KR101850957B1

KR101850957B1 - Mesh for Medical Having Micro Needles and Manufacturing Method Thereof

Info

Publication number: KR101850957B1
Application number: KR1020150094830A
Authority: KR
Inventors: 류원형; 윤영남; 이지용
Original assignee: 연세대학교 산학협력단
Priority date: 2015-07-02
Filing date: 2015-07-02
Publication date: 2018-04-20
Also published as: KR20170004460A

Abstract

A medical mesh in which a micro needle is formed and a manufacturing method thereof are disclosed. A medical mesh (100) having a microneedle according to an embodiment of the present invention is a medical mesh (100) attached to an outer surface of a living tissue to perform a drug delivery function, and is made of a flexible and biocompatible material, A main body 110 of a mesh structure in which a plurality of mesh structures 111 are formed; And at least one micro needle 120 formed on one side surface of the main body 110 and coated on the outer surface with a drug to be delivered to a living body tissue.
According to the medical mesh of the present invention, it is possible to provide a medical mesh having a flexible structure in which microneedles can be easily fixed to lesion tissues to effectively transmit drugs, and according to the medical mesh manufacturing method of the present invention, By including a doctor blading step using a doctor blading method that enables programmable drug delivery by differently arranging differently coated or coated microneedles, a medical mesh capable of programmable drug delivery functions can be easily produced.

Description

TECHNICAL FIELD [0001] The present invention relates to a medical mesh having micro needles,

The present invention relates to a medical mesh having a microneedle and a method of manufacturing the same, and more particularly, to a medical mesh having a mesh structure formed of a flexible and biocompatible material having microneedles formed on one side thereof and a method of manufacturing the same.

Figure 1 shows a diagram illustrating bypass surgery using a vascular graft due to cardiac arteriosclerosis and peripheral arteriosclerosis.

As shown in FIG. 1, in patients with symptoms of coronary atherosclerosis or peripheral atherosclerosis, surgical bypass grafting using a vascular graft is preferred for treatment .

However, after bypass surgery, stenosis or occlusion of the graft occurs, and 30 to 50% of the patients who have undergone surgery die within five years. In addition, more than 50% of patients who underwent surgery require reoperation within 10 years or die. (M. S. Conte et al, Ann. Surg. 233 (2001) 445-452).

FIG. 2 shows a cross-sectional structure of a steady-state blood vessel and a vein graft showing stenosis due to abnormal cell proliferation of blood and inner membrane.

FIG. 2 shows that abnormal growth of smooth muscle cells in vascular tissue is an important factor causing stenosis and occlusion in transplanted blood vessels.

Therefore, there are many studies on drug therapy that can control abnormal growth of vascular smooth muscle. (1995) 7-18, J. L. Cox et al., Prog. Cardiovasc. Dis. 34 (1991) 45-68)

However, according to FDA's large-scale clinical trials, the effects of drug treatment have been found to be insignificant. As a result, it has been pointed out that the delivered drug failed to reach the smooth muscle cells of the tunica media and failed to maintain constant drug delivery.

To overcome this, a drug eluting stent (G. Acharya et al, Adv. Drug Delivery Rev 58 (2006) 387-401, B. Doyle et al, Med Devices: Evidence and Research 2 Various drug delivery systems have been developed, such as a drug delivery system of -55, a gel-type drug delivery system (US Patent 2005024905A1), and a cuff-type drug delivery system (US Patent 006726923B2).

However, in the above-mentioned various drug delivery systems, it is not easy to install the device inside the blood vessel when applying the drug delivery method through the inside of the blood vessel.

In addition, conventional gel-type or cuff-type devices having external vessel walls are easy to mount, but have uncertainties in the process of drug exiting the device reaching the target interstitium through the external wall of the vessel.

In addition, the existing outer wall-mounted devices have the possibility of imposing a burden on a vessel that repeats regular expansion and contraction.

Therefore, there is a need for a technique capable of solving the problems of the drug delivery system according to the above-mentioned prior art.

