KR101849662B1 - Herbal composition for prevention and relief of alcoholic hangover containing extract of portulaca oleracea - Google Patents

Abstract

The present invention relates to a herb medicine composition for prevention and relief of hangover, and more specifically, to a herb medicine composition for prevention and relief of hangover containing a Portulaca oleracea extract as a main ingredient, and also containing a mixture of a Stevia rebaudiana leaf extract, a Hovenia dulcis extract, an Opuntia humifusa extract, a green tea leaf extract and a Glycyrrhiza uralensis root extract.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a herbal composition for preventing and relieving hangovers,

The present invention relates to a herbal composition for prevention and resolution of hangover, and more particularly, to a herbal composition for prevention and elimination of hangover, which comprises as an active ingredient a carnauba wax extract as a main component, a stevia leaf extract, a 枳 子 extract, a quinquinone extract, a green tea leaf extract and a licorice root extract To a herbal composition for prevention and resolution of hangover.

Alcohol, the main component of alcohol, is absorbed by various pathways from the mucous membrane of the mouth to the intestine, but is mainly absorbed in the stomach and small intestine. If the body absorbs excess alcohol, the central nervous system becomes paralyzed and appears to be excited. However, an appropriate amount of alcohol may induce sleeping and an anesthetic effect. Therefore, proper drinking can relieve stress from social activities, reduce tension, and in some cases, it helps to improve health.

Alcohol absorbed from the gastrointestinal tract after drinking is distributed throughout the body, including the brain and liver, through the bloodstream. In hepatocytes, alcohol is oxidized by alcohol dehydrogenase (ADH) to become acetaldehyde. The acetaldehyde is decomposed into acetic acid by acetaldehyde dehydrogenase (ALDH), and then the whole body muscle or fat And finally decomposed into carbon dioxide and water.

Alcohol is metabolized only a certain amount of time per hour regardless of the amount of alcohol or blood concentration. The inverse of the enzyme involved in the metabolism of alcohol is determined by the genetic and environmental factors of each individual. , Weight, nutritional status, and physical condition. Acetaldehyde, which is produced during the metabolism of alcohol, temporarily causes a hangover such as thirst, fatigue, amnesia, throbbing, headache, flushing, vomiting, gastrointestinal disorder and diarrhea.

In order to solve the hangover problem caused by drinking alcohol, there has been actively developed a herbal composition for hangover resolution which can minimize the influence of alcohol on the human body by reducing the toxicity of alcohol and alcohol metabolites or inhibiting the expression of toxicity come. However, the efficacy of preventing and resolving the hangover of conventional herbal compositions is still unsatisfactory. In particular, since factors involved in alcohol metabolism are different for each person, development of a new herbal composition suitable for the individual constitution is continuously required.

On the other hand, Purslane is an annual plant which grows frequently in mountainous fields and roadside pavilions around the country, and is used as medicines such as detoxification, angelica, tonsilitis and diuretic in legumes. have. For example, Korean Patent No. 10-0442683 (Jul. 22, 2004) discloses an anticancer and antimicrobial agent which is characterized in that the main ingredient is dried bean curd hot water, and the ingredients include licorice, ginger, jujube, (May 07, 2014), which is based on olive oil extract and moromicho, and has antimicrobial, anti-inflammatory, anti-cancer, anti-aging, anti-obesity (July 29, 2014), the main component is carnauba and rice bran, and it has improved the digestive power, improved skin, improved resistance, reduced weight gain and relieved constipation. Have been introduced.

In addition, in the case of hangover relief, in Registration No. 10-1524373 (May 22, 2015), 30 to 80 parts by weight of mugwort leaf extract, 10 to 50 parts by weight of pine needles extract, 5 to 20% by weight of a mixed medicinal extract comprising 5 to 20 parts by weight of glycyrrhiza extract, 5 to 20 parts by weight of a chrysanthemum extract, 5 to 20 parts by weight of an indigo extract and 5 to 20 parts by weight of a licorice extract; (b) 5 to 20% by weight of a sweetener and a seasoning; And (c) a purified water of the remaining amount.

Among them, the hangover-removing beverage composition contains the extract of Aspergillus oryzae, but the main ingredient is the extract of Aspergillus oryzae and the extract of Aspergillus oryzae is one of the six kinds of auxiliary materials, 1.29% by weight (0.42% by weight in the case of Example 1 and Example 6), so that the hangover effect of the ponytail is hardly utilized.

