KR101868346B1 - Cuvette device for optical measurement of blood sample and bio optical measurement device having the cuvette device - Google Patents

Cuvette device for optical measurement of blood sample and bio optical measurement device having the cuvette device Download PDF

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Publication number
KR101868346B1
KR101868346B1 KR1020170096013A KR20170096013A KR101868346B1 KR 101868346 B1 KR101868346 B1 KR 101868346B1 KR 1020170096013 A KR1020170096013 A KR 1020170096013A KR 20170096013 A KR20170096013 A KR 20170096013A KR 101868346 B1 KR101868346 B1 KR 101868346B1
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plate
transmission window
cuvette
opening
light
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KR1020170096013A
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Korean (ko)
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김영민
한진권
안다미
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주식회사 미코바이오메드
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Disclosed is a cuvette apparatus having a blood injection port into which a blood sample is injected and having an internal space for accommodating the injected blood sample. The cuvette device includes a first plate having a first transmission window for transmitting light, a second plate disposed on the first plate and having a second transmission window exposing the entire first transmission window, And a chamber plate having a first opening formed to expose an entire first transmission window area from a first corner where the blood injection port is located to form an inner space together with the first and second plates.

Description

TECHNICAL FIELD [0001] The present invention relates to a cuvette device for optical measurement of blood, and a bio-optical measurement device including the same. [0002]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cuvette apparatus capable of receiving a blood sample and performing optical measurement, and a biooptical measurement apparatus having the same.

In recent years, interest in health has increased with the aging society, and various portable blood testing devices are being developed. Such a blood test apparatus receives blood directly from the human body and tests blood through various methods.

Among such blood testing devices, optical testing devices generally require a cuvette container to contain blood. Specifically, a cuvette container accommodating a blood sample is mounted in an optical inspection apparatus, and then light is irradiated. Optical inspection of the blood sample is performed by collecting and analyzing light passing through the blood sample. On the other hand, as the cuvette container, a transparent container as a whole was generally used.

However, when the cuvette container as described above is used, the deviation of the incident angle of the light incident on the light receiving element due to the scattered light due to the blood is widened, which may cause a large measurement deviation, A problem arises.

It is an object of the present invention to provide a cuvette device capable of reducing the angular deviation of emitted light.

It is another object of the present invention to provide a bio-optical measurement apparatus having the cuvette apparatus.

A cuvette device according to an embodiment of the present invention includes a first plate having a blood inlet for injecting a blood sample and having an internal space for accommodating the injected blood sample and having a first transmission window for transmitting light therethrough; A second plate disposed above the first plate, the second plate having a larger area than the first transmission window and exposing the entire first transmission window; And a second plate disposed between the first plate and the second plate and extending from a first corner where the blood injection port is located to a second corner direction opposite to the first corner, And a chamber plate having a first opening for forming the inner space together with the first and second plates.

In one embodiment, the width of the first opening in the first direction orthogonal to the direction in which the blood is injected is greater than the width in the first direction of the first transmissive window, and the width of the first transmissive window Direction and may be the same. For example, the width of the first opening in the first direction may be smaller than the width of the second transmission window in the first direction.

In one embodiment, the second transmissive window may be formed to extend from the first edge of the second plate to expose the blood injection port. Alternatively, the second transmissive window may be formed to extend from a position away from the first corner of the second plate to a second corner of the second plate opposite to the first corner.

In one embodiment, the first plate may include a first base plate formed of a transparent polymer material, and a first light blocking coating layer coated on a lower surface of the first base plate and blocking light, The light blocking coating layer may have a second opening to form the first transmission window.

In one embodiment, the second plate may include a second base plate formed of a transparent polymer material, and a second light blocking coating layer coated on the upper surface of the second base plate and blocking light, The light blocking coating layer may have a third opening to form the second transmission window. In this case, the first light blocking coating layer and the second light blocking coating layer may have a hydrophobic property.

In one embodiment, the cuvette device may further include a sensing electrode formed on an upper surface of the first plate, at least a portion of which is located in the inner space, and sensing a blood sample injected into the inner space .

