KR101885269B1 - Patch composition for halt of breast-feeding and suppression of congestion in mother’s breast - Google Patents

Patch composition for halt of breast-feeding and suppression of congestion in mother’s breast Download PDF

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KR101885269B1
KR101885269B1 KR1020170036011A KR20170036011A KR101885269B1 KR 101885269 B1 KR101885269 B1 KR 101885269B1 KR 1020170036011 A KR1020170036011 A KR 1020170036011A KR 20170036011 A KR20170036011 A KR 20170036011A KR 101885269 B1 KR101885269 B1 KR 101885269B1
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patch
breast
composition
weight
parts
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이주민
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주식회사 기통테라피
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0041Mammary glands, e.g. breasts, udder; Intramammary administration

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

An object of the present invention is to provide a patch composition for inhibiting breast congestion and promoting delectation. The present invention relates to a patch composition comprising a pharmaceutical composition comprising Chrysanthemum indicum, Lycium chinense, Malva verticillata, Zingiber officinale, Plantago asiatica and Rumex crispus.

Description

수유부의 울혈 억제 및 단유를 위한 패치 조성물{PATCH COMPOSITION FOR HALT OF BREAST-FEEDING AND SUPPRESSION OF CONGESTION IN MOTHER’S BREAST}TECHNICAL FIELD [0001] The present invention relates to a patch composition for suppressing congestion and mono-ovulation of a breast part,

본 발명은 수유부의 단유 및 울혈 억제를 위한 패치 조성물에 대한 것이다.The present invention relates to a patch composition for inhibiting monoaxiality and congestion of a lactating part.

최근 출산을 안전하고 편리하게 하며, 출산 후에도 산모와 아이의 복리에 대하여 많은 연구가 이루어지고 있다(한국공개특허 10-2001-0000743호, 한국등록특허 10-1296308호, 한국공개특허 10-2009-0006587 호 등). 예컨대, 많은 산모들이 출산 직후 일정 기간 조리원에서 몸조리를 하며 아이를 돌보고 있으며, 출산 전후 마사지를 받아 임신 및 출산으로 인한 신체의 무리를 예방, 억제하고자 한다.Recently, there have been a lot of researches on maternal and child complications even after giving birth in a safe and convenient manner (Korean Patent Publication No. 10-2001-0000743, Korean Patent No. 10-1296308, Korean Patent Laid- 0006587, etc.). For example, many mothers are taking care of their children in the kitchen for a certain period of time immediately after giving birth, and they want to prevent and suppress the body discomfort due to pregnancy and childbirth by taking a massage before and after childbirth.

출산 후 산모의 신체에는 여러 가지 불편함과 고통이 생기는 경우가 많은데, 예컨대, 유선염, 부종, 변비, 요실금, 산욕열, 회음부 통증, 유방 울혈 등이 있다. 그 중 유방 울혈은 모유가 생기면서 여분의 혈액과 림프액이 유방으로 들어오는데, 모유량이 급격히 증가하거나 수유가 제대로 이루어지지 않아 유방 내 모유가 찰 때 발생하는 것으로 알려져 있다. 울혈이 생기면 모유가 잘 나오지 않고, 부종이 심해지며 유방이 화끈거리고 단단해지며 통증이 생기게 된다. 또한 유방 울혈이 계속되는 경우 산욕열 및 유선염이 발생하게 된다.There are many inconveniences and suffering in the mother's body after giving birth, for example, mastitis, edema, constipation, urinary incontinence, heat of swallowing, perineal pain and breast congestion. It is known that breast congestion occurs when excess blood and lymph fluid enters the breast as the breast milk is being produced, because the breast milk volume increases sharply or the breast milk is not made properly. If congestion occurs, the breast milk does not come out well, the edema becomes worse, and the breast gets hot, hard, and painful. Also, if breast congestion continues, it will cause swelling and mastitis.

한편, 산모가 모유 수유 또는 혼합 수유를 하는 경우, 일정 기간의 수유 기간이 지나면, 단유를 하게 된다. 이 때 모유를 먹이는 아기 엄마, 즉 수유부는 모유의 분비를 줄이고 최종적으로 모유 분비를 중단하는 단유 과정을 거치게 되는데, 이 과정에서 유방 부종, 통증 등과 같은 울혈을 겪거나 모유 분비량이 잘 감소하지 않는 곤란을 겪게 된다.On the other hand, if the mother breast-feeds or mixed, she will be breast-fed after a period of lactation. In this case, a mother who feeds breast milk, that is, the breastfeeding department reduces the secretion of breast milk, and ultimately, the breast milk is cut off the process is going through the process, such as breast swelling and pain, such as suffering from congestion, .