Registration No. 10-0442683 (July 22, 2004) Open Patent No. 10-2014-0052619 (May 07, 2014) Registration No. 10-1426501 (Jul. 29, 2014) Registration No. 10-1524373 (May 22, 2015)

As we have seen, legume has been used as a folk remedy in the past because of its physiologically diverse efficacy. Accordingly, the inventors of the present invention have focused on antioxidant efficacy in the effectiveness of Peppermint, and as a result, found that Peppermint Extract has an excellent effect on prevention and elimination of hangover, leading to the present invention.

Accordingly, it is an object of the present invention to provide a herbal composition for preventing and eliminating hangovers, which comprises a carnauba wax extract as a main component.

The herbal composition for preventing and eliminating hangover according to the present invention is characterized in that it contains chrysanthemum chrysanthemum extract as a main component and the extract includes Stevia leaf extract, Chrysanthemum chrysanthemum extract, Chenille seed extract, Green tea leaf extract and Licorice root extract do.

The herbal composition for preventing and eliminating hangover according to the present invention comprises 7 to 40 parts by weight of a Stevia leaf extract, 4 to 25 parts by weight of an extract of Stevia leaf, 7 to 25 parts by weight 1 to 10 parts by weight of green tea leaf extract, and 1 to 3 parts by weight of licorice root extract.

The herbal composition for prevention and elimination of hangovers according to the present invention can rapidly decompose the alcohol in the body by taking the alcohol before and after drinking, rapidly lowering the blood alcohol concentration and rapidly metabolizing the acetaldehyde generated in the alcohol metabolism, There is an effect of effectively preventing and eliminating the hangover phenomenon.

Hereinafter, the present invention will be described in detail. However, even if it is indispensable to carry out the present invention, the detailed description of the matters which belong to the known technology or which can be easily carried out by a person skilled in the art from the ordinary technology will be omitted.

In the present invention, Portulaca oleracea L., a herbal medicine used to produce the main component of the pepper shrimp extract of the present invention, is an annual plant called Hachian or Pig paste, and acts on the heart and colon, It is said that it has the efficacy of eliminating the eosinophilia and urine, and it is also used as an antidote for poisoning and poisoning in folk remedies.

According to the pharmacological experiments, the extracts of black pepper have been shown to have action to increase the blood pressure, to enhance the blood pressure, to inhibit the function of the uterus, to stop the blood, and to prevent colitis. The components of the pepper extract include L-noradrenaline, dopamine, dopa, and other vitamin K and a large amount of organic acid, glutamic acid, aspartic acid, aspartic acid, alanine, and the like. In addition, it is reported that the content of gamma linolenic acid and omega-3-unsaturated fatty acid, which are contained in fishes largely, are high in the outbreak of leggings, especially in leaves and stems.

According to a recent research report, flavon, which is the largest component of the carrot extract, has been reported to excel in antioxidative effects and is effective in preventing aging and heart disease by eliminating factors that cause stress. , And cosmetics.

Particularly, linolenic acid and omega-3-unsaturated fatty acids accelerate the formation of alcohol dehydrogenase, and the alcohol dehydrogenase oxidizes alcohol to acetaldehyde in the liver, and the acetaldehyde The process of decomposition into acetic acid through acetaldehyde dehydrogenase, which is present in liver cells, shows the efficacy of preventing hangover and further relieving hangover. In the present invention, the content of the glycyrrhiza oil extract is 100 parts by weight as a reference content.

Stevia (Stevia rebaudiana bertoni) is a plant of Asteraceae that grows in the high mountains of northeastern Paraguay. Especially stevia leaf contains a large amount of sweet substance such as stevioside and rebaudioside. Therefore, Stevia leaf extract is a sugar substitute sweetener that is widely used in various foods such as seafood, pickles, desserts, and confectionary. It helps modern people to prevent diabetes, obesity, hyperlipidemia and cavities (Toskulkao C et al. 1997) It is also used for medical purposes because of its therapeutic effect.

The stevia leaf extract is stable to heat and maintains its pH and sweet taste even after heating at 120 ° C for 1 hour. In the meantime, toxicity has been extensively studied. However, no toxicity was observed in mammals including carcinogenicity and genotoxicity (Koyama E et al. 2003).