Korean Patent Publication No. 10-2010-0022237 (published on Mar. 02, 2010)

It is an object of the present invention to provide a flexible, micro-needle-shaped micro needle which can be easily fixed to a lesion tissue by having a flexible structure, effectively delivering a drug, and capable of delivering a programmable drug by differently arranging micro- A medical mesh of one structure is provided.

To achieve these and other advantages and in accordance with the purpose of the present invention, as embodied and broadly described herein, a medical mesh according to one aspect of the present invention is a medical mesh attached to an outer surface of a living tissue to perform a drug delivery function, comprising: a flexible, biocompatible material; A main body portion of the mesh structure; And one or more micro-needles formed on one side of the main body and coated with a drug to be delivered to a living tissue on an outer surface thereof.

The microneedles are composed of polytetrafluoroethylenes (Teflon®), polyethylenes, especially high density polyethylenes (HDPE), polypropylenes, polyurethanes, nylon series including nylons 6 and 12, polyesters including polyalkylene terephthalates, thermoplastic polyester elastomers, hard polybutylene terephthalates and soft amorphous segments are polyamides containing polyether glycols as backbone, polyimides, polyamides including polyether-block-copolyamide polymers (Pebax 계), and polyethylene terephthalate Or two or more.

The material constituting the microneedles may be a UV curable resin or an EB curable resin which is crosslinked or cured by receiving ultraviolet (UV), electron beam (EB), or light energy.

The biodegradable polymeric material may be a biodegradable polymer such as L-lactic acid, polycaprolactone, poly (lactide-co-glycolide), poly (hydroxybutyrate), poly hydroxybutyrate-co-valerate, polydioxanone, polyorthoester, polyanhydride, poly (glycotic acid), polylysine (D, L-lactic acid), poly (glycotic acid co-trimethylene carbonate), polyphosphoester, polyphosphoester urethane, It is composed of cyanoacrylates, poly (trimethylene carbonate), poly (iminocarbonate), copoly (ether-ester) (eg PEO / PLA), polyalkylene oxalates, polyphosphazenes and fibrin, fibrinogen, cellulose, starch, collagen, hyaluronic acid and biopolymers May be selected from one or more than one.

In addition, the micro needle can include a drug to be transferred into a living tissue.

The method of manufacturing a medical mesh according to one aspect of the present invention is characterized in that a) a method of manufacturing a medical mesh, comprising the steps of: a) forming a concave structure pattern of a structure corresponding to a shape of a micro needle on a mold surface; Forming mold; b) a doctor blading step of applying the polymer material constituting the microneedle onto the surface of the mold, filling the polymer material in the intaglio structure using a blade-shaped member and removing the residue; c) contacting the main body portion of the mesh structure in which a plurality of through holes are formed on one side of the mold filled with the polymer material; d) a main body pressing step for pressing the upper surface of the main body to attach the polymer material filled in the depressed structure of the mold to the main body; And e) a medical mesh completion step of removing the body portion from the mold to complete the medical mesh having the microneedles formed thereon.

In the doctor blading step, the polymer material is selected from the group consisting of polytetrafluoroethylenes (Teflon®), polyethylenes, especially high density polyethylenes (HDPE), polypropylenes, polyurethanes, nylon series including nylons 6 and 12, polyesters including polyalkylene terephthalates, Thermoplastic polyester elastomers such as ㄾ, hard polybutylene terephthalates and soft amorphous segments are composed of polyamides, poly (ethylene terephthalate), including polyimides, polyether-block-copolyamide polymers (Pebax ㄾ) One or more selected from the group.

The biodegradable polymeric material may be a biodegradable polymer such as L-lactic acid, polycaprolactone, poly (lactide-co-glycolide) poly (hydroxybutyrate), poly (hydroxybutyrate-co-valerate), polydioxanone, polyorthoester, polyanhydride, poly (glycotic acid), poily (D, L-lactic acid), poly (glycotic acid co-trimethylene carbonate), polyphosphoester, , poly (amino acids), cyanoacrylates, poly (trimethylene carbonate), poly (iminocarbonate), copoly (ether-ester) (eg PEO / PLA), polyalkylene oxalates, polyphosphazenes and fibrin, fibrinogen, cellulose, starch, collagen, hyaluronic acid , And a biological polymer.