본 발명자들은 구강 섭취를 하지 않고도 유방 울혈을 억제하고, 단유를 순조롭게 할 수 있는 방법을 연구하던 중 특정 약재를 이용한 패치 조성물을 발명하였다.The inventors of the present invention invented a patch composition using a specific medicinal substance while studying a method of suppressing breast congestion and facilitating mono-oil without oral intake.

본 발명의 목적은 유방 울혈 억제 및 단유 촉진을 위한 패치 조성물을 제공하는 것이다.It is an object of the present invention to provide a patch composition for inhibiting breast congestion and promoting mono-oily.

상기 목적을 달성하기 위하여 본 발명은 감국, 구기자, 동규자, 건강, 차전초 및 소루쟁이를 포함하는 약재 조성물을 포함하는 패치 조성물을 제공한다.In order to attain the above object, the present invention provides a patch composition comprising a medicinal composition comprising a mung bean, a mackerel, a mackerel, a health, a herb, and a tortoise.

본 발명의 패치 조성물은 유방 울혈 억제 및 단유 촉진 효능을 갖는다.The patch composition of the present invention has mammalian congestion suppression and mono-milk promoting effect.

도 1은 본 발명의 패치 조성물이 함침된 베이스 시트를 나타낸다.
도 2는 상기 베이스 시트를 피부에 갖다 댄 후 이를 덮어서 점착시키는 점착 시트를 적용한 형태를 나타낸다.
도 3은 본 발명의 패치를 부착하는 위치를 나타낸다.
Figure 1 shows a base sheet impregnated with the patch composition of the present invention.
FIG. 2 shows an embodiment in which the base sheet is applied to the skin, and then the adhesive sheet is applied to cover the base sheet.
Figure 3 shows the location of attachment of the patch of the present invention.

본 발명은The present invention

감국, 구기자, 동규자, 건강, 차전초 및 소루쟁이를 포함하는 약재 조성물을 포함하는 패치 조성물에 대한 것이다.A patch composition comprising a medicinal composition comprising a mucilage, a mushroom, a mushroom, a health, a herbicide and a mushroom.

이하, 본 발명을 자세히 설명한다.Hereinafter, the present invention will be described in detail.

약재 조성물Medicinal composition

본 발명은 감국, 구기자, 동규자, 건강, 차전초 및 소루쟁이를 포함하는 약재 조성물을 포함하는 패치 조성물에 대한 것이다. 이 때 상기 약재 조성물은 다시마, 함초, 민들래 및 무말랭이를 추가로 포함할 수 있다. 또한 상기 약재 조성물은 겨우살이, 익모초, 감초, 당귀 및 감잎을 추가로 포함할 수 있다.The present invention is directed to a patch composition comprising a medicinal composition comprising a germ, a gum, a gum, a health, a gum, and a gum. Wherein said medicinal composition may further comprise kelp, green tea, mulberry, and radish. The pharmaceutical composition may further comprise mistletoe, motherwort, licorice, Angelica gigas, and persimmon leaves.

이 때, 상기 약재 조성물은 감국 100 중량부에 대하여, 구기자 80 내지 130 중량부, 동규자 150 내지 200 중량부, 건강 150 내지 200 중량부, 차전초 80 내지 150 중량부, 소루쟁이 80 내지 130 중량부, 다시마 100 내지 170 중량부, 함초 200 내지 280 중량부, 민들레 30 내지 60 중량부, 무말랭이 150 내지 200 중량부, 겨우살이 100 내지 170 중량부, 익모초 80 내지 150 중량부, 감초 50 내지 130 중량부, 당귀 140 내지 190 중량부, 감잎 160 내지 240 중량부를 포함하는 것이 바람직하다.In this case, the pharmaceutical composition may contain 80 to 130 parts by weight of ginger, 150 to 200 parts by weight of ginger, 150 to 200 parts by weight of health, 80 to 150 parts by weight of herbicide, 80 to 130 parts by weight of ginger, 100 to 170 parts by weight of sea tangle, 200 to 280 parts by weight of seaweed, 30 to 60 parts by weight of dandelion, 150 to 200 parts by weight of radish, 100 to 170 parts by weight of mistletoe, 80 to 150 parts by weight of motherwort, 50 to 130 parts by weight of licorice, 140 to 190 parts by weight, and persimmon leaves of 160 to 240 parts by weight.

