KR102048883B1 - Composition for scalp and hair containing disodium R-sugar-sulfosuccinate - Google Patents

Abstract

The present invention relates to a composition for scalp or hair, and more particularly, by using disodium R-glucose-sulfosuccinate as a surfactant, the scalp is stabilized by stabilizing sensitive, irritant or reactive scalp. It relates to a scalp or a composition for hair that can make healthy and thereby strengthen the hair and strengthen the hair root.

Description

Composition for scalp and hair containing disodium R-sugar-sulfosuccinate}

The present invention relates to a composition for scalp or hair, and more particularly, by using disodium R-sugar-sulfosuccinate as a surfactant, the scalp is stabilized by stabilizing sensitive, irritant or reactive scalp. It relates to a scalp or a composition for hair that can make healthy and thereby strengthen the hair and strengthen the hair root.

Human scalp has a lot of waste due to contaminants left in the pores, such as sebum, sweat, dust and styling agents. In addition, due to the use of dyeing, perm, hair dryer, etc. as well as hair dry scalp, many scalp is produced, causing many people to worry. If the keratin of the scalp is not removed, dandruff is generated, and the dandruff usually irritates the scalp and is accompanied by itching. At this time, irritating or scratching the scalp hurts and eventually causes inflammation to cause eczema, hair loss.

In order to remove the contamination of hair and scalp and keep it clean and beautiful, shampoos commonly used include anionic surfactants with excellent cleaning power, and generally use highly anionic alkyl sulfate surfactants with high foaming ability. have.

However, cleaning products such as shampoos using such anionic alkyl sulfate surfactants have high irritation to the skin due to the strong detergency and degreasing power.

Korean Laid-Open Patent No. 2013-0016513

Accordingly, the present inventors have studied hair compositions that can provide a sedative effect when used on the scalp, and as a result, when disodium R-sugar-sulfosuccinate is used as a surfactant, the irritation to the scalp can be reduced as well. The present invention was completed by discovering that the hair root can be strengthened to give elasticity to the hair.

Accordingly, it is an object of the present invention to provide a scalp or hair composition that can effectively reduce irritation to the scalp to soothe hair and impart strength to the hair.

In order to achieve the above object, the present invention provides a composition for scalp or hair containing disodium R-sugar-sulfosuccinate.

The scalp or hair composition according to the present invention has a remarkably small irritation to the scalp and has excellent scalp waste removal and exfoliation effect, stabilizes sensitive, irritant or reactive scalp, thereby strengthening the hair root and helping to enhance hair elasticity. Becomes

The present invention provides a composition for scalp or hair containing disodium R-sugar-sulfosuccinate as an active ingredient.

Anionic surfactants, which have conventionally been used in scalp or hair compositions, have irritation to the scalp, and thus are not suitable for use in sensitive scalp. In order to solve this problem, the present invention uses disodium R-sugar-sulfosuccinate as a surfactant.

In the disodium R-sugar-sulfosuccinate used in the present invention, the types of sugars include, but are not limited to, for example, glucose, galactose, lactose, maltose, fructose, xylose, sucrose and cellulose. One or more selected from the group consisting of can be used.

In addition, in the disodium R-sugar-sulfosuccinate used in the present invention, the kind of the R group is not particularly limited, but, for example, cetearyl, cetyl, coco, isodecyl, isostear. One or more selected from the group consisting of aryl, lauryl, lauryl ether (laures), myristamido MEA (mercaptoethylamine; mercaptoethylamine), stearyl and tridecyl can be used in the present invention.

The composition of the present invention contains disodium R-sugar-sulfosuccinate in an amount of at least 1% by weight, preferably at least 5% by weight, more preferably at least 10% by weight relative to the total weight of the composition. In addition, the composition of the present invention contains disodium R-sugar-sulfosuccinate in an amount of 80% by weight or less, preferably 70% by weight or less, more preferably 40% by weight or less, based on the total weight of the composition. In addition, the composition of the present invention comprises disodium R-sugar-sulfosuccinate in an amount of 1 to 80% by weight, preferably 5 to 70% by weight, more preferably 10 to 40% by weight or more, based on the total weight of the composition. It contains. This is because if the content is less than 1% by weight, the stability of the product is impaired, and if it is more than 80% by weight, there is a possibility that precipitation of the product may occur.