A bio-optical measuring apparatus according to an embodiment of the present invention includes a first plate having a first transmission window for transmitting light, a second plate disposed on the first plate, having a larger area than the first transmission window, A second plate having a second permeable window formed thereon and a second plate disposed between the first plate and the second plate and extending from a first edge where the blood injection port is located to a second edge direction opposite to the first edge, And a chamber plate having a first opening formed therein and exposing the entire first transmissive window, the chamber plate defining an interior space in which the blood is received together with the first and second plates; A housing unit including a body portion having an insertion space into which the cuvette device is inserted, and a grip portion disposed inside the insertion space and holding a part of the cuvette device; And a light emitting element and a light receiving element coupled to the body portion so as to be opposed to each other with the cuvette device interposed therebetween.

In one embodiment, the width of the first opening in the first direction orthogonal to the direction in which the blood sample is injected is larger than the width in the first direction of the first transmission window, May be less than or equal to the width in one direction.

In one embodiment, the blood injection port of the cuvette device may be exposed to the outside of the housing device in a state where the cuvette device is gripped by the grip portion.

According to the cuvette apparatus and the biooptical measurement apparatus including the cuvette apparatus of the present invention, the diameter of the first transmission window of the first plate is smaller than the width of the second transmission window of the second plate and the width of the third opening of the chamber plate So that outgoing light having a large horizontal component in the light scattered by blood cells in the blood sample can be blocked. As a result, the deviation of the emission angle of the light emitted through the first transmission window and incident on the light reception element can be reduced, and the measurement deviation of the light reception element caused by the deviation of the incident angle of light can be reduced.

Since the light blocking coating film is formed on the surfaces of the first plate and the second plate, external light can be effectively blocked to prevent optical interference due to external light.

In addition, when the light blocking coating film is water repellent, the blood sample can be prevented from spreading to the lower surface of the first plate or the upper surface of the second plate, not the receiving space inside the cuvette apparatus.

FIG. 1A is a plan view for explaining a cuvette device according to an embodiment of the present invention, and FIG. 1B is a sectional view taken along a cutting line A-A 'shown in FIG. 1A.
FIG. 2A is a plan view of the first plate shown in FIGS. 1A and 1B, and FIG. 2B is a sectional view taken along a cutting line B-B 'shown in FIG. 2A.
FIGS. 3A and 3B are plan views for explaining the embodiments of the second plate shown in FIGS. 1A and 1B, and FIG. 3C is a sectional view taken along the cutting line C-C 'shown in FIG. 3A.
4 is a plan view of the chamber plate shown in Figs. 1A and 1B.
5 is a cross-sectional view illustrating a bio-optical measuring apparatus according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which exemplary embodiments of the invention are shown. It is to be understood, however, that the invention is not intended to be limited to the particular forms disclosed, but on the contrary, is intended to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Like reference numerals are used for like elements in describing each drawing. In the accompanying drawings, the dimensions of the structures are shown enlarged or reduced from the actual size for the sake of clarity of the present invention.

The terminology used in this application is used only to describe a specific embodiment and is not intended to limit the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In the present application, the terms "comprises", "having", or "having" are used to specify that there is a feature, a number, a step, an operation, an element or a combination thereof disclosed in the specification, It should be understood that the foregoing does not preclude the presence or addition of other features, numbers, steps, operations, elements, or combinations thereof.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as commonly used and predefined terms should be construed to have meanings consistent with their contextual meanings in the relevant art and are not to be construed as ideal or overly formal in meaning unless expressly defined in the present application .

FIG. 1A is a plan view for explaining a cuvette device according to an embodiment of the present invention, and FIG. 1B is a sectional view taken along a cutting line A-A 'shown in FIG. 1A. FIG. 2A is a plan view of the first plate shown in FIGS. 1A and 1B, and FIG. 2B is a sectional view taken along a cutting line B-B 'shown in FIG. 2A. FIGS. 3A and 3B are plan views for explaining the embodiments of the second plate shown in FIGS. 1A and 1B, and FIG. 3C is a sectional view taken along the cutting line C-C 'shown in FIG. 3A. 4 is a plan view of the chamber plate shown in Figs. 1A and 1B.

Referring to FIGS. 1A, 1B, 2A, 2B, 3A, 3B, 3C and 4, a cuvette device 100 according to an embodiment of the present invention includes a device for receiving a blood sample for optical inspection And includes a first plate 110, a second plate 120, and a chamber plate 130.