본 발명의 약재 조성물은 상기 약재들을 상온에서 에탄올 추출 후 여과하고, 이를 가열 농축하여 제조한다. The medicinal composition of the present invention is prepared by extracting the above medicaments with ethanol at room temperature, filtering the mixture, and concentrating the mixture by heating.

패치 조성물Patch composition

본 발명의 패치 조성물은 수유부의 단유를 촉진한다. 또한 본 발명의 패치 조성물은 수유부의 유방의 열감을 억제한다. 또한 본 발명의 패치 조성물은 수유부의 유방의 부종 및 통증을 억제한다.The patch composition of the present invention promotes mono-oiling of the feeding section. Further, the patch composition of the present invention suppresses the heat sensation of the breast of the lactating part. In addition, the patch composition of the present invention suppresses edema and pain in the breast of the breast part.

본 발명의 패치 조성물은 베이스 시트에 함침시켜 패치를 제조하는데 이용된다. 이렇게 제조된 패치는 점착 시트를 이용하여 수유부의 신체에 1시간 내지 28 시간 부착된다. 도 1은 본 발명의 패치 조성물이 함침된 베이스 시트(2)를 나타낸다. 이것은 위생을 위하여 피부에 부착되는 부분은 떼어낼 수 있는 비닐 시트(1)로 덮여 있다. 도 2는 상기 베이스 시트를 피부에 갖다 댄 후 이를 덮어서 점착시키는 점착 시트 (3)를 적용한 형태를 나타낸다. 도 3은 본 발명의 패치를 부착하는 위치를 나타낸다.The patch composition of the present invention is used to prepare a patch by impregnating the base sheet. The patch thus prepared is attached to the body of the lactating part using the adhesive sheet for 1 to 28 hours. 1 shows a base sheet 2 impregnated with the patch composition of the present invention. This is covered with a removable vinyl sheet 1 for sanitary purposes. FIG. 2 shows a state in which the base sheet is applied to the skin, and then the adhesive sheet 3 is applied to cover the base sheet. Figure 3 shows the location of attachment of the patch of the present invention.

본 발명의 이점 및 특징, 그리고 그것들을 달성하는 방법은 상세하게 후술되어 있는 실시예들을 참조하면 명확해질 것이다. 그러나, 본 발명은 이하에서 개시되는 실시예들에 한정되는 것이 아니라 서로 다른 다양한 형태로 구현될 것이며, 단지 본 실시예들은 본 발명의 개시가 완전하도록 하며, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 발명의 범주를 완전하게 알려주기 위해 제공되는 것이며, 본 발명은 청구항의 범주에 의해 정의될 뿐이다.Advantages and features of the present invention and methods of achieving them will become apparent with reference to the embodiments described in detail below. It should be understood, however, that the invention is not limited to the disclosed embodiments, but is capable of many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, To fully disclose the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims.

<재료 및 방법>&Lt; Materials and methods >

한약재인 건강, 차전초(질경이 잎), 소루쟁이(뿌리줄기), 다시마, 함초(전초), 민들레(전초), 무말랭이, 겨우살이(나무 줄기), 익모초의 지상부(줄기 및 잎), 감초, 당귀(뿌리), 감잎 및 감국(꽃)은 시판되는 제품을 구입하여, 55 ℃로 저온에서 열풍건조하여 이용하였다. 구기자 및 동규자는 시판되는 건조된 종자를 구입하였다. The main ingredients of the medicinal herbs such as health, herbaceous plant, rootstock, kelp, green onion, dandelion, salmon, mistletoe, stem and leaf of licorice, licorice, Roots), persimmon leaves and sweet potatoes (flowers) were purchased from commercial products and used by hot air drying at 55 ° C at low temperature. Gugija and Dongjiao purchased commercially available dried seeds.

