KR101989247B1 - Manufacturing method of hydrogel contact lens using blowing agent - Google Patents
Manufacturing method of hydrogel contact lens using blowing agent Download PDFInfo
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- B29D11/00—Producing optical elements, e.g. lenses or prisms
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- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
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Abstract
Description
본발명은 발포제를 이용한 하이드로겔 콘택트렌즈 제조방법에 관한 것으로, 보다 상세하게는 높은 광투과율은 물론 콘택트렌즈의 함수율 증가, 산소투과율이 증가 하며, 또한 접촉각이 감소하여 습윤성이 향상되며, 단백질흡착이 감소하는 발포제를 이용한 하이드로겔 콘택트렌즈 제조방법에 관한 것이다.The present invention relates to a method for manufacturing a hydrogel contact lens using a blowing agent, and more particularly, to a method for manufacturing a hydrogel contact lens using a blowing agent, And to a method for manufacturing a hydrogel contact lens using the blowing agent.
일반적으로 다공성 하이드로겔은 친수성 폴리머의 3차원 네트워크 구조로 이루어져 있어 많은 양의 물을 빠른 시간 안에 흡수할 수 있는 성질을 가지고 있다.Generally, the porous hydrogel has a three-dimensional network structure of a hydrophilic polymer, so that it can absorb a large amount of water in a short time.
일반 하이드로겔의 경우 확산현상에 의해 물을 흡수하기 때문에 건조되어있는 상태에서 완전히 수화되어지는데 까지 짧게는 몇 분에서 길게는 몇 일에 걸쳐 수화가 되지만, 초다공성 하이드로겔은 모세관 현상에 의해 물을 흡수하기 때문에 크기에 상관없이 몇 분 내에 완전한 수화가 가능하다.In the case of ordinary hydrogels, water is absorbed by the diffusion phenomenon. Therefore, hydration takes a few minutes to several days until it is completely hydrated in a dry state. However, in the case of a hydrogel, Because of its absorption, full hydration is possible within minutes, regardless of size.
다공성 하이드로겔을 제조하는 방법으로는 Porosigen technique, Salt leaching method, Hydrogel 동결건조, Phase separation technique, Gas foaming technique등이 있다.Porous hydrogel can be prepared by Porosigen technique, Salt leaching method, Hydrogel lyophilization, Phase separation technique, Gas foaming technique.
다공성 하이드로겔에 사용되고 있는 발포제는 Sodium bicarbonate, Sodium carbonate, Potassium carbonate, Potassium bicarbonate, Ammonium carbonate, Ammonium bicarbonate, magnessium carboante 등이 있다.Sodium bicarbonate, sodium carbonate, potassium carbonate, potassium bicarbonate, ammonium carbonate, ammonium bicarbonate, and magnessium carboante are examples of foaming agents used in porous hydrogels.
한편, 종래 특허문헌으로는 등록특허공보 등록번호 10-1545757호에는 건조한 하이드로겔 콘택트 렌즈를 수화 용액에서 수화하는 단계를 포함하고, 여기에서 상기 수화 용액은 은 나노입자, 및 윤활제 또는 습윤제를 포함하며, 상기 은 나노입자, 및 윤활제 또는 습윤제는 수화 용액 중 상기 건조한 하이드로겔 콘택트 렌즈의 수화 도중 상기 하이드로겔 콘택트 렌즈 상에 흡착되고/되거나 그 안에 포획되며, 상기 은 나노입자는 폴리음이온성 물질, 폴리양이온성 물질, 폴리비닐 알코올 (PVA), 폴리비닐피롤리돈 (PVP), N-비닐피롤리돈과 1종 이상의 비닐계 단량체의 공중합체, 및 이들의 조합으로 이루어진 군에서 선택되는 1종 이상의 안정화제의 존재 하에 제조되는 것을 특징으로 하는, 하이드로겔 콘택트 렌즈의 제조 방법이 공개되어 있다.On the other hand, in the conventional patent document, Registration No. 10-1545757 includes a step of hydrating a dry hydrogel contact lens in a hydration solution, wherein the hydration solution comprises silver nanoparticles and a lubricant or wetting agent Wherein the silver nanoparticles and the lubricant or wetting agent are adsorbed on and / or entrapped on the hydrogel contact lens during hydration of the dry hydrogel contact lens in a hydration solution, the silver nanoparticles being a polyanionic material, poly (PVA), polyvinylpyrrolidone (PVP), a copolymer of N-vinylpyrrolidone and one or more vinyl monomers, and combinations thereof. Wherein the hydrogel contact lens is produced in the presence of a stabilizer.