According to an embodiment of the present invention, the doctor blading step may include: b-1) preparing a drug to be used for each part of the living tissue to which the medical mesh is applied, and preparing the drug; And b-2) a doctor blading step of filling a macromolecular material containing a drug necessary for each part of the biotissue in the intaglio structure of the mold formed at a position corresponding to each part of the biotissue .

In one embodiment of the present invention, the method for fabricating a medical mesh may further include: f) a drug coating step of coating a drug to be transferred into a living tissue to at least a part of the microneedles formed on one side of the body part .

In this case, the f) drug coating step may include: f-1) preparing a drug to be used for each part of a living tissue to be applied with the medical mesh; And (f-2) a drug coating step of coating the surface of the microneedle formed at a position corresponding to each part of the living tissue with a drug necessary for each part of the living tissue.

According to another aspect of the present invention, there is provided a method of manufacturing a medical mesh, comprising the steps of: a) forming a concave structure pattern of a structure corresponding to a shape of a microneedle on a mold surface; b) a doctor blading step of applying the polymer material constituting the microneedle onto the surface of the mold, filling the polymer material in the intaglio structure using a blade-shaped member and removing the residue; c) applying an adhesive to the upper surface of the polymeric material; d) contacting the main body portion of the mesh structure in which a plurality of through holes are formed on one side of the mold filled with the polymer material; e) a main body pressing step for pressing the upper surface of the main body to attach the polymer material filled in the depressed structure of the mold to the main body; f) an upper surface light energy irradiation step of curing the polymer material and the adhesive by irradiating the upper surface of the mold filled with the polymer material with ultraviolet (UV), electron beam (EB), or light energy; And g) a medical mesh completion step of removing the body portion from the mold to complete the medical mesh having the microneedles formed thereon.

In one embodiment of the present invention, the main body pressing step includes: e-1) irradiating ultraviolet (UV), electron beam (EB), or light energy to the lower surface of the mold filled with the polymer material, And a lower surface light energy irradiation step of hardening the material.

In one embodiment of the present invention, in the doctor blading step, the polymer material is selected from the group consisting of polytetrafluoroethylenes (Teflon®), polyethylenes, especially high density polyethylenes (HDPE), polypropylenes, polyurethanes, nylon series including poly polyesters including terephthalates, thermoplastic polyester elastomers such as Hytrel,, polyamides including polyimides, polyether-block-copolyamide polymers (Pebax ㄾ), hard polybutylene terephthalates and soft amorphous segments, Polyethylene terephthalate (PET), or one or more selected from the group consisting of polyethylene terephthalate (PET).

In one embodiment of the present invention, the polymer material may be a UV curable resin or an EB curable resin which is crosslinked or cured by receiving ultraviolet (UV), electron beam (EB) have.

In this case, the curable resin may further include an oligomer, a monomer, or a photopolymerization initiator.

In one embodiment of the present invention, the method for fabricating a medical mesh may further include: h) a drug coating step of coating a drug to be transferred into the living tissue to at least a part of the microneedles formed on one side of the body part .

In this case, the h) drug coating step may include: h-1) preparing a drug to be used for each part of a living tissue to which the medical mesh is applied; And (h-2) a drug coating step of coating the surface of the microneedle formed at a position corresponding to each part of the living tissue with a drug necessary for each part of the living tissue.

In one embodiment of the present invention, the step of fabricating the mold comprises the steps of: (a-1) fabricating a master mold having a microneedle shape patterned by chemical etching, precision machining or electrical discharge machining A master mold manufacturing step; And a-2) a molding step of molding the polymer material having elasticity of a predetermined size together with the master mold.

In this case, the molding method of the a-2) mold molding step is a method of manufacturing a mold in which the micro needle shape pattern of the master mold is transferred using an elastic polymer mold method or an electroplating method .

The mold may be made of one or more materials selected from the group consisting of poly-dimethylsiloxane (PDMS), poly-caprolactone (PCL), PET, PU, PE, polyester and polyamide.

INDUSTRIAL APPLICABILITY As described above, according to the medical mesh of the present invention, it is possible to provide a medical mesh having a flexible structure in which microneedles can be easily fixed to lesion tissues and can effectively transmit drugs.

