KR101901630B1 - Pharmaceutical composition for prevention or tretment of pruritus comprising leaf of sanjook, flower of marigold, root of chinese catbrier and root of curly dock, and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for preventing and treating pruritus and a manufacturing method thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing and treating pruritus comprising oil which contains Sasa borealis leaves, marigold flowers, smilax roots, and Rumex patientia roots. The pharmaceutical composition manufactured by the method of the present invention is a very useful invention in the pharmaceutical industry, because the composition can effectively alleviate the symptoms of itching caused heat rash, athlete′s foot, dry skin, bug bites from mosquito or other insects, and the itchiness from sequelae of shingles.

Description

FIELD OF THE INVENTION The present invention relates to a pharmaceutical composition for prevention or treatment of pruritus, and a method of producing the same. CATBRIER AND ROOT OF CURLY DOCK, AND MANUFACTURING METHOD THEREOF}

The present invention relates to a pharmaceutical composition for preventing or treating itching and a method of preparing the same, and more particularly, to a pharmaceutical composition for prevention or treatment of itch, including oil containing a flower leaf, marigold flower, A pharmaceutical composition and a process for producing the same.

The skin of the human body is physically and chemically an indispensable body for maintaining the life from the outside world while maintaining the biochemical functions necessary for the metabolism of the whole body. Common skin diseases include atopic dermatitis, contact dermatitis, seborrheic dermatitis, urticaria, athlete's foot, rash, psoriasis, herpes simplex / shingles, dry skin, housekeeping eczema and acne.

Outside of such skin diseases, there are mechanical stimuli such as friction, compression and puncture that directly acts on the skin from the outside world, as well as animal, vegetable and mineral poison, other medicines, radiation, heat, cold or bacteria, , Viruses, and parasites of the skin. Examples of the endogenous agents include gastrointestinal disorders, liver diseases, kidney diseases, metabolic disorders, blood diseases, visceral tumors, endocrine disorders, and the like. Hereditary skin diseases, nevus, and maternal diseases are included in endogenous skin diseases because they are caused by genes.

Among skin diseases, in particular, atopic dermatitis is a typical skin disease that occurs in a person having atopic allergy. It is one of the chronic skin diseases called as fever, and is a recurrent chronic dermatitis accompanied by a severe leaning sensation. In recent decades, the prevalence of atopic dermatitis has been rising steadily due to the increase of air-mediated allergens caused by environmental pollution and the condition for forming dry skin. % Are known to suffer from this dermatitis. Atopic dermatitis is a chronic recurrent dermatitis that lasts until adulthood in infancy and childhood, and is a skin disease accompanied by extreme leaning, dry skin, erythema, edema and exudation.

According to a study of the prevalence of atopic dermatitis in Korea, the prevalence rate of atopic dermatitis was reported to be 28.22% in children, and other studies reported a subjective prevalence of adult atopic dermatitis of 3.09%. The main symptoms are itching and dryness of the skin, and it may be accompanied by other allergic diseases such as urticaria, asthma, allergic rhinitis and allergic conjunctivitis.

In addition, aging of cells is a physiological phenomenon, and the period of regeneration of skin cells, which is the basic unit constituting the skin, is not normally performed, becomes longer, and as a result, the skin loses its elasticity, It begins to wrinkle as it begins to wrinkle. Currently, we use surgery, ointment and vitamin C therapy to restore the skin caused by aging, but it is not enough to maintain our long-cherished tension and resilient skin.

Methods for ameliorating or treating such atopic skin diseases include, but are not limited to, methods for improving skin dryness symptoms, methods of using immunomodulators to inhibit the production of IgE, methods of using antibacterial and / , And a method of combining two or more of them is also known. In addition, although steroids are widely used for the treatment of skin diseases including atopic dermatitis and inflammatory dermatitis, steroid agents can manifest various side effects such as decreased immunity, skin thinning, atrophy and flushing, There are serious adverse effects such as steroid acne, steroidal skin (skin atrophy, capillary vasodilatation, purpura), steroid injection, dermatitis in situ, hair follicle, pigment desilyl, ancestor, .

There have been developed a skin aging prevention and skin remedy using natural substances for a few years, but there are cases in which they have a function as a skin modifying agent for the action of inhibiting the androgen, which is a male hormone, and the action of suppressing the increase of sebum secretion, It has not provided a practical effect as a therapeutic agent for skin. Recently, medical skin care has been developed for skin treatment not only in Korea, but also in USA, Europe and Japan, including medical treatment and skin care, Acne, spots, and freckles, but still many skin diseases are not overcome, is an important cause of degradation of quality of life.

