KR101995894B1 - Detection lens of intraocular pressure, detection apparatus and method using the same - Google Patents
Detection lens of intraocular pressure, detection apparatus and method using the same Download PDFInfo
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- KR101995894B1 KR101995894B1 KR1020170062386A KR20170062386A KR101995894B1 KR 101995894 B1 KR101995894 B1 KR 101995894B1 KR 1020170062386 A KR1020170062386 A KR 1020170062386A KR 20170062386 A KR20170062386 A KR 20170062386A KR 101995894 B1 KR101995894 B1 KR 101995894B1
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- pattern
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
- A61B3/145—Arrangements specially adapted for eye photography by video means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
Abstract
The present invention relates to a lens for intraocular pressure sensing, an intraocular pressure sensing device, and a method for sensing an intraocular pressure using the same, the method comprising: preparing a first image including a first pattern of lenses worn on an eyeball; A second image preparation step of preparing a second image including a second pattern as a first reference; A third image generation step of merging the first image and the second image to generate a third image including a moiré pattern; And calculating an intraocular pressure by analyzing the third image.
Description
The present invention relates to a lens for intraocular pressure sensing, an intraocular pressure sensing device, and a method for sensing an intraocular pressure using the same, more particularly, The present invention relates to an intraocular pressure (IOP) detection system and a method of measuring intraocular pressure.
In general, intraocular pressure is an important factor in diagnosing glaucoma, but the method of measuring intraocular pressure in general screenings is a one-time measure of intraocular pressure. However, when the intraocular pressure is high, the intraocular pressure fluctuates greatly depending on the time of measurement. Therefore, it is troublesome for the patient to undergo remeasurement or to monitor the fluctuation of the intraocular pressure by hospitalization in case of serious case. Therefore, it is necessary to continuously measure the intraocular pressure while monitoring it.
A method of measuring intraocular pressure using a contact lens for noninvasive continuous monitoring of intraocular pressure has been proposed. However, there is a method of inserting a sensor into a contact lens. However, since the reader is relatively large, the patient has difficulty in daily life.
In recent years, a method of measuring intraocular pressure using a moire pattern has been proposed. In order to measure the intraocular pressure, a moire pattern is formed by overlapping two lenses to form a pattern image. However, when two lens layers are overlapped, there is a problem that the sensing ability is lowered due to the friction or the like generated between the two layers, and it is difficult to manufacture a lens, and a thick lens causes a foreign body feeling, which is inconvenient for a patient.
In order to overcome this problem, the first moire pattern is formed on the contact lens and the second moire pattern is formed on the other physical layer. However, it is not easy to always measure the actual moire pattern with the same angle, The distortion of the pattern due to the photographing angle largely occurs as the lens and the external pattern are distant from each other, and the image of the moire pattern varies depending on the angle and the distance between the two layers.
In order to solve the above problems, it is an object of the present invention to eliminate a method of physically forming a secondary moire pattern by using two lenses or to examine an external physical pattern and to create a virtual secondary moire pattern by software So that the moire pattern is virtually generated by using the first moire pattern to measure the intraocular pressure. However, these problems are exemplary and do not limit the scope of the present invention.
According to one aspect of the present invention, a method for detecting an intraocular pressure is provided. The method comprising: a first image preparation step of preparing a first image including a first pattern of lenses worn on an eyeball; A second image preparation step of preparing a second image including a second pattern that is a software-generated virtual first reference; A third image generation step of merging the first image and the second image to generate a third image including a moiré pattern; And calculating an intraocular pressure by analyzing the third image.
In the intraocular pressure sensing method, the first image preparation step may include preparing a lens having an alignment mark and the first pattern formed thereon; And a photographing step of photographing the first pattern formed on the lens by being worn on the eyeball.
In the intraocular pressure sensing method, the third image generation step may include: an alignment step of aligning the first pattern and the second pattern using an alignment mark formed on the lens; A merging step of merging the first pattern and the second pattern so as to form a third pattern; And a third image acquiring step of acquiring a shape change of the moire pattern of the third pattern to generate a third image.