The first plate 110 may have a plate shape having a flat upper surface and a lower surface. The plane shape of the first plate 110 is not particularly limited, but for simplicity of explanation, the first plate 110 having a rectangular shape will be described as an example. That is, the first plate 110 includes a first edge 10a, a second edge 10b facing the first edge 10a, and a second edge 10b facing the first edge 10a. And a third edge 10c and a fourth edge 10d connecting the ends of the first and second edges 10a and 10b.

The first plate 110 is formed at a position spaced apart from the first edge 10a in the direction of the second edge 10b where the blood injection port 101 is located, A window 111 may be provided. The shape of the first transmission window 111 is not particularly limited. For example, the first transmission window 111 may have a circular shape having a first diameter.

In one embodiment, the first plate 110 may include a first transparent base plate 11 and a first light blocking coating layer 12 coated on a lower surface of the first base plate 11 .

The first base plate 11 may be formed of a transparent polymer material such as polyethylene terephthalate (PET), polyethylene (PE), or the like. The first light blocking coating layer 12 may be formed of a material having a hydrophobic property while blocking light, and the first light blocking coating layer 12 may be formed of a material capable of forming the first transmission window 111 The opening 12a may be formed. That is, the region of the first base plate 11 exposed by the opening 12a of the first light blocking coating layer 12 may form the first transmission window 111. [ For example, the first light blocking coating layer 12 may be formed using a composition containing a carbon-based material.

The second plate 120 may be disposed on the first plate 110, and may be in the form of a plate having a flat top surface and a bottom surface. The planar shape of the second plate 120 is not particularly limited. For example, the second plate 120 may have substantially the same planar shape as the first plate 110. For example, when the first plate 110 has a rectangular shape composed of the first to fourth edges 10a, 10b, 10c, and 10d, the second plate 120 may have the first to fourth And may have a rectangular shape composed of fifth to eighth corners 20a, 20b, 20c, and 20d corresponding to the corners 10a, 10b, 10c, and 10d, respectively.

The second plate 120 may include a second transmissive window 121 that overlaps the first transmissive window 111 of the first plate 110. The second transmission window 121 may have a larger area than the first transmission window 111 and the entire area of the first transmission window 111 may be exposed by the second transmission window 121 have. The shape of the second transmission window 121 is not particularly limited as long as it has a larger area than the first transmission window 111 and can expose the entire area of the first transmission window 111. 3A, the second transmissive window 121a may be configured to expose the entire area of the blood inlet 101 and the first transmissive window 111, as shown in FIG. 3A, 121a may be formed to extend from the fifth corner 20a toward the sixth corner 20b. 3B, the first transmissive window 111 is exposed by the second transmissive window 121b without exposing the blood injection port 101, so that the entire first transmissive window 111 is exposed, The second transmissive window 121b may extend from the fifth corner 20a at a position spaced apart from the fifth corner 20a in the direction of the sixth corner 20b.

In one embodiment, the second plate 120 may include a second transparent base plate 21 and a second light blocking coating 22 coated on the upper surface of the second base plate 21 .

The second base plate 21 may be formed of a transparent polymer material such as polyethylene terephthalate (PET), polyethylene (PE), or the like. In addition, the second light blocking coating layer 22 may be formed of a material having hydrophobicity while blocking light, and the second light blocking coating layer 22 may be formed of a material that forms the second transmission window 121 The opening 22a may be formed. That is, the area of the second base plate 21 exposed by the opening 22a of the second light blocking coating layer 22 may form the second transmission window 121. [ For example, the second light blocking coating layer 22 may be formed using a composition containing a carbon-based material.

The chamber plate 130 is disposed between the first plate 110 and the second plate 120 and includes a space in which a blood sample is injected and accommodated together with the first and second plates 110 and 120 .

The chamber plate 130 includes ninth to twelfth edges 30a and 30b corresponding to the fifth to eighth corners 20a, 20b, 20c and 20d of the second plate 120, respectively, 30c and 30d and is formed to be elongated in the direction from the ninth edge 30a to the tenth corner 30b in order to form a space into which the blood sample is injected, And an opening 131 exposing the entire region of the substrate 111.

The width W2 of the chamber plate opening 131 in the second direction X orthogonal to the first direction Y in which the blood is injected is greater than the width W2 of the chamber plate opening 131 in the first transmission window 111. [ And may be smaller than or equal to the width W1 of the second transmission window 121 in the second direction X. [ The width W2 of the chamber plate opening 131 in the second direction X may be greater than the width W2 of the chamber plate opening 131 in the second transmission window 121) in the second direction (X).