In addition, according to the medical mesh of the present invention, a medical mesh capable of programmable drug delivery can be provided by being manufactured by the doctor blading method so as to enable programmable drug delivery by differently arranging microneedles containing different or coated drugs can do.

In addition, according to the method for manufacturing a medical mesh of the present invention, a medical mesh having microneedles can be easily manufactured using a mold in which a concave structure pattern having a structure corresponding to the shape of the microneedles is formed.

In addition, according to the method of manufacturing a medical mesh of the present invention, by including a doctor blading step using a doctor blading method that enables programmable drug delivery by differently arranging microneedles containing different or coated drugs, It is possible to easily manufacture a medical mesh having a transfer function.

FIG. 1 is a view showing a bypass surgery using a blood vessel graft due to atherosclerosis and peripheral arteriosclerosis.
FIG. 2 is a view showing a cross-sectional structure of a steady-state blood vessel and a vein graft in which stenosis due to abnormal cell proliferation of blood and inner membrane has occurred.
FIG. 3 is a conceptual diagram showing a drug delivery principle of a microneedle-formed mesh for treating cardiovascular diseases capable of programmable drug delivery.
4 is a plan view showing a main body of a medical mesh according to an embodiment of the present invention.
5 is a photograph showing a medical mesh according to an embodiment of the present invention.
6 is a flowchart illustrating a method of manufacturing a medical mesh according to an embodiment of the present invention.
FIG. 7 is a flowchart showing the doctor blading step in the medical mesh production method shown in FIG. 6 in more detail.
FIG. 8 is a flow chart showing the drug coating step in more detail in the method of manufacturing a medical mesh shown in FIG.
FIGS. 9 and 10 are side schematic views showing a process of manufacturing a medical mesh by the medical mesh manufacturing method shown in FIG.
11 is a flowchart illustrating a method of manufacturing a medical mesh according to an embodiment of the present invention.
FIG. 12 is a flowchart showing the doctor blading step in more detail in the medical mesh production method shown in FIG.
Fig. 13 is a flowchart showing the drug coating step in more detail in the method of manufacturing the medical mesh shown in Fig.
14 and 15 are side schematic views showing a process of manufacturing a medical mesh by the medical mesh manufacturing method shown in FIG.
16 is a perspective view showing a medical mesh according to an embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. Prior to the description, terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary meanings and should be construed in accordance with the technical concept of the present invention.

Throughout this specification, when a member is "on " another member, it includes the case where there is another member between the two members as well as when the member is in contact with the other member.

Throughout this specification, when an element is referred to as "including" an element, it is understood that it may include other elements as well, without departing from the other elements unless specifically stated otherwise.

FIG. 3 is a conceptual diagram showing a drug delivery principle of a mesh in which a micro needle for therapeutic cardiovascular disease capable of delivering a programmable drug is formed.

In the microneedles formed in the mesh shown in Fig. 3, a drug acting over 1 to 2 weeks and a drug acting over 3 to 4 weeks are applied. Different drugs with slow release properties can be coated or applied on the surface of the micro needle to achieve programmable drug therapy.

Referring to FIG. 3, the present invention increases drug delivery efficiency to vascular tissue using a micro needle structure, and has a flexible and flexible structure.

This device is capable of attaching microneedles that do not burden the vessels that repeatedly inflate and deflate regularly, and it has the advantage of being able to insert the microneedles in close contact with complex Y-shaped joints, I have.

4 is a plan view showing a main body of a medical mesh according to an embodiment of the present invention.

Referring to FIG. 4, the medical mesh 100 according to the present embodiment uses a biocompatible mesh substrate to provide a medical mesh 100 having flexible, folded and unfolded micro-needles.

For biocompatible polymer substrates, biodegradable polymers or biomaterial polymers may be used.