In the intraocular pressure sensing method, after the alignment step, a filtering step of correcting the first pattern using the alignment mark to compensate for a tilt or a perspective of the first pattern may be performed.
In the intraocular pressure sensing method, the intraocular pressure calculating step may include calculating the intraocular pressure of the corresponding portion using a cycle in which the pattern is changed in the third pattern in which the first pattern changed by the intraocular pressure is overlapped with the second pattern .
In the intraocular pressure sensing method, the first pattern may be formed in a circular pattern having the same period.
A fourth image preparation step of preparing a fourth image including a fourth pattern as a second reference in the intraocular pressure sensing method; A fifth image generation step of merging the first image and the fourth image to generate a fifth image including a moiré pattern; And comparing and analyzing the third image and the fifth image to calculate the intraocular pressure.
In the intraocular pressure sensing method, the second pattern may be formed in a circular pattern having the same period, and the fourth pattern may be formed in a linear pattern having the same period.
According to one aspect of the present invention, an intraocular pressure sensing device is provided. A first image acquiring device for acquiring a first image including a first pattern of a lens to be worn on an eyeball; A second image input device for inputting a second image including a second pattern as a first reference; A third image generating device for generating a third pattern by merging the first pattern captured by the first image capturing device and the second pattern input from the second image capturing device; And an intraocular pressure calculation device for analyzing the third pattern to calculate an intraocular pressure.
In the intraocular pressure sensing device, the first image acquiring device may be a camera capable of photographing the lens having the first pattern formed thereon.
In the intraocular pressure sensing device, the third image generation device may include: an alignment unit that aligns the first pattern and the second pattern using an alignment mark formed on the lens; A merging unit for merging the first pattern and the second pattern so as to form a third pattern; And a third image acquiring unit for acquiring a shape change of the moiré pattern of the third pattern to generate a third image.
According to one embodiment of the present invention as described above, the lens for intraocular pressure sensing, the intraocular pressure sensing device, and the intraocular pressure sensing method using the same have no foreign object feeling like a general lens, Therefore, it is relatively easy to manufacture a lens by inserting a sensor into a contact lens, and the measurement method is relatively simple.
Thus, it is possible to perform measurement by inserting the lens without the user's feeling of discomfort, precise and effective measurement of the intraocular pressure, and alignment can be compensated by image processing within a certain angle, It is possible to provide an intraocular pressure detecting lens, an intraocular pressure sensing device, and an intraocular pressure sensing method using the same, which are easier to manufacture and manufacture than the intraocular pressure measuring device and the intraocular pressure measuring lens of the present invention. Of course, the scope of the present invention is not limited by these effects.
1 is a flowchart illustrating an intraocular pressure sensing method according to an embodiment of the present invention.
2 is a flowchart illustrating an intraocular pressure sensing method according to another embodiment of the present invention.
3 is a flowchart illustrating an intraocular pressure sensing method according to another embodiment of the present invention.
4 is a top view illustrating an eye-pressure-sensitive lens according to an embodiment of the present invention.
5 is a conceptual diagram schematically showing an intraocular pressure sensing device according to an embodiment of the present invention.
FIG. 6 is a block diagram illustrating an intraocular pressure sensing apparatus according to an embodiment of the present invention. Referring to FIG.
7 is a view illustrating a third image generating step of the intraocular pressure sensing method of FIG.
FIG. 8 is a diagram illustrating a third image generation step and a fifth image generation step of the intraocular pressure sensing method of FIG. 3;
9 is an experimental example showing differences in images according to photographing angles of the intraocular pressure sensing method.
10 is an experimental example showing the difference in the image of the circular pattern for each eye pressure in the intraocular pressure sensing method.
11 is an experimental example showing the difference in the vertical pattern image for each eye pressure of the intraocular pressure sensing method.