In this connection, there have been known examples of extracting active ingredients of herbal medicines, which are known to have effects of skin improvement, moisturizing, wrinkle improvement and the like, as a skin remedy. For example, Korean Patent Laid-Open No. 10-2010-0101269 and Korean Patent No. 10-0962587 disclose a composition for improving skin using a wide variety of plant materials. However, both of them are technologies characterized by a fermentation method, It is not an excellent skin improvement effect of a single plant or a mixed extract of a specific plant. Korean Patent No. 10-0991399, Korean Patent No. 10-0999870 and Korean Patent No. 10-0987563 disclose compositions for improving atopic dermatitis including a wide variety of plant extracts.

However, most of these techniques only alleviate itching or inflammation, and thus the therapeutic effect is insignificant, so that the application is limited in practice. The above-mentioned methods for healing or improving atopic dermatitis are intended to alleviate or ameliorate one or more of the symptoms such as itching reduction or anti-inflammation, and serious side effects such as complex infection may occur. There are also cases. In addition, those containing various herbal medicines are mainly oral medicines or health supplements, which may be beneficial for relieving atopic dermatitis, but other side effects may occur. That is, when using various natural herbal materials, the methods of improving side effects may be different from each other, and the timing of improvement may be different, and the effect of preventing recurrence may be different. Accordingly, there is a need for a herbal composition which has excellent effects and is safe and free of skin irritation.

KR 10-0991399 B KR 10-2013-0077314 A

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and an object of the present invention is to provide a method for treating patients suffering from severe itching after bitten by a hot rash, athlete's foot, dry skin, mosquito or insect, The present invention provides a pharmaceutical composition which can effectively alleviate the itching symptom of < RTI ID = 0.0 > a < / RTI >

In order to solve the above-mentioned problems, the present invention provides a method for producing a honeycomb structure, comprising the steps of: (1) immersing a green leaf, a marigold flower, a green seaweed root and a Sorghum root in olive oil; (2) storing in a cow for 5 to 10 days; (3) heating at 60 to 70 DEG C for 1 to 3 hours; And (4) a step of cooling the mixture.

The itching is preferably caused by a rash, athlete's foot, dry skin, mosquito bites, insect bites or shingles sequelae.

In the step (1), 1 to 5 parts by weight of the green tea leaves, 5 to 20 parts by weight of the marigold flowers, 10 to 30 parts by weight of the green radish roots and 20 to 40 parts by weight of the green tea roots are immersed in 100 parts by weight of the olive oil desirable.

The present invention also provides a pharmaceutical composition for preventing or treating itch, which is obtained by the above-described production method.

The pharmaceutical composition prepared according to the production method of the present invention is an extremely useful invention in the pharmaceutical industry because it can effectively improve the symptoms of itch caused by afterglow of itch and biting in rash, athlete's foot, dry skin, mosquito or insect.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a process drawing showing a method for preparing a pharmaceutical composition for preventing or treating itch of the present invention.

Hereinafter, the present invention will be described in detail.

The inventors of the present invention have conducted studies to develop an effective material for relieving and improving skin itching caused by afterglow of herpes zoster or swelling of the skin such as fever, athlete's foot, dry skin, mosquito or insect, The present invention has been accomplished by confirming that the oil composition obtained by immersing the root of Cheongwisan and Sorghum root in olive oil and applying the oil composition obtained by a certain method to the itchy skin remarkably improves the itching.

Accordingly, the present invention relates to a method for the production of (1) a process for the production of (1) a process comprising the steps of: immersing a southern porridge, a marigold flower, a green seaweed root and a Sorghum root in olive oil; (2) storing in a cow for 5 to 10 days; (3) heating at 60 to 70 DEG C for 1 to 3 hours; And (4) a step of cooling the mixture.

The above step (1) is a step of mixing components of the oil composition which is a pharmaceutical composition for preventing or treating itch of the present invention. In the present invention, as a natural plant material, a useful oil soluble ingredient is extracted by immersing a leaf of Sanjuku, a flower of marigold, a root of a Korean green tea and a root of a Sorghum root in olive oil.

As a preferable example, each component used in the production of the oil composition, which is a pharmaceutical composition for preventing or treating itching according to the present invention, comprises 1 to 5 parts by weight of green tea leaf, 5 to 20 parts by weight of marigold flower 10 to 30 parts by weight of root, and 20 to 40 parts by weight of root.

In step (2), the oil composition mixed in step (1) is placed in, for example, a glass bottle and allowed to stand in a dark place for 5 to 10 days, preferably 7 days, so that the oil- .

The step (3) is a step of heating the oil composition placed in the dark in the step (2) in a weak fire, for example, heating the oil composition after putting the oil composition put in a cow in a fermenter.

As a preferred specific example, the oil composition which has been placed in a cow for about one week can be heated in a fire for about 2 hours after it is put in a fermenter.

Step (4) is a step of cooling the oil composition obtained from step (3) by leaving it at room temperature.