Examples of biodegradable polymers include biodegradable polymers such as L-lactic acid, polycaprolactone, poly (lactide-co-glycolide), poly (hydroxybutyrate), poly (hydroxybutyrate-co-valerate), polydioxanone, , polyanhydride, poly (glycotic acid), poily (D, L-lactic acid), poly (glycotic acid co-trimethylene carbonate), polyphosphoester, polyphosphoester urethane, poly (amino acids), cyanoacrylates, iminocarbonate, copoly (ether-ester) (eg PEO / PLA), polyalkylene oxalates, polyphosphazenes and fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid. As a representative example of the polymer for biomaterial, silk fibroin excellent in biocompatibility with blood vessel tissue can be mentioned. A micro needle is manufactured by micro molding on the surface of the polymer substrate.

5 is a photograph showing a medical mesh according to an embodiment of the present invention.

5, the medical mesh 100 according to the present embodiment is a medical mesh 100 attached to an outer surface of a living tissue and performing a drug delivery function. The mesh 100 includes a main body portion 110 and a main body portion 100 And a microneedle 120 formed on one side of the microneedle 120. [

The microneedles 120 according to the present embodiment are not particularly limited as long as they are made of a polymer material harmless to the body tissues. For example, polytetrafluoroethylenes, polyethylenes, high density polyethylenes (HDPE), polypropylenes, polyurethanes, nylon 6, nylon 12, nylon series, polyalkylene terephthalate, polyesters, thermoplastic polyester elastomers, polyamides including polyether glycols, poly amides, and polyether-block-copolyamide polymers including hard polybutylene terephthalates and soft amorphous segments , Polyethylene terephthalate (PET), or the like. More specifically, a representative example of polytetrafluoroethylenes is Teflon®, a representative example of thermoplastic polyester elastomers is Hytrel®, and a typical example of polyether-block-copolyamide polymers is Pebax®.

The polymer material constituting the microneedles 120 may be a UV curable resin that is crosslinked or cured by receiving light energy including ultraviolet rays (UV, ultraviolet), electron beams (EB, electron beam) And a curable resin.

According to the medical mesh of the present invention, it is possible to provide a medical mesh having a flexible structure in which microneedles can be easily fixed to lesion tissues and can effectively deliver drugs. In addition, according to the medical mesh of the present invention, a medical mesh capable of programmable drug delivery can be provided by being manufactured by the doctor blading method so as to enable programmable drug delivery by differently arranging microneedles containing different or coated drugs can do.

A method of forming the micro needle 120 on the surface of the main body 110 will be described below.

FIG. 6 is a flowchart illustrating a method of manufacturing a medical mesh according to an embodiment of the present invention. FIG. 7 is a flowchart showing the doctor blading step of the medical mesh manufacturing method shown in FIG. 6 in more detail. FIG. 8 shows the drug coating step in detail in the medical mesh manufacturing method shown in FIG. Is shown. 9 and 10 are side schematic views showing the process of manufacturing the medical mesh by the medical mesh manufacturing method shown in FIG.

Referring to FIG. 6, the medical mesh manufacturing method (S100) according to the present embodiment includes a mold making step S110, a doctor blading step S120, a body part contacting step S130, a body part pressing step S140 And a medical mesh completion step S150.

6 and the side view schematically shown in FIGS. 9 and 10, the mold making step S110 is a step of forming the mold 20 on the surface of the mold 20 corresponding to the shape of the micro needle 120 Thereby forming the engraved structure 21 pattern.

The mold making step S110 may be a configuration including a master mold making step S111 and a mold molding step S112.

At this time, the master mold manufacturing step S111 is a step of manufacturing a master mold in which the microneedle shape is patterned by chemical etching, precision machining or electrical discharge machining. The mold molding step S112 is a step of molding a polymer material having elasticity of a predetermined size together with the master mold.

More specifically, the molding method of the mold molding step S112 is to manufacture the mold 20 transferred with the microneedle pattern of the master mold by using an elastic polymer mold method or an electroplating method Lt; / RTI >

The mold 20 may be made of one or more materials selected from the group consisting of poly-dimethylsiloxane (PDMS), poly-caprolactone (PCL), PET, PU, PE, polyester and polyamide.

The doctor blading step S120 is a step of applying the polymer material 30 constituting the microneedle 120 onto the surface of the mold 20 and then applying the blade material 40 to the engraved structure 21 Filling the polymer material 30 and removing the residue.