12 is an experimental example showing the difference between the external moire pattern and the virtual moire pattern image for each eye pressure of the intraocular pressure sensing method.
Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. It should be understood, however, that the invention is not limited to the disclosed embodiments, but may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, Is provided to fully inform the user. Also, for convenience of explanation, the components may be exaggerated or reduced in size.
4 is a top view illustrating an eye-pressure-sensitive lens according to an embodiment of the present invention.
As shown in FIG. 4, it is possible to calculate the intraocular pressure by comparing and analyzing the
More specifically, the
The
The
Here, moiré is also called interference pattern, wave pattern, and lattice pattern, and refers to a stripe that is created visually by the difference of these periods when the repeatedly repeated patterns are repeatedly combined.
In addition, the moire pattern technique is characterized by a lattice called a model lattice characterized by the deformation state of the surface. That is, when the reference pattern is projected on an object to be measured, the deformed pattern is generated according to the surface shape of the object, and the reference pattern and the deformed pattern interfere with each other, And extracts shape image information of the image.
FIG. 5 is a conceptual diagram schematically showing an intraocular pressure sensing device according to an embodiment of the present invention, and FIG. 6 is a configuration diagram illustrating an intraocular pressure sensing device according to an embodiment of the present invention.
5 and 6, the intraocular pressure sensing apparatus includes a first image acquiring device 20 (a second image acquiring device) for photographing a
The first
Then, the second
Thus, it is possible to measure without inserting the lens without inserting the lens. The lens can be manufactured without inserting the sensor into the conventional contact lens, and the lens for easy detection and production of the lens can be easily and easily manufactured. A detection method can be provided.
The third
More specifically, for example, in the
FIG. 1 is a flowchart showing an intraocular pressure sensing method according to an embodiment of the present invention, FIG. 7 is a diagram illustrating a third image generating step of the intraocular pressure sensing method of FIG. 1, Fig. 2 is a flowchart showing the method of detecting the intraocular pressure.
1, a method for detecting an intraocular pressure according to an exemplary embodiment of the present invention includes a first image preparation step S10, a second image preparation step S20, a third image generation step S30 And an intraocular pressure calculating step S40.
More specifically, for example, as shown in FIGS. 1 and 7, a first image preparation step of preparing a
2, the first image preparation step S10 includes a lens preparation step S11 for preparing a
At this time, the
As shown in FIGS. 1 and 7, the second image preparation step S20 includes preparing a
2 and 7, in the third image generation step S30, the first pattern P1 and the second pattern P2 are formed using the
More specifically, for example, as shown in Figs. 1 and 7, after alignment using the
At this time, the first pattern P1 and the second pattern P2 may be formed in a circular pattern having the same period, but the present invention is not limited thereto.
The intraocular pressure calculating step S40 is a step of calculating the intraocular pressure of the corresponding portion using a period in which the pattern is changed within the third pattern P3 in which the second pattern P2 and the first pattern P1 changed by the intraocular pressure are overlapped, Can be calculated.
FIG. 3 is a flowchart illustrating an intraocular pressure sensing method according to another embodiment of the present invention, and FIG. 8 illustrates a third image generation step and a fifth image generation step of the intraocular pressure sensing method of FIG.
3, the intraocular pressure sensing method according to an exemplary embodiment of the present invention includes a first image preparation step S10, a second image preparation step S20, a third image generation step S30, A fourth image preparation step S50, a fifth image generation step S60, and a comparison calculation step S70.
Here, the first image preparation step (S10), the second image preparation step (S20), and the third image generation step (S30) are described in detail above, and a detailed description is omitted.
As shown in FIGS. 3 and 8, the fourth image preparation step S50 is a step of preparing a
3 and 8, the fifth image generation step S60 may include merging the
More specifically, for example, as shown in FIGS. 3 and 8, after the alignment using the
At this time, the second patterns P2 may be formed in a circular pattern having the same period, and the fourth patterns P4 may be formed in a linear pattern having the same period, but the present invention is not limited thereto.