In the present invention, the Stevia leaf extract has a function of improving convenience of taking by masking an unpleasant taste of the bitter taste, salty taste and other herbal ingredients, which appear in the pepper extract as a sweetener.

The content of the stevia leaf extract is 7 to 40 parts by weight based on 100 parts by weight of the carrot extract. If the content of the stevia leaf extract is less than 7 parts by weight, the undesirable taste of other herbal ingredients can not be masked sufficiently, . On the contrary, when the amount of the active ingredient is more than 40 parts by weight, the content of other herbal medicine ingredients such as the glycyrrhiza extract is lowered, and the effect of preventing and solving hangover is lowered.

The above-mentioned geonja (枳 子) is a fruit of a hinoki tree. Hovenia is a deciduous tree of Rhamnaceae. It is also called a "tree tree" and is distributed in Korea, Japan, and China. The fruit of the hinoki tree, that is, the globe, is brown with a diameter of about 8mm. It is shaped like a chicken's claw.

At the time of the ripening, the planet becomes thicker and thicker, and has a fragrant smell and a sweet taste. It plays a role of enhancing the taste of food. In addition, the Zygote extract has excellent efficacy in hangover relief, especially in the treatment of upper gastrointestinal, liver, and lung colon by alcohol, relieving heat and thirst in the chest, alleviating vomiting, diuretic, It is known to work. Ampelopsin and hovenitins, among the constituents of the endemic extract, protect the liver cells of the drinker.

The content of the mitochondria extract is 4 to 25 parts by weight based on 100 parts by weight of the extract. If the amount of the kidney extract is less than 4 parts by weight, the content of amperopine and hobenitintes is lowered to lower the protective function of the hepatocyte. On the other hand, if the content of the kidney extract is more than 25 parts by weight, the content of the alkaloid component called pyrrolizidine increases There is a risk of adversely affecting the liver.

Next, Opuntia humifusa is a plant belonging to the genus Cactus and is widely distributed in the Mediterranean and Central America, and its biochemical characteristics are well known. The stem of Cheonnyuncho contains a large amount of polyphenols and flavonoids compared to other cacti, and has antioxidant and scavenging activity against DPPH radical (diphenyl-1picryl hydrazyl).

In addition, it has been known that Chenilleae extract has a hypoglycemic and hypolipidemic activity and regulates inflammatory response-promoting cytokine expression in sereptozotocin-induced diabetic mice. In particular, vitamin C contains a large amount of flavonoids, vitamin C, amino acids, calcium, and dietary fiber. The vitamin C inhibits the production of acetaldehyde, which is a metabolite of alcohol, in the liver.

The content of the natural herbal extract is 7 to 25 parts by weight based on 100 parts by weight of the carrot extract. If the content of the natural herbal extract is less than 7 parts by weight, extraction of the active ingredient is difficult. On the other hand, if the content of the natural herbal extract is more than 25 parts by weight, it may cause discomfort to the user, The content of the perphene component and the like may increase, which may cause a somewhat rough taste.

Camellia sinensis is an evergreen broad-leaved shrub belonging to the Pinus densiflora after the tea plantation in China, and its name and quality vary according to the size and shape of the leaf and the time of collection. Tea leaves can be harvested more than three years after planting, and the extract of tea leaves is green tea (綠茶), which is known to have begun drinking from ancient China.

The main ingredients of green tea leaf extract are caffeine, tannin, theanine, siccenol, vitamin C, vitamin B1, B2, niacin, pentotenic acid, inositol, and rutin. And green tea leaf extract contains a tannin ingredient called catechin, which gives a bland taste. Catechin, a type of polyphenol, has antioxidant activity, and EGCG, which is the most potent component of catechin, is known to have antioxidant activity 20 times higher than vitamin C.

The green tea leaf extract has a function of lowering the blood alcohol concentration by the main component catechin, and the content thereof is 1 to 10 parts by weight based on 100 parts by weight of the carrot extract. If the content of the green tea leaf extract is less than 1 part by weight, the effect of protecting the stomach and the liver is insignificant. On the other hand, if the content is more than 10 parts by weight, the synergistic effect of increasing the amount of green tea leaves is not preferable.