건조된 건강, 차전초, 소루쟁이, 다시마, 함초, 민들레, 무말랭이, 겨우살이, 익모초의 지상부, 감초, 당귀, 감잎 및 감국을 분쇄기를 이용하여 미립분쇄하여 분말화하여 이용하였다. 구기자 및 동규자 역시 분쇄기를 이용하여 미립분쇄하여 분말화하여 이용하였다.Dried powder, dried seaweed, ginseng, mulberry, kelp, green tea, dandelion, radish, mistletoe, motherwort, licorice, Angelica gigantei, persimmon leaf and gruel were pulverized and pulverized into fine powders. The gugija and gangja were also pulverized and pulverized using a pulverizer.

베이스 시트 및 접착 시트는 판매되는 제품을 구입하여 사용하였다.The base sheet and the adhesive sheet were purchased and used.

<실시예 1>&Lt; Example 1 >

하기 표 1의 중량비로 성분들을 혼합하여 1차 혼합물을 제조하였다. 에탄올, 상기 혼합물 및 정제수를 100 : 50: 50의 중량비로 혼합하여 2차 혼합물을 제조하고, 상기 2차 혼합물을 밀폐 상태에서 7일 동안 1차 숙성시켰다. 1차 숙성 후 리본 믹서(리본형 혼합기)를 이용하여 1차 숙성물들을 다시 한 번 교반하여 잘 섞은 후, 다시 밀폐 상태에서 7일 동안 2차 숙성을 진행하였다. 그리고 2창 숙성기간인 7일이 도과한 후 상기 2차 숙성물을 압축기 및 1,0000 메쉬 여과포를 이용하여 1차 여과하였다. 그리고 1차 여과물을 48 시간 동안 밀폐하여 보관한 후 2,000 메쉬 여과포를 이용하여 2차 여과하였다. 그리고 2차 여과물을 수득한 후 2중 가열 탱크에서 80 ℃로 가열하여, 60 중량%를 수득하였다(즉, 2차 여과물 100 중량%가 가열 후 60 중량%로 되고, 나머지 40 중량%는 에탄올 증발로 사라짐). 상기 수득물을 방부제 처리한 후 밀폐하여 보관하였다. The components were mixed in the weight ratio shown in Table 1 below to prepare a primary mixture. Ethanol, the mixture and the purified water were mixed at a weight ratio of 100: 50: 50 to prepare a second mixture, and the second mixture was first aged for 7 days in an airtight state. After the first aging, the primary aged materials were agitated again using a ribbon mixer (ribbon type mixer), and then aged for 7 days in a sealed state again. After 2 days of ripening, the secondary aged material was subjected to primary filtration using a compressor and 1,0000 mesh filter cloth. The primary filtrate was kept sealed for 48 hours and then subjected to secondary filtration using a 2,000 mesh filter cloth. Then, a secondary filtrate was obtained and heated to 80 ° C. in a double heating tank to obtain 60 wt% (ie, 100 wt% of the secondary filtrate was 60 wt% after heating, and the remaining 40 wt% Evaporated by ethanol evaporation). The obtained product was preserved and then sealed.

그리고 일주일 동안 보관한 후 상기 수득물(이하, “패치 조성물” 이라 함)에 베이스 시트를 함침시켜, 패치를 제조하였다. After storing for one week, the resulting product (hereinafter referred to as "patch composition") was impregnated with a base sheet to prepare a patch.

Figure 112018015238024-pat00006
Figure 112018015238024-pat00006

Figure 112018015238024-pat00007
Figure 112018015238024-pat00007

<실험예 1> 단유 촉진능<Experimental Example 1>

상기 실시예 1 및 비교예 1 내지 10의 패치들을 이용하여 단유 촉진능을 평가하였다. 패널은 25세 내지 36세의 수유하는 아기 엄마들 62명으로, 이들은 단유 계획이 있는 사람들이었다. 패치를 도 3과 같이 가슴에 부착하고 12시간 내지 18시간 후 맛사지를 한 후 패치를 떼어내었다. 그리고 유축(완전 착유)을 한 후 다시 패치를 가슴에 부착하고 18시간 내지 24시간 후 맛사지를 하고 패치를 떼어내었다. 그리고 유축(완전 착유)을 한 후 다시 패치를 가슴에 부착하고 12시간 내지 18시간 후 맛사지를 하고 패치를 떼어 내었다. 그리고 유축(30% 정도 부분 착유)을 한 후 다시 패치를 가슴에 부착하고 18시간 내지 24시간 후 맛사지를 하고 패치를 떼어내었다. 그리고 유축(30% 정도 부분 착유)을 한 후 다시 패치를 가슴에 부착하고 이틀 동안 지냈다.The mono-oil promoting ability was evaluated using the patches of Example 1 and Comparative Examples 1 to 10 above. The panel consisted of 62 infant mothers from 25 to 36 years old, who had a single-breasted plan. The patch was attached to the chest as shown in Fig. 3, and after 12 to 18 hours of massage, the patch was removed. Then, after the milking (complete milking), the patch was attached to the chest again, and after 18 to 24 hours, the massage was performed and the patch was removed. After the milking (complete milking), the patch was attached to the chest again, and after 12 to 18 hours, the massage was performed and the patch was taken off. Then, after pouring (30% partial milking), the patch was attached to the chest again, and after 18 to 24 hours, massage was performed and the patch was removed. Then, after pouring (30% partial milking), the patch was attached to the chest for two days.