The oil composition, which is a pharmaceutical composition for preventing or treating itch of the present invention, can effectively prevent or ameliorate skin itching caused by sequelae, athlete's foot, dry skin, mosquito or insect, have.

Accordingly, the present invention provides a pharmaceutical composition for preventing or treating itch, which is obtained by the above-described production method.

The itching may be, but is not limited to, for example, rashes, athlete's foot, dry skin, mosquito bites, insect bites or itch caused by shingles sequelae.

The pharmaceutical composition of the present invention can be applied to the skin in the form of an oil. Such pharmaceutical compositions may further comprise carriers, excipients or diluents, and examples of suitable carriers, excipients or diluents that may be included include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, But are not limited to, starch, acacia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, amorphous cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, And the like.

In addition, the pharmaceutical composition of the present invention may further include a filler, an anti-coagulant, a lubricant, a wetting agent, a flavoring agent, an emulsifying agent, an antiseptic, and the like.

The pharmaceutical composition of the present invention is administered in a pharmaceutically effective amount. In the present invention, "pharmaceutically effective amount" means an amount sufficient to treat a disease at a reasonable benefit / risk ratio applicable to medical treatment, and the effective dose level will depend on the type of disease, severity, The sensitivity to the drug, the time of administration, the route of administration and the rate of release, the duration of the treatment, factors including co-administered drugs, and other factors well known in the medical arts.

The pharmaceutical composition of the present invention may be administered as an individual therapeutic agent or in combination with other therapeutic agents, and may be administered sequentially or simultaneously with conventional therapeutic agents, and may be administered singly or multiply. It is important to take into account all of the above factors and to administer the amount in which the maximum effect can be obtained in a minimal amount without side effects, which can be easily determined by those skilled in the art.

In a preferred embodiment, the effective amount of the active ingredient of the pharmaceutical composition of the present invention may vary depending on the age, sex, and body weight of the patient. In general, 0.001 to 1 mL may be administered several times daily or one to three times a day . In the present invention, "administration" means providing a predetermined substance to a patient in any suitable manner, and the administration route of the pharmaceutical composition of the present invention is any route as long as it can reach the target tissue, May be applied to the skin and administered.

The composition of the present invention may also be administered using any device capable of delivering an effective ingredient to a target cell. In the present invention, the term "object" includes, but is not limited to, human, monkey, cow, horse, sheep, pig, chicken, turkey, quail, cat, dog, mouse, rat, rabbit or guinea pig , Preferably a mammal, more preferably a human.

Hereinafter, the present invention will be described in more detail with reference to specific examples. The following examples illustrate one preferred embodiment of the present invention and are not to be construed as limiting the scope of the present invention by the matters described in the following examples.

< Example >

Example

500 ml of olive oil was put into a 1 L glass bottle, and 2 g of green pear leaves, 10 g of marigold flowers, 20 g of blue-green root, and 30 g of pestle root were immersed and placed in a light-dark cow for 1 week. The mixture was heated in a firebox at 60 to 70 DEG C for 2 hours and then cooled to prepare an oil composition of the present invention.

Comparative Example

We used a non-steroid cream form of Y, which is used for skin itching symptoms.

Experimental Example

Twenty patients suffering from herpes zoster were divided into two groups to apply the oil composition described in the examples and the cream of the comparative example, and the improvement effects of itching were compared.

Application period Example Comparative Example Before application The itching is severe and the blood is scratched. Same as left After 1 month of application Symptoms of itching appear intermittently Some improvement in itching symptoms Three months after application Almost improved symptoms of itching Homology After 6 months of application Itching symptom is cured Homology

As shown in Table 1, it was found that the oil composition of the example of the present invention is remarkably excellent in the improvement of the itching or the curing effect as compared with the commercial itching remedy.

Claims (4)

A method for the preparation of a pharmaceutical composition for the prevention or treatment of itching comprising the steps of:
(1) dipping petal leaf, marigold flower, celery root and truffle root into olive oil to form an oil composition;
(2) storing the oil composition in a cow for 5 to 10 days, the method comprising: storing the useful substance from the source pomace oil, marigold flower, green seaweed root, and tusk root for leaching with the olive oil;
(3) heating the oil composition stored in the cow at 60 to 70 DEG C for 1 to 3 hours; And
(4) cooling the oil composition obtained from the heating step. The method according to claim 1,
Wherein the itching is caused by a rash, athlete's foot, dry skin, mosquito bites, insect bites or shingles sequelae. The method according to claim 1,
In the step (1), 1 to 5 parts by weight of the green tea leaves, 5 to 20 parts by weight of the marigold flowers, 10 to 30 parts by weight of the green radish roots and 20 to 40 parts by weight of the roots of the olive oil are immersed in 100 parts by weight of the olive oil . A pharmaceutical composition for preventing or treating itch, which is obtained by the production method according to any one of claims 1 to 3.

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