B49/06—Control using electricity
- F04B49/065—Control using electricity and making use of computers
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B15/00—Systems controlled by a computer
- G05B15/02—Systems controlled by a computer electric
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Automation & Control Theory (AREA)
- General Physics & Mathematics (AREA)
- Computer Hardware Design (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine (AREA)
- Measurement Of Radiation (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Sampling And Sample Adjustment (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261697244P | 2012-09-05 | 2012-09-05 | |
| US61/697,244 | 2012-09-05 | ||
| PCT/CA2012/001000 WO2014036627A1 (en) | 2012-09-05 | 2012-10-26 | Rubidium elution system control |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150084782A KR20150084782A (ko) | 2015-07-22 |
| KR102069044B1 true KR102069044B1 (ko) | 2020-01-22 |
Family
ID=50236395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157008617A Active KR102069044B1 (ko) | 2012-09-05 | 2012-10-26 | 루비듐 용출 시스템 제어 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US10943707B2 (https=) |
| EP (4) | EP3696824B1 (https=) |
| JP (3) | JP6148341B2 (https=) |
| KR (1) | KR102069044B1 (https=) |
| CN (2) | CN104798139B (https=) |
| AU (4) | AU2012389470B2 (https=) |
| BR (1) | BR112015004906A8 (https=) |
| CA (3) | CA2884077C (https=) |
| CL (1) | CL2015000548A1 (https=) |
| CR (1) | CR20150151A (https=) |
| CY (1) | CY1120118T1 (https=) |
| DK (3) | DK3309796T3 (https=) |
| DO (1) | DOP2015000048A (https=) |
| ES (3) | ES2662365T3 (https=) |
| HK (1) | HK1250549B (https=) |
| HR (1) | HRP20180467T1 (https=) |
| HU (1) | HUE037373T2 (https=) |
| IL (1) | IL237497B (https=) |
| IN (1) | IN2015DN01752A (https=) |
| LT (1) | LT2893540T (https=) |
| MX (2) | MX351398B (https=) |
| NO (1) | NO2904011T3 (https=) |
| PE (1) | PE20150665A1 (https=) |
| PL (1) | PL2893540T3 (https=) |
| PT (1) | PT2893540T (https=) |
| SG (3) | SG10201701766PA (https=) |
| SI (1) | SI2893540T1 (https=) |
| WO (1) | WO2014036627A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2662365T3 (es) | 2012-09-05 | 2018-04-06 | Jubilant Draximage, Inc. | Control del sistema de elución de rubidio |
| WO2017137869A1 (en) * | 2016-02-12 | 2017-08-17 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device and display device including the semiconductor device |
| CA3037431A1 (en) | 2016-09-20 | 2018-03-29 | Bracco Diagnostics Inc. | Systems and techniques for generating, infusing, and controlling radioisotope delivery |
| EP3338828A1 (en) * | 2016-12-21 | 2018-06-27 | MedTrace A/S | An infusion system and a method of delivering a liquid radioactive solution from a source to a recipient |
| KR20190137872A (ko) * | 2017-04-14 | 2019-12-11 | 주빌란트 드락스이미지 인크. | 루비듐 용출 시스템 |
| SG11202009326XA (en) * | 2018-03-28 | 2020-10-29 | Bracco Diagnostics Inc | Early detection of radioisotope generator end life |
| DK3776598T3 (da) * | 2018-03-28 | 2022-08-01 | Bracco Diagnostics Inc | Systemer og teknikker til kalibrering af radioisotopafgivelsessystemer ved hjælp af en gammadetektor |
| US11391853B2 (en) | 2018-06-20 | 2022-07-19 | BWXT Isotope Technology Group, Inc. | System and method for evaluating elution efficiency and radiopurity of tc-99m generators |
| AU2019325581A1 (en) * | 2018-08-22 | 2021-03-11 | Jubilant Draximage Inc. | 82Rb elution system control and configurations |
| DK3840688T3 (da) * | 2018-08-22 | 2024-10-28 | Jubilant Draximage Inc | 82Rb-ELUERINGSSYSTEM OG DOSISKALIBRATORKONFIGURATIONER |
| US11648343B2 (en) | 2018-10-23 | 2023-05-16 | Ottawa Heart Institute Research Corporation | Infusion procedure for enhancing image quality |
| KR102746982B1 (ko) * | 2018-10-24 | 2024-12-27 | 오타와 하트 인스티튜트 리서치 코포레이션 | 영상 품질을 향상시키기 위한 주입 절차 |
| DK3751584T3 (da) | 2019-03-29 | 2024-06-10 | Riccardo Santopietro | Sikkerhedsmekanismer til radiofarmaceutisk elueringssystem og elueringsfremgangsmåder |