또한, 등록특허공보 등록번호 10-0703583호에는 실리콘계 마크로머를 그룹 전이 중합법(Group Transfer Polymerization)으로 제조하는 단계 및 당해 마크로머를 Si7-9 모노메타크릴옥시 말단화 폴리디메틸실록산, Si7-9 모노메타크릴옥시 말단화 폴리디메틸실록산 이외의 폴리디메틸실록산 및 친수성 단량체를 포함하는 중합성 혼합물과 반응시키는 단계를 포함하는, 중합체의 제조방법이 공개 되어 있다.In addition, Patent Registration No. 10-0703583 discloses a process for producing a silicon-based macromer by Group Transfer Polymerization and a process for producing the macromolecule by reacting Si7-9 monomethacryloxy-terminated polydimethylsiloxane, Si7-9 With a polymerizable mixture comprising a polydimethylsiloxane other than monomethacryloxy-terminated polydimethylsiloxane and a hydrophilic monomer. ≪ Desc / Clms Page number 3 >
그러나 상기 종래기술들은 광투과율, 함수율, 산소투과율이 감소하며, 접촉각이 크서 습윤성이 나빠지며, 단백질흡착이 많은 문제점이 여전히 있다.However, the above conventional techniques have a problem in that the light transmittance, water content, and oxygen permeability are decreased, the contact angle is large and wettability is deteriorated, and protein adsorption is still many.
따라서 본 발명은 상기와 같은 문제점을 해결하고자 안출된 것으로, 본 발명은 발포제를 이용한 하이드로겔 콘택트렌즈 제조에 관한 것으로, 기존의 하이드로겔 콘택트렌즈가 가지는 산소투과율 저하 등의 단점과 실리콘하이드로겔이 가지는 함수율 저하, 습윤성 저하 등의 단점을 보완하여 기능성을 향상시키는데 목적이 있다.Accordingly, the present invention has been made to solve the above problems, and it is an object of the present invention to provide a hydrogel contact lens manufacturing method using a foaming agent, and it is an object of the present invention to provide a hydrogel contact lens, Lowering of water content, lowering of wettability, and the like.
본발명은 발포제를 이용한 하이드로겔 콘택트렌즈 제조방법에 관한 것으로, 하이드로겔 콘택트렌즈를 제조하기 위한 기본 시료에 발포제를 첨가하여 다공성 하이드로겔 콘택트렌즈를 제조하는 것을 특징으로 한다.The present invention relates to a method of manufacturing a hydrogel contact lens using a blowing agent, and a method of manufacturing a porous hydrogel contact lens by adding a foaming agent to a basic sample for producing a hydrogel contact lens.
따라서 본발명은 발포제를 사용하여 다공성 하이드로겔 콘택트렌즈를 제조하여, 상기 발포제에 의한 기공생성으로 인해 높은 광투과율은 물론 콘택트렌즈의 함수율 증가, 산소투과율이 증가 하며, 또한 접촉각이 감소하여 습윤성이 향상되며, 단백질흡착이 감소하는 현저한 효과가 있다.Accordingly, the present invention provides a porous hydrogel contact lens using a blowing agent, and it is possible to increase the moisture transmittance and the water content of the contact lens as well as the high light transmittance due to the pore formation by the blowing agent, And there is a remarkable effect that the protein adsorption is reduced.
