KR101881692B1 - 색소가 결합된 만노실 혈청 알부민 복합체 및 이를 포함하는 림프절 탐지용 조성물 - Google Patents

색소가 결합된 만노실 혈청 알부민 복합체 및 이를 포함하는 림프절 탐지용 조성물 Download PDF

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KR101881692B1
KR101881692B1 KR1020170033770A KR20170033770A KR101881692B1 KR 101881692 B1 KR101881692 B1 KR 101881692B1 KR 1020170033770 A KR1020170033770 A KR 1020170033770A KR 20170033770 A KR20170033770 A KR 20170033770A KR 101881692 B1 KR101881692 B1 KR 101881692B1
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South Korea
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conjugated
dye
serum albumin
lymph node
mannosylated
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KR1020170033770A
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정재민
이윤상
이지연
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서울대학교산학협력단
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Priority to KR1020170033770A priority Critical patent/KR101881692B1/ko
Priority to EP18766993.2A priority patent/EP3597224B1/en
Priority to US16/494,709 priority patent/US20200009275A1/en
Priority to JP2019551334A priority patent/JP6748789B2/ja
Priority to PCT/KR2018/003106 priority patent/WO2018169356A1/ko
Priority to CN201880018249.1A priority patent/CN110430902A/zh
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Publication of KR101881692B1 publication Critical patent/KR101881692B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B68/00—Organic pigments surface-modified by grafting, e.g. by establishing covalent or complex bonds, in order to improve the pigment properties, e.g. dispersibility or rheology
    • C09B68/40—Organic pigments surface-modified by grafting, e.g. by establishing covalent or complex bonds, in order to improve the pigment properties, e.g. dispersibility or rheology characterised by the chemical nature of the attached groups
    • C09B68/41—Polymers attached to the pigment surface

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

본 발명은 색소가 결합된 만노실 혈청 알부민 복합체 및 이를 포함하는 림프절 탐지용 조성물에 관한 것으로, 구체적으로, 색소가 결합된 만노실 혈청 알부민 복합체가 마우스에 투여되면 대퇴부 림프절에 응집된 상태로 오랜시간 동안 유지되는 것을 육안으로 확인할 수 있으므로, 상기 복합체 및 이를 포함하는 조성물은 림프절의 탐지에 유용하게 사용할 수 있다.
KR1020170033770A 2017-03-17 2017-03-17 색소가 결합된 만노실 혈청 알부민 복합체 및 이를 포함하는 림프절 탐지용 조성물 KR101881692B1 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1020170033770A KR101881692B1 (ko) 2017-03-17 2017-03-17 색소가 결합된 만노실 혈청 알부민 복합체 및 이를 포함하는 림프절 탐지용 조성물
EP18766993.2A EP3597224B1 (en) 2017-03-17 2018-03-16 Pigment-coupled mannosyl serum albumin complex and lymph node-probing composition comprising same
US16/494,709 US20200009275A1 (en) 2017-03-17 2018-03-16 Pigment-coupled mannosyl serum albumin complex and lymph node-probing composition comprising same
JP2019551334A JP6748789B2 (ja) 2017-03-17 2018-03-16 色素カップリングマンノシル血清アルブミン複合体およびこれを含むリンパ節プロービング組成物
PCT/KR2018/003106 WO2018169356A1 (ko) 2017-03-17 2018-03-16 색소가 결합된 만노실 혈청 알부민 복합체 및 이를 포함하는 림프절 탐지용 조성물
CN201880018249.1A CN110430902A (zh) 2017-03-17 2018-03-16 色素偶联的甘露糖基血清白蛋白复合物和包含该复合物的淋巴结探测组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020170033770A KR101881692B1 (ko) 2017-03-17 2017-03-17 색소가 결합된 만노실 혈청 알부민 복합체 및 이를 포함하는 림프절 탐지용 조성물

Publications (1)

Publication Number Publication Date
KR101881692B1 true KR101881692B1 (ko) 2018-07-25

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KR1020170033770A KR101881692B1 (ko) 2017-03-17 2017-03-17 색소가 결합된 만노실 혈청 알부민 복합체 및 이를 포함하는 림프절 탐지용 조성물

Country Status (6)

Country Link
US (1) US20200009275A1 (ko)
EP (1) EP3597224B1 (ko)
JP (1) JP6748789B2 (ko)
KR (1) KR101881692B1 (ko)
CN (1) CN110430902A (ko)
WO (1) WO2018169356A1 (ko)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000074727A2 (en) * 1999-06-04 2000-12-14 Resolution Pharmaceuticals, Inc. Radiopharmaceuticals and methods for imaging
KR20040098319A (ko) * 2003-05-14 2004-11-20 정재민 림프계 영상을 위한 디설파이드 환원형 만노즈결합혈청알부민 및 이를 포함한 방사성동위원소 표지 화합물
KR20100087511A (ko) * 2009-01-28 2010-08-05 서울대학교산학협력단 면역세포 영상화 및 탐지를 위한 양기능성킬레이트제와 만노실 인혈청알부민의 결합체 및 그의 방사성동위원소 표지 화합물
KR20160020296A (ko) 2014-08-13 2016-02-23 고려대학교 산학협력단 인도시아닌그린이 결합된 만노실 혈청알부민 복합체, 이의 제조방법, 이를 포함하는 광학영상 프로브 및 키트

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1419787A1 (de) * 2002-11-18 2004-05-19 Uwe Prof. Dr. Till Lymphknoten-Kontrastmittel
KR101228147B1 (ko) * 2010-08-13 2013-01-31 국립암센터 방사성 동위원소가 표지되고 근적외선 영역의 형광색소 및 가시광선 영역의 색소가 결합된 알부민을 포함하는 감시림프절 표지자

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000074727A2 (en) * 1999-06-04 2000-12-14 Resolution Pharmaceuticals, Inc. Radiopharmaceuticals and methods for imaging
KR20040098319A (ko) * 2003-05-14 2004-11-20 정재민 림프계 영상을 위한 디설파이드 환원형 만노즈결합혈청알부민 및 이를 포함한 방사성동위원소 표지 화합물
KR100557008B1 (ko) 2003-05-14 2006-03-03 정재민 림프계 영상을 위한 디설파이드 환원형 만노즈결합혈청알부민 및 이를 포함한 방사성동위원소 표지 화합물
KR20100087511A (ko) * 2009-01-28 2010-08-05 서울대학교산학협력단 면역세포 영상화 및 탐지를 위한 양기능성킬레이트제와 만노실 인혈청알부민의 결합체 및 그의 방사성동위원소 표지 화합물
KR20160020296A (ko) 2014-08-13 2016-02-23 고려대학교 산학협력단 인도시아닌그린이 결합된 만노실 혈청알부민 복합체, 이의 제조방법, 이를 포함하는 광학영상 프로브 및 키트

Also Published As

Publication number Publication date
EP3597224A1 (en) 2020-01-22
JP6748789B2 (ja) 2020-09-02
EP3597224B1 (en) 2022-01-12
WO2018169356A1 (ko) 2018-09-20
US20200009275A1 (en) 2020-01-09
JP2020511474A (ja) 2020-04-16
CN110430902A (zh) 2019-11-08
EP3597224A4 (en) 2020-04-01
WO2018169356A9 (ko) 2019-11-14

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