The composition according to the present invention can stabilize the sensitive, irritant or reactive scalp by reducing irritation phenomena such as itching and stinging of the scalp that may appear during staining and chemical treatment such as perm and alleviating scalp inflammation. In addition, by providing a conditioning effect to soften and smooth the rough and damaged hair caused by the chemical procedure can improve the hair condition healthily.

The composition of the present invention is not particularly limited in formulating, but may be formulated as hair tonic, hair nourishing longevity, scalp treatment, hair treatment, hair rinse, hair shampoo, hair lotion, or scalp hair treatment. have.

In addition, in each formulation, other ingredients in addition to the above-mentioned essential ingredients may be appropriately selected and blended by those skilled in the art without difficulty according to the kind or purpose of use of other external preparations.

The composition of the present invention can be used according to a conventional method of use, and the frequency and amount of use may vary depending on the user's scalp state or taste.

Hereinafter, although an Example and a test example are given and demonstrated more concretely of this invention, this invention is not limited only to these examples.

Reference Example 1 Ocular mucosal stimulation test (HET-CAM test)

The specific method of eye mucosal stimulation test used in the following test example is as follows.

The Hen? Egg Test on the Chorioallantoic Membrane (HET-CAM) test is an alternative to the Rabbit draize eye irritation test in rabbits to assess the degree of acute irritation of the test substance. It is a test method to do this.

This test represents the degree of vascular response of the conjunctiva of the eye by the substance and is achieved by applying the test substance to the chorioallantoic membrane (CAM) of fertilized cultured eggs. Fresh, natively shaped eggs from the white horn are used for this test.

1. Eye Correction ( calibration )

The oviposition status is the stimulus threshold according to the degree of stimulation, using Texapon Asv® (Cognis, sodium magnesium lauryl-myristyl-6-ethoxy-sulfate; anionic surfactant) as an internal benchmark substance at each acquisition. The value was determined.

At this time, 5% Texapon Asv® is the OCED guideline No. A moderate stimulus in the Draize rabbit eye test according to 405 and classified under R36 in accordance with EU Directives (EC, 1991).

0.5% weakness Bleeding and fusion 1.0% middle Bleeding and fusion 5.0% Strong Bleeding and fusion

According to the concentrations given in Table 1 above, apply to at least two eggs and then visually check the reaction parameters at that time to maintain a constant criterion, and the category of the degree described was determined as an application period of 5 minutes. It becomes the standard of evaluation.

2. Pre-test Preliminary test )

① The preliminary experiment shall be conducted to determine whether the experiment should be a reaction time measurement method or a termination reaction evaluation method.

② Drop the test substance into the prepared egg.

Liquid: 300 μl

(** SOP Basis Paper: If solid, drop enough to cover at least 25% of membrane)

③ After applying the test substance, check that hemorrhage, lysis and coagulation (intravascular / extravascular) of capillaries occur.

④ For solid, cream, colored or non-permeable test materials, react for 30 seconds, wash with physiological saline for 20 seconds, and observe the test observer for a certain period of time (eg, 3 minutes). After the reaction is classified according to the criteria for the reaction of Table 2 below.

Degree of specific effect Influence value 0 none One weakness 2 middle 3 Severe

** Before entering the experiment, confirm that it meets the following requirements.

O The reaction time measurement method should not be obstructed in the observation of the entire CAM by the test substance applied when the test substance is applied (the field of view of the entire CAM must be secured).

㈁ In the case of termination reaction evaluation method, when the test substance is applied to CAM and washed with physiological saline, it should be a substance which can be separated from the membrane.

When the test substance is used, it is applied to the standard of Table 2 after observing at least 30 seconds after washing with physiological saline.

3. Experiment

1) the reaction time measuring method (Reaction time method )

① Use 6 eggs for each test substance.

② Prepare three or more stopwatches.

③ If the bleeding and fusion reactions occurred in the preliminary test, two stopwatches are held in the left hand and the stopwatch is operated as soon as 300 μl of the material in the pipette of the right hand is applied to the CAM.

④ Carefully observe and stop the stopwatch when bleeding and fusion first appear and record on the paper in seconds.

⑤ If the solidification reaction occurs, stop only one of the two stopwatches and observe the time of fusion with the other one. Then measure the time until solidification occurs without stopping.

⑥ After completion of recording of 6 eggs, the stimulus index is calculated using Excel program (described in detail below).