Meanwhile, the cuvette device 100 according to the embodiment of the present invention may further include a sensing electrode 140 formed on the upper surface of the first plate 110. 2A, when the blood sample is injected into the blood sample receiving space of the cuvette device 100, the sensing electrode 140 is disposed adjacent to the first transmission window 111, Can be detected.

According to the cuvette apparatus of the present invention, the diameter of the first transmission window of the first plate is formed to be smaller than the width of the second transmission window of the second plate and the width of the chamber plate opening, It is possible to block outgoing light having a large horizontal component in the scattered light. As a result, the deviation of the emission angle of the light emitted through the first transmission window and incident on the light reception element can be reduced, and the measurement deviation of the light reception element caused by the deviation of the incident angle of light can be reduced.

Since the light blocking coating film is formed on the surfaces of the first plate and the second plate, external light can be effectively blocked to prevent optical interference due to external light. In addition, when the light blocking coating film is hydrophobic, the blood sample can be prevented from spreading to the lower surface of the first plate or the upper surface of the second plate, not the receiving space inside the cuvette device.

5 is a cross-sectional view illustrating a bio-optical measuring apparatus according to an embodiment of the present invention.

5, a bio-optical measuring apparatus 1000 according to an embodiment of the present invention includes a cuvette device 1100, a housing device 1200, a light emitting device 1300, and a light receiving device 1400.

Since the cuvette device 1100 is substantially the same as the cuvette device 100 described with reference to Figs. 1 to 4, detailed description thereof will be omitted.

The housing device 1200 includes a body portion 1210 forming an insertion space into which the cuvette device 1100 is inserted and a grip portion 1220 disposed in the insertion space and gripping a part of the cuvette device 1100, . ≪ / RTI >

The light emitting device 1300 and the light receiving device 1400 may be coupled to the body 1210 such that the light emitting device 1300 and the light receiving device 1400 face each other with the cuvette device 1100 interposed therebetween.

The light emitting device 1300 may be disposed above the second transmission window of the second plate and may irradiate light to the blood sample stored in the cuvette device through the second transmission window. If the blood sample can be irradiated with light of a specific wavelength, the light source of the light emitting device 1300 is not particularly limited. For example, the light emitting device 1300 may include a light source such as an LED or a laser that emits infrared or visible light. In one embodiment, when the sensing electrode (see Fig. 2A) of the cuvette device 1100 senses a blood sample injected therein, the light emitting device 1300 may be configured to detect a blood sample contained in the cuvette device 1100, The sample can be irradiated with light.

The light receiving element 1400 receives light emitted through the first transmission window of the first plate among the light emitted by the light emitting element 1300, and can generate an electrical signal corresponding to the received light amount. For example, the light receiving element 1400 may include a photodiode.

The blood injection port of the cuvette device 1100 may be exposed to the outside of the housing device 1200 in a state where the cuvette device 1100 is gripped by the grip part 1220 of the housing device 1200. [ .

In this case, before the blood sample is injected in the same state that the cuvette device 1100 is grasped by the grip part 1220 of the housing device 1200, the preliminary optical inspection for grasping the optical effect by the cuvette device itself The blood sample can be injected to perform the optical inspection for grasping the optical effect of the cuvette device and the blood sample. As a result, the result of the optical inspection The correct optical inspection result can be calculated.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention as defined by the following claims. It can be understood that it is possible.

100, 1100: Cuvette device 101: Blood inlet
110: first plate 111: first transmission window
120: second plate 121: second transmission window
130: chamber plate 131: opening
1000: Optical measuring device 1200: Housing device
1300: light emitting element 1400: light receiving element

Claims (12)