The comparative calculation step S70 is a step of comparing the
Hereinafter, an experimental example to which the technical idea described above is applied will be described in order to facilitate understanding of the present invention. It should be understood, however, that the following examples are for the purpose of promoting understanding of the present invention and are not intended to limit the scope of the present invention.
[Experimental Example]
9 is an experimental example showing differences in images according to photographing angles of the intraocular pressure sensing method.
Experiment is an experiment to verify alignment when using virtual moire pattern. Also, the first moiré pattern may be the
Here, FIG. 9 shows a case of using a virtual second order moire pattern and a case of using an external second order moire pattern, and experimenting a moire pattern depending on the photographing angle. In the case of using the virtual second moiré pattern, the photographing was performed with the cameras tilted at 0 degree, 10 degrees, 20 degrees, and 30 degrees from the reference angles in the case where the image processing was not performed or was performed.
As shown in FIG. 9, the pattern change according to the angle was the largest when the image was not compensated using the virtual second order moire pattern. The second largest change was in the case where the external second order moire pattern was used, The result is that the captured image is aligned with the alignment mark in the center and the difference according to the angle is changed a second time.
Also, although the pattern difference was not large at an angle change of about 10 degrees, it was confirmed that as the angle increased to 20 degrees and 30 degrees, the bright region greatly increased and the pattern difference increased.
In the case of using the virtual second moire pattern and image processing, it was not possible to confirm the pattern change at 10 degrees and 20 degrees, and the pattern was faint at 30 degrees or more, but in the other two cases The case of using the second moire pattern and the case of using the second moire pattern using the second moire pattern) is very small.
It is shown that only a lens of a first moire pattern is used and a virtual second moire pattern is used to obtain a result similar to or better than that using an outer second moire pattern as in the experimental example.
FIG. 10 is an experimental example showing the difference in the image of the circular pattern according to the pressure of the eye of the intraocular pressure sensing method, and FIG. 11 is an experimental example showing the difference of the vertical pattern image according to the eye pressure of the intraocular pressure sensing method.
Figs. 10 and 11 show changes in the shape of the lens when a pressure change is applied by using a circular and linear pattern shown in Fig. 8 in a virtual second moire pattern, and after aligning using the alignment mark and compensating for perspective, And shows the result of observing the raw moiré pattern by overlapping the car moire pattern.
Specifically, FIG. 10 shows a pattern shape according to a pressure change of 0, 10, 15, 20, 25 mmHg when a circular virtual second moire pattern is used, and FIG. 11 shows a virtual
As shown in FIGS. 10 and 11, although the shape of the pattern changes in the case of the circular pattern, it is difficult to understand it, and it is difficult to analyze and quantify it. However, when the vertical virtual pattern is used, It will be easy to quantify.
12 is an experimental example showing the difference between the external moire pattern and the virtual moire pattern image according to the eye pressure of the eye pressure method of the intraocular pressure sensing method and shows the result of the pattern change when the actual external second moire pattern and the virtual second moire pattern are used I compared the images of the two cases.
As shown in FIG. 12, when an actual external second moire pattern is used, a pattern change occurs mainly at both ends similar to the case where a virtual second moire pattern is used. As the pressure is changed, the oblique pattern becomes larger The trend of the image change was the same.
These results show that even using the virtual second moire pattern, results similar to those obtained by using the external second moire pattern can be obtained. Accordingly, the pattern variation is quantified using the virtual second moire pattern.
At this time, after obtaining the histogram of the orientation after extracting the edge of the image obtained using the virtual second moire pattern and obtaining the value for the specific angle, the values according to the pressure can be quantified, , And similar results were obtained by applying different angles.
Thus, the alignment can be compensated by the image processing within a certain angle, so that the processing can be performed irrespective of the shooting distance.
While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the invention. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.