⑦ On the day of the experiment, observe the eyes of each observer for each parameter by performing the same method with 5% concentration of the anionic surfactant Texapon Asv® (sodium magnesium lauryl-myristyl-6-ethoxy-sulfate), which is the recommended substance in the laboratory. It should always be calibrated. This recommendation is a reference material and is used as a reference material in evaluating the stimulus index. The concentration of material used was found to be a moderate stimulus in the Draze eye irritation experiment.

Distinguish Vascular Response phenomenon Explanation bleeding Bleeding from blood vessels
(Similar to snow crystals that can be seen when looking at the microscope) Fusion Small vessels disappear on CAM
(Result: bleeding, dystonia of microvascular, or collapse) coagulation Intravascular coagulation (thrombosis) or extravascular coagulation of proteins
(It looks as if the egg protein is cloudy with heat. To see the vascular changes remarkably, treatment with 3% trichloroacetic acid is certain.)

2) End - time evaluation method assessment )

① If the CAM cannot be observed because it is a non-permeable material, the termination reaction evaluation method is implemented.

② Use 6 prepared eggs per test substance in the same way as the reaction time measurement method.

③ Press the stopwatch after applying the material.

④ After 30 seconds of stagnation, reach 30 seconds, carefully wash the CAM with physiological saline for 20 seconds. At this time, be careful not to tear the CAM by washing too hard with saline.

⑤ If the blood is mixed together during the material treatment period, it will be washed together during the washing, so the response should be evaluated 30 seconds after washing.

⑥ Distinguish the degree of each reaction in the same way as the previous experiment and follow the list in Table 4.

0 = none
1 = weak
2 = medium
3 = strong response

4. Result calculation

1) Q value (Q- value )

① In order to evaluate the degree of stimulation by measuring the response time, the ratio (Q) between the stimulus index of the test substance and the recommended substance should be calculated. The formula for calculating the Q value is as follows, and is calculated using a specially designed Excel program.

② For example, if Q is greater than 1, the substance is a stronger stimulant than the recommended substance, and if it is less than 1, it is a corresponding stimulant.

*** If the Q value is greater than or equal to 1.2, the substance has a stimulus in vivo; if the Q value is greater than or equal to 2.0, the substance has a severe stimulus in vivo.

*** The cutoff of the Q value is 2.5, and the value above this value is dif- ficult to distinguish.

More detailed conversion score determination tables are summarized in Table 5 below.

③ Assessment of stimulus level using IS value

Q values obtained from observations are often short (0.8 to 2.0), so in the case of reactions with short reaction times, the distinction is often difficult because the difference is not sufficiently reflected in the values. The IS value is calculated using different calculations from the same raw data, and as the interval is longer (0 to 21), it is easy to distinguish the difference in stimulus level from substance to substance.

The IS value is calculated using the formula 300 [ IS ] = 5 [301-H] +7 [301-L] +9 [301-C] and has a value between 0 and 21 (H, L, C is Starting time for each reaction to be observed for observation times up to 300 seconds).

A more detailed conversion score determination table is summarized in Table 5 above.

④ The evaluation by the termination response evaluation method is expressed as the sum [S] value of each observation item. Can be classified as having. If a response is classified as strong (when the sum of all scores is 16 or more), it indicates a severe stimulus in vivo. In other cases, the stimulus property is low in vivo.

More detailed conversion score determination tables are summarized in Table 5 above.

⑤ In order to evaluate the degree of stimulation of a non-permeable substance, the test substance should be dissolved in water and calculated by reaction time measurement at the highest concentration.

⑥ The final judgment on the possibility of irritation of the test substance should be made as the worst of the two methods. For example, if the Q value of the diluted permeable substance is found to be more irritating than the S value of the undiluted test substance, then the Q value is determined.

5. Test record

① Not only the response of CAM observed each time, but also the data of egg feeding should be recorded.

② Record in detail all test and test methods of this experiment.

③ The choice of solvent and diluent is especially important.

④ If the test or evaluation method cannot be done by the reaction time measurement method or the termination reaction evaluation method (for example, adhesive type) due to the physical or material properties, this experiment cannot be done naturally.

Test Example 1 Ocular mucosal stimulation test (HET-CAM test) of the active ingredient

In the method described in Reference Example 1 above, representative anionic surfactants such as cocamidopropyl betaine, disodium laureth sulfosuccinate, ammonium laureth sulfate and ammonium lauryl sulfate and the disodium R- used in the present invention The stimulation index for sugar sulfosuccinate was measured. The results are shown in Table 6 below.