Licorice (Glycyrrhiza uralensis Fisch) is a perennial plant of soybean (Fabaceae), which has a natural sweet taste and various pharmacological properties. In recent years, the efficacy and efficacy of licorice has been recognized, and it has been developed as a functional food or a herbal cosmetics, and the demand is increasing every year. Glycyrrhizin, one of the representative ingredients in licorice roots, is a natural sweetener. It is also used as an antioxidant, in addition to strong sweetening agents, which produce about 50 times the sweetness of sugar.

In Oriental medicine, the physiological activity of licorice root extract is known to have anti-inflammatory, detoxifying, anticancer and antioxidant effects, and melanin formation inhibitory action in oriental cosmetics. In addition, clinically, licorice root extract is a medicinal agent that alleviates pain and convulsions and circulates the tension of nerves, and is also widely used as a treatment for liver diseases and allergic diseases, as an antiulcer agent, and as a dry digestive agent.

In addition, the licorice root extract contains glycyrrhizin which exhibits a variety of detoxifying functions and functions to aid liver detoxification. The content of the glycyrrhizin is preferably 1 to 3 parts by weight per 100 parts by weight of the extract. If the content of the licorice root extract is less than 1 part by weight, there is a problem that it is difficult to extract the sweetness of the licorice and the active ingredient such as organic acid. On the other hand, if the content exceeds 3 parts by weight, there is a problem that the palatability of the plant is reduced.

In the present invention, the herbal medicine extracts are washed at a temperature of 92 to 98 ° C, preferably 95 ° C, after washing each of the herbal medicines, ie, black currant, stevia leaf, Extraction with hot water for 2 hours, extraction with a fermentation alcohol having an alcohol content of 30 to 95%, filtration to remove solid content, and concentration of the filtrate under reduced pressure in a conventional manner.

The herbal composition for prevention and elimination of hangover according to the present invention is characterized by containing only six herbal medicine extracts produced by this method, that is, carnauba wax extract, Stevia leaf extract, Zygoma extract, quinquinone extract, green tea leaf extract and licorice root extract In addition to these herbal medicine extracts, conventional additives may include sweeteners, acidifiers, vitamins and the like.

[Example] Preparation of herbal composition for prevention and elimination of hangover

Each of herbal medicine extracts and other additives were mixed with the components and the contents ratios as shown in Table 1 below to prepare the herbal composition for prevention and resolution of hangover of the present invention.

Constituent Content ratio (unit: wt%) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Sorghum extract 40 45 50 55 60 65 Stevia leaf extract 15 15 15 10 5 5 Zygote Extract 10 10 5 5 5 3 Millennium extract 10 5 5 5 5 5 Green tea leaf extract 4 4 4 4 4 One Licorice Root Extract One One One One One One Liquid fructose 11 11 11 11 11 11 Enzyme treatment Stevia 0.035 0.035 0.035 0.035 0.035 0.035 Acidulant 0.35 0.35 0.38 0.38 0.40 0.40 vitamin 0.045 0.045 0.045 0.045 0.045 0.045 Purified water Balance Balance Balance Balance Balance Balance Sum 100% 100% 100% 100% 100% 100%

In Table 1, the liquid fructose was 75 Brix and the swollen sugar content was 55% or more. Enzyme-treated stevia was used as a stevia-50 (enzyme-treated stevia 100) Respectively. In addition, 99% ~ 105% of pure acid was used as citric acid (crystal) of WEIFANG ENSIGN INDUSTRY in China, and vitamins used commercially available vitamins B1, B2, B6 and C were used.

[Test Example 1] Sensory evaluation

For the herbal composition of Examples 1 to 6, three experts were subjected to sensory evaluation of taste, aroma and color by a five-point scale method, respectively, and the results are shown in Tables 2 and 3 below. For reference, the evaluation criteria of the 5-point scale method is "5 points: very good" / "4 points: slightly better" / "3 points: normal" / "2 points: slightly worse" / "1 point: very bad" do.