그 후 단유 정도 및 울혈로 인한 통증 정도를 5점 척도법을 이용하여 평가하였다. After that, degree of monoaxiality and degree of pain due to congestion were evaluated using the 5 - point scaling method.

단유 : 5점: 완전 단유, 4점: 거의 단유되어 추가 조치 필요 없음, 3점: 어느 정도 단유가 되었으나 추가 조치 필요(단유 크림, 엿기름 등 필요), 2점: 변화 없음, 1점: 모유량 증가2 points: no change, 1 point: increase in breastfeeding, 2 points: no change, 1 point: no need for additional measures, 3 points:

통증 : 5점: 통증 없음, 4점: 통증 거의 없으며, 불편한 정도는 아님, 3점: 약간 통증 있으며 불편함, 2점: 통증 있으며 추가 조치 필요(맛사지, 냉찜질 등 필요), 1점: 통증 심함Pain: 5 points: No pain, 4 points: No pain, no discomfort, 3 points: Slight pain, discomfort, 2 points: Pain, additional measures needed (massage,

부종: 5: 부종 없음, 4: 부종이 약간 있으나 불편한 정도는 아님, 3: 부종이 있으며 좀 불편함, 2: 부종이 있으며 추가 조치 필요(맛사지, 냉찜질 등 필요), 1: 종이 심함Edema: 5: No edema, 4: Some edema but not uncomfortable, 3: Edema and mild discomfort, 2: Swelling and additional measures needed (massage, cold)

선호도; 5: 매우 좋음(적극 구입 의사 있음), 4: 좋음(구입 의사 있음) 3:보통, 2: 나쁨, 1: 매우 나쁨(구입 의사 전혀 없음). preference; 3: Normal, 2: Poor, 1: Very poor (no purchase at all). 5: Very good.

그 결과, 실시예 1의 패치는 대부분의 패널들에게서 단유 효능을 보였으며, 울혈로 인한 통증이나 부종도 양호한 것으로 나타났다. 그 외 비교예 6 및 10의 패치도 단유 효능이 우수하였으나, 울혈로 인한 통증 및 부종이 꽤 있는 편이었다(표 2).As a result, the patch of Example 1 showed mono-oily efficacy in most of the panels, and pain and swelling due to congestion were also good. The patches of Comparative Examples 6 and 10 were also excellent in monounsaturated efficacy, but there was considerable pain and swelling due to congestion (Table 2).

단유Mono 통증ache 부종edema 선호도preference 실시예 1Example 1 4.24.2 4.44.4 4.04.0 4.34.3 비교예 1Comparative Example 1 3.73.7 3.23.2 4.14.1 3.53.5 비교예 2Comparative Example 2 2.92.9 3.93.9 4.24.2 3.23.2 비교예 3Comparative Example 3 3.63.6 4.04.0 3.33.3 3.83.8 비교예 4Comparative Example 4 2.72.7 2.82.8 3.83.8 2.42.4 비교예 5Comparative Example 5 2.82.8 4.24.2 3.73.7 3.93.9 비교예 6Comparative Example 6 4.24.2 2.52.5 3.13.1 3.13.1 비교예 7Comparative Example 7 3.13.1 4.14.1 2.82.8 3.63.6 비교예 8Comparative Example 8 2.32.3 3.13.1 3.43.4 3.73.7 비교예 9Comparative Example 9 2.62.6 3.83.8 3.93.9 3.03.0 비교예 10Comparative Example 10 4.14.1 2.92.9 2.82.8 3.13.1