1: Body
2: Alignment mark
3: moire pattern layer
10: Lens
20: First image acquisition device
30: second image input device
40: Third image generating device
41:
42:
43:
100: First image
200: Second video
300: Third video
400: fourth image
500: fifth image
P1: 1st pattern
P2: second pattern
P3: Third pattern
P4: Fourth pattern
P5:
Claims (11)
A second image preparation step of preparing a second image including a second pattern that is a software-generated virtual first reference;
A third image generation step of merging the first image and the second image to generate a third image including a moiré pattern; And
And an intraocular pressure calculating step of analyzing the third image to calculate an intraocular pressure,
Wherein the third image generation step comprises:
An alignment step of aligning the first pattern and the second pattern using an alignment mark formed on the lens;
A merging step of merging the first pattern and the second pattern so as to form a third pattern; And
And a third image acquiring step of acquiring a shape change of the moire pattern of the third pattern to generate a third image,
After the aligning step,
A filtering step of correcting the first pattern using the alignment mark to compensate for a slope or a perspective of the first pattern;
Further comprising the steps of:
Wherein the first image preparation step comprises:
A lens preparing step of preparing an alignment mark and the lens on which the first pattern is formed; And
A photographing step of photographing the first pattern formed on the lens by being worn on the eyeball;
/ RTI >
The intraocular pressure-
Wherein the intraocular pressure of the corresponding portion is calculated using a period in which the pattern is changed in the third pattern in which the second pattern and the first pattern changed by the intraocular pressure are overlapped.
Wherein the first pattern is formed in a circular pattern having the same period.
A fourth image preparation step of preparing a fourth image including a fourth pattern as a second reference;
A fifth image generation step of merging the first image and the fourth image to generate a fifth image including a moiré pattern; And
Comparing the third image and the fifth image to calculate an intraocular pressure;
Further comprising the steps of:
The second pattern is formed in a circular pattern having the same period,
Wherein the fourth pattern is formed in a linear pattern having the same period.
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KR1020170062386A KR101995894B1 (en) | 2017-05-19 | 2017-05-19 | Detection lens of intraocular pressure, detection apparatus and method using the same |
PCT/KR2018/005147 WO2018212489A1 (en) | 2017-05-19 | 2018-05-03 | Lens for sensing intraocular pressure, intraocular pressure sensing device, and intraocular pressure sensing method using same |
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KR1020170062386A KR101995894B1 (en) | 2017-05-19 | 2017-05-19 | Detection lens of intraocular pressure, detection apparatus and method using the same |
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WO2024019245A1 (en) * | 2022-07-20 | 2024-01-25 | 연세대학교 산학협력단 | Intraocular lens using moiré interference hydrogel |
Citations (1)
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US20140163351A1 (en) * | 2012-12-12 | 2014-06-12 | National Taiwan University | System and method for monitoring change of intraocular pressure and contact lens for sensing change of intraocular pressure |
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CN101861119B (en) * | 2007-10-19 | 2013-03-13 | 森思迈德股份公司 | Intraocular pressure monitoring device |
US20150148648A1 (en) * | 2013-11-22 | 2015-05-28 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lens with intraocular pressure monitoring system |
EP3017751B1 (en) * | 2014-11-06 | 2020-10-21 | Ophtimalia | Physiological parameter monitoring device |
WO2016173554A1 (en) * | 2015-04-30 | 2016-11-03 | Lon Wang | Contact lens without moire pattern in center, method for analyzing change of moire pattern thereof, and system for monitoring an intraocular pressure variation |
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US20140163351A1 (en) * | 2012-12-12 | 2014-06-12 | National Taiwan University | System and method for monitoring change of intraocular pressure and contact lens for sensing change of intraocular pressure |
Cited By (1)
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WO2024019245A1 (en) * | 2022-07-20 | 2024-01-25 | 연세대학교 산학협력단 | Intraocular lens using moiré interference hydrogel |
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