Item Example 1 Example 2 Example 3 flavor 4 3 3 3 4 4 5 3 3 5 5 4 5 5 5 incense 5 4 2 4 3 3 5 5 2 3 5 5 4 5 4 color 3 4 2 2 4 5 4 3 2 4 5 4 4 5 4 Synthesis 4 3 2 3 3 4 4 3 2 4 5 4 4 5 4

Item Example 4 Example 5 Example 6 flavor 3 4 3 3 3 3 2 2 3 3 2 3 3 4 2 incense 5 3 3 5 2 4 4 5 3 5 2 One 2 2 2 color 3 5 4 3 2 3 2 3 2 2 2 2 One 3 One Synthesis 3 4 3 3 2 3 2 3 2 3 2 2 2 3 2

As shown in Tables 2 and 3, the herbal composition of Examples 1 to 6 showed the highest sensory evaluation for the herbal composition.

[Test Example 2] Performance measurement for prevention and elimination of hangover

As shown in the following Table 4, each of the 10 subjects was given a predetermined amount of alcohol, and 100 ml of the herbal composition of Example 3 was administered before and after drinking, and the change in blood alcohol concentration was measured over time The results are shown in Table 4 below.

Considering the difference of alcohol decomposition ability of each subject, different amount of alcohol was set for each individual, and the main product was the product name of Lotte Chilsung beverage Co., which had an alcohol content of 19%, and the amount of alcohol was 40ml Respectively. Alcoscan AL5500 from Sentec Korea Co., Ltd. was used as a drinking instrument.

Subject Blood alcohol concentration (unit:%) gender age weight Amount of alcohol Drinking before  30 minutes later  After 1 hour  After 2 hours south 35 70 5 glasses 0.0 0.06 0.02 0.01 south 26 58 3 glasses 0.0 0.02 0.01 0.00 south 42 68 8 glasses 0.0 0.09 0.06 0.04 south 55 62 10 glasses 0.0 0.10 0.08 0.05 south 45 64 9 glasses 0.0 0.08 0.05 0.03 female 26 50 3 glasses 0.0 0.06 0.04 0.01 female 32 48 5 glasses 0.0 0.08 0.03 0.05 female 30 51 4 glasses 0.0 0.04 0.03 0.00 female 53 56 5 glasses 0.0 0.07 0.05 0.05 female 42 52 3 glasses 0.0 0.03 0.01 0.00

On the other hand, after 3 days had elapsed from the day of the test of Table 4, the same amount of alcohol as that of Table 4 was administered to the subjects, but this time, the herbal composition of the present invention was not taken, Blood alcohol concentration was measured and the results are shown in Table 5 below.

Subject Blood alcohol concentration (unit:%) gender age weight Amount of alcohol Drinking before  30 minutes later  After 1 hour  After 2 hours south 35 70 5 glasses 0.0 0.05 0.04 0.03 south 26 58 3 glasses 0.0 0.03 0.02 0.01 south 42 68 8 glasses 0.0 0.10 0.09 0.07 south 55 62 10 glasses 0.0 0.11 0.09 0.07 south 45 64 9 glasses 0.0 0.07 0.06 0.04 female 26 50 3 glasses 0.0 0.05 0.04 0.03 female 32 48 5 glasses 0.0 0.09 0.07 0.05 female 30 51 4 glasses 0.0 0.05 0.03 0.02 female 53 56 5 glasses 0.0 0.08 0.06 0.05 female 42 52 3 glasses 0.0 0.02 0.01 0.00

As can be seen from the test results shown in Tables 4 and 5, when the herbal composition of Example 3 was administered before and after drinking, the blood alcohol concentration at the time of 30 minutes after drinking was lower than that of the control group The average blood alcohol level was decreased by about 25% when the herbal composition was consumed at 1 hour, and when the herbal composition was consumed at 2 hours after the herbal composition was consumed, an average of about 35% Decrease in blood alcohol concentration appeared.

Therefore, it has been confirmed that the herbal composition of the present invention has an effect of preventing and relieving hangover by rapidly metabolizing blood alcohol after drinking.

Claims (4)

delete delete 5% by weight of quercetin extract, 4% by weight of green tea leaf extract, 1% by weight of licorice root extract, 11% by weight of liquid fructooligosaccharide, 0.038% by weight of an enzyme-treated Stevia, 0.38% by weight of an acidulant, 0.045% by weight of a vitamin, and 8.54% by weight of purified water.
4. The method according to claim 3, wherein the Stevia leaf extract, Zygomycorrhizae extract, Chenille seed extract, green tea leaf extract and licorice root extract are extracted with hot water at 95 ° C for 2 hours, And the herbal composition for prevention and resolution of hangover.