<실험예 2> 울혈 억제능&Lt; Experimental Example 2 >

상기 실시예 1 및 비교예 1 내지 10의 패치들을 이용하여 출산 후 유방의 울혈 생성 억제능을 평가하였다. 패널은 출산 후 15일 이내의 25세 내지 36세의 산모들 90명이었다. 산모들은 유방에 열감 및 통증이 시작될 때, 도 3과 같이 패치를 부착하였다. 부착한 패치는 2 ~ 3시간 후 떼었다 다시 새 제품을 부착하였으며(7회 반복), 규칙적으로 모유 수유 및 유축을 하였다. The patches of Example 1 and Comparative Examples 1 to 10 were used to evaluate the ability of the breast to inhibit congestion formation after delivery. The panel included 90 mothers between the ages of 25 and 36 within 15 days of giving birth. Mothers attached patches as shown in Fig. 3 when heat and pain started on the breasts. The attached patch was detached after 2 to 3 hours and the new product was attached again (7 times), and breastfeeding and pouring were performed regularly.

그리고 열감, 통증 및 부종 정도를 평가하여, 각 패치의 울혈 억제능을 평가하였다. 전체적인 선호도 또한 평가하였다.The degree of fever, pain, and edema were evaluated and the inhibition of congestion of each patch was evaluated. Overall preferences were also assessed.

열감; 5: 열감 없음, 4: 열감 약간 있으나 불편한 정도는 아님, 3: 열감이 있으며 좀 불편함, 2: 열감이 있으며 많이 불편함, 1: 열감이 많음Fever; 5: No fever, 4: A little fever but not uncomfortable, 3: Feeling hot and uncomfortable, 2: Feeling hot and uncomfortable, 1: Feeling hot

통증; 5: 통증 없음, 4: 통증이 약간 있으나 불편한 정도는 아님, 3: 통증이 있으며 좀 불편함, 2: 통증이 있으며 추가 조치 필요(맛사지, 냉찜질 등 필요), 1: 통증이 심함ache; 5: No pain, 4: Some pain but not uncomfortable, 3: Pain and discomfort, 2: Pain and additional measures needed (massage, cold)

부종: 5: 부종 없음, 4: 부종이 약간 있으나 불편한 정도는 아님, 3: 부종이 있으며 좀 불편함, 2: 부종이 있으며 추가 조치 필요(맛사지, 냉찜질 등 필요), 1: 종이 심함Edema: 5: No edema, 4: Some edema but not uncomfortable, 3: Edema and mild discomfort, 2: Swelling and additional measures needed (massage, cold)

선호도; 5: 매우 좋음(적극 구입 의사 있음), 4: 좋음(구입 의사 있음) 3:보통, 2: 나쁨, 1: 매우 나쁨(구입 의사 전혀 없음). preference; 3: Normal, 2: Poor, 1: Very poor (no purchase at all). 5: Very good.

그 결과, 실시예 1의 패치는 열감, 통증, 부종의 완화능이 우수하여 울혈 억제 효능이 뛰어난 것으로 확인되었다. 한편, 비교예 2 및 5의 패치의 경우 통증 억제 효능이 뛰어 났고, 비교예 7의 패치는 열감 완화능이 우수하였다. 그러나 비교예 2, 5 및 7의 패치들은 열감, 통증, 부종 모두를 완화시키지는 않는 것으로 확인되었다(표 3).As a result, it was confirmed that the patch of Example 1 was excellent in relieving fever, pain, edema and excellent anticancer effect. On the other hand, the patches of Comparative Examples 2 and 5 were excellent in pain control efficacy, and the patch of Comparative Example 7 was excellent in heat-releasing ability. However, the patches of Comparative Examples 2, 5, and 7 did not alleviate both hot sensation, pain, and edema (Table 3).

열감Fever 통증ache 부종edema 선호도preference 실시예 1Example 1 4.34.3 4.24.2 3.83.8 4.14.1 비교예 1Comparative Example 1 3.23.2 2.72.7 3.53.5 3.13.1 비교예 2Comparative Example 2 3.33.3 4.04.0 2.62.6 3.73.7 비교예 3Comparative Example 3 2.32.3 3.23.2 2.42.4 2.82.8 비교예 4Comparative Example 4 2.92.9 3.43.4 2.82.8 2.62.6 비교예 5Comparative Example 5 2.52.5 4.14.1 3.13.1 3.23.2 비교예 6Comparative Example 6 2.82.8 3.93.9 3.53.5 3.43.4 비교예 7Comparative Example 7 4.24.2 3.83.8 2.42.4 3.73.7 비교예 8Comparative Example 8 3.33.3 3.73.7 2.62.6 3.13.1 비교예 9Comparative Example 9 3.23.2 2.92.9 3.03.0 3.33.3 비교예 10Comparative Example 10 3.43.4 2.62.6 3.13.1 2.92.9

