KR102000332B1 - 간내 담즙정체성 질환의 치료 - Google Patents

간내 담즙정체성 질환의 치료 Download PDF

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Publication number
KR102000332B1
KR102000332B1 KR1020167025636A KR20167025636A KR102000332B1 KR 102000332 B1 KR102000332 B1 KR 102000332B1 KR 1020167025636 A KR1020167025636 A KR 1020167025636A KR 20167025636 A KR20167025636 A KR 20167025636A KR 102000332 B1 KR102000332 B1 KR 102000332B1
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South Korea
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mbx
intrahepatic
disease
pharmaceutical composition
treatment
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Korean (ko)
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KR20160125424A (ko
Inventor
폴 뷰즈
찰스 에이 맥위어터
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사이머베이 쎄라퓨틱스, 인코퍼레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167025636A 2014-03-20 2015-03-19 간내 담즙정체성 질환의 치료 Active KR102000332B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461968037P 2014-03-20 2014-03-20
US61/968,037 2014-03-20
PCT/US2015/021502 WO2015143178A1 (en) 2014-03-20 2015-03-19 Treatment of intrahepatic cholestatic diseases

Publications (2)

Publication Number Publication Date
KR20160125424A KR20160125424A (ko) 2016-10-31
KR102000332B1 true KR102000332B1 (ko) 2019-07-15

Family

ID=52808186

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167025636A Active KR102000332B1 (ko) 2014-03-20 2015-03-19 간내 담즙정체성 질환의 치료

Country Status (32)

Country Link
US (5) US9486428B2 (https=)
EP (1) EP3119384B1 (https=)
JP (1) JP6568577B2 (https=)
KR (1) KR102000332B1 (https=)
CN (1) CN106102734B (https=)
AU (1) AU2015231232B2 (https=)
BR (1) BR112016020260A8 (https=)
CA (1) CA2941401C (https=)
CL (1) CL2016002338A1 (https=)
CY (1) CY1120927T1 (https=)
DK (1) DK3119384T3 (https=)
EA (1) EA032358B1 (https=)
ES (1) ES2701094T3 (https=)
FI (1) FIC20253004I1 (https=)
FR (1) FR25C1031I2 (https=)
HR (1) HRP20181914T1 (https=)
HU (2) HUE041733T2 (https=)
IL (1) IL247920B (https=)
LT (2) LT3119384T (https=)
MX (1) MX367478B (https=)
NL (1) NL301338I2 (https=)
NO (1) NO2025035I1 (https=)
NZ (1) NZ724057A (https=)
PH (1) PH12016501769B1 (https=)
PL (1) PL3119384T3 (https=)
PT (1) PT3119384T (https=)
RS (1) RS57970B1 (https=)
SI (1) SI3119384T1 (https=)
SM (1) SMT201800690T1 (https=)
UA (1) UA120756C2 (https=)
WO (1) WO2015143178A1 (https=)
ZA (1) ZA201606043B (https=)

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US10272058B2 (en) 2014-03-20 2019-04-30 Cymabay Therapeutics, Inc. Treatment of intrahepatic cholestatic diseases
KR102374499B1 (ko) 2014-04-11 2022-03-14 사이머베이 쎄라퓨틱스, 인코퍼레이티드 Nafld 및 nash 의 치료
US10512622B2 (en) 2017-07-14 2019-12-24 Cymabay Therapeutics, Inc. Treatment of intrahepatic cholestatic diseases
DK3973959T3 (da) 2017-09-26 2025-01-20 Cymabay Therapeutics Inc Behandling af kolestatisk kløe med seladelpar
EP3880187A1 (en) * 2018-11-16 2021-09-22 CymaBay Therapeutics, Inc. Treatment of obesity and its complications
JP7731868B2 (ja) 2019-08-02 2025-09-01 エースロット，インコーポレイテッド ＴＤＰ－４３、α－シヌクレイン、ハンチンチンタンパク質及びタウタンパク質のオリゴマー形成に関連する疾患を治療するための小分子薬物、並びに関連する方法
US20210145774A1 (en) 2019-11-14 2021-05-20 Cymabay Therapeutics, Inc. Treatment of alcoholic liver disease
WO2021097034A1 (en) 2019-11-14 2021-05-20 Cymabay Therapeutics, Inc. Seladelpar for use in the treatment of intestinal barrier dysfunction and associated diseases
US20220241228A1 (en) 2021-02-01 2022-08-04 Cymabay Therapeutics, Inc. Treatment of cholangiopathies

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DK3973959T3 (da) 2017-09-26 2025-01-20 Cymabay Therapeutics Inc Behandling af kolestatisk kløe med seladelpar
EP3880187A1 (en) 2018-11-16 2021-09-22 CymaBay Therapeutics, Inc. Treatment of obesity and its complications
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Publication number Publication date
US9808436B2 (en) 2017-11-07
CA2941401A1 (en) 2015-09-24
FR25C1031I2 (fr) 2026-03-27
US20180036268A1 (en) 2018-02-08
CY1120927T1 (el) 2019-12-11
US11406611B2 (en) 2022-08-09
NZ724057A (en) 2018-09-28
DK3119384T3 (en) 2018-12-03
SMT201800690T1 (it) 2019-01-11
US20150265560A1 (en) 2015-09-24
WO2015143178A1 (en) 2015-09-24
LTPA2025529I1 (https=) 2025-08-25
US10220011B2 (en) 2019-03-05
CN106102734A (zh) 2016-11-09
ES2701094T3 (es) 2019-02-20
US20210023031A1 (en) 2021-01-28
EA201691887A1 (ru) 2017-03-31
BR112016020260A2 (pt) 2017-08-15
LT3119384T (lt) 2018-11-26
NO2025035I1 (no) 2025-08-01
RS57970B1 (sr) 2019-01-31
US20170014363A1 (en) 2017-01-19
IL247920B (en) 2019-03-31
HUE041733T2 (hu) 2019-05-28
HUS2500033I1 (hu) 2025-09-28
PT3119384T (pt) 2018-12-12
AU2015231232B2 (en) 2018-08-02
KR20160125424A (ko) 2016-10-31
CL2016002338A1 (es) 2017-04-21
EP3119384A1 (en) 2017-01-25
FR25C1031I1 (fr) 2025-09-26
PH12016501769A1 (en) 2017-01-09
US20190192459A1 (en) 2019-06-27
FIC20253004I1 (fi) 2025-07-31
CN106102734B (zh) 2019-05-14
MX367478B (es) 2019-08-23
CA2941401C (en) 2019-06-11
EA032358B1 (ru) 2019-05-31
AU2015231232A1 (en) 2016-09-22
BR112016020260A8 (pt) 2021-06-29
JP6568577B2 (ja) 2019-08-28
UA120756C2 (uk) 2020-02-10
PH12016501769B1 (en) 2017-01-09
HRP20181914T1 (hr) 2019-01-11
JP2017508817A (ja) 2017-03-30
PL3119384T3 (pl) 2019-03-29
SI3119384T1 (sl) 2018-12-31
EP3119384B1 (en) 2018-09-12
US10828273B2 (en) 2020-11-10
MX2016012203A (es) 2017-01-19
US9486428B2 (en) 2016-11-08
NL301338I2 (nl) 2025-09-11
ZA201606043B (en) 2018-05-30

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