Raw material name Test concentration Stimulus index Judgment Cocamidopropyl Betaine One% Q = 1.69 Stimulation Disodium laureth sulfosuccinate One% Q = 0.71 Slightly irritating Ammonium Laureth Sulfate One% Q = 1.26 Stimulation Ammonium Lauryl Sulfate One% Q = 1.22 Stimulation Disodium coco-glucose-sulfosuccinate One% Q = 0.70 Slightly irritating Disodium cetyl-galactose-sulfosuccinate One% Q = 0.69 Slightly irritating Disodium Stearyl-Lactose-Sulfosuccinate One% Q = 0.74 Slightly irritating Disodium laureth-maltose-sulfosuccinate One% Q = 0.76 Slightly irritating Disodium Cetearyl-Fructose-Sulfosuccinate One% Q = 0.61 Slightly irritating Disodium Isodecyl-Xylose-Sulfosuccinate One% Q = 0.71 Slightly irritating Disodium Lauryl-Sucrose-Sulfosuccinate One% Q = 0.76 Slightly irritating Disodium myristomido MEA-cellulose-sulfosuccinate One% Q = 0.73 Slightly irritating

As a result of the ocular mucosal irritation test, it was determined that the dissodium R-sugar-sulfosuccinate type of surfactant was lower than that of the representative anionic surfactant as shown in Table 6 above.

In addition, it can be seen from the above results that the degree of stimulation is low regardless of the R group and the type of sugar in disodium R-sugar-sulfosuccinate.

[Examples and Comparative Examples 1-2] Preparation of the scalp or hair cosmetic composition

To prepare a shampoo in the composition of Table 7. The examples contain disodium R-sugar-sulfosuccinate as surfactant, and Comparative Examples 1 and 2 use ammonium laureth sulfate / ammonium lauryl sulfate as surfactant (unit: wt%).

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Purified water To 100 To 100 To 100 To 100 To 100 Disodium ID 0.05 0.05 0.05 0.05 0.05 Sodium salicylate 0.2 0.2 0.2 0.2 0.2 Sodium citrate 0.1 0.1 0.1 0.1 0.1 Disodium laureth sulfosuccinate 30 30 30 30 30 Ammonium Laureth Sulfate - - - - - Ammonium Lauryl Sulfate - - - - - Disodium coco glucoside sulfosuccinate (active ingredient 45%) (disodium coco-glucose-sulfosuccinate) 5 - - - - Disodium cetyl-galactose-sulfosuccinate - 5 - - - Disodium Stearyl-Lactose-Sulfosuccinate - - 5 - - Disodium laureth-maltose-sulfosuccinate - - - 5 - Disodium Cetearyl-Fructose-Sulfosuccinate - - - - 5 Disodium Isodecyl-Xylose-Sulfosuccinate - - - - - Disodium Lauryl-Sucrose-Sulfosuccinate - - - - - Disodium myristomido MEA-cellulose-sulfosuccinate - - - - - Cocamidopropyl Betaine 15 15 15 15 15 Chlorhexidine 2 2 2 2 2 silicon 2.2 2.2 2.2 2.2 2.2 incense One One One One One antiseptic 0.23 0.23 0.23 0.23 0.23 pH regulator 0.1 0.1 0.1 0.1 0.1 Viscosity modifier 0.1 0.1 0.1 0.1 0.1

ingredient Example 6 Example 7 Example 8 Comparative Example 1 Comparative Example 2 Purified water To 100 To 100 To 100 To 100 To 100 Disodium ID 0.05 0.05 0.05 0.05 0.05 Sodium salicylate 0.2 0.2 0.2 0.1 0.2 Sodium citrate 0.1 0.1 0.1 0.4 0.1 Disodium laureth sulfosuccinate 30 30 30 Ammonium Laureth Sulfate - - - 32 21 Ammonium Lauryl Sulfate - - - 27 30 Disodium coco glucoside sulfosuccinate (active ingredient 45%) (disodium coco-glucose-sulfosuccinate) - - - - - Disodium cetyl-galactose-sulfosuccinate - - - - - Disodium Stearyl-Lactose-Sulfosuccinate - - - - - Disodium laureth-maltose-sulfosuccinate - - - - - Disodium Cetearyl-Fructose-Sulfosuccinate - - - - - Disodium Isodecyl-Xylose-Sulfosuccinate 5 - - - - Disodium Lauryl-Sucrose-Sulfosuccinate - 5 - - - Disodium myristomido MEA-cellulose-sulfosuccinate - - 5 - - Cocamidopropyl Betaine 15 15 15 - 15 Chlorhexidine 2 2 2 - 2 silicon 2.2 2.2 2.2 2.2 One incense One One One One One antiseptic 0.23 0.23 0.23 0.23 0.23 pH regulator 0.1 0.1 0.1 0.1 0.1 Viscosity modifier 0.1 0.1 0.1 0.1 0.1