The polymer material 30 applied on the surface of the mold 20 may include polytetrafluoroethylenes (Teflon ㄾ), polyethylenes, particularly high density polyethylenes (HDPE), polypropylenes, polyurethanes, nylon series including nylon 6 and 12, and polyalkylene terephthalate thermoplastic polyester elastomers such as polyesters, Hytrel,, hard polybutylene terephthalates and soft amorphous segments, polyamides including polyether-block-copolyamide polymers (Pebax ㄾ), polyethylene terephthalate), and the like. Further, the polymer material 30 may be composed of a biodegradable polymer material, and specific examples thereof are mentioned above.

More specifically, the doctor blading step S120 may be a configuration including the drug preparation step S121 and the doctor blading step S122. The drug preparing step S121 is a step of selecting and preparing a drug necessary for each part of a living tissue to which the medical mesh 100 is applied. In the doctor blading step S122, a polymer material 30 containing a drug necessary for each part of the living tissue is placed in the intaglio structure 21 of the mold 20 formed at a position corresponding to each part of the living tissue Filling step.

As shown in FIG. 16, a positional coordinate corresponding to each part of the living tissue is determined, and then a polymer material including a drug is filled in the depressed structure of the mold at the corresponding position.

Also, unlike the above-mentioned method, a method using a mask can be used. When performing the doctor blading process after masking the remaining intaglio structure while leaving only the intaglio structure to be filled with the first drug, the first drug can be filled in the intaglio structure at a specific position. A doctor blading process is performed after masking the remaining intaglio structure leaving only the intaglio structure to be filled with the second drug to fill the intaglio structure at another position with the first drug and the second drug having different sustained release properties . Repeated use of the above-mentioned method makes it possible to reliably and easily fill other drugs with a slow release to a specific position.

As a result, as shown in FIG. 16, the micro needle can be manufactured by different kinds of drugs according to each column or row. In some cases, different types of drugs may be applied for each coordinate. The medical mesh 100 thus fabricated has a flexible structure and can exhibit a programmable drug delivery function.

9, the main body contacting step S130 includes a step of forming a plurality of through holes 111 on one side of the mold 20 filled with the polymer material 30, (110).

The main body pressing step S140 is a step of pressing the upper surface of the main body 110 to attach the polymer material 30 filled in the depressed structure 21 of the mold 20 to the main body 110. [

The medical mesh completion step S150 is a step of removing the main body 110 from the mold 20 to complete the medical mesh 100 in which the microneedles 120 are formed.

The medical mesh manufacturing method (S100) according to the present embodiment further includes a drug coating step (S160) of coating a drug to be transferred into the living tissue on at least a part of the micro needle 120 formed on one side of the main body 110 May be included.

More specifically, the drug coating step S160 includes a drug preparing step S161 for selecting and preparing a drug necessary for each part of a living tissue to which the medical mesh 100 is applied, And a drug coating step (S162) of coating the surface of the needle 120 with a drug necessary for each part of the living tissue, respectively.

11 is a flowchart illustrating a method of manufacturing a medical mesh according to an embodiment of the present invention. 12 is a flowchart showing the doctor blading step of the medical mesh manufacturing method shown in FIG. 11 in more detail. FIG. 13 shows the drug coating step of the medical mesh manufacturing method shown in FIG. 11 in more detail Is shown. 14 and 15 are side schematic views showing the process of manufacturing the medical mesh by the medical mesh manufacturing method shown in FIG.

11, a medical mesh manufacturing method (S200) according to the present embodiment includes a mold making step S210, a doctor blading step S220, an adhesive applying step S230, a main body contacting step S240, A main body pressing step S250, a top surface light energy irradiation step S260, and a medical mesh completion step S270.

14 and 15, the mold fabricating step S210 is a step of fabricating a mold 20 having a structure corresponding to the shape of the micro needle 120 on the surface of the mold 20 Thereby forming the engraved structure 21 pattern. The detailed description thereof will be omitted because it is the same as the above-described mold making step (S110).

In the doctor blading step S220, the polymer material 30 constituting the microneedles 120 is coated on the mold surface, and then the polymer blend is applied to the polymer material 30 in the intaglio structure 21 using the blade- The step of filling the material 30 and removing the residue is the same as the doctor blading step (S120) described above.