도 1은 본 발명인 발포제를 이용한 하이드로겔 콘택트렌즈의 함수율을 보여주는 그래프
도 2는 본 발명인 발포제를 이용한 하이드로겔 콘택트렌즈의 산소투과율을 보여주는 그래프
도 3은 본 발명인 발포제를 이용한 하이드로겔 콘택트렌즈의 습윤성을 보여주는 그래프1 is a graph showing the water content of a hydrogel contact lens using the foaming agent of the present invention
2 is a graph showing the oxygen permeability of a hydrogel contact lens using the blowing agent of the present invention
3 is a graph showing the wettability of the hydrogel contact lens using the blowing agent of the present invention
본발명은 발포제를 이용한 하이드로겔 콘택트렌즈 제조방법에 관한 것으로, 하이드로겔 콘택트렌즈를 제조하기 위한 기본 시료에 발포제를 첨가하여 다공성 하이드로겔 콘택트렌즈를 제조하는 것을 특징으로 한다.The present invention relates to a method of manufacturing a hydrogel contact lens using a blowing agent, and a method of manufacturing a porous hydrogel contact lens by adding a foaming agent to a basic sample for producing a hydrogel contact lens.
또한, 상기 기본 시료는 HEMA, MAA, Styrene, EGDMA, AIBN 을 혼합한 것임을 특징으로 한다.Also, the basic sample is a mixture of HEMA, MAA, styrene, EGDMA, and AIBN.
본발명을 첨부도면에 의해 상세히 설명하면 다음과 같다. 도 1은 본 발명인 발포제를 이용한 하이드로겔 콘택트렌즈의 함수율을 보여주는 그래프, 도 2는 본 발명인 발포제를 이용한 하이드로겔 콘택트렌즈의 산소투과율을 보여주는 그래프, 도 3은 본 발명인 발포제를 이용한 하이드로겔 콘택트렌즈의 습윤성을 보여주는 그래프이다.The present invention will be described in detail with reference to the accompanying drawings. FIG. 1 is a graph showing the water content of a hydrogel contact lens using the blowing agent of the present invention. FIG. 2 is a graph showing the oxygen permeability of the hydrogel contact lens using the blowing agent of the present invention, and FIG. 3 is a graph showing the oxygen permeability of the hydrogel contact lens using the blowing agent of the present invention. This is a graph showing wettability.
다공성 하이드로겔을 제조하는 방법으로는 Porosigen technique, Salt leaching method, Hydrogel 동결건조, Phase separation technique, Gas foaming technique등이 있다. Porous hydrogel can be prepared by Porosigen technique, Salt leaching method, Hydrogel lyophilization, Phase separation technique, Gas foaming technique.
본 발명은 초다공성 하이드로겔을 제조하기 위하여 Gas foaming 방식을 사용하였고, 사용된 발포제로는 Sodium carbonate, Sodium bicarbonate, Potassium carbonate, Potassium bicarbonate, ammonium carbonate, ammonium bicarbonate이다.In the present invention, a gas foaming method is used to produce a microporous hydrogel. Sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, ammonium carbonate, and ammonium bicarbonate are used as the foaming agent.
중탄산나트륨은 열반응에 의해 탄산나트륨, 이산화탄소, 물 등으로 분해되고, 탄산나트륨은 산화나트륨과 이산화탄소가 생성된다. 이와 같이 분해된 발포생성물들은 원재료와 혼합되어 초다공성 하이드로겔이 형성된다. Sodium bicarbonate is decomposed into sodium carbonate, carbon dioxide, water and the like by thermal reaction, and sodium carbonate produces sodium oxide and carbon dioxide. The decomposed foam products are mixed with the raw material to form a porous hydrogel.
2NaHCO3 ->Na2CO3 + CO2 + H2O2NaHCO 3 -> Na 2 CO 3 + CO 2 + H 2 O
Na2CO3 -> Na2O + CO2 Na 2 CO 3 -> Na 2 O + CO 2
실시 예:Example:
본 발명에 사용되는 발포제가 첨가된 하이드로겔 콘택트렌즈 재질의 필름 제작을 위해 사용된 모노머와 비율은 표1에 나타내었다.Table 1 shows the ratios of the monomers used for producing the film of the hydrogel contact lens material to which the foaming agent is added in the present invention.