Test Example 2 Ocular mucosal irritation test of the scalp or hair cosmetic composition (HET-CAM test)

The ocular mucosa stimulation test was performed using the method described in Reference Example 1 to Examples 1 to 8 and Comparative Examples 1 to 2, and the results are shown in Table 9 below.

division Test concentration Stimulus index Judgment Example 1 5% Q = 0.19 Slightly irritating Example 2 5% Q = 0.12 Slightly irritating Example 3 5% Q = 0.13 Slightly irritating Example 4 5% Q = 0.21 Slightly irritating Example 5 5% Q = 0.33 Slightly irritating Example 6 5% Q = 0.11 Slightly irritating Example 7 5% Q = 0.34 Slightly irritating Example 8 5% Q = 0.10 Slightly irritating Comparative Example 1 5% Q = 0.73 Slightly irritating Comparative Example 2 5% Q = 0.9 Stimulation

As can be seen in Table 9, the composition using disodium R-sugar-sulfosuccinate as a surfactant according to the present invention is excellent in relieving ocular mucosa irritation effect, compared to the case of using the conventional anionic surfactant It can be seen that it can reduce the irritation to the skin.

In addition, it can be seen from the above results that the irritation-releasing effect is excellent regardless of the R group and the type of sugar in disodium R-sugar-sulfosuccinate.

Test Example 3 Sensory Test

The sensory test was carried out on the compositions of Examples 1 to 8 and Comparative Examples 1 to 2 as follows. Ten expert evaluation personnel were allowed to use Examples 1 to 8 and Comparative Examples 1 and 2 to perform a comparative test on the evaluation items shown in Table 10 below, with the lowest score being 1 and the highest score. The test was conducted with 5. The test results are shown in Table 10 below.

Item Itchy scalp Scalp irritation Hair softness / smoothness Example 1 2 One 2 Example 2 One 2 2 Example 3 2 2 2 Example 4 One One 2 Example 5 2 One 2 Example 6 2 One 2 Example 7 2 2 2 Example 8 2 2 2 Comparative Example 1 3 4 3 Comparative Example 2 4 4 3

In Table 10, when the compositions according to the present invention were used in Examples 1 to 8, itching of the scalp was reduced, irritation was also reduced, and the hair condition was better than in the case of using Comparative Examples 1 to 2. Able to know.

Claims (7)

As a cosmetic composition for the scalp or hair containing sulfosuccinate surfactant as an active ingredient,
The sulfosuccinate surfactants include disodium coco glucoside sulfosuccinate, disodium cetyl-galactose-sulfosuccinate, disodium stearyl-lactose-sulfosuccinate, disodium laureth-maltose-sulfosite Sinate, Disodium Cetearyl-Fructose-Sulfosuccinate, Disodium Isodecyl-Xylose-Sulfosuccinate, Disodium Lauryl-Sucrose-Sulfosuccinate and Disodium Myristamido MEA- Any one selected from the group consisting of cellulose-sulfosuccinate,
The composition is for improving the condition of the sensitive scalp or damaged hair, characterized in that for scalp or hair cosmetic composition. According to claim 1, wherein the content of sulfosuccinate surfactant is 1 to 80% by weight based on the total weight of the composition, scalp or hair cosmetic composition. delete The method of claim 1, wherein the damaged hair condition improvement is any one or more selected from the improvement of elasticity of the damaged hair, the softness of the damaged hair and the smoothness of the damaged hair, scalp or hair cosmetic composition. delete The method of claim 1, wherein the sensitive scalp condition improvement is characterized in that the scalp itching, scalp irritation reduction, or both, the scalp or hair cosmetic composition. The composition according to any one of claims 1, 2, 4 and 6, wherein the composition is a hair tonic, a hair nourishing cosmetic, a scalp treatment, a hair treatment, a hair rinse, a hair shampoo, a hair lotion or a scalp. A cosmetic composition for scalp or hair, characterized in that it is formulated as a hair treatment.