As a next step, the adhesive applying step S230 is a step of applying the adhesive 50 to the upper surface of the polymer material. Specifically, an adhesive layer is formed on the upper surface of the cured polymer material by using a screen printing technique. At this time, the adhesive used is not particularly limited as long as it is an adhesive harmless to the human body, and may preferably be a light-curable polymer material such as a polymer material constituting the micro needle.

As shown in FIG. 15, the main body contacting step S240 includes a main body portion of a mesh structure having a plurality of through holes 111 formed on one side of the mold 20 filled with the polymer material 30 110).

The main body pressing step 250 is a step of pressing the upper surface of the main body 110 to attach the polymer material 30 filled in the depressed structure 21 of the mold 20 to the main body 110. The lower surface of the mold 20 filled with the polymer material 30 is irradiated with ultraviolet (UV) light, electron beam (EB) or light energy to cure the polymer material 30, And the irradiation step S251 may be performed simultaneously.

As a next step, the upper surface light energy irradiation step S260 irradiates the upper surface of the mold 20 filled with the polymer material 30 with ultraviolet (UV), electron beam (EB) Thereby curing the polymer material and the adhesive.

The polymer material 30 may include a UV curable resin, an EB curable resin, and a thermosetting resin which are crosslinked or cured by receiving light energy including ultraviolet (UV), electron beam (EB) have. In this case, the above-mentioned curable resin may further include an oligomer, a monomer, or a photopolymerization initiator.

The medical mesh completion step S270 is a step of removing the main body 110 from the mold 20 to complete the medical mesh 100 in which the micro needle 120 is formed.

In addition, the medical mesh manufacturing method (S200) according to the present embodiment may further include a drug coating step (S280). The detailed description thereof will be omitted because it is the same as the above-mentioned drug coating step (S160).

According to the method for manufacturing a medical mesh of the present invention, a medical mesh having microneedles can be easily fabricated using a mold having a relief structure pattern corresponding to the shape of the microneedles. In addition, according to the method of manufacturing a medical mesh of the present invention, by including a doctor blading step using a doctor blading method that enables programmable drug delivery by differently arranging microneedles containing different or coated drugs, It is possible to easily manufacture a medical mesh having a transfer function.

In the foregoing detailed description of the present invention, only specific embodiments thereof have been described. It is to be understood, however, that the invention is not to be limited to the specific forms thereof, which are to be considered as being limited to the specific embodiments, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims. .

That is, the present invention is not limited to the above-described specific embodiment and description, and various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims. And such variations are within the scope of protection of the present invention.

20: Mold
21: Negative structure
30: Polymer material
40: blade member
50: Adhesive
60: Drugs
100: Medical mesh
110:
111: Through hole
120: Micro needle
S100: How to make medical mesh
S110: Mold making step
S120: Doctor blading step
S121: drug preparation step
S122: Doctor blading step
S130: contact portion of main body portion
S140: Pressing step of the main body part
S150: Step for completing the medical mesh
S160: drug coating step
S161: drug preparation step
S162: drug coating step
S200: Method for making medical mesh
S210: Mold making step
S220: Doctor blading step
S221: drug preparation step
S222: Doctor blading step
S230: Adhesive application step
Step S240:
S250: Pressing step of the main body part
S251: Lower surface light energy irradiation step
S260: Top surface light energy irradiation step
S270: medical mesh completion step
S280: drug coating step
S281: Drug preparation step
S282: drug coating step