A cuvette apparatus having a blood injection port into which a blood sample is injected and having an internal space for accommodating the injected blood sample,
A first plate having a first transmission window through which light is transmitted;
A second plate disposed above the first plate, the second plate having a larger area than the first transmission window and exposing the entire first transmission window; And
And a second plate that is disposed between the first plate and the second plate and extends from a first corner where the blood injection port is located to a first direction toward a second corner opposite to the first edge, And a chamber plate having a first opening to expose the region and form the interior space with the first and second plates,
The width of the second transmission window in the second direction perpendicular to the first direction in the upper portion of the first transmission window is larger than the width of the first opening in the second direction,
The first plate may include a first base plate formed of a transparent polymer material; And a second opening that is coated on a lower surface of the first base plate to block light and form the first transmission window, the first opening being formed of a material having hydrophobicity higher than that of the first base plate, And a first light blocking coating layer to prevent movement along the lower surface of the first plate. The method according to claim 1,
Wherein the width of the first opening in the second direction is greater than the width of the first transmissive window in the second direction.
delete 3. The method of claim 2,
And the second transmission window is formed to extend from the first edge of the second plate to expose the blood injection port. 3. The method of claim 2,
Wherein the second transmissive window is formed to extend from a position spaced apart from a first edge of the second plate in a second corner direction of the second plate opposite the first edge. delete The method according to claim 1,
Wherein the second plate includes a second base plate formed of a transparent polymer material and a second light blocking coating layer coated on an upper surface of the second base plate and blocking light,
And the second light blocking coating layer is formed with a third opening for forming the second transmission window. 8. The method of claim 7,
Wherein the second light blocking coating layer is formed of a hydrophobic material that is more hydrophobic than the second base plate to prevent the blood sample from moving along the upper surface of the second plate. The method according to claim 1,
Further comprising: a sensing electrode formed on an upper surface of the first plate, at least a portion of which is located in the inner space, and sensing a blood sample injected into the inner space. A second plate disposed on the first plate and having a larger area than the first transmission window and having a second transmission window exposing the entire first transmission window, A first plate disposed between the first plate and the second plate and extending from a first corner where a blood injection port into which a blood sample is injected is extended in a first direction toward a second corner opposing the first edge, 1. A cuvette apparatus comprising: a cuvette apparatus having a first opening to expose a whole region of a permeable window, the chamber plate forming an interior space in which the blood sample is received together with the first and second plates;
A housing unit including a body portion having an insertion space into which the cuvette device is inserted, and a grip portion disposed inside the insertion space and holding a part of the cuvette device; And
And a light emitting element and a light receiving element coupled to the body portion so as to be opposed to each other with the cuvette device interposed therebetween,
The width of the second transmission window in the second direction perpendicular to the first direction in the upper portion of the first transmission window is larger than the width of the first opening in the second direction,
The first plate may include a first base plate formed of a transparent polymer material; And a second opening that is coated on the lower surface of the first base plate to block light and form the first transmission window, the first opening being formed of a material having hydrophobicity higher than that of the first base plate, And a first light blocking coating layer for preventing movement along the lower surface of the first plate. 11. The method of claim 10,
And the width of the first opening in the second direction is larger than the width of the first transmission window in the second direction. 11. The method of claim 10,
Wherein the blood injection port of the cuvette device is exposed to the outside of the housing device in a state that the cuvette device is gripped by the grip portion.
KR1020170096013A 2017-07-28 2017-07-28 Cuvette device for optical measurement of blood sample and bio optical measurement device having the cuvette device KR101868346B1 (en)

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KR1020170096013A KR101868346B1 (en) 2017-07-28 2017-07-28 Cuvette device for optical measurement of blood sample and bio optical measurement device having the cuvette device

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KR1020170096013A KR101868346B1 (en) 2017-07-28 2017-07-28 Cuvette device for optical measurement of blood sample and bio optical measurement device having the cuvette device

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007303968A (en) * 2006-05-11 2007-11-22 Arkray Inc Method and apparatus for measuring concentration of specific component in blood sample
WO2012011262A1 (en) * 2010-07-22 2012-01-26 株式会社エンプラス Analysis tool and microanalysis system
KR20140063817A (en) * 2011-09-13 2014-05-27 올레코 리미티드 Diagnostic apparatus
KR20150011179A (en) * 2013-07-22 2015-01-30 삼성전자주식회사 Bio-sensor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007303968A (en) * 2006-05-11 2007-11-22 Arkray Inc Method and apparatus for measuring concentration of specific component in blood sample
WO2012011262A1 (en) * 2010-07-22 2012-01-26 株式会社エンプラス Analysis tool and microanalysis system
JP5902086B2 (en) * 2010-07-22 2016-04-13 株式会社エンプラス Analysis tool and micro analysis system
KR20140063817A (en) * 2011-09-13 2014-05-27 올레코 리미티드 Diagnostic apparatus
KR20150011179A (en) * 2013-07-22 2015-01-30 삼성전자주식회사 Bio-sensor

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