| US11791060B2 (en) | 2019-03-29 | 2023-10-17 | Jubilant Draximage Inc. | Elution protocols and dosages for radiopharmaceutical elution system |
| US12573516B2 (en) | 2020-02-21 | 2026-03-10 | Bracco Diagnostics Inc. | Radioisotope generator early breakthrough detection |
| US20230093338A1 (en) * | 2020-02-28 | 2023-03-23 | Jubilant Pharma Holdings Inc. | Radiopharmaceutical generation and infusion systems |
| CA3221884A1 (en) * | 2021-06-11 | 2022-12-15 | Norman Lafrance | Expert scoring system for measurement of severity, treatment response and prognosis of peripheral arterial disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070213848A1 (en) * | 2006-03-10 | 2007-09-13 | Ottawa Heart Institute Research Corporation | Rubidium elution system control |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4562829A (en) * | 1983-02-28 | 1986-01-07 | E. R. Squibb & Sons, Inc. | Strontium-rubidium infusion system |
| US4585941A (en) * | 1983-02-28 | 1986-04-29 | E. R. Squibb & Sons, Inc. | Dosimetry system for strontium-rubidium infusion pump |
| JP3730720B2 (ja) | 1996-08-26 | 2006-01-05 | オリンパス株式会社 | 内視鏡装置用収納ケース |
| JP2002282362A (ja) | 2001-03-27 | 2002-10-02 | Teijin Ltd | 呼吸用気体供給装置 |
| WO2005083393A1 (en) | 2004-01-27 | 2005-09-09 | Arcana International, Inc. | System for the control, verification and recording of the performance of a radioisotope generator’s operations |
| US9627097B2 (en) * | 2004-03-02 | 2017-04-18 | General Electric Company | Systems, methods and apparatus for infusion of radiopharmaceuticals |
| WO2005087274A1 (en) | 2004-03-05 | 2005-09-22 | Xl Sci-Tech, Inc. | Particulate materials and compositions for radio therapy |
| US8071959B2 (en) * | 2005-12-21 | 2011-12-06 | Ottawa Heart Institute Research Corp. | Rubidium generator for cardiac perfusion imaging and method of making and maintaining same |
| EP2139541B1 (en) * | 2007-01-01 | 2018-04-11 | Bayer Healthcare LLC | Systems for integrated radiopharmaceutical generation, preparation, transportation, and administration |
| EP2135630B1 (en) * | 2007-04-09 | 2014-05-07 | Obshchestvo S Ogranichennoy Otvetstvennostiu "Nauchno Proizvodstvennaya Firma 'Pozitom-Pro'" | Automated strontium-rubidium infusion system |
| US8317674B2 (en) | 2008-06-11 | 2012-11-27 | Bracco Diagnostics Inc. | Shielding assemblies for infusion systems |
| US7862534B2 (en) | 2008-06-11 | 2011-01-04 | Bracco Diagnostics Inc. | Infusion circuit subassemblies |
| KR101696175B1 (ko) * | 2008-06-11 | 2017-01-23 | 브라코 다이어그노스틱스 아이엔씨. | 주입 시스템의 캐비넷 구조물 배열 |
| US9597053B2 (en) | 2008-06-11 | 2017-03-21 | Bracco Diagnostics Inc. | Infusion systems including computer-facilitated maintenance and/or operation and methods of use |
| SI2157583T1 (sl) * | 2008-08-18 | 2011-10-28 | Stichting Jeroen Bosch Ziekenhuis | Generator stroncija-82/rubidija-82, postopek za pripravo diagnostiäśnega sredstva, ki vsebuje rubidij-82, navedeno diagnostiäśno sredstvo in njegova uporaba v medicini |
| WO2011126522A2 (en) | 2009-12-07 | 2011-10-13 | Medi-Physics, Inc. | Multiple generator elution system |
| KR101803113B1 (ko) | 2010-04-09 | 2017-12-28 | 바이엘 헬쓰케어 엘엘씨 | 방사성의약품 농도 측정 시스템 및 방법 |
| ES2662365T3 (es) | 2012-09-05 | 2018-04-06 | Jubilant Draximage, Inc. | Control del sistema de elución de rubidio |
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2012
- 2012-10-26 ES ES12884208.5T patent/ES2662365T3/es active Active
- 2012-10-26 KR KR1020157008617A patent/KR102069044B1/ko active Active
- 2012-10-26 SG SG10201701766PA patent/SG10201701766PA/en unknown
- 2012-10-26 CN CN201280075656.9A patent/CN104798139B/zh not_active Expired - Fee Related
- 2012-10-26 HU HUE12884208A patent/HUE037373T2/hu unknown
- 2012-10-26 SG SG11201501533RA patent/SG11201501533RA/en unknown
- 2012-10-26 CA CA2884077A patent/CA2884077C/en active Active
- 2012-10-26 ES ES20166557T patent/ES2959671T3/es active Active
- 2012-10-26 EP EP20166557.7A patent/EP3696824B1/en active Active