Claims

delete

As a method of manufacturing a medical mesh (S200)
a) forming a mold (S210) on the surface of the mold (20) to form an engraved structure (21) pattern having a structure corresponding to the shape of the micro needle (120);
b) After the mask is placed on the mold surface, the polymer material 30 constituting the microneedles 120 is applied on the mold surface and then the polymer material 30 A doctor blading step (S220) for selectively filling up the residue and removing the residue;
c) an adhesive applying step (S230) of selectively applying an adhesive to the upper surface of the cured polymer material using a screen printing technique according to each row or row to form an adhesive layer;
d) contacting the main body portion 110 of the mesh structure having a plurality of through holes 111 formed on one side of the mold 20 filled with the polymer material 30;
e) a main body pressing step S250 for pressing the upper surface of the main body 110 to attach the polymer material 30 filled in the depressed structure 21 of the mold 20 to the main body 110;
g) a medical mesh completion step S270 of removing the main body 110 from the mold 20 to complete the medical mesh 100 in which the microneedles 120 are formed;
Lt; / RTI >
In the doctor blading step S220, the polymer material 30 is made of a biodegradable polymer material,
The doctor blading step (S220)
b-1) a drug preparing step S221 for selecting and preparing a drug necessary for each part of a living tissue to which the medical mesh 100 is applied; And
b-2) After determining the positional coordinates corresponding to the respective parts of the living tissue, the biodegradable polymer material containing the first drug is filled in the depressed structure of the mold corresponding to the biodegradable polymer material, And the second drug having different sustained release properties is filled in the intaglio structure at another position so that only the intaglio structure to be filled with the second drug is left and the remaining intaglio structure A doctor blading step (S222) for masking and performing doctor blading again;
Lt; / RTI >
Wherein the biodegradable polymer material is a material that is dissolved and dissolved in the human body after delivering the drug to the lesion tissue.

13. The method of claim 12,
The main body pressing step S250 includes:
e-1) Lower surface light for curing the polymer material 30 by irradiating ultraviolet (UV), electron beam (EB), or light energy to the lower surface of the mold 20 filled with the polymer material 30 Energy irradiation step S251;
Further comprising the steps of:

13. The method of claim 12,
In the doctor blading step S220, the polymer material 30 may be selected from the group consisting of polytetrafluoroethylenes, polyethylenes, especially high density polyethylenes (HDPE), polypropylenes, polyurethanes, nylon series including nylons 6 and 12, polyesters including polyalkylene terephthalates, polyester elastomers, hard polybutylene terephthalates and soft amorphous segments are selected from one or more of polyamides, poly (ethylene terephthalate), polyether-block copolyamide polymers including polyimides, polyether glycols, Wherein said method comprises the steps of:

13. The method of claim 12,
The biodegradable polymeric material may be selected from the group consisting of biodegradable polymers such as L-lactic acid, polycaprolactone, poly (lactide-co-glycolide), poly (hydroxybutyrate), poly (hydroxybutyrate-co- valerate), polydioxanone, polyorthoester, polyanhydride, poly poly (glycotic acid), poly (D, L-lactic acid), poly (glycotic acid co-trimethylene carbonate), polyphosphoester, polyphosphoester urethane, poly (amino acids), cyanoacrylates, poly (trimethylene carbonate) wherein at least one selected from the group consisting of ether-ester (eg PEO / PLA), polyalkylene oxalates, polyphosphazenes and fibrin, fibrinogen, cellulose, starch, collagen, hyaluronic acid and biopolymers Way.

13. The method of claim 12,
Wherein the polymer material (30) comprises a UV curable resin or an EB curable resin which is crosslinked or cured by receiving ultraviolet (UV), electron beam (EB) or light energy.

17. The method of claim 16,
Wherein the polymer material (30) further comprises an oligomer, a monomer, or a photopolymerization initiator.

delete

13. The method of claim 12,
The medical mesh manufacturing method (S200) comprises:
h) a drug coating step (S280) for coating a drug to be transferred into the living tissue to at least a part of the microneedles (120) formed on one side of the body part (110);
Further comprising the steps of:

20. The method of claim 19,
H) drug coating step S280 comprises:
h-1) a drug preparing step S281 for selecting and preparing a drug necessary for each part of a living tissue to which the medical mesh 100 is applied; And
h-2) a drug coating step (S282) of coating the surface of the micro needle 120 formed at a position corresponding to each part of the living tissue with a drug necessary for each part of the living tissue;
Wherein the method comprises the steps of:

13. The method of claim 12,
In the medical mesh manufacturing method,
f) irradiating the upper surface of the mold 20 filled with the polymer material 30 with ultraviolet (UV), electron beam (EB) or light energy to cure the polymer material and the adhesive, (S260). &Lt; / RTI >

A medical mesh produced by the medical mesh manufacturing method according to claim 12.