기본 시료(Ref.)인 하이드로겔 콘택트렌즈 원료는 HEMA, MAA, Styrene, EGDMA, AIBN으로 만들었다. 상기 기본 시료에 발포제를 첨가한다. 발포제를 첨가한 하이드로겔 필름을 만들기 위해 발포제 위에서 제시한 다양한 발포제를 3차 증류수에 녹여 수용액으로 만들었다. 발포제 함량은 중량비로 전체 하이드로겔 콘택트렌즈 원료의 0.1중량부에서 20중량부까지 가능하나 콘택트렌즈로서 가장 물리화학적 특성이 좋은 것은 1중량부 ~ 5중량부 범위이다. The raw material of the hydrogel contact lens which is the basic sample (Ref.) Was made of HEMA, MAA, Styrene, EGDMA, AIBN. A foaming agent is added to the basic sample. To make a hydrogel film with a foaming agent added, various foaming agents as described above were dissolved in tertiary distilled water to prepare an aqueous solution. The foaming agent content may range from 0.1 part by weight to 20 parts by weight of the entire hydrogel contact lens raw material in a weight ratio, but it is in the range of 1 part by weight to 5 parts by weight when the contact lens has the best physical and chemical properties.
발포제 함량이 중량비로 전체 하이드로겔 콘택트렌즈 원료의 0.1중량부 미만이 첨가되면 본발명의 추구하는 효과인 광투과율, 함수율, 산소투과율, 습윤성에 대한 효과가 달성되기 어렵다. 20 중량부를 초과하면 투명성이 나빠진다. When the amount of the foaming agent is less than 0.1 part by weight of the entire hydrogel contact lens raw material in a weight ratio, the effect on the light transmittance, water content, oxygen permeability, and wettability of the present invention is difficult to achieve. If it exceeds 20 parts by weight, transparency deteriorates.
곧 본발명의 혼합비는 중량비로 HEMA 90중량부에 대하여, MAA 1 ~ 20중량부, Styrene 1 ~ 20 중량부, EGDMA 0.1 ~ 3중량부, AIBN 0.05 ~ 1중량부, 발포제 0.1 ~ 20 중량부의 비율로 만들어 진다.The mixing ratio of the present invention is 1 to 20 parts by weight of MAA, 1 to 20 parts by weight of styrene, 0.1 to 3 parts by weight of EGDMA, 0.05 to 1 part by weight of AIBN and 0.1 to 20 parts by weight of blowing agent, based on 90 parts by weight of HEMA .
표 1에 나타낸 비율로 시약을 배합하여 교반기로 1시간 혼합한 후 1시간동안 안정화를 시켰다. 안정화된 시약을 제작된 몰드에 주입 후 열중합기를 이용하여 100℃에서 1시간동안 열 중합하였다.The reagents were mixed at the ratios shown in Table 1, mixed for 1 hour with a stirrer, and stabilized for 1 hour. The stabilized reagent was injected into the mold and thermally polymerized at 100 ° C for 1 hour using a thermocouple.
S1S1
S2
S3
S4S4
(2) 물리적 특성 결과:(2) Physical properties Result:
a)함수율a) Moisture content
- 함수율을 측정하여 도 1에 제시하였으며 기준에 비해 발포제가 첨가됨으로써 함수율이 크게 증가하였음을 확인하였다.- The water content was measured and shown in FIG. 1, and it was confirmed that the water content was greatly increased by adding the foaming agent to the standard.
b) 산소투과도b) Oxygen permeability
- ISO 18369-4:2006에서 제시한 Polarographic 방법으로 실시하였으며 두께측정기 Mitutoyo사의 VL-50으로 중심 두께를 측정하여 사용하였다.- Polarographic method as specified in ISO 18369-4: 2006 was used and the center thickness was measured with VL-50 of Mitutoyo thickness gauge.