- 2012-10-26 WO PCT/CA2012/001000 patent/WO2014036627A1/en not_active Ceased
- 2012-10-26 SG SG10201809500WA patent/SG10201809500WA/en unknown
- 2012-10-26 PT PT128842085T patent/PT2893540T/pt unknown
- 2012-10-26 LT LTEP12884208.5T patent/LT2893540T/lt unknown
- 2012-10-26 MX MX2015002771A patent/MX351398B/es active IP Right Grant
- 2012-10-26 DK DK17200924.3T patent/DK3309796T3/da active
- 2012-10-26 EP EP12884208.5A patent/EP2893540B1/en not_active Revoked
- 2012-10-26 CN CN201710874145.8A patent/CN107658040B/zh not_active Expired - Fee Related
- 2012-10-26 EP EP17200924.3A patent/EP3309796B1/en active Active
- 2012-10-26 PE PE2015000302A patent/PE20150665A1/es active IP Right Grant
- 2012-10-26 PL PL12884208T patent/PL2893540T3/pl unknown
- 2012-10-26 AU AU2012389470A patent/AU2012389470B2/en active Active
- 2012-10-26 EP EP23185636.0A patent/EP4249006A3/en active Pending
- 2012-10-26 IN IN1752DEN2015 patent/IN2015DN01752A/en unknown
- 2012-10-26 CA CA3086464A patent/CA3086464C/en active Active
- 2012-10-26 US US14/426,208 patent/US10943707B2/en active Active
- 2012-10-26 CA CA3174806A patent/CA3174806A1/en active Pending
- 2012-10-26 DK DK20166557.7T patent/DK3696824T3/da active
- 2012-10-26 DK DK12884208.5T patent/DK2893540T3/en active
- 2012-10-26 SI SI201231231T patent/SI2893540T1/en unknown
- 2012-10-26 ES ES17200924T patent/ES2803514T3/es active Active
- 2012-10-26 BR BR112015004906A patent/BR112015004906A8/pt active Search and Examination
- 2012-10-26 HR HRP20180467TT patent/HRP20180467T1/hr unknown
- 2012-10-26 JP JP2015528816A patent/JP6148341B2/ja active Active
- 2012-10-26 MX MX2017013172A patent/MX385226B/es unknown
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2013
- 2013-10-02 NO NO13774596A patent/NO2904011T3/no unknown
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2015
- 2015-03-02 IL IL237497A patent/IL237497B/en active IP Right Grant
- 2015-03-04 DO DO2015000048A patent/DOP2015000048A/es unknown
- 2015-03-05 CL CL2015000548A patent/CL2015000548A1/es unknown
- 2015-03-19 CR CR20150151A patent/CR20150151A/es unknown
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2017
- 2017-05-18 JP JP2017098710A patent/JP2017138338A/ja not_active Withdrawn
- 2017-08-14 AU AU2017213596A patent/AU2017213596C1/en active Active
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2018
- 2018-04-04 CY CY20181100379T patent/CY1120118T1/el unknown
- 2018-07-31 HK HK18109891.1A patent/HK1250549B/zh not_active IP Right Cessation
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2019
- 2019-05-24 AU AU2019203648A patent/AU2019203648A1/en not_active Abandoned
- 2019-06-07 JP JP2019106743A patent/JP6684945B2/ja active Active
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2021
- 2021-02-11 US US17/173,874 patent/US11699535B2/en active Active
- 2021-04-15 AU AU2021202275A patent/AU2021202275A1/en not_active Abandoned
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2023
- 2023-04-18 US US18/302,663 patent/US20240055148A1/en not_active Abandoned
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2025
- 2025-01-14 US US19/019,981 patent/US12451265B2/en active Active
- 2025-10-21 US US19/364,429 patent/US20260045381A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070213848A1 (en) * | 2006-03-10 | 2007-09-13 | Ottawa Heart Institute Research Corporation | Rubidium elution system control |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102069044B1 (ko) | 루비듐 용출 시스템 제어 | |
| KR20190137872A (ko) | 루비듐 용출 시스템 | |
| HK1250549A1 (en) | Rubidium elution system | |
| JP2015531870A5 (https=) | ||
| HK1254331B (en) | Rubidium elution system control | |
| HK1211381B (en) | Rubidium elution system control |
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Comment text: Notification of reason for refusal Patent event date: 20190111 Patent event code: PE09021S01D |
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Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20191024 |
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