Claims (10)

감국, 구기자, 동규자, 건강, 차전초 및 소루쟁이를 포함하는 약재 조성물을 포함하며,
수유부의 유방의 열감, 부종 또는 통증을 억제하는,
패치 조성물.
Comprising a medicinal composition comprising a compound of formula (I), a compound of formula (I), a compound of formula (I), a compound of formula (I)
Which suppresses the fever, swelling or pain of the breast of the breastfeeding,
Patch composition.
제 1항에 있어서,
상기 약재 조성물은 다시마, 함초, 민들래 및 무말랭이를 추가로 포함하는 것을 특징으로 하는 패치 조성물.
The method according to claim 1,
Wherein said medicinal composition further comprises kelp, green tea, mulberry, and radish.
제 1항에 있어서,
상기 약재 조성물은 겨우살이, 익모초, 감초, 당귀 및 감잎을 추가로 포함하는 것을 특징으로 하는 패치 조성물.
The method according to claim 1,
Wherein the pharmaceutical composition further comprises mistletoe, motherwort, licorice, Angelica gigas, persimmon leaves.
제 1항에 있어서,
상기 패치 조성물은 수유부의 단유를 촉진하는 것을 특징으로 하는 패치 조성물.
The method according to claim 1,
Wherein the patch composition promotes mono-oiling of the feeding section.
삭제delete 삭제delete 삭제delete 제 1항에 있어서,
약재 조성물은 감국, 구기자, 동규자, 건강, 차전초 및 소루쟁이를 혼합한 후 이를 에탄올 추출하여 제조하는 것을 특징으로 하는 패치 조성물.
The method according to claim 1,
The patch composition according to claim 1, wherein the medicinal composition is prepared by mixing gingko noodles, gingko ginseng, young ginseng, health ginseng, tea ginseng, and water ginseng followed by ethanol extraction.
제 1항에 있어서,
상기 약재 조성물은 감국 100 중량부에 대하여, 구기자 80 내지 130 중량부, 동규자 150 내지 200 중량부, 건강 150 내지 200 중량부, 차전초 80 내지 150 중량부, 소루쟁이 80 내지 130 중량부를 포함하는 것을 특징으로 하는 패치 조성물.
The method according to claim 1,
The medicinal composition is characterized in that it comprises 80 to 130 parts by weight of gugija, 150 to 200 parts by weight of gugija, 150 to 200 parts by weight of health, 80 to 150 parts by weight of herbal gum, and 80 to 130 parts by weight of gug, Lt; / RTI &gt;
제 1항에 있어서,
상기 패치 조성물은 수유부의 신체에 1시간 내지 28시간 부착하여 이용하는 것을 특징으로 하는 패치 조성물.
The method according to claim 1,
Wherein the patch composition is applied to the body of the lactating part for 1 to 28 hours.
KR1020170036011A 2017-03-22 2017-03-22 Patch composition for halt of breast-feeding and suppression of congestion in mother’s breast KR101885269B1 (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090123458A (en) * 2008-05-28 2009-12-02 주식회사 엘씨에스바이오텍 A method for fermentation of natural plants or herbal medicines, a fermented product prepared therefrom and a cosmetic composition, a food composition and a pharmaceutical composition comprising the same
KR20140049673A (en) * 2012-10-18 2014-04-28 반계선 Manufacturing method of the enzyme using 125 kinds of medicinal herb extracts (extract using extract by the co2 (or n2) carrier gas method, enzyme extract by the fermentation method, microwave and filter)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090123458A (en) * 2008-05-28 2009-12-02 주식회사 엘씨에스바이오텍 A method for fermentation of natural plants or herbal medicines, a fermented product prepared therefrom and a cosmetic composition, a food composition and a pharmaceutical composition comprising the same
KR20140049673A (en) * 2012-10-18 2014-04-28 반계선 Manufacturing method of the enzyme using 125 kinds of medicinal herb extracts (extract using extract by the co2 (or n2) carrier gas method, enzyme extract by the fermentation method, microwave and filter)

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