발포제가 포함된 콘택트렌즈에서 산소투과도가 현저히 높아짐을 확인하였다. 도 2참조It was confirmed that the oxygen permeability was significantly increased in the contact lens containing the blowing agent. 2
c)접촉각c) Contact angle
접촉각 측정은 Sessile drop 방법으로 접촉각 측정을 하였으며, 본 발명 시료의 접촉각이 매우 감소하여 습윤성이 크게 향상됨을 확인하였다. 도3 참조The contact angle was measured by the contact drop method using the Sessile drop method, and it was confirmed that the contact angle of the sample of the present invention was greatly reduced and the wettability was greatly improved. 3
따라서 본발명은 발포제를 사용하여 다공성 하이드로겔 콘택트렌즈를 제조하므로, 상기 발포제에 의한 기공생성으로 인해 높은 광투과율은 물론 콘택트렌즈의 함수율 증가, 산소투과율이 증가 하며, 또한 접촉각이 감소하여 습윤성이 향상되며, 단백질흡착이 감소하는 현저한 효과가 있다.Therefore, since the porous hydrogel contact lens is manufactured using the blowing agent, the pore generation by the blowing agent increases the water permeability, water content of the contact lens, oxygen transmittance, contact angle, and wettability And there is a remarkable effect that the protein adsorption is reduced.
Claims (2)
상기 기본 시료는 HEMA, MAA, Styrene, EGDMA, AIBN 을 혼합한 것이며,
상기 발포제와의 혼합비는 HEMA 90중량부에 대하여, MAA 1 ~ 20중량부, Styrene 1 ~ 20 중량부, EGDMA 0.1 ~ 3중량부, AIBN 0.05 ~ 1중량부, 발포제 0.1 ~ 20 중량부의 비율로 만들어지는 것이며,
상기 기본 시료와 발포제 혼합물은 배합하여 교반기로 1시간 혼합한 후 1시간동안 안정화를 시키고, 안정화된 시약을 제작된 몰드에 주입 후 열중합기를 이용하여 100℃에서 1시간동안 열 중합하는 것을 특징으로 하는 발포제를 이용한 하이드로겔 콘택트렌즈 제조방법
A method for manufacturing a hydrogel contact lens using a foaming agent for producing a porous hydrogel contact lens by adding a foaming agent to a basic sample for producing a hydrogel contact lens,
The basic sample is a mixture of HEMA, MAA, Styrene, EGDMA and AIBN,
The blending ratio of the blowing agent with the foaming agent is 1 to 20 parts by weight of MAA, 1 to 20 parts by weight of styrene, 0.1 to 3 parts by weight of EGDMA, 0.05 to 1 part by weight of AIBN and 0.1 to 20 parts by weight of a blowing agent based on 90 parts by weight of HEMA And,
The basic sample and the foaming agent mixture are mixed and stirred for 1 hour with an agitator, and stabilized for 1 hour. The stabilized reagent is injected into the mold and thermally polymerized at 100 ° C for 1 hour using a thermocouple Of manufacturing a hydrogel contact lens using a foaming agent
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| KR102232953B1 (en) * | 2020-01-29 | 2021-03-25 | 대구가톨릭대학교산학협력단 | Manufacturing method of porous silicon hydrogel contact lens containing agiate |
| KR102232954B1 (en) * | 2020-01-29 | 2021-03-25 | 대구가톨릭대학교산학협력단 | Manufacturing method of high wettablility and antimicrobial contact lens using carrageenan |
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| KR102232953B1 (en) * | 2020-01-29 | 2021-03-25 | 대구가톨릭대학교산학협력단 | Manufacturing method of porous silicon hydrogel contact lens containing agiate |
| KR102232954B1 (en) * | 2020-01-29 | 2021-03-25 | 대구가톨릭대학교산학협력단 | Manufacturing method of high wettablility and antimicrobial contact lens